Plural Rings In Acid Moiety Patents (Class 560/21)
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Patent number: 4088474Abstract: Compounds of the formula ##STR1## WHEREIN R is halogen, (C.sub.1 -C.sub.4)alkyl, halo-(C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, halo(C.sub.1 -C.sub.4)alkoxy, phenyl, --NO.sub.2, --NH.sub.2 or --CN;R' is (C.sub.1 -C.sub.4)alkyl or halogen;n is an integer of from 1 to 3;n.sub.1 is zero or an integer of from 1 to 3;Y is (C.sub.1 -C.sub.6)alkylene andX is --COOH, --COO--(C.sub.1 -C.sub.8)alkyl, --CONH.sub.2, --CONH--NH.sub.2, --CN or --COO--Cat,"Cat" being the cation of an inorganic or organic base, are useful as selective grass herbicides.Type: GrantFiled: April 8, 1975Date of Patent: May 9, 1978Assignee: Hoechst AktiengesellschaftInventors: Karl Matterstock, Peter Langeluddeke, Ernst-Friedrich Schulze
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Patent number: 4083863Abstract: Certain derivatives of cyclopropane carboxylic acid and their esters are useful and valuable intermediates for the preparation of broad spectrum pyrethroid type pesticides. The invention provides a novel method for the preparation of the derivatives of cyclopropane carboxylic acid and esters from stable sulfonium ylides.Type: GrantFiled: June 1, 1976Date of Patent: April 11, 1978Assignee: American Cyanamid CorporationInventor: William Wayne Brand
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Patent number: 4083848Abstract: Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.Type: GrantFiled: January 3, 1977Date of Patent: April 11, 1978Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masumi Itoh, Takashi Kamiya, Daijiro Hagiwara
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Patent number: 4082779Abstract: This invention relates to a novel carbamoylation method for the preparation of steroid phenolic N-disubstituted carbamate esters, and novel compounds in said method. Phenolic carbamate esters are useful for various purposes, for instance as pharmaceuticals, e.g. antitumor agents, as biocides, e.g. pesticides, and intermediates for preparing such useful compounds.Type: GrantFiled: June 24, 1976Date of Patent: April 4, 1978Assignee: Aktiebolaget LeoInventors: Hans Jacob Fex, Sten Krister Kristensson, Anders Robert Stamvik
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Patent number: 4081461Abstract: This invention relates to a novel carbamoylation method for the preparation of phenolic N-disubstituted carbamate esters, and novel compounds in said method. Phenolic carbamate esters are useful for various purposes, for instance as pharmaceuticals, e.g. antitumor agents, as biocides, e.g. pesticides, and intermediates for preparing such useful compounds.Type: GrantFiled: June 24, 1976Date of Patent: March 28, 1978Assignee: Aktiebolaget LeoInventors: Hans Jacob Fex, Sten Krister Kristensson, Anders Robert Stamvik
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Patent number: 4075409Abstract: The present invention relates to pharmacologically valuable new benzophenone derivatives having a pronounced sedative action on the central nervous system and some of which also possess muscle-relaxing and aggression-inhibiting properties. These new derivatives have the structural formula ##STR1## and the pharmaceutically-acceptable acid-addition salts thereof in which R.sub.1 and R.sub.2 are substituents selected from the group consisting of hydrogen, saturated and unsaturated alkyl groups having 1-4 carbon atoms; R.sub.3 is selected from the group consisting of --COOC.sub.3 H.sub.7, --COOC.sub.4 H.sub.9, --COOC.sub.6 H.sub.5, --C.sub.6 H.sub.5, ##STR2## whereby R.sub.4 is an aliphatic radical with 1 to 4 carbon atoms or phenyl and Y is an oxygen or sulfur atom; if m is O R.sub.3 is further selected from the group consisting of --COOCH.sub.3 and --COOC.sub.2 H.sub.Type: GrantFiled: October 21, 1974Date of Patent: February 21, 1978Assignee: Cassella Farbwerke Mainkur AktiengesellschaftInventors: Heinz Gunter Greve, Klaus Resag
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Patent number: 4073795Abstract: The preparation of racemic and optically pure tryptophans is described. The D-enantiomers of the 6-substituted compounds possess a potent sweetening capability. Novel intermediates are also disclosed.Type: GrantFiled: June 22, 1976Date of Patent: February 14, 1978Assignee: Hoffmann-La Roche Inc.Inventors: Andrew David Batcho, Urs Oskar Hengartner, Willy Leimgruber, John William Scott, Donald Valentine, Jr.
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Patent number: 4072705Abstract: Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X.sub.4 and X.sub.5 are hydrogen or lower alkyl, Y is hydrogen, hydroxy, etherified hydroxy, substituted amino, or N-attached heterocyclyl, X.sub.0 is O or OCH.sub.2 CH.sub.2 O, R' represents hydrogen, lower alkyl or acetyl; and acid-addition salts thereof, are novel and useful in pharmacy as hypolipaemiant, hypocholesterolaemiant and cholagogic agents or in the preparation of such agents.Type: GrantFiled: February 9, 1976Date of Patent: February 7, 1978Assignee: Orchimed S.A.Inventor: Andre Mieville
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Patent number: 4072760Abstract: Phenylethanolamines of the formula I ##STR1## wherein R is substituted phenyl or optionally substituted furyl, thienyl, or pyridyl, R.sub.5 is hydrogen, lower alkyl, or optionally substituted benzyl, R.sub.4, R.sub.6, R.sub.8, and R.sub.9 each are hydrogen or lower alkyl, R.sub.7 is hydrogen, halogen, or lower alkyl, Q is --CO--or --CH.sub.2 --, and L is hydrogen or lower alkylcarbonyl, and enantiomers, diastereoisomers and salts thereof; also, process for preparing the compounds. Compounds of the invention possess bronchosposmolytic activity.Type: GrantFiled: November 17, 1975Date of Patent: February 7, 1978Assignee: Pharmacia ASInventor: Kurt Hedegaard
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Patent number: 4070178Abstract: Diphenyl ethers of the formula ##STR1## whereinR.sup.1 is hydrogen or halogen,R.sup.2 is hydrogen, halogen, or cyano,R is ##STR2## wherein R.sup.3 is hydrogen, halogen, nitro, alkyl, or alkoxy,R.sup.4 is a divalent alkylene radical, andR.sup.5 is cyano or -COR.sup.6, wherein R.sup.6 is alkoxy, hydroxy or salt thereof, allyloxy, alkoxyalkoxy, amino, alkyl or dialkyl amino, aminoalkoxy, or alkyl or dialkylaminoalkoxy,And diphenyl sulfides, sulfoxides, and sulfones of the formula ##STR3## wherein R.sup.8 is hydrogen, halogen, cyano, nitro, alkyl, alkoxy, or trifluoromethyl,R.sup.2 is hydrogen, halogen or cyano,X is sulfur, sulfinyl, or sulfonyl, andR is as defined above,And compositions containing these compounds exhibit herbicidal activity.Type: GrantFiled: July 30, 1976Date of Patent: January 24, 1978Assignee: Rohm and Haas CompanyInventors: Wayne O. Johnson, Roy Y. Yih
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Patent number: 4069332Abstract: Compounds, compositions and methods of using the compounds of the formula as anti-allergics ##STR1## wherein X' is the same as X, X' is at the 3 or 4 position and is ##STR2##Type: GrantFiled: September 10, 1976Date of Patent: January 17, 1978Assignee: The Upjohn CompanyInventor: John B. Wright
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Patent number: 4067868Abstract: 2(1H)-Quinazolinone derivatives, which are useful as anti-inflammatory agents, are prepared by heating or hydrolyzing an acylurea derivative. The acylurea derivative can be prepared by either reacting an indole derivative with an oxidizing agent or reacting an imidazolidine derivative with water, an alkanol or ammonia.Type: GrantFiled: March 26, 1976Date of Patent: January 10, 1978Assignee: Sumitomo Chemical Company, LimitedInventors: Kikuo Ishizumi, Kazuo Mori, Michihiro Yamamoto, Masao Koshiba, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4064173Abstract: A process for the preparation of 9,10-seco-steroids of the formula ##STR1## WHEREIN R.sup.1 and R.sup.2 independently are hydrogen, amino, OR.sup.5, OCOR.sup.6 or NHCOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl and R.sup.6 is lower alkyl or phenyl; R.sup.3 is lower alkyl; R.sup.4 is oxo, ##STR2## wherein R.sup.13 is lower alkyl, lower alkoxy -- lower alkylene, tetrahydropyranyl or tetrahydrofuryl, R.sup.14 is lower alkyl or aryl and R.sup.15 and R.sup.16 are lower alkyl or taken together form lower alkylene or arylene, and n is 1 or 2 is disclosed. The 9,10-seco-steroids of this invention are useful intermediates for the preparation of steroids.Type: GrantFiled: January 23, 1976Date of Patent: December 20, 1977Assignee: Hoffmann-La Roche, Inc.Inventors: Jean-Marie Cassal, Andor Furst, Werner Meier
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Patent number: 4062886Abstract: Disclosed are monomers of the formula: ##STR1## WHEREIN R is ##STR2## R' is hydrogen or methyl; R" is alkyl of 1-10 carbon atoms;X and Y are independently selected from the group consisting of NO.sub.2, halogen, cyano and --CF.sub.3 ;Z is oxygen or dicyanomethylene;a and a' can range from 0-3; andn is 1-10.These monomers can be readily polymerized to polymers suitable for use in electrophotographic imaging members and methods.Type: GrantFiled: July 16, 1975Date of Patent: December 13, 1977Assignee: Xerox CorporationInventor: Sam R. Turner
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Patent number: 4061791Abstract: A method of treating mammals for allergy and anaphylactic reactions of a reagin or non-reagin mediated nature which comprises administering prophylactically to said mammal an anti-allergy or anaphylactic reaction effective amount of a compound of the formula ##STR1## Novel compounds and compositions are also claimed.Type: GrantFiled: December 29, 1975Date of Patent: December 6, 1977Assignee: The Upjohn CompanyInventors: Charles M. Hall, John B. Wright
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Patent number: 4060626Abstract: Indole-carboxylic acid compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl or alkoxy radical or halogen;R.sub.2 is halogen; lower alkyl or alkoxy radical; orR.sub.1 and R.sub.2 can together also form an alkylene bridge containing 3 to 5 carbon atoms, which can optionally contain one or more double bonds; and, but less preferably, when R.sub.1 is a lower alkyl or alkoxy radical, R.sub.2 can also be a hydrogen atom, and physiologically compatible salts and esters thereof,Are outstandingly effective as blood sugar-lowering agents.Type: GrantFiled: May 4, 1976Date of Patent: November 29, 1977Assignee: Boehringer Mannheim G.m.b.H.Inventors: Vladimir Hrstka, Manfred Hubner, Manfred Kuhr, Felix Helmut Schmidt, Walter Aumuller
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Patent number: 4057571Abstract: This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.Type: GrantFiled: February 24, 1975Date of Patent: November 8, 1977Assignee: American Cyanamid CompanyInventors: Charles Vincent Grudzinskas, Martin Joseph Weiss
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Patent number: 4055414Abstract: The disclosure herein relates to 2-halo-N-(N.sup.1 -hydrocarbyloxyoxalyl-N.sup.1 -acylaminomethyl)-2',6'-dialkylacetanilides, to a process for preparing these compounds, herbicidal compositions containing same and method of use to selectively control undesired vegetation in agricultural crops, e.g., monocotyledons such as wheat, sorghum and rice and dicotyledons such as sugarbeets and soybeans.Type: GrantFiled: March 11, 1976Date of Patent: October 25, 1977Assignee: Monsanto CompanyInventor: John P. Chupp
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Patent number: 4052514Abstract: Novel trihalosubstituted biphenylyl propionic and acetic acids and their derivatives are described together with processes for their preparation and composition of them. They are useful as anti-inflammatory agents.Type: GrantFiled: September 14, 1973Date of Patent: October 4, 1977Assignee: The Boots Company LimitedInventors: Stewart S. Adams, Bernard J. Armitage, John S. Nicholson
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Patent number: 4052436Abstract: Fluorene-2-glyoxylic acid, 7-substituted derivatives thereof, and ester derivatives thereof are disclosed as useful for the treatment of inflammatory conditions.Type: GrantFiled: August 17, 1976Date of Patent: October 4, 1977Assignee: E. R. Squibb & Sons, Inc.Inventors: Eric T. Stiller, Seymour D. Levine, Pacifico A. Principe, Patrick A. Diassi