Abstract: The present invention relates to a process for preparing 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepin (I) which comprises reacting 2,2?-dihydroxybiphenyl with PCl3 in the presence of a catalytic amount of an acid salt of a nitrogen base, wherein the reaction is carried out in the absence of external organic solvents.

Abstract: Bisphosphonamidate prodrugs of therapeutic bisphosphonate compounds and uses thereof to treat diseases are described.

Abstract: The invention relates to a method for producing 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepin (formula 1), comprising the following steps: a) addition of 2,2?-dihydroxybiphenyl, which is suspended in an inert solvant. into a reactor to an excess of phosphorous trichloride under inert gas and stirring; b) discharge and neutralization of the resulting gases from the reaction mixture; c) separation of the excess phosphorous trichloride and the solvant; d) obtention of 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepin.

Abstract: The present invention relates to a ligand and its use in a catalyst for the oligomerization of olefinic monomers, the ligand having the general formula (VI): (R9)(R10)P—N(R3)—P(R4)??(VI) wherein: the R9 and R10 groups are independently selected from optionally substituted alkyl or heteroalkyl groups; the R3 group is selected from hydrogen, a hydrocarbyl group, a substituted hydrocarbyl group, a heterohydrocarbyl group, a substituted heterohydrocarbyl group, a silyl group or derivative thereof; the R4 group is an optionally substituted alkylenedioxy or alkylenedimercapto structure which is bound to the phosphorus atom through the two oxygen or sulphur atoms of the alkylenedioxy or alkylenedimercapto structure or an optionally substituted arylenedioxy or arylenedimercapto structure which is bound to the phosphorus atom through the two oxygen or sulphur atoms of the arylenedioxy or arylenedimercapto structure.

Abstract: The invention relates to a method for producing 6-chlorodibenzo[d,f][1,3,2]-dioxaphosphepin (formula 1), comprising the following steps: a) addition of liquid 2,2?-dihydroxybiphenyl into a reactor to an excess of phosphorous trichloride under inert gas and stirring; b) discharge and neutralization of the resulting gases from the reaction mixture; c) separation of the excess phosphorous trichloride; d) obtention of 6-chlorodibenzo[d,f][1,3,2]-dioxaphosphepin.

Abstract: The present invention relates to a process for preparing 6-chlorodibenzo[d,f][1,3,2]dioxaphosphepin (I) which comprises reacting 2,2?-dihydroxybiphenyl with PCl3 in the presence of a catalytic amount of an acid salt of a nitrogen base, wherein the reaction is carried out in the absence of external organic solvents.

Abstract: Strecker reagents, their derivatives and methods for forming the same and improved Strecker reaction are provided. The electrophiles for asymmetric Strecker reaction include achiral N-phosphorazides, N-phosphoramides, N-phosphonyl imines and their derivatives. The nucleophiles for asymmetric Strecker reaction include chiral BINOL-derived azides, amides, imines and their derivatives, the chiral and achiral diol-based cyanides and their derivatives, the chiral and achiral diamine-based cyanides and their derivatives, the chiral and achiral amino alcohol-based cyanides and their derivatives, the Strecker nucleophiles that are derived from chiral and achiral hydroxyl carboxylic acids and amino acids. Methods of forming the electrophile for asymmetric Strecker reaction comprise the reactions with steps of: a) synthesizing phosphoryl chloride from achiral diamine; b) synthesizing phosphorous azide; c) synthesizing phosphoramide; d) synthesizing the corresponding achiral N-phosphonyl imines.

Abstract: Bisphosphonamidate prodrugs of therapeutic bisphosphonate compounds and uses thereof to treat diseases are described.

Abstract: It is reported herein that certain muscle diseases and conditions, including forms of muscular dystrophy, are characterized by impaired insulin-dependent signaling in the muscle tissue, in essence, a form of insulin resistance. The present disclosure relates to therapeutic agents, compositions and methods for treating a muscle disease or condition characterized by impaired insulin-dependent signaling by targeting components of the defective insulin signaling pathway. The disease or condition may be treated by administering a therapeutic agent that activates the insulin signaling pathway, in particular, therapeutic agents that act post-insulin receptor to modulate intracellular effector molecules. An exemplary modulator is metformin. Metformin may be administered alone or may be co-administered with another therapeutic agent for treating the muscle disease or condition, such as a corticosteroid.

Abstract: The present invention relates to a ligand and its use in a catalyst for the oligomerization of olefinic monomers, the ligand having the general formula (VI); (R9)(R10)P—N(R3)—P(R4)??(VI) wherein: the R9 and R10 groups are independently selected from optionally substituted alkyl or heteroalkyl groups; the R3 group is selected from hydrogen, a hydrocarbyl group, a substituted hydrocarbyl group, a heterohydrocarbyl group, a substituted heterohydrocarbyl group, a silyl group or derivative thereof; the R4 group is an optionally substituted alkylenedioxy, alkylenedimercapto or alkylenediamino structure which is bound to the phosphorus atom through the two oxygen, sulphur or nitrogen atoms of the alkylenedioxy, alkylenedimercapto or alkylenediamino structure or an optionally substituted arylenedioxy, arylenedimercapto or arylenediamino structure which is bound to the phosphorus atom through the two oxygen, sulphur or nitrogen atoms of the arylenedioxy, arylenedimercapto or arylenediamino structure.

Abstract: The invention relates to a method for producing 6-chlorodibenzo[d,f] [1,3,2]-dioxaphosphepin (formula 1), comprising the following steps: a) addition of liquid 2,2?-dihydroxybiphenyl into a reactor to an excess of phosphorous trichloride under inert gas and stirring; b) discharge and neutralization of the resulting gases from the reaction mixture; c) separation of the excess phosphorous trichloride; d) obtention of 6-chlorodibenzo[d,f] [1,3,2]-dioxaphosphepin.

Abstract: This invention relates to an additive for a non-aqueous electrolyte of an electric double layer capacitor comprising a combustion inhibiting substance releasing compound capable of releasing a combustion inhibiting substance having particularly excellent combustion inhibiting effect during combustion, and more particularly to an additive for a non-aqueous electrolyte of an electric double layer capacitor comprising a combustion inhibiting substance releasing compound which releases a combustion inhibiting substance during combustion, characterized in that the combustion inhibiting substance is a phosphine oxide compound having P—F bond and/or P—NH2 bond in its molecule.

Abstract: Certain cyclic phosphoramide ester compounds useful, inter alia, as halogen-free flame-retardant compounds, are disclosed. The compounds are particularly useful for providing flame retarded polyurethane foams.

Abstract: This invention relates to an additive for a non-aqueous electrolyte of an electric double layer capacitor comprising a combustion inhibiting substance releasing compound capable of releasing a combustion inhibiting substance having particularly excellent combustion inhibiting effect during combustion, and more particularly to an additive for a non-aqueous electrolyte of an electric double layer capacitor comprising a combustion inhibiting substance releasing compound which releases a combustion inhibiting substance during combustion, characterized in that the combustion inhibiting substance is a phosphine oxide compound having P—F bond and/or P—NH2 bond in its molecule.

Abstract: A method of synthesizing an ionic metal complex corresponding to formula (1) in which a compound of formula (2) and/or a compound of formula (3) E3-O—R2??(3) is reacted with a halogen containing compound in an organic solvent in the presence of a compound containing an element of group 1, group 2, group 13 or group 14 of the periodic table as a reaction aid.

Abstract: The present invention describes organophosphorus compounds of general formula (I) their preparation and their uses in the activation of gamma/delta T-cells, in the screening of GcpE and LytB enzyme inhibitors and in the prophylaxis and treatment of diseases in humans and animals.

Abstract: A silver halide color photosensitive material is disclosed, which has on a support at least one photosensitive silver halide emulsion layer, wherein at least one nondiffusible compound represented by the following formulas (I), (I-1), or (I-2) is contained to inhibit generation of color stain and color fog and to ensure excellent keeping quality: ##STR1## wherein Y.sup.1 represents atoms completing a phosphorus-containing heterocyclic ring; and ##STR2## wherein R.sup.1 represents an aryl group or a heterocyclic group; R.sup.2 represents an alkyl group, a cycloalkyl group, an aryl group (formula (I-2)), a heterocyclic group (formula CI-2)), an alkoxy group or an aryloxy group; A.sup.1 and A.sup.2 each represent a hydrogen atom or a hydrolyzable group; G represents a carbon atom or a phosphorus atom; X represents an oxygen atom or a sulfur atom; and R.sup.3 represents an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group.

Abstract: A process for extracting metal values, especially zinc values, from aqueous solutions of metal salts, which comprises contacting the aqueous solution with an organic phase comprising a compound of the formula, ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4, independently, represents an optionally substituted hydrocarbyl or hydrocarbyloxy group or R.sup.1 and R.sup.2 together with the attached phosphorus atom and/or R.sup.3 and R.sup.4 together with the attached phosphorus atom from a 5- to 8-membered heterocyclic ring.

Abstract: New phosphazene derivatives, fully substituted by aromatic groups and perfluoropolyethereal chains, are utilized as stabilizers for oils and greases based on perfluoropolyethers. Such derivatives inhibit the degradation process affecting the perfluoropolyethereal chains when these are subjected to high temperatures in an oxidizing atmosphere and in the presence of metals, such as for example aluminium, titanium, vanadium and their alloys, or steels.

Abstract: A compound useful for forming immunoconjugates used in the detection of organophosphate pesticides is provided. The compound has the formula ##STR1## wherein X is selected from the group consisting of R--O--, R--S-- and R--NH--, where R is an optionally substituted aromatic or heterocyclic group, or an optionally substituted alkyl or alkenyl group;Y is O or S;R.sup.1 is H or alkyl; andR.sup.2 is a group of the formula --(CH.sub.2).sub.n -- wherein n is an integer of from 1 to 10, or branched chain alkylene, or a group of the formula R.sup.3 --O--R.sup.4 wherein R.sup.3 and R.sup.4 are both or straight or branched chain alkylene;or a salt or ester thereof.

Abstract: A method of producing an ether-type thio-phospholipid of the formula (I): ##STR1## wherein: n is an integer of 13 to 17;A is C.sub.14 -C.sub.20 acyl group;G is a group selected from the group consisting of: ##STR2## which is useful as synthetic substrate of cytosolic phospholipase A.sub.2 inhibitors, said method being applicable to mass production of the compound (I), intermediates therefor and the preparation of the same are provided.

Abstract: Novel bleaches, a method for bleaching substrates using these materials and detergent compositions containing same are reported. The bleaches are phosphinoyl imines. Substrates such as fabrics may be bleached in an aqueous solution containing the phosphinoyl imines and a peroxygen compound.

Abstract: A process for continuously producing alkylpyrophosphonate, alkylpyrophosphate and multimers thereof and for producing 4-amino-1-hydroxyalkylidene-1,1-bisphosphonic acids or salts thereof.

Abstract: This invention relates to bisphosphoryl hydrazine compounds and to compositions thereof which are useful as pesticides. The compounds of this invention are effective against soil insects, especially the corn rootworm.

Abstract: A composition, having good weatherability properties, comprisinga) one or more compounds of formula I ##STR1## in which m is 1;n is 0 or 1;p is 0;each R or R.sup.1 independently, is a group derived from an aliphatic, alicyclic or aromatic alcohol containing one or two OH groups; whereby the two --OH groups are not positioned to be able to form a P-containing ring;or both groups R form a group derived from an aliphatic, alicyclic or aromatic alcohol containing two OH groups in such a position that they can form a cyclic group with a single phosphorus atom;Y is --O--, --S--, --CH(R.sub.5)-- or --C.sub.6 H.sub.4 --;where R.sub.5 is hydrogen or C.sub.1-8 alkyl or COOR.sub.6 and R.sub.6 is C.sub.1-8 alkyl; andb) a polymeric material.

Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with anhydrous hydrogen fluoride in an inert solvent, e.g., xylene, methylene chloride, in a manner such that said anhydrous hydrogen fluoride is added to said phosphorus compound at a rate such that said anhydrous hydrogen fluoride reacts with said phosphorus compound without the accumulation of an amount of unreacted anhydrous hydrogen fluoride which is sufficient to cause substantial decomposition of the desired fluorophosphorus product. A catalytic amount of a pyridine-type compound may optionally included in the reaction.

Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guadinine, isourea, isothiourea an biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phsophoric acid.

Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with a fluoride salt, e.g., KF, or ammonium fluoride in the presence of a hydrogen halide salt of a pyridine-type nitrogen base, e.g., pyridine hydrochloride.

Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with anhydrous hydrogen fluoride in an inert solvent, e.g., xylene, methylene chloride, in a manner such that said anhydrous hydrogen fluoride is added to said phosphorus compound at a rate such that said anhydrous hydrogen fluoride reacts with said phosphorus compound without the accumulation of an amount of unreacted anhydrous hydrogen fluoride which is sufficient to cause substantial decomposition of the desired fluorophosphorus product.

Abstract: New organic phosphorus compounds, comprised of hetero-phosphacycloalkanes whose phosphorus atom forms a complex with a borane. They can be prepared by the action of a borane on a hetero-phosphacycloalkane, within a solvent, at temperatures ranging from -20.degree. to +60.degree. C. Their transformation into other derivatives, phosphinites or phosphines in particular, can be carried out without any modification in the chirality of the initial complex. An especially useful application is their conversion into highly optically active phosphines, used in particular as catalysts in various reactions.

Abstract: Riboflavin-4',5'-cyclophosphoric acid chloride of the formula I ##STR1## its preparation by reacting an alkali metal salt of riboflavin, in an aprotic solvent, with phosphorus oxychloride, its use for the preparation of riboflavin-5'-phosphate and of the sodium salt of riboflavin-5'-phosphate, and a process for the preparation of riboflavin-5'-phosphate or its sodium salt via the novel phosphoric acid ester chloride.

Abstract: The invention is novel compounds of the formula: ##STR1## which are antagonists of platelet activating factor.

Abstract: A composition comprising an aromatic polycarbonate in admixture with an anti-yellowing effective amount of a compound of the formula ##STR1##

Abstract: A compound of formula: ##STR1## in which X.sup.1 is a reactive group that can react to form a covalent bond with a reactive group on the surface of a material to be rendered biocompatible, X.sup.2 is a group -0.sup..crclbar. or a precursor of such a group, n is 2, 3 or 4, Y is a group --N.sup..sym. R.sub.3 A.sup..crclbar. wherein each R, which may be the same or different, is a C.sub.1 -C.sub.4 alkyl group and A.sup..crclbar. is an anion present when X.sup.2 is an electrically neutral group or Y is ##STR2## wherein R.sup.1 together with X.sup.2 forms a direct bond between the nitrogen and the phosphorus atoms.

Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with a hydrogen fluoride salt of a pyridine-type nitrogen base, e.g. pyridine hydrofluoride in an inert solvent.

Abstract: Organic materials normally subject to gradual degradation in the presence of oxygen are stabilized by inclusion of an aromatic fluorophosphite having at least one benzene group bonded through oxygen to phosphorus and at least one fluorine atom bonded directly to the same phosphorus. Stabilization is improved by also including a conventional phenolic antioxidant. Many of the aromatic fluorophosphites are new compounds.

Abstract: Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are transhalogenated with fluorine by reaction with a fluoride salt, e.g., KF, or ammonium fluoride in an inert solvent in the presence of a catalytic amount of a carboxylic acid.

Abstract: Aryl fluorophosphites have been found to be effective polymer stabilizers and are hydrolytically stable when used to form aqueous suspensions.

Abstract: Organic materials normally subject to gradual degradation in the presence of oxygen are stabilized by inclusion of an aromatic fluorophosphite having at least one benzene group bonded through oxygen to phosphorus and at least one fluorine atom bonded directly to the same phosphorus. Stabilization is improved by also including a conventional phenolic antioxidant. Many of the aromatic fluorophosphites are new compounds.