Cyclopentyl Bonded To -coor, -ccoor, Or -cccoor Patents (Class 562/504)
  • 1-Hydroxymethyl-1-oxo-prostane derivatives of the E.sub.2 series
    Patent number: 4170597
    Abstract: Derivatives, analogs, and congeners of prostane having a 1-(hydroxymethyl)-1-oxo-prostane structure in the E.sub.2 series.
    Type: Grant
    Filed: December 8, 1977
    Date of Patent: October 9, 1979
    Assignee: American Cyanamid Company
    Inventor: Allan Wissner
  • Prostaglandin intermediates
    Patent number: 4154963
    Abstract: Process for synthesizing the lactone, (dl) 3,3a beta-4,5-6,6a beta-hexahydro-4beta(3-hydroxyl-1-trans-octenyl)-5alpha-hydroxy-2-oxo-2H-c yclopenta[b]furan, a known intermediate for producing prostaglandin E.sub.2 and F.sub.2.alpha. and a process for preparing 11-desoxy and 11-alkyl prostaglandins from dihydroresorcyclic acid.
    Type: Grant
    Filed: February 23, 1978
    Date of Patent: May 15, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Frank Kienzle, Perry Rosen
  • Cyclopentone propanoic acid compounds
    Patent number: 4151199
    Abstract: Propanoic acid derivatives of the formula: ##STR1## where R.sup.1 is a C.sub.1-8 alkyl group optionally substituted by hydroxyl or --COOH and R.sup.2 is hydrogen or a protecting group, are useful as anti-thrombotic agents.
    Type: Grant
    Filed: December 4, 1975
    Date of Patent: April 24, 1979
    Assignee: Lilly Industries Limited
    Inventors: William Dawson, Michael J. Foulis, Norman J. A. Gutteridge, Colin W. Smith
  • Manufacture of 2-(alkyl, alkenyl or alkynyl) 3-carbalkoxyalkyl ketones from alpha, beta-unsaturated ketones
    Patent number: 4143230
    Abstract: The copper enolate of 3-allylcyclopentanone is alkylated with an alkyne so as to form the 2-alkynyl, 3-allylcyclopentanone which is then subjected to ozonolysis and oxidative cleavage to form 2-alkynylcyclopentan-3-one-1-yl alkylcarboxlic acid. The acid can be esterified to form a 2-alkynyl-3-carbalkoxyalkyl ketone which, in turn, can be hydrogenated to convert the alkynyl moiety to alkenyl or alkyl moieties. The procedure is particularly useful in the synthesis of methyl dl-jasmonate, dehydrojasminate and dihydrojasmonate.
    Type: Grant
    Filed: October 28, 1976
    Date of Patent: March 6, 1979
    Assignee: CHON Corporation
    Inventors: Andrew E. Greene, Pierre Crabbe
  • Asymmetric synthesis of optically active prostaglandins
    Patent number: 4140708
    Abstract: An asymmetric synthesis of optically active prostaglandin F.sub.2.alpha. from cyclopentadiene including intermediates in this synthesis.
    Type: Grant
    Filed: September 19, 1977
    Date of Patent: February 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Naresh K. Chadha, John J. Partridge, Jr., Milan R. Uskokovic
  • Cobalt-catalyzed oxidation of hydrocarbons
    Patent number: 4131742
    Abstract: A process for the liquid phase oxidation of hydrocarbons with a molecular oxygen-containing gas in the presence of a dissolved cobalt salt catalyst characterized in that the oxidation is carried out in the substantial absence of chromium in the reaction medium i.e. a concentration of chromium in the liquid phase of not greater than 400 ppm.
    Type: Grant
    Filed: November 3, 1976
    Date of Patent: December 26, 1978
    Assignee: BP Chemicals Limited
    Inventor: Barry Hudson
  • Process for preparation of organic carboxylic acids
    Patent number: RE29981
    Abstract: A process for the preparation of organic carboxylic acids which comprises converting a formic acid ester expressed by the general formulaHCOORwherein R stands for a chain or cyclic aliphatic hydrocarbon radical which may have an aliphatic unsaturation, an aryl radical, an aralkyl radical or a heterocyclic radical,At an elevated temperature under raised pressure of carbon monixide to an organic carboxylic acid expressed by the general formulaRCOOHwherein R is as defined above.
    Type: Grant
    Filed: July 22, 1977
    Date of Patent: May 1, 1979
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventor: Nobuo Isogai