Carboxylic Acids And Salts Thereof Patents (Class 562/400)
  • Patent number: 9603816
    Abstract: The present invention relates to a process for the preparation of S-[2-[1-(2 -ethylbutyl)cyclohexylcarbonylamino]-phenyl] 2-methylthiopropionate which is useful as a pharmaceutically active compound.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: March 28, 2017
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans-Juergen Mair, Reinhard Reents, Michelangelo Scalone, Shaoning Wang, Andreas Zogg
  • Patent number: 9145302
    Abstract: Disclosed are methods for preparing pure graphene using chemical bonding between graphite oxide and metal oxide nanoparticles, and graphene and nanoparticles having a quasi metal oxide-graphene core-shell prepared therefrom. The disclosed methods for preparing graphene allow chemical bonding and separation through a simple acid treatment process using inexpensive materials. Also, because the reaction can be carried out at low temperature, the processing cost is low. And, pure graphene with few impurities can be prepared quickly in large scale.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: September 29, 2015
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Won Kook Choi, Dong Hee Park, Byoung Wook Kwon, Dong Ick Son
  • Patent number: 9029289
    Abstract: The present invention relates to a catalyst for preparing carboxylic acids and/or carboxylic anhydrides, which has a plurality of catalyst zones arranged in series and has been produced using a vanadium antimonate having a maximum content of crystalline valentinite of 5% by weight. The present invention further relates to a process for gas-phase oxidation in which a gas stream comprising at least one hydrocarbon and molecular oxygen is passed through a catalyst which has a plurality of catalyst zones arranged in series and has been produced using a vanadium antimonate having a maximum content of crystalline valentinite of 5% by weight.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: May 12, 2015
    Assignee: BASF SE
    Inventors: Michael Krämer, Jürgen Zühlke, Stefan Altwasser, Nico Frederik Fischer, Frank Rosowski, Hans-Martin Allmann
  • Patent number: 9023584
    Abstract: A radiation-sensitive composition includes a compound represented by a formula (1), and a polymer having a structural unit that includes an acid-labile group. In the formula (1), R1 represents a group having a polar group; n is an integer of 1 to 4, wherein, in a case where R1 is present in a plurality of number, the plurality of R1s are identical or different, and optionally at least two R1s taken together represent a cyclic structure; A represents an alicyclic hydrocarbon group having a valency of (n+1); and M+ represents a monovalent onium cation.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: May 5, 2015
    Assignee: JSR Corporation
    Inventor: Ken Maruyama
  • Patent number: 9018414
    Abstract: The present application relates to novel 3-phenylpropionic acid derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: April 28, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Thomas Lampe, Michael Hahn, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Frank Wunder, Sherif El Sheikh, Volkhart Min-Jian Li, Eva-Maria Becker-Pelster, Friederike Stoll, Andreas Knorr
  • Patent number: 9012505
    Abstract: The present invention relates to novel antimicrobial compounds, methods of their production as well as uses thereof.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: April 21, 2015
    Assignee: Agency for Science, Technology and Research
    Inventors: Lianhui Zhang, Yinyue Deng, Jien Wu
  • Patent number: 8993819
    Abstract: The present invention provides a process for preparing cycloheptene and derivatives thereof by ring-closing metathesis of unsymmetric 1,8-dienes whose C—C double bond at the 8 position is nonterminal. Cycloheptene and the cycloheptanone, cycloheptylamine, cycloheptanecarbaldehyde, cycloheptanecarboxylic acid and cycloheptanecarbonyl chloride conversion products thereof, and the derivatives thereof, are important synthesis units for active ingredient compounds. The ring-closing metathesis is preferably performed as a reactive distillation. The unsymmetric 1,8-dienes for the ring-closing metathesis can be obtained by catalytic decarbonylation or oxidative decarboxylation from the corresponding unsaturated carboxylic acids or carboxylic acid derivatives.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: March 31, 2015
    Assignee: BASF SE
    Inventors: Joaquim Henrique Teles, Michael Limbach, Richard Dehn, Stephan Deuerlein, Manuel Danz
  • Publication number: 20150087031
    Abstract: The present invention relates to methods of processing lignocellulosic material to obtain hemicellulose sugars, cellulose sugars, lignin, cellulose and other high-value products. Also provided are hemicellulose sugars, cellulose sugars, lignin, cellulose, and other high-value products.
    Type: Application
    Filed: May 3, 2013
    Publication date: March 26, 2015
    Inventors: Robert Jansen, Claire Gregoire, philip Travisano, Lee Madsen, Neta Matis, Yael Har-Tal, Shay Eliahu, James Alan Lawson, Noa Lapidot, Luke Burke, Aharon M. Eyal, Timothy Allen Bauer, Hagit Sade, Paul Mcwilliams, Ziv-Vladimir Belman, Bassem Hallac, Michael Zviely, Yelena Gershinksy, Adam Carden
  • Patent number: 8981148
    Abstract: An esteramide compound of the following formula (I): R1OOC-A-CONR2R3??(I) is described, wherein: A is a covalent bond or a methylene group —CH2—; R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms, R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, and R2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.
    Type: Grant
    Filed: March 17, 2011
    Date of Patent: March 17, 2015
    Assignee: Rhodia Operations
    Inventors: Massimo Guglieri, Thierry Vidal
  • Patent number: 8969554
    Abstract: Disclosed are compounds exhibiting sufficient herbicidal activity at low application dosage when they are applied to soils and foliage, and an agrochemical composition using the same, in particular herbicides. The compounds are triazine derivatives represented by following Formula 1 or salts thereof, and the herbicides containing them: [Chem. 28] wherein in the formula, R1 represents a hydrogen atom; a C1-C12 alkyl group; a C2-C6 alkenyl group, etc., R2 represents a C1-C12 alkyl group, etc., Y and Z represent an oxygen atom or a sulfur atom, and A represents a 5- or 6-membered cyclic group which may contain a nitrogen atom, an oxygen atom, or a sulfur atom.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 3, 2015
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Atsushi Shibayama, Ryu Kajiki, Masami Kobayashi, Takashi Mitsunari, Atsushi Nagamatsu
  • Publication number: 20150030744
    Abstract: The presently disclosed subject matter is directed to novel compounds of Formula I, Formula II, and Formula III, and stereoisomers thereof, and flavor compositions comprising the novel compounds.
    Type: Application
    Filed: August 31, 2012
    Publication date: January 29, 2015
    Applicant: Takasago International Corp. (USA)
    Inventors: Louis J. Lombardo, Michael E. Lankin, Jaime M. Ferreira, Jennifer B. Tartaglia, John D. Zanone, Amrit Mankoo
  • Publication number: 20150018368
    Abstract: The present invention discloses process for preparing benzisothiazol-3-yl-piperazin-1-yl-methyl-cyclo hexyl-methan-isoindol-1,3-dione and intermediates thereof.
    Type: Application
    Filed: February 12, 2013
    Publication date: January 15, 2015
    Inventors: Shri Prakash Dhar Dwivedi, Ramesh Chandra Singh, Rajendra Gokalbhai Chavda
  • Patent number: 8927002
    Abstract: The invention relates to a stent with in particular a coated basic body made of an implant material the use of lithium salts as a coating material or a component of an implant material for stents and the use of lithium salts in a method for restenosis prevention. The inventive stent having a basic body made of an implant material is characterized in that (i) the basic body has a coating which comprises or consists of a lithium salt, and/or (ii) the implant material is biocorrodible and the basic body contains a lithium salt.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: January 6, 2015
    Assignee: Biotronik VI Patent AG
    Inventor: Eric Wittchow
  • Patent number: 8920830
    Abstract: The present invention relates to wound dressings having a wound contacting layer that contains a wound healing composition and which is adapted to maintain a temperature different from ambient, for example achieve and maintain a heat-absorbing effect on the underlying tissues. The specific physico-chemical structure of the devices of the invention allows fluid containment and absorption of wound secretions while avoiding skin macerations.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: December 30, 2014
    Assignee: Laboratoire Medidom S.A.
    Inventor: Burkhard Mathies
  • Patent number: 8912186
    Abstract: The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: December 16, 2014
    Assignee: Universitaet des Saarlandes
    Inventors: Matthias Engel, Wolfgang Fröhner, Adriane Stroba, Ricardo M. Biondi
  • Publication number: 20140343289
    Abstract: The problem to be solved by the present invention is to ea lily and efficiently produce an amino acid having 2 to 7 carbon atoms as a high-purity solid without complicated operation, which is useful as a synthetic intermediate for medicines or agrochemicals. The present invention is characterized in comprising a step of precipitating solid amino acid with high purity. In the present invention, the by-produced salt composed of the sulfonic acid and the amine was removed to the mother liquor by reacting an amine with a sulfonic acid salt of amino acid in an aprotic polar solvent, or by reacting a sulfonic acid with an amine salt of amino acid in an aprotic polar solvent. The sulfonic acid salt of amino acid, for example, may be produced by reacting a N-(tert-butoxycarbonyl) amino acid with a sulfonic acid, or by reacting an amino acid tert-butyl ester with a sulfonic acid.
    Type: Application
    Filed: January 21, 2013
    Publication date: November 20, 2014
    Applicant: Kaneka Corporation
    Inventors: Masatoshi Ohnuki, Akira Nishiyama
  • Publication number: 20140336403
    Abstract: A process for the preparation of a compound of formula (I): which is useful as an intermediate in the preparation of pharmaceutically active compounds.
    Type: Application
    Filed: July 25, 2014
    Publication date: November 13, 2014
    Inventors: Gerard John Harnett, John Hayes, Reinhard Reents, Dennis A. Smith, Andrew Walsh
  • Patent number: 8865935
    Abstract: The present invention provides a method of purifying betulonic acid contained the reaction product of organic synthesis of a Jones oxidation reagent and betulin extracted from the bark of a birch, a method of preparing a piperazine betulonic acid amide derivative, which is used as a chemical having an antibacterial function, using the high-purity betulonic acid obtained by the purification method and a derivative prepared by this method, a method of purifying a Boc-lysinated betulonic acid monomer ester contained in the reaction product of organic synthesis of lysine and the high-purity betulonic acid (starting material) obtained by the purification method, and a method of purifying Boc-lysinated betulonic acid contained in the reaction product of hydrolysis of the high-purity Boc-lysinated betulonic acid monomer ester.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: October 21, 2014
    Assignee: Korea Institute of Energy Research
    Inventors: Kuck-Tack Chue, Tae-Hwan Kim, Leonid Ten
  • Publication number: 20140288210
    Abstract: A resin composition includes a resin selected from a polylactic acid resin and a polycarbonate resin as a matrix resin, and surface-treated red phosphorus, wherein the surface-treated red phosphorus is contained in an amount of 10 parts by weight to 40 parts by weight, based on 100 parts by weight of the polylactic acid resin or the polycarbonate resin.
    Type: Application
    Filed: October 18, 2013
    Publication date: September 25, 2014
    Applicant: FUJI XEROX CO., LTD.
    Inventor: Akira IMADA
  • Publication number: 20140273108
    Abstract: A method of producing hydrolysate from cellulosic material by adding hydrothermally treated stillage or a fraction thereof to cellulosic material, treating the mixture of hydrothermally treated stillage and cellulosic material with at least one hydrolyzing enzyme, and hydrolyzing and converting complex carbohydrates in the cellulosic material. The hydrolysate produced by the method. Ethanol, organic acids, and organism metabolites produced by the method. Biomass produced by the method. A method of increasing sugar production rate and yield of sugars from cellulosic material by adding hydrothermally treated stillage or a fraction thereof to cellulosic material, treating the mixture of hydrothermally treated stillage and cellulosic material with at least one hydrolyzing enzyme, and hydrolyzing complex carbohydrates in the cellulosic material and forming sugars.
    Type: Application
    Filed: March 17, 2014
    Publication date: September 18, 2014
    Applicant: Valicor, Inc
    Inventor: James Robert Bleyer
  • Patent number: 8835377
    Abstract: Bioavailability of peptide active agents to be administered orally is enhanced by a pharmaceutical composition providing targeted release of the peptide to the intestine by combining the composition with an absorption enhancer. Bioavailability is further significantly increased by administering the composition in an acid-resistant protective vehicle which transports components of the invention through the stomach. The composition may optionally further include a sufficient amount of a pH-lowering agent to lower local intestinal pH. All components are released together into the intestine with the peptide.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: September 16, 2014
    Assignee: UGP Therapeutics, Inc.
    Inventors: Nozer M. Mehta, William Stern, James P. Gilligan
  • Publication number: 20140242867
    Abstract: Lignin compositions, products produced from them or containing them, methods to produce them, spinning methods, methods to convert lignin to a conversion product and conversion products produced by the methods are described.
    Type: Application
    Filed: April 4, 2012
    Publication date: August 28, 2014
    Inventors: Robert Jansen, Aharon Eyal, Noa Lapidot, Bassem Hallac, Ziv-Vladimir Belman, Shmuel Kenig
  • Patent number: 8809578
    Abstract: The present invention relates to a novel compound having excellent antioxidant activity, isolated from Ramalina terebrata, and more particularly to a novel compound, RAMALIN™, having excellent antioxidant activity, isolated from the Antarctic lichen Ramalina terebrata, a method for preparing the RAMALIN™, and a pharmaceutical composition, a functional food and a functional cosmetic composition, which contain the RAMALIN™ as an active ingredient. The RAMALIN™ according to the invention has significantly excellent antioxidant effects compared to commercially available antioxidants, and thus can be widely used in agents for treating oxidation-related diseases, anti-aging functional foods, functional cosmetic products for skin whitening and wrinkle reduction, etc.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: August 19, 2014
    Assignee: Korea Ocean Research and Development Institute
    Inventors: Joung Han Yim, Hong Kum Lee, Hari Datta Bhattarai, Paudel Babita, Il Chan Kim, Soon Gyu Hong, Doc Kyu Kim, Yoo Kyung Lee, Sung Gu Lee, Hyun Cheol Oh
  • Patent number: 8802893
    Abstract: According to a method for producing acetic acid by carbonylation of methanol characterized in that an acid having an acid dissociation constant (pKa) smaller than the constant of acetic acid is allowed to be present in the reaction system, acetic acid can be produced by the reaction of methanol and carbon monoxide in a reaction liquid in the presence of a solid catalyst containing rhodium and alkyl iodide, to achieve an enhanced reaction rate of carbonylation of methanol in producing acetic acid in the region at a high carbonylation degree (Ca>0.8 mol/mol) for more efficient production of acetic acid.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 12, 2014
    Assignee: Chiyoda Corporation
    Inventors: Zhixiong You, Takeshi Minami, Chunji Yin, Yoichi Umehara, Tetsuro Matsumura, Chikako Hashimoto, Yasuo Hosono
  • Patent number: 8791159
    Abstract: A compound having an ability to bind to an SIP receptor and represented by formula (I), a salt thereof, a solvate thereof or a prodrug thereof is useful for prevention and/or treatment of rejection of transplantation, graft-versus-host disease, autoimmune disease, allergic disease and the like: wherein ring A is a cyclic group; ring B is a cyclic group which may have substituent(s); X is a spacer having 1 to 8 atoms in its main chain, etc.; Y is a spacer having 1 to 10 atoms in its main chain, etc.; n is 0 or 1, wherein when n is 0, m is 1 and R1 is a hydrogen atom or a substituent, and wherein when n is 1, m is 0 or an integer of 1 to 7 and R1 is a substituent, and wherein m is 2 or more, R1s are the same or different.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: July 29, 2014
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shinji Nakade, Hirotaka Mizuno, Takeji Ono, Masashi Minami, Hiroshi Saga, Hiroshi Hagiya, Takaki Komiya, Hiromu Habashita, Haruto Kurata, Kazuhiro Ohtsuki, Kensuke Kusumi
  • Patent number: 8791049
    Abstract: Provided are improved agricultural processes for the improved cultivation of rice wherein the crops are treated to control undesired vegetative growth using a plant treatment composition comprising both halosulfuron and thifensulfuron to provide improved herbicidal efficacy against Heteranthera limosa, commonly referred to as “duck salad”. Also provided are compositions useful in the improved agricultural processes, as well as herbicidal treatment regimens. Unexpectedly high rates of efficacy against Heteranthera limosa, amongst rice plant in rice crops are disclosed.
    Type: Grant
    Filed: December 13, 2010
    Date of Patent: July 29, 2014
    Assignee: Gowan Co.
    Inventors: Eric Paige Webster, Dominic Frank Alonso, Sergio Comparini, Wallace Keith Majure, Sandra Alcaraz, Charles Paul Grasso, Eric James McEwen, Tak Wai Cheung
  • Patent number: 8785680
    Abstract: The present invention relates to novel antimicrobial compounds, methods of their production as well as uses thereof.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: July 22, 2014
    Assignee: Agency for Science, Technology and Research
    Inventors: Lianhui Zhang, Yinyue Deng, Jien Wu
  • Patent number: 8778840
    Abstract: The present invention relates to novel soluble liquid (SL) formulations comprising A) quinclorac ammonium salts of formula I wherein R1, R2, R3 and R4 are independently hydrogen or optionally substituted alkyl, and B) a solvents of formula IIa wherein R5 is alkyl; A is alkylene or oxyalkylene; and m is 0, 1, 2 or 3; and/or a solvent of formula IIb HO—B—OH??(IIb) wherein B is a straight-chain or branched alkylene or alkyleneoxyalkylene or alkyleneoxyalkyleneoxyalkylene.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: July 15, 2014
    Assignee: BASF SE
    Inventors: Rainer Berghaus, Terrance Cannan, Joseph Zawierucha, Glenn W. Oliver
  • Publication number: 20140194651
    Abstract: Disclosed are compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by artificial sweeteners including aspartame, saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate; and including stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A.
    Type: Application
    Filed: March 29, 2013
    Publication date: July 10, 2014
    Applicant: GIVAUDAN S.A.
    Inventors: Ioana Maria UNGUREANU, Nicole Erna Irene BRUNE, Jay Patrick SLACK, Kimberley GRAY, Christopher Todd SIMONS, Jenny Ellen EVANS PENNIMPEDE
  • Publication number: 20140186272
    Abstract: The present invention provides synthetic routes for preparing various isomers of cyclohexane-based coolants, such as menthyl esters and menthanecarboxamide derivatives, in particular those substituted at the amide nitrogen, for example with an aromatic ring or aryl moiety. Such structures have high cooling potency and long lasting sensory effect, which make them useful in a wide variety of consumer products. One synthetic route involves a copper catalyzed coupling of a primary menthanecarboxamide with an aryl halide, such reaction working best in the presence of potassium phosphate and water. Using this synthetic route, specific isomers can be prepared including the menthanecarboxamide isomer having the same configuration as l-menthol and new isomers such as a neoisomer having opposite stereochemistry at the carboxamide (C-1) position. The neoisomer unexpectedly has potent and long lasting cooling effect.
    Type: Application
    Filed: March 5, 2014
    Publication date: July 3, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Kenneth Edward YELM, Gregory Mark BUNKE, John Christian HAUGHT
  • Patent number: 8742005
    Abstract: The present invention relates to an acrylate-based compound that includes an organic acid having two or more acrylate groups and one or more phenolic acid structures in one molecule, and a photosensitive composition including the same. It is possible to shorten a developing time in a photolithography process without damaging photosensitivity by using the photosensitive composition according to the present invention.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: June 3, 2014
    Assignee: LG Chem, Ltd.
    Inventors: Keon Woo Lee, Sang Kyu Kwak, Changsoon Lee, Hyehyeon Kim
  • Patent number: 8710261
    Abstract: The present invention relates to Compounds having the structure of Formula I: wherein n is an integer from 1 to 5; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, alkoxy, aryloxy, alkenyloxy or alkynyloxy; R2 is alkenyl, allcynyl, aryl, heterocyclyl, heteroaryl, cycloalkyl, NR4R5, —NHC(?Y)R4, —NHC(?Y)NR5R?, —NHC(?O)OR4, —NHSO2R4, C(?Y)NR4R5, C(?O)OR6 [wherein Y is oxygen or sulphur], OR5, —O(C?O)NR4R5, O-acyl, S(O)mR4, —SO2N(R4)2, cyano, amidino or guanidino [wherein R4 is alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl and m is an integer 0-2; R5 is hydrogen or R4; Rx is R4 or —SO2N(R4)2 and R6 is hydrogen, alkyl, cycloalkyl, aralkyl, heteroarylalkyl, heterocyclylalkyl or cycloalkylalkyl]; R3 is hydrogen, fluorine, alkyl, cycloalkylalkyl or aralkyl; A is OH, OR4, —OC(?O)NR4R5, O-acyl, NH2, NR4R5, —NHC(?Y)R4, —NHC(?Y)NR5Rx, —NHC(?O)OR4, —NHSO2R4, and to processes for t
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: April 29, 2014
    Assignee: Ranbaxy Laboratories Limited
    Inventors: Venkata P. Palle, Viswajanani Jitendra Sattigeri, Manoj Kumar Khera, Sreedhara Rao Voleti, Abhijit Ray, Sunanda G. Dastidar
  • Patent number: 8703183
    Abstract: The present invention relates to metformin glycinate salt and pharmaceutical compositions thereof for the treatment of diabetes mellitus. The method includes administration of the metformin glycinate salt by various routes selected from oral, intravenous injectable, intramuscular injectable, nasal, intraperitoneal, or sublingual, in order to achieve a reduction in blood glucose levels. The invention further relates to the synthesis of a new 1,1-dimethylbiguanide glycinate salt, called Metformin Glycinate. The resulting salt exhibits advantages over other metformin salts. These advantages are due, in the first place, to the fact that the glycine counterion exhibits hypoglycemic effects by itself. Moreover, the salt exhibits more rapid absorption, reaching higher plasma concentrations than those produced with metformin hydrochloride.
    Type: Grant
    Filed: December 24, 2010
    Date of Patent: April 22, 2014
    Assignee: Laboratorios Silanes S.A. de C.V.
    Inventor: Jose Manuel FranciscoOchoa Lara
  • Patent number: 8703108
    Abstract: Cleansing compositions include a mixture of alkyl ether carboxylic acids and/or salts thereof, each having a structure according to formula (1): R1—O—(CH2CH2O)n—CH2—COOM??(1) where R1 is an alkyl group having 4 to 22 carbon atoms, n is a number of from 0 to 20, and M is a hydrogen atom, alkali metal, alkaline earth metal, ammonium, or organic ammonium. The mixture includes alkyl ether carboxylic acids and/or salts having at least two different alkyl groups R1, an average carbon number of alkyl groups R1 of alkyl ether carboxylic acids and/or salts in the mixture is from 10.8 to 12.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: April 22, 2014
    Assignee: Kao Corporation
    Inventors: Hiroki Takeuchi, Masahiro Miyaki, Naoko Yamamoto, Natsuko Toshida, Jurgen Benade
  • Patent number: 8691069
    Abstract: The present disclosure is a system and method for producing a first product from a first region of an electrochemical cell having a cathode and a second product from a second region of the electrochemical cell having an anode. The method may include a step of contacting the first region with a catholyte including carbon dioxide and contacting the second region with an anolyte including a recycled reactant. The method may further include applying an electrical potential between the anode and the cathode sufficient to produce carbon monoxide recoverable from the first region and a halogen recoverable from the second region.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: April 8, 2014
    Assignee: Liquid Light, Inc.
    Inventors: Kyle Teamey, Jerry J. Kaczur, Robert Page Shirtum
  • Patent number: 8680324
    Abstract: The invention relates to a process for recovering sterols and fatty and/or resin acids from tall oil pitch, comprising the steps of: a) saponifying tall oil pitch to provide saponified tall oil pitch, b) drying the saponified pitch to obtain dried saponified pitch, c) subjecting the dried saponified pitch to a first high vacuum evaporation to obtain an unsaponifiable fraction as a distillate and a first residue, d) optionally subjecting said distillate to a second high vacuum evaporation to obtain an enriched unsaponifiable fraction, e) crystallizing sterols from the unsaponifiable fraction or the enriched unsaponifiable fraction, f) acidulating the first residue obtained in step c) to obtain an aqueous phase and an organic phase, separating the aqueous phase and drying the organic phase to obtain a dried organic phase, and g) subjecting the dried organic phase to vacuum distillation to obtain fatty and/or resin acids and a second residue, said process additionally comprising providing pitch-based heavy com
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: March 25, 2014
    Assignee: Raisio Nutrition Ltd.
    Inventors: Antti Hamunen, Juha Orte, Reino Kalmari, Kosti Mokkila, Marianne Kallio-Meriluoto
  • Patent number: 8669210
    Abstract: This invention relates to a high-strength, aqueous herbicidal concentrate containing the clopyralid dimethylamine salt. The formulation is stable to storage and exhibits lower viscosity than other clopyralid amine salt formulations.
    Type: Grant
    Filed: March 21, 2011
    Date of Patent: March 11, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventor: Robert M. Buttimor
  • Patent number: 8669209
    Abstract: Soluble granule formulations of amine salts of pyridine containing carboxylic acids with improved handling properties are provided by an improved process in which the pyridine containing carboxylic acid is partially neutralized with an amine.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: March 11, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Franklin N. Keeney, Neil A. Foster, Martin C. Logan, Maria G. Perry
  • Patent number: 8653138
    Abstract: The present invention relates to calcium salts of compounds of the general formula (I) wherein X is selected from the group consisting of CH2, S, or O; D is O or S; R8 is hydrogen or alkyl; E is an optionally substituted phenylene group; Y is a monocyclic or bicyclic substituted or unsubstituted 6-9 membered ring system which may contain one or more heteroatoms selected from N or S and which contains at least one aromatic ring; n is 0 or 1, and q is 0 or 1; with the proviso that compounds wherein X?CH2, q=0, Y=unsubstituted phenyl and E=unsubstituted phenylene are excluded; or a hydrate thereof.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: February 18, 2014
    Assignee: 4SC MG
    Inventors: Aldo Ammendola, Julia Diederichs, Johann Leban, Daniel Vitt
  • Publication number: 20140046000
    Abstract: A method of accelerating a curing process in resin overflow systems for use in casting processes includes the step of adding a curing accelerator for the resin into the resin overflow system. In addition, a resin overflow container and a compartment with a curing accelerator for use in casting processes are provided.
    Type: Application
    Filed: July 25, 2013
    Publication date: February 13, 2014
    Inventors: Martin Jensen, Simon Kwiatkowski Pedersen
  • Patent number: 8642635
    Abstract: The present invention provides a compound of formula I; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R6, A1, A2, X1, s and m are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: February 4, 2014
    Assignee: Novartis AG
    Inventors: Yuki Iwaki, Toshio Kawanami, Gary Michael Ksander, Muneto Mogi
  • Patent number: 8637496
    Abstract: The invention relates to the use of compounds having a monogalactosyldiacylglycerol (MGDG) synthase inhibitory activity as herbicide or algaecide, and to herbicide and algaecide compositions containing at least one of these compounds.
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: January 28, 2014
    Assignees: Commissariat a l'Energie Atomique, Centre National de la Recherche Scientifique
    Inventors: Anne-Laure Bonneau, Cyrille Botte, Michael Deligny, Nadia Saidani, Hélène Hardre, Bernard Rousseau, Roman Lopez, Eric Marechal
  • Patent number: 8632758
    Abstract: An aqueous hair cleansing agent contains a sulfate-type anionic surfactant having a specific structure, an ether carboxylate-type anionic surfactant having a specific structure, and an organic carboxylic acid or salt thereof, thereby has a pH of 1 to 5 at 25° C. when diluted 20-fold with water.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: January 21, 2014
    Assignee: Kao Corporation
    Inventor: Eiji Terada
  • Publication number: 20140011903
    Abstract: In various embodiments a urethane/molecular rebar formulation comprising a specific composition is disclosed. The composition comprises a urethane polymer or prepolymer/discrete carbon nanotube formulation. Utility of the urethane/molecular rebar composition includes improved foams and adhesives.
    Type: Application
    Filed: July 8, 2013
    Publication date: January 9, 2014
    Inventors: Clive P. Bosnyak, Kurt W. Swogger
  • Publication number: 20130326934
    Abstract: Disclosed herein is a process for preparing transportation fuel and optionally a middle distillate, a diesel fuel, a heating oil, a jet fuel, a kerosene, an aviation gasoline, a gasoline fuel, or a lubricant base oil. The process includes the steps of (a) producing a naturally occurring aqueous fluid containing greater than 1 wt. % soluble carboxylic acids; (b) isolating at least a portion of the organic acids from the naturally occurring aqueous fluid; and (c) upgrading the isolated carboxylic acids. The step of upgrading the isolated carboxylic acids can include at least one of hydrotreating, hydrocracking, isomerization, esterification and FCC cracking. The aqueous fluid can then be used in processes for recovery of a mobile kerogen based product. Also disclosed herein is a process for preparing a biofuel comprising the organic acids isolated from naturally occurring aqueous fluid.
    Type: Application
    Filed: June 8, 2012
    Publication date: December 12, 2013
    Applicant: CHEVRON U.S.A. INC.
    Inventors: Marcus Oliver Wigand, Robert Martin CARLSON, Mark Dean LOONEY
  • Patent number: 8604112
    Abstract: The invention relates to a composition containing a particulate solid, a plastic material (such as a thermoplastic polymer) and a compound capable of having dispersant properties. The compound may be obtained/obtainable by reacting a fatty acid with either (i) a hydroxy-C4-5-alkylene carboxylic acid, or (ii) a lactone. The invention further relates to novel compounds, and the use of the compound as a dispersant.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: December 10, 2013
    Assignee: The Lubrizol Corporation
    Inventors: Patrick J. Sunderland, Dean Thetford, Thomas Forder
  • Publication number: 20130323319
    Abstract: The current invention involves the surprising finding that when carboxylated particles, such as carboxylated polystyrene, PLGA, or diamond particles are administered to subjects, inflammatory immune responses are ameliorated. Additionally, the present invention describes methods of treating inflammatory diseases by administering these same carboxylated particles.
    Type: Application
    Filed: November 14, 2011
    Publication date: December 5, 2013
    Applicant: GETTS CONSULTING AND PROJECT MANAGEMENT
    Inventors: Daniel R. Getts, Rachael Terry, Nicholas King
  • Publication number: 20130317238
    Abstract: The present disclosure generally relates to processes, apparatuses and custom catalysts designed to depolymerize a polymer. In one embodiment, the present invention relates to a de-polymerizing apparatus, catalysts and reaction schemes to obtain useful monomers including fuel products by “in situ” reactions using coupled electromagnetic induction.
    Type: Application
    Filed: December 8, 2011
    Publication date: November 28, 2013
    Inventors: Pravansu S. Mohanty, Swaminathan Ramesh
  • Patent number: 8575389
    Abstract: The invention relates to a continuous neutralization process in which at least one ethylenically unsaturated carboxylic acid is neutralized at least partly with a base and the temperature of the neutralized solution is less than 70° C., and also to an apparatus for carrying out the process.
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: November 5, 2013
    Assignee: BASF SE
    Inventors: Matthias Weismantel, Michael de Marco, Dominicus van Esbroeck, Karl J. Possemiers, Ronny De Kaey
  • Publication number: 20130289302
    Abstract: Disclosed are methods for generating propylene glycol, ethylene glycol and other polyols, diols, ketones, aldehydes, carboxylic acids and alcohols from biomass using hydrogen produced from the biomass. The methods involve reacting a portion of an aqueous stream of a biomass feedstock solution over a catalyst under aqueous phase reforming conditions to produce hydrogen, and then reacting the hydrogen and the aqueous feedstock solution over a catalyst to produce propylene glycol, ethylene glycol and the other polyols, diols, ketones, aldehydes, carboxylic acids and alcohols. The disclosed methods can be run at lower temperatures and pressures, and allows for the production of oxygenated hydrocarbons without the need for hydrogen from an external source.
    Type: Application
    Filed: June 25, 2013
    Publication date: October 31, 2013
    Inventor: Randy D. Cortright