Plural Rings In Acid Moiety Patents (Class 560/21)
-
Patent number: 4568382Abstract: Novel and highly effective herbicidal compounds in the diphenylether class are provided herein.Type: GrantFiled: December 2, 1983Date of Patent: February 4, 1986Assignee: GAF CorporationInventor: Kou-Chang Liu
-
Patent number: 4567288Abstract: The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains.The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group;n represents the values 1, 2 or 3;(R).sub.n may together with the benzene ring also form the naphthyl group;R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group;R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group;R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom,provided however that when R.sub.Type: GrantFiled: October 1, 1984Date of Patent: January 28, 1986Assignee: Pierre Fabre S.A.Inventors: Henri Cousse, Gilbert Mouzin, Bernard Bonnaud, Marie Charveron, Francois Fauran
-
Patent number: 4564385Abstract: This invention relates to certain herbicidally active substituted diphenyl ether oxime derivatives, herbicidal compositions of the same and the use thereof for preemergence and postemergence control of noxious plants, i.e., weeds.Type: GrantFiled: January 28, 1985Date of Patent: January 14, 1986Assignee: PPG Industries, Inc.Inventor: Dennis K. Krass
-
Patent number: 4560785Abstract: Novel phenylacetic ester derivatives (I) ##STR1## are produced by reacting ketoprofene with alkylene glycol compounds. The derivatives (I) are useful as a nonsteroidal antiphlogistic and analgesic agent with very reduced side effects comparing with sole use of ketoprofene.Type: GrantFiled: February 21, 1984Date of Patent: December 24, 1985Assignee: SS Pharmaceutical Co., Ltd.Inventors: Haruyoshi Honda, Susumu Sato, Kazuo Isomae, Junji Ookawa, Tsukasa Kuwamura
-
Patent number: 4554371Abstract: Arylcarbonylphenoxyalkylcarboxylic acids, and alkyl esters and salts thereof, are described. The compounds may be formulated into therapeutic compositions and administered to animals, including humans, for the treatment of hyperlipidaemia and related diseases.Type: GrantFiled: August 2, 1984Date of Patent: November 19, 1985Assignee: Societe de Recherches Industrielles S.O.R.I.Inventor: Bernard Majoie
-
Patent number: 4552974Abstract: A process for producing a diphenylmethane dicarbamate by reacting an N-phenylcarbamate with a methylenating agent is disclosed. The process is carried out by condensing N-phenylcarbamate in two steps using a combination of two different types of acid catalysts. The catalysts exhibit a strong catalyzing effect and yet can be readily separated from the reaction mixture. The process produces dineuclear diphenylmethane dicarbamates in high selectivity. The acid catalysts can be easily recovered from the reaction mixtures and put to another use.Type: GrantFiled: December 7, 1983Date of Patent: November 12, 1985Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Shinsuke Fukuoka, Tomonari Watanabe
-
Patent number: 4551264Abstract: New polyhalogenoaromatic compounds of Formula I ##STR1## wherein Y and Z are each independently alkyl, alkoxy or alkanoyl each of 1 to 12 C atoms, --COOR.sup.1, --O--CO--R.sup.1, CN, NO.sub.2, NH.sub.2 or OH;Q is one or two identical or different radicals selected from Ph, Cy, 1,4-bicyclo[2,2,2]octylene or 1,3-dioxane-2,5-diyl;X.sup.1 to X.sup.4 are each independently H, F, Cl or Br;R.sup.1 is alkyl of 1 to 4 C atoms, Ph--R.sup.2 or Cy--R.sup.2 ;R.sup.2 is alkyl or alkoxy each of 1-12 C atoms or CN;Ph is 1,4-phenylene; and Cy is 1,4-cyclohexylene,can be used as components of liquid-crystal dielectrics.Type: GrantFiled: March 14, 1983Date of Patent: November 5, 1985Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Rudolf Eidenschink, Michael Romer, Georg Weber
-
Patent number: 4551171Abstract: There is provided a new class of derivatives of 2-nitro-5-(substituted-phenoxy) phenylalkanone oximes and imines that have pre- and post-emergence herbicidal activity.Type: GrantFiled: February 1, 1980Date of Patent: November 5, 1985Assignee: Rhone-Poulenc, Inc.Inventor: Robert J. Theissen
-
Patent number: 4550205Abstract: The invention relates to new diphenyl ethers of the general formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a nitro group, an optionally halogenated alkyl, alkoxy or alkylthio group having 1-6 carbon atoms, or an alkanoyl group having 1-4 carbon atoms;Y is a nitrogen atom or a group of the formula CH or CCl;Z is a hydrogen atom, a halogen atom, a nitro group, an optionally halogenated alkyl group having 1-4 carbon atoms, or an alkanoyl group having 1-4 carbon atoms; n is 0-2;R.sub.1 is a hydrogen atom, or an alkyl or alkanoyl group having 1-4 carbon atoms;R.sub.2 and R.sub.3 are equal or different and represent hydrogen atoms or alkyl groups having 1-4 carbon atoms; andA is a group of the general formula ##STR2## wherein R.sub.4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms, or a cation of an alkali metal, alkaline earth metal or an alkylated or non-alkylated ammonium group, andR.sub.5 and R.sub.Type: GrantFiled: November 4, 1982Date of Patent: October 29, 1985Assignee: Duphar International Research B.V.Inventors: Gerard B. Paerels, Cornelis W. Raven
-
Patent number: 4544509Abstract: An arylamine is coupled with an aromatic compound in the presence of water, an inorganic nitrite, and an alkanoic acid containing 5-7 carbons. In a preferred embodiment of the invention, 2-(4-amino-3-fluorobenzene)propionitrile is coupled with benzene in the presence of water, sodium nitrite, and hexanoic acid to form a flurbiprofen intermediate.Type: GrantFiled: August 15, 1983Date of Patent: October 1, 1985Assignee: Ethyl CorporationInventor: Robert I. Davidson
-
Patent number: 4542233Abstract: Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.Type: GrantFiled: July 20, 1983Date of Patent: September 17, 1985Assignee: Biaschim S.p.A.Inventors: Oreste Piccolo, Aldo Belli, Giovanni Villa, Enrico Zen, Attilio Citterio
-
Patent number: 4537621Abstract: Diphenyl ethers of the formula ##STR1## where Z.sup.1, Z.sup.2, and Z.sup.3 and R have the meanings given in the description, are used for controlling undesirable plant growth.Type: GrantFiled: March 31, 1983Date of Patent: August 27, 1985Assignee: BASF AktiengesellschaftInventors: Adolf Parg, Hans Ziegler, Bruno Wuerzer
-
Patent number: 4536346Abstract: This disclosure describes novel substituted aralkanamidobenzoic acids and analogs thereof. These compounds are useful pharmaceutical agents for ameliorating atherosclerosis by inhibiting the formation and development of atherosclerotic lesions in the arterial wall of mammals.Type: GrantFiled: May 6, 1983Date of Patent: August 20, 1985Assignee: American Cyanamid CompanyInventors: Robert G. Shepherd, Janis Upeslacis
-
Patent number: 4531969Abstract: Optically active enantiomers of the formula I ##STR1## where R is a group of the formulae ##STR2## R.sub.1 and R.sub.2, among others, are halogen or CF.sub.3 and Z is a carboxyl, carboxylate, carboxylic acid ester, thioester, carbonamide, carboxylic acid anilide, carbohydrazide or thioamide group, are interesting herbicides the effect of which is considerably superior to that of the optically inactive racemates.Type: GrantFiled: December 20, 1978Date of Patent: July 30, 1985Assignee: Hoechst AktiengesellschaftInventors: Hans J. Nestler, Gerhard Horlein, Reinhard Handte, Hermann Bieringer, Friedhelm Schwerdtle, Peter Langeluddeke
-
Patent number: 4526997Abstract: The present invention is directed to novel anticoccidial compositions and methods of employing the same to control coccidiosis in poultry. These compositions comprise a polyether antibiotic and a second component which is a selected carbanilide.Type: GrantFiled: May 18, 1984Date of Patent: July 2, 1985Inventors: George O. P. O'Doherty, Albert J. Clinton
-
Patent number: 4526608Abstract: Substituted phenoxyphenylhydroxyamines and pyridyloxyphenylhydroxyamines, and the use thereof for the control of weeds.Type: GrantFiled: March 31, 1983Date of Patent: July 2, 1985Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
-
Patent number: 4526894Abstract: 4-Hydroxy-2-quinolone derivatives are useful for their anti-inflammatory, anti-allergenic, antitussive and expectorant activity. Pharmaceutical compositions containing said compounds and pharmaceutically acceptable salts thereof and methods of treating humans and animals are described herein.Type: GrantFiled: June 21, 1983Date of Patent: July 2, 1985Assignee: Nippon Shinyaku Co. Ltd.Inventors: Hiroshi Enomoto, Tadatoshi Nomura, Yoshiaki Aoyagi, Shoichi Chokai, Tatsuhiko Kono, Masao Murase, Kichiro Inoue, Masahiro Adachi
-
Patent number: 4523030Abstract: Substituted benzophenones of the formula ##STR1## in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example, as follows:a compound or a mixture of compounds of the formula ##STR2## in which X.sub.1 and X.sub.2 together represent a group of the formula --C(.dbd.O)--O that is bonded via the carbonyl group to the radical Ph and X.sub.3 represents hydrogen, or one of the radicals X.sub.1 and X.sub.3 represents a group of the formula --C(.dbd.O)--Z, the other represents hydrogen and X.sub.2 represents a group R'O-- in which R' represents hydrogen or a hydroxy-protecting group, is subjected to acid treatment and the primary product is decomposed solvolytically.Type: GrantFiled: June 7, 1984Date of Patent: June 11, 1985Assignee: Ciba-Geigy CorporationInventors: Georges Haas, Andreas von Sprecher, Pier G. Ferrini
-
Patent number: 4522647Abstract: Substituted phenoxyalkanediones and intermediates therefor, and the use of said compounds for the control of weeds.Type: GrantFiled: June 29, 1983Date of Patent: June 11, 1985Assignee: Zoecon CorporationInventors: Richard J. Anderson, Shy-Fuh Lee
-
Patent number: 4520199Abstract: 3-Alkoxy-4-substituted phenoxy alkanoic acid esters, derivatives thereof, and the use thereof for the control of weeds.Type: GrantFiled: August 13, 1982Date of Patent: May 28, 1985Assignee: Zoecon CorporationInventors: Gustave K. Kohn, Joe T. Bamberg
-
Patent number: 4515628Abstract: Novel diphenyl ether hydrazine derivatives, particularly 2-nitro-5 (nucleus-substituted phenoxy) phenylhydrazine derivatives are provided. They are useful as a selective herbicide having a high herbicidal acitivity and residual efficacy.Type: GrantFiled: July 28, 1981Date of Patent: May 7, 1985Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Takeo Yoshimoto, Akira Hosono, Joh Miki, Kengo Oda, Masaaki Ura, Naoki Sato, Teruhiko Toyama, Hajime Tachibana, Yuji Enomoto, Yasunobu Funakoshi, Takashi Fujita, Yoshikata Hojo
-
Patent number: 4511729Abstract: Nitrophenoxy- or nitrophenylthiobenzeneacetic acid esters are prepared by reacting a nitrophenoxy- or nitrophenylthiobenzene with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base. The products are useful as intermediates for the synthesis of pharmaceuticals, such as fenoprofen.Type: GrantFiled: March 10, 1983Date of Patent: April 16, 1985Assignee: Ethyl CorporationInventors: G. Patrick Stahly, Barbara C. Stahly
-
Patent number: 4509970Abstract: Novel substituted phenylphosphinyloxy- and phenylphosphinylthio-iminocarboxylates, synthesis thereof, intermediates therefor, and the use of said novel compounds for the control of weeds.Type: GrantFiled: December 17, 1981Date of Patent: April 9, 1985Assignee: Zoecon CorporationInventor: Shy-Fuh Lee
-
Patent number: 4504671Abstract: Aldoxime or ketoxime-O-alkanoic acid is prepared by transoximation of an aldehyde or ketone, the reaction being conducted in a liquid phase at a pressure below one atmosphere. Conversion of the aldoxime or ketoxime-O-alkanoic acid to the ester or salt form is also described.Type: GrantFiled: October 15, 1982Date of Patent: March 12, 1985Assignee: PPG Industries, Inc.Inventors: Dennis K. Krass, John C. Crano, Melvin S. Newman
-
Patent number: 4500341Abstract: Phenoxycarboxylic acid amide compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 are individually selected from hydrogen and methyl,R.sup.3 is hydrogen or alkyl with from 1 to 5 carbon atomsR.sup.4 is optionally substituted alkoxycarbonylalkyl, aminocarbonylalkyl or dialkylaminocarbonylalkyl, phenyl, or substituted phenyl wherein the substituent is at least one of the group consisting of alkyl, alkoxy or alkylthio of from 1 to 4 carbon atoms, carbalkoxy of from 2 to 4 carbon atoms, halogen, and nitro; orR.sup.3 and R.sup.Type: GrantFiled: October 21, 1981Date of Patent: February 19, 1985Assignee: Bayer AktiengesellschaftInventors: Heinz Forster, Ludwig Eue, Robert R. Schmidt
-
Patent number: 4499299Abstract: Compounds which antagonize the slow-reacting substance of anaphylaxis or components thereof, e.g., leukotrienes, in warm blooded animals as well as intermediates and methods for their preparation, pharmaceutical compositions and methods for their administration. The compounds are diphenyl carboxylic acids with particular linking groups between the individual phenyl rings and the carboxylic acid moiety. Particular utilities are to relieve asthma and inflammation in man.Type: GrantFiled: December 6, 1982Date of Patent: February 12, 1985Assignee: ICI Americas Inc.Inventors: Peter R. Bernstein, Alvin K. Willard
-
Patent number: 4495362Abstract: A process for preparing alkyl nitroacetates by reacting an alkyl phenyl carbonate with a nitroparaffin in a polar aprotic solvent in the presence of a cyanide ion. The process permits a higher reaction rate, and thus the reaction can be completed even at room temperature.Type: GrantFiled: November 4, 1982Date of Patent: January 22, 1985Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Tadatoshi Honda, Yoichi Hosono
-
Patent number: 4493731Abstract: Compounds of the formula ##STR1## exhibit, in the pre-emergence process and in the post-emergence process, a good herbicidal action against a number of dicotyledonous weeds, they are well tolerated in monocotyledonous crops, such as wheat, barley, rice, sorghum and maize, and are also selectively active in some dicotyledonous crops such as soy beans, groundnuts and the like.Type: GrantFiled: September 16, 1980Date of Patent: January 15, 1985Assignee: Hoechst AktiengesellschaftInventors: Gerhard Horlein, Hubert Schonowsky, Hermann Bieringer, Peter Langeluddeke
-
Patent number: 4485254Abstract: This process relates to the oxidation of phenoxytoluenes to phenoxybenzoic acids utilizing a hydrogen peroxide activated, bromide promoted cobalt catalyst which can be performed at atmospheric pressure and at moderate temperatures. These phenoxybenzoic acids can then be esterified and selectively nitrated to give the corresponding 2-nitro-5-(substituted)phenoxybenzoic acid esters. Alternatively the acids can be nitrated and then esterified.Type: GrantFiled: September 30, 1981Date of Patent: November 27, 1984Assignee: Rohm and Haas CompanyInventor: Charles M. Tanger
-
Patent number: 4482547Abstract: This invention relates to substituted-1,3,4-benzotriazepines of the formula ##STR1## wherein X and Y are each independently hydrogen, lower alkyl, halogen, lower alkoxy, nitro and hydroxyl; R.sub.1 and R.sub.3 are each independently hydrogen or alkyl; R.sub.2 is hydrogen, lower alkyl, cycloalkyl lower alkyl, phenyl, Ar lower alkyl, hydroxyl and sulfhydryl; m and n are each independently integers of 0 or 1 and when m is 0, n is 1 and vice-versa; and p and q are independently integers of 1 or 2. Also included in the invention are the substituted-1,3,4-benzotriazepine derivatives of tautomeric form when the substituent for R.sub.1 and/or R.sub.3 in the above formula is hydrogen. The compound of this invention may be used as antihypertensive agents.Type: GrantFiled: August 26, 1982Date of Patent: November 13, 1984Assignee: Hoechst-Roussel Pharmaceuticals Inc.Inventors: Lawrence L. Martin, Linda L. Setescak
-
Patent number: 4482732Abstract: An improved process for preparing diaryl esters of dicarboxylic acids is disclosed, in which the esterification reaction is optimized by removing water and other by-products of the reaction according to a predetermined pattern. The removal of water and other by-products of the esterification reaction is most easily carried out by a distillation means, and the rate of removal is controlled by varying the reflux ratio in the distillation means during the course of the esterification reaction. The diaryl esters so prepared are useful in making linear polyesters.Type: GrantFiled: September 24, 1982Date of Patent: November 13, 1984Assignee: Occidental Chemical CorporationInventor: Gautam R. Ranade
-
Patent number: 4482736Abstract: Herbicidally active compounds of the formula ##STR1## in which R.sup.1 represents a hydrogen or chlorine atom,R.sup.2 represents a hydrogen atom, a cyano group, an optionally substituted radical selected from alkyl, aryl, alkanoyl, benzoyl, alkoxycarbonyl, alkenoxycarbonyl, alkinoxycarbonyl, aralkoxycarbonyl and aryloxycarbonyl, or a radical of the general formula--COOM,in whichM represents a hydrogen atom, one equivalent of an alkali metal ion or alkaline earth metal ion or optionally substituted ammonium, andR.sup.3 represents a cyano group or a radical of the general formula ##STR2## wherein Y represents an oxygen or sulphur atom or an imino (NH) or alkylimino (Nalkyl) group,R.sup.4 and R.sup.5 independently of each other represent a hydrogen atom or a methyl group,n is 0 or 1 andZ represents an optionally substituted radical,Novel intermediates therefor are also shown.Type: GrantFiled: July 14, 1983Date of Patent: November 13, 1984Assignee: Bayer AktiengesellschaftInventors: Heinz Forster, Ludwig Eue, Robert Schmidt
-
Patent number: 4482733Abstract: An improved process for preparing diaryl esters of dicarboxylic acids is disclosed, in which the esterification reaction is optimized by gradually increasing the temperature at which the reaction is being conducted according to a predetermined pattern. The temperature increase should be a function of the degree of esterification. The diaryl esters so prepared are useful in making linear polyesters.Type: GrantFiled: September 24, 1982Date of Patent: November 13, 1984Assignee: Occidental Chemical CorporationInventor: Gautam R. Ranade
-
Patent number: 4478758Abstract: Schiff bases of aminocycloalkanecarboxylic acid esters of the formula ##STR1## where R, R.sup.1, R.sup.2, m and n have the meanings given in the description, are prepared by a novel process. The compounds are intermediates for the preparation of the corresponding aminocycloalkanecarboxylic acids and of esters thereof.Type: GrantFiled: June 29, 1982Date of Patent: October 23, 1984Assignee: BASF AktiengesellschaftInventors: Gunter Schulz, Ernst Buschmann, Bernd Zeeh
-
Patent number: 4476315Abstract: Nitroarylacetic acid esters are prepared by reacting a nitroaromatic compound which is devoid of halogen on the aromatic ring carrying a nitro group with an alpha,alpha-disubstituted acetic acid ester in an inert solvent and in the presence of a base so that the ester undergoes a nucleophilic substitution on an unsubstituted ring carbon of the nitroaromatic compound during which an alpha-substituent functions as a leaving group. Nitrobenzene acetic acids and their esters are useful intermediates for the synthesis of pharmaceuticals.Type: GrantFiled: December 23, 1982Date of Patent: October 9, 1984Assignee: Ethyl CorporationInventors: G. Patrick Stahly, Barbara C. Stahly
-
Patent number: 4469893Abstract: Diphenyl esters of the formula ##STR1## wherein R is hydrogen, carboxy, carboxylate salt or ester, formyl, cyano, alkyl, alkoxy, chloro, bromo, or N, N-dialkyl amino, are prepared by reacting a chloro-fluoro-benzotrifluoride with a nitro-phenoxide of the formula ##STR2## where R is defined above, and M is a cation of an alkali metal or an alkaline earth metal.Type: GrantFiled: March 22, 1982Date of Patent: September 4, 1984Assignee: Occidental Chemical CorporationInventors: David Y. Tang, Byron R. Cotter, Frederick J. Goetz
-
Patent number: 4460400Abstract: There are described novel dihydropyrones of the formula I ##STR1## wherein R.sub.1 and R.sub.2 independently of one another are each a C.sub.1 -C.sub.4 -alkyl group, or one of the two substituents is also hydrogen, or R.sub.1 and R.sub.2 jointly form a C.sub.2 -C.sub.6 -alkylene bridge, R.sub.3 is C.sub.1 -C.sub.4 -alkoxy, C.sub.2 -C.sub.6 -alkenyloxy, C.sub.2 -C.sub.4 -alkynyloxy, C.sub.1 -C.sub.4 -haloalkoxy, C.sub.3 -C.sub.5 -alkoxyalkoxy or hydroxyl, and X, Y and Z independently of one another are each hydrogen, halogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, C.sub.1 -C.sub.4 -haloalkyl, C.sub.1 -C.sub.4 -haloalkoxy, --S(O).sub.n -C.sub.1 -C.sub.4 -alkyl, --S(O).sub.n -C.sub.1 -C.sub.4 -haloalkyl, where n is 0, 1 or 2, or they are each C(O)OR.sub.4, where R.sub.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl, or they are each NO.sub.2, CN or NR.sub.5 R.sub.6, where R.sub.5 and R.sub.6 independently of one another are each hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.Type: GrantFiled: May 24, 1982Date of Patent: July 17, 1984Assignee: Ciba-Geigy CorporationInventors: Hans Tobler, Werner Fory
-
Patent number: 4455437Abstract: Herbicidally effective aminoalkyl esters of 2-nitro-5-(o-chloro-p-trifluoromethylphenoxy)-benzoic acid, and acid addition salts and quaternary ammonium salts thereof, are suitable for the selective control of weeds in crops of useful plants, for example soya bean and rice crops.The aminoalkyl esters correspond to the formula ##STR1## wherein A is a C.sub.2 -C.sub.4 -alkylene bridge or the direct bond, and ##STR2## is an open amino group, and ##STR3## is a cyclic amino group.Type: GrantFiled: December 28, 1979Date of Patent: June 19, 1984Assignee: Ciba-Geigy CorporationInventors: Dieter Durr, Otto Rohr, Beat Bohner
-
Patent number: 4452992Abstract: A novel process for the preparation of ethoxycarbonylmethyl 5-(2,6-dichloro-4-trifluoromethyl-phenoxy-2-nitro-.alpha.-phenoxy-propiona te of the formula ##STR1## by reacting ethoxycarbonylmethyl 3-(2,6-dichloro-4-trifluoromethyl-phenoxy)-.alpha.-phenoxy-propionate of the formula ##STR2## with nitric acid in the presence of sulphuric acid and in the presence of 1,2-dichloroethane at a temperature between -20.degree. C. and +150.degree. C.Type: GrantFiled: January 13, 1983Date of Patent: June 5, 1984Assignee: Bayer AktiengesellschaftInventor: Hans P. Sehnem
-
Patent number: 4450173Abstract: A short-acting .beta.-blocking compound of the formula ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: June 21, 1982Date of Patent: May 22, 1984Assignee: American Hospital Supply CorporationInventors: Paul W. Erhardt, Robert J. Borgman
-
Patent number: 4448982Abstract: This invention relates to a process for the preparation of hydroxy alkyl phenoxy benzoates in a purified state involving the reaction of ethylene or propylene carbonate and a phenoxy benzoic acid having the formula ##STR1## wherein X is O or S; G is selected from the group of nitro, halo, cyano or a hydrogen atom; L, M and N are independently selected from the group of halo, trihaloalkyl, lower alkyl, lower alkoxy and nitro or a hydrogen atom at a temperature within the range of from 90.degree. C. to 125.degree. C.Type: GrantFiled: April 15, 1983Date of Patent: May 15, 1984Assignee: GAF CorporationInventors: Kou-Chang Liu, Michael J. Brown
-
Patent number: 4448773Abstract: Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or .alpha.-naphthyl, each of which is further substituted,R.sub.1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, .beta.-alkoxyethyl, hydroxymethyl, triazolylmethyl, imidazolylmethyl, pyrazolylmethyl, alkylsulfinyl, alkylsulfonyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, alkylsulfinyloxy, dialkylaminosulfinyloxy, phosphoric or thiophosphoric esters or amides, or alkylcarbonyloxy,R.sub.7 is hydrogen or optionally-substituted methyl or ethyl, andR.sub.8 is alkyl optionally substituted by alkoxy,are microbicidally, in particular fungicidally, active. Preferred compounds are those in which Ar is 2-methylphenyl, 2-methoxyphenyl, 2-chlorophenyl or .alpha.-naphthyl, each of which is further substituted by azido, and each of R.sub.7 and R.sub.8 is methyl.Type: GrantFiled: April 22, 1982Date of Patent: May 15, 1984Assignee: Ciba-Geigy CorporationInventors: Peter Riebli, Hanspeter Fischer, Rudolph C. Thummel, Adolf Hubele
-
Patent number: 4442117Abstract: There are described novel homoserine derivatives of the formula (I) ##STR1## which possess valuable microbicidal properties. In the formula: Ar is substituted phenyl or naphthyl; R.sub.1 is C.sub.2 -C.sub.6 alkyl optionally interrupted by oxygen or sulfur, 2-furyl, 2-tetrahydrofuryl, 1H-1,2,4-triazolylmethyl, 1-imidazolylmethyl, 1-pyrazolylmethyl, C.sub.2 -C.sub.4 alkenyl or cyclopropyl, each of which is optionally substituted by halogen; R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; and B is halogen or an ester, thioester, sulfonic acid ester or sulfonic acid amide group. Additionally, where B is halogen, R.sub.1 may be halomethyl. The novel derivatives can be used for combating microorganisms harmful to plants, particularly for combating phytopathogenic fungi, and they have for practical requirements a very favorable curative and protective action for protecting cultivating plants, without the plants being impaired as a result of undesirable secondary effects.Type: GrantFiled: October 23, 1980Date of Patent: April 10, 1984Assignee: Ciba-Geigy CorporationInventors: Walter Kunz, Wolfgang Eckhardt, Adolf Hubele, Peter Riebli
-
Patent number: 4441913Abstract: Novel substituted phenoxypropionates of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently are a hydrogen atom or a C.sub.1 to C.sub.6 alkyl group,X is a hydrogen or halogen atom, nitro, C.sub.1 to C.sub.6 alkyl or C.sub.1 to C.sub.6 alkoxy,a and n each independently are 1 or 2, andAr is a group of the formula ##STR2## wherein Y is a trifluoromethyl group, a halogen atom ora nitro, cyano or C.sub.1 to C.sub.6 alkyl group, andb is 1, 2 or 3,and their use as herbicides.Novel intermediates of the formulae ##STR3## in which formulae R.sup.1, R.sup.2, X, a and n have the meanings given above andZ.sup.1 represents halogen.Type: GrantFiled: June 17, 1982Date of Patent: April 10, 1984Assignee: Nihon Tokushu Noyaku Seizo K.K.Inventors: Masahiro Aya, Junichi Saito, Kazuomi Yasui, Kozo Shiokawa, Koichi Moriya
-
Patent number: 4439617Abstract: Herein disclosed are N-naphthoylglycine derivatives having aldose reductase inhibiting activity. The derivatives are useful for treating diabetic complications.Type: GrantFiled: November 13, 1981Date of Patent: March 27, 1984Assignee: Ayerst, McKenna & Harrison Inc.Inventors: Kazimir Sestanj, Nedumparambil A. Abraham, Francesco Bellini, Adi Treasurywala
-
Patent number: 4439618Abstract: Optically active methyl esters of arylpropionic acids are prepared by reaction of the corresponding vinylaromatic compounds with carbon monoxide and methyl alcohol in the presence of a palladium catalyst system consisting of a palladium compound associated with optically active diphenyl-neomenthylphosphine and with trifluoroacetic acid, at substantially atmospheric pressure and at a temperature comprised between 20.degree. and 80.degree. C. There is dealt with particular regioselective and enantioselective catalysis conditions.The products obtained consist of esters of arylpropionic acids or of the corresponding acids obtainable from them, and are useful intermediates in the synthesis of organic compounds, particularly of pharmaceutical products.Type: GrantFiled: August 5, 1982Date of Patent: March 27, 1984Assignee: Montedison S.p.A.Inventors: Giuseppe Cometti, Gian P. Chiusoli
-
Patent number: 4438136Abstract: Novel bicyclo [2,2,1] heptanes and hept-2-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by a grouping --C(R).dbd.N--NHCO--(NH).sub.a --R' in which R is hydrogen, an aliphatic hydrocarbon residue, an aromatic residue or an aliphatic hydrocarbon residue substituted by an aromatic residue, a is 0 or 1 and R' is an aliphatic hydrocarbon residue, an aromatic residue, or an aliphatic hydrocarbon residue substituted directly or through an oxygen or sulphur atom by an aromatic residue. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.Type: GrantFiled: September 17, 1982Date of Patent: March 20, 1984Assignee: National Research Development CorporationInventors: Robert L. Jones, Norman H. Wilson
-
Patent number: 4435589Abstract: Process for the preparation of dimethyl succinylosuccinate, or the disodium salt thereof, by condensation of dimethyl succinate in a 35-45 percent by weight solution of sodium methylate in methanol, and a process for the preparation of dianilinodihydroterephthalic acids, the dimethyl esters and salts thereof, and of dianilinoterephthalic acids, and the dimethyl esters and salts thereof, starting from the disodium salt of dimethyl succinylosuccinate prepared according to the new process, without intermediate isolation.Type: GrantFiled: January 21, 1982Date of Patent: March 6, 1984Assignee: Bayer AktiengesellschaftInventors: Meinhard Rolf, Detlef-Ingo Schutze, Rutger Neeff, Hans-Volker Runzheimer
-
Patent number: RE31731Abstract: Compounds of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group,Y is a hydrogen atom, or a trihalomethyl group, andZ is an alkoxy group, an alkoxyalkoxy group, a hydroxyalkoxy group, an alkyl group, a halogen atom, an alkylamino group, a dialkylamino group, an alkylthio group, a carboxy group, a carbalkoxy group, a carboxyalkoxy group, a carbalkoxyalkoxy group, a carboxyalkyl group, a carbalkoxyalkyl group, a dialkylureido group, an alkanoylamino group, or carbalkoxyamino group,and compositions containing these compounds exhibit herbicidal activity.Type: GrantFiled: September 1, 1978Date of Patent: November 13, 1984Inventors: Horst O. Bayer, Colin Swithenbank, Roy Y. Yih
-
Patent number: RE31831Abstract: 2-nitro-5-(substituted-phenoxy)benzoic acids and esters salts, amides and acyl halides thereof comprise a class of compounds that are highly effective herbicides.Type: GrantFiled: June 25, 1981Date of Patent: February 12, 1985Assignee: Rhone-Poulenc AgrochimieInventor: Robert J. Theissen