Ortho Fused Rings In Acid Moiety Patents (Class 560/56)
  • Patent number: 10414728
    Abstract: The present invention provides a method of treating one or more sodium channel related diseases or disorders in an individual, including related symptoms. The method comprises administering to the individual a tetrahydropyridine derivative in an amount effective to treat sodium channel related diseases or disorders in individuals. These compounds are generally categorized as Ritalin related compounds. The present invention also provides compounds for use in the treatment of and also for use in the manufacture of a medicament for the treatment of sodium channel related diseases or disorders in an individual. A method is further provided for the preparation and isolation of the derivatives of the compound of the present invention.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: September 17, 2019
    Assignee: CENNERV PHARMA (S) PTE LTD
    Inventors: Anil Kumar Ratty, Michael Entzeroth
  • Patent number: 9988624
    Abstract: The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols. This integrative platform utilizes a suite of HTP molecular tool sets to create HTP genetic design libraries, which are derived from, inter alia, scientific insight and iterative pattern recognition. The HTP genomic engineering platform described herein is microbial strain host agnostic and therefore can be implemented across taxa. Furthermore, the disclosed platform can be implemented to modulate or improve any microbial host parameter of interest.
    Type: Grant
    Filed: December 30, 2016
    Date of Patent: June 5, 2018
    Assignee: Zymergen Inc.
    Inventors: Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
  • Publication number: 20150148414
    Abstract: Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
    Type: Application
    Filed: October 24, 2014
    Publication date: May 28, 2015
    Inventors: Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
  • Publication number: 20150141506
    Abstract: Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the absolute stereochemistry and formula: In some cases R1 is leucine and R is selected from: OH, OCH3, OCH2CH3, OCH2CH2CH3, NH2, NHCH2CH2OH, NHCH3, N(CH3)2, NH(4-OH-3-benzoic acid).
    Type: Application
    Filed: May 23, 2013
    Publication date: May 21, 2015
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20150126763
    Abstract: The description provides processes for the regio and stereospecific synthesis of polyprenylatedquinone derivatives, such as Vitamin K1, K2 and Ubiquinone, exploiting dithioacetals, especially 1,3-dithiane, mediated Umpolung chemistry which works along a new concept “Inhibiting resonance delocalization (IRD)” to overcome isomerization generated due to delocalization of allyliccarbanion on the ?-electron cloud of an allylic systems by the conventional synthesis.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 7, 2015
    Inventors: Dilip S. Mehta, Priya Mohan, Mayank Shastri, Ted Reid
  • Patent number: 9005478
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; R3 is hydrogen, halogen, cyano, alkoxy, NHCOR9, NHSO2R9, COOR9, OCOR9, aryl, alkyl, alkenyl, cycloalkyl, or heterocyclic all either substituted or unsubstituted; R4 is hydrogen, alkyl, aryl, alkenyl, cycloalkyl, or heterocyclic all either substituted or unsubstituted; R5, R6, R7, and R8 are independently hydrogen, halogen, cyano, alkoxy, NHCOR9, NHSO2R9, COOR9, OCOR9, aryl, alkyl, alkenyl, cycloalkyl, alkoxyaryl or heterocyclic all either substituted or unsubstituted, or combine with each other, or R5 can combine with R4 to form a carbocyclic or heterocyclic ring; R9 and R10 are independently alkyl, alkoxy, aryl, naphthyl, styryl, alkenyl, cycloalkyl, alko
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: April 14, 2015
    Assignees: Kent Displays Incorporated, Kent State University
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Publication number: 20150064455
    Abstract: This invention relates to the direct grafting of a calixarene mostly onto the surface of a material, as well as to a grafting process, and certain calixarene intermediates useful for carrying the grafting process.
    Type: Application
    Filed: March 28, 2013
    Publication date: March 5, 2015
    Inventors: Ivan Jabin, Alice Mattiuzzi, Corlnne Lagrost, Philippe Hapiot, Olivia Reinaud
  • Patent number: 8921591
    Abstract: A production process for substituted phenylacetic acids or ester analogs thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogs thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 30, 2014
    Assignee: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Hanmin Huang, Chungu Xia, Pan Xie
  • Publication number: 20140323567
    Abstract: Disclosed herein are drug release polymer compounds and compositions comprising prostacyclin compounds of Formula (I), and methods of preparing the same.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 30, 2014
    Applicant: United Therapeutics Corporation
    Inventor: Peter Laing
  • Publication number: 20140315960
    Abstract: The present invention relates to novel depot formulations (prodrugs) comprising an immobility promoting unit linked via an ester to an active pharmaceutical ingredient, i.a. common NSAIDs. The novel depot formulations are suitable for intra-articular injections and are soluble at slightly acidic pH to facilitate ease of injection, and sparingly soluble at physiological pH thereby precipitating at the site of administration. The precipitate will slowly dissolve and the active drug is released from dissolved depot formulation following esterase mediated cleavage of the ester link between the immobility promoting unit and the active pharmaceutical agent.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 23, 2014
    Inventor: Claus Selch LARSEN
  • Publication number: 20140256730
    Abstract: Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
    Type: Application
    Filed: January 13, 2014
    Publication date: September 11, 2014
    Applicant: Corsair Pharma, Inc.
    Inventors: Cyrus K. BECKER, Jürg R. PFISTER, Gwenaella RESCOURIO, Meenakshi S. VENKATRAMAN, Xiaoming ZHANG
  • Patent number: 8829227
    Abstract: Esters produced by the catalyzed reaction of alcohols and acids or anhydrides are neutralized by treatment with an aqueous alkaline alkali metal salt solution in an amount that provides less than a stoichiometric amount of alkali metal salt in relation to the acidity of the crude ester and the amount of water present during the treatment is from 0.8 to 1.4 wt % of water based on the weight of crude ester. When using titanium as the esterification catalyst, the ester resulting from this process contains less than 0.01 ppm by weight of titanium residue, so that it is storage stable when stored in the presence of an antioxidant.
    Type: Grant
    Filed: May 24, 2006
    Date of Patent: September 9, 2014
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventors: Brady Compton, John Lyford, IV, Nicolaas Anthony De Munck, Aad Gerrit Oskam, Allen David Godwin, Leendert Johannes Van Dop
  • Publication number: 20140249093
    Abstract: The invention provides a carrier-linked prodrugs, wherein the biologically active moieties comprise at least one carboxylic acid and wherein the linkage between the drug moiety and linker is in the form of an ester wherein the hydroxyl group required for ester formation is provided by the linker moiety and the carboxyl group required for ester formation is provided by the drug moiety. The hydroxyl group of the linker is sterically hindered by the presence of an alkyl or aryl group on the carbon directly bound to or adjacent to the carbon carrying the hydroxyl group (?-carbon). The steric effect of the alkyl or aryl group enables greater control of the rate of hydrolytic degradation of such carrier-linked prodrugs.
    Type: Application
    Filed: August 10, 2012
    Publication date: September 4, 2014
    Applicant: Ascendis Pharma A/S
    Inventors: Dirk Vetter, Harald Rau
  • Publication number: 20140228591
    Abstract: The invention relates to the use of a substituted, chiral amino alcohol, comprising one or more structural units of the following formula (1), wherein the abbreviations A, Y, R1 and R3 to R5 have the following meanings: is a covalent bond or a hydrocarbon group, Y is a covalent bond or a hydrocarbon group that can have an oxygen atom at one of its ends through which it is bonded to R1, R1 is an aliphatic or heterocyclic or aromatic radical, the carbon chain of which may be interrupted by one or more B groups, R5 is selected from the group consisting of (a) aliphatic radicals, wherein individual carbon atoms may be replaced by oxygen atoms or carbonyl groups, and wherein the carbon chains of same radicals may be optionally interrupted by a B group, and (b) araliphatic, cycloaliphatic, aromatic and heterocyclic radicals, wherein the carbon chain can be interrupted by one or more B structural elements and/or by one or more D coupling groups, R3, R4 are hydrogen or aliphatic or araliphatic substituents, which are
    Type: Application
    Filed: October 10, 2012
    Publication date: August 14, 2014
    Applicant: Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung E.V.
    Inventors: Monika Bauer, Lutz Hartmann, Frank Kuschel, Wolfgang Weissflog
  • Patent number: 8765994
    Abstract: The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: July 1, 2014
    Assignee: The University of British Columbia
    Inventors: Raymond Andersen, David E. Williams, Alice Mui, Christopher Ong, Gerald Krystal, Lu Yang
  • Patent number: 8748462
    Abstract: The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I?A or I?B: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: June 10, 2014
    Assignee: Amgen Inc.
    Inventors: Sean P. Brown, Paul Dransfield, Xiaohui Du, Zice Fu, Jonathan Houze, XianYun Jiao, Sujen Lai, An-Rong Li, Jiwen Liu, Zhihua Ma, Julio C. Medina, Vatee Pattaropong, Wang Shen, Marc Vimolratana, Yingcai Wang, Zhongyu Wang, Ming Yu, Liusheng Zhu
  • Publication number: 20140121345
    Abstract: Provided is a liquid crystal alignment layer of which a constituent member is a compound represented by the general formula (I).
    Type: Application
    Filed: May 31, 2012
    Publication date: May 1, 2014
    Applicant: DIC CORPORATION
    Inventors: Martin Schadt, Sayaka Nose, Masayuki Iwakubo, Masanao Hayashi, Yutaka Nagashima, Isa Nishiyama, Haruyoshi Takatsu
  • Publication number: 20140121187
    Abstract: Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, flu, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
    Type: Application
    Filed: June 18, 2012
    Publication date: May 1, 2014
    Applicants: KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Young Sik Jung, Chong Kgo Lee, Ihl Young Choi, Hae Soo Kim, Pil Ho Kim, Soo Bong Han, Johan Neyts, Hendrik Jan Thibaut
  • Patent number: 8709281
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; and R3-R9 are as described in the disclosure. Also featured are liquid crystal compositions comprising a chiral dopant compound represented by any of Structure 2-4 as described in the disclosure.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: April 29, 2014
    Assignee: Kent State University
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Publication number: 20140107323
    Abstract: The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA, wherein the variables R1, R2, R3, Ra and L are described throughout the application.
    Type: Application
    Filed: March 22, 2012
    Publication date: April 17, 2014
    Inventors: Kyle Gee, Aimei Chen, Hee Chol Kang
  • Publication number: 20140107194
    Abstract: Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the formula: wherein R is selected from one or more of the same or different of hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted aryl, alkoxy, aryloxy, thiol, and optionally substituted amino, and wherein R1 is selected from one or more of the same or different of hydrogen, acetyl, optionally substituted alkyl, optionally substituted aryl, and an amino acid selected from leucine, valine, isoleucine, and glycine.
    Type: Application
    Filed: July 20, 2012
    Publication date: April 17, 2014
    Applicant: Venantius Limited
    Inventors: Neil Frankish, Helen Sheridan
  • Publication number: 20140100384
    Abstract: Provided is a process for making non-phthalate plasticizers, by acylating an aromatic compound with a succinic anhydride to form a keto-acid, and then esterifying the keto-acid with C4-C13 OXO-alcohols to form a plasticizer compound. The aromatic rings of the aromatic compound may also be optionally hydrogenated.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 10, 2014
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Jihad Mohammed Dakka, Edmund John Mozeleski, Lisa Saunders Baugh, Colle Karla Schall, Allen David Godwin, Diana S. Smirnova, Jorg Friedrich Wilhelm Weber, Stephen Zushma
  • Publication number: 20140080990
    Abstract: An object of the invention is to provide a polymerizable compound having small refractive index anisotropy and having high storage stability and high alignment properties when constituting a polymerizable liquid crystal composition, and provide a polymerizable liquid crystal composition containing the polymerizable compound. Further, the object is to provide a polymer produced by polymerizing the polymerizable liquid crystal composition and an optically anisotropic body including the polymer. The present invention provides a polymerizable compound represented by general formula (I), a polymerizable liquid crystal composition containing the compound as a constituent component, and further provides a polymer produced by polymerizing the polymerizable liquid crystal composition and an optically anisotropic body including the polymer.
    Type: Application
    Filed: April 5, 2012
    Publication date: March 20, 2014
    Applicant: DIC CORPORATION
    Inventors: Tetuo Kusumoto, Masahiro Horiguchi, Takashi Matsumoto, Yoshio Aoki, Masanao Hayashi, Masayuki Iwakubo
  • Patent number: 8653086
    Abstract: A compound (particularly useful for inhibiting cancer) according to formula I: or a pharmaceutically acceptable salt thereof, wherein: x is 0 or 1; R1-R6 are each independently H, —CN, —NO2, —NO, —OH, halogen, hydroxyalkyl, carboxyl, substituted carboxyl, aminocarbonyl, alkoxy, carbonyl or substituted carbonyl; R7 is H, alkyl, alkyl amino, aminoacyl, hydroxyacyl, heteroaryl, heterocycloalkyl, alkyl heteroaryl or alkyl heterocycloalkyl; R8 is H or alkyl; A is O or N; and Ar is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, provided that if R7 is H then Ar is aryl substituted with alkyl amino.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: February 18, 2014
    Assignee: Oregon Health & Science University
    Inventors: Xiangshu Xiao, Bingbing Li
  • Patent number: 8647878
    Abstract: The invention relates to an immersion liquid including at least one compound of the general formula I in which R1 and R2 each include at least one ring structure and X denotes: O, S, NR3 with R3 selected from hydrogen or hydrocarbon, wherein Y denotes independently of each other O, S or NR4 with R4 selected from hydrogen or hydrocarbon. In addition, the invention relates to a further immersion liquid, a compound for an immersion liquid and a use of the immersion liquids or of the compound as an immersion oil for a microscope, in particular for a near-field microscope.
    Type: Grant
    Filed: February 24, 2010
    Date of Patent: February 11, 2014
    Assignee: Carl Zeiss AG
    Inventor: Hans-Joachim Weippert
  • Publication number: 20140034883
    Abstract: The present invention relates to a polymerizable liquid crystal compound, a liquid crystal composition including the same, and an optically anisotropic body. The polymerizable liquid crystal compound according to the present invention has not only high birefringence but also excellent coating orientation, and thus it is possible to prepare a optically anisotropic body which is thin but superior in optical properties.
    Type: Application
    Filed: June 26, 2013
    Publication date: February 6, 2014
    Applicant: LG CHEM, LTD.
    Inventors: Kyung-Chang SEO, Sung-Ho Chun, Dai-Seung Choi, Mi-Ra Hong, Hyeong-Bin Jang
  • Publication number: 20140024785
    Abstract: An electronic device that serves as a high-brightness electroluminescent device includes a layer containing a polymer compound having one or more structural units selected from a structural unit represented by formula (1) and a structural unit represented by formula (7) as a charge injection layer and/or a charge transport layer: Wherein R1, R2, R6 and R7 represent certain groups; m1 and m5 represent an integer of 0 or more; when R2 and R7 are plurally present, they may be the same or different; and a hydrogen atom in formula (1) or (7) may be replaced with a substituent other than the certain groups.
    Type: Application
    Filed: March 27, 2012
    Publication date: January 23, 2014
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Masanobu Tanaka, Rui Ishikawa, Ken Sakakibara, Hideyuki Higashimura
  • Publication number: 20140012034
    Abstract: The present invention relates to a method for the production of cross-linked carbon nanotube networks which are selected from aerogels and xerogels with improved performance and characteristics thereof. The invention is also concerned with carbon nanotube networks which are selected from aerogels and xerogels produced by such processes and uses thereof.
    Type: Application
    Filed: November 15, 2011
    Publication date: January 9, 2014
    Applicants: KING ABDULAZIZ UNIVERSITY, BIO NANO CONSULTING
    Inventors: Milo Shaffer, Ainara Garcia Gallastegui, Abdullah Asiri, Shaeel Althabaiti
  • Publication number: 20130331593
    Abstract: Treprostinil is prepared by a process which involves Pauson-Khan cyclization of an an alkene-substituted, alkyne-substituted benzene corresponding to formula: (I) where PMB represents para-methoxy benzyl protecting group and R1 and R2 are alcohol protecting groups. Following cyclization, the resulting compound can be subjected to several chemical trans-formations followed by alkylation, hydrolysis and salt formation to yield treprostinil sodium. The use of para-methoxybenzyl group as the phenolic protecting group confers several process advantages that result in simplified purification of the final product and improved yields.
    Type: Application
    Filed: July 22, 2011
    Publication date: December 12, 2013
    Applicant: ALPHORA RESEARCH INC.
    Inventors: Graham Mcgowan, Walter Giust, Danielle Marie Di Donato, Teng-Ko Ngooi, Jan Oudenes
  • Publication number: 20130331556
    Abstract: A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Inventor: Xinyu Liu
  • Publication number: 20130303798
    Abstract: A production process for substituted phenylacetic acids or ester analogues thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogues thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.
    Type: Application
    Filed: December 20, 2012
    Publication date: November 14, 2013
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventor: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
  • Publication number: 20130281652
    Abstract: The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R?]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: October 17, 2012
    Publication date: October 24, 2013
    Inventor: Rao S. Bezwada
  • Publication number: 20130274240
    Abstract: The present invention provides an agent for the prophylactic or treatment of diabetes, diabetic complications, insulin resistance syndrome, metabolic syndrome, hyperglycemia, dyslipidemia, atherosclerosis, cardiac failure, cardiomyopathy, myocardial ischemia, brain ischemia, cerebral apoplexy, pulmonary hypertension, hyperlactacidemia, mitochondrial disease, mitochondrial encephalomyopathy or cancer, namely, a PDHK inhibitor and the like. A compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, or a solvate thereof: wherein each symbol is as defined in the specification.
    Type: Application
    Filed: November 5, 2012
    Publication date: October 17, 2013
    Inventor: JAPAN TOBACCO INC.
  • Patent number: 8487006
    Abstract: The present invention is directed to a method of enhancing TGF-? signaling in a subject comprising administering to said subject a clathrin-dependent endocytosis inhibitor in an amount sufficient to enhance TGF-? signaling. In another aspect, the invention is directed to a method of treating a condition associated with decreased TGF-? signaling in a patient in need thereof comprising administering to said patient a clathrin-dependent endocytosis inhibitor in a therapeutically effective amount.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: July 16, 2013
    Assignees: Auxagen, Inc., Saint Louis University
    Inventors: Jung San Huang, Shuan Shian Huang
  • Publication number: 20130168321
    Abstract: An activated carbon material for removing a contaminant from a liquid. The activated carbon material can be a plurality carbon grains that have a pore volume of approximately 0.1 milliliters per gram (mL/g) in the range of less than about 15 angstroms in width. The carbon grains can also have or contain a nitrogen-containing species having a concentration of more than 2 atomic percent nitrogen. A plurality of the carbon grains can be used to make a contactor that is operable to remove or reduce perchlorate having a concentration of 20 parts per billion (ppb) to less than 4 ppb from 4,500 bed volumes of water with the nitrogen-containing species leaching off of the carbon grains less than 0.1 mg/L. The activated carbon material can also be electrochemically regenerated.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 4, 2013
    Applicant: THE PENN STATE RESEARCH FOUNDATION
    Inventor: THE PENN STATE RESEARCH FOUNDATION
  • Publication number: 20130172558
    Abstract: Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compounds, which can be used in liquid crystal compositions useful for electro-optical and display device applications. The liquid crystal can be a ferroelectric liquid crystal. Also provided is a display device that includes the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound. Also provided is a method of preparing a liquid crystal display device on silicon that includes incorporating the Naproxen-based ferroelectric liquid crystal (FLC) or nematic liquid crystal chiral compound, into a liquid crystal display on silicon by disposing the compound in a liquid crystal, or the liquid crystal, onto a silicon surface.
    Type: Application
    Filed: January 4, 2012
    Publication date: July 4, 2013
    Inventors: Yongqiang Zhang, Kundalika More, William Thurmes
  • Patent number: 8465674
    Abstract: A compound represented by the formula (1) is provided. In the formula (1), for example, R1 and R2 are alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 2 to 10 carbons; the ring A and the ring B are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond and Z3 is —CH2O— or —OCH2—; Y1 and Y2 are halogen, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F; and m and n is 0, 1 or 2, p is 1 or 2, and the sum of m, n and p is 1, 2 or 3.
    Type: Grant
    Filed: August 9, 2010
    Date of Patent: June 18, 2013
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventor: Tokifumi Masukawa
  • Publication number: 20130140495
    Abstract: This disclosure includes a process that unexpectedly can produce very inexpensive graphene, functionalized graphenes, and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol, functionalized graphenes, and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously.
    Type: Application
    Filed: June 1, 2012
    Publication date: June 6, 2013
    Applicant: NATIONAL NANOMATERIALS, INC.
    Inventor: Gary W. Beall
  • Publication number: 20120251953
    Abstract: Certain methanofullerene derivatives are described, having side chains with acid-labile protecting groups. The methanofullerene derivatives may find application as photoresist materials, and particularly as positive-tone photoresists.
    Type: Application
    Filed: November 18, 2010
    Publication date: October 4, 2012
    Inventors: Alex Robinson, Richard Palmer, Jon Andrew Preece
  • Publication number: 20120226068
    Abstract: The present invention provides a novel anhydride derivative of 2-(S)-(6-methoxy-2-naphtyl)-propanoic acid for preparing nitrooxyalkyl esters of 2-(S)-(6-methoxy-2-naphtyl)-propanoic acid with high purity to meet requirements of the industry.
    Type: Application
    Filed: February 8, 2012
    Publication date: September 6, 2012
    Applicant: EVERLIGHT USA, INC.
    Inventors: Hao-Cheng Yang, Chia-Chung Tsai, Chi-Hsiang Yao
  • Patent number: 8247158
    Abstract: The present invention refers to new organic molecules, derived from the class of polycarbocycle derivatives, and their application as components of photoresists, and in particular as components of photoresist compositions where no polymer is comprised as one of the photoresists components. In these photoresist formulations the new molecule(s) is/are the main component(s) (i.e. percentage higher than 50% w/w).
    Type: Grant
    Filed: September 18, 2006
    Date of Patent: August 21, 2012
    Inventors: Panagiotis Argitis, Evangelos Gogolides, Elias Couladouros, Dimitra Niakoula, Veroniki Vidali, Daman R. Gautam
  • Publication number: 20120156619
    Abstract: The present invention relates to an acrylate-based compound that includes an organic acid having two or more acrylate groups and one or more phenolic acid structures in one molecule, and a photosensitive composition including the same. It is possible to shorten a developing time in a photolithography process without damaging photosensitivity by using the photosensitive composition according to the present invention.
    Type: Application
    Filed: November 18, 2011
    Publication date: June 21, 2012
    Applicant: LG CHEM, LTD.
    Inventors: Keon Woo LEE, Sang Kyu KWAK, Changsoon LEE, Hyehyeon KIM
  • Publication number: 20120145959
    Abstract: A compound represented by the formula (1) is provided. In the formula (1), for example, R1 and R2 are alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 2 to 10 carbons; the ring A and the ring B are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are a single bond and Z3 is —CH2O— or —OCH2—; Y1 and Y2 are halogen, —CF3, —CHF2, —CH2F, —OCF3, —OCHF2 or —OCH2F; and m and n is 0, 1 or 2, p is 1 or 2, and the sum of m, n and p is 1, 2 or 3.
    Type: Application
    Filed: August 9, 2010
    Publication date: June 14, 2012
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventor: Tokifumi Masukawa
  • Publication number: 20120128588
    Abstract: Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent; R1 represents anyone selected from 11CH3, CH218F and CF218F; and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.
    Type: Application
    Filed: July 29, 2010
    Publication date: May 24, 2012
    Inventors: Misato Takashima, Miho Shukuri, Miki Goto, Hisashi Doi, Hirotaka Onoe, Masaaki Suzuki, Yasuyoshi Watanabe
  • Publication number: 20120129925
    Abstract: The present invention includes the use of pelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP 1 activity. This invention also provides novel terpene compounds capable of modulating SHIP 1 activity and methods of synthesis thereof.
    Type: Application
    Filed: August 19, 2011
    Publication date: May 24, 2012
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Raymond Andersen, David E. Williams, Alice Mui, Christopher Ong, Gerald Krystal, Lu Yang
  • Publication number: 20120116112
    Abstract: Process for the preparation of compounds of formula (IV): wherein R1-R6 are as defined in the specification. Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.
    Type: Application
    Filed: December 30, 2011
    Publication date: May 10, 2012
    Applicants: LES LABORATOIRES SERVIER, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Louis PEGLION, Olivier Baudoin, Nicolas Audic, Manon Chaumontet, Riccardo Piccardi
  • Patent number: 8119835
    Abstract: A method for preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid is disclosed based on “one pot” synthesis approach including a direct synthesis of boronic acid derivative from 2-(1-adamantyl)-4-bromoanisole and cycloboranes with a subsequent Suzuki-Miyaura coupling with 6-halonaphtenoates and basic hydrolysis of the reaction product in ethylene glycol or 1,2-propanediol.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: February 21, 2012
    Assignee: JSC Grindeks
    Inventors: Ivars Kalvinsh, Aleksandrs Chernobrovijs, Vyacheslav Tribulovich, Vladimir Labeish
  • Publication number: 20120029226
    Abstract: The present invention provides a method for the synthesis of optically pure ?-aryl propionic acid derivatives comprising subjecting the corresponding racemic ?-aryl propionic acid derivatives to high sheer or impact forces, such as grinding.
    Type: Application
    Filed: February 4, 2010
    Publication date: February 2, 2012
    Inventors: Bernardus Kaptein, Elias Vlieg, Willem Lieuwe Noorduin
  • Publication number: 20110301179
    Abstract: A compound (particularly useful for inhibiting cancer) according to formula I: or a pharmaceutically acceptable salt thereof, wherein: x is 0 or 1; R1-R6 are each independently H, —CN, —NO2, —NO, —OH, halogen, hydroxyalkyl, carboxyl, substituted carboxyl, aminocarbonyl, alkoxy, carbonyl or substituted carbonyl; R7 is H, alkyl, alkyl amino, aminoacyl, hydroxyacyl, heteroaryl, heterocycloalkyl, alkyl heteroaryl or alkyl heterocycloalkyl; R8 is H or alkyl; A is O or N; and Ar is an aryl, substituted aryl, heteroaryl, or substituted heteroaryl, provided that if R7 is H then Ar is aryl substituted with alkyl amino.
    Type: Application
    Filed: October 21, 2009
    Publication date: December 8, 2011
    Inventors: Xiangshu Xiao, Bingbing Li
  • Patent number: RE43372
    Abstract: Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: May 8, 2012
    Assignee: Duke University
    Inventors: Mitchell Anthony deLong, David Lindsey Soper, John August Wos, Biswanath De