Addition Salts Having Organic Nitrogen Containing Cation Patents (Class 562/114)
  • Patent number: 9212263
    Abstract: A reactive ionic liquid to be used as an ionic component that is contained in an ion-containing layer in a transducer arranged in contact with a high-resistance layer as a dielectric layer of the transducer, and is restrained from migrating from the ion-containing layer to the high-resistance layer on application of a voltage is provided. The reactive ionic liquid comprises an ion pair that consists of an anion and a cation. In the reactive ionic liquid, (a) the anion comprises (a1) a reactive group that consists of an alkoxysilyl group and (a2) an anionic group consisting of a carboxylate (—COO?) group or a sulfonate (—SO3?) group. (b) The cation (b1) consists of an imidazolium, ammonium, pyrrolidinium, morpholinium, or phosphonium cation, and (b2) does not comprise an N—H group or a P—H group.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: December 15, 2015
    Assignees: SUMITOMO RIKO COMPANY LIMITED, KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION
    Inventors: Shigeaki Takamatsu, Ryosuke Matsuno, Shingi Kumagai, Yota Kokubo, Kazunobu Hashimoto, Hitoshi Yoshikawa, Atsushi Takahara, Hideyuki Otsuka
  • Publication number: 20150080601
    Abstract: The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C12-C20 normal alpha olefins: and neutralizing the isomerized alpha olefin sulfonic acid with a source of an alkali metal or ammonium or substituted ammonium ion.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 19, 2015
    Inventors: Curtis B. Campbell, Andrew J. Howes
  • Publication number: 20140243247
    Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.
    Type: Application
    Filed: May 14, 2014
    Publication date: August 28, 2014
    Applicant: The Lubrizol Corporation
    Inventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Giesleman, Christopher L. Friend, Patrick E. Mosier, Michele M. Rogers, Mark T. Tierney
  • Publication number: 20140238900
    Abstract: The present invention is related to formulations consisting by block copolymers ?,?-di-aryl or alkyl sulfonates of poly(ethylene oxide)w-poly(propylene oxide)-poly(ethylene oxide)w of bis-ammonium and block copolymers ?,?-di-amine of poly(ethylene oxide)w-poly(propylene oxide)-poly(ethylene oxide)w, that are effective in the dewatering and desalting crude whose specific gravities are within the range of 14 to 23° API.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Inventors: Eugenio Alejandro FLORES OROPEZA, Cesar Andres FLORES SANDOVAL, Reyna REYES MARTINEZ, Jose Gonzalo HERNANDEZ CORTEZ, Alfonso LOPEZ ORTEGA, Laura Veronica CASTRO SOTELO, Fernando ALVAREZ RAMIREZ, Arquimedes ESTRADA MARTINEZ, Flavio Salvador VAZQUEZ MORENO
  • Patent number: 8614346
    Abstract: The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.
    Type: Grant
    Filed: June 18, 2010
    Date of Patent: December 24, 2013
    Assignee: Cambrex Charles City, Inc.
    Inventors: Paul Alan Jass, Todd Jeffrey Johnson, Jason Scott Douglas, Matthew Wendell Schiesher
  • Publication number: 20130289112
    Abstract: Salts of kukoamine B, their preparation method and their pharmaceutical use in preparation of drugs for preventing and treating sepsis. Experiments indicate that salts of kukoamine B have a good effect on antagonizing the key factors inducing sepsis, and can be used in the preparation of drugs for preventing and treating sepsis. Under the current circumstances of the lack of effective measures for the treatment of sepsis in clinical practice, the medicinal formulations, which comprise the salts of kukoamine B, pharmaceutically acceptable carrier and/or diluent, provide a new approach for the prevention and treatment of sepsis.
    Type: Application
    Filed: March 21, 2011
    Publication date: October 31, 2013
    Applicant: TIANJIN CHASESUN PHARMACEUTICAL CO., LTD
    Inventors: Jiang Zheng, Xinchuan Zheng, Xin Liu, Hong Zhou, Ning Wang, Hongwei Cao, Yan Li, Yongling Lu, Kecen Zhao, Jingcheng Yang, Yang Yang, Yuanfeng Zhu, Guo Wei, Min Huang
  • Patent number: 8546609
    Abstract: Problem: Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point. Means for Solving the Problem: The present invention is the invention of the ionic liquid represented by the general formula [1]: {wherein, R1 to R3 and n pieces of R4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R5 to R7 each independently represent alkyl group, aralkyl group, or aryl group, R8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R1 to R7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R3 and R4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R5 to R7 or R5 to R6 may form hetero ring with nitrogen atom binding thereto}.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: October 1, 2013
    Assignee: Wako Pure Chemical Industries, Ltd.
    Inventors: Tsutomu Watahiki, Kuniaki Okamoto, Motoshige Sumino
  • Publication number: 20130137772
    Abstract: A salt of a polyamine having the formula: with a pharmaceutically acceptable organic or inorganic acid, wherein at least one of the bridging groups ALK1, ALK2 and ALK3 contains at least one —CH(OH)-group which is not alpha- to any of the nitrogen atoms.
    Type: Application
    Filed: November 29, 2011
    Publication date: May 30, 2013
    Inventor: Raymond J. Bergeron
  • Publication number: 20130039983
    Abstract: The invention relates to a new process for the production and/or purification of the salt of the compound (S)-2-[4-(2-fluorobenzyloxy)benzylamino]propanamide, i.e. ralfinamide, or the respective R-enantiomer, with methanesulfonic acid in high yields and very high enantiomeric and chemical purity in the form of the crystalline anhydrous polymorph identified as form A, wherein said salt is substantially free from impurities having genotoxic effect, such as (C1-C5)alkanylmethanesulfonates, and residual solvents known as potential precursors thereof, such as (C1-C5)alkanols or esters thereof with lower alkanoic acids.
    Type: Application
    Filed: April 6, 2011
    Publication date: February 14, 2013
    Applicant: NEWRON PHARMACEUTICALS S.P.A.
    Inventors: Claudio Giordano, Erwin Waldvogel
  • Publication number: 20120316350
    Abstract: A process for the preparation of N-monosubstituted ?-aminoalcohol sulfonates of formula (1a), (1b): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues; including a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, said organic solvent which can include water to provide N-monosubstituted ?-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and b) asymmetrically hydrogenating.
    Type: Application
    Filed: July 27, 2012
    Publication date: December 13, 2012
    Applicant: Lonza AG
    Inventors: Walter Brieden, Martin Clausen, John McGarrity, Hanspeter Mettler, Dominique Michel
  • Patent number: 8283491
    Abstract: The present invention is directed to an isomerized alpha olefin sulfonate and a method of making the same wherein the isomerized alpha olefin sulfonate is derived from sulfonating an isomerized alpha olefin with sulfur trioxide in the presence of air thereby producing an isomerized alpha olefin sulfonic acid, wherein the isomerized alpha olefin is derived from the isomerization of C12-C40 normal alpha olefins; and neutralizing the isomerized alpha olefin sulfonic acid with a source of a mono-valent cation.
    Type: Grant
    Filed: October 23, 2008
    Date of Patent: October 9, 2012
    Assignee: Chevron Oronite Company LLC
    Inventors: Curtis Bay Campbell, Theresa Ann Denslow
  • Publication number: 20120226030
    Abstract: Rinsable dyes with improved fugitivity are formulated by attaching dyestuff compounds with amine-capped sulfonic solubilizing groups to commercially available ethoxylated aniline, so that the surfactant effect of the ethoxylated aniline counteracts the substantivity of the dyestuff compound, while the neutralization of the sulfonic solubilizing groups reduces substantivity.
    Type: Application
    Filed: May 16, 2012
    Publication date: September 6, 2012
    Inventors: Mark Berenfeld, Sai Harfouch, Peter Caputo
  • Patent number: 8258338
    Abstract: A process for the preparation of N-monosubstituted ?-aminoalcohol sulfonates of formula (Ia), (Ib): wherein R1 is C6-20-aryl or C4-12-heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups, R2 is C1-4-alkyl or C6-20-aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C1-4-alkyl or C1-4-alkoxy groups and wherein R3 is selected from the group consisting of C1-18-alkyl, C6-20-cycloalkyl, C6-20-aryl and C7-20-aralkyl residues. The process has the steps of (a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, the organic solvent optionally containing water, to afford N-monosubstituted ?-aminoketone sulfonates of formula (II): wherein R1, R2 and R3 are as defined above, and (b) asymmetrically hydrogenating.
    Type: Grant
    Filed: February 14, 2006
    Date of Patent: September 4, 2012
    Assignee: Lonza AG
    Inventors: Walter Brieden, Martin Clausen, John McGarrity, Hanspeter Mettler, Colette Mettler, legal representative, Dominique Michel
  • Publication number: 20120190880
    Abstract: The invention provides methods and compositions for preparing amphetamine conjugates, such as lisdexamfetamine, homoarginine-D-amphetamine, and salts thereof. In one embodiment, the invention provides methods of preparing an amphetamine conjugate from a chloramphetamine intermediate.
    Type: Application
    Filed: June 18, 2010
    Publication date: July 26, 2012
    Inventors: Paul Alan Jass, Todd Jeffrey Johnson, Jason Scott Douglas, Matthew Wendell Schiesher
  • Publication number: 20120157680
    Abstract: PROBLEM: Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point. MEANS FOR SOLVING THE PROBLEM: The present invention is the invention of the ionic liquid represented by the general formula [1]: {wherein, R1 to R3 and n pieces of R4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R5 to R7 each independently represent alkyl group, aralkyl group, or aryl group, R8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R1 to R7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R3 and R4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R5 to R7 or R5 to R6 may form hetero ring with nitrogen atom binding thereto}.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 21, 2012
    Applicant: Wako Pure Chemical Industries, Ltd.
    Inventors: Tsutomu Watahiki, Kuniaki Okamoto, Motoshige Sumino
  • Patent number: 8173353
    Abstract: The present invention provides a sulfonium compound represented by the formula (I): wherein Q1 and Q2 each independently represent a fluorine atom or a C1-C6 perfluoroalkyl group, R1 represents a C5-C42 organic group having a ?-ketoester structure and A+ represents an organic counter ion, and a chemically amplified photoresist composition comprising the above-mentioned sulfonium compound and a resin comprising a structural unit having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solution by the action of an acid.
    Type: Grant
    Filed: March 23, 2010
    Date of Patent: May 8, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Tatsuro Masuyama, Junji Shigematsu, Hanwoo Park
  • Publication number: 20120101168
    Abstract: The subject invention provides deuterated rasagiline, its salts and uses.
    Type: Application
    Filed: October 25, 2011
    Publication date: April 26, 2012
    Inventors: Eliezer Bahar, Anton Frenkel, Victor Piryatinsky
  • Publication number: 20120100184
    Abstract: Process for manufacturing 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate comprising step (i): (i) reacting 1-amino-1,3,3,5,5-pentamethylcyclohexane with methane sulfonic acid in a solvent or a mixture of two or more solvents selected from anisole, cumene, pentane, hexane, heptane, isooctane, methyl acetate, propyl acetate, isopropyl acetate, n-butyl acetate, isobutyl acetate, methyl ethyl ketone, methyl isopropylketone, methyl isobutyl ketone, dimethyl sulphoxide, tetrahydrofuran, methyltetrahydrofuran, 1,1-diethoxypropane, 1,1-dimethoxymethane, and 2,2-dimethoxypropane.
    Type: Application
    Filed: April 16, 2010
    Publication date: April 26, 2012
    Applicant: MERZ PHARMA GmbH & CO.KGaA
    Inventors: Markus Henrich, Simona Negura, Gergely Tasi, Pal Kocsan, Federico Sbrogio, Michael Pyerin, Herbert Koller
  • Patent number: 8134024
    Abstract: Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid, which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of 2-acrylamido-2-methyl-1-propanesulfonic acid-ammonium salt polymer is accomplished by adding 2,2?-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: March 13, 2012
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Holly L Ricks-Laskoski, Arthur W Snow
  • Publication number: 20110152537
    Abstract: The present invention relates to chemical compounds comprising a [Y(CHRa)n—CH(Ra)SO3]? anion, their preparation and application. The chemical compounds are preferably ionic liquids.
    Type: Application
    Filed: May 12, 2009
    Publication date: June 23, 2011
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Peter Wasserscheid, Natalia Paape, Andreas Boesmann, Peter Schulz
  • Publication number: 20110112200
    Abstract: The present invention provides crystalline and amorphous salts of O-desmethylvenlafaxine and processes for preparing said salts of O-desmethylvenlafaxine. The present invention further provides pharmaceutical compositions comprising said salts of O-desmethylvenlafaxine.
    Type: Application
    Filed: June 16, 2009
    Publication date: May 12, 2011
    Inventors: Valerie Niddam-Hildesheim, Tamar Nidam, Eli Lancry
  • Publication number: 20110105788
    Abstract: The invention relates to a polymorphic form of rasagiline mesylate, and to processes for preparing the same.
    Type: Application
    Filed: March 27, 2009
    Publication date: May 5, 2011
    Applicant: MEDICHEM, S.A.
    Inventors: Stephen Benedict David Winter, Maria Carmen Burgarolas Montero
  • Patent number: 7858822
    Abstract: Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS-ammonium salt polymer is accomplished by adding 2,2?-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: December 28, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Holly L. Ricks-Laskoski, Arthur W Snow
  • Patent number: 7807852
    Abstract: Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS-ammonium salt polymer is accomplished by adding 2,2?-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: October 5, 2010
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Holly L. Ricks-Laskoski, Arthur W. Snow
  • Patent number: 7713679
    Abstract: There is provided a compound represented by a general formula (B1-1) shown below, an acid generator composed of the above compound, a resist composition containing an acid generator composed of the above compound, and a method of forming a resist pattern: (wherein RX represents a hydrocarbon group which may contain a substituent group; Q1 represents an alkylene group of 1 to 12 carbon atoms which may contain a substituent group, or a single bond; n represents an integer of 0 or 1; Y1 represents an alkylene group of 1 to 4 carbon atoms, or a fluorinated alkylene group of 1 to 4 carbon atoms; and A+ represents an organic cation which contains a nitrogen atom).
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: May 11, 2010
    Inventors: Keita Ishiduka, Yoshiyuki Utsumi, Akiya Kawaue, Takehiro Seshimo, Hideo Hada
  • Publication number: 20090176963
    Abstract: Provided is a new organic-acid-based catalyst enabling production of a polyhydroxycarboxylic acid by direct dehydration polycondensation of a hydroxycarboxylic acid such as L-lactic acid, specifically, an organic-acid-based catalyst comprising an amine salt of a sulfonic acid or a phosphine salt of a sulfonic acid for production of polyhydroxycarboxylic acids such as poly-L-lactic acid.
    Type: Application
    Filed: June 12, 2007
    Publication date: July 9, 2009
    Inventors: Atsushi Abiko, Hisako Iwahashi
  • Patent number: 7534906
    Abstract: The invention concerns a method for synthesis of hydrogenofluoromethylenesulphonyl radical derivatives, comprising: a) a step which consists in condensing a thiolate (that is a monoalkyl sulphide salt) with a compound having a sp; 3hybridized carbon bearing a hydrogen, a fluorine, a heavy halogen selected among chlorine, bromine and iodine and an electron-attracting group selected among fluorine and those whereof the; is not less than 0.2, advantageously than 0.4; b) a step which consists in oxidizing the compound obtained in step a). The invention is applicable to the synthesis of various compounds having a suphinyl or sulphonyl group.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: May 19, 2009
    Assignee: Rhodia Chimie
    Inventor: Laurent Saint-Jalmes
  • Patent number: 7189798
    Abstract: This invention relates to new cyclodextrin derivatives, processes for producing these cyclodextrin derivatives, and inclusion complexes comprised of the new cyclodextrin derivatives and guest molecules, as well as methods of making such materials and related materials and methods of using the same.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: March 13, 2007
    Assignee: Eastman Chemical Company
    Inventors: Charles M. Buchanan, Steven N. Falling, Juanelle L. Lambert, Shannon E. Large, Jozsef Szejtli, Lajos Szente, Laszlo Jicsinszky
  • Patent number: 7060851
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: June 13, 2006
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A Przybyla, Shu-Hong Zhang
  • Patent number: 6900245
    Abstract: The present invention relates to a pharmaceutical composition for treating or preventing obesity, comprising novel crystalline sibutramine methanesulfonate hemihydrate of formula (I).
    Type: Grant
    Filed: October 3, 2003
    Date of Patent: May 31, 2005
    Assignee: Hanmi Pharm. Co., Ltd.
    Inventors: Jae-Heon Lee, Gha-Seung Park, Jae-Cheol Lee, Han-Kyong Kim, Young-Kil Chang, Gwan-Sun Lee
  • Patent number: 6858414
    Abstract: The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: February 22, 2005
    Assignee: Biogal Gyógyszergyár Rt.
    Inventors: Vilmos Keri, Zoltan Czovek, Attila Mezo
  • Patent number: 6849760
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: February 1, 2005
    Assignee: G. D. Searle & Co.
    Inventors: John S Ng, Claire S Przybyla, Shu-Hong Zhang
  • Patent number: 6765112
    Abstract: A process that can be used for manufacturing a tetraalkylonium perfluoroalkylsulfonate is provided. The process comprises contacting a tetraalkylonium halide with a metal perfluoroalkyl sulfonate to produce a mixture; allowing the second mixture to produce an aqueous upper layer and a separate lower liquid layer; separating the lower liquid layer from the upper aqueous layers to produce a product layer; optionally washing the product layer with 1 to 10 volumes of water, based on the volume of the product layer at a temperature of about 50° C. to about 100° C. to produce a washed product layer; and drying the product layer or washed product.
    Type: Grant
    Filed: March 25, 2003
    Date of Patent: July 20, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventor: James A. Schultz
  • Publication number: 20030198607
    Abstract: Compounds of Formula I 1
    Type: Application
    Filed: April 10, 2002
    Publication date: October 23, 2003
    Applicant: EM Industries
    Inventor: Ratan K. Chaudhuri
  • Patent number: 6521785
    Abstract: The present invention relates to surfactants useful in life science and industrial formulations. More particularly, the invention relates to surfactants of alkoxylated amine neutralized by aromatic sulfonic acid and pesticide formulations containing the same.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: February 18, 2003
    Assignee: Syngenta Participations AG
    Inventors: Tammy Tyler Shannon, Carolyn Estep Moore, Victor Shui-Chiu Chow
  • Patent number: 6506804
    Abstract: Disclosed are ethylenically unsaturated amine salts of sulfonic, phosphoric and carboxylic acids. The salts are surface active agents which are useful in a variety of applications as primary and/or secondary surfactants. The salts are especially useful as surfactants in emulsion polymerization reactions.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: January 14, 2003
    Assignee: Stepan Company
    Inventor: Alfred K. Schultz
  • Patent number: 6388126
    Abstract: The invention features the use of flourosulphonates to release the organic bases from their fluorohydrate. This use is characterised in that a hydrogenofluorosulphonate of an organic base is formed and in that the hydrofuoric acid which is associated with the said base or with one of its precursors is separated therefrom. The invention is useful in organic synthesis applications.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: May 14, 2002
    Assignee: Rhodia Chimie
    Inventors: Laurent Saint-Jalmes, Marcel Morel
  • Patent number: 5866040
    Abstract: A novel complex containing an ampholytic and/or semi-polar surfactant as well as a higher fatty acid, and if necessary, a clay mineral, and an emulsified composition containing this complex.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: February 2, 1999
    Assignee: Shiseido Company, Ltd.
    Inventors: Yasunari Nakama, Michihiro Yamaguchi, Kiyoshi Miyazawa, Takayuki Ohmura
  • Patent number: 5814110
    Abstract: Distillate fuel is treated with additives whose structure match the crystal planes of the wax which crystallizes from the fuel to produce crystals below 4000 nanometres in size, suitable additive include novel sulpho-carboxylic materials particularly their esters and amine derivatives such as the amine salts and/or amides of ortho-sulpho benzoic acid.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: September 29, 1998
    Assignee: Exxon Chemical Patents Inc.
    Inventors: Kenneth William Bartz, Jacqueline Dawn Bland, David Paul Gillingham, Richard Dix Kerwood, Edwin William Lehmann, Kenneth Lewtas, John Edward Maddox, Albert Rossi, Robert Dryden Tack
  • Patent number: 5411933
    Abstract: Antimicrobial compounds of the formula ##STR1## wherein R, R.sup.1 and R.sup.2 are selected according to the following:A. R is (C.sub.11 -C.sub.16) alkyl (straight or branched), and R.sup.1 and R.sup.2 are joined to form a morpholine, pyrrolidine, or piperidine ring with the N;B. R is (C.sub.11 -C.sub.16) and R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.3) alkyl which in the case of C.sub.3 can be branched; andC. R.sup.1 and R.sup.2 are the same and are (C.sub.6 -C.sub.12) alkyl, straight or branched, and R is (C.sub.1 -C.sub.16) alkyl, straight or branched; andX.sup.- =an anion preferably selected from chlorine, bromine, iodine, phosphate, acetate, benzoate, citrate, tartrate, alkyl- or aryl-sulfonate, and alkylsulfate.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: May 2, 1995
    Assignee: Rohm & Haas Company
    Inventor: Adam C. Hsu
  • Patent number: 5374771
    Abstract: A process for the preparation of high-purity deferoxamine salts from filtered fermentation liquors containing deferoxamine B as active ingredient by the adsorption of the active ingredient onto an ion exchange resin and the subsequent dissolution and purification thereof, which comprises carrying out the separation of the deferoxamine salt subsequent to the concentration of the eluate by salting out from an aqueous solution or from a mixture of water and an organic solvent and purifying it by repeated salting out and/or by methods known per se, and optionallya) preparing the methanesulfonate salt by known methods, orb) passing the aqueous solution of the deferoxamine salt trough an ion exchange resin containing methanesulfonate anions as counter ions and recovering the methanesulfonate salt from the effluent, preferably by lyophilization.
    Type: Grant
    Filed: May 27, 1993
    Date of Patent: December 20, 1994
    Assignee: Biogal Gyogyszergyar Rt.
    Inventors: Zoltan Konyari, Vilmos Keri, Antal Kovacs, Sandor Horkay, Laszlo Eszenyi, Janos Erdelyi, Ilona Himesi, Gyorgy Toth, Janos Balint, SzilaJudit, Ferenc Vinczi, Csaba Szabo, Nelli Sas
  • Patent number: 5344949
    Abstract: Surface active anion-cation complexes are synthesized where an organic or organosilicon compound with at least one epoxide group is reacted with a quaternary ammonium hydrogen sulfite of the general formulaHN.sup.+ (R.sup.1).sub.3 SO.sub.3 H.sup.- IwhereinR.sup.1 within the molecule is the same or different and can be(1) an alkyl or hydroxyalkyl group with 1 to 18 carbon atoms,(2) a phenyl group, or(3) a group of the formula C.sub.n H.sub.2n+1 CONH--(CH.sub.2).sub.m --, in which n can be a number from 7 to 17 and m is 2 or 3,in the presence of a polar solvent in such amounts so that the molar ratio of the epoxide group to HN.sup.+ (R.sup.1).sub.3 SO.sub.3 H.sup.- is 2:1.
    Type: Grant
    Filed: July 14, 1993
    Date of Patent: September 6, 1994
    Assignee: Th. Goldschmidt AG
    Inventors: Gotz Koerner, Klaus-Dieter Klein, Dietmar Schaefer
  • Patent number: 5246965
    Abstract: The invention relates to the compounds of the formula ##STR1## wherein the C(.dbd.NH)--NHR group may be in tautomeric or isomeric form, and pharmaceutically acceptable salts thereof, in which:R is hydrogen or an acyl radical which is derived from an organic carbonic acid, an organic carboxylic acid, a sulfonic acid, or a carbamic acid;R.sub.1 is a substituent selected from an aliphatic hydrocarbon radical, an araliphatic hydrocarbon radical and a cycloaliphatic hydrocarbon radical;X.sub.1 and X.sub.3, independently of one another, are oxygen (--O--) or sulphur (--S--); andX.sub.
    Type: Grant
    Filed: September 17, 1992
    Date of Patent: September 21, 1993
    Assignee: Ciba-Geigy
    Inventor: Alan J. Main
  • Patent number: 5245075
    Abstract: Amino-derivative (poly)peroxycarboxylic acids which have the formula: ##STR1## wherein the symbols have the following meanings: R, R.sub.1, and R.sub.2, which may be equal to or different from one another, represent hydrogen atoms, alkyl groups or groups selected from R, R.sub.1 and R.sub.2, which taken together with the nitrogen atom to which they are linked, give rise to an aliphatic heterocyclic group, all of them being optionally substituted;A represents a (cyclo) alkylene group, an arylene group which may also be condensed with cycloaliphatic groups, a cycloalkylene-alkylene or an alkylene-cycloalkylene group, an arylene-alkylene or an alkylene-arylene group, which may be condensed with cyclo-aliphatic groups wherein said alkylene group may also be interrupted by --CONR.sub.3 groups, wherein R.sub.3 represents a hydrogen atom or an alkyl or aryl group;X.sup.- represents HSO.sub.4.sup.- or CH.sub.3 SO.sub.3.sup.- ; a process for their preparation; and their use as bleaching agents.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: September 14, 1993
    Assignee: Ausimont S.r.l.
    Inventors: Carlo Venturello, Claudio Cavallotti
  • Patent number: 5166416
    Abstract: The invention relates to new propenone oxime ethers, a method of preparing them and pharmaceutical compositions containing them.Said new propenone oxime ethers have the formula ##STR1## in which--Ar and Ar' each independentlyl denotes a phenyl group non-substituted, mono or polysubstituted, a 9-anthryl group or a naphthyl group, a pyridyl, thienyl or furyl group;R.sub.1 R.sub.2 each independently denotes hydrogen, a C.sub.1 -C.sub.4 alkyl group or together with the N-atom to which they are bonded a 1-pyrrolidinyl, piperidino, morpholino or 1-piperazinyl group;M=H, Cl, Br or a C.sub.1 -C.sub.6 alkyl groupn=2 or 3.The invention also deals with the salts of compounds of formula (I). Said compounds have good activity in the anti platelet-clotting tests and are also antagonists of the 5HT.sub.2 receptors.
    Type: Grant
    Filed: December 1, 1989
    Date of Patent: November 24, 1992
    Assignee: Societe Anonyme: Sanofi
    Inventors: Christian Congy, Patrick Gueule, Bernard Labeeuw, Murielle Rinaldi
  • Patent number: 5068405
    Abstract: Halogenated N-sulfamyl propionamidine addition salts corresponding to the formula ##STR1## are provided, in which X represents halogen and A represents an acid selected from sulfuric acid, nitric acid, benzenesulfonic acid; toluenesulfonic acid; 2,4,5-trichlorobenzenesulfonic acid; trichloroacetic acid; trifluoroacetic acid or methanesulfonic acid. They are useful as intermediates in the preparation of famotidine. They are prepared by reacting a halogenated propionitrile with the respective acid.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: November 26, 1991
    Assignee: Delmar Chemicals Inc.
    Inventors: Michel Bekhazi, Josef Oren
  • Patent number: 5053531
    Abstract: Described are certain quaternary ammonium alkyl benzene sulfonate salts and certain quaternary ammonium alkane sulfonate salts, e.g., octyl dimethyl hydroxyethyl ammonium dodecyl benzene sulfonate and octyl dimethyl hydroxyethyl ammonium methane sulfonate which are useful as antistatic agents for synthetic polymer articles.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: October 1, 1991
    Assignee: PPG Industries, Inc.
    Inventor: Cheruthur Govindan
  • Patent number: RE44032
    Abstract: Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS 2-acrylamido-2-methyl-1-propanesulfonic acid-ammonium salt polymer is accomplished by adding 2,2?-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: February 26, 2013
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Holly L. Ricks-Laskoski, Arthur W Snow
  • Patent number: RE44988
    Abstract: Disclosed is a new ionic liquid monomer salt and methods of is synthesis and polymerization. The ionic liquid monomer salt is prepared by mixing equimolar amounts of an amine, such as tris[2-(2-methoxyethoxy)-ethyl]amine and an acid functionalized polymerizable monomer, such as 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), which is stirred at ambient temperature until salt formation is complete. Also disclosed is a new ionic liquid polymer salts and method for making the same. The synthesis of AMPS-ammonium salt polymer is accomplished by adding 2,2?-azobisisobutyronitrile (AIBN) to the ionic liquid monomer salt and heating the homogeneous melt at 70° C. for 18 hr.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: July 1, 2014
    Assignee: The United States of America, as represented by the Secretary of the Navy
    Inventors: Holly L. Ricks-Laskoski, Arthur W. Snow