Naphthyl In Acid Moiety Patents (Class 560/100)
  • Patent number: 10285960
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: May 14, 2019
    Assignee: IO Therapeutics, Inc.
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Patent number: 10201512
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: February 12, 2019
    Assignee: IO Therapeutics, Inc.
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Patent number: 10034845
    Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: July 31, 2018
    Assignee: lo Therapeutics, Inc.
    Inventors: Roshantha A. Chandraratna, Ethan Dmitrovsky, Elizabeth Nowak, Randolph Noelle
  • Patent number: 9018409
    Abstract: The present invention relates to a process for synthesizing a multifunctional compound, including the reaction of a compound of formula (II) with atmospheric or molecular oxygen, in the presence of at least one aldehyde of formula (III), and optionally in the presence of at least one catalyst or at least one radical initiator; wherein: R10, R20, R30, R40, R50, L2, R60, R7, R8, and R9 are as described in the claims. The invention also relates to the use of these compounds as monomers for the preparation of polyurethane. The invention also relates to the use of these compounds as monomers of polymers or of biopolymers.
    Type: Grant
    Filed: October 27, 2011
    Date of Patent: April 28, 2015
    Assignees: Meurice R&D ASBL, Centre National de la Recherche Scientifique, Université de Poitlers
    Inventors: Stefano Casciato, Yannick Pouilloux, Vincent Dubois
  • Patent number: 9005478
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 is hydrogen, halogen, cyano, alkoxy, NHCOR9, NHSO2R9, COOR9, OCOR9, aryl, alkyl, alkenyl, cycloalkyl, or heterocyclic all either substituted or unsubstituted; R4 is hydrogen, alkyl, aryl, alkenyl, cycloalkyl, or heterocyclic all either substituted or unsubstituted; R5, R6, R7, and R8 are independently hydrogen, halogen, cyano, alkoxy, NHCOR9, NHSO2R9, COOR9, OCOR9, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted, or combine with each other, or R5 can combine with R4 to form a carbocyclic or heterocyclic ring; R9 and R10 are independently alkyl, alkoxy, aryl, naphthyl, styryl, alkenyl, cycloalkyl, alko
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: April 14, 2015
    Assignees: Kent Displays Incorporated, Kent State University
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Patent number: 8968841
    Abstract: A binaphthyl compound represented by General Formula (G1) is provided. In General Formula (G1), Ar2 represents any of an arylene group, a cycloalkylene group, and a cycloalkenylene group, and m is any of 0 to 3; R3 represents any of hydrogen, an alkyl group, and an alkoxy group; and one of R and R1 represents a substituent represented by General Formula (G2) and the other thereof represents hydrogen. In General Formula (G2), Ar1 represents any of an arylene group, a cycloalkylene group, and a cycloalkenylene group, and k is any of 1 to 3; and R2 represents any of hydrogen, an alkyl group, and an alkoxy group.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: March 3, 2015
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Momoko Kato, Yasuhiro Niikura, Yuko Kawata, Tetsuji Ishitani
  • Patent number: 8883271
    Abstract: The present invention is to provide a novel polymerizable chiral compound (chiral agent) having high left-handed helical twisting power, a polymerizable liquid crystal composition comprising the polymerizable chiral compound and a polymerizable liquid crystal compound, a liquid crystal polymer, and an optically anisotropic body.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: November 11, 2014
    Assignee: Zeon Corporation
    Inventors: Kei Sakamoto, Kentaro Tamura, Kumi Okuyama
  • Publication number: 20140296561
    Abstract: A sulfonium salt having a 4-fluorophenyl group is introduced as recurring units into a polymer comprising hydroxyphenyl(meth)acrylate units and acid labile group-containing (meth)acrylate units to form a polymer which is useful as a base resin in a resist composition. The resist composition has a high sensitivity, high resolution and minimized LER.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Youichi OHSAWA, Masaki OHASHI, Seiichiro TACHIBANA, Jun HATAKEYAMA
  • Publication number: 20140155632
    Abstract: The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.
    Type: Application
    Filed: February 27, 2012
    Publication date: June 5, 2014
    Inventors: Thomas Himmler, Lukas J. Goossen, Felix Rudolphi, Bingrui Song
  • Patent number: 8742005
    Abstract: The present invention relates to an acrylate-based compound that includes an organic acid having two or more acrylate groups and one or more phenolic acid structures in one molecule, and a photosensitive composition including the same. It is possible to shorten a developing time in a photolithography process without damaging photosensitivity by using the photosensitive composition according to the present invention.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: June 3, 2014
    Assignee: LG Chem, Ltd.
    Inventors: Keon Woo Lee, Sang Kyu Kwak, Changsoon Lee, Hyehyeon Kim
  • Patent number: 8709281
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; and R3-R9 are as described in the disclosure. Also featured are liquid crystal compositions comprising a chiral dopant compound represented by any of Structure 2-4 as described in the disclosure.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: April 29, 2014
    Assignee: Kent State University
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Patent number: 8647878
    Abstract: The invention relates to an immersion liquid including at least one compound of the general formula I in which R1 and R2 each include at least one ring structure and X denotes: O, S, NR3 with R3 selected from hydrogen or hydrocarbon, wherein Y denotes independently of each other O, S or NR4 with R4 selected from hydrogen or hydrocarbon. In addition, the invention relates to a further immersion liquid, a compound for an immersion liquid and a use of the immersion liquids or of the compound as an immersion oil for a microscope, in particular for a near-field microscope.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: February 11, 2014
    Assignee: Carl Zeiss AG
    Inventor: Hans-Joachim Weippert
  • Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Publication number: 20130331446
    Abstract: The invention relates to compounds of general formula I, (I), wherein R is wherein R is aryl substituted by R3; or R is (C3-Ci3)-cycloalkyl, (C3-Ci3)-cycloalkenyl or (C7-Ci3)-cycloalkynyl optionally substituted by R4; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
    Type: Application
    Filed: December 22, 2011
    Publication date: December 12, 2013
    Applicant: LEO LABORATORIES LIMITED
    Inventors: Gunnar Grue-Sørensen, Xifu Liang, Thomas Högberg, Kristoffer Månsson, Per Vedsø
  • Publication number: 20130315841
    Abstract: Methods for the synthesis and use of functionalized, substituted naphthalenes are described. The functionalized, substituted naphthalenes display useful properties including liquid crystals and fluorescence properties, such as solvatochromatic fluorescence, with high quantum yields, Stoke's shift, and show emission maxima that are significantly red-shifted.
    Type: Application
    Filed: March 15, 2013
    Publication date: November 28, 2013
    Inventor: Kay M. Brummond
  • Publication number: 20130303798
    Abstract: A production process for substituted phenylacetic acids or ester analogues thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogues thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.
    Type: Application
    Filed: December 20, 2012
    Publication date: November 14, 2013
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventor: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
  • Patent number: 8524952
    Abstract: A modified dimethylnaphthalene formaldehyde resin obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: September 3, 2013
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Seiji Kita, Masashi Ogiwara, Mitsuharu Kitamura, Dai Oguro, Gou Higashihara
  • Patent number: 8519177
    Abstract: A modified dimethylnaphthalene formaldehyde resin obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: August 27, 2013
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Seiji Kita, Masashi Ogiwara, Mitsuharu Kitamura, Dai Oguro, Gou Higashihara
  • Patent number: 8501981
    Abstract: The invention relates to compounds of the formula I in which R1, R2, X, A, B, Z and Y1 to Y4 have the meanings indicated in the claims, and/or a pharmaceutically acceptable salt and/or a prodrug thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts and prodrugs thereof are suitable for the prevention and treatment of chemokine mediated diseases.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: August 6, 2013
    Assignee: SANOFI
    Inventors: Stephanie Hachtel, Juergen Dedio, Elisabeth DeFossa, Sven Grueneberg, Holger Heitsch, William Bock, Charlie Chen, Raymond Kosley, Chung-Yi Kung, Marcel Patek, Rosy Sher, Stephen Shimshock, Aleksandra Weichsel
  • Publication number: 20130172558
    Abstract: Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compounds, which can be used in liquid crystal compositions useful for electro-optical and display device applications. The liquid crystal can be a ferroelectric liquid crystal. Also provided is a display device that includes the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound. Also provided is a method of preparing a liquid crystal display device on silicon that includes incorporating the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound, into a liquid crystal display on silicon by disposing the compound in a liquid crystal, or the liquid crystal, onto a silicon surface.
    Type: Application
    Filed: January 4, 2012
    Publication date: July 4, 2013
    Inventors: Yongqiang Zhang, Kundalika More, William Thurmes
  • Publication number: 20130157195
    Abstract: A molecular glass compound includes (A) a tetrameric reaction product of a specific aromatic compound having at least one hydroxy group, and a specific polycyclic or fused polycyclic aromatic aldehyde; and (B) an acid-removable protecting group as an adduct with the hydroxy group of the aromatic compound and/or a hydroxy group of the polycyclic or fused polycyclic aromatic aldehyde. A photoresist composition including the molecular glass compound, and a coated substrate including a layer of the photoresist composition are also disclosed.
    Type: Application
    Filed: September 21, 2012
    Publication date: June 20, 2013
    Applicant: ROHM AND HAAS ELECTRONIC MATERIALS LLC
    Inventor: Rohm and Haas Electronic Materials LLC
  • Publication number: 20130078569
    Abstract: A molecular glass compound comprises a vinyl ether adduct of an aromatic vinyl ether of formula C(R1)2?C(R2)—O-(L)n-Ar1, and a calix[4]arene, wherein R1 and R2 are each independently a single bond, H, C1-20 alkyl, C1-20 haloalkyl, C6-20 aryl, C6-20 haloaryl, C7-20 aralkyl, or C7-20 haloaralkyl, L is a C1-20 linking group, n is 0 or 1, and Ar1 is a halo-containing monocyclic, or substituted or unsubstituted polycyclic or fused polycyclic C6-20 aromatic-containing moiety, wherein R1 and R2 are connected to Ar1 when either or both of R1 and R2 is a single bond and n is 0. A photoresist, comprising the molecular glass compound, a solvent, and a photoacid generator, a coated substrate, comprising (a) a substrate having one or more layers to be patterned on a surface thereof; and (b) a layer of a photoresist composition over the one or more layers to be patterned, and a method of forming the molecular glass compound, are also disclosed.
    Type: Application
    Filed: September 21, 2012
    Publication date: March 28, 2013
    Applicants: DOW GLOBAL TECHNOLOGIES LLC, ROHM AND HAAS ELECTRONIC MATERIALS LLC
    Inventors: Rohm and Haas Electronic Materials LLC, Dow Global Technologies LLC
  • Patent number: 8344175
    Abstract: The invention relates to compounds of Formula (I): The invention further relates to liquid crystal compositions comprising compounds of Formula (I); compositions further comprising one or more chiral compounds; and polymer networks derived from the polymerization of the liquid crystal compositions. Another embodiment relates to processes for providing compounds of Formula (I).
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: January 1, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Marc B. Goldfinger, Jose Manuel Rodriguez-Parada, Lee A. Silverman
  • Publication number: 20120302752
    Abstract: Methods are described for efficient and regioselective reactions that are Ru-catalyzed and either (i) amide-directed C—H, C—N, C—O activation/C—C bond forming reactions, (ii) ester-directed C—O and C—N activation/C—C bond forming reactions, or (iii) amide-directed C—O activation/hydrodemethoxylation reactions. All of these reactions of directed C—H, C—N, C—O activation/coupling reactions establish a catalytic base-free DoM-cross coupling process at non-cryogenic temperature. High regioselectivity, yields, operational simplicity, low cost, and convenient scale-up make these reactions suitable for industrial applications. Many previously unknown amide-substituted or ester-substituted aryl and heteroaryl compounds are presented with synthetic details also provided.
    Type: Application
    Filed: May 24, 2012
    Publication date: November 29, 2012
    Inventors: Yigang Zhao, Victor A. Snieckus
  • Patent number: 8304513
    Abstract: Disclosed are polyesters, particularly poly(trimethylene terephthalate), comprising fluorovinylether functionalized aromatic repeat units, and methods to make the polyester polymers. The polymers are useful for imparting soil resistance to polyesters, particularly in the form of fibers, fabrics, and carpets.
    Type: Grant
    Filed: September 1, 2010
    Date of Patent: November 6, 2012
    Assignee: E I du Pont de Nemours and Company
    Inventors: Neville Everton Drysdale, Surbhi Mahajan, Kenneth Gene Moloy, Fredrik Nederberg, Joel M. Pollino, Joachim C. Ritter
  • Patent number: 8282872
    Abstract: It's object is to provide a (meth)acrylate compound excellent in photocurability, a curable composition comprising the compound and excellent in all of pattern accuracy, peelability, surface hardness, elasticity recovery and solvent resistance, an optical nanoimprint composition and a cured product of the curable composition and a method for producing it, especially to provide a composition favorable for a permanent film for flat panel displays, etc. A (meth)acrylate compound represented by the following formula (1): wherein R1 represents a hydrogen atom or a methyl group, R2 represents a substituent having carbon atoms of 2 to 6 and having a carbon-carbon double bond, X represents an organic group having carbon atoms of 1 to 10, m and n each are an integer of 1 to 3.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: October 9, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Akinori Fujita, Takashi Takayanagi, Hiroyuki Yonezawa
  • Patent number: 8273769
    Abstract: The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: September 25, 2012
    Assignee: Merck Serono SA
    Inventors: Stefano Crosignani, Catherine Jorand-Lebrun, Christophe Cleva, Adeline Pretre
  • Publication number: 20120101039
    Abstract: A compound of general formula I their use as calcium receptor-active compounds for the prophylaxis, treatment or amelioration of physiological disorders or diseases associated with disturbances of CaSR activity, such as hyperparathyroidism, pharmaceutical compositions comprising said compounds, methods of treating diseases with said compounds, and the use of said compounds in the manufacture of medicaments.
    Type: Application
    Filed: May 26, 2010
    Publication date: April 26, 2012
    Applicant: LEO PHARMA A/S
    Inventors: Jef Fenscholdt, Thomas Høyer, Xifu Liang, Sophie Elisabeth Havez
  • Publication number: 20120095048
    Abstract: The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment including these compounds.
    Type: Application
    Filed: February 19, 2010
    Publication date: April 19, 2012
    Applicants: REGION MIDT JYLLAND, AARHUS UNIVERSITET
    Inventors: Henrik Amtoft Neubauer, Ove Kjaer Wiborg, Henrik Helligsø Jensen
  • Publication number: 20120076954
    Abstract: Disclosed therein are a cyclic olefin compound, a photoreactive polymer, and an alignment layer comprising the photoreactive polymer, where the cyclic olefin compound can be used to provide the photoreactive polymer having not only excellences in liquid crystal alignment and alignment rate but also readiness for change in the alignment direction depending on the polarization direction.
    Type: Application
    Filed: September 23, 2011
    Publication date: March 29, 2012
    Applicant: LG CHEM, LTD.
    Inventors: Dong-Woo YOO, Sung-Ho Chun, Dai-Seung Choi, Sung-Kyoung Lee
  • Patent number: 8115008
    Abstract: Disclosed is a method for producing an optically active ester by highly selectively esterifying one enantiomer of a racemic carboxylic acid, while producing an optically active carboxylic acid which is the other enantiomer. An optically active ester is produced while producing an optically active carboxylic acid at the same time by reacting a racemic carboxylic acid with a specific alcohol or phenol derivative in the presence of benzoic anhydride or a derivative thereof and a catalyst such as tetramisole or benzotetramisole, thereby selectively esterifying one enantiomer of the racemic carboxylic acid.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: February 14, 2012
    Assignee: Tokyo University of Science Education Foundation Administrative Organization
    Inventors: Isamu Shiina, Kenya Nakata
  • Publication number: 20120004413
    Abstract: A radioisotope labeled reagent includes a compound having the general formula (I), L-(aCbH2)naC5bH3??(I) where a in each occurrence independently is a carbon mass number between 11 and 14 inclusive, b in each occurrence independently is a hydrogen mass number between 1 and 3 inclusive, such that a in each occurrence is not 12 simultaneously with b in each occurrence being 1; L is a leaving group R1SO2—O—, R1—S—, 12C1H3(12C1H2)n—S—R1C(O)O—, NC—, (R1)3P—, XMg— and Li—, where n is an integer between 0 and 3 inclusive, where X is chloro, bromo or iodine, where R1 is H, aryl, a substituent containing aryl, C1-C20 alkyl, a substituent containing C1-C20 alkyl, C2-C20 alkenyl, a substituent containing C2-C20 alkenyl, C2-C20 alkynyl, and a substitute containing C2-C20 alkynyl with the proviso that when n is 0, a is 13 and b is 2 and R1 in R1—S is not aryl.
    Type: Application
    Filed: September 13, 2011
    Publication date: January 5, 2012
    Applicant: PerkinElmer Health Sciences, Inc.
    Inventor: Jerry Scot Pounds
  • Patent number: 8044228
    Abstract: This invention relates to liquid crystal compositions, and polymer networks and articles comprising the compositions. The compositions comprise at least one compound of the group of compounds represented by the structures of each of the following Formulas (IV), (V) and (VI), as defined herein. A process for making the composition is also provided.
    Type: Grant
    Filed: June 8, 2009
    Date of Patent: October 25, 2011
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Marc B. Goldfinger
  • Publication number: 20110184180
    Abstract: The present invention relates to a novel process for preparing ?-arylmethylcarbonyl compound of the formula (III), characterized in that aryl- and heteroarylacetic acids and derivatives thereof of the formula (I) are reacted with ?-halomethylcarbonyl compounds of the formula (II) in the presence of a palladium catalyst, of a phosphine ligand, of an inorganic base and of a phase transfer catalyst, optionally using an organic solvent.
    Type: Application
    Filed: January 19, 2011
    Publication date: July 28, 2011
    Applicant: Bayer CropScience AG
    Inventors: Thomas HIMMLER, Lukas J. GOOBEN, Bettina ZIMMERMANN
  • Patent number: 7973200
    Abstract: The invention relates to the use as perfuming ingredients of 8a-alkyl-perhydro-naphthalenol derivatives, to impart odor notes of the woody-earthy type.
    Type: Grant
    Filed: October 29, 2008
    Date of Patent: July 5, 2011
    Assignee: Firmenich SA
    Inventors: Robert Moretti, Olivier Etter
  • Patent number: 7943795
    Abstract: The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, ZP, LP1, LP2 LNP, RP3, RN, and ZNP are defined herein, their preparation, pharmaceutical compositions, and methods of use.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: May 17, 2011
    Assignee: Eli Lilly and Company
    Inventors: Lynn Stacy Gossett, Jose Eduardo Lopez, Alan M. Warshawsky, Ying Kwong Yee
  • Publication number: 20110077406
    Abstract: Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize unconventional phenol derivatives as cross-coupling partners. Embodiments of the invention can be used to synthesize a variety of useful organic compounds, for example the anti-inflammatory drug flurbiprofen.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 31, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Neil K. Garg, Kyle W. Quasdorf, Xia Tian
  • Publication number: 20100212547
    Abstract: The invention relates to an immersion liquid including at least one compound of the general formula I in which R1 and R2 each include at least one ring structure and X denotes: O, S, NR3 with R3 selected from hydrogen or hydrocarbon, wherein Y denotes independently of each other O, S or NR4 with R4 selected from hydrogen or hydrocarbon. In addition, the invention relates to a further immersion liquid, a compound for an immersion liquid and a use of the immersion liquids or of the compound as an immersion oil for a microscope, in particular for a near-field microscope.
    Type: Application
    Filed: February 24, 2010
    Publication date: August 26, 2010
    Inventor: Hans-Joachim Weippert
  • Patent number: 7771616
    Abstract: A polymerizable liquid crystal compound of formula (1). The compound has high optical (refractive index) anisotropy (?n), exhibits a liquid crystal phase at room temperature (having a broad liquid crystal phase temperature range) without crystallization, has high solubility in cyclohexanone, methyl ethyl ketone or like organic solvents, exhibits excellent coating properties and orientation properties, and, after polymerization, has high transparency. wherein R1 and R2 each represent hydrogen, a methyl group or halogen; rings A to C each represent a benzene ring, a naphthalene ring, etc.; at least one of rings A to C is a fused ring; X, Y, and Z each represent a C1 to C6 alkyl group, etc.; L1, L2, and L3 each represent —COO—, —OCO—, —O(CH2)j— (j=1 to 8), etc.; n is 0 or 1, and a to c are numbers such that the polymerizable liquid crystal compound may have at least one of X, Y, and Z.
    Type: Grant
    Filed: August 24, 2006
    Date of Patent: August 10, 2010
    Assignee: Adeka Corporation
    Inventors: Masatomi Irisawa, Tatsunori Kobayashi, Mineki Hasegawa
  • Patent number: 7754912
    Abstract: A novel polymerizable compound of the present invention is represented by the following general formula (I). Due to the presence of a reactive phenolic hydroxyl group at the end of the molecule, it can be reacted easily with various functional compounds and is useful as a monomer and an intermediate for various functional materials, especially as an intermediate for a polymerizable liquid crystal material. wherein R1 is a hydrogen atom, a methyl group or a halogen atom; R2 is an optionally substituted alkyl group having 1 to 6 carbon atoms, an optionally substituted alkoxy group having 1 to 6 carbon atoms, a halogen atom or a cyano group; an alkylene group of each of the alkyl and the alkoxy group may be interrupted by an unsaturated bond, an ether bond, a thioether bond or an ester bond; n is an integer from 0 to 14; and m is 0 or 1.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: July 13, 2010
    Assignee: Adeka Corporation
    Inventors: Masatomi Irisawa, Tatsunori Kobayashi, Mineki Hasegawa
  • Publication number: 20100157202
    Abstract: A polymer compound which is useful as a light emitting material and a charge transporting material and excellent in electron injection property, comprising as a partial structure therein a structure of the following formula (a) is provided: (wherein, a ring A and a ring B represent each independently an aromatic ring or a non-aromatic ring, and at least one of the ring A and the ring B is an aromatic ring. A ring C represents an aromatic ring. Z1 represents an atom selected from a carbon atom, oxygen atom, sulfur atom, nitrogen atom, silicon atom, boron atom, phosphorus atom and selenium atom or a group containing the atom, and Z2 to Z6 represent each independently an atom selected from a carbon atom, silicon atom, nitrogen atom and boron atom or a group containing the atom.).
    Type: Application
    Filed: November 9, 2006
    Publication date: June 24, 2010
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Shigeya Kobayashi, Satoshi Kobayashi
  • Patent number: 7682522
    Abstract: The invention includes compounds represented by Formula (1): wherein R represents hydrogen or methyl; A represents alkylene having from 1 to 12 carbon atoms, wherein in the alkylene, arbitrary —CH2— may be replaced by —O—, —S—, —CH?CH—, —CO—, —COO— or —OCO—; X and Y each independently represent an aromatic ring or a cyclohexane ring, wherein in the rings, arbitrary hydrogen may be replaced by alkyl having from 1 to 3 carbon atoms; Z independently represents a single bond, —O—, —S—, —COO—, —OCO—, —CON(R1)— or —N(R1)CO—, wherein R1 represents hydrogen or methyl; and m represents an integer of from 0 to 3.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: March 23, 2010
    Assignees: Chisso Corporation, Chisso Petrochemical Corporation
    Inventor: Mayumi Tanabe
  • Patent number: 7683203
    Abstract: The polymerizable compound of the present invention is represented by general formula (1) below and can provide a composition that is polymerizable near ambient temperature and exists in a liquid crystal phase at low temperatures. The composition and a (co)polymer of the polymerizable compound of the present invention are liquid crystal substances useful as optically anisotropic materials. (In the formula, each of rings A1 to A3 represents a benzene ring, cyclohexane ring, etc.; each of X to Z represents a C1-8 alkyl or alkoxy group, C2-6 alkenyl group, halogen atom, cyano group, or CH2?CR3—COO—; each of R1 to R3 represents a hydrogen atom, methyl group, or halogen atom; each of L1 to L3 represents —CH2CH2COO—, —COO—, —OCO—, —CH2CH2—, —O(CH2)f— (herein, f=1-8), etc.; n represents 0 or 1; and a to c represent such numbers that the polymerizable compound has at least one or more of any of X, Y, and Z).
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: March 23, 2010
    Assignee: Adeka Corporation
    Inventors: Masatomi Irisawa, Tatsunori Kobayashi, Mineki Hasegawa
  • Publication number: 20100056507
    Abstract: The present invention relates to new phenylic derivatives exhibiting a good affinity for certain sub-types of cannabinoid receptors, in particular the CB2 receptors. These derivatives are of particular interest in a method for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said new phenylic derivatives and to methods for the preparation and use thereof.
    Type: Application
    Filed: October 26, 2007
    Publication date: March 4, 2010
    Applicant: IPSEN PHARMA S.A.S.
    Inventors: Lydie Poitout, Jeremiah Harnett, Dennis Bigg, Carole Sackur, Eric Ferrandis
  • Patent number: 7670505
    Abstract: Compounds of the general formula I (variables defined herein) and processes for making compounds including 2,6 -naphthyl radicals are provided. Polymerizable or nonpolymerizable liquid-crystalline compositions including one or more compounds including 2,6 -naphthyl radicals, and products and processes employing such compositions, are also provided.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: March 2, 2010
    Assignee: BASF Aktiengesellschaft
    Inventors: Olivier Enger, Ruediger Sens, Christian Lennartz, Robert Parker
  • Patent number: 7666524
    Abstract: The present invention provides a novel material capable of realizing excellent color purity of blue, a light-emitting element and a light-emitting device using the novel material. The present invention provides an oligonaphthalene derivative represented by the formula (1). The oligonaphthalene derivatives of the present invention have an extremely large band gap, can emit light with extremely short wavelength, and can emit blue light with favorable color purity. In addition, a light-emitting element that can exhibit excellent color purity of blue can be obtained by applying this material to the light-emitting element or a light-emitting device; therefore the light-emitting element having superior color reproducibility can be provided.
    Type: Grant
    Filed: October 14, 2005
    Date of Patent: February 23, 2010
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Harue Nakashima, Sachiko Kawakami, Ryoji Nomura
  • Publication number: 20090297979
    Abstract: The present invention provides; a polymer suitable as a base resin for a positive resist composition, in particular a chemically amplified positive resist composition, having a higher resolution, a larger exposure allowance, a smaller sparse-dense size difference, a better process applicability, a better pattern configuration after exposure, and in addition, a further excellent etching resistance, than a conventional positive resist; a positive resist composition using the same; a patterning process; and a novel polymerizable compound to obtain a polymer like this. The present invention was accomplished by a polymer whose hydrogen atom of at least a carboxyl group is substituted by an acid labile group represented by the following general formula (2), a positive resist composition using the same, a patterning process, and a novel polymerizable compound to obtain a polymer like this.
    Type: Application
    Filed: May 18, 2009
    Publication date: December 3, 2009
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Takeru Watanabe, Seiichiro Tachibana
  • Patent number: 7615669
    Abstract: The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: November 10, 2009
    Assignee: Tosoh F-Tech, Inc.
    Inventors: Norihisa Kondo, Akio Watanabe, Hiroki Kanezaki, Kosuke Kawada
  • Patent number: 7592492
    Abstract: The present invention relates to the use as perfuming ingredients of certain derivatives of perhydro-1-naphthalenol of formula: wherein, in particular, each R represents a hydrogen atom or a methyl group, R1 and R3 represent a methyl or ethyl group, and R2 represents a hydrogen atom or a lower acyl group.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: September 22, 2009
    Assignee: Firmenich SA
    Inventors: Robert Moretti, Olivier Etter
  • Publication number: 20090215978
    Abstract: A process for the alkoxyalkylation of an unsubstituted aromatic substrate or a substituted aromatic substrate, said substitution being via a carbon-carbon bond, said process comprising reacting the aromatic substrate with a dialkoxyalkane in the presence of a catalyst.
    Type: Application
    Filed: February 21, 2006
    Publication date: August 27, 2009
    Applicant: Davy Process Technology Limited
    Inventors: Simon Darby Roberts, Stephan William Colley