Sulfur, Nitrogen, Halogen Or Additional Oxy In Alcohol Moiety Patents (Class 560/33)
  • Patent number: 9181380
    Abstract: The present invention provides a cross-linkable functionalized isocyanate composition comprising (1) a functionalized isocyanate product being the reaction product of (i) an isocyanate component having at least two isocyanate groups and (ii) an ethylenically unsaturated component having at least one functional group that is reactive with an isocyanate group of the isocyanate component and at least one ethylenically unsaturated group, wherein the isocyanate component and the ethylenically unsaturated component are selected so that the functionalized isocyanate product has at least three ethylenically unsaturated groups, (2) a monomer component comprising a cross-linking monomer having at least two ethylenically unsaturated groups, and (3) a reinforcing component. Embodiments of the invention being resins that have been cross-linked and cured demonstrate high heat deflection temperature and excellent tensile and flexural properties.
    Type: Grant
    Filed: March 31, 2008
    Date of Patent: November 10, 2015
    Inventor: Richard Austin Panther
  • Patent number: 9102784
    Abstract: The present disclosure is directed to an anticrater additive that is useful for providing a smooth surface to a cured layer of an electrocoating composition on a substrate. The anticrater additive comprises the reaction product of a polyisocyanate with an acrylic polymer having one isocyanate reactive functional group. The acrylic polymer can be an acrylic polymer that is terminated with a chain transfer agent. Also disclosed is an electrocoat composition comprising the anticrater additive and a substrate coated with a cured layer of the electrocoat composition.
    Type: Grant
    Filed: March 16, 2012
    Date of Patent: August 11, 2015
    Assignee: AXALTA COATING SYSTEMS IP CO., LLC
    Inventors: Jeffery W. Johnson, Michael E. Woodhouse, Alan E Smith
  • Publication number: 20150044264
    Abstract: Alkyl and/or alkenyl glycerol carbamate prepared by reacting a carbonate selected from the group consisting of glycerol carbonate, diglycerol carbonate, polyglycerol carbonate and mixtures thereof, with an amine of the general formula (I): HNR1R2??(I) wherein R1 represents a hydrogen atom or a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 1 to 22 carbon atoms and R2 represents a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 4 to 22 carbon atoms, and cyclic alkyl groups having 5 or 6 carbon atoms, are described along with methods for their use as pearlizing agents in surface-active preparations.
    Type: Application
    Filed: August 4, 2014
    Publication date: February 12, 2015
    Inventors: Bin Gu, Brajesh Jha, Sithamalli Chandramouli, Jie Yang
  • Publication number: 20140275399
    Abstract: Novel fluorinated compounds, their method of preparation and use are disclosed, as well as the incorporation of new and old fluorinated compounds in controlled radical polymerization processes to efficiently produce polymer compositions with unique and enhanced properties. Various cure mechanisms and types of end-uses are disclosed.
    Type: Application
    Filed: April 4, 2014
    Publication date: September 18, 2014
    Inventors: Tianzhi Zhang, Matthew P. Burdzy, Dingsong Feng, Yonghui Zhang
  • Patent number: 8492499
    Abstract: The invention relates to addition compounds which are obtainable by reacting a) one or more polyisocyanates containing uretdione groups with b) one or more compounds of the formula (I) Y—(XH)n??(I) with the proviso that at least 50% of the free isocyanate groups of component a) are reacted with the compounds of the formula (I) to give an intermediate which contains uretdione groups, and subsequently the intermediate is reacted with c) one or more compounds of the general formula (II) Z—NHRm??(II) with the proviso that all free NCO groups optionally still present and at least 20% of uretdione groups originally used are reacted with Z—(NHR)m. The invention further relates to the use of the addition compounds as dispersants and dispersion stabilizers, and to a process for preparing them.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: July 23, 2013
    Assignee: BYK-Chemie GmbH
    Inventors: Karlheinz Haubennestel, Stefan Moessmer, Wolfgang Pritschins, Thomas Launag
  • Publication number: 20130090443
    Abstract: Carbamate and thiocarbamate compounds are described that comprise a polymerizable moiety and one or more free hydroxyl and/or thiol groups. Polymers may be obtained by polymerizing these carbamate and/or thiocarbamate compounds. The carbamate and thiocarbamate compounds, as well as the polymers they produce may be formulated into adhesive, agricultural, biocide, cleaning, coating, encapsulation, membrane, oilfield, performance chemical, and personal care compositions.
    Type: Application
    Filed: June 22, 2011
    Publication date: April 11, 2013
    Applicant: ISP Investments Inc.
    Inventor: Osama M. Musa
  • Patent number: 8362300
    Abstract: The present invention provides addition compounds, which suitable as dispersants and as dispersion stabilizers, and to the salts of the said compounds. The invention further provides processes for preparing these addition compounds, to their use as dispersants and dispersion stabilizers for organic and inorganic pigments and also fillers in organic and aqueous systems, and to pulverous or fibrous solids coated with such dispersants and intended for incorporation into liquid systems.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: January 29, 2013
    Assignee: BYK-Chemie GmbH
    Inventors: Wolfgang Pritschins, Udo Krappe, Karlheinz Haubennestel, Andrea Esser
  • Patent number: 8288566
    Abstract: Provided is an enantioselective, palladium-catalyzed method for the preparation of ?-amino-?,?-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: October 16, 2012
    Assignee: Novartis AG
    Inventors: Murat Acemoglu, Andreas Pfaltz, Claude Schaerer
  • Publication number: 20120219538
    Abstract: The present invention is directed to stable protein formulations, related methods and uses thereof. In particular, the invention relates to a method of stabilizing therapeutic proteins in aqueous solution.
    Type: Application
    Filed: November 1, 2010
    Publication date: August 30, 2012
    Applicants: THERAPEOMIC AG, UNIVERSITE DE GENEVE
    Inventors: Gerrit Borchard, Claudia Mueller, Martinus Anne Hobbe Capelle, Tudor Arvinte
  • Publication number: 20120203022
    Abstract: The content of the invention is a process for preparing urethanes by reaction of aromatic amines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 4-18 carbon atoms and is branched in the 2 position, and the reaction is performed in the presence of a substoichiometric amount of base, based on the amino groups.
    Type: Application
    Filed: October 20, 2010
    Publication date: August 9, 2012
    Applicant: BASF SE
    Inventors: Axel Franzke, Robert Baumann, Michael Bock
  • Patent number: 8222314
    Abstract: Urethane acrylates of the general Formula (I), corresponding salts, solvates or solvates of a salt thereof: wherein R1, R2, R3, R4 and R5 each independently represent a substituent selected from the group consisting of hydrogen, halogens, C1-6-alkyls, trifluoromethyl, C1-6-alkylthios, C1-6-alkylselenos, C1-6-alkyltelluros, and nitro groups, with the proviso that at least one of R1, R2, R3, R4 and R5 is not hydrogen; R6 and R7 each independently represent a substituent selected from the group consisting of hydrogen and C1-6-alkyls; and A represents a saturated or unsaturated or linear or branched C1-6-alkyl radical or a polyalkylene oxide radical having 2-6 ethylene oxide or propylene oxide units; processes for producing and methods of using the same.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: July 17, 2012
    Assignee: Bayer MaterialScience AG
    Inventors: Thomas Roelle, Friedrich-Karl Bruder, Thomas Fäcke, Marc-Stephan Weiser, Dennis Hönel
  • Publication number: 20110313057
    Abstract: The present invention relates to compounds of formula I, which are difunctionalized aromatic compounds, and polymers formed from the same. [R?—(X)a—OC(O)]p—Ar—[NR?—(Y)b—R?]q??I Polymers formed from the difunctionalized aromatics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: August 13, 2011
    Publication date: December 22, 2011
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S. Bezwada
  • Patent number: 8058468
    Abstract: The invention relates to the field of antibiotic compositions, both inside and outside the medical field. Presented is a new class of antibiotic compounds around the lead compound (3,4-dichloro-phenyl)-carbamic acid 2-isobutoxycarbonylamino-1-methyl-ethyl ester, which are especially useful for combating infections with gram-positive bacteria and especially MRSA.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: November 15, 2011
    Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventors: Frank Henri Johan Schuren, Henricus Matheus Wilhelmus Maria Thijssen, Roy Christiaan Montijn
  • Publication number: 20110263873
    Abstract: Provided is an enantioselective, palladium-catalyzed method for the preparation of ?-amino-?,?-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
    Type: Application
    Filed: November 16, 2009
    Publication date: October 27, 2011
    Inventors: Murat Acemoglu, Andreas Pfaltz, Claude Schaerer
  • Publication number: 20110124601
    Abstract: The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(?O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(?O)—O—C(R8)(R9)—OC(?O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(?O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substi
    Type: Application
    Filed: July 22, 2009
    Publication date: May 26, 2011
    Inventors: Bernard Roques, Hervé Poras, Marie-Claude Fournie-Zaluski
  • Publication number: 20110105782
    Abstract: A process is described for the preparation of carbamates of primary and/or secondary polyamines, which process comprises the steps of vaporising a primary and/or secondary polyamine and reacting said vaporised primary and/or secondary polyamine with gaseous carbon dioxide. In particular, the process relates to the production of the carbamates of hexamethylenediamine, 1,4-diaminocyclohexane and 3-aminomethyl-3,5,5-trimethylcyclohexylamine.
    Type: Application
    Filed: April 18, 2005
    Publication date: May 5, 2011
    Inventor: Maurizio Masi
  • Publication number: 20110070544
    Abstract: There is provided an acid having a fluorine-containing carbanion structure or a salt having a fluorine-containing carbanion structure, which is represented by the following general formula (1). By using a photoacid generator for chemically amplified resist materials that generates this acid, it is possible to provide a photoacid generator which has a high sensitivity to the ArF excimer laser light or the like, of which acid (photo generated acid) to be generated has a sufficiently high acidity, and which has a high dissolution in resist solvent and a superior compatibility with resin, and a resist material containing such a photoacid generator.
    Type: Application
    Filed: March 10, 2009
    Publication date: March 24, 2011
    Applicant: Central Glass Company,Ltd.
    Inventors: Masashi Nagamori, Satoru Narizuka, Susumu Inoue, Takashi Kume
  • Publication number: 20100286434
    Abstract: New ethylenically unsaturated monomers are provided that can be (co)polymerized to provide a composition and method whereby the same group that is attached to or within the backbone of an associative thickener is reversibly switched between being hydrophilic and hydrophobic in nature. When the group that is attached to or within the backbone is rendered hydrophilic, the aqueous thickener is pourable and readily incorporated into aqueous polymer compositions. When this group is rendered hydrophobic, the thickener performs its thickening function efficiently. Switching is readily accomplished by adjusting the pH of the associative thickener composition and the aqueous polymer composition being thickened. The thickeners are prepared from the novel monomers by an aqueous solution polymerization.
    Type: Application
    Filed: May 28, 2010
    Publication date: November 11, 2010
    Inventors: Barrett Richard Bobsein, Melissa Merlau Johnson, Thomas Glenn Madle, John Joseph Rabasco
  • Publication number: 20100063144
    Abstract: There is provided a compound of formula (I) wherein R1a, R2a, R3, X1 to X6, a, b and c have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, inhibitors of HDAC enzyme activity, and thus, in particular, in the treatment of conditions where inhibition of HDAC enzyme activity is required.
    Type: Application
    Filed: October 24, 2007
    Publication date: March 11, 2010
    Applicant: IMPERIAL INNOVATIONS LTD
    Inventors: Eric Ofori Aboagye, David Michael Vigushin, Wendy Vigushin
  • Publication number: 20090281335
    Abstract: The present invention provides compound(s) selected from the group of compounds represented by structural Formula (I): wherein X, Y and R1 are as described herein, use of such compounds as anaerobic cure accelerators, and compostions including such compounds.
    Type: Application
    Filed: May 7, 2008
    Publication date: November 12, 2009
    Applicant: HENKEL CORPORATION
    Inventors: Andrew Messana, Anthony F. Jacobine, Steven Thomas Nakos, David M. Glaser
  • Patent number: 7563938
    Abstract: The present invention is directed to novel alkylated aromatic compositions, zeolite catalyst compositions and processes for making the same. The catalyst compositions comprise zeolite Y and mordenite zeolite having a controlled macropore structure. The present invention is also directed to the preparation of the catalyst compositions and their use in the preparation of novel alkylated aromatic compositions. The catalyst compositions of the present invention exhibit reduced deactivation rates during the alkylation process, thereby increasing the life of the catalysts.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: July 21, 2009
    Assignees: Chevron Oronite Company LLC, Chevron Oronite S.A.
    Inventors: Curt B. Campbell, Thomas V. Harris, Pierre Tequi, Jean-Louis Le Coent
  • Patent number: 7563937
    Abstract: The present invention is directed to a zeolite Y catalyst having a controlled macropore structure. The present invention is also directed to a zeolite Y catalyst composite and a process for preparing the catalyst composite. The catalyst composite exhibits reduced deactivation rates during the alkylation process, thereby increasing the life of the catalyst. The present invention is also directed to processes for the preparation of carbonated, overbased aromatic sulfonates, which processes comprise alkylation, carbonation of aromatic hydrocarbons with one or more olefins.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: July 21, 2009
    Assignees: Chevron Oronite Company LLC, Chevron Oronite S.A.
    Inventors: Thomas V. Harris, Curt B. Campbell, Paul J. Marcatntonio, Pierre Tequi, Jean-Louis Le Coent
  • Patent number: 7560483
    Abstract: The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: July 14, 2009
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy X. Zhou
  • Patent number: 7531684
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Grant
    Filed: September 28, 2007
    Date of Patent: May 12, 2009
    Assignee: Synthon BV
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • Patent number: 7414146
    Abstract: This invention relates to an imaging element comprising an imaging layer having associated therewith a compound of Structure I: In the above Structure I, the substituents are as defined in the application. Such compounds have good reactivity and can by used to block photographically useful compounds such as developing agents until thermally activated under preselected conditions. Compounds according to the present invention are especially useful in color photothermographic imaging elements.
    Type: Grant
    Filed: July 13, 2001
    Date of Patent: August 19, 2008
    Assignee: Carestream Health, Inc.
    Inventors: Wojciech K. Slusarek, Xiqiang Yang, David H. Levy
  • Publication number: 20080194633
    Abstract: Chemical entities that modulate smooth muscle myosin and/or non-muscle myosin, pharmaceutical compositions and methods of treatment of diseases and conditions associated with smooth muscle myosin and/or non-muscle myosin are described.
    Type: Application
    Filed: August 1, 2007
    Publication date: August 14, 2008
    Inventors: Xiangping Qian, Pu-Ping Lu, Chihyuan (Grace) Chuang, Bradley P. Morgan, David J. Morgans
  • Publication number: 20080176338
    Abstract: This invention concerns novel labeling reactants suitable for labeling of a biospecific binding reactant using solid-phase synthesis. The novel reactants are derivatives of diethylenetriaminepentaacetic acid (DTPA), wherein a suitable group is linked to the DTPA molecule, thus allowing site specific introduction of the ligand of said derivatives to bioactive molecules on solid phase in an oligopeptide synthesizer.
    Type: Application
    Filed: March 25, 2008
    Publication date: July 24, 2008
    Applicant: WALLAC OY
    Inventors: Jari HOVINEN, Jari Peuralahti, Veli-Matti Mukkala
  • Publication number: 20080154057
    Abstract: A process for making aminoalkylphenyl carbamates, especially rivastigmine, can use less severe conditions using bis(p-nitrophenyl)carbonate (IX) as a phenol activator compound.
    Type: Application
    Filed: September 28, 2007
    Publication date: June 26, 2008
    Inventors: Henar Tejedor Vinent, Arjanne Overeem, Lambertus Thijs
  • Patent number: 7329689
    Abstract: A compound having formula (I) and a process for the preparation thereof are described.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: February 12, 2008
    Assignee: Italfarmaco SpA
    Inventors: Massimo Pinori, Paolo Mascagni
  • Patent number: 7041863
    Abstract: The present invention is directed to a zeolite Y catalyst having a controlled macropore structure. The present invention is also directed to a zeolite Y catalyst composite and a process for preparing the catalyst composite. The catalyst composite exhibits reduced deactivation rates during the alkylation process, thereby increasing the life of the catalyst. The present invention is also directed to processes for the preparation of carbonated, overbased aromatic sulfonates, which processes comprise alkylation, carbonation of aromatic hydrocarbons with one or more olefins.
    Type: Grant
    Filed: July 20, 2005
    Date of Patent: May 9, 2006
    Assignees: Chevron Oronite Company LLC, Chevron Oronite S.A.
    Inventors: Thomas V. Harris, Curt B. Campbell, Paul J. Marcantonio, Pierre Tequi, Jean-Louis Le Coent
  • Patent number: 6972340
    Abstract: Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: December 6, 2005
    Assignee: Abbott Laboratories
    Inventors: Gang Liu, Bruce G. Szczepankiewicz, Zhonghua Pei, Zhili Xin, David A. Janowick
  • Patent number: 6927036
    Abstract: Disclosed is a method for synthesizing 1-(acyloxy)-alkyl derivatives of primary or secondary amine drugs from 1-acyl-alkyl derivatives of primary or secondary amine drugs, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amenable to scale-up. For example, 1-acyl-alkyl derivatives of gabapentin and pregabalin are oxidized to yield 1-(acyloxy)-alkyl derivatives of gabapentin and pregabalin, respectively.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 9, 2005
    Assignee: Xero Port, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy X. Zhou
  • Patent number: 6864285
    Abstract: The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathological conditions which can be controlled by stimulation and/or costimulation of this receptor
    Type: Grant
    Filed: July 7, 1999
    Date of Patent: March 8, 2005
    Assignee: Innovet Italia S.r.l.
    Inventors: Cristina Comelli, Francesco Della Valle, Maria Federica Della Valle, Gabriele Marcolongo
  • Publication number: 20040236119
    Abstract: The present invention relates to a process wherein a cyclic carbonate compound bearing an electrophilic group is reacted with a compound containing a nucleophilic group, especially an amine group. Such reactions permit to obtain urethane groups useful in polymer preparation, such as polyurethanes, or other urethane-containing polymers.
    Type: Application
    Filed: April 12, 2004
    Publication date: November 25, 2004
    Inventor: Jurgen Van Holen
  • Publication number: 20040067938
    Abstract: Novel quaternary amine containing compounds including their pharmaceutically acceptable isomers, salts, hydrates, solvates and prodrug derivatives having activity against mammalian factor Xa are described. Compositions containing such compounds are also described. The compounds and compositions are useful in vitro or in vivo for preventing or treating conditions in mammals characterized by undesired thrombosis.
    Type: Application
    Filed: November 3, 2003
    Publication date: April 8, 2004
    Inventors: Penglie Zhang, Robert M. Scarborough, Bing-Yan Zhu
  • Patent number: 6673889
    Abstract: Acrylate, or methacrylate, or allylic, functionalized polyfluorooxetanes are disclosed for use in radiation curable coating compositions. These acrylate, or methacrylate, or allylic, functionalized polymers provide improvements in wetting and surface properties that have previously been provided by migratory chemicals such as waxes and oils. The partially or fully fluorinated side groups of the fluorooxetanes are believed to be disproportionately present at the interfaces between the coating and the substrate and between the coating and the atmosphere.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: January 6, 2004
    Assignee: Omnova Solutions Inc.
    Inventors: Raymond J. Weinert, Guillermina C. Garcia, James E. Robbins, Aslam Malik
  • Patent number: 6642406
    Abstract: N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrogenation of a mixture of 3,3-dimethylbutyraldehyde and a precursor of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. In particular, N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester is produced using an acid salt of L-&agr;-aspartyl-L-phenylalanine 1-methyl ester or N-protected L-&agr;-aspartyl-L-phenylalanine 1-methyl ester. The production method is efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-&agr;-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: November 4, 2003
    Assignee: The NutraSweet Company
    Inventors: Indra Prakash, Zhi Guo, Steve Schroeder, Kurt L. Wachholder
  • Publication number: 20030187248
    Abstract: Novel arylisothiocyanate compounds are described that are useful for activating alcohol-containing macromolecules, for example polyethyleneglycols and cellulose, for covalent linkage to amino-groups of biomolecules, for example polypeptides such as antibodies, enzymes, and proteins.
    Type: Application
    Filed: March 25, 2002
    Publication date: October 2, 2003
    Inventor: Paul K. Smith
  • Publication number: 20030162990
    Abstract: 1
    Type: Application
    Filed: November 19, 2002
    Publication date: August 28, 2003
    Inventors: Paul Stanislaw Siedlecki, David Michael Glanville Martin
  • Publication number: 20030144542
    Abstract: Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension.
    Type: Application
    Filed: November 28, 2001
    Publication date: July 31, 2003
    Inventors: Gunnar J. Hanson, John S. Baran
  • Patent number: 6600062
    Abstract: The present invention provides a method for enantioselectively producing a nonracemic 6,7-dihydroxy geranyloxy compound from a geranyloxy compound. In particular, methods of the present invention involve enantioselectively epoxidizing the geranyloxy compound and hydrolyzing the epoxide moiety under conditions sufficient to produce the nonracemic 6,7-dihydroxy geranyloxy compound.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: July 29, 2003
    Assignees: DSM Catalytica Pharmaceuticals, Inc., Colorado State University Research Foundation
    Inventors: Robert Seemayer, Yian Shi
  • Publication number: 20030135066
    Abstract: Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension.
    Type: Application
    Filed: November 28, 2001
    Publication date: July 17, 2003
    Inventors: Gunnar J. Hanson, Baran S. John
  • Patent number: 6570034
    Abstract: The present invention relates to a novel blocked phenylenediamine developer useful, in reactive association, for enabling, on development, a non-magenta color, for example a cyan color, from a dye-forming coupler. In one embodiment, the developer has the property that the dye color formed with the coupler is distinctly different from the color formed by the same coupler with an oxidized form of the conventional developer 4-(N-ethyl-N-2-hydroxyethyl)-2-methylphenylenediamine. The invention is also directed to a light-sensitive silver-halide color photographic element comprising the blocked developing agent according to the present invention.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: May 27, 2003
    Assignee: Eastman Kodak Company
    Inventors: Richard P. Szajewski, Lyn M. Irving
  • Patent number: 6541653
    Abstract: The process disclosed herein satisfies the need in the art for an industrially viable oxidative carbonylation catalytic system, and is capable of producing carbamates at a significantly higher rate than those processes reported in journal and patent literature. This reaction process takes place via a reaction mechanism that does not involve drastic conditions. Specifically, the catalytic system of the present invention employs Group VIII metal catalysts and/or copper-based catalysts with halide promoters to produce carbamates through heterogeneous oxidative carbonylation at atmospheric pressure and relatively non-drastic temperatures in a gas-solid carbonylation process.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: April 1, 2003
    Inventors: Steven S. C. Chuang, Yawu Chi, Bei Chen, Pisanu Toochinda
  • Patent number: 6534220
    Abstract: Novel carbonate compounds and novel carbamate compounds comprise at least one carbonate or carbamate moiety that is directly bonded only to groups selected from the group consisting of alkyl groups, cycloalkyl groups, alkenyl groups, cycloalkenyl groups, alkynyl groups, cycloalkynyl groups, and combinations thereof, the groups optionally containing one or more catenary heteroatoms. At least one of the directly-bonded groups comprises at least one sulfonyl moiety. The compounds are useful as solvents for the electrolyte salts used in electrochemical devices.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: March 18, 2003
    Assignee: 3M Innovative Properties Company
    Inventor: James E. Garbe
  • Patent number: 6495719
    Abstract: Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Inhibition of histone deacetylase can lead to the histone deacetylase-mediated transcriptional repression of tumor suppressor genes. For example, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, such as hematopoiesis, and genetic related metabolic disorders, such as, cystic fibrosis and adrenoleukodystrophy.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: December 17, 2002
    Assignee: CircaGen Pharmaceutical
    Inventors: Hsuan-Yin Lan-Hargest, Robert J. Kaufman, Norbert L. Wiech
  • Publication number: 20020107266
    Abstract: Compounds and pharmaceutical compositions useful as anti-parasitic agents agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.
    Type: Application
    Filed: December 11, 2001
    Publication date: August 8, 2002
    Inventors: Marguerita Lim-Wilby, Joseph Edward Semple, Michael I. Weinhouse, Erick A. Goldman, Gian L. Araldi
  • Patent number: 6380250
    Abstract: The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: April 30, 2002
    Assignee: Allergan Sales, Inc.
    Inventor: Robert M. Burk
  • Patent number: 6380251
    Abstract: The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: April 30, 2002
    Assignee: Allergan Sales, Inc.
    Inventor: Robert M. Burk
  • Patent number: 6362359
    Abstract: The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate adduct or an NCO prepolymer, X represents OR′ or NHR′ and R′ represents a group which is inert to isocyanate groups under the conditions used to form the compound of formula I, R″ represents a divalent, linear or branched aliphatic group containing 2 to 10 carbon atoms, provided that there are at least two carbons between the oxygen atoms wherein the aliphatic group may optionally be substituted by heteroatoms to form ether or ester groups, and n is 2 to 6.
    Type: Grant
    Filed: December 1, 2000
    Date of Patent: March 26, 2002
    Assignee: Bayer Corporation
    Inventors: Sze-Ming Lee, Karen M. Henderson, Patricia B. Jacobs, Robert A. Sylvester, Douglas A. Wicks