Rings Bonded Directly To Each Other In Phenolic Moiety Patents (Class 560/141)
  • Patent number: 11312817
    Abstract: An alternative polyurethane composition is provided which comprises a reaction product of an azidated polyol and a poly(alkynyl carbamate) prepolymer reacted at a temperature of from 20° C. to 120° C., wherein the poly(alkynyl carbamate) prepolymer comprises a reaction product of a polyisocyanate and a stoichiometric equivalent of an alkynol of the formula (I), HC?C—R1R2—OH??(I), and wherein R1 is an electron-withdrawing group selected from the group consisting of carbonyl, ester, amide, and urethane and R2 is a linear or branched alkyl chain having from 1 to 15 carbon atoms. The inventive alternative polyurethane composition position may be used to provide adhesives, sealants, films, elastomers, castings, foams, and composites.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: April 26, 2022
    Assignees: Covestro LLC, The University Of Southern Mississippi
    Inventors: Robson F. Storey, Alan Ekin, R. Hunter Cooke, III, Jie Wu
  • Patent number: 10729681
    Abstract: The present disclosure relates to HIF-1? prolyl hydroxylase inhibitors, compositions which comprise the HIF-1? prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.
    Type: Grant
    Filed: August 31, 2018
    Date of Patent: August 4, 2020
    Assignee: Akebia Therapeutics, Inc.
    Inventors: Richard Masaru Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon
  • Patent number: 9428431
    Abstract: Provided are compositions including (3R, 4R, 6R)-stereoisomers of phenyl substituted pinenes having CB receptor agonist properties, methods of treating diseases or disorders with the pharmaceutical compositions, and processes for their preparation are also provided.
    Type: Grant
    Filed: October 11, 2009
    Date of Patent: August 30, 2016
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd.
    Inventors: Itai Bab, Raphael Mechoulam, Aviva Breuer, Naama Mussai
  • Patent number: 8840807
    Abstract: To provide a polymerizable compound having a high solubility in a liquid crystal composition, and laterally having a ring structure; a liquid crystal composition containing the compound, and a liquid crystal display device using the composition; and the polymerizable compound includes a compound represented by formula (1): wherein, for example, R1 is hydrogen or alkyl having 1 to 20 carbons, R2 and R3 are each independently hydrogen or methyl; A1 and A2 are a single bond, 1,4-phenylene or 1,4-cyclohexylene; Z1 is a single bond or alkylene having 1 to 3 carbons, Z2 is —O—, —COO—, —OCO— or alkylene having 1 to 6 carbons, Z3 is a single bond or —O—, Z4 is a single bond or alkylene having 2 to 20 carbons; X1 is hydrogen, halogen or alkyl having 1 to 3 carbons; and a is 0 or 1.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: September 23, 2014
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Maiko Ito
  • Patent number: 8822531
    Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are honokiol analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers. Representative honokiol analogs include diepoxide honokiol analogs. The compounds are believed to function, at least, by inhibiting angiogenesis and/or inducing apoptosis. Thus, the compounds are novel therapeutic agents for a variety of cancers.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: September 2, 2014
    Inventor: Jack L. Arbiser
  • Publication number: 20140008570
    Abstract: The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising them, and to the use of the polymerizable compounds and LC media for optical, electro-optical and electronic purposes, in particular in LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Application
    Filed: July 3, 2013
    Publication date: January 9, 2014
    Applicant: Merck Patent GmbH
    Inventors: Andreas TAUGERBECK, Martin ENGEL
  • Publication number: 20130277609
    Abstract: A compound represented by formula (1), a liquid crystal composition, a liquid crystal display device are described. In formula (1), for example, the ring A1 and the ring A4 are phenylene or cyclohexylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 6 carbons; L1 is a single bond; s and t are 0; and P1, P2, P3 and P4 are a polymerizable group.
    Type: Application
    Filed: December 23, 2012
    Publication date: October 24, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: YASUYUKI GOTO, MAIKO MATSUKUMA, JUNICHI YAMASHITA
  • Publication number: 20130048912
    Abstract: To provide a polymerizable compound having a high solubility in a liquid crystal composition, and laterally having a ring structure; a liquid crystal composition containing the compound, and a liquid crystal display device using the composition; and the polymerizable compound includes a compound represented by formula (1): wherein, for example, R1 is hydrogen or alkyl having 1 to 20 carbons, R2 and R3 are each independently hydrogen or methyl; A1 and A2 are a single bond, 1,4-phenylene or 1,4-cyclohexylene; Z1 is a single bond or alkylene having 1 to 3 carbons, Z2 is —O—, —COO—, —OCO— or alkylene having 1 to 6 carbons, Z3 is a single bond or —O—, Z4 is a single bond or alkylene having 2 to 20 carbons; X1 is hydrogen, halogen or alkyl having 1 to 3 carbons; and a is 0 or 1.
    Type: Application
    Filed: May 9, 2011
    Publication date: February 28, 2013
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventor: Maiko Ito
  • Patent number: 8313669
    Abstract: The present invention relates to a liquid-crystal (LC) display of the PS (polymer stabilized) or PSA (polymer sustained alignment) type, and to polymerizable compounds and LC media for use in PS (polymer stabilized) and PSA displays.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: November 20, 2012
    Assignee: Merck Patent Gesellschaft mit Beschränkter Haftung
    Inventors: Georg Bernatz, Andreas Taugerbeck
  • Publication number: 20120182516
    Abstract: The present invention relates to polymerisable compounds, to processes and intermediates for the preparation thereof, and to the use thereof for optical, electro-optical and electronic purposes, in particular in liquid-crystal (LC) media and LC displays, especially in LC displays of the PS (“polymer sustained”) or PSA (“polymer sustained alignment”) type.
    Type: Application
    Filed: August 30, 2010
    Publication date: July 19, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Andreas Taugerbeck, Achim Goetz
  • Publication number: 20120175549
    Abstract: The present invention provides a thermally-conductive organic additive which (i) is an organic polymer, unlike a thermally-conductive inorganic filler such as ceramic, metal and a carbon material, (ii) is capable of imparting thermal conductivity to plastic by being added thereto, (iii) can reduce the weight of a composition even when added to a resin in a large amount, without causing abrasion on molds and deteriorating an electrical insulation property of the composition, and (iv) provides the composition with excellent molding processability. The present thermally-conductive organic additive includes a liquid crystalline thermoplastic resin which has a mainly-chain structure, wherein a main chain of the liquid crystalline thermoplastic resin contains mainly a repeating unit represented by the general formula (1): -M-Sp-??(1) wherein M represents a mesogenic group; and Sp represents a spacer, the liquid crystalline thermoplastic resin itself having thermal conductivity of not less than 0.45 W/(m·K).
    Type: Application
    Filed: April 26, 2010
    Publication date: July 12, 2012
    Applicant: KANEKA CORPORATION
    Inventors: Shusuke Yoshihara, Kazuaki Matsumoto
  • Publication number: 20120108549
    Abstract: Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.
    Type: Application
    Filed: April 15, 2010
    Publication date: May 3, 2012
    Inventors: Balaraman Kalyanaraman, Joy Joseph, Anumantha Kanthasamy
  • Patent number: 8043789
    Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: October 25, 2011
    Assignee: Dongjin Semichem Co., Ltd.
    Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
  • Patent number: 7947423
    Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula 1. Also, the photoresist composition comprises 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 200 to 5000 weight parts of an organic solvent. In the formula 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, and R and R? are independently a chain type or a ring type of aliphatic or aromatic hydrocarbon group of 1 to 30 carbon atoms.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: May 24, 2011
    Assignee: Dongjin Semichem Co., Ltd.
    Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
  • Publication number: 20110101269
    Abstract: The present invention relates to a liquid-crystal (LC) display of the PS (polymer stabilised) or PSA (polymer sustained alignment) type, and to polymerisable compounds and LC media for use in PS (polymer stabilised) and PSA displays.
    Type: Application
    Filed: July 31, 2008
    Publication date: May 5, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Georg Bernatz, Andreas Taugerbeck
  • Publication number: 20110080551
    Abstract: A polymerizable monomer adopted to a display panel is represented as following chemical formula: wherein, m?0; “Z” is selected from oxygen, sulfur, carbonyl, caroboxyl, methyoxy, methylthio, thio, ethenylcarbonyl, carbonylethenyl, difluoromethoxy, difluoro methylthio, ethyl, difluoroethane, 1,2 difluoroethane, vinylene, difluoroethenylene, ethynyl, or single bond. “X1” and “X2” are independently selected from oxygen, sulfur, methyoxy, carbonyl, caroboxyl, -carbamoyl, methylthio, ethenylcarbonyl, carbonylethenyl, or single bond. “Sp1” and “Sp2” are independently a spacer or single bond. “P1” and “P2” are independently a polymerizable group.
    Type: Application
    Filed: May 25, 2010
    Publication date: April 7, 2011
    Applicant: AU OPTRONICS CORP.
    Inventors: Chung-Ching Hsieh, Yang-Chu Lin, Hsi-Chien Lin, Te-Sheng Chen
  • Publication number: 20100310615
    Abstract: The invention relates to compositions comprising pholyphenol derivatives, characterised in that said polyphenols contain monomers, oligomers or polymers with units having formula (I), said units being characterised by the simultaneous presence of a resorcinol nucleus (nucleus A) and a para-phenol nucleus (nucleus B) which are interconnected by a carbon bond C, said derivatives being over-activated, in respect of the nucleophilic power thereof, by alkylation of at least one phenol function of each constituent monomer unit and stabilised by sterification by mixtures of fatty acids in proportions reflecting those of vegetable oils formed mainly by unsaturated fatty acids of all of the other phenol functions. The invention is suitable for use in cosmetics, dietetics and therapeutics.
    Type: Application
    Filed: November 17, 2008
    Publication date: December 9, 2010
    Inventor: Joseph Vercauteren
  • Publication number: 20100308265
    Abstract: This invention relates to liquid crystal compositions, and polymer networks and articles comprising the compositions. The compositions comprise at least one compound of the group of compounds represented by the structures of each of the following Formulas (IV), (V) and (VI), as defined herein. A process for making the composition is also provided.
    Type: Application
    Filed: June 8, 2009
    Publication date: December 9, 2010
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventor: MARC B. GOLDFINGER
  • Patent number: 7456310
    Abstract: Disclosed herein is a cyclic dispersant having a rigid block which has a high affinity for carbon nanotubes, and a flexible block which has a high affinity for a solvent, with a linkage created therebetween. Having a structure that is advantageous with respect to adsorption to carbon nanotubes, the dispersant, even if used in a small amount, can disperse a large amount of carbon nanotubes.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: November 25, 2008
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Kwang Hee Kim, Jae Young Choi, Seon Mi Yoon, Hyuk Soon Choi, Hyo Sug Lee
  • Patent number: 6527690
    Abstract: The invention relates to a process for purifying and decolorizing a phenyl ester salt. The process combines a phenyl ester salt with a solvent to form a mixture and then stirs the mixture to form a slurry. The phenyl ester salt is substantially insoluble in this solvent. The process then collects the phenyl ester salt from the slurry. The collected phenyl ester salt may then be optionally dried or recrystallized. The collected phenyl ester salt is dissolved in a solvent to form a solution. The solution is decolorized and then spray dried to form a powder of the phenyl ester salt. As a result of the process the phenyl ester salt powder has a higher purity and an improved color as compared to the starting phenyl ester salt.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: March 4, 2003
    Inventors: Bhaskar Krishna Arumugam, Michael Eugene Burns, Dimmick Lee Bymaster, Jeffrey Scott DuPont, Robert Richard Dykstra, Robert Lee Eagan, Eddie Joseph Eckart, Jarvey Eugene Felty, Jr., Kevin John Fontenot, Jeffrey William Green, Shane Kipley Kirk, Gary Paul Lutz, Tony Lee Sander, Thomas Hugh Williams, George Chester Zima
  • Patent number: 6468487
    Abstract: In the presence of an imide compound (e.g., N-hydroxyphthalimide) shown by the following formula (1): wherein R1 and R2 represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group and a cycloalkyl group, and R1 and R2 may bond together to form a double bond, or an aromatic or non-aromatic ring, and Y is an O or OH, and n denotes 1 to 3; a substrate is allowed to contact with at least one reactant selected from (i) a nitrogen oxide and (ii) a mixture of carbon monoxide and oxygen to be introduced with at least one functional group selected from a nitro group and a carboxyl group. The nitrogen oxide includes, for example, a compound represented by the formula NxOy (e.g., N2O3, NO2). The substrate includes, for example, a compound having a methine carbon atom (e.g., adamantane), a compound having a methyl group or a methylene group at an adjacent moiety of an aromatic ring.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: October 22, 2002
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano, Satoshi Sakaguchi
  • Patent number: 6448442
    Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents of formula I wherein n is 0 or 1, and where n is 1 each C6R5 moiety may be the same or different; X denotes a bond or a group providing a 1 to 7 atom chain linking two C6R5 moieties or, where n is 0, X denotes a group R; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M1, two or three non-adjacent R groups in each C6R5 moiety being iodine and at least one R group in each C6R5 moiety being an M or M1 moiety; each M which may be the same or different, is a non-ionic hydrophilic moiety; and each M1 independently represents a —CHOHCON(R1)2 group wherein each R1, which may be the same or different, is a hydrogen atom, an OH group or a C1-6 alkoxy or optionally hydroxylated C1-5 alkyl group; at least one R group in the molecule being an M1 moiety; and isomers thereof.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: September 10, 2002
    Assignee: Amersham Health AS
    Inventors: Torsten Almen, Fredrik Ek
  • Patent number: 6379590
    Abstract: A new method for producing unsymmetrically substituted fluorenyl compounds, one step of which is the preparation of 2,7-disubstituted fluoren-9-one derivatives via the nucleophilic substitution of a compound of the formula D wherein A′ is selected from the group consisting of —Br, —Cl, —F, —NO2, and —CN; A is selected from the group consisting of —NO2, —CN, —CO2R, —C(O)R, —SO2R, —SO2RF, —C(CN)═C(CN)2 and —CH═C(CN)2; RF is —CpF2p+1, p=from about 0 to about 10; R is an straight, branched or cyclic aliphatic alkyl group having about 1 to 10 carbon atoms, or an aromatic group such as phenyl or naphthyl; and is a carbonyl or a protected carbonyl such as a ketal or thio-ketal such as wherein R′ is —CrH2r+1; R″ is —(CH2)r—; and r is independently 2 or 3, with a nucleophilic reagent in the presence of an aprotic solvent
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: April 30, 2002
    Assignee: AlliedSignal Inc.
    Inventors: Chengjiu Wu, Jianhui Shan
  • Patent number: 6355673
    Abstract: Compounds of formula (I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: March 12, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase, Bernhard Neises, Günter Billen
  • Patent number: 6337420
    Abstract: An electroclinic device having two spaced cell walls each bearing electrode structures and treated on at least one facing surface with an alignment layer, a layer of a smectic liquid crystal material enclosed between the cell walls, where the liquid crystal material contains one or more of the compounds described by formula I as defined in the specification.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: January 8, 2002
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland Defence Evaluation Research Agency
    Inventors: Andrew John Slaney, Damien Gerard McDonnell, Amarjit Kaur Samra, Maurice Stanley, Victoria Minter, John William Goodby, Michael Hird, Simon John Cross, Chu Chuan Dong
  • Patent number: 6310243
    Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula C6R6 wherein three non-adjacent R groups are iodine and the remaining R groups are non-ionic, hydrophilic moieties, said compound being water soluble at 20° C. to a concentration of at least 350 mgl/ml and which in aqueous solution at 20° C. at a concentration of 350 mgl/ml has a viscosity no greater than 13.8 mPas.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: October 30, 2001
    Assignee: Nycomed Imaging AS
    Inventors: Torsten Almen, Sven Andersson, Lars-Goran Wistrand, Klaes Golman, Oyvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, Hakan Wikstrom, Tomas Klingstedt, Ib Luenbach, Arne Berg, Harald Dugstad
  • Patent number: 6235851
    Abstract: A compound shown by the following formula: wherein each of R1a, R2a, R3a and R4a represents a substituent selected from a non-reactive atom, a non-reactive group, a hydroxyl group and an amino group, and at least two members selected from R1a, R2a, R3a and R4a are a hydroxyl group, a carboxyl group or an amino group; is subjected to an esterification reaction or an amidation reaction with a polymerizable unsaturated compound (e.g., an alcohol, a carboxylic acid, an amine) in the presence of a catalyst comprising an element selected from the Group 3 elements, such as a samarium compound, to obtain a polymerizable adamantane derivative having at least one polymerizable unsaturated group in high yield.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: May 22, 2001
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Yasutaka Ishii, Tatsuya Nakano, Naruhisa Hirai
  • Patent number: 5993780
    Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: November 30, 1999
    Assignee: Nycomed Imaging AS
    Inventors: Torsten Almen, Sven Goran Andersson, Lars-Goran Wistrand, Klaes Golman, .O slashed.yvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, H.ang.kan Wikstrom, Tomas Klingstedt, Ib Leunbach, Arne Berg, Harald Dugstad
  • Patent number: 5882628
    Abstract: The invention provides low viscosity iodinated aryl compounds, useful as X-ray contrast agents, of formula I ##STR1## (wherein n is 0 or 1, and where n is 1 each C.sub.6 R.sub.5 moeity may be the same or different; each group R is a hydrogen atom, an iodine atom or a hydrophilic moiety M or M.sub.1, two or three non-adjacent R groups in each C.sub.6 R.sub.5 moiety being iodine and at least one, and preferably two or three, R groups in each C.sub.6 R.sub.5 moiety being M or M.sub.1 moieties; X denotes a bond or a group providing a 1 to 7 atom chain linking two C.sub.6 R.sub.5 moieties or, where n is 0, X denotes a group R; each M independently is a non-ionic hydrophilic moiety; and each M.sub.1 independently represents a C.sub.1-4 alkyl group substituted by at least one hydroxyl group and optionally linked to the phenyl ring via a carbonyl, sulphone or sulphoxide group, at least one R group being an M.sub.1 moiety; with the proviso that where n is zero either at least one M.sub.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 16, 1999
    Assignee: Nycomed Imaging AS
    Inventors: Torsten Almen, Sven Andersson, Lars-Goran Wistrand, Klaes Golman, Oyvind Antonsen, Rune Fossheim, Unni Nordby Wiggen, Hakan Wikstrom, Tomas Klingstedt, Ib Luenbach, Arne Berg, Harald Dugstad
  • Patent number: 5637614
    Abstract: 6,7-disubstituted-2-aminotetralines of general formula (1) ##STR1## and their pharmacologically acceptable salts, wherein X and Y, identical or different are selected from the group consisting of methoxy, acetoxy and fluoro; and R and R.sub.1, identical or different, are selected from the group consisting of hydrogen, ethyl, propyl, cyclopropylmethyl, 2-hydroxy-2-phenylethyl, 2-hydroxy-2-(4-methylphenyl)ethyl and 2-hydroxy-3-(4-methoxyphenoxy)propyl are endowed with immunomodulator activity.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: June 10, 1997
    Assignee: Sigma Tau
    Inventors: Piero Foresta, Mauro Marzi, Maria O. Tinti
  • Patent number: 5494605
    Abstract: The p-terphenyl derivatives of the formula shown below are useful in preparing practical ferroelectric liquid crystalline compositions. The derivatives exhibit excellent chemical stability and display the chiral smectic C or smectic C phase over a wide temperature range. ##STR1## wherein each of R.sub.1 and R.sub.2 is a straight or branched chain alkyl group having 1-18 carbon atoms; each of Y and Z is a single bond, O, COO or OCO; and any two of X.sub.1, X.sub.2, and X.sub.3 are fluorine atoms and the remainder is a hydrogen atom.
    Type: Grant
    Filed: November 24, 1993
    Date of Patent: February 27, 1996
    Assignee: Kanto Kagaku Kabushiki Kaisha
    Inventors: Makoto Kurihara, Hiromi Inoue, Atsushi Sugiura, Kenji Suzuki, Tsunenori Fujii
  • Patent number: 5488137
    Abstract: An electrophotographic photoconductor is composed of a substrate and a photoconductive layer formed thereon. The photoconductive layer is composed of a polymer including an acrylic acid ester moiety of formula (I) as repeat unit: ##STR1## wherein R.sup.1 represents hydrogen or a methyl group; R.sup.2, R.sup.3, and R.sup.4 each represent an alkyl group having 1 to 4 carbon atoms, a benzyl group, a phenyl group, a phenoxyl group, chlorine or bromine; n is an integer of 1 to 4; m is 0 or 1; and k is 0 or 1.The polymer and the monomer from which the polymer is prepared are synthesized.
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: January 30, 1996
    Assignee: Ricoh Company, Ltd.
    Inventors: Hiroshi Tamura, Toshio Fukagai, Naoshi Mishima, Masaomi Sasaki
  • Patent number: 5447659
    Abstract: Disclosed are novel active benzene derivatives represented by the general formula (I): ##STR1## (wherein X represents --CCO--, --OCO--, --CH.sub.2 C-- or --OCH.sub.2 --; A represents a hydrogen atom, a halogen atom or an alkyl or alkoxyl group having 1 to 20 carbon atoms; R represents an alkyl group having 1 to 20 carbon atoms; l and m each represents a number of 1 or 2, n represents a number of 0 or 1, but when n is 0 the sum of l and m is 3 or less; and * indicates asymmetric carbon atom), a process for producing the same, liquid-crystalline substances containing said derivatives as active ingredient, and optical switching elements utilizing the liquid crystal compositions containing said liquid-crystalline substances.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: September 5, 1995
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takayuki Higashii, Masayoshi Minai
  • Patent number: 5434295
    Abstract: The present invention provides certain novel 4-phenylpinene derivatives, and teaches how to use said novel derivatives and related compounds in pharmaceutical compositions that have utility in treating various pathological conditions associated with damage to the central nervous system. The active ingredient of the pharmaceutical compositions according to the present invention is a compound of the formula: ##STR1## wherein A - - - B designates an optional double bond, R.sub.1 designates a variety of organic moieties, G designates alkyl, halogen, or various oxy groups, and R.sub.3 designates various alkyl groups, ether groups, or combinations thereof.
    Type: Grant
    Filed: February 7, 1994
    Date of Patent: July 18, 1995
    Assignees: Yissum Research Development Company, Pharmos Corp.
    Inventors: Raphael Mechoulam, Aviva Breuer, Anat Biegon
  • Patent number: 5397504
    Abstract: A new biphenyl compound which is chemically stable and possesses practically excellent properties as a component for preparing ferroelectric smetic liquid crystalline compositions as well as a new liquid crystalline composition containing this compound.
    Type: Grant
    Filed: January 10, 1994
    Date of Patent: March 14, 1995
    Assignee: Kanto Kagaku Kabushiki Kaisha
    Inventors: Kazuhiko Tsuchiya, Kenji Suzuki, Atsushi Sugiura, Tsunenori Fujii
  • Patent number: 5382380
    Abstract: New p-terphenyl derivatives useful as components for preparing practical ferroelectric liquid crystalline compositions and excellent in chemical stability, as well as liquid crystalline compositions containing at least one of the p-terphenyl derivatives.
    Type: Grant
    Filed: June 1, 1992
    Date of Patent: January 17, 1995
    Assignee: Kanto Kagaku Kabushiki Kaisha
    Inventors: Makoto Kurihara, Hiromi Inoue, Atsushi Sugiura, Kenji Suzuki, Tsunenori Fujii
  • Patent number: 5354511
    Abstract: Compounds having non-linear optical activity of the general formula ##STR1## wherein D and A are electron donor and acceptor groups, respectively, R.sup.1 and R.sup.2 are aromatic bridging groups, X and Y are preferably groups capable of partaking in polymerization reactions are suitable for use in polymer-based light modulator devices.
    Type: Grant
    Filed: November 27, 1992
    Date of Patent: October 11, 1994
    Assignee: AlliedSignal Inc.
    Inventors: Chengjiu Wu, Jianhui Shan, Ajay Nahata
  • Patent number: 5347041
    Abstract: Monomers containing two diacetylene segments each of which is connected on one end through a spacer segment to a central mesogen segment, and on the other end to an additional spacer segment, are topochemically polymerized in a molecularly ordered phase to produce homogeneous molecular composites. A preferred monomer embodiment comprises a compound of the formulaH--(CH.sub.2).sub.m --C.tbd.C--C.tbd.C--(CH.sub.2).sub.n --CO--O--R.sub.1 --O--CO--(CH.sub.2).sub.n --C.tbd.C--C.tbd.C--(CH.sub.2).sub.m Hwhere m and n are the number of repeating units, and R.sub.1 is a biphenylene mesogen.
    Type: Grant
    Filed: June 16, 1993
    Date of Patent: September 13, 1994
    Assignee: Edison Polymer Innovation Corporation
    Inventor: Jerome B. Lando
  • Patent number: 5338484
    Abstract: Disclosed are novel active benzene derivatives represented by the general formula (I): ##STR1## (wherein X represents --COO--, --OCO--, --CH.sub.2 O-- or --OCH.sub.2 --; A represents a hydrogen atom, a halogen atom or an alkyl or alkoxyl group having 1 to 20 carbon atoms: R represents an alkyl group having 1 to 20 carbon atoms; l and m each represents a number of 1 or 2, n represents a number of 0 or 1, but when n is 0 the sum of l and m is 3 or less; and * indicates asymmetric carbon atom), a process for producing the same, liquid-crystalline substances containing said derivatives as active ingredient, and optical switching elements utilizing the liquid crystal compositions containing said liquid-crystalline substances.
    Type: Grant
    Filed: October 18, 1993
    Date of Patent: August 16, 1994
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Takayuki Higashii, Masayoshi Minai
  • Patent number: 5334766
    Abstract: A process for the resolution of racemic diphosphine oxides into the optically active antipodes by reacting the racemate with a resolving agent comprising using a carbamate or thiocarbamate of an optically active .alpha.-hydroxycarboxylic acid or .alpha.-aminocarboxylic acid as the resolving agent.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: August 2, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marco Cereghetti, Alain Rageot
  • Patent number: 5328643
    Abstract: The invention relates to optically active compounds represented by the general formula I ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, Q.sub.1, Q.sub.2, Q.sub.3, and M are defined as in the specification, methods and intermediates for their preparation, liquid crystal compositions comprising at least one optically active compound of formula I and their use in electrooptical display, switching and modulation devices.
    Type: Grant
    Filed: February 26, 1992
    Date of Patent: July 12, 1994
    Assignees: Takeda Chemical Industries, Ltd., Hitachi, Ltd.
    Inventors: Yuka Sudo, Katsumi Kondo, Teruo Kitamura, Koichi Matsumura, Mitsuru Kawada, Yoshihiro Sugihara
  • Patent number: 5312975
    Abstract: A process for the preparation of 5-(2,4-difluorophenyl)-salicylic acid comprising the reaction of an organometallic derivative with a suitable substituted benzene in the presence of a transition-metal based catalyst is described.
    Type: Grant
    Filed: December 27, 1991
    Date of Patent: May 17, 1994
    Assignee: Zambon Group S.p.A.
    Inventors: Claudio Giordano, Laura Coppi, Francesco Minisci
  • Patent number: 5242619
    Abstract: Optically active compounds of the formula ##STR1## wherein rings A, B and C each independently are unsubstituted or each are 1,4-phenylene substituted with at least one of halogen-, cyano-, methyl- or methoxy in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen; R.sup.1 is a radical of an optically active terpene alcohol after cleavage of the hydroxy group or a group --(CH.sub.2).sub.m --C*HX.sup.1 --R.sup.3 ; R.sup.2 is a radical of an optically active terpene alcohol after cleavage of the hydroxy group or a group --(CH.sub.2).sub.n --C*HX.sup.2 --R.sup.4 ; m and n each independently stand for the number O or 1: C* denotes a chiral carbon atom; X.sup.1 and X.sup.2 each independently are fluorine, chlorine, cyano, methyl or methoxy; R.sup.3 and R.sup.4 each independently denote a group R, phenyl or phenyl substituted with R, with the proviso that R.sup.3 is different from X.sup.1 and R.sup.4 is different from X.sup.
    Type: Grant
    Filed: May 7, 1992
    Date of Patent: September 7, 1993
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Nina I. Chernova, Alexander V. Ivashchenko, Marina V. Loseva, Olga S. Petrashevich, Evgeniy P. Pozhidaev, Arnold Z. Rabinovich, Martin Schadt
  • Patent number: 5238602
    Abstract: Compounds of the formula ##STR1## wherein n stands for the number 0 or 1; the rings A.sup.1, A.sup.2 and A.sup.3 represent 1,4-phenylene, 2-fluoro-1,4-phenylene or trans-1,4-cyclohexylene or one of these rings also represents a 2,5-disubstituted pyrimidine ring or a trans-2,5-disubstituted m-dioxane ring; X.sup.1 represents a single covalent bond, --COO--, --OOC--, --CH.sub.2 CH.sub.2 --, p--C.sub.6 H.sub.4 --, --CH.sub.2 CH.sub.2 --p-- C.sub.6 H.sub.4 --, --CH.sub.2 CH.sub.2 --p--C.sub.6 H.sub.4 --CH.sub.2 CH.sub.2 -- or, insofar as the rings A.sup.1 and A.sup.2 represent 1,4-phenylene, also --NON--; R.sup.2 represents 1E-alkenyl, 2Z-alkenyl, 3E-alkenyl, 4-alkenyl or alkenyloxy, with the proviso that the oxygen atom in alkenyloxy is linked with a saturated carbon atom; and R.sup.1 signifies 1E-alkenyl, 2Z-alkenyl, 3E-alkenyl, 4-alkenyl or, insofar as R.sup.2 represents alkenyloxy, also alkyl, their manufacture, as well as liquid crystalline mixtures and the use for electro-optical purposes.
    Type: Grant
    Filed: May 26, 1987
    Date of Patent: August 24, 1993
    Assignee: Hoffmann La Roche Inc.
    Inventors: Martin Petrzilka, Martin Schadt
  • Patent number: 5235068
    Abstract: Acylaromatic compounds ##STR1## (Q: aromatic compound residue; R: straight, branched or cyclic aliphatic group, aromatic group or araliphatic group) are prepared in high yield by a reaction, in the presence of a boron trifluoride complex catalyst, of an aromatic compound with ##STR2## (X: H, Cl, Br; Y: Cl, Br) or with RCOOH in the presence of (XYCHCO).sub.2 O.
    Type: Grant
    Filed: July 21, 1992
    Date of Patent: August 10, 1993
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Masayoshi Minai, Michitada Kondo, Yuji Ueda, Seiichi Kai, Takayuki Higashii
  • Patent number: 5210279
    Abstract: A continuous process for the production of diacetate derivatives of aromatic compounds, comprising feeding at any convenient temperature an oxygen-containing gas and feedstock comprising a diisopropyl ring substituted aromatic compound and the recycled monoisopropyl-monoacetate derivative thereof, to an oxidizer operated, for example, at from about 10.degree. C. to about 150.degree. C. and oxygen partial pressures of from about 0.05 to 10 atmospheres to form an oxidizer product comprising the mono- and dihydroperoxides of the feedstock, feeding the oxidizer product to a rearrangement-esterification zone containing acetic anhydride at from about 0.degree. C. to 150.degree. C. to form an ester product comprising the diacetate and monoisopropyl-monoacetate derivatives of the feedstock, distilling the ester product to separate the diacetate and monoisopropyl-monoacetate derivatives, and recycling the monoisopropyl-monoacetate derivative back to the oxidizer.
    Type: Grant
    Filed: July 12, 1990
    Date of Patent: May 11, 1993
    Assignee: Eastman Kodak Company
    Inventors: Dale E. Van Sickle, Brad W. Overturf
  • Patent number: 5208263
    Abstract: Disclosed are novel classes of anti-androgen including dihydrophenanthrene derivatives, their method of synthesis and their use in treating disorders associated with excessive androgenic activities.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: May 4, 1993
    Assignee: Arch Development Corporation
    Inventors: Shutsung Liao, John Pataki, Ronald G. Harvey
  • Patent number: 5167863
    Abstract: There are disclosed an optically active compound represented by the general formula: ##STR1## wherein n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, Q.sub.1, Q.sub.2, Q.sub.3, and M are defined as in the detailed explanation, and *-marked carbon atoms are each an asymmetric carbon atom; a liquid crystal composition comprising at least one optically active compound of said general formula and a liquid crystal optical modulator using the composition thereof.
    Type: Grant
    Filed: July 16, 1990
    Date of Patent: December 1, 1992
    Assignees: Hitachi, Ltd., Takeda Chemical Industries, Ltd.
    Inventors: Teruo Kitamura, Katsumi Kondo, Akio Mukoh, Koichi Matsumura, Mitsuru Kawada, Yoshihiro Sugihara
  • Patent number: 5064569
    Abstract: Optically active compounds of the formula I can be used as components of chiral titled smectic liquid crystal phases:R.sup.1 --C*HX--Q--A.sup.4 --Z.sup.1 --A.sup.2 --(Z.sup.2 --A.sup.3).sub.n --X'--Q'--C*HY'--R.sup.5 (I)whereinR.sup.1 --C*HX--Q-- and --X'--Q'--C*HY--R.sup.5 are identical optically active radicals selected from the group --O--C*HCH.sub.3 --COO--n--alkyl, --O--C*HCH.sub.3 --CH.sub.2 --O--n--alkyl, --OCO--C*HC1--CHCH.sub.3 --CH.sub.3, --OCO--C*HCl--C*HCH.sub.3 --C.sub.2 H.sub.5, --OCO--C*HCl--CH.sub.2 --CHCH.sub.3 --CH.sub.3, --OCO--C*HCl--C(CH.sub.3).sub.3, --COO--C*HCH.sub.3 -COO--n--alkyl, --O--CO--C*HCH.sub.3 --o--n--alkyl, --OCH.sub.2 --C*HCH.sub.3 --O--n--alkyl, --COO--C*HCH.sub.3 CH.sub.2 --O--n--allyl, --OC*HCH.sub.3 --CH.sub.2 --COO--n--alkyl, --COO--C*HCH.sub.3 --CH.sub.2 --COO--n--alkyl, --OCH.sub.2 --C*HCH.sub.3 --COO--n--alkyl or --COO--CH.sub.2 --C*HCH.sub.3 --COO--n--alkyl, alkyl is of 1--12 c atoms,and --A.sup.4 --Z.sup.1 --A.sup.2 --(Z.sup.2 --A.sup.3).sub.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: November 12, 1991
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Thomas Geelhaar, Andreas Wachtler, Bernhard Scheuble
  • Patent number: RE36849
    Abstract: Anisotropic compounds of the formula (1) specified in claim 1 are suitable, owing to their low .DELTA..epsilon./.epsilon..perp. values for liquid crystal displays which have high information densities of for examples up to 10.sup.6 image dots and accordingly need to be highly multiplexible; compared with known compounds they offer improved application properties and are relatively simple to synthesize.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: September 5, 2000
    Assignee: Merck Patent GmbH
    Inventors: Hans P. Schad, Stephen M. Kelly, Eike Poetsch, Reinhard Hittich, Georg Weber