Oxy In Acid Moiety Patents (Class 560/55)
  • Patent number: 10717697
    Abstract: The present invention relates to a method for preparing 1,3-cyclohexanedicarboxylic acid capable of exhibiting excellent activity, of enhancing the reaction efficiency and economic efficiency by using a catalyst having improved durability under the reaction conditions of high temperature and strong acid, of achieving excellent conversion rates by allowing most of reactants to participate in the reaction, and of obtaining products having high purity while minimizing by-products within a shorter period of time. The method for preparing 1,3-cyclohexanedicarboxylic acid may include: reducing isophthalic acid in the presence of a metal catalyst fixed to a silica support and containing a palladium (Pd) compound and a copper (Cu) compound in a weight ratio of 1:0.1 to 0.5.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: July 21, 2020
    Assignee: LOTTE CHEMICAL CORPORATION
    Inventors: Sung Min Kim, Mi Sun Cha, Seong Hwan Choi, Young Heon Choi, Sung Joon Park, Chan Yeong Yun, Young Jong Seo
  • Patent number: 10626080
    Abstract: It is provided a process for the preparation of bimatoprost, which comprises: a) reacting a compound of formula (III) with ethylamine in the presence of a suitable solvent; and b) deprotecting compound obtained in step a) to obtain bimatoprost, wherein R1 is selected from (C1-C16)alkyl, (C1C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(C1-C16)alkyl, aryl, (C1-C16)alkylaryl, allyl, —(CH2—CH2—O)n—CH3 wherein n=1, 2, 3 or 4, and —CH(O—CH2—CH2)2; R2 is selected from H, (C1-C16)alkyl, (C1-C16)haloalkyl, (C2-C16)alkenyl, (C2-C16)haloalkenyl, (C1-C16)alkoxy(CrC16)alkyl, aryl, (C1-C16)alkylaryl, allyl; or, alternatively, R1 and R2 taken together are selected from —CH2—CH2—CH2—, —CH2—CH2—, —O—CH2—CH2—, and —O—CH?CH—. There are also provided intermediates useful in such preparation process.
    Type: Grant
    Filed: April 18, 2017
    Date of Patent: April 21, 2020
    Assignee: GENTEC, S.A.
    Inventors: Luis Octavio Silva Guisasola, Joaquín Nebot Troyano, Jordi Ripoll Altadill
  • Patent number: 10278910
    Abstract: Compositions including a discontinuous oil phase homogeneously dispersed in a continuous water phase, the oil phase containing a sunscreen agent that includes a polymer composition containing a linear, ultraviolet radiation absorbing polyether, the linear, ultraviolet radiation absorbing polyether including a chemically bound UV-chromophore; and an oil-in water emulsifier component including an anionic oil-in-water emulsifier in an amount such that the composition includes about 0.5 percent by weight to about 3 percent by weight of the anionic oil-in-water emulsifier.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: May 7, 2019
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Susan Daly, Frank C. Sun
  • Patent number: 9254254
    Abstract: Compositions including a discontinuous oil phase homogeneously dispersed in a continuous water phase, the oil phase including a sunscreen agent that includes a linear, ultraviolet radiation absorbing polyether that comprises a chemically bound UV-chromophore; and an oil-in water emulsifier component including an anionic oil-in-water emulsifier and a nonionic oil-in-water emulsifier having an alcohol functional group, wherein the weight ratio of the anionic oil-in-water emulsifier to the nonionic oil-in-water emulsifier is about 12 or less and wherein the linear, ultraviolet radiation absorbing polyether is present in an amount effective to provide the composition with an SPF of about 10 or greater.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: February 9, 2016
    Assignee: Johnson & Johnson Consumer Inc.
    Inventor: Susan Daly
  • Patent number: 9255180
    Abstract: A polymer composition comprising a linear ultraviolet radiation absorbing polyether that comprises a chemically bound UV-chromophore.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: February 9, 2016
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Christopher G. Levins, Joseph F. Zavatsky, Aruna Nathan, Susan Daly
  • Patent number: 9248092
    Abstract: Compositions including a discontinuous oil phase homogeneously dispersed in a continuous water phase, the oil phase containing a sunscreen agent that includes a polymer composition containing a linear, ultraviolet radiation absorbing polyether, the linear, ultraviolet radiation absorbing polyether including a chemically bound UV-chromophore; and an oil-in water emulsifier component including an anionic oil-in-water emulsifier in an amount such that the composition includes about 0.5 percent by weight to about 3 percent by weight of the anionic oil-in-water emulsifier.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: February 2, 2016
    Assignee: Johnson & Johnson Consumer Inc.
    Inventor: Susan Daly
  • Patent number: 8921420
    Abstract: Method for preparing 3,5-dicaffeoylquinic acid and certain derivatives thereof, and use thereof in the preparation of plant-protection products. Method for combating aphids using 3,5-dicaffeoylquinic acid and certain derivatives thereof.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: December 30, 2014
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Jean-Luc Poessel, Marie-Hélène Collet, Yves Noel Elie Rahbe
  • Patent number: 8916723
    Abstract: A regio-selective and consecutive Michael-Claisen process has been developed for substituted cyclohexane-1,3-dione synthesis started from unsubstituted or substituted acetone and ?,?-unsaturated esters. Substituted cyclohexane-1,3-diones are the basic unit found in several natural products, bioactive alkaloids and acridine dione type heterocycles, polyphenols, and unnatural amino acid synthesis. Most of the potent herbicidal and pesticidal active molecules contain cyclohexane-1,3-dione derivatives. Such an important intermediate synthesis using a facile, atom economy and one-pot process is a demandable area in organic synthesis.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: December 23, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Pralay Das, Dharminder Sharma, Bikram Singh
  • Publication number: 20140350104
    Abstract: Provided are methods of reducing body fat in a subject, comprising locally (e.g., topically) administering one or more compounds of the Formula (I) and/or (V) or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, polymorph, tautomer, isotopically enriched derivative, or prodrug thereof, wherein X is —OR1 —SR2 or —NR3R4, and R1, R2, R3, R4, R5, R6, R7, R7?, Z, Y, n, y, and x, are as defined herein.
    Type: Application
    Filed: December 19, 2012
    Publication date: November 27, 2014
    Applicant: Topokine Therapeutics, Inc.
    Inventors: Murat V. Kalayoglu, Michael S. Singer
  • Patent number: 8865273
    Abstract: A photoalignment compound is represented by the following Chemical Formula 1, wherein “x” represents an integer in a range of 1 to 4, each of R1 and R2 represents —(CH2)n—, “n” represents an integer in a range of 1 to 6, at least one of the (—CH2-)s in R1 is replaceable with R3 represents —(CH2)mCH3, “m” represents an integer in a range of 1 to 12, each hydrogen atom of R3 is replaceable with F or Cl, R4 represents an amino group, aniline group, carboxy group, hydroxyl group, cyano group, alkylene group, or functional groups being represented by the following Chemical Formulas 2, 3, 4, or 5, each hydrogen atom of Chemical Formula 1 is replaceable with —O(CH2)kCH3, —(CH2)kCH3, F, or Cl, and “k” represents an integer in a range of 1 to 3, or 0.
    Type: Grant
    Filed: August 7, 2012
    Date of Patent: October 21, 2014
    Assignee: Samsung Display Co., Ltd.
    Inventors: Sung-Chan Jo, Weon-Eik Oii
  • Publication number: 20140213815
    Abstract: The present invention relates to a norbornene monomer, a polynorbornene derivative, a liquid crystal alignment film including the same, and a liquid crystal display device including the same. More particularly, the present invention relates to a norbornene monomer, a polynorbornene derivative, a liquid crystal alignment film including the same, and a liquid crystal display device including the same, which have an alignment property by photoreaction, excellent thermal stability and photoreactivity, the increased photo-reaction rate and reliability of the alignment film, thereby showing high manufacturing process efficiency.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 31, 2014
    Applicant: LG CHEM, LTD.
    Inventors: Dai-Seung CHOI, Heon KIM, Sung-Ho CHUN, Sung-Joon OH, Dong-Woo YOO, Yu-Chan KANG
  • Patent number: 8772329
    Abstract: The present invention relates to compounds from mycelium of Antrodia cinnamomea. The present invention also relates to a composition and a method for treating or prophylaxis of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: July 8, 2014
    Assignee: Simpson Biotech Co., Ltd.
    Inventors: Chia-Chin Sheu, Masao Hattori
  • Publication number: 20140159014
    Abstract: A crosslinkable compound comprising trifluorovinyl has a structure of Formula (I). A method for preparing the crosslinkable compound and a light emitting device prepared from the compound are also disclosed.
    Type: Application
    Filed: December 10, 2013
    Publication date: June 12, 2014
    Applicant: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Wenjun HOU
  • Publication number: 20140155632
    Abstract: The invention relates to a process for preparing aryl- and heteroarylacetic acids and derivatives thereof by reaction of aryl or heteroaryl halides with malonic diesters in the presence of a palladium catalyst, of one or more bases and optionally of a phase transfer catalyst. This process enables the preparation of a multitude of functionalized aryl- and heteroarylacetic acids and derivatives thereof, especially also the preparation of arylacetic acids with sterically demanding substituents.
    Type: Application
    Filed: February 27, 2012
    Publication date: June 5, 2014
    Inventors: Thomas Himmler, Lukas J. Goossen, Felix Rudolphi, Bingrui Song
  • Patent number: 8742143
    Abstract: A process for preparing a prostaglandin analogue comprising a step of converting a compound of formula (8?): to the prostaglandin analogue, wherein R3 represents hydrogen or a hydroxyl protecting group.
    Type: Grant
    Filed: March 27, 2013
    Date of Patent: June 3, 2014
    Assignee: Scinopharm Taiwan, Ltd.
    Inventors: Julian P. Henschke, Yuanlian Liu, Yung-Fa Chen, Dechao Meng, Ting Sun
  • Publication number: 20140120058
    Abstract: The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.
    Type: Application
    Filed: April 12, 2012
    Publication date: May 1, 2014
    Inventors: Michael Shane O'Shea, Florian Hans Maximillian Graichen, Russell John Tait, Andrew Craig Donohue, Sarah Man Yee Ng, Asha Marina D'Souza
  • Patent number: 8709281
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; and R3-R9 are as described in the disclosure. Also featured are liquid crystal compositions comprising a chiral dopant compound represented by any of Structure 2-4 as described in the disclosure.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: April 29, 2014
    Assignee: Kent State University
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Publication number: 20140107371
    Abstract: Disclosed are hierarchically porous carbon materials with a plurality of discreet nanoparticles dispersed on their carbon phase. The materials possess a continuous network of pores that spans the porous material, permitting the flow of fluids into and through the material. The porous materials can be used as heterogeneous catalysts.
    Type: Application
    Filed: October 16, 2013
    Publication date: April 17, 2014
    Applicant: Board of Trustees of The University of Alabama
    Inventors: Martin G. Bakker, Franchessa Maddox Sayler, Kevin Shaughnessy
  • Publication number: 20140107166
    Abstract: The present invention provides novel compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of a compound of the invention to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
    Type: Application
    Filed: February 13, 2012
    Publication date: April 17, 2014
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Ralph Mazitschek, James E. Bradner, Melissa Grachan Harman
  • Publication number: 20140100384
    Abstract: Provided is a process for making non-phthalate plasticizers, by acylating an aromatic compound with a succinic anhydride to form a keto-acid, and then esterifying the keto-acid with C4-C13 OXO-alcohols to form a plasticizer compound. The aromatic rings of the aromatic compound may also be optionally hydrogenated.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 10, 2014
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Jihad Mohammed Dakka, Edmund John Mozeleski, Lisa Saunders Baugh, Colle Karla Schall, Allen David Godwin, Diana S. Smirnova, Jorg Friedrich Wilhelm Weber, Stephen Zushma
  • Publication number: 20140031230
    Abstract: An object of the present invention is to provide an auxin biosynthesis inhibitor superior to L-AOPP. The object can be attained by a compound represented by general formula (I): wherein, R1 to R5 and X are the same as defined in the specification or a salt or solvate thereof.
    Type: Application
    Filed: February 28, 2012
    Publication date: January 30, 2014
    Inventors: Yukihisa Shimada, Ko Kikuzato, Megumi Narukawa, Tadao Asami, Kazuo Soeno
  • Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Patent number: 8633223
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: January 21, 2014
    Assignee: Yuhan Corporation
    Inventors: Chun-Ho Lee, Ja-Heouk Khoo, Kyoung-Chan Kwon, Hyun Ju
  • Patent number: 8613868
    Abstract: The present invention relates to compounds represented by the following Formula I, In Formula I, R1 and R2 are each independently selected from hydrogen, and optionally substituted hydrocarbyl, provided that at least one of R1 and R2 is selected from optionally substituted hydrocarbyl (e.g., tertiary butyl); n is 0, 1 or 2, and each R3 is independently selected from optionally substituted hydrocarbyl; L1 is a divalent linking group, such as a bond or —C(O)O—; each L2 independently represents a flexible segment, such as divalent linear or branched C1-C25 alkyl; each L3 independently represents a rigid segment including, for example, optionally substituted phenylen-1,4-diyl groups; t is from 1 to 4; m and p are each independently from 0 to 4 for each t, provided that the sum of m and p is at least 1 for each t; and E can be, for example, C5-C18 aryl.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: December 24, 2013
    Assignee: Transitions Optical, Inc
    Inventors: Xiao-Man Dai, Ruisong Xu, Meng He, Anil Kumar, Rachael L. Yoest, Chenguang Li
  • Publication number: 20130331556
    Abstract: A catalytic glycosylation method comprising: installing thioether to an anomeric carbon of a carbohydrate; and catalytically activating the thioether with a non-oxophilic Lewis acid. The thioether may comprise an anomerically stable thioether leaving group. The catalytic glycosylation method may further comprise: utilizing an acid-sensitive ester protecting group as permanent protecting group or using a reactivity-based one-pot glycosylation that employs a single-component catalyst to accelerate an oligosaccharide assembly process. A protecting group to mask hydroxyl functionalities in the production of oligosaccharides, natural products or any molecule having a hydroxyl group comprising an acid-labile ester protecting group.
    Type: Application
    Filed: June 6, 2013
    Publication date: December 12, 2013
    Inventor: Xinyu Liu
  • Publication number: 20130303798
    Abstract: A production process for substituted phenylacetic acids or ester analogues thereof is disclosed. In this process toluene or toluene substituted with various substituents, an alcohol, an oxidant and carbon monoxide are used as raw materials to obtain compounds comprising structure of phenylacetic acid ester or analogues thereof by catalysis of the complex catalyst formed from transition metal and ligand, and such compounds are hydrolyzed to obtain various substituted phenylacetic acid based compounds. This type of compounds and their derivatives serve as important fine chemicals used widely in the industries of pharmaceuticals, pesticides, perfume and the like.
    Type: Application
    Filed: December 20, 2012
    Publication date: November 14, 2013
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventor: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
  • Publication number: 20130281564
    Abstract: The present invention relates to novel photoactive polymer materials their use as orienting layer for liquid crystals, which are used for the production of non-structured and structured optical elements or electro-optical elements and multi-layer systems.
    Type: Application
    Filed: December 21, 2011
    Publication date: October 24, 2013
    Applicant: ROLIC AG
    Inventor: Hubert Seiberle
  • Patent number: 8552215
    Abstract: Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a carboxylic acid anhydride, or a carboxylic acid anhydride and a carboxylic acid. In particular, in the case where the solvent contains a carboxylic acid anhydride, but does not contain a carboxylic acid, as the carboxylic acid anhydride, a carboxylic acid anhydride containing a tertiary or quaternary carbon atom in the a-position is used. On the other hand, in the case where the solvent contains a carboxylic acid anhydride and a carboxylic acid, as the carboxylic acid, a carboxylic acid containing a tertiary or quaternary carbon atom in the a-position is used.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: October 8, 2013
    Assignee: Tokyo University of Science Educational Foundation Administrative Organization
    Inventors: Isamu Shiina, Kenya Nakata
  • Publication number: 20130259850
    Abstract: Uric acid in mammalian subjects is reduced and excretion of uric acid is increased by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; m+n is not more than 4; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, methyl or ethyl and R12 is hydrogen or methyl, or R6 is hydroxy and R12 is hydrogen, or R6 is O and R12 is absent, or R6 and R12 together are —CH2CH2—. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms.
    Type: Application
    Filed: May 9, 2013
    Publication date: October 3, 2013
    Applicant: WELLSTAT THERAPEUTICS CORPORATION
    Inventors: James Dennen O'NEIL, Michael K. BAMAT, Reid W. von BORSTEL, Shalini SHARMA, Ramachandran ARUDCHANDRAN
  • Publication number: 20130237599
    Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 12, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG, STANLEY CHI CHUNG CHIK
  • Publication number: 20130231478
    Abstract: The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.
    Type: Application
    Filed: July 29, 2011
    Publication date: September 5, 2013
    Inventors: Ziao Xu, Yuanhai Zhao, Degang Li, Xiaoxiang Li
  • Publication number: 20130217768
    Abstract: Processes for preparing water soluble and oil soluble antioxidant compositions extracted together from Labiatae herbs in a single extraction using an alcohol and water solvent, followed by a simple, yet effective purification step that allows the separation of the water soluble antioxidative fractions containing mainly rosmarinic acid from antioxidative fractions containing mainly carnosic acid and carnosol, without cumbersome acid/base partitioning steps.
    Type: Application
    Filed: October 25, 2011
    Publication date: August 22, 2013
    Applicant: KALAMAZOO HOLDINGS, INC.
    Inventors: Roger Nahas, Elizabeth Barren, Gregory S. Reynhout
  • Publication number: 20130217901
    Abstract: The invention relates to a method of producing optically active 4-chloro-3-hydroxybutanal compound (2) by reacting chloroacetaldehyde with aldehyde compound (1) in the presence of optically active pyrrolidine compound (5). wherein each symbol is as defined in the specification.
    Type: Application
    Filed: October 19, 2011
    Publication date: August 22, 2013
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Yujiro Hayashi
  • Publication number: 20130211128
    Abstract: A process for preparing a prostaglandin analogue comprising a step of converting a compound of formula (8?): to the prostaglandin analogue, wherein R3 represents hydrogen or a hydroxyl protecting group.
    Type: Application
    Filed: March 27, 2013
    Publication date: August 15, 2013
    Applicant: SCINOPHARM TAIWAN LTD.
    Inventors: Julian P. HENSCHKE, Yuanlian LIU, Yung-Fa CHEN, Dechao MENG, Ting SUN
  • Patent number: 8487106
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefore. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: July 16, 2013
    Assignee: Yuhan Corporation
    Inventors: Chun-Ho Lee, Ja-Heouk Khoo, Kyoung-Chan Kwon, Hyun Ju
  • Patent number: 8481593
    Abstract: The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: July 9, 2013
    Assignees: BASF Beauty Care Solutions S.A.S., Universite Joseph Fourier-Grenoble 1
    Inventors: Sabrina Okombi, Delphine Rival, Ahcene Boumendjel, Anne-Marie Mariotte, Eric Perrier
  • Patent number: 8454857
    Abstract: A polymerizable liquid crystal compound shown by the following formula, a polymerizable liquid crystal composition that includes the polymerizable liquid crystal compound and a chiral compound polymerizable with the polymerizable liquid crystal compound, a liquid crystalline polymer obtained by polymerizing the polymerizable liquid crystal compound or the polymerizable liquid crystal composition, and an optically anisotropic article that includes the liquid crystalline polymer, are disclosed.
    Type: Grant
    Filed: June 17, 2009
    Date of Patent: June 4, 2013
    Assignee: Zeon Corporation
    Inventors: Kei Sakamoto, Yasushi Nakano
  • Publication number: 20130129646
    Abstract: The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods.
    Type: Application
    Filed: May 25, 2010
    Publication date: May 23, 2013
    Inventors: Gabriele Vielhaber, Heiko Oertling, Karin Schaper, Claudia Gömann, Rahim Brodhage
  • Publication number: 20130116466
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Application
    Filed: December 26, 2012
    Publication date: May 9, 2013
    Applicant: YUHAN CORPORATION
    Inventor: YUHAN CORPORATION
  • Publication number: 20130079545
    Abstract: A regio-selective and consecutive Michael-Claisen process has been developed for substituted cyclohexane-1,3-dione synthesis started from unsubstituted or substituted acetone and ?,?-unsaturated esters. Substituted cyclohexane-1,3-diones are the basic unit found in several natural products, bioactive alkaloids and acridine dione type heterocycles, polyphenols, and unnatural amino acid synthesis. Most of the potent herbicidal and pesticidal active molecules contain cyclohexane-1,3-dione derivatives. Such an important intermediate synthesis using a facile, atom economy and one-pot process is a demandable area in organic synthesis.
    Type: Application
    Filed: March 18, 2011
    Publication date: March 28, 2013
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Pralay Das, Dharminder Sharma, Bikram Singh
  • Publication number: 20130053598
    Abstract: The invention relates to a method for producing a cross-coupling product of a benzenoid dizonium salt according to the general formula (I), wherein the groups R1, R2, R3, R4, and R5 represent hydrogen, halogen, an alkyl, alkenyl, aryl, alkoxy, aryloxy, nitro, cyano, hydroxy, acetyl, and/or diazo groups independently of each, and X represents BF4, Cl, F, SO3CH3, CO2CH3, PF6, ClO2CH3, or CIO4, comprising the following steps: (a) providing a benzenoid amide, which with the exception of the diazo function has the same substituents R1, R2, R3, R4, and R5 as the benzenoid diazonium salt of the general formula (I), and hydrolytically cleaving the amide to form an amine or providing a corresponding amine, (b) diazotizing the amine thus obtained or provided with a nitrite, and (c) subsequently reacting the benzenoid diazonium salt with a coupling partner in the presence of a catalyst to form a cross-coupling product, wherein the coupling parter is represented by the general formula (II), R6, R7, and R8 are the same or
    Type: Application
    Filed: April 22, 2010
    Publication date: February 28, 2013
    Applicant: ZYLUM BETEILIGUNGSGESELLSCHAFT MBH & CO. PATENTE II KG
    Inventors: Nicolas Boege, Andreas Kreipl, Bernd Schmidt, Frank Hoelter, René Berger
  • Publication number: 20130035431
    Abstract: Provided are compounds of the formula: wherein m=0-3 and n=0-3, and R1 represents CxH2x wherein x=0 to 4 or cyclohexane; R2 represents H, a C1-C6 alkyl group at any of the ortho-, meta- or para-positions, a residue including heteroatoms chosen from O, N, and S, or mixtures thereof; and R3 and R4 represent hydrocarbon residues of OXO-C5-C9 alcohols which are different isomers of equal carbon number or different in carbon number. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.
    Type: Application
    Filed: August 5, 2011
    Publication date: February 7, 2013
    Applicant: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY
    Inventors: Jihad Mohammed Dakka, Stephen Zushma, Christine A. Costello, Edmund John Mozeleski, Diana S. Smirnova, Allen David Godwin, Pierre J. Osterrieth, Jörg Friedrich Wilhelm Weber, Paul Hamden Daniels, Thomas M. Larson, Catherine A. Faler
  • Patent number: 8367704
    Abstract: The present invention relates to a process for preparing 2-methyl-2?-phenylpropionic acid derivatives showing antihistamine activity in more simplified way, intermediate compounds and their preparation processes used therefor. According to the present invention, pharmaceutically useful 2-methyl-2?-phenylpropionic acid derivatives can be prepared with high yield and purity on industrial scale.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: February 5, 2013
    Assignee: Yuhan Corporation
    Inventors: Chun-Ho Lee, Ja-Heouk Khoo, Kyoung-Chan Kwon, Hyun Ju
  • Publication number: 20130004840
    Abstract: A non-aqueous electrolyte additive for a lithium secondary battery, a non-aqueous electrolyte for a lithium secondary battery, and a lithium secondary battery, the additive including a bidentate phosphorus compound represented by the following Chemical Formula 1.
    Type: Application
    Filed: February 1, 2012
    Publication date: January 3, 2013
    Inventors: Jung-Yi YU, Woo-Cheol Shin, Sang-Il Han, Mi-Hyun Lee, Tae-Hyun Bae
  • Publication number: 20120301628
    Abstract: A photoalignment compound is represented by the following Chemical Formula 1, wherein “x” represents an integer in a range of 1 to 4, each of R1 and R2 represents —(CH2)n—, “n” represents an integer in a range of 1 to 6, at least one of the (—CH2-)s in R1 is replaceable with R3 represents —(CH2)mCH3, “m” represents an integer in a range of 1 to 12, each hydrogen atom of R3 is replaceable with F or Cl, R4 represents an amino group, aniline group, carboxy group, hydroxyl group, cyano group, alkylene group, or functional groups being represented by the following Chemical Formulas 2, 3, 4, or 5, each hydrogen atom of Chemical Formula 1 is replaceable with —O(CH2)kCH3, —(CH2)kCH3, F, or Cl, and “k” represents an integer in a range of 1 to 3, or 0.
    Type: Application
    Filed: August 7, 2012
    Publication date: November 29, 2012
    Inventors: Sung-Chan Jo, Weon-Eik Oii
  • Publication number: 20120296074
    Abstract: The problem of the present invention is provision of a method of producing an n+p-mer oligonucleotide efficiently in a high yield, which includes use of, as a starting material, an n-mer oligonucleotide wherein the 3?-terminal hydroxyl group is protected, and the 5?-terminal hydroxyl group is protected by a temporary protecting group, and continuously performing, in a solution, (1) a deprotection step of the 5?-terminal hydroxyl group, (2) a 5?-terminal elongation step by the addition of a p-mer oligonucleotide wherein the 3?-position is phosphoramidited, and (3) an oxidation step or a sulfurization step of a phosphite triester moiety. It has been found that the above-mentioned problem can be solved by adding a particular cation scavenger during the deprotection step, applying a neutralization treatment after completion of the deprotection reaction, and using a particular oxidizing agent or sulfurizing agent in the oxidation step or sulfurization step.
    Type: Application
    Filed: May 17, 2012
    Publication date: November 22, 2012
    Applicant: AJINOMOTO CO., INC.
    Inventors: Kunihiro HIRAI, Satoshi KATAYAMA
  • Publication number: 20120289695
    Abstract: Methods of producing organic materials, and in particular methods of producing petroleum materials and organic compounds such as aromatic acids, phenols, and aliphatic poly-carboxylic acids using an oxidative hydrothermal dissolution (OHD) process are disclosed.
    Type: Application
    Filed: June 4, 2012
    Publication date: November 15, 2012
    Applicant: SOUTHERN ILLINOIS UNIVERSITY CARBONDALE
    Inventors: Kenneth B. Anderson, John C. Crelling, William W. Huggett, Derek M. Perry
  • Publication number: 20120282201
    Abstract: The invention relates to novel polyglycerol based UV-filters as well as to topical compositions comprising such novel polyglycerol based UV-filters. Furthermore, the invention relates to the use of such novel polyglycerol based UV-filters to enhance the solubility of butyl methoxydibenzoylmethane or bis-ethylhexyloxyphenol methoxyphenyl triazine in cosmetic oils.
    Type: Application
    Filed: December 8, 2010
    Publication date: November 8, 2012
    Inventor: Alexander Schlifke-Poschalko
  • Patent number: 8293134
    Abstract: An optically anisotropic material having a good durability against light is provided. Further, an optical element having a good durability against light and an optical information writing/reading device employing such an element are provided. The optically anisotropic material is obtainable by polymerizing a polymerizable liquid crystal composition containing at least 5 mol % of at least one type of polymerizable compound represented by a general formula CH2?CR1—COO—K-Cy-Cy-L-OCO—CR2?CH2. A phase difference plate 4 produced by employing the optically anisotropic material has a good durability against light, and accordingly, the phase difference plate 4 can realize an optical heat device suitable for large capacity writing/reading by employing a blue laser as a light source 1.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: October 23, 2012
    Assignee: Asahi Glass Company, Limited
    Inventors: Satoshi Okada, Hiroshi Kumai, Makota Hasegawa
  • Patent number: 8262932
    Abstract: A polymerizable liquid crystal compound represented by formula (I) is disclosed. R0 and R1 represent a hydrogen atom, or a C1-4 alkyl group, provided that at least one of R0 and R1 represent a C1-4 alkyl group; A0, A1, B0 and B1 represent a single bond, or a divalent linking group having a cyclic structure; X0, X1, Y0 and Y1 represent a single bond, —O—, —S—, —OCO—, —COO—, —OCOO—, —NR2CO—, —CONR2—, —OCONR2—, —NR2COO—, —NR2CONR2—, —C?N— or —N?C—; Q0 and Q1 a single bond or a divalent aliphatic group; Z0 and Z1 represent a hydrogen atom, cyano, halogen atom or polymerizable group; and n and m each independently represent an integer of from 0 to 2.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: September 11, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Shunya Katoh, Mitsuyoshi Ichihashi