Carbamic Acid Patents (Class 560/24)
  • Patent number: 9745254
    Abstract: The present invention relates to using a two-step (thermolysis) or one-pot process to prepare aliphatic diisocyanates from aliphatic diamines and diaryl carbonates. Polyisocyanates can also be prepared from polyamines and diaryl carbonates. The present synthetic processes do not apply phosgene or highly toxic reagents and chloro-solvents during the entire procedure.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 29, 2017
    Assignee: Great Eastern Resins Industrial Co., Ltd.
    Inventors: Shenghong A. Dai, Wei Hsing Lin, Yi-Syuan Guo
  • Patent number: 9409125
    Abstract: A method of increasing the overall mass transfer rate of acid gas scrubbing solids is disclosed. Various catalyst compounds for that purpose are also disclosed.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: August 9, 2016
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Joseph E. Remias, Cameron A. Lippert, Kunlei Liu
  • Patent number: 9249251
    Abstract: Compositions and methods for forming condensates and resin compositions are provided. In one embodiment, a condensate is formed from a reaction mixture including a triazine monomer, an arylhydroxy monomer, an aldehyde monomer and an acid catalyst having a pKa value of greater than 3.8. The condensates contain up to 28 wt. % of nitrogen and have a melt viscosity of 3,000 cps or less at 175° C. The condensates may have a solubility of at least 80 wt. % solids dissolved in an organic solvent for 120 hours or greater. Also disclosed are methods for the manufacture of the condensate as well as the condensate's use in fire-retardant epoxy resin compositions suitable for the manufacture of laminates for electronic applications. There is also disclosed a glycidylated triazine-arylhydroxy-aldehyde condensate of this invention.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: February 2, 2016
    Assignee: HEXION INC.
    Inventors: Ganapathy S. Viswanathan, Raman C. Subrayan, Vinay Malhotra
  • Patent number: 9242926
    Abstract: The invention relates to improved processes for the preparation of lacosamide. The invention also relates to a novel intermediate useful in the preparation of lacosamide. The invention also relates to process for the purification of lacosamide.
    Type: Grant
    Filed: June 12, 2014
    Date of Patent: January 26, 2016
    Assignee: CADILA HEALTHCARE LIMITED
    Inventors: Bipin Pandey, Kalpesh Shah
  • Publication number: 20150099636
    Abstract: The present invention provides diacylhydrazine ligands and chiral diacylhydrazine ligands for use with ecdysone receptor-based inducible gene expression systems. Thus, the present invention is useful for applications such as gene therapy, large scale production of proteins and antibodies, cell-based screening assays, functional genomics, proteomics, metabolomics, and regulation of traits in transgenic organisms, where control of gene expression levels is desirable. An advantage of the present invention is that it provides a means to regulate gene expression and to tailor expression levels to suit the user's requirements.
    Type: Application
    Filed: October 9, 2014
    Publication date: April 9, 2015
    Inventors: Robert Eugene HORMANN, Bing Li
  • Patent number: 8981143
    Abstract: Method of producing glycerol that includes mixing a peroxide stream with an olefenic alcohol stream to form a feed stream; processing the feed stream in a high shear device to produce a high shear dispersion of peroxide and olefinic alcohol, wherein the high shear device is configured with a rotor and a stator separated by a shear gap; and contacting the high shear dispersion with a catalyst in a reactor to produce glycerol.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: March 17, 2015
    Assignee: H R D Corporation
    Inventors: Abbas Hassan, Ebrahim Bagherzadeh, Rayford G. Anthony, Gregory G. Borsinger, Aziz Hassan
  • Publication number: 20150065711
    Abstract: Disclosed are linear discrete PEG constructs, which can be created and produced in a precise and reproducible way. Key to being able to do these things, where x in the discrete PEGx can vary from about 2 to about 64, is that the processes used to make each linear portion is controlled to give essentially one oligomer/one compound. Having a variable length linear discrete PEG construct that is (a) primarily an linear discrete PEG construct with diagnostic or therapeutic groups attached along a chain of attachment cores, which is attached to a preferential locator; (b) is an m-discrete PEG as the terminal construct on the linear portion, and “hidden”; (c or linear discrete PEG with a terminus group that can be either negatively or positively charged, or neutral; and any of the discrete PEG portions can be designed to be cleaved after entering the cell.
    Type: Application
    Filed: August 15, 2014
    Publication date: March 5, 2015
    Applicant: EquIP, LLC
    Inventor: Paul D. Davis
  • Patent number: 8940926
    Abstract: A method for producing carbamate including a urea production step; a carbamate-forming step; an ammonia separation step of absorbing the gas with water in the presence of carbonate to produce a gas absorption water, and separating ammonia; an aqueous alcohol solution separation step of separating an aqueous alcohol solution from the gas absorption water; an ammonia/carbon dioxide separation step of separating carbon dioxide gas from the aqueous ammonia solution in the gas absorption water from which the aqueous alcohol solution is separated; an aqueous ammonia solution reusing step of mixing the aqueous ammonia solution and carbonate with the water to be used for production of the gas absorption water.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: January 27, 2015
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Koji Takamatsu, Satoshi Kato, Takeshi Fukuda, Tetsuya Nakano, Masaaki Sasaki
  • Patent number: 8937083
    Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 20, 2015
    Assignee: DowAgroSciences, LLC
    Inventors: Noormohamed M. Niyaz, Negar Garizi, Yu Zhang, Tony K. Trullinger, Ricky Hunter, Ann M. Buysse, Asako Kubota, Paul Renee LePlae, Jr., Daniel Knueppel, Christian T. Lowe, Dan Pernich, David A. Demeter, Timothy C. Johnson
  • Patent number: 8871965
    Abstract: The content of the invention is a process for preparing urethanes by reaction of aromatic amines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 4-18 carbon atoms and is branched in the 2 position, and the reaction is performed in the presence of a substoichiometric amount of base, based on the amino groups.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: October 28, 2014
    Assignee: BASF SE
    Inventors: Axel Franzke, Robert Baumann, Michael Bock
  • Patent number: 8853439
    Abstract: The invention relates to improved processes for the preparation of lacosamide. The invention also relates to a novel intermediate useful in the preparation of lacosamide. The invention also relates to process for the purification of lacosamide.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: October 7, 2014
    Assignee: Cadila Healthcare Limited
    Inventors: Bipin Pandey, Kalpesh Shah
  • Patent number: 8828098
    Abstract: Non-fluorinated blocked polyurethanes are described as extenders and, particularly as textile auxiliaries, for use with fluorochemical polymers in treating substrates, for example fibrous substrates, such as textile fabrics or yarns. The polyurethane is prepared by reacting a polyisocyanate, a blocking agent, and a non-fluorinated isocyanate reactive compound having an average alkyl chain length of 24 to 50 carbon atoms.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: September 9, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Stewart H. Corn, Chetan P. Jariwala
  • Patent number: 8816036
    Abstract: Catalysts, which are free of tin, are described which are useful in the reaction between an isocyanate and an alcohol, which is a key step for preparing polyurethane polymers. The catalyst is a metal complex or salt of formula (1): [Zn(L1)l1(L2)l2(Y)x]??(1) in which: l1?1 and l2=0 or 1; with l1+l2=2, x=1 or 2, the symbol L1 represents a ligand which is a ?-dicarbonylato anion or the enolate anion of a ?-dicarbonyl compound or an acetylacetato anion derived from a ?-ketoester, when l1=2, the symbols L1 are identical or different, the symbol L2 represents an anionic ligand which is different from L1, and the symbol Y represents a neutral ligand; where the metal complex or salt C of formula (1) is not zinc diacetylacetonate.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: August 26, 2014
    Assignee: Bluestar Silicones France SAS
    Inventors: Christian Maliverney, Laurent Saint-Jalmes
  • Patent number: 8796345
    Abstract: A method to form a urethane material, the method comprises blending and reacting at least one isocyanate, at least one isocyanate reactive compound and a metallized polyhedral oligomeric silsesquioxane to provide said urethane material, the metallized polyhedral oligomeric silsesquioxane is a dimeric structure with general formula wherein M represents a metal providing a 6-coordinated metal center, x and y being 1, R1O and R2O represent an alkoxide bridging the 6-coordinated metal centers, R3OH and R4OH represent an alcohol ligand and each of R5, to R18 is selected from the group consisting of alkyl-, polyether- and polyester ligands.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: August 5, 2014
    Assignee: Huntsman International LLC
    Inventors: Rene Alexander Klein, Christina Marinus, Chris Ian Lindsay, Hendrikus Abbenhuis, Jos Wilting, Gijsbert Gerritsen
  • Patent number: 8791223
    Abstract: Methods of catalyzing chemical reactions are provided. A tri-substituted phosphine having at least one substituent that is an alkyl group is added as a catalyst to reaction mixtures. Reaction mixtures contain uretdiones, anhydrides, or isocyanate functional materials including isocyanurates, in various combinations with hydroxyl, thiol, and/or amine functional materials. Curable compositions comprising these catalysts and reaction mixtures are also provided.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: July 29, 2014
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Michael Zalich, Mark P. Bowman, Jonathan T. Martz, Stephen John Thomas, Gregory J. McCollum
  • Patent number: 8765993
    Abstract: The invention relates to the production of carbamates in a single reactor (one-pot) using solid catalysts, involving the reaction between at least one nitro compound, an organic carbonate of formula (OR)(OR?)C?O, a gas selected from hydrogen gas and a mixture of gases containing hydrogen and hydrogen precursor compounds, and a catalyst that has at least one metallic oxide and can also contain an element of groups 8, 9, 10 and 11 of the periodical table. The carbonates obtained can be transformed into their corresponding isocyanates.
    Type: Grant
    Filed: September 9, 2011
    Date of Patent: July 1, 2014
    Assignees: Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de Valencia
    Inventors: Avelino Corma Canós, Hermenegildo GarcíGómez, Raquel Juarez Marín
  • Patent number: 8735621
    Abstract: Carbamate preparation process comprising, the reaction between at least: an amine or polyamines, an organic carbonate of formula (OR)(OR?)C?O, a catalyst which is formed by at least a support selected from at least a metal oxide, a microporous material, a mesoporous material, an anionic laminar compound of hydrotalcite type or their derivatives or an organic polymer and which may further contain a metal from groups 8, 9, 10 and 11 of the periodical system. The carbonates obtained can be transformed in their corresponding isocyanates.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: May 27, 2014
    Assignees: Consejo Superior de Investigaciones Cientificas, Universidad Politecnica de Valencia
    Inventors: Avelino Corma Canós, Raquel Juarez Marin, Hermenegildo Garcia Gomez
  • Patent number: 8729290
    Abstract: Method of producing glycerol that includes mixing a peroxide stream with an olefenic alcohol stream to form a feed stream; processing the feed stream in a high shear device to produce a high shear dispersion of peroxide and olefinic alcohol, wherein the high shear device is configured with a rotor and a stator separated by a shear gap; and contacting the high shear dispersion with a catalyst in a reactor to produce glycerol.
    Type: Grant
    Filed: August 13, 2012
    Date of Patent: May 20, 2014
    Assignee: H R D Corporation
    Inventors: Abbas Hassan, Ebrahim Bagherzadeh, Rayford Anthony, Gregory Borsinger, Aziz Hassan
  • Publication number: 20140116293
    Abstract: The present invention relates to a cellulose acetate film for optical compensation and a retardation enhancer used therein, and relates to a cellulose acetate film which has a high retardation value in the thickness direction (Rth).
    Type: Application
    Filed: June 20, 2012
    Publication date: May 1, 2014
    Applicant: SK INNOVATION CO., LTD.
    Inventors: Won Yeob Kim, Min Joung Im, Seung Eon Lee, Hyo Shin Kwak, Myoung Lae Kim, Yong Gyun Cho
  • Patent number: 8637696
    Abstract: The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide ?-substituted-?-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected ?2-amino acids, which are essential for systematic conformational studies of ?-peptide foldamers.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: January 28, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Samuel Helmer Gellman, Yonggui Chi, Li Guo
  • Patent number: 8633176
    Abstract: The present invention provides choline alfoscerate-containing pharmaceutical preparations which have improved storage-stability and are easily taken. The present invention also provides a method for manufacturing pharmaceutical preparations comprising choline alfoscerate, which is easy and simple and is performed by normal manufacturing equipments.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: January 21, 2014
    Assignee: CTC Bio, Inc.
    Inventors: Bong-Sang Lee, Su-Jun Park, Do-Woo Kwon, Hong-Ryeol Jeon
  • Publication number: 20140012005
    Abstract: The present invention relates to a process for preparing chiral amino acids with excellent enantiomeric excesses.
    Type: Application
    Filed: December 22, 2011
    Publication date: January 9, 2014
    Applicant: Diverchim
    Inventors: Sylvain Darses, Nicolas Lefevre, Benoit Folleas, Jean-Louis Brayer
  • Publication number: 20130331599
    Abstract: Provided is a compound of the following formula (I) for preparing 4-(10B)borono-L-phenylalnine: wherein R group represents a protecting group and is selected from the group consisting of: tert-butoxycarbonyl (Boc) group, trityl (Trt) group, 3,5-dimethoxyphenylisopropoxycarbonyl(Ddz) group, 2-(4-Biphenyl)isopropoxycarbonyl (Bpoc) group, and 2-nitrophenylsulfenyl (Nps) group, and the compound has a 10B purity higher than or equal to 98% and an enantiomeric excess higher than or equal to 99%.
    Type: Application
    Filed: June 5, 2013
    Publication date: December 12, 2013
    Inventors: Chia-Cheng Shaw, Kuen-Wang Sheu, Shu-Fen Huang
  • Patent number: 8598297
    Abstract: Prepolymers are prepared by a reaction of a polyisocyanate and a hydroxylmethyl containing polyester polyol derived from a fatty acid. The prepolymers can be prepared having isocyanate, hydroxyl, or a variety of other reactive functional groups. The prepolymers are useful in making polyurethanes and other polymers, or a crosslinking agents.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: December 3, 2013
    Assignee: Dow Global Technologies LLC
    Inventors: Erdem Bedri, Debkumar Bhattacharjee, John N. Argyropoulos
  • Publication number: 20130303740
    Abstract: The invention relates to a method for producing urethanes or ureas or mixtures of urethanes and ureas by oxidative carbonylation of organic amines in the presence of carbon monoxide, oxygen and a catalyst, where the catalyst used is a transition metal complex containing the structural feature: [Mn+(O˜N˜O)2?](n-2)+(L)m(Z?)n-2 and the method is carried out under halogen-free reaction conditions. The invention further relates to transition metal complexes containing said structural feature and also to the use of such transition metal complexes as catalysts in the production of urethanes or ureas or mixtures of urethanes and ureas.
    Type: Application
    Filed: August 9, 2011
    Publication date: November 14, 2013
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Felix Gärtner, Andreas Jacob, Jörg Sundermeyer, Stephan Klein, Stefan Wershofen
  • Patent number: 8580997
    Abstract: Disclosed is a process for preparing single enantiomers of beta-amino phenylbutyric acid derivatives and pharmaceutically acceptable salts thereof, which affords the desired compounds having special optical configuration. The process comprises a step of chemical synthesis and a step of resolving the optical isomers of beta-amino phenylbutyric acid derivatives with a resolving agent. The resolving step comprises reacting the optical isomers with resolving agents, such as di-para-toluoyl-L-tartaric acid and di-para-toluoyl-D-tartaric acid. The obtained R-beta-amino phenylbutyric acid derivatives (I) have high optical purity, and the total yield of the accumulative resolution of the laevo and the dextro isomer is up to above 70%.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: November 12, 2013
    Assignee: Jiangsu Hengrui Medicine Co. Ltd.
    Inventors: Piaoyang Sun, Yongjiang Chen, Guangliang Yu
  • Publication number: 20130274503
    Abstract: C1-C6Alkyloxy- or benzyloxy-carbonyl esters of -{3-[(E)-(1-phenyl or naphthyl C1-C4alkyl)-imino]-propyl}-amino)-acetic acid, which are intermediates for producing known bridged monobactam compounds useful in the treatment of bacterial infections.
    Type: Application
    Filed: April 26, 2013
    Publication date: October 17, 2013
    Applicant: BASILEA PHARMACEUTICA AG
    Inventors: Marc Muller, Xiaoping Wu, Lin Xu
  • Patent number: 8541613
    Abstract: There is provided a process for producing an amide compound having an excellent harmful arthropod-controlling activity and represented by the formula (3): wherein R1, R2 and R3 independently represent a C1-C6 alkyl group optionally substituted with at least one halogen atom etc., R4, R5, R6 and R7 independently represent a halogen atom etc.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: September 24, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Yoshihiko Nokura, Hiroshi Ikegami, Markus Jachmann
  • Publication number: 20130244945
    Abstract: An object of the present invention is to provide a medicament and method for treating lissencephaly patients. The present invention provides a lissencephaly therapeutic or preventive agent comprising a compound represented by the general formula (I): wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa): wherein R4 is lower alkyl, R5 is lower alkylene, and m is an integer of 1 to 6; R2 is lower alkyl optionally substituted with phenyl; and R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
    Type: Application
    Filed: November 28, 2011
    Publication date: September 19, 2013
    Inventor: Shinji Hirotsune
  • Patent number: 8513453
    Abstract: The invention is directed to a process for preparing aromatic carbamates which comprises the reaction of an aromatic amine with an organic carbonate in the presence of a catalyst characterized in that Zn4O(OAc)6 is used as catalyst.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: August 20, 2013
    Assignee: Bayer MaterialScience AG
    Inventors: Stefan Wershofen, Stephan Klein, Anton Vidal-Ferran, Elisenda Reixach, Francese Xavier Rius-Ruiz
  • Publication number: 20130165657
    Abstract: The problem to be solved is to produce, at high yields with high purity, anhydrous crystals of a compound represented by formula (1) that is an important intermediate for preparation of FXa inhibitor compound (X) or a pharmacologically acceptable salt thereof, or a hydrate thereof. The solution thereto is an industrial preparation process that provides, with high purity, anhydrous crystals of a compound represented by the following formula (1), which is an intermediate for the production of FXa inhibitor compound (X) or a pharmacologically acceptable salt thereof, or a hydrate thereof, wherein Boc represents a tert-butoxycarbonyl group.
    Type: Application
    Filed: January 2, 2013
    Publication date: June 27, 2013
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Koutarou Kawanami, Hideaki Ishikawa, Masahiro Shoji
  • Publication number: 20130158270
    Abstract: An improved process for preparing dabigatran etexilate, as well as analogous compounds of formula 7, is described.
    Type: Application
    Filed: February 15, 2013
    Publication date: June 20, 2013
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Frieder GNAD, Stefan SCHMITT, Hermann MUELLER-BOETTICHER, Helmut HEITGER, Seigfried MEINECK, Rolf DACH, Ingo HEDDESHEIMER
  • Patent number: 8450301
    Abstract: The invention relates to the use of piperazine compounds of formula (I) or the agriculturally useful salts of piperazine compounds of formula (I) as herbicides, the variables in formula (I) being defined as cited in the claims and the description.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: May 28, 2013
    Assignee: BASF SE
    Inventors: Eike Hupe, Cyrill Zagar, Matthias Witschel, Toralf Kühn, William Karl Moberg, Liliana Parra Rapado, Frank Stelzer, Andrea Vescovi, Michael Puhl, Robert Reinhard, Bernd Sievernich, Klaus Groβmann, Thomas Ehrhardt, Michael Rack
  • Patent number: 8450516
    Abstract: The present invention relates to a novel catalyst for producing N-substituted carbamates, the preparation of the catalyst and an improved method for producing N-substituted carbamates from these novel catalysts. The active component of the catalyst is a heteropoly acid and the catalyst support comprises a metal oxide or a metalloid oxide. The catalyst can be used to promote the reaction of carbamate and amine, thereby generating N-substituted carbamates with high yield. In the presence of the catalyst, the reaction conditions are relatively mild, the catalytic activity and selectivity of the reaction are high, and the reaction time is relatively short. Furthermore, the catalyst can be conveniently separated from the reaction system and recycled. therefore, the catalyst can be used to facilitate the further scale-up test and commercial application.
    Type: Grant
    Filed: May 17, 2010
    Date of Patent: May 28, 2013
    Assignee: Bayer MaterialScience AG
    Inventors: Stefan Wershofen, Stephan Klein, Hongchao Li, Xinkui Wang, Qifeng Li, Maoqing Kang
  • Patent number: 8420850
    Abstract: The invention comprises compounds which are derived from a drug or a substance with therapeutic properties, and useful as reagents for the synthesis of biostable polymers including said drug in their backbone, namely polyurethanes, polyureas or polyurea urethanes that are biocompatible and biostable. The invention also comprises the processes for preparing the compounds and the polymers, and to the use of these polymers for the manufacture of medical devices.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: April 16, 2013
    Assignee: Iberhospitex, S.A
    Inventors: Lluis Duocastella Codina, Maria Molina, Ofir Arad, Jose Ignacio Borrell Bilbao, David Sanchez Garcia, Sofia Henriette Petterson Salom
  • Publication number: 20130079399
    Abstract: The present invention refers to the compounds corresponding to the following general formula (I): wherein: R?C4-C8 alkanoyl; and X?NH—R1 where R1?H, or an amine protecting group; and/or the pharmaceutically acceptable salts thereof. Preferred compounds according to the present invention are represented by the following formula (Ia): wherein: R?C4-C8 alkanoyl; and/or the pharmaceutically acceptable salts thereof. In a preferred embodiment, an object of the present invention is to provide 5-amino-2-(butyryloxy)benzoic acid and/or the pharmaceutically acceptable salts thereof, preferably hydrochloride salt. A further object of the present invention is represented by the use of the compounds of formula (Ia), in particular 5-amino-2-(butyryloxy)benzoic acid and/or pharmaceutically acceptable salts thereof, as a medicament and by the use thereof for the treatment of intestinal inflammatory diseases.
    Type: Application
    Filed: November 21, 2012
    Publication date: March 28, 2013
    Applicant: SOFAR SPA
    Inventor: Carla LABRUZZO
  • Publication number: 20130030210
    Abstract: The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide ?-substituted-?-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected ?2-amino acids, which are essential for systematic conformational studies of ?-peptide foldamers.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 31, 2013
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Samuel Helmer GELLMAN, Yonggui CHI, Li GUO
  • Patent number: 8344173
    Abstract: A cyclotriphosphazene represented by Formula 1 prepared by introducing a dendritic tetrapeptide and a hydrophilic polyethylene glycol into a cyclotriphosphazene ring, a method of preparing the same, and a drug carrier including the cyclotriphosphazene of Formula 1. The compound according to the present invention may form a strong molecular hydrogel in a very low concentration of 2 w/w % or less. Furthermore, the hydrogel prepared using the compound of Formula 1 exhibits biodegradability, thermosensitivity at around body temperature, biocompatibility with protein drugs, and an easy way to prepare along with a sustained release property without any burst effect in the early stage of release. Therefore, the present cyclotriphosphazene molecular hydrogel may be efficiently used as a drug carrier for a sustained release of a drug, particularly, a protein drug.
    Type: Grant
    Filed: April 28, 2009
    Date of Patent: January 1, 2013
    Assignee: CnPharm Co., Ltd.
    Inventors: Youn Soo Sohn, Yong Joo Jun, Sung Mo Choi
  • Publication number: 20120330030
    Abstract: Provided is an enantioselective, palladium-catalyzed method for the preparation of ?-amino-?,?-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
    Type: Application
    Filed: September 6, 2012
    Publication date: December 27, 2012
    Inventors: Murat Acemoglu, Andreas Pfaltz, Claude Shaerer
  • Publication number: 20120264840
    Abstract: A method to form a urethane material, the method comprises blending and reacting at least one isocyanate, at least one isocyanate reactive compound and a metallized polyhedral oligomeric silsesquioxane to provide said urethane material, the metallized polyhedral oligomeric silsesquioxane is a dimeric structure with general formula wherein M represents a metal providing a 6-coordinated metal center, x and y being 1, R1O and R2O represent an alkoxide bridging the 6-coordinated metal centers, R3OH and R4OH represent an alcohol ligand and each of R5, to R18 is selected from the group consisting of alkyl-, polyether- and polyester ligands.
    Type: Application
    Filed: December 8, 2010
    Publication date: October 18, 2012
    Applicant: Huntsman International LLC
    Inventors: Rene Alexander Klein, Christina Marinus, Chris Ian Lindsay, Hendrikus Abbenhuis, Jos Wilting, Gijsbert Gerritsen
  • Patent number: 8273363
    Abstract: The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: September 25, 2012
    Assignee: Bind Biosciences, Inc.
    Inventors: Stephen E. Zale, Mir Mukkaram Ali
  • Patent number: 8268887
    Abstract: In one aspect, the present invention provides a composition of a covalent conjugate of a GABA analog with a drug. In another aspect, the present invention provides methods for treating pain and neurological disorders using the conjugates of GABA analogs.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: September 18, 2012
    Inventor: Feng Xu
  • Publication number: 20120209022
    Abstract: The invention relates to improved processes for the preparation of lacosamide. The invention also relates to a novel intermediate useful in the preparation of lacosamide. The invention also relates to process for the purification of lacosamide.
    Type: Application
    Filed: September 23, 2010
    Publication date: August 16, 2012
    Applicant: CADILA HEALTHCARE LIMITED
    Inventors: Bipin Pandey, Kalpesh Shah
  • Publication number: 20120203022
    Abstract: The content of the invention is a process for preparing urethanes by reaction of aromatic amines with a dialkyl carbonate, wherein the alkyl radical of the organic dialkyl carbonate comprises 4-18 carbon atoms and is branched in the 2 position, and the reaction is performed in the presence of a substoichiometric amount of base, based on the amino groups.
    Type: Application
    Filed: October 20, 2010
    Publication date: August 9, 2012
    Applicant: BASF SE
    Inventors: Axel Franzke, Robert Baumann, Michael Bock
  • Patent number: 8236983
    Abstract: The present invention includes methods of making and methods of using peptidomimetics compositions that mimic ?-helical BH3 sequences in cells. The peptidomimetics can be used to mimic ?-helical BH3 sequences and kill cancer cells.
    Type: Grant
    Filed: January 13, 2009
    Date of Patent: August 7, 2012
    Assignee: Board of Regents, The University of Texas System
    Inventor: Jung-Mo Ahn
  • Patent number: 8222314
    Abstract: Urethane acrylates of the general Formula (I), corresponding salts, solvates or solvates of a salt thereof: wherein R1, R2, R3, R4 and R5 each independently represent a substituent selected from the group consisting of hydrogen, halogens, C1-6-alkyls, trifluoromethyl, C1-6-alkylthios, C1-6-alkylselenos, C1-6-alkyltelluros, and nitro groups, with the proviso that at least one of R1, R2, R3, R4 and R5 is not hydrogen; R6 and R7 each independently represent a substituent selected from the group consisting of hydrogen and C1-6-alkyls; and A represents a saturated or unsaturated or linear or branched C1-6-alkyl radical or a polyalkylene oxide radical having 2-6 ethylene oxide or propylene oxide units; processes for producing and methods of using the same.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: July 17, 2012
    Assignee: Bayer MaterialScience AG
    Inventors: Thomas Roelle, Friedrich-Karl Bruder, Thomas Fäcke, Marc-Stephan Weiser, Dennis Hönel
  • Patent number: 8217005
    Abstract: A method of providing a patient with controlled release of a phenolic opioid using a prodrug capable, upon enzymatic activation, of releasing the phenolic opioid through intra-molecular cyclization leading to formation of a cyclic urea, carbamate or thiocarbamate.
    Type: Grant
    Filed: May 24, 2007
    Date of Patent: July 10, 2012
    Assignee: Signature Therapeutics, Inc.
    Inventors: Thomas E. Jenkins, Aleksandr Kolesnikov
  • Patent number: 8183194
    Abstract: The present invention relates to certain ester and nitrile derivatives of formula (I): wherein one dotted line represents a carbon-carbon single or double bond and the other dotted lines each represent a carbon-carbon single bond; R1 is a hydrogen atom or a methyl group, R2 is a methyl or ethyl group, R3 is a hydrogen atom or a methyl group, R4 is a hydrogen atom or a methyl group or said R4 taken together with the bond between carbon atom 2 and 3 form a cyclopropane; and X represents a CN or a COOR5 group, R5 representing a C1-5 alkyl group; with the compound being in the form of any one of its pure stereoisomers or mixtures thereof. These compounds are useful perfuming ingredients.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: May 22, 2012
    Assignee: Firmenich SA
    Inventors: Christian Chapuis, Hervé Pamingle
  • Publication number: 20120088888
    Abstract: To provide a novel polyimide precursor or polyimide which can provide a liquid crystal alignment film having a low volume resistivity, a liquid crystal aligning agent containing these polymers, a liquid crystal alignment film and a novel diamine which is useful as the starting material of these polymers.
    Type: Application
    Filed: March 9, 2010
    Publication date: April 12, 2012
    Applicant: Nissan Chemical Industries, Ltd.
    Inventor: Masato Nagao
  • Patent number: RE43343
    Abstract: The invention relates to the inhibition of histone deactylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: May 1, 2012
    Assignee: Methylgene Inc.
    Inventors: Daniel Delorme, Rejean Ruel, Rico Lavoie, Carl Thibault, Elie Abou-Khalil