Rings Bonded Directly To Each Other In Acid Moiety Patents (Class 560/59)
  • Patent number: 4073936
    Abstract: The compounds are 4-aryl substituted buta-2,3-dienoic acids and esters thereof which may also be lower alkyl-substituted at any of the 2- and 4- positions, e.g., 4-(p-methoxyphenyl)-2-methyl-buta-2,3-dienoic acid. The compounds are useful as pharmaceuticals, e.g., as antiinflammatory agents and hypolipidemic agents.
    Type: Grant
    Filed: November 17, 1976
    Date of Patent: February 14, 1978
    Assignee: Sandoz, Inc.
    Inventors: Eugene E. Galantay, Faizulla G. Kathawala
  • Patent number: 4072754
    Abstract: Hydratropic acid derivatives of the formula ##STR1## wherein R.sub.1 is H, alkyl of 1-4 carbon atoms, 2-acetamidoethyl, 1-methyl-4-piperidyl, or 2,3-dihydroxypropyl, and R.sub.2 is Hal, phenyl, 4-Hal-phenyl, 4-Hal-phenoxy, 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindolino, 1,2,3,4-tetrahydroquinolino, 1,2,3,4-tetrahydro-4-quinolyl or 1-methyl-1,2,3,4-tetrahydro-4-quinolyl, Hal being F, Cl, or Br, and the physiologically acceptable salts thereof, which possess cholesterol and triglyceride serum-level-lowering activity, can be prepared by reacting a phenol of the formula ##STR2## with a compound of the formula X--C(CH.sub.3)(C.sub. 6 H.sub.5)--COOR.sub.1 wherein X represents Cl, Br, I, OH, or esterified OH.
    Type: Grant
    Filed: November 25, 1974
    Date of Patent: February 7, 1978
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Zdenek Simane, Herbert Nowak, Detlev Kayser
  • Patent number: 4069344
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 represents cyclohexyl, cyclohexyloxy or the ##STR2## BEING BONDED TO THE PHENYL NUCLEUS, R.sub.2 represents hydrogen, C.sub.1 -C.sub.3 -alkyl, R.sub.3 represents --COOH, (C.sub.1 -C.sub.5 -alkoxy)carbonyl, (C.sub.3 -C.sub.5 -alkenyloxy)carbonyl, (C.sub.3 -C.sub.5 -alkinyloxy)carbonyl, cyclohexyloxycarbonyl, phenoxycarbonyl, (C.sub.3 -C.sub.5 -haloalkenyloxy)carbonyl, the cyano group, a carbamoyl group which is mono- or disubstituted by C.sub.1 -C.sub.5 -alkyl, C.sub.3 -C.sub.5 -alkenyl or C.sub.3 -C.sub.5 -alkinyl, it being possible for the substituents of the carbamoyl group together with the nitrogen atom to which they are bonded to form a saturated 5- or 6-membered heterocyclic ring which can contain in addition an oxygen, a sulphur, or a further nitrogen atom, R.sub.4 represents hydrogen, methyl, or ethyl, R.sub.5 represents C.sub.1 -C.sub.3 -alkyl, formyl, or acetyl, R.sub.6 represents hydrogen or C.sub.1 -C.sub.3 -alkyl, R.sub.
    Type: Grant
    Filed: March 15, 1976
    Date of Patent: January 17, 1978
    Assignee: CIBA-GEIGY Corporation
    Inventor: Friedrich Karrer
  • Patent number: 4065489
    Abstract: Biphenyl esters of the formula ##STR1## wherein X is --CO--O-- or --O--CO-- and R.sub.1 and R.sub.2 each are alkyl or alkoxy of 1 - 8 carbon atoms, enlarge significantly the temperature range of the nematic phase of liquid-crystalline compositions without adversely affecting other properties.
    Type: Grant
    Filed: October 21, 1975
    Date of Patent: December 27, 1977
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Rolf Steinstrasser, Fernando Del Pino
  • Patent number: 4057647
    Abstract: Compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and are F, Cl or Br;Q is --CH(CH.sub.3)-CH.sub.2 --, --C(OH) (CH.sub.3)-CH.sub.2 -- or --C(CH.sub.3) .dbd.CH--;Y is COOH, COOR.sup.3, CH.sub.2 OH or CH.sub.2 OAc;n is 0 or 1;R.sup.3 is alkyl or aryl of up to 8 carbon atoms or C.sub.6 H.sub.4 NHCOCH.sub.3 ; andAc is acyl of 1-8 carbon atoms;And physiologically acceptable salts thereof, are anti-inflammatory agents, which can be made from compounds of the formula Z -- X, wherein Z is ##STR2## AND X can be converted to --Q-Y.
    Type: Grant
    Filed: June 14, 1976
    Date of Patent: November 8, 1977
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Joachim Gante, Hans-Adolf Kurmeier, Dieter Orth, Erich Schacht, Albrecht Wild
  • Patent number: 4055595
    Abstract: Derivatives of 2-hydroxy-3,3,3-trifluoro-2-(alkyl or trifluoromethyl)propionic acid bearing a phenyl or naphthyl group linked to the 2-hydroxy group either directly or via an intermediate methylene group. The compounds reduce the concentrations of cholesterol, total esterified fatty acids or fibrinogen in the blood plasma of test animals and some compounds show anti-arthritic properties.
    Type: Grant
    Filed: November 10, 1975
    Date of Patent: October 25, 1977
    Assignee: Imperial Chemical Industries Limited
    Inventors: David Bryan Haydock, Thomas Patrick Cunningham Mulholland, Jeffrey Meyrick Thorp
  • Patent number: 4051104
    Abstract: Benzoyloxybenzoates having the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are lower alkyl or cycloalkyl,X is oxygen or sulfur, andR.sup.5 is alkyl, aryl, alkaryl or hydrogenAre useful as stabilizers of organic materials such as polyolefins.
    Type: Grant
    Filed: March 28, 1975
    Date of Patent: September 27, 1977
    Assignee: Ciba-Geigy Corporation
    Inventors: John D. Spivack, John J. Luzzi
  • Patent number: 4049823
    Abstract: Phenylbutanol derivatives of the formula Z--C(CH.sub.3) (OH)--CH.sub.2 --Y wherein Z is 4-biphenyl or 4-phenoxyphenyl wherein the phenoxy group is unsubstituted or substituted by F, Cl or Br and Y is COOR.sup.2 or CH.sub.2 OR.sup.3 wherein R.sup.2 is H or alkyl of 1 to 6 carbon atoms and R.sup.3 is H or alkanoyl of 1 to 6 carbon atoms, and their physiologically acceptable salts, possess anti-inflammatory activity and are produced by (a) treating with a solvolyzing agent a compound of the formula Z--C(CH.sub.3) (OH)--CH.sub.2 --W or Z--CX(CH.sub.3)--CH.sub.
    Type: Grant
    Filed: February 25, 1975
    Date of Patent: September 20, 1977
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Erich Schacht, Werner Mehrhof, Albrecht Wild, Joachim Gante, Hans-Adolf Kurmeier
  • Patent number: 4048147
    Abstract: A novel compound represented by the formula, ##STR1## WHEREIN R is a hydrogen or an alkyl group having 1 to 3 carbon atoms, said four R's being the same or different; R.sup.1 is hydrogen, an alkali metal, an ammonium group, a mono-to tetra-hydric aliphatic alcohol moiety having 1 to 12 carbon atoms, or an organic amine residue; n is an integer of 1 to 4; and R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are independently hydrogen or alkyl groups having 1 to 6 carbon atoms or R.sup.2 and R.sup.3 may form a ring when taken together. Said novel compound has properties similar to those of natural rosin or a disproportionated rosin, and is useful as a vehicle for coating compositions and printing inks, as an emulsifier for emulsion polymerization, and as a sizing agent.
    Type: Grant
    Filed: November 26, 1975
    Date of Patent: September 13, 1977
    Assignee: Japan Synthetic Rubber Co., Ltd.
    Inventors: Masatoshi Arakawa, Ryotaro Ohno, Katuhiro Ishikawa, Noboru Yamahara, Hisashi Matsui