Sulfur, Nitrogen, Halogen, Oxy, Or Aldehyde Or Ketone Group In Acid Moiety Patents (Class 560/145)
  • Patent number: 8748549
    Abstract: To provide a fluorinated compound having an RF group with at most 6 carbon atoms, whereby a fluorinated polymer having a highly durable water/oil repellency can be produced, and an environmental load is little, and a fluorinated polymer and a fluorinated copolymer having a highly durable water/oil repellency and presenting little environmental load, obtainable by polymerizing such a fluorinated compound. A fluorinated compound represented by the following formula (I) and its polymer: CH2?C(M)COO(CH2)nPhCOO(CH2)mCrF2r+1??(I) (in the formula (I), M is a hydrogen atom, a methyl group or a halogen atom, n is an integer of from 0 to 2, Ph is a phenylene group, m is an integer of from 1 to 4, and r is an integer of from 1 to 6).
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: June 10, 2014
    Assignee: Asahi Glass Company, Limited
    Inventor: Taiki Hoshino
  • Patent number: 8653131
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: February 18, 2014
    Assignees: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Guohan Yang, Ton That Hai, Bennett P. Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • Patent number: 8558024
    Abstract: To provide a fluorinated compound having an RF group with at most 6 carbon atoms, whereby a fluorinated polymer having a highly durable water/oil repellency can be produced, and an environmental load is little, and a fluorinated polymer having a highly durable water/oil repellency and presenting little environmental load, obtainable by polymerizing such a fluorinated compound. A fluorinated compound represented by the following formula (I) and its polymer: CH2?C(M)COO(CH2)nPhXPhZCrF2r+1??(I) (in the formula (I), M is a hydrogen atom, a methyl group or a halogen atom, n is an integer of from 0 to 2, Ph is a phenylene group, X is CH2O or OCH2, Z is a single bond, a C1-4 alkylene group containing an etheric oxygen atom, or COO(CH2)m (wherein m is an integer of from 1 to 4), and r is an integer of from 1 to 6).
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: October 15, 2013
    Assignee: Asahi Glass Company, Limited
    Inventor: Taiki Hoshino
  • Publication number: 20130190475
    Abstract: The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk1, Alk2, and W are as defined and described herein.
    Type: Application
    Filed: July 22, 2011
    Publication date: July 25, 2013
    Applicant: SMARTCELLS, INC.
    Inventors: Zhiyu Chen, Thomas M. Lancaster, Todd C. Zion
  • Patent number: 8143325
    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 27, 2012
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20110263890
    Abstract: A compound of the formula wherein R1 and R1? are the same, and wherein R1 and R1? are each aromatic groups; and wherein R2 and R2? and R3 each, independently of the others, are alkylene groups, arylene groups, arylalkylene groups, or alkylarylene groups; or wherein, in embodiments, R1 and R1? can be the same or different, and wherein R1 and R1? each, independently of the other is an alkyl group having a least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, an alkylaryl group having at least one ethylenic unsaturation, or an aromatic group, provided that at least one of R1 and R1? is an aromatic group; and provided that neither of R1 or R1? is a photoinitiator group.
    Type: Application
    Filed: April 22, 2010
    Publication date: October 27, 2011
    Applicant: XEROX CORPORATION
    Inventors: Naveen Chopra, Michelle N. Chrétien, Barkev Keoshkerian, Jennifer L. Belelie, Peter G. Odell
  • Patent number: 8008523
    Abstract: A process for preparing monocarboxylic perfluoropolyethers of formula: A-O—(RF)z—(CFY)t—C(O)OX (I) wherein: X is H, C1-C10 alkyl, or an aryl group; Y=F, CF3; t=1, 2 or 3; A is a C1-C4 perfluoroalkyl end group; z=0 or 1; RF is a perfluorooxyalkylene chain; having a number average molecular weight in the range 180-8,000; comprising the following steps: a) one or more distillations of perfluoropolyethers (PFPE) of formula T-O—(RF)z-T? (II) wherein: z and RF are as above defined; T, T?, equal to or different from each other, are selected from acyl fluoride or carbonyl-containing functional end groups and non functional end groups to obtain one PFPE fraction of formula (II) wherein the difference between the minimum and the maximum molecular weight of the components is lower than or equal to 600; b) partial fluorination of the fraction obtained in a); c) esterification c1) and/or hydrolysis c2) of the mixture obtained in b); d) distillation of the product obtained in c2) or in c1).
    Type: Grant
    Filed: April 3, 2007
    Date of Patent: August 30, 2011
    Assignee: Solvay Solexis S.p.A.
    Inventors: Giuseppe Marchionni, Ugo De Patto, Pier Antonio Guarda
  • Patent number: 7772352
    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: August 10, 2010
    Assignee: Bezwada Biomedical LLC
    Inventor: Rao S. Bezwada
  • Patent number: 7615669
    Abstract: The present invention provides a process for producing highly pure fluoro-compounds by making use of N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: November 10, 2009
    Assignee: Tosoh F-Tech, Inc.
    Inventors: Norihisa Kondo, Akio Watanabe, Hiroki Kanezaki, Kosuke Kawada
  • Publication number: 20090162787
    Abstract: There are provided a compound represented by a general formula (b1-1) shown below suitable as an acid generator for a resist composition, a compound represented by a general formula (I) shown below suitable as a precursor for the compound represented by the general formula (b1-1), an acid generator, a resist composition, and a method of forming a resist pattern. [Chemical Formula 1] X-Q1-Y1—SO3?M+??(I) X-Q1-Y1—SO3?A+??(b1-1) (wherein, Q1 represents a bivalent linking group or a single bond; Y1 represents an alkylene group which may contain a substituent group or a fluorinated alkylene group which may contain a substituent group; X represents an aromatic cyclic group of 5 to 30 carbon atoms which contains a fluorine atom and may contain a substituent group; M+ represents an alkali metal ion; and A+ represents an organic cation.
    Type: Application
    Filed: December 3, 2008
    Publication date: June 25, 2009
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Takehiro Seshimo, Yoshiyuki Utsumi, Yoshitaka Komuro, Keita Ishiduka, Akiya Kawaue, Kyoko Ohshita
  • Patent number: 7494961
    Abstract: A process for preparing an oligomeric phenolic detergent composition comprising contacting an oil soluble alkylphenol with an alkaline earth metal base, an alpha amino acid, and a C1 to C6 aldehyde, in the in the presence of a C2 to C6 alkylene glycol and a C2 to C4 carboxylic acid; and reacting under reactive conditions at a temperature of from 150° C. to 225° C. The oligomeric phenolic detergent product can be employed in a lubricating oil.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: February 24, 2009
    Assignee: Chevron Oronite Company LLC
    Inventors: Vernon R. Small, Jesse Meyer
  • Patent number: 7294736
    Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: November 13, 2007
    Assignee: Cambrex Charles City, Inc.
    Inventors: Paul Alan Jass, Jason Scott Douglas
  • Patent number: 6770775
    Abstract: A method of synthesizing highly optically enriched &agr;-halo-esters comprises reacting acid halides with a cinchona alkaloid catalyst and a base to form intermediate ketenes. The ketenes are reacted with electrophilic halogenating reagents to produce &agr;-halo-esters with high enantiomeric excess. The base can be an inorganic salt. The thus-formed &agr;-halo-esters have utility in synthesizing other optically-pure materials.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: August 3, 2004
    Inventor: Harald Wack
  • Publication number: 20040116725
    Abstract: The invention relates to a process for the preparation of acyloxybenzenesulfonates starting from carbonyl halides and salts of phenolsulfonic acid which have a low water content. Surprisingly, it was discovered that acyloxybenzenesulfonates can be prepared in high yields and good grades, irrespective of the grade or reactivity of the phenolsulfonic acid derivative, if the reaction of the phenolsulfonic acid with an alkanecarboxylic acid derivative is carried out in an aliphatic or aromatic solvent in the presence of 0.5 to 25% by weight of a polyglycol ether.
    Type: Application
    Filed: December 13, 2002
    Publication date: June 17, 2004
    Applicant: Clariant International, Ltd.
    Inventors: Wolf-Dieter Mueller, Peter Naumann
  • Patent number: 6743942
    Abstract: The present invention provides a process for transesterification of ketoester using polyaniline salt as catalyst, said process comprising reacting a keto ester with an alcohol in presence of a catalyst at a temperature range of 50 to 120° C. for a period in the range of 4 to 24 hours and separating the esters from the reaction mixture.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: June 1, 2004
    Assignee: Council of Scientific & Industrial Research
    Inventors: Srinivasan Palaniappan, Rampally Chandrashekhar
  • Publication number: 20040086460
    Abstract: New types of hydroxamic acid-based bifunctional chelators are provided. These chelators are designed to chelate metal ions that can be detected either by their paramagnetic or radioactive properties. Conjugation with peptides or protein can be achieved by the presence of a linker moiety in the molecular structure of these chelators.
    Type: Application
    Filed: August 4, 2003
    Publication date: May 6, 2004
    Inventor: Jean-Marc DuFour
  • Patent number: 6646152
    Abstract: A process for preparing 2-hydroxycarboxylic esters having a quaternary &bgr;-carbon atom by reaction of glycidyl esters with an organoaluminum reagent is described.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: November 11, 2003
    Assignee: Abbott GmbH & Co. KG
    Inventors: Monika Knopp, Rolf Jansen
  • Patent number: 6620964
    Abstract: A description is given of a process for preparing dihydroxycarboxylic esters and of an overall process for preparing R-(+)-&agr;-lipoic acid.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: September 16, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Martin Jochen Klatt, Markus Niebel, Melanie Erhardt
  • Patent number: 6559334
    Abstract: The invention relates to novel optically active polymerizable dipeptides, to the process for the preparation thereof, to the polymerization thereof and to the use of the polymers as adsorbents for the chromatographic separation of enantiomers.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: May 6, 2003
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Lange, Michael Grosse-Bley, Bruno Bömer, Rolf Grosser, Franz-Peter Hoever
  • Patent number: 6410775
    Abstract: aPL analogs that (a) bind specifically to B cells to which an aPL epitope binds and are disclosed. Optimized analogs lack T cell epitope(s) are useful as conjugates for treating aPL antibody-mediated diseases. Conjugates comprising aPL analogs and nonimmunogenic valency platform molecules are provides as are novel nonimmunogenic valency platform molecules and linkers. Methods of preparing and identifying said analogs, methods of treatment using said analogs, methods and compositions for preparing conjugates of said analogs and diagnostic immunoassays for aPL antibodies are disclosed.
    Type: Grant
    Filed: September 24, 1998
    Date of Patent: June 25, 2002
    Assignee: La Jolla Pharmaceutical Company
    Inventors: Edward Jess Victoria, David Matthew Marquis, David S. Jones, Lin Yu
  • Patent number: 6369267
    Abstract: Triazine, benzotriazole and benzophenone derivatives which are substituted or bridged with polyoxyalkylene groups, according to claim 1, and their use as UV absorbers, especially in photographic materials, in inks, including inkjet inks and printing inks, in transfer prints, in paints and varnishes, organic polymeric materials, plastics, rubber, glass, packaging materials, in sunscreens of cosmetic preparations and in skin protection compositions.
    Type: Grant
    Filed: October 4, 2000
    Date of Patent: April 9, 2002
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Vien Van Toan, Andreas Valet, Pascal Hayoz
  • Patent number: 6359165
    Abstract: Enantiomerically pure &bgr;-hydroxy esters are prepared by a process in which &bgr;-keto esters are reacted with hydrogen in the presence of catalysts of the formula LRuX2 where X is halogen, acetate, allyl, methallyl, 2-phenylallyl, perchlorate, trifluoroacetate, tetrafluoroborate, hexafluoroantimonate, hexafluorophosphate, hexafluoroarsenate or trichloroacetate, L is a bidentate phospholane of the formula I  where B=a bridging link with 1-5 carbon atoms between the two phosphorus atoms, R1=H, C1-C6-alkyl, aryl, alkylaryl or SiR23, R2=alkyl or aryl, m=0 or 1, R3=H or OR4, and R4=R1, with the proviso that if m=1 then R3=H and if m=0 then R3 ≠ H.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: March 19, 2002
    Assignee: BASF Aktienegesellschaft
    Inventors: Rainer Stürmer, Martin Jochen Klatt, Armin Börmer, Jens Holz, Gudrun Voss
  • Patent number: 6284918
    Abstract: The present invention provides a compound of the formula wherein when X is S; R is selected from the group consisting of CH3, CH2CH3, CH2Ph, (CH2)2Ph, (CH2)2CH3, (CH2)3CH3, (CH2)4CH3, CH2)5CH3, (CH2)6CH3, (CH2)2O(CH2)3CH3, CH2HC═CH(CH2)3CH3, CH2C≡C(CH2)3CH3, CH2C≡C(CH2)2CH3, CH2C≡CCH2CH3, CH2C≡CCH3, CH2C≡CH, CH2C≡C(CH2)4CH3, CH2C≡C(CH2)5CH3, CH2C≡C(CH2)6CH3, (CH2)2C≡C(CH2)2CH3, CH(Ch3)C≡C(CH2)3CH3, (CH2)6I, (CH2)6Br, (CH2)5Br, (CH2)5COOH and (CH2)5OCOCH3, and R′ is selected from the group consisting of CH3, CF3, CH2Cl, CH2Br, CH2CH3, NH2, and OSO2CH3; wherein when R is CH3, R′ can not be CH3 or CH2Cl; wherein when R is CH2CH3, R′ can not be CH3; wherein when X is Se, R is (CH2)6CH3, and R′ is CH3 or a pharmaceutically acceptable salt or hydrate thereof; and wherein when X is O, R is CH2C≡C(CH2)3CH3, and R′ is CH3 or a pharmaceutically acceptable salt or hydrate thereof.
    Type: Grant
    Filed: April 6, 1999
    Date of Patent: September 4, 2001
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Amit S. Kalgutkar
  • Patent number: 6248839
    Abstract: The invention relates to polymethacrylate acid-polyalkylene oxide block copolymers, to a process for their preparation and to their use as dispersants or suspension stabilizers for pigments and fillers, e.g. for metal oxides in ceramic materials, for pigments in inks used in ink jet printing and for fillers in thermosplastic and thermoset polymers.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: June 19, 2001
    Assignee: Th. Goldschmidt AG
    Inventors: Eberhard Esselborn, Jürgen Fock, Arno Knebelkamp
  • Patent number: 6229042
    Abstract: The invention relates to a process for the preparation of compounds of the general formula I in which R1 and R2 are identical or different and are a C1-C20-alkyl group, C3-C12-cycloalkyl group, C7-C12-aralkyl group or a mono- or binuclear aryl group, in which a ketone of the formula III or IV in which R1 and R2 have the above meaning, is asymmetrically hydrogenated.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: May 8, 2001
    Assignee: ASTA Medica Aktiengesellschaft
    Inventors: Rainer Gewald, Gunter Laban
  • Patent number: 6040338
    Abstract: The present invention relates to a compound of the formula wherein R.sup.1 and R.sup.2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms; R.sup.3 is a substituted or unsubstituted lower alkyl group having 1-6 carbons; and R.sup.4 is selected from substituted or unsubstituted lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms. The present invention also relates to a pharmaceutical composition comprising the above compound, as well as a method of treating tumor cells with the compound.
    Type: Grant
    Filed: November 3, 1997
    Date of Patent: March 21, 2000
    Assignee: Yale University
    Inventors: Alan C. Sartorelli, Krishnamurthy Shyam, Philip G. Penketh, Shu-Hui Chen
  • Patent number: 6025492
    Abstract: The present invention relates to the synthesis of a hydrazone .beta.-keto ester by the reaction of an alkyl diazoester with a hydrazone aldehyde in the presence of a Lewis acid In a preferred embodiment, the hydrazone .beta.-keto ester is then converted into a pyridazinone compound by the reaction with an alkyl acid chloride in the presence of a base, followed by acidification. A process for the production of a hydrazone aldehyde, which comprises contacting a hydrazine and glyoxal, is also described.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: February 15, 2000
    Assignee: Monsanto Company
    Inventors: Ajit S. Shah, Jerry D. Clark, Yinong Ma, James C. Peterson, Lefteris Patelis
  • Patent number: 6013833
    Abstract: The invention relates to a process for the preparation of compounds of the general formula I ##STR1## in which R.sup.1 and R.sup.2 are identical or different and are a C.sub.1 -C.sub.20 -alkyl group, C.sub.3 -C.sub.12 -cycloalkyl group, C.sub.7 -C.sub.12 -aralkyl group or a mono- or binuclear aryl group, in which a ketone of the formula III or IV ##STR2## in which R.sup.1 and R.sup.2 have the above meaning, is asymmetrically hydrogenated.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: January 11, 2000
    Assignee: Asta Medica Aktiengesellschaft
    Inventors: Rainer Gewald, Gunter Laban
  • Patent number: 5994577
    Abstract: The present invention provides novel compounds of the formula I and II for the treatment of non-insulin dependent diabetes mellitius (NIDDM) and a new use of known compounds for this purpose.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 30, 1999
    Inventors: Scott D. Larsen, Valerie A. Vaillancourt, Paul D. May, Steven P. Tanis, John A. Tucker, Martin D. Meglasson, Heinrich J. Schostarez
  • Patent number: 5985859
    Abstract: A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO.sub.2 H, PO.sub.2 H, or SO.sub.2 H; B is N; R.sub.1 and R.sub.2 are H; R.sub.3 and R.sub.4 are, independently, H, OH, NO.sub.2, guanidino, or alkyl or alkenyl of from 1 to 3 carbons where the alkyl or alkenyl is unsubstituted or is substituted, independently, with one or more of OH, NH2, or halide; R.sub.5 is H; and R.sub.6 is COCH.sub.3, or COCI.sub.3 ; or an analog, pharmaceutically acceptable salt, derivative, or mixture thereof. A method of preventing a bacterial or trypanosomal infection using the compounds of formula I. A method of treating a bacterial or trypanosomal infection using the compounds of formula I. A pharmaceutical composition comprising a pharmaceutically acceptable carrier admixed with an inhibiting effective amount of a compound of formula I.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignee: The University of Alabama
    Inventor: Ming Luo
  • Patent number: 5976812
    Abstract: The invention concerns activated amphetamine derivatives, a process for their production as well as their use for producing immunogens or detection conjugates carrying amphetamine groups. A further subject matter of the invention are new conjugates carrying amphetamine groups, a process for the production thereof as well as their use for the production of antibodies or for the determination of amphetamine or derivatives thereof.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: November 2, 1999
    Assignee: Roche Diagnostics GmbH
    Inventors: Erasmus Huber, Christian Klein, Rudolf Vogel, Bruno Zink, Wolfgang Rollinger
  • Patent number: 5973191
    Abstract: The present invention provides a compound of the formula ##STR1## wherein R is selected from the group consisting of CH.sub.3, CH.sub.2 CH.sub.3, (CH.sub.2).sub.2 CH.sub.3, (CH.sub.2).sub.3 CH.sub.3, (CH.sub.2).sub.4 CH.sub.3, (CH.sub.2).sub.5 CH.sub.3, (CH.sub.2).sub.6 CH.sub.3, (CH.sub.2).sub.2 O(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 HC.dbd.CH(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C.tbd.C(CH.sub.2).sub.3 CH.sub.3, CH.sub.2 C.tbd.C(CH.sub.2).sub.2 CH.sub.3, CH.sub.2 C.tbd.CCH.sub.2 CH.sub.3, CH.sub.2 C.tbd.CCH.sub.3 and CH.sub.2 C.tbd.CH; and R' is selected from the group consisting of CH.sub.3, CF.sub.3, CH.sub.2 Cl and CH.sub.2 Br or a pharmaceutically acceptable salt or hydrate thereof. Also provided is a method of inhibiting the synthesis of prostaglandin endoperoxide syntase-2 (PGHS-2) in a mammal.
    Type: Grant
    Filed: December 30, 1996
    Date of Patent: October 26, 1999
    Assignee: Vanderbilt University
    Inventors: Lawrence J. Marnett, Amit S. Kalgutkar
  • Patent number: 5847197
    Abstract: The invention relates to a process for the preparation of aminomalonic acid esters and optionally their salts by the catalytic hydrogenation of a substituted malonic acid ester in an inert solvent, and optionally by the addition of an acid to the hydrogenation mixture. The process comprises carrying out the hydrogenation in the presence of a solid dehydrating agent and a solvent or solvent mixture in which the aminomalonic acid ester salt is substantially insoluble.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: December 8, 1998
    Assignee: Huels Aktiengesellschaft
    Inventors: Frank Bauer, Marcel Feld
  • Patent number: 5783735
    Abstract: A process for preparing polymeric amides is disclosed. The process comprises sequentially reacting a hydrocarbon polymer functionalized (e.g., via the Koch reaction) to contain acid, ester, thioacid and/or thioester groups with a heavy polyamine to form a partially derivatized product in which at least about 85% of the functional groups are converted to heavy (thio)amide groups, and then reacting the partially derivatized product with an excess of light amine to complete the derivatization by converting substantially all of the remaining functional groups to light (thio)amide groups. Products of the foregoing process are also disclosed, which products are useful as additives in fuels and in lubricants.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: July 21, 1998
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Jacob I. Emert, Joseph V. Cusumano, David C. Dankworth, William D. Diana, William B. Eckstrom, Keith R. Gorda, Antonio Gutierrez, Jon E. Stanat, Warren A. Thaler, Stephen Zushma
  • Patent number: 5780672
    Abstract: A process for the preparation of compounds of the formula (1) in which R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, which includes reacting alcohols or carboxylic acids of the formula (2) in which R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, with a fluorinating agent of the formula (3) as defined in the specification.
    Type: Grant
    Filed: July 11, 1996
    Date of Patent: July 14, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Sergej Pasenok, Wolfgang Appel
  • Patent number: 5756822
    Abstract: An acetamide derivative having the general formula (I): ##STR1## or a pharmacologically acceptable salt thereof; a synthetic intermediate of the above-mentioned acetamide derivative; a treating agent for peptic ulcer and for gastritis which comprises the above-mentioned compound having the general formula (I) as an effective ingredient, and a process for treating peptic ulcer and gastritis using the above-mentioned compound having the general formula (I), are disclosed.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: May 26, 1998
    Assignee: Kaken Pharmaceutical Co., Ltd.
    Inventors: Nobuo Ishiyama, Toshihiro Koyama, Mitsuo Hayashida, Katsuyuki Otsuka, Masahiro Fujii, Kunio Kimura, Yoshiyuki Hata, Nobuko Miyao
  • Patent number: 5756685
    Abstract: Protein, ligand and anti-ligand conjugated chelated metal radionuclides are provided for use in vivo. Intermediates are provided for preparing the compositions efficiently.
    Type: Grant
    Filed: July 12, 1996
    Date of Patent: May 26, 1998
    Assignee: NeoRx Corporation
    Inventors: Alan R. Fritzberg, Sudhakar Kasina
  • Patent number: 5723651
    Abstract: An economical process for producing .alpha.-L-aspartyldipeptide amide derivatives useful as sweeteners, by using amino protecting groups which can be removed by hydrolysis under acidic conditions, resulting in conversion of a .beta.-carboxyl acid ester to a carboxylic acid.
    Type: Grant
    Filed: December 28, 1995
    Date of Patent: March 3, 1998
    Assignee: Ajinomoto Co., Inc.
    Inventors: Toyoto Hijiya, Tadashi Takemoto, Ryoichiro Nakamura, Yusuki Amino, Naoko Sugiyama
  • Patent number: 5696282
    Abstract: A process comprises contacting, in the presence of a catalyst, hydrogen sulfide or a mercaptan such as, for example, n-dodecyl mercaptan with an .alpha.,.beta.-unsaturated carbonyl or .alpha.,.beta.-unsaturated cyano compound such as, for example, methyl acrylate wherein the catalyst comprises a pyridine derivative such as, for example, 4-(dimethylamino)pyridine or an ion exchange resin such as, for example, "AMBERLYST A-21" to produce a 3-hydrocarbylthio derivative of the .alpha.,.beta.-unsaturated carbonyl or .alpha.,.beta.-unsaturated cyano compound such as, for example, methyl 3-(dodecylthio)propionate.
    Type: Grant
    Filed: March 26, 1996
    Date of Patent: December 9, 1997
    Assignee: Phillips Petroleum Company
    Inventors: James E. Shaw, Harry Porter
  • Patent number: 5616546
    Abstract: Improved automatic dishwashing detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.
    Type: Grant
    Filed: October 23, 1995
    Date of Patent: April 1, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Gregory S. Miracle, Mark R. Sivik
  • Patent number: 5597390
    Abstract: A di- or tri-ester polyether unsaturated acid amine reaction product effective as a fuel additive for reducing intake valve deposits and octane requirement increase, as well as controlling combustion chamber deposits, in gasoline engines is disclosed together with fuel compositions and methods of making and using the same. Also disclosed are compositions and methods for dispersing deposits in lubricating oil products.
    Type: Grant
    Filed: September 25, 1995
    Date of Patent: January 28, 1997
    Assignee: Ethyl Corporation
    Inventor: John T. Loper
  • Patent number: 5595967
    Abstract: Improved detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.
    Type: Grant
    Filed: October 23, 1995
    Date of Patent: January 21, 1997
    Assignee: The Procter & Gamble Company
    Inventors: Gregory S. Miracle, Mark R. Sivik, Patti J. Kellett
  • Patent number: 5557008
    Abstract: A one pot process for the perfluoroalkylation and/or perfluoroacyloxylation of organic substrates is provided. The process comprises contacting a substrate with a perfluoroalkanoic anhydride in the presence of an inorganic peroxygen compound at a temperature of greater than 10.degree. C. Substrates that can be perfluoroalkylated and/or perfluoroacyloxylated include alkylbenzenes, halogenated aromatic compounds, alkoxybenzenes, aryl benzenes, and aromatic and aliphatic disulphides. Preferably, the perfluoroalkanoic anhydride is trifluoroacetic anhydride and the inorganic peroxygen compound is sodium percarbonate.
    Type: Grant
    Filed: September 6, 1995
    Date of Patent: September 17, 1996
    Assignee: Solvay Interox Limited
    Inventors: Craig W. Jones, William R. Sanderson, John P. Sankey
  • Patent number: 5552507
    Abstract: Diisocyanates containing carboxylic acid ester groups corresponding to the formula: ##STR1## in which R and R.sup.1 represent specified groups are produced by phosgenation of the corresponding diamines, optionally present in the form of an ammonium salt. These diisocyanates are useful as starting materials in the production of plastics containing urethane and/or urea groups and as starting materials for the production of intermediate products used for the production of such plastics.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: September 3, 1996
    Assignee: Bayer Aktiengesellschaft
    Inventors: Christian Wamprecht, Klaus Jost, Stefan Penninger
  • Patent number: 5534179
    Abstract: Improved detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: July 9, 1996
    Inventors: Gregory S. Miracle, Mark R. Sivik, Patti J. Kellett
  • Patent number: 5534180
    Abstract: Improved automatic dishwashing detergent compositions, especially granular detergents, comprising bleach activators which form multiperacids, especially specific monoquaternary substituted bis(peroxycarbonic) acids, upon perhydrolysis are provided.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: July 9, 1996
    Inventors: Gregory S. Miracle, Mark R. Sivik
  • Patent number: 5530143
    Abstract: (6S)-6,8-Dihydroxyoctanoic esters I ##STR1## (R.sup.1 =alkyl, cycloalkyl, aralkyl or aryl), are prepared by reducing a (3S)-3-hydroxyoctanedioic diester II ##STR2## (R.sup.2 =an R.sup.1 radical group) with a complex hydride and are mainly used as intermediates for synthesizing compounds of the type of liponic acid.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: June 25, 1996
    Assignee: BASF Aktiengesellschaft
    Inventors: Friedhelm Balkenhohl, Joachim Paust
  • Patent number: 5491170
    Abstract: .beta.-Carboxy sulfonyl compounds of the formula ##STR1## wherein R.sub.1 is aryl, R.sub.3 is hydrogen or alkyl, R.sub.3 and R.sub.4 are hydrogen or alkyl, Y is --O--, --S--, or --NR.sub.2 --, and R.sub.5 is alkyl or aryl are potent inhibitors of the enzyme acyl CoA:cholesterol acyltransferase (ACAT) and are thus useful for treating hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: February 13, 1996
    Assignee: Warner-Lambert Company
    Inventors: Helen T. Lee, Joseph A. Picard, Drago R. Sliskovic
  • Patent number: 5470997
    Abstract: The present invention is directed to novel amphetamine derivatives which are synthesized for the covalent attachment to antigens (proteins or polypeptides) for the preparation of antibodies or receptors to amphetamine and amphetamine metabolites. The resulting novel antigens may be used for the production of antibodies or receptors using standard methods. Once generated, the antibodies or receptors and the novel derivatives which are covalently attached to proteins, polypeptides or labels may be used in the immunoassay process.
    Type: Grant
    Filed: April 6, 1992
    Date of Patent: November 28, 1995
    Assignee: Biosite Diagnostics Incorporated
    Inventors: Kenneth F. Buechler, Joseph B. Noar, Si S. Moi
  • Patent number: 5470878
    Abstract: Therapeutic compounds have the formula:(X)j-(non-cyclic core moiety),j being an integer from one to three, the core moiety is non-cyclic and X is a racemic mixture, R or S enantiomer, solvate, hydrate, or salt of: ##STR1## *C is a chiral carbon atom, n is an integer from one to four (preferably from one to three), one or more carbon atoms of (CH.sub.2).sub.n may be substituted by a keto or hydroxy group, and m is an integer from one to fourteen. Independently, R.sub.1 and R.sub.2 may be a hydrogen, a straight or branched chain alkane or alkene of up to twelve carbon atoms in length, or --(CH.sub.2).sub.w R.sub.5, w being an integer from two to fourteen and R.sub.5 being a mono-, di- or tri-substituted or unsubstituted aryl group, substituents on R.sub.5 being hydroxy, chloro, fluoro, bromo, or C.sub.1-6 alkoxy. Or jointly, R.sub.1 and R.sub.2 form a substituted or unsubstituted, saturated or unsaturated heterocyclic group having from four to eight carbon atoms, N being a hetero atom. R.sub.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: November 28, 1995
    Assignee: Cell Therapeutics, Inc.
    Inventors: John Michnick, Gail E. Underiner, J. Peter Klein, Glenn C. Rice