Phenolic Hydroxy Or Metallate Patents (Class 560/75)
  • Patent number: 9962421
    Abstract: A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: May 8, 2018
    Assignee: Malaysian Palm Oil Board
    Inventors: T. G. Sambandan, ChoKyun Rha, Anthony J. Sinskey, Ravigadevi Sambanthamurthi, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri Wahid
  • Patent number: 9567284
    Abstract: To provide hexaester of bispentaerythritol monoformal, which is a mixed ester of bispentaerythritol monoformal represented by the following formula (I), and carboxylic acids: wherein the carboxylic acids comprise C9 branched aliphatic monocarboxylic acid, and any one of carboxylic acids selected from C4 to C8 aliphatic monocarboxylic acids. The hexaester is used as one component of a refrigerant oil composition, and gives excellent characteristics, such as oxidation stability, lubricity, and low temperature properties, to a refrigerant oil composition.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: February 14, 2017
    Assignee: KH NEOCHEM CO., LTD.
    Inventors: Shingo Nakayama, Takuya Nishimura, Toshihiro Inayama
  • Patent number: 9365484
    Abstract: Provided is hexaester of bispentaerythritol monoformal, which comprises the bispentaerythritol monoformal represented by the following formula (I), and any one of carboxylic acids selected from C8 and C9 branched aliphatic monocarboxylic acids: The hexaester has well-balanced excellent characteristics, such as low temperature properties and oxidation stability, and is used for industrial lubricating oil, such as a refrigerant oil composition.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: June 14, 2016
    Assignee: KH NEOCHEM CO., LTD.
    Inventors: Shingo Nakayama, Takuya Nishimura, Toshihiro Inayama
  • Patent number: 9023921
    Abstract: A method for inhibiting the crystal growth rate of an amide compound present in a molten polyolefin-based resin and a method for producing a polyolefin-based resin molded article are provided. A phenol compound is incorporated into an amide compound-containing polyolefin-based resin such that a weight ratio, amide compound:phenol compound, is 60:40 to 10:90.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: May 5, 2015
    Assignee: New Japan Chemical Co., Ltd.
    Inventors: Reira Ikoma, Shohei Iwasaki, Yohei Uchiyama
  • Patent number: 9012230
    Abstract: The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: April 21, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Sehoon Kim, Ick Chan Kwon, Jai Kyeong Kim, Chang-Keun Lim, Jeongyun Heo
  • Publication number: 20150056367
    Abstract: The present invention, which enables to align a liquid crystal molecule, when no voltage is applied thereto, and also to control pretilt angle of the liquid crystal molecule, relates to a composition for a liquid crystal alignment film comprising components represented by the following (A) to (D): (A) a meta-phenylene diamine derivative represented by the general formula [1]; (B) a meta-phenylene diamine derivative represented by the general formula [2]; (C) a para-arylene diamine represented by the general formula [3]; (D) a tetracarboxylic acid represented by the general formula [4] or a tetracarboxylic acid anhydride represented by the general formula [4?]; (wherein R1 represents an alkyl group having 1 to 6 carbon atoms or the like, R2 represents an alkyl group having 8 to 20 carbon atoms or the like, t moieties of Ra represent an alkyl group having 1 to 3 carbon atoms or the like, n represents an integer of 1 to 3, t represents an integer of 0 to 4, T represents an oxygen atom or the like, Y repre
    Type: Application
    Filed: March 13, 2013
    Publication date: February 26, 2015
    Inventors: Yoshihiro Hosaka, Michihiko Sato, Mo Wu
  • Publication number: 20150025247
    Abstract: Esters of O-substituted hydroxy carboxylic acids are provided having Formula 1, or 2, or both Formulas 1 and 2: wherein R and R1 are independently selected from the group consisting of substituted and unsubstituted, branched- and straight-chain, saturated, unsaturated, and polyunsaturated C1-C22 alkyl, substituted and unsubstituted C3-C8 cycloalkyl, substituted and unsubstituted C6-C20 carbocyclic aryl, and substituted and unsubstituted C4-C20 heterocyclic; wherein the heteroatoms are selected from sulfur, nitrogen, and oxygen; and wherein n is 1-6. Process of producing esters of O-substituted hydroxy carboxylic acids are also provided.
    Type: Application
    Filed: July 30, 2014
    Publication date: January 22, 2015
    Inventors: Liu DENG, Neil Warren BOAZ, Sabine DELAIRE
  • Publication number: 20150011755
    Abstract: The present application relates to amine salts of prostaglandin analogs and their uses for the preparation of substantially pure prostaglandin analogs. Specific embodiments relate to amine salts of tafluprost and their uses for the preparation of substantially pure tafluprost.
    Type: Application
    Filed: February 6, 2013
    Publication date: January 8, 2015
    Applicant: DR. REDDYS LABORATORIES LIMITED
    Inventor: Mark P Jackson
  • Patent number: 8907117
    Abstract: Synthetic dicinnamate compounds and their analogs are disclosed that exhibit anti-tumor activity and/or an anti-inflammatory activity, and have beneficial activity principally in destroying cancer cells. Furthermore, methods for the extraction of the extracts are disclosed.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: December 9, 2014
    Inventors: Henry Lowe, Joseph L. Bryant
  • Publication number: 20140343299
    Abstract: The invention relates to a process for the preparation of travoprost of formula (I), comprising that, the compound of formula (II), is stereo selectively reduced, the resulting compound of formula (III), is if desired crystallized, the lactone group of the compound of formula (III) is reduced, the p-phenyl-benzoyl protecting group of the thus obtained compound of formula (IV), is removed, the resulting triol of formula (V), is, if desired after crystallization, transformed by Wittig reaction into the acid of formula (VI), which is then esterified.
    Type: Application
    Filed: December 10, 2012
    Publication date: November 20, 2014
    Inventors: Zsuzsanna Kardos, Tibor Kiss, István Lászlofi, Irén Hortobágyi, Zoltán Bischof, Ádám Bódis, Gábor Havasi
  • Patent number: 8853393
    Abstract: The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: October 7, 2014
    Assignee: Anhui New Star Pharmaceutical Development Co., Ltd.
    Inventors: Ziao Xu, Yuanhai Zhao, Degang Li, Xiaoxiang Li
  • Publication number: 20140296544
    Abstract: The present invention provides a method for converting an aromatic hydrocarbon to a phenol by providing an aromatic hydrocarbon comprising one or more aromatic C—H bonds and one or more activated C—H bonds in a solvent; adding a phthaloyl peroxide to the solvent; converting the phthaloyl peroxide to a di-radical; contacting the di-radical with the one or more aromatic C—H bonds; oxidizing selectively one of the one or more aromatic C—H bonds in preference to the one or more activated C—H bonds; adding a hydroxyl group to the one of the one or more aromatic C—H bonds to form one or more phenols; and purifying the one or more phenols.
    Type: Application
    Filed: August 14, 2013
    Publication date: October 2, 2014
    Inventors: Dionicio Siegel, Andrew M. Camelio, Anders Eliasen, Trevor C. Johnson, Abram Axelrod, Changxia Yuan
  • Patent number: 8846292
    Abstract: A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with good shape and a method of forming a resist pattern and novel compositions for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Radiation-sensitive composition containing a solvent and a cyclic compound having, e.g., a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups, and a cyclic compound for use in the radiation-sensitive composition.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: September 30, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Dai Oguro
  • Publication number: 20140255450
    Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
    Type: Application
    Filed: February 18, 2013
    Publication date: September 11, 2014
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SY LAU, LAI HUNG CINDY YANG, CHI CHUNG STANLEY CHIK, CHUN BONG JAMES LI
  • Patent number: 8829192
    Abstract: Described is the use of specific merocyanine derivatives for protecting body-care and household products from photolytic and oxidative degradation. These compounds perform outstanding UV absorber properties.
    Type: Grant
    Filed: July 19, 2006
    Date of Patent: September 9, 2014
    Assignee: BASF SE
    Inventors: Barbara Wagner, Oliver Reich
  • Publication number: 20140249199
    Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a compound of formula (I), and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula (I) to a subject in need thereof.
    Type: Application
    Filed: July 19, 2012
    Publication date: September 4, 2014
    Applicants: HEALTH RESEARCH, INC., EMORY UNIVERSITY
    Inventors: Huw M. L. Davies, Spandan Chennamadhavuni, Andrei Bakin
  • Patent number: 8802892
    Abstract: The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R?]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: August 12, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20140208450
    Abstract: A new and distinct cultivar of Mentha spicata L. named KI-MsEM0042 and characterized by elevated levels of rosmarinic acid and vigorous growth.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 24, 2014
    Applicant: Kemin Industries, Inc.
    Inventors: Brindha Narasimhamoorthy, John A. Greaves, Sarah Wildgen, Rachel Barkley, Susan Ruden
  • Publication number: 20140196163
    Abstract: A new and distinct cultivar of Mentha spicata L. named KI-MsEM0110 and characterized by elevated levels of rosmarinic acid and vigorous growth.
    Type: Application
    Filed: March 10, 2014
    Publication date: July 10, 2014
    Applicant: Kemin Industries, Inc.
    Inventors: John A. Greaves, Brindha Narasimhamoorthy, Sarah Wildgen, Rachel Barkley, Susan Ruden
  • Publication number: 20140187617
    Abstract: Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
    Type: Application
    Filed: December 23, 2013
    Publication date: July 3, 2014
    Applicant: AERIE PHARMACEUTICALS, INC.
    Inventors: Mitchell A. deLong, Jill Marie Sturdivant, Susan M. Royalty
  • Patent number: 8674131
    Abstract: The dehydrated alkali metal salts of carboxylic acid are dissolved in the alcohol such as methanol or ethanol or butanol to make their solution in corresponding alcohol. The solution alcohol is further treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature such as 150 to 200° C. The carboxylic acid gets converted into corresponding alkyl ester and calcium carbonate or sodium carbonate or potassium carbonate as the byproduct. Calcium lactate or sodium lactate or sodium acetate or sodium benzoate or sodium salicylate as alkali metal salt solution prepared in methanol or ethanol or butanol when treated with carbon dioxide under pressure or at atmospheric pressure at elevated temperature gets converted to methyl lactate or ethyl lactate or methyl acetate or methyl benzoate or methyl salicylate as product.
    Type: Grant
    Filed: September 6, 2010
    Date of Patent: March 18, 2014
    Assignee: Council of Scientific and Industrial Research
    Inventors: Prashant Purushottam Barve, Bhaskar Dattatraya Kulkarni, Milind Yashwant Gupte, Sanjay Narayan Nene, Ravindra William Shinde
  • Publication number: 20130345445
    Abstract: The present invention relates to a method of reducing a C—O bond to the corresponding C—H bond in a substrate which could be a benzylic alcohol, allylic alcohol, ester, or ether or an ether bond beta to a hydroxyl group or alpha to a carbonyl group.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 26, 2013
    Applicant: KAT2BIZ AB
    Inventors: Joseph Samec, Anna Lundstedt, Supaporn Sawadjoon
  • Publication number: 20130338160
    Abstract: The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.
    Type: Application
    Filed: June 18, 2013
    Publication date: December 19, 2013
    Inventors: Charles SHIH, Qian Shi, Hui-kang Wang
  • Publication number: 20130303611
    Abstract: Disclosed is the use of the compounds represented by formula (I) in the preparation of a medicament against tumor angiogenesis, wherein R1 and R2 are each independently C1-C8 alkylidene group or C2-C8 alkenylidene group; A1 and A2 are each independently aryl, isoaryl, or aryl or isoaryl optionally substituted by halogen, —CN, —NO2, —OH, —SH, —OR3, —SR3, —R3, —R3—OR4, —C(O)R3, —S(O)R3, —S(O)2R3, —NR4R5, —C(O)OR3, —C(O)NR4R5, —O(O)CR4, —S(O)CR4 or —NR4(O)CR5, wherein R3 is C1-C4 alkyl, R4 and R5 are each independently hydrogen, C1-C4 alkyl, aryl or substituted aryl; and X and Y are each independently oxygen; and the compound of formula (I) does not include phenethyl caffeate.
    Type: Application
    Filed: December 8, 2011
    Publication date: November 14, 2013
    Inventors: Junyi Liu, Yansheng Du, Jirun Peng, Zhizhong Ma
  • Publication number: 20130253218
    Abstract: The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity by removing the protecting group of a protected prostaglandin E (PGE) derivative obtained from conjugate addition and then stereoselectively reducing the ketone group on the cyclopentanone ring of the PGE derivative.
    Type: Application
    Filed: May 23, 2013
    Publication date: September 26, 2013
    Applicant: YONSUNG FINE CHEMICAL CO., LTD.
    Inventors: Changyoung OH, Kee Young LEE, Yong Hyun KIM, Jae Eun JOO
  • Publication number: 20130237599
    Abstract: The present invention provides compounds, and compositions comprising these compounds, which have immunomodulatory activity and/or anti-inflammatory activity.
    Type: Application
    Filed: March 8, 2013
    Publication date: September 12, 2013
    Applicants: VERSITECH LIMITED, PURAPHARM COMPANY LIMITED
    Inventors: ALLAN SIK YIN LAU, LAI HUNG CINDY YANG, STANLEY CHI CHUNG CHIK
  • Publication number: 20130231478
    Abstract: The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.
    Type: Application
    Filed: July 29, 2011
    Publication date: September 5, 2013
    Inventors: Ziao Xu, Yuanhai Zhao, Degang Li, Xiaoxiang Li
  • Publication number: 20130210913
    Abstract: Synthetic dicinnamate compounds and their analogues are disclosed that exhibit anti-tumor activity and/or an anti-inflammatory activity, and have beneficial activity principally in destroying cancer cells. Furthermore, methods for the extraction of the extracts are disclosed.
    Type: Application
    Filed: September 10, 2012
    Publication date: August 15, 2013
    Inventors: Henry Lowe, Joseph L. Bryant
  • Publication number: 20130203713
    Abstract: The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.
    Type: Application
    Filed: February 2, 2013
    Publication date: August 8, 2013
    Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventor: Rutgers, The State University of New Jersey
  • Publication number: 20130203712
    Abstract: In one aspect, the invention relates methods for inhibiting or preventing muscle atrophy or increasing muscle mass by providing to a subject in need thereof an effective amount of ursolic acid, a derivative thereof, or an analog of the ursane scaffold. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: May 19, 2011
    Publication date: August 8, 2013
    Applicant: University of Iowa Research Foundation
    Inventors: Christopher M. Adams, Steven D. Kunkel
  • Publication number: 20130177506
    Abstract: A chewing gum, creamer, powdered supplement or other confection, as a food supplement formulated to combine natural or artificial sweeteners and flavorings with CGA, packaged for retail sale to consumers, for providing an ideal bio-available delivery mode for CGA, a recognized antioxidant and natural metabolic stimulant, as a ready supplement for bioactive immune support and to aid users in management of weight loss, obesity and/or glucose management, or for general health and well-being of users.
    Type: Application
    Filed: October 29, 2012
    Publication date: July 11, 2013
    Inventors: Parker E. Atkins, Donald J. Wold
  • Publication number: 20130137649
    Abstract: This invention demonstrates the therapeutic efficacy of Yang-Gan-Wan (YGW) and its active components, especially in the formulation provided by Sheng-Pu Pharmaceutials, Inc., for treating and preventing liver fibrosis. This invention further demonstrates MeCP2 is an important therapeutic target for YGW and its active ingredients' action against liver fibrosis and cirrhosis.
    Type: Application
    Filed: November 30, 2012
    Publication date: May 30, 2013
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventor: UNIVERSITY OF SOUTHERN CALIFORNIA
  • Publication number: 20130131165
    Abstract: Provided is a process for producing a purified chlorogenic acid-containing preparation, which is useful for the production of a chlorogenic acid-containing beverage with reduced developability of turbidity even in an acidic range. The process for producing a purified chlorogenic acid-containing preparation according to the present invention includes a first step of dispersing or dissolving a chlorogenic acid-containing composition as a starting material in the presence of acid clay or activated clay in a mixed solvent of an organic solvent and water, a second step of removing a deposit from a dispersion or solution obtained by the first step, a third step of adjusting a concentration of chlorogenic acids and pH in a solution, which has been obtained by the second step, to from 1.5 to 10 mass % and from 2 to 4, respectively, and a fourth step of separating the deposit formed in a concentration-adjusted solution obtained by the third step.
    Type: Application
    Filed: July 6, 2011
    Publication date: May 23, 2013
    Applicant: KAO CORPORATION
    Inventors: Yukiteru Sugiyama, Kenji Yamawaki, Yuko Kubo
  • Publication number: 20130129808
    Abstract: A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product.
    Type: Application
    Filed: January 12, 2012
    Publication date: May 23, 2013
    Applicant: Korea Institute of Ceramic Engineering and Technology
    Inventors: Jeong Ho CHANG, Hye Sun LEE, Jin Hyung LEE
  • Publication number: 20130131328
    Abstract: Process for fractioning and refining natural products obtainable from waste vegetal material and particularly from artichoke (Cynara scolymus) production or from other plants of the Cynara genus such as the cultivated or wild cardoon. The process is based on the use of membrane separation technologies envisaging a tangential microfiltration (MF) phase on the raw decoction, followed by tangential ultrafiltration (UF) on the previous MF permeate and reverse osmosis (RO) on the UF permeate, in order to obtain a retentate rich in concentrated active ingredients and a permeate consisting of ultrapure water that is recycled for the preparation of the decoction. The process enables obtaining purified extracts of high biological valence to be used in the pharmaceutical industry, in the nutraceutic sector, in the cosmetics industry and for innovative products in the food industry.
    Type: Application
    Filed: November 5, 2012
    Publication date: May 23, 2013
    Applicants: ISR ECOINDUSTRIA S.R.L.
    Inventors: ISR Ecoindustria S.R.L., Massimo Pizzichini, Annalisa Romani
  • Publication number: 20130053598
    Abstract: The invention relates to a method for producing a cross-coupling product of a benzenoid dizonium salt according to the general formula (I), wherein the groups R1, R2, R3, R4, and R5 represent hydrogen, halogen, an alkyl, alkenyl, aryl, alkoxy, aryloxy, nitro, cyano, hydroxy, acetyl, and/or diazo groups independently of each, and X represents BF4, Cl, F, SO3CH3, CO2CH3, PF6, ClO2CH3, or CIO4, comprising the following steps: (a) providing a benzenoid amide, which with the exception of the diazo function has the same substituents R1, R2, R3, R4, and R5 as the benzenoid diazonium salt of the general formula (I), and hydrolytically cleaving the amide to form an amine or providing a corresponding amine, (b) diazotizing the amine thus obtained or provided with a nitrite, and (c) subsequently reacting the benzenoid diazonium salt with a coupling partner in the presence of a catalyst to form a cross-coupling product, wherein the coupling parter is represented by the general formula (II), R6, R7, and R8 are the same or
    Type: Application
    Filed: April 22, 2010
    Publication date: February 28, 2013
    Applicant: ZYLUM BETEILIGUNGSGESELLSCHAFT MBH & CO. PATENTE II KG
    Inventors: Nicolas Boege, Andreas Kreipl, Bernd Schmidt, Frank Hoelter, René Berger
  • Publication number: 20130006011
    Abstract: The present disclosure relates to a process for pre-treating raw propolis comprising at least one allergenic activity substance, which comprises reacting propolis with a probiotic microorganism containing one or more cinnamoyl-esterase activity enzymes to obtain a semisolid propolis derivative substantially without or impoverished of allergenic substances. The present invention also relates to a method of purifying semisolid propolis derivative to obtain a hydroalcoholic hydrodispersible propolis derivative.
    Type: Application
    Filed: March 15, 2011
    Publication date: January 3, 2013
    Inventors: Giuseppe Maria Ricchiuto, Claudio Sebastiano Gardana, Simone Domenico Guglielmetti
  • Publication number: 20120329832
    Abstract: This invention relates to novel coumarin derivative, formulations comprising same, and to methods of making and using these compounds and formulations, which are useful as repellents against insects and/or pests. The compounds also prevent illness and disease caused by insect/pest-borne vectors, and provide safer, more effective alternatives to existing repellents.
    Type: Application
    Filed: June 21, 2012
    Publication date: December 27, 2012
    Inventors: Jean Delaveau, Emile Vialle, Marc Lemaire, Stephane Pellet-Rostaing, Bruno Andrioletti
  • Publication number: 20120321571
    Abstract: The present invention provides paraben compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration.
    Type: Application
    Filed: January 23, 2012
    Publication date: December 20, 2012
    Applicant: ANTERIOS, INC.
    Inventors: Jonathan EDELSON, Timothy KOTYLA, Klaus THEOBALD
  • Publication number: 20120276651
    Abstract: The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
    Type: Application
    Filed: January 31, 2012
    Publication date: November 1, 2012
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sehoon KIM, Ick Chan Kwon, Jai Kyeong Kim, Chang-Keun Lim, Jeongyun Heo
  • Publication number: 20120238773
    Abstract: A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives.
    Type: Application
    Filed: May 26, 2010
    Publication date: September 20, 2012
    Inventors: T.G. Sambandan, ChoKyun Rha, Anthony J. Sinskey, Ravigadevi Sambanthamurthi, Yew Ai Tan, Kalyana Sundram P. Manickam, Mohd Basri Wahid
  • Patent number: 8257903
    Abstract: The present invention provides a compound that can be used within a resist composition, an intermediate compound for the compound, a positive resist composition, and a method for forming a resist pattern.
    Type: Grant
    Filed: August 3, 2007
    Date of Patent: September 4, 2012
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Daiju Shiono, Hideo Hada
  • Publication number: 20120204283
    Abstract: A new and distinct cultivar of Mentha spicata L. named KI-MsEM0042 and characterized by elevated levels of rosmarinic acid and vigorous growth.
    Type: Application
    Filed: February 7, 2012
    Publication date: August 9, 2012
    Applicant: KEMIN INDUSTRIES, INC.
    Inventors: Brindha Narasimhamoorthy, John A. Greaves, Susan Ruden, Sarah Wildgen, Rachel Barkley
  • Patent number: 8222446
    Abstract: A method of producing a compound represented by the following general formula (3): [wherein R is a bivalent aliphatic group having a carbon number of 1-16 or a bivalent aromatic group], which comprises a step (i) of reacting a compound represented by the following general formula (1): with a carboxylic acid halide represented by the following general formula (2): [wherein R is a bivalent aliphatic group having a carbon number of 1-16 or a bivalent aromatic group and X is a halogen atom] in the presence of a basic compound to form an ester, and a step (ii) of conducting a heat treatment after the step (i) to decompose an oligomer in the ester.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: July 17, 2012
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Akinori Nagatomo, Kouki Oogaki, Takeshi Kobayashi
  • Publication number: 20120165293
    Abstract: The presently disclosed subject matter provides a method of synthesizing prostaglandins and prostaglandin analogs comprising the ring closing metathesis of compounds of Formula (I). Also provided are novel compounds of Formula (I) and Formula (II). In addition to their use as synthetic intermediates in the presently disclosed methods, compounds of Formula (II) can be used as prostaglandin and/or prostaglandin analog prodrugs.
    Type: Application
    Filed: July 13, 2010
    Publication date: June 28, 2012
    Inventors: George Petros Yiannikouros, Panos Kalaritis, Chaminda Priyapushpa Gamage, Stephenie Bosse Abernathy
  • Publication number: 20120149707
    Abstract: The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.
    Type: Application
    Filed: April 21, 2011
    Publication date: June 14, 2012
    Applicant: OSCOTEC INC.
    Inventors: Se-Won Kim, Jung Ho Kim, Se-Nyum Kim, Dae-Pil Kang, Youn Ho Han, Guo Fan Jin, Dong-Sik Jung, Sung-Ho Park, Ji Min Kim, Jhi Zheng
  • Publication number: 20120129818
    Abstract: Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.
    Type: Application
    Filed: April 23, 2010
    Publication date: May 24, 2012
    Inventor: Desikan Rajagopal
  • Publication number: 20120129931
    Abstract: This invention relates to caffeic acid derivatives and improving viability of neuronal cells by contacting neuronal cells by caffeic acid derivatives as shown in the specification.
    Type: Application
    Filed: November 15, 2011
    Publication date: May 24, 2012
    Applicant: ChemiGen
    Inventors: Junyi Liu, Yangsheng Du
  • Publication number: 20120128588
    Abstract: Disclosed are: labeled NSAIDs compounds which can be produced within a short time, can be used suitably for a PET method, and enable the imaging of cyclooxygenase-2; and a process for producing the labeled NSAIDs compounds. Specifically disclosed are isotope-labeled 2-arylpropionic acid compounds, each of which is a compound represented by general formula (1) (wherein Ar represents an aryl group which may have a substituent; R1 represents anyone selected from 11CH3, CH218F and CF218F; and R2 represents a hydrogen atom, or an alkyl group which may have a branch, wherein a compound wherein Ar is a benzene ring, R1 is 11CH3, and R2 is a hydrogen atom is excluded), or a pharmaceutically acceptable salt, hydrate, solvate or prodrug thereof.
    Type: Application
    Filed: July 29, 2010
    Publication date: May 24, 2012
    Inventors: Misato Takashima, Miho Shukuri, Miki Goto, Hisashi Doi, Hirotaka Onoe, Masaaki Suzuki, Yasuyoshi Watanabe
  • Patent number: 8178675
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed as Formula (I).
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: May 15, 2012
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Fedor Evgenievich Romantsev, Shalini Sharma, Reid W. von Borstel, Stephen D. Wolpe