Acyclic Acid Moiety Patents (Class 560/129)
  • Patent number: 10611718
    Abstract: There are provided methods of efficiently producing compounds that are, for example, sex pheromones of San Jose Scale. For example, there is provided a method for producing a 7-methyl-3-methylene-7-octenyl carboxylate compound (4), the method including the steps of: hydrolyzing a 7-methyl-3-methylene-7-octenal acetal compound (1) to obtain 7-methyl-3-methylene-7-octenal (2); reducing the 7-methyl-3-methylene-7-octenal (2) to obtain 7-methyl-3-methylene-7-octenol (3); and esterifying the 7-methyl-3-methylene-7-octenol (3) to obtain a 7-methyl-3-methylene-7-octenyl carboxylate compound (4).
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: April 7, 2020
    Inventors: Takeshi Kinsho, Akihiro Baba, Yusuke Nagae, Tomohiro Watanabe
  • Patent number: 10323197
    Abstract: There is described a process for producing biodiesel and related products from mixtures. There is also described a process for producing precursors and feedstock materials for producing biodiesel and related products. The processes use esterification and trans-esterification, separation and purification. Other process steps such as acidification and distillation can also be used.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: June 18, 2019
    Assignee: ARGENT ENERGY (UK) LIMITED
    Inventor: Michael Scott
  • Patent number: 9738575
    Abstract: An apparatus for producing ethylene includes: a reactor; a first separation column, connected to the reactor; a second separation column, the upper part of the second separation column being connected to the bottom of the first separation column, and the top of the second separation column being connected to the lower part of the first separation column; a first condenser, an inlet of the first condenser being connected to the top of the first separation column, and an outlet of the first condenser being connected to the upper part of the first separation column; and a third separation column, used for receiving a second part of a first condensate from the condenser and separating the received part. A method for producing ethylene using the aforementioned apparatus is also described.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: August 22, 2017
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, SHANGHAI RESEARCH INSTITUTE OF PETROCHEMICAL TECHNOLOGY SINOPEC
    Inventors: Baixiang Shao, Wei Shen, Zhi He, Yiming Wu
  • Patent number: 9663437
    Abstract: A process for producing acetic acid comprising the steps of reacting carbon monoxide and at least one of methanol and a methanol derivative in a first reactor under conditions effective to produce a crude acetic acid product; separating the crude acetic acid product into at least one derivative stream, at least one of the at least one derivative stream comprising residual carbon monoxide; and reacting at least a portion of the residual carbon monoxide with at least one of methanol and a methanol derivative over a metal catalyst in a second reactor to produce additional acetic acid. Preferably the second reactor is a homogeneous reactor and a reactor carbon monoxide partial pressure is less than 1.05 MPa.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: May 30, 2017
    Assignee: CELANESE INTERNATIONAL CORPORATION
    Inventors: G. Paull Torrence, Brian W. Hokkanen, Ronald David Shaver
  • Patent number: 9409832
    Abstract: A catalytic process for dehydration of an aliphatic C2-C6 alcohol to its corresponding olefin is disclosed. The process continuously flows through a reaction zone a liquid phase containing an aliphatic C2-C6 alcohol to contact a non-volatile acid catalyst at a reaction temperature and pressure to at least partially convert the aliphatic C2-C6 alcohol in the liquid phase to its corresponding olefin. The reaction pressure is greater than atmospheric pressure and the reaction temperature is above the boiling point of the olefin at reaction pressure, but below the critical temperature of the alcohol, and the olefin product is substantially in the gaseous phase. After the contacting step, the olefin containing gaseous phase is separated from the liquid phase. The invention also relates to catalytic processes such as a hydrolysis of an olefin to an alcohol, an esterification, a transesterification, a polymerization, an aldol condensation or an ester hydrolysis.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: August 9, 2016
    Assignee: SIGNA CHEMISTRY, INC.
    Inventors: Michael Lefenfeld, Robert Hoch
  • Patent number: 9399724
    Abstract: Pressure-sensitive adhesive compositions and articles containing the pressure-sensitive adhesives are provided. The pressure-sensitive adhesives contain an (meth)acrylic-based elastomeric material prepared from (2-isopropyl-5-methyl)hexyl (meth)acrylate.
    Type: Grant
    Filed: September 12, 2012
    Date of Patent: July 26, 2016
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Kevin M. Lewandowski, Jason D. Clapper, Terence D. Spawn
  • Patent number: 9388118
    Abstract: A continuous process for preparing (meth)acrylates of C10-alcohol mixtures by reaction of glacial (meth)acrylic acid with an isomer mixture of C10-alcohols composed of 2-propylheptanol as the main isomer and at least one of the C10-alcohols 2-propyl-4-methylhexanol, 2-propyl-5-methylhexanol, 2-isopropylheptanol, 2-isopropyl-4-methylhexanol, 2-isopropyl-5-methylhexanol and/or 2-propyl-4,4-dimethylpentanol, and the use of a diester of dicarboxylic acids which have been esterified with N-oxyl-containing compounds as polymerization inhibitors in such a process.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: July 12, 2016
    Assignee: BASF SE
    Inventors: Ulrich Jaeger, Volker Schliephake, Ortmund Lang, Jochen Petzoldt, Tobias Johannes Korn, Virginie Bette, Claus Hechler
  • Patent number: 9382182
    Abstract: The present invention relates to a process for preparing at least one diacid compound, comprising a step of hydrolysis reaction of at least one imide compound, performed in the absence of catalyst.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: July 5, 2016
    Assignee: RHODIA OPERATIONS
    Inventors: Roland Jacquot, Bouchra Rhers
  • Patent number: 9340658
    Abstract: Disclosed is a plasticizer comprising xylylene glycol di-2-ethylhexanoate. The plasticizer can comprise xylylene glycol di-2ethylhexanoate and a second plasticizer. Also disclosed is a plastisol comprising a PVC resin dispersed in the liquid phase and a plasticizer comprising xylylene glycol di-2-ethylhexanoate and a second plasticizer. Additionally disclosed, an article can comprise the fused plastisol.
    Type: Grant
    Filed: July 24, 2014
    Date of Patent: May 17, 2016
    Assignee: Eastman Chemical Company
    Inventors: Venkata Bharat Ram Boppana, Joseph Alexander DeLoach, Christopher Harlan Burk
  • Patent number: 9040741
    Abstract: A catalytic process for dehydration of an aliphatic C2-C6 alcohol to its corresponding olefin is disclosed. The process continuously flows through a reaction zone a liquid phase containing an aliphatic C2-C6 alcohol to contact a non-volatile acid catalyst at a reaction temperature and pressure to at least partially convert the aliphatic C2-C6 alcohol in the liquid phase to its corresponding olefin. The reaction pressure is greater than atmospheric pressure and the reaction temperature is above the boiling point of the olefin at reaction pressure, but below the critical temperature of the alcohol, and the olefin product is substantially in the gaseous phase. After the contacting step, the olefin containing gaseous phase is separated from the liquid phase. The invention also relates to catalytic processes such as a hydrolysis of an olefin to an alcohol, an esterification, a transesterification, a polymerization, an aldol condensation or an ester hydrolysis.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: May 26, 2015
    Assignee: SIGNA CHEMISTRY, INC.
    Inventors: Michael Lefenfeld, Robert Hoch
  • Publication number: 20150141509
    Abstract: The present invention is directed to pharmaceutical compositions comprising compounds found in Harderian gland secretions, a method of treating dry eye in a human comprising ophthalmically administering an effective amount of a compound, e.g. a lipid compound, found in Harderian gland secretions, pharmaceutical compositions comprising said lipid compounds, as identified by characteristic chemical data and mass spectra of said lipid compounds, said lipid compound in essentially pure form, and an ophthalmic vehicle comprising a therapeutic agent and a compound present in the secretions of the Harderian gland, e.g. a lipid compound, found in the secretions of the Harderian gland, e.g. a rabbit Harderian gland.
    Type: Application
    Filed: October 24, 2014
    Publication date: May 21, 2015
    Inventors: Daniel M. Albert, Arthur S. Polans
  • Patent number: 9029613
    Abstract: Provided is an alicyclic alcohol compound which can be used as a raw material for a compound perfume, and which has excellent floral-green-like aromas which are crisp and fresh; also provided are a manufacturing method for the same, and a perfume composition which contains the alicyclic alcohol compound. An alicyclic alcohol compound having a specified structure represented by chemical formula (1) has excellent floral-green-like aromas which are crisp and fresh; and a method for manufacturing the alicyclic alcohol compound represented by chemical formula (1) by reacting, in the presence of hydrogen fluoride, 4-isopropyl-1-methylcyclohexene and carbon monoxide, isomerizing the resulting 4-isopropyl-1-methylcyclohexane carboxylic acid fluoride, thus making 2-methyl-2-(4-methylcyclohexyl)-propionyl fluoride, reacting with alcohol and acquiring a cyclohexane carbonyl compound, and then reducing the cyclohexane carbonyl compound.
    Type: Grant
    Filed: December 27, 2011
    Date of Patent: May 12, 2015
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Mitsuharu Kitamura, Yoshiharu Ataka, Kazuyuki Fukuda
  • Publication number: 20150119461
    Abstract: The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPAR?, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPAR? modulation such as diabetes.
    Type: Application
    Filed: January 9, 2015
    Publication date: April 30, 2015
    Inventors: Veera KONDA, Jan URBAN, Anuradha DESAI, Clinton J. DAHLBERG, Brian J. CARROLL
  • Publication number: 20150119597
    Abstract: Provided is a simple and efficient method for producing 2-isopropylidene-5-methyl-4-hexenyl butyrate. More specifically, provided is a method for producing 2-isopropylidene-5-methyl-4-hexenyl butyrate, the method including the steps of: isomerizing 2-isopropenyl-5-methyl-4-hexenoic acid ester (1) into 2-isopropylidene-5-methyl-4-hexenoic acid ester (2), reducing thus formed 2-isopropylidene-5-methyl-4-hexenoic acid ester (2) into 2-isopropylidene-5-methyl-4-hexenol (3), and butyrylating thus formed 2-isopropylidene-5-methyl-4-hexenol (3) into 2-isopropylidene-5-methyl-4-hexenyl butyrate (4), wherein R represents a C1-10 hydrocarbon group.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Inventors: Takeshi KINSHO, Naoki ISHIBASHI, Miyoshi YAMASHITA, Yuki MIYAKE, Akihiro BABA, Yusuke NAGAE
  • Patent number: 9006219
    Abstract: The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: April 14, 2015
    Assignee: Nektar Therapeutics
    Inventors: Timothy A. Riley, Lin Cheng
  • Publication number: 20150099896
    Abstract: A continuous process for the production of an alkyl ester product is described. The process includes the steps of carbonylating ethylene with carbon monoxide in the presence of C1-6 alkanol co-reactant to form the alkyl ester product. The carbonylation takes place in the presence of a catalyst system that includes (a) a bidentate ligand, (b) a catalytic metal selected from a group 8, 9 or 10 metal or a compound thereof, and (c) a sulphonic acid capable of forming an acid alkyl ester with the C1-6 alkanol. The process includes the step of separating the alkyl ester product from a carbonylated crude product stream by treatment effective to vaporizing the alkyl ester product in a single stage flash distillation column and providing a purified alkyl ester product stream separated from the bidentate ligand and catalytic metal.
    Type: Application
    Filed: December 20, 2012
    Publication date: April 9, 2015
    Applicant: Lucite International UK Limited
    Inventors: Neil Tindale, Graham Ronald Eastham
  • Publication number: 20150080599
    Abstract: Alkyl esters (butyl, hexyl, or other) of full composition palm fatty acids, palm fatty acid distillates (PFAD), and palm kernel fatty acid distillates (PKFAD) can be used to generate polyurethane and lubricant products. The alkyl esters of the present invention can be produced via ozonolysis. The improved method for producing alkyl esters includes reacting at least one substance having at least one carbon-to-carbon double bond with ozone in the presence of least one monoalcohol that azeotropes with water. In particular, the method may comprise reacting with at least one first mole of ozone and at least one second mole of ozone, and further comprises refluxing before addition of the second mole of ozone.
    Type: Application
    Filed: February 28, 2013
    Publication date: March 19, 2015
    Applicant: PETROLIAM NASIONAL BERHAD
    Inventors: Daniel B. Garbark, Herman Paul Benecke
  • Patent number: 8957242
    Abstract: Methods, processes, apparatus, equipment and systems are disclosed for converting carboxylic acids into esters by esterification with alcohol and a dual catalyst. The method combines a homogenous and heterogeneous catalyst in one or more reactors to increase the conversion of carboxylic acids compared to using a homogenous and/or heterogeneous catalyst independently. The invention converts free fatty acids into esters by esterification with alcohol and a dual catalyst such that the reaction mixture contains sufficiently low free fatty acids and the amount of free fatty acids in the product stream leaving the process remains stable over time.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 17, 2015
    Assignee: Renewable Energy Group, Inc.
    Inventors: David A. Slade, Cody J. Ellens, Jared N. Brown, Anthony J. S. Pollard, Bradley Neil Albin
  • Publication number: 20150038582
    Abstract: Therapeutic regimes for improving visual function in a subject having a deficiency in endogenously produced 11-cis retinal comprising administering the synthetic retinal derivative as a divided dose over 2-7 days then providing a resting period of 7-28 days after which the second dose of the synthetic retinal derivative is administered. Preferred synthetic retinal derivatives are 9- or 11-cis-retinyl esters. Disorders associated with deficiency in endogenously produced 11-cis retinal include retinitis pigmentosa and Leber congenital amaurosis.
    Type: Application
    Filed: March 1, 2013
    Publication date: February 5, 2015
    Applicant: QLT INC.
    Inventor: Suzanne Cadden
  • Publication number: 20150030638
    Abstract: The present invention broadly relates to the use of certain ingenol derivatives as HIV reactivators of latent HIV virus in viral reservoirs. In another aspect, the present invention relates to an association comprising such ingenol derivatives and antiretroviral agents substantially active against actively replicating virus.
    Type: Application
    Filed: March 1, 2013
    Publication date: January 29, 2015
    Applicant: AMAZÔNIA FITOMEDICAMENTOS LTDA.
    Inventors: Luiz Francisco Pianowski, Amilcar Tanuri
  • Patent number: 8940921
    Abstract: [Problem] There are provided a method for production of a fatty acid alkyl ester and a system therefor, in which a high yield of the fatty acid alkyl ester is achieved even without using any special equipment and separation of a fatty acid alkyl ester phase from a glycerin phase can be carried out within an extremely short period of time. [Means to solve] The method for producing a fatty acid alkyl ester of the present invention comprises subjecting a starting oil to an ester exchange reaction with a lower alkyl alcohol in the presence of a catalyst to generate the fatty acid alkyl ester, wherein the ester exchange reaction step is carried out in a homogeneous phase system by adding an organic solvent selected from acetone, isopropanol and a mixture thereof to a reaction system.
    Type: Grant
    Filed: March 14, 2010
    Date of Patent: January 27, 2015
    Assignee: Osaka Prefecture University Public Corporation
    Inventors: Yasuaki Maeda, Hiroshi Bandow, Norimichi Takenaka, Yasuhiro Sadanaga, Kenji Okitsu
  • Publication number: 20150011791
    Abstract: The present invention is related to a new metal powder catalytic system (catalyst) comprising a Fe-alloy as a carrier, its production and its use in hydrogenation processes.
    Type: Application
    Filed: February 22, 2013
    Publication date: January 8, 2015
    Inventors: Werner Bonrath, Axel Buss
  • Publication number: 20140377706
    Abstract: An aqueous solution containing 0.1-20 wt % of a substituted choline or thiocholine hydroxide is a useful developer for photosensitive resist materials. A resist pattern is formed by applying a chemically amplified positive resist composition onto a substrate to form a resist film, exposing the resist film to high-energy radiation, and developing the exposed resist film in an ammonium hydroxide-containing aqueous solution.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 25, 2014
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Masaki Ohashi
  • Publication number: 20140371313
    Abstract: The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. The invention also provides methods of preparing the provided CHD compounds.
    Type: Application
    Filed: May 12, 2014
    Publication date: December 18, 2014
    Inventors: Donald Kirsch, Radhia Benmohamed, Anthony C. Arvanites, Richard I. Morimoto, Wei Zhang, Richard B. Silverman
  • Publication number: 20140364595
    Abstract: The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m?-X]p-L; (iii) AFA-[X-(L)n?]q; or (iv) (AFA)m?-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m? is 1 to 10; p is 1 to 10; n? is 1 to 10; and q is 1 to 10, provided that q? and n are not both 1; and m? is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.
    Type: Application
    Filed: June 22, 2012
    Publication date: December 11, 2014
    Applicant: VYOME BIOSCIENCES
    Inventors: Abhijit S. Bapat, Gauthami Mahesh, Rajesh S. Gokhale, Sayali S. Shah, Shiladitya Sengupta, Sudhanand Prasad, Sumana Ghosh, Suresh R. Chawrai, Nidhi Arora, D. Sreedhar Reddy, Malika Mishra, Kirti Bajaj
  • Publication number: 20140357881
    Abstract: Process for coproduction of a vinyl ester of the formula R—C(O)O—CH?CH by transvinylation reaction of a carboxylic acid of the formula R—C(O)OH with a transvinylating reagent of the formula R1—C(O)O CH?CH2, characterized in that (a) the transvinylation reaction is conducted continuously at a temperature of 90 to 160° C. and at a pressure of 0.
    Type: Application
    Filed: January 18, 2013
    Publication date: December 4, 2014
    Inventors: Leif Johnen, Heinz Strutz
  • Patent number: 8901169
    Abstract: In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: December 2, 2014
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Erik Fenster, Melissa Fleury, Adam D. Hughes
  • Patent number: 8901356
    Abstract: The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: December 2, 2014
    Assignee: Leo Laboratories Limited
    Inventors: Thomas Högberg, Gunnar Grue-Sørensen, Xifu Liang, Anne Marie Horneman, Anders Klarskov Petersen
  • Publication number: 20140350289
    Abstract: The present invention relates to new organic compounds, to their synthesis as well as to their use in organic synthesis, especially in processes forming intermediates (building blocks) for the synthesis of vitamin A or ?-carotene or other carotenoids.
    Type: Application
    Filed: June 14, 2012
    Publication date: November 27, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Thomas Netscher, Jan Schütz, Bettina Wüstenberg
  • Patent number: 8895040
    Abstract: The present invention relates to cosmetic and/or personal care formulations and/or compounds. In one embodiment, the present invention relates to ester compounds that can be used in various personal care formulations and/or compounds. In another embodiment, the present invention relates to branced ester compounds having a molecular weight of at least about 1,500 daltons that can be used in various personal care formulations and/or compounds.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: November 25, 2014
    Assignee: Lubrizol Advanced Materials, Inc.
    Inventors: Brian J. Vondruska, Peter Frank, Anchuu Wu
  • Patent number: 8894821
    Abstract: Disclosed is a dividing wall column for preparing high-purity 2-ethylhexyl-acrylate, and a method for distilling 2-ethylhexyl-acrylate. The dividing wall column provides an effect having two distillation columns through one distillation column, thereby having an effect of reducing energy compared to the conventional processing device in preparing high-purity 2-ethylhexyl-acrylate and an effect of reducing equipment costs of the device.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: November 25, 2014
    Assignee: LG Chem, Ltd.
    Inventors: Sung Kyu Lee, Joon Ho Shin, Jong Ku Lee, Sung Kyun Kim
  • Patent number: 8895765
    Abstract: A method for preparing fatty acid alkyl ester for bio-diesel fuel is disclosed wherein fatty acid, specifically fatty acid distillate reacts with alcohol. The method does not require the glycerin purification process, and has the superior conversion ratio of fatty acid. The method for preparing fatty acid alkyl ester for bio-diesel fuel comprises the step of carrying out a counter current type esterification reaction of fatty acid and alcohol in each tray of a counter current column reactor at a temperature of 200 to 350° C. and a pressure of 1 to 35 bar. Here the raw material of the fatty acid is fed to an upper part of the counter current column reactor and the alcohol is fed to a lower part of the counter current column reactor. The counter current column reactor has a number of trays which are installed horizontally to have a number of vertical compartments. Each of the number of trays has an opening part at one end thereof to communicate one compartment with an adjoining compartment.
    Type: Grant
    Filed: September 22, 2009
    Date of Patent: November 25, 2014
    Assignee: SK Chemicals Co., Ltd.
    Inventors: Soo-Hyun Kim, Hyun-Jun Cho, Chan-Woo Moon, Byoung-Kyung Ham, Jae-Bong Lim
  • Publication number: 20140343310
    Abstract: The present invention relates to a continuous, catalytic process for preparing a vinyl ester of the formula R—C(O)O—CH?CH2 by reaction of a carboxylic acid of the formula R—C(O)OH with a transvinylating reagent of the formula R1—C(O)O—CH?CH2, wherein the reaction is effected at a temperature of 90 to 160° C. and at a pressure of 0.5 to 15 MPa without withdrawal of a reactant in the presence of a transition metal catalyst containing at least one transition metal from the group of ruthenium, osmium, rhodium, iridium, palladium and platinum, and then the resulting reaction mixture is separated into its constituents.
    Type: Application
    Filed: January 18, 2013
    Publication date: November 20, 2014
    Inventors: Leif Johnen, Heinz Strutz, Kurt Schalapski, Norman Nowotny, Wolfgang Höfs, Sebastian Geisel
  • Publication number: 20140328938
    Abstract: Biodegradable pharmaceutical compositions comprising 1,3-propanediol and its esters are provided. The 1,3-propanediol and its esters in the pharmaceutical composition are biologically derived, and as such, the pharmaceutical compositions exhibit a low anthropogenic CO2 emission profile.
    Type: Application
    Filed: July 14, 2014
    Publication date: November 6, 2014
    Applicant: DuPont Tate & Lyle Bio Products Company, LLC
    Inventors: Robert Miller, Joseph Desalvo, Gyorgyi Fenyvesi, Melissa Joerger, Raja Hari Poladi, Ann Wehner
  • Patent number: 8877960
    Abstract: When sulfinating a carboxylic acid bromofluoroalkyl ester by using a sulfinating agent, an organic base is used, thereby obtaining a fluoroalkanesulfinic acid ammonium salt. This is oxidized to obtain a fluoroalkanesulfonic acid ammonium salt. This is used as the raw material and is converted to an onium salt or is converted to an onium salt by going through saponification and esterification, thereby obtaining a fluoroalkanesulfonic acid onium salt. This fluoroalkanesulfonic acid onium salt is useful as a photoacid generator used for chemically amplified resist materials, etc.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: November 4, 2014
    Assignee: Central Glass Company, Limited
    Inventors: Masashi Nagamori, Yuji Hagiwara, Takashi Masubuchi, Satoru Narizuka
  • Publication number: 20140323755
    Abstract: There is provided a method of producing biodiesel without drying and lipid component extraction steps in an alcohol-rich condition. Also, there is provided a method of effectively producing biodiesel without a catalyst under optimal conditions for transesterification. Production cost and time are reduced by reducing the number of processes, and biodiesel yield is increased.
    Type: Application
    Filed: May 3, 2013
    Publication date: October 30, 2014
    Inventors: Hee-Mock Oh, Hyun Joon La, Jae Yon Lee, Hee-Sik Kim, Chi-Yong Ahn
  • Patent number: 8871960
    Abstract: Methods to convert unsaturated fatty acids derived from biobased oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: October 28, 2014
    Assignee: Battelle Memorial Institute
    Inventors: Herman Paul Benecke, Daniel B. Garbark
  • Publication number: 20140315834
    Abstract: The present invention provides novel compounds and pharmaceutical compositions for the prevention and/or treatment of cancer and precancerous conditions thereof, for the treatment of pain and fever, for the treatment of skin disorders, and for treating and/or preventing inflammation-related diseases and/or cardiovascular diseases. The compounds of the invention also have analgesic properties and anti-platelet properties. The compounds of the invention may be provided to animals, including mammals and humans, by administering a suitable pharmaceutical dose in a suitable pharmaceutical dosage form. The compounds of the invention have improved efficacy and safety, including higher potency and/or fewer or less severe side effects, than conventional therapies. The compounds of the invention comprise a biologically active moiety or portion (A) that has, or is modified to have at least one carboxyl group.
    Type: Application
    Filed: September 23, 2013
    Publication date: October 23, 2014
    Applicant: Medicon Pharmaceuticals, Inc.
    Inventor: Basil RIGAS
  • Patent number: 8865922
    Abstract: A method of treating tall oil pitch, which comprises sterol esters of fatty acids. According to the present invention, the esters of sterols and fatty acids are broken down, in which case especially formic acid esters or acetic acid esters of sterols are formed instead. The free fatty acids and sterol esters generated are distilled or separated in another way. Use of the present invention increases the yield of fatty acids and also facilitates the separation of sterols from tall oil pitch.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: October 21, 2014
    Assignee: Forchem Oy
    Inventors: Esko Kiviranta, Juhani Saviainen, Mikko Rintola
  • Publication number: 20140309435
    Abstract: The invention provides a process for preparing esters from formates and olefinically unsaturated compounds with catalysts based on palladium compounds. In addition, the invention discloses a polyphasic reaction mixture and nonyl methyl ester mixtures prepared by the process according to the invention.
    Type: Application
    Filed: December 17, 2012
    Publication date: October 16, 2014
    Applicant: EVONIK INDUSTRIES AG
    Inventors: Robert Franke, Dieter Hess, Matthias Beller, Ralf Jackstell, Daniela Cozzula, Ivana Fleischer, Reiko Jennerjahn
  • Patent number: 8858761
    Abstract: Disclosed is a dividing wall column for preparing high-purity 2-ethylhexyl-acrylate, and a method for distilling 2-ethylhexyl-acrylate. The dividing wall column provides an effect having two distillation columns through one distillation column, thereby having an effect of reducing energy compared to the conventional processing device in preparing high-purity 2-ethylhexyl-acrylate and an effect of reducing equipment costs of the device.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: October 14, 2014
    Assignee: LG Chem, Ltd.
    Inventors: Sung Kyu Lee, Joon Ho Shin, Jong Ku Lee, Sung Kyun Kim
  • Publication number: 20140296241
    Abstract: The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment.
    Type: Application
    Filed: October 15, 2012
    Publication date: October 2, 2014
    Inventors: Irving W. Wainer, Ruin Moaddel, Michel Bernier, Carlos A. Zarate, Marc C. Torjman, Michael E. Goldberg, Mary J. Tanga
  • Publication number: 20140288175
    Abstract: A method for treating glycogen storage disease by administering an effective amount of a composition that includes ketogenic odd carbon fatty acids that ameliorate the symptoms of these diseases.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: Baylor Research Institute
    Inventor: Charles R. ROE
  • Publication number: 20140275612
    Abstract: Methods, processes, apparatus, equipment and systems are disclosed for converting carboxylic acids into esters by esterification with alcohol and a dual catalyst. The method combines a homogenous and heterogeneous catalyst in one or more reactors to increase the conversion of carboxylic acids compared to using a homogenous and/or heterogeneous catalyst independently. The invention converts free fatty acids into esters by esterification with alcohol and a dual catalyst such that the reaction mixture contains sufficiently low free fatty acids and the amount of free fatty acids in the product stream leaving the process remains stable over time.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Renewable Energy Group, Inc.
    Inventors: David A. Slade, Cody J. Ellens, Jared N. Brown, Anthony J.S. Pollard, Bradley Neil Albin
  • Publication number: 20140275380
    Abstract: The present invention relates to novel dispersants based on reaction products of two and one moles respectively of the branched ester alcohol or alkokylated ester alcohol with maleic anhydride that has been subjected to a further sulfonation reaction. The compounds are useful as dispersing and wetting agents. The invention further relates to the use of the dispersants of the invention to produce stable aqueous dispersions of high performance thermoplastic polymers.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Inventor: James T. Tanner
  • Publication number: 20140275245
    Abstract: Analgesic compounds for treatment of pain or fever, comprising a bicyclopentane moiety linked to an amine, combinations of the compounds with opioid analgesic drugs, and methods for treating pain or fever by administering the compounds.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 18, 2014
    Applicant: KALYRA PHARMACEUTICALS, INC.
    Inventor: Kevin Duane Bunker
  • Patent number: 8834857
    Abstract: A method for cleaning, benefiting, or deodorizing skin or hair utilizing a body wash, skin cleaner, soap, shampoo or deodorizer formulation containing a controlled release skin benefit or deodorizing salt, a hydrophilic moisturizing polymer and surfactants is described. The method imparts benefits or deodorizing agents to the skin or hair and maintains effective levels for an extended period.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: September 16, 2014
    Assignee: Nevada Naturals Inc.
    Inventors: Anthony E. Winston, Richard F. Stockel, Anthony Joseph Sawyer
  • Patent number: 8835495
    Abstract: The present invention relates to an association of active ingredients. More specifically: to an association of cyclobenzaprine and aceclofenac. Additionally, the present invention is also related to the use of aceclofenac and cyclobenzaprine, in association for the preparation of a medicine useful in the treatment of painful muscular diseases, as well as to a method of treatment of painful muscular diseases using an association of aceclofenac and cyclobenzaprine.
    Type: Grant
    Filed: June 6, 2007
    Date of Patent: September 16, 2014
    Assignee: Incrementha P, D & I Pesquisa, Desenvolvimento e Inovacao de Farmacos e Medicamentos Ltda
    Inventors: Dante Alario Júnior, Julio Cesar Gagliardi
  • Publication number: 20140243544
    Abstract: Methods of preparing carbamate prodrugs of amine-containing drugs are provided. Carbonates useful in the synthesis of the carbamate prodrugs are also provided.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: XENOPORT, INC.
    Inventors: Huan Wang, Peng Liu, Qunying Dai, Hao Yin, Stephen P. Raillard
  • Publication number: 20140235891
    Abstract: The invention relates to an application of organic framework porous solid acid.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 21, 2014
    Applicant: PetroChina Company Limited
    Inventors: Wenpeng Li, Fengshou Xiao, Haicheng Xiao, Fujian Liu, Yinghui Li, Xiangju Meng, Xianming Xu, Xiangmin Yu, Wei Zhang, Kezhong Xu, Guoquan Song, Haotian Pei, Fangwei Li, Qunying Zeng, Zhixiang Zhang, Yeman Li