Esterified Phenolic Hydroxy Patents (Class 560/86)
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Publication number: 20150099820Abstract: The present invention relates to a polymerizable liquid crystal compound, a liquid crystal composition including the same, and an optically anisotropic body. The polymerizable liquid crystal compound according to the present invention has not only high birefringence but also excellent coating orientation, and thus it is possible to prepare a optically anisotropic body which is thin but superior in optical properties.Type: ApplicationFiled: June 25, 2013Publication date: April 9, 2015Inventors: Kyung Chang Seo, Sung-Ho Chun, Dai Seung Choi, Mi-Ra Hong, Hyeong Bin Jang
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Publication number: 20150090935Abstract: The invention relates to bimesogenic compounds of formula I wherein R11, R12, MG11, MG12, X11, X12 and Sp1 have the meaning given in claim 1, to the use of bimesogenic compounds of formula I in liquid crystal media and particular to flexoelectric liquid crystal devices comprising a liquid crystal medium according to the present invention. Furthermore the invention relates to bimesogenic compounds of formula I inducing a second nematic phase in nematic mixtures that do not show this additional phase without compounds of formula I.Type: ApplicationFiled: May 7, 2013Publication date: April 2, 2015Applicant: Merck Patent GmbHInventors: Kevin Adlem, Owain Llyr Parri, Rachel Tuffin, Benjamin Snow, Mariam Namutebi
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Patent number: 8816121Abstract: Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analysis of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.Type: GrantFiled: July 8, 2013Date of Patent: August 26, 2014Assignee: Receptos, Inc.Inventors: Marcus F. Boehm, Esther Martinborough, Manisha Moorjani, Liming Huang, Junko Tamiya, Mark T. Griffith, Thomas Fowler, Andrew Novak, Michael Knaggs, Premji Meghani
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Publication number: 20140132899Abstract: The present invention provides a photosensitive monomer, a liquid crystal composition containing the photosensitive monomer and a vertical alignment liquid crystal panel. The range of absorption wavelength of the photosensitive monomer of the present invention overlaps with the range of an ultraviolet lamp by increasing the length of a hard core. Thus, comparing with the conventional reactive monomer (RM), the photosensitive monomer of the present invention has a faster curing speed to solve the image sticking issue due to a high monomer residue.Type: ApplicationFiled: November 19, 2012Publication date: May 15, 2014Applicant: SHENZHEN CHINA STAR OPTOELECTRONICS TECHNOLOGY CO., LTD.Inventor: Chung-Ching Hsieh
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Publication number: 20130338120Abstract: The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.Type: ApplicationFiled: June 14, 2013Publication date: December 19, 2013Inventor: Shengmin Sang
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Publication number: 20130277609Abstract: A compound represented by formula (1), a liquid crystal composition, a liquid crystal display device are described. In formula (1), for example, the ring A1 and the ring A4 are phenylene or cyclohexylene; Z1, Z2, Z3 and Z4 are a single bond or alkylene having 1 to 6 carbons; L1 is a single bond; s and t are 0; and P1, P2, P3 and P4 are a polymerizable group.Type: ApplicationFiled: December 23, 2012Publication date: October 24, 2013Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: YASUYUKI GOTO, MAIKO MATSUKUMA, JUNICHI YAMASHITA
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Patent number: 8501982Abstract: Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.Type: GrantFiled: June 9, 2011Date of Patent: August 6, 2013Assignee: Receptos, Inc.Inventors: Marcus F. Boehm, Esther Martinborough, Manisha Moorjani, Liming Huang, Junko Tamiya, Mark T. Griffith, Thomas Fowler, Andrew Novak, Michael Knaggs, Premji Meghani
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Publication number: 20130122423Abstract: The object is to provide a compound having high dissolvability in a safe solvent and high sensitivity, and also capable of obtaining a good resist pattern shape, a radiation-sensitive composition containing the same, and a resist pattern formation method using the composition. For this purpose, a compound (B) obtained by reaction between a polyphenol based cyclic compound (A) and a compound (C) having a particular structure, a radiation-sensitive composition containing the same, and a resist pattern formation method using the composition are provided.Type: ApplicationFiled: July 25, 2011Publication date: May 16, 2013Inventor: Masatoshi Echigo
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Publication number: 20130053525Abstract: The present disclosure is directed to the production of substituted phenylene aromatic diesters and 5-tert-butyl-3-methyl-1,2-phenylene dibenzoate (or “BMPD”) in particular. The processes disclosed herein produce a liquid BMPD product. The liquid BMPD product unexpectedly creates production efficiencies by reducing the number of production steps, reducing the amount and/or number of reagents required for BMPD production. The liquid BMPD product may also be utilized in procatalyst production yielding similar production efficiencies. The procatalyst composition is subsequently used for olefin polymerization.Type: ApplicationFiled: August 30, 2011Publication date: February 28, 2013Inventors: Michael F. Gullo, Gary A. Roth, Tak W. Leung, Clark C. Williams
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Publication number: 20130035317Abstract: The invention relates to the use of di-aspirin (bis(2-carboxyphenyl)succinate) and its derivatives in the treatment of colon and colorectal cancer. It also relates to novel derivatives of di-aspirin and to a method of synthesis of the di-aspirin and its derivatives.Type: ApplicationFiled: February 15, 2011Publication date: February 7, 2013Inventors: Christopher John Perry, Iain Douglas Nicholl
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Publication number: 20120238774Abstract: The present invention provides a charge transport film which is prepared through subjecting a coating film including at least one charge transporting agent to an atmospheric pressure plasma treatment, wherein electron transfer between the charge transport film and a substance that contacts with the charge transport film is promoted, and deterioration in performance due to diffusion and mixing or crystallization of low molecular weight components, such as a charge transporting agent, incorporated in a cured film is suppressed also in the case of film formation by a wet method, and which exhibits excellent charge transportability and stability over time; a production method with good productivity; and a light-emitting element and photoelectric conversion element equipped with the charge transport film, the atmospheric pressure plasma treatment being preferably a treatment that applies plasma, which is generated using a plasma generating apparatus and conveyed using an inert gas, to the coating film.Type: ApplicationFiled: November 29, 2010Publication date: September 20, 2012Applicant: FUJIFILM CORPORATIONInventors: Naoyuki Hayashi, Yoshio Inagaki, Tasuku Satou, Kana Morohashi, Koji Takaku, Ryo Nishio
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Publication number: 20120175549Abstract: The present invention provides a thermally-conductive organic additive which (i) is an organic polymer, unlike a thermally-conductive inorganic filler such as ceramic, metal and a carbon material, (ii) is capable of imparting thermal conductivity to plastic by being added thereto, (iii) can reduce the weight of a composition even when added to a resin in a large amount, without causing abrasion on molds and deteriorating an electrical insulation property of the composition, and (iv) provides the composition with excellent molding processability. The present thermally-conductive organic additive includes a liquid crystalline thermoplastic resin which has a mainly-chain structure, wherein a main chain of the liquid crystalline thermoplastic resin contains mainly a repeating unit represented by the general formula (1): -M-Sp-??(1) wherein M represents a mesogenic group; and Sp represents a spacer, the liquid crystalline thermoplastic resin itself having thermal conductivity of not less than 0.45 W/(m·K).Type: ApplicationFiled: April 26, 2010Publication date: July 12, 2012Applicant: KANEKA CORPORATIONInventors: Shusuke Yoshihara, Kazuaki Matsumoto
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Publication number: 20120165528Abstract: The present invention relates to chiral binaphthyl compounds having good solubility and high helical twisting power. The chiral binaphthyl compounds as dopants in the liquid crystal compositions can help enhance the display quality of the liquid crystal panels.Type: ApplicationFiled: April 27, 2011Publication date: June 28, 2012Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jian-Wen Lin, Chun-Ming Wu, Shih-Hsien Liu, Kung-Lung Cheng
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Publication number: 20110306542Abstract: Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the GLP-1 receptor. Methods of synthesis, methods of therapeutic and/or prophylactic use, and methods of use in stabilizing GLP-1 receptor in vitro for crystallization of the GLP-1 receptor of such compounds are provided.Type: ApplicationFiled: June 9, 2011Publication date: December 15, 2011Applicant: Receptos, Inc.Inventors: Marcus F. Boehm, Esther Martinborough, Manisha Moorjani, Liming Huang, Junko Tamiya, Mark T. Griffith, Thomas Fowler, Andrew Novak, Michael Knaggs, Premji Meghani
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Publication number: 20110263674Abstract: Active compounds of Formula I are described: wherein: R1 and R2 are each independently C1-C4 alkyl; or R1 and R2 together form a C2-C7 alkylene chain; and Z is a non-steroidal anti-inflammatory drug (NSAID); along with pharmaceutically acceptable salts and prodrug thereof, and methods of using the same.Type: ApplicationFiled: July 6, 2011Publication date: October 27, 2011Inventor: S. Bruce King
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Publication number: 20110236602Abstract: Diamine compounds, which in particular are useful as precursors for the production of liquid crystal alignment layers, are represented by the general formula I: wherein A1 represents an organic group of 1 to 40 carbon atoms; A2 represents a hydrogen atom or an organic group of 1 to 40 carbon atoms.Type: ApplicationFiled: June 13, 2011Publication date: September 29, 2011Applicant: ROLIC AGInventors: Guy MARCK, Olivier MULLER
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Publication number: 20110086900Abstract: The present invention, in one or more embodiments, comprises water-soluble derivatives of 3-n-pentadecylcatechol (poison ivy urushiol saturated congener) and/or 3-n-heptadecylcatechol (poison oak urushiol saturated congener) as compositions for the prevention and/or prophylactic treatment of contact dermatitis caused by poison ivy and poison oak. The present invention is also directed towards processes for making such compounds. Disclosed are compounds which are effective for tolerizing and desensitizing a subject against allergens contained in plants of the Anacardiaceae and Ginkgoaceae families comprising water soluble urushiol esters of general formula (I) Tolerizing and desensitizing mammals, including humans, to allergens contained in plants of the Anacardiaceae and Ginkgoaceae families is attained by administering a composition containing at least one water soluble urushiol ester compound.Type: ApplicationFiled: April 3, 2009Publication date: April 14, 2011Inventors: Mahmoud A. Elsohly, Waseem Gul, Mohammad Khalid Ashfaq, Susan P. Manly
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Publication number: 20100320419Abstract: A polymerizable compound represented by general formula (1): wherein A represents a ring assembly composed of at least two 6-membered rings each optionally having a substituent; X1 and X2 each represent a (meth)acryloyloxy group; and Y1 and Y2 each independently represent a single bond, an optionally branched alkylene group having 1 to 8 carbon atoms, an ether linkage, —COO—, —OCO—, a 6-membered ring optionally having a substituent, a naphthalene ring optionally having a substituent, or a combination thereof; the substituent being a hydrogen atom, a halogen atom, a nitrile group, an optionally branched alkyl group having 1 to 8 carbon atoms, an optionally branched alkoxy group having 1 to 8 carbon atoms, or an optionally branched alkenyl group having 2 to 8 carbon atoms, wherein the alkyl, alkoxy, or alkenyl group may have its —CH2— moiety replaced with a sulfur atom or an oxygen atom and may have its hydrogen atom replaced with a halogen atom or a nitrite group.Type: ApplicationFiled: October 9, 2007Publication date: December 23, 2010Applicant: ADEKA CORPORATIONInventors: Masatomi Irisawa, Mineki Hasegawa
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Publication number: 20100308270Abstract: This invention relates to a liquid crystal composition and articles comprising the composition. The composition comprises at least one compound of each of the Formulas (I), (II) and (III), as defined herein. A process for making the composition is also provided.Type: ApplicationFiled: June 8, 2009Publication date: December 9, 2010Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventor: MARC B. GOLDFINGER
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Publication number: 20100190856Abstract: The present invention relates to new polyhydroxylated compounds and, in particular, to its activity as fatty acid synthase (FASN) inhibitors and to their use for the treatment of pathological states for which an inhibitor of this enzyme is indicated. The invention further relate to pharmaceutical compositions containing them and to a process for the preparation of such compounds.Type: ApplicationFiled: June 25, 2008Publication date: July 29, 2010Applicant: UNIVERSIDAD COMPLUTENSE DE MADRIDInventors: Ramón Colomer Bosch, Teresa Puig Miquel, Joan Brunet Vidal, María Luz López Rrodríguez, Bellinda Benhamú Salama, Silvia Ortega Gutiérrez, Carlos Turrada García
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Patent number: 7674827Abstract: Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds for combating animal pests The present invention relates to Indanyl- and Tetrahydronaphtyl-amino-thiourea compounds of formula I wherein the variables R1 to R4 are as in the description. The invention relates also to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects and to methods for treating, controlling, preventing or protecting animals against infestation or infection.Type: GrantFiled: November 15, 2006Date of Patent: March 9, 2010Assignee: BASF SEInventors: Markus Kordes, Christopher Koradin, Deborah L. Culbertson
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Plasminogen Activator Inhibitor-1 Inhibitors And Methods Of Use Thereof To Modulate Lipid Metabolism
Publication number: 20090011055Abstract: The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.Type: ApplicationFiled: April 16, 2008Publication date: January 8, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Daniel A. Lawrence, Dudley Strickland, Jacqueline Cale, Enming J. Su, Cory Emal, Mark Warnock -
Patent number: 7396487Abstract: A compound of formula (I): where R1 is alkyl or alkenyl, Y1 and Y2 are independently selected from oxygen or sulphur, n is an integer of from 1 to 5, A is an optionally substituted phenyl or an optionally substituted cycloalkyl ring, X is a direct bond, a C1-4alkylene, a C2-4alkenylene, an acetylene, —CO(O)— or a group of sub-formula (i): where X1 and X2 are independently selected from a direct bond, a C1-4alkylene, a C2-4alkenylene, an acetylene, —CO(O)— and R2, R3 and R4 are independently selected from hydrogen, halo or cyano, provided that no more than one of R2, R3 and R4 is hydrogen. These compounds have a high dipole moment and may be used as dopants in liquid crystal mixtures.Type: GrantFiled: January 27, 2003Date of Patent: July 8, 2008Assignee: QinetiQ LimitedInventors: Stephen M Kelly, Warren L Duffy, Neil L Campbell
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Patent number: 7238831Abstract: Novel platform mesogens, intermediates, and polymerizable mesogens made therefrom.Type: GrantFiled: January 23, 2002Date of Patent: July 3, 2007Assignee: Southwest Research InstituteInventors: Stephen T. Wellinghoff, Douglas P. Hanson
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Patent number: 7147800Abstract: A method for making platform molecules comprising: reacting 4-alkoxy benzoyl chloride with R2-hydroquinone under first conditions effective to produce bis 1,4[4-alkoxy-benzoyloxy]-R2-phenylene comprising bis terminal alkoxy groups wherein R2 is a bulky organic group; and, subjecting the bis 1,4[4-alkoxy-benzoyloxy]-R2-phenylene to second conditions effective to selectively cleave the bis terminal alkoxy groups to produce a solution comprising complexes comprising diphenolic platform molecules comprising bis terminal hydroxyl groups, the second conditions also being effective to precipitate the complexes out of the solution.Type: GrantFiled: December 24, 2003Date of Patent: December 12, 2006Assignee: Southwest Research InstituteInventors: Stephen T. Wellinghoff, Douglas P. Hanson
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Publication number: 20040171866Abstract: The invention relates to indanes having negative &Dgr;&egr; of the formula Ia or Ib 1Type: ApplicationFiled: January 20, 2004Publication date: September 2, 2004Inventors: Volker Reiffenrath, Michael Heckmeier, Matthias Bremer
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Publication number: 20020177727Abstract: Novel platform mesogens, intermediates, and polymerizable mesogens made therefrom.Type: ApplicationFiled: January 23, 2002Publication date: November 28, 2002Inventors: Stephen T. Wellinghoff, Douglas P. Hanson
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Patent number: 6444841Abstract: A highly pure hydroquinone dietser derivative can be produced from the reaction product of ketoisophorone with an acylating agent in a high yield by a simple and easy operation. In the presence of an acid catalyst, a cyclohex-2-ene-1,4-dione derivative shown by the following formula (3) was allowed to react with an acylating agent (e.g., acetic anhydride), and the reaction product was purified by crystallization to obtain a hydroquinone diester derivative shown by the following formula (1). The compound (1) contains about 0 to 4% by weight of a catechol diester derivative represented by the following formula (2), being highly pure. As a solvent for crystallization, a mixed solvent of an organic carboxylic acid (e.g., acetic acid) corresponding to the acylating agent and water may be used. In the formulae, R1 and R2 each represents an alkyl group, a cycloalkyl group, an aryl group or a heterocyclic group.Type: GrantFiled: October 30, 1998Date of Patent: September 3, 2002Assignee: Daicel Chemical Industries, Ltd.Inventors: Ikuo Takahashi, Hikaru Shibata
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Patent number: 6440328Abstract: The invention relates to a one-step process for the preparation of acryloyl group-containing liquid-crystalline monomers of the general formula (1) (Z—Y1—A2—Y2—)mM(—O—A1-acrylate)n (1) in which mesogenic alcohols of the general formula (2) (Z—Y1—A2—Y2—)mM(OH)n (2) are reacted with esters of 3-chloropropionic acid of the general formula (3) ClPr—A1—X (3) with elimination of HCl, where acrylate is an acrylate radical, ClPr is a 3-chloropropionate radical, A1 are identical or different alkyl chain spacers having 2-20 carbon atoms, in which the carbon chain may be interrupted by non-adjacent ether, thioether, or imino groups, A2 are radicals A1 or single chemical bonds, M is a mesogenic group, X is a leaving group, Z are alkyl radicals or crosslinkable groups, Y1 and Y2, independently of one another, are a single chemical bond, —O—, —S—, —O—CO—, —COType: GrantFiled: April 18, 2000Date of Patent: August 27, 2002Assignee: Consortium fur Elektrochemische Industrie GmbHInventors: Volker Stanjek, Wolfram Schindler, Thomas Kammel, Norman Häberle
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Publication number: 20020007082Abstract: A highly pure hydroquinone dietser derivative can be produced from the reaction product of ketoisophorone with an acylating agent in a high yield by a simple and easy operation. In the presence of an acid catalyst, a cyclohex-2-ene-1,4-dione derivative shown by the following formula (3) was allowed to react with an acylating agent (e.g., acetic anhydride), and the reaction product was purified by crystallization to obtain a hydroquinone diester derivative shown by the following formula (1). The compound (1) contains about 0 to 4% by weight of a catechol diester derivative represented by the following formula (2), being highly pure. As a solvent for crystallization, a mixed solvent of an organic carboxylic acid (e.g., acetic acid) corresponding to the acylating agent and water may be used.Type: ApplicationFiled: October 30, 1998Publication date: January 17, 2002Inventors: IKUO TAKAHASHI, HIKARU SHIBATA
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Patent number: 6111129Abstract: A process is disclosed for the direct preparation of alkanediol-diaminobenzoates comprising transesterifying an alkyl-p-aminobenzoate with a diol in the presence of a transesterification catalyst.Type: GrantFiled: November 4, 1998Date of Patent: August 29, 2000Assignee: Uniroyal Chemical Company, Inc.Inventors: Franklin H. Barrows, Vincent J. Gajewski
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Patent number: 5955628Abstract: This method provides a novel trimethylcatechol diester, i.e. 3,4,5-trimethylcatechol diester, at a high yield by reacting 2,6,6-trimethylcyclohexe-2-en-1,4-dione with an acylating agent in the presence of an acid catalyst. The acylating agent includes a C.sub.2-4 carboxylic acid anhydride (e.g. acetic anhydride) and a C.sub.2-4 carboxylic acid halide (e.g. acetyl chloride). The catalyst includes a protonic acid and a Lewis acid. Use of a polar solvent (e.g. halogenated hydrocarbon), as the reaction catalyst, results in an enhanced efficiency in the production of the object compound.Type: GrantFiled: December 17, 1997Date of Patent: September 21, 1999Assignee: Daicel Chemical Industries, Ltd.Inventors: Ikuo Takahashi, Masaaki Ito
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Patent number: 5948922Abstract: Compounds containing two cyclic hydrocarbon moieties which are substituted to provide crosslinking functionality and which are linked to each other by secondary or tertiary oxycarbonyl containing moiety are basis for compositions which are cured to provide cured thermosets for encapsulation and underfill for electronic components that are thermally decomposable to allow repair, replacement, recovery or recycling of operative electronic components from assemblies that are inoperative.Type: GrantFiled: February 20, 1997Date of Patent: September 7, 1999Assignee: Cornell Research Foundation, Inc.Inventors: Christopher K. Ober, Hilmar Koerner
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Patent number: 5750711Abstract: The dicarboxylic acid derivatives according to the invention have the following structure ##STR1## wherein X denotes O, S, (CF.sub.2).sub.m, C(CF.sub.3).sub.2 or CF.sub.2 --CF(CF.sub.3) (m=1 to 10), and R stems from the following compounds: fluoro- or trifluoromethyl- and nitro- or cyanophenols, thiophenols or -aminobenzenes, 4-hydroxy-, 4-mercapto- or 4-aminocoumarins, N-hydroxysuccinimides or N-hydroxymaleimides, 2-hydroxy- or 2-mercaptobenzoxazoles or -benzothiazoles and 1-hydroxy- or 1-mercaptobenzotriazoles.Type: GrantFiled: August 28, 1996Date of Patent: May 12, 1998Assignee: Siemens AktiengesellschaftInventors: Racai Sezi, Hellmut Ahne, Eberhard Kuehn
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Patent number: 5618907Abstract: The yield of fully substituted, multidimensional aromatic hubs in the condensation of hydroxyl and acid halide functionalities is improved by adding a thallium catalyst, such as thallium ethoxide (Tl--OC.sub.2 H.sub.5), in the solvent.Type: GrantFiled: June 5, 1995Date of Patent: April 8, 1997Assignee: The Boeing CompanyInventors: Hyman R. Lubowitz, Clyde H. Sheppard, Ronald R. Stephenson
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Patent number: 5599974Abstract: Chemical compounds which interact inside the central water cavity of hemoglobin and bridge between the two .alpha. subunits can be used to allosterically modify hemoglobin towards tense and relaxed states. The functional groups employed are aldehydes and carboxylic acids, wherein the aldehydes form covalent bonds (schiff base) with amino acid residues of hemoglobin and the carboxylic acids form ionic bonds with amino acid residues of hemoglobin. Particularly useful compounds within the practice of this invention bond to the n-terminal valine of one .alpha. subunit of hemoglobin, and the lysine 99 and/or arginine 141 of the other .alpha. subunit.Type: GrantFiled: September 19, 1994Date of Patent: February 4, 1997Assignee: Center for Innovative TechnologyInventors: Donald J. Abraham, Telih Boyiri, Martin Safo, Richmond Danso-Danquah
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Patent number: 5597943Abstract: The present invention relates to the new thielocin derivatives, which exhibit phospholipase A.sub.2 inhibitory activity of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy, or halogen;E.sub.1 and E.sub.2 are independently hydrogen, or an ester residue;m and n are independently an integer of 0 to 4;--Y-- is a bivalent group which is selected from the group consisiting of the following radicals: ##STR2## or the salts thereof.Type: GrantFiled: December 13, 1995Date of Patent: January 28, 1997Assignee: Shionogi & Co., Ltd.Inventors: Mitsuaki Ohtani, Shigeru Matsutani, Tadashi Yoshida, Kazushige Tanaka, Yasuhiko Fujii, Kazuhiro Shirahase
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Patent number: 5510497Abstract: Aliphatic cyclobutene compositions according to the formula ##STR1## can be homopolymerized or copolymerized with a variety of comonomers, including bismaleimides, to produce tough, low dielectric constant resins.Type: GrantFiled: October 30, 1992Date of Patent: April 23, 1996Assignee: Shell Oil CompanyInventor: Larry S. Corley
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Patent number: 5476888Abstract: The diposphines have the formula (I) ##STR1## wherein: R.sup.2, R.sup.3 and R.sup.4 independently from each other represent a hydrocarbyl group which is substituted with one or more radicals selected from the group consisting of halogen, alkyl and alkoxy, andA is --C(O)--, --S(O).sub.2 --, --S(O)-- or certain divalent organic groups.The diphosphines are useful for stabilizing thermoplastic polymers, such as polycarbonates, against thermal discoloration.Type: GrantFiled: September 2, 1994Date of Patent: December 19, 1995Assignee: The Dow Chemical CompanyInventors: Jurgen Eiffler, Gunter A. Juptner, David P. Flores
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Patent number: 5442096Abstract: A homopolymer or a copolymer comprises a polymerizable compound represented by formula (I):A--X--COCOOR.sub.1 (I)wherein R.sub.1 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or an aryl group; X represents an oxygen atom, a sulfur atom, --COO-- or --NR.sub.5 -- wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; A represents a C.sub.3 -C.sub.18 alkenyl, alkynyl, alkenylaryl or alkenylaralkyl group, or a group represented by: ##STR1## wherein R.sub.2 and R.sub.3, which may be the same or different, independently represent a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; Y represents an oxygen atom or --NR.sub.4 -- wherein R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.5 alkyl group; n is an integer of 1 to 5; m is an integer of 1 to 10; and 1 is 0 or an integer of 1 to 20;with the proviso that if Y is present, X is not --NR.sub.5 --. Additionally, disclosed are processes of preparing the homopolymer or copolymer as well as the polymerizable compound.Type: GrantFiled: July 2, 1993Date of Patent: August 15, 1995Assignee: Nippon Paint Co., Ltd.Inventors: Satoshi Urano, Kei Aoki, Nobuaki Tomita, Hirohiko Mori
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Patent number: 5399673Abstract: Compounds containing at least one alkenyl group, at least one maleimide group and at least one rodlike mesogenic moiety are prepared by reacting one or more aminophenols containing one or more rodlike mesogenic moieties with a stoichiometric quantity of a maleic anhydride per amine group of said aminophenol and then alkenylating the resulting phenolic functional maleimide.Type: GrantFiled: February 9, 1993Date of Patent: March 21, 1995Assignee: The Dow Chemical CompanyInventor: Robert E. Hefner, Jr.
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Patent number: 5334766Abstract: A process for the resolution of racemic diphosphine oxides into the optically active antipodes by reacting the racemate with a resolving agent comprising using a carbamate or thiocarbamate of an optically active .alpha.-hydroxycarboxylic acid or .alpha.-aminocarboxylic acid as the resolving agent.Type: GrantFiled: April 9, 1992Date of Patent: August 2, 1994Assignee: Hoffmann-La Roche Inc.Inventors: Marco Cereghetti, Alain Rageot
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Patent number: 5332858Abstract: The invention relates to a method for preparing an ester composition in which at least one activated phenolic ether group of a molecule is reacted with at least one haloformyl group of another molecule.Type: GrantFiled: July 17, 1992Date of Patent: July 26, 1994Assignee: Shell Oil CompanyInventors: Feike De Jong, Jan H. H. Meurs
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Patent number: 5330678Abstract: Disclosed are novel liquid crystal compounds containing a naphthalene ring, having an excellent light leaking ratio at tristable states, and represented by the following formula: ##STR1## wherein R.sub.1 is a C.sub.6 -C.sub.16 linear alkyl group or C.sub.6 -C.sub.16 linear alkoxy group, R.sub.2 is a C.sub.4 -C.sub.12 linear alkyl group, R.sub.3 is a C.sub.1 -C.sub.3 alkyl group or C.sub.1 -C.sub.3 haloalkyl group, and C having an asterisk indicates an asymmetric atom.The liquid crystal compounds are expected to find their applications in electrooptical devices and liquid crystal displays utilizing a S*.sub.(3) liquid crystal phase which shows tristable states.Type: GrantFiled: May 25, 1993Date of Patent: July 19, 1994Assignee: Showa Shell Sekiyu Kabushiki KaishaInventors: Nobuhiro Okabe, Hiroyuki Mogamiya, Noriko Yamakawa
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Patent number: 5322954Abstract: Disclosed is a method of making a 4-substituted phthalic anhydride. A halomaleic (including halofumaric anhydride (or the acid or ester thereof) is made by the reaction of-maleic anhydride with chlorine or bromine. The halomaleic anhydride is reacted with a conjugated diene to form a first cycloadduct having the formula ##STR1## The first cycloadduct is heated to eliminate HX and produce a second cycloadduct having the formula ##STR2## The second cyclo adduct is dehydrogenated to produce a 4substituted phthalic anhydride which has the formula ##STR3## where R.sub.1, R.sub.2, and R.sub.4 are preferably H and R.sub.3 is preferably Cl or F.Type: GrantFiled: May 28, 1993Date of Patent: June 21, 1994Assignee: Occidental Chemical CorporationInventors: Karl W. Seper, Jeffrey S. Stults, Gary H. Olsen
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Patent number: 5294732Abstract: The present invention is directed to polysubstituted fullerene moieties having a plurality of substituents thereon wherein the substituents are selected from the group consisting of hydroxy in combination with hydroxy, amino, oxide, nitro, organocarboxy, amide and mixtures thereof.Type: GrantFiled: December 23, 1992Date of Patent: March 15, 1994Assignee: Exxon Research & Engineering Co.Inventors: Long Y. Chiang, Ravindra B. Upasanti, John W. Swirczewski
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Patent number: 5248727Abstract: Thermoplastic molding compositions of a vinyl chloride polymer and one or more emulsion polymers made with special emulsifiers have improved properties for technical application, such as reduced fogging. They are used for the production of molded articles, sheet products and films.Type: GrantFiled: May 18, 1992Date of Patent: September 28, 1993Assignee: Bayer AktiengesellschaftInventors: Christian Lindner, Adolf Schmidt, Herbert Eichenauer, Karl-Erwin Piejko, Karl-Heinz Ott
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Patent number: 5198572Abstract: A composition and method of making copolymers of salicylic acid and dicarboxylic acid by reacting at least one salicylic acid with at least one dicarboxylic acid and at least one acetic anhydride for every salicylic and dicarboxylic acid present. The composition is useful for functionalizing polyphenylene ethers that are capable of forming copolymers useful for compatibilizing blends of polyphenylene ethers and polyamides.Type: GrantFiled: February 4, 1991Date of Patent: March 30, 1993Assignee: General Electric CompanyInventors: Dwain M. White, Laura A. Socha
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Patent number: 5177248Abstract: The present invention is directed toward the preparation of novel polysubstituted fullerenes. The method of forming polysubstituted fullerenes comprises contacting a fullerene with an electrophilic reagent selected from the group consisting of nitronium ion and organic peracid, provided that when the electrophilic reagent is nitronium ion, the fullerene is subsequently contacted with a nucleophilic reagent.Type: GrantFiled: October 28, 1991Date of Patent: January 5, 1993Assignee: Exxon Research and Engineering CompanyInventors: Long Y. Chiang, Ravindra B. Upasani, John W. Swirczewski
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Patent number: 5142088Abstract: Ester polyphenols such as the tris(bisphenol A) ester of trimellitic acid are prepared by the reaction of the corresponding aromatic poly(acyl halide) with a dihydroxyaromatic compound such as bisphenol A. They may be employed in the preparation of branched polycarbonates via chloroformate oligomer compositions.Type: GrantFiled: January 28, 1991Date of Patent: August 25, 1992Assignee: General Electric CompanyInventors: Peter D. Phelps, Eugene P. Boden, Paul W. Buckley