Of Carboxylic Acid Ester Patents (Class 564/134)
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Publication number: 20110021820Abstract: The present invention relates to the preparation of compounds of formula (I) derived from arylacetic acid comprising two phenol functions and an amide function, which have free-radical scavenging and antioxidant properties and which are soluble in lipid media. These compounds can be used as cosmetic and pharmaceutical preparations for the prevention of biological degradations caused by free radicals.Type: ApplicationFiled: March 6, 2009Publication date: January 27, 2011Applicant: CATALYS SASInventors: Guy Adrian, Patrick Bigot
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Publication number: 20110009596Abstract: Compounds useful in the preparation of telavancin, for example, were prepared. These compounds include decylaminoethanal dialkyl acetals and N-protected decylaminoethanal dialkyl acetals, imidazolidine derivatives, and N-protected-decylaminoethanal.Type: ApplicationFiled: July 8, 2010Publication date: January 13, 2011Applicant: Plus Chemicals SAInventors: Ettore Bigatti, Deborah Bollini, Augusto Canavesi, Ondrej Simo
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Publication number: 20100298593Abstract: The present invention provides a methoxyimino compound, and a fungicide composition comprising same as an active ingredient. The methoxyimino compound of the present invention, which has an excellent antifungal activity against a wide spectrum of fungi even at a low application rate, can be used to protect various crops.Type: ApplicationFiled: December 5, 2008Publication date: November 25, 2010Applicant: KYUNG NONG CORPORATIONInventors: Joo-Kyung Kim, Hyung-Ho Kim, In-Cheon Hwang, Ho-tae Nam
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Patent number: 7763661Abstract: This invention relates to novel substituted pentafluorosulfanylbenzenes of the formula I: and/or salts thereof as claimed, for use as a synthetic intermediates for preparing medicaments, diagnostic aids, liquid crystals, pesticides, herbicides, fungicides, nematicides, parasiticides, insecticides, acaricides, arthropodicides and polymers.Type: GrantFiled: March 9, 2007Date of Patent: July 27, 2010Assignee: sanofi-aventis Deutschland GmbHInventors: Heinz-Werner Kleemann, Remo Weck
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Patent number: 7754917Abstract: Fluoroalkyl amidoalkyl alcohols of the formula are disclosed and their corresponding (meth)acrylate esters. These fluoroalkyl amidoalkyl (meth)acrylate monomers can be copolymerized with a wide variety of conventional ethylenically unsaturated monomers. The resulting copolymers are useful as water, oil- and grease-proofing agents for paper, textiles and hard surfaces such as masonry and wood.Type: GrantFiled: June 18, 2007Date of Patent: July 13, 2010Assignee: Huntsman International LLCInventor: Shobha Kantamneni
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Patent number: 7723543Abstract: The invention relates to a method for the continuous production of alkyl amino acryl amides by reacting alkyl acrylates with high-boiling amines. A specific preparation technique is used in order to achieve hitherto unobtainable product qualities. Very high spatial, temporal and overall yields can also be obtained.Type: GrantFiled: November 18, 2005Date of Patent: May 25, 2010Assignee: Evonik Roehm GmbHInventors: Volker Schleep, Thomas Mertz
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Publication number: 20090259066Abstract: A method for preparing a prostaglandin F analogue represented by the following formula (I) is disclosed, wherein R1, and are as defined in the specification.Type: ApplicationFiled: July 3, 2008Publication date: October 15, 2009Applicant: Everlight USA, Inc.Inventors: Chi-Hsiang Yao, Chun-Mei Yang, Hou-Hsun Chao, Ge-Ray Lee
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Patent number: 7601869Abstract: The present invention relates to a method for the preparation of Florfenicol from Fluoroamine compound, namely (1R,2S)-1-[4-(methylsulfonyl)phenyl]-2-amino-3-fluoro-1-propanol (II), by reaction with dihaloacetic acid ester in an organic solvent in presence of an inorganic base.Type: GrantFiled: June 12, 2006Date of Patent: October 13, 2009Assignee: Aurobindo Pharma Ltd.Inventors: Mallikarjuna Reddy Karuru, Arun Kumar Gupta, Sivakumaran Meenakshisunderam
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Patent number: 7586004Abstract: The invention relates to a process for continuously preparing alkylamino(meth)acrylamide by reacting methyl (meth)acrylate, ethyl (meth)acrylate or amines having a high boiling point compared to methanol or ethanol. A special workup technique which includes removing water from the amine before entering the reactor allows product qualities which have hitherto not been attained to be achieved. In addition, very high space-time and overall yields can be achieved.Type: GrantFiled: April 13, 2004Date of Patent: September 8, 2009Assignee: Roehm GmbH & Co. KGInventors: Volker Schleep, Thomas Mertz
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Publication number: 20090156855Abstract: Novel crystalline hydrate form of (S)-1-phenylethylammonium (R)-diphenyl-methanesulphinyl-acetate and its use in a process for the preparation of (R)-benzhydrylsulphinylacetamide.Type: ApplicationFiled: November 4, 2008Publication date: June 18, 2009Applicant: DIPHARMA FRANCIS S.R.L.Inventors: Giuseppe Barreca, Pietro Allegrini, Gabriele Razzetti
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Patent number: 7544833Abstract: Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino)caprylic acid.Type: GrantFiled: August 30, 2007Date of Patent: June 9, 2009Assignees: Hoffmann-La Roche Inc., Emisphere Technologies, Inc.Inventors: William Elliott Bay, Joseph Norman Bernadino, George Frederick Klein, Yi Ren, Pingsheng Zhang
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Patent number: 7541493Abstract: The invention relates to a process for preparing modafinil having a defined granulometry which comprises the steps of: a) preparing a solution of DMSAM; b) contacting the solution obtained with NH3 at a predetermined temperature and a predetermined stirring; and c) isolating the modafinil formed, wherein said temperature and said stirring are predetermined in order to obtain said defined granulometry.Type: GrantFiled: May 5, 2004Date of Patent: June 2, 2009Assignee: Cephalon FranceInventor: Sébastien Rose
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Patent number: 7521579Abstract: The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-acetamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula (II), wherein R1 R2 and R3 are as defined above with a ?-hydoxycarboxylic acid ester of the formula (III) or a dioxolanone of the formula (III)a, wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula (I) are important intermediates for a novel group of fungicides derived from mandelic acid amides.Type: GrantFiled: November 15, 2002Date of Patent: April 21, 2009Assignee: Syngenta Crop Protection, Inc.Inventors: Martin Zeller, Dominik Faber, Thomas Vettiger, Clemens Lamberth
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Patent number: 7449603Abstract: Provided is a process for preparing Cinacalcet, (R)-?-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine and intermediates thereof.Type: GrantFiled: April 27, 2007Date of Patent: November 11, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventor: Revital Lifshitz-Liron
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Patent number: 7446225Abstract: The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines of the formula I: and a process for preparing a compound of the formula I and/or the pharmaceutically acceptable salts thereof.Type: GrantFiled: March 9, 2007Date of Patent: November 4, 2008Assignee: Sanofi-aventis Deutschland GmbHInventor: Heinz-Werner Kleeman
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Publication number: 20080249334Abstract: The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological properties it might be use as a composition for skin having excellent anti-aging effect to prevent the sagging of skin and loss of luster.Type: ApplicationFiled: October 18, 2006Publication date: October 9, 2008Applicant: INSTYTUT CHEMII BIOORGANICZNEJ PANInventors: Jan Barciszewski, Leszek Rychlewski, Lech Celewicz, Krzysztof Ciszewski, Eliza Wyszko, Katarzyna Rolle
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Publication number: 20080249310Abstract: The invention relates to a novel compound (2R,3R)-2-hydroxy-3-amino-3-aryl-propionamide according to formula (1), wherein aryl A represents a substituted or unsubstituted aromatic ring, and to a process for the preparation of said compound of formula (1), wherein a reaction mixture comprising the two enantiomers (2R,3S) and (2S,3R) of trans-3-aryl glycidic acid alkyl ester and the two enantiomers (2R,3R) and (2S,3S) of cis-3-aryl glycidic acid alkyl ester, said mixture being enantiomerically and diastereomerically enriched in the (2R,3S)-trans-3-arylglycidic acid alkyl ester, is reacted with ammonia. The invention further relates to a process for the preparation of (2R,3R)-2-hydroxy-3 amino-3-aryl-propionic alkyl ester.Type: ApplicationFiled: July 20, 2005Publication date: October 9, 2008Inventors: Thijs Kuilman, Horst Straatman
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Patent number: 7381841Abstract: Pentafluorosulfany0lphenyl-substituted benzoylguanidines, process for their preparation, theie use as medicament or diagnostic aed, and medicament comprising them Pentafluorosulfany0lphenyl-substituted benzoylguanidines of the formulae I and II in which R1, R1?, R2, R2?, R3, R3?, R4 and X have the meanings indicated in the claims, are suitable as antiarrhythmic medicaments with a cardioprotective component for the prophylaxis of infarction and treatment of infarction and for the treatment of angina pectoris. They also inhibit preventively the pathophysiological processes associated with the development of ischemia-induced damage, especially in the triggering of ischemia-induced cardiac arrhythmias.Type: GrantFiled: August 16, 2004Date of Patent: June 3, 2008Assignee: Sanofi-Aventis Deutschland GmbHInventor: Heinz-Werner Kleemann
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Patent number: 7358396Abstract: A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described.Type: GrantFiled: January 9, 2006Date of Patent: April 15, 2008Assignee: BASF AktiengesellschaftInventors: Klaus Ditrich, Wolfgang Siegel
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Patent number: 7288619Abstract: A composition comprises a condensation product of an amine-reactive fluorinated polyether and a polyamine. The compositions may be in dispersed in water.Type: GrantFiled: May 7, 2004Date of Patent: October 30, 2007Assignee: 3M Innovative Properties CompanyInventors: Zai-Ming Qiu, Naiyong Jing
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Patent number: 7262325Abstract: The present invention provides a fast, high yield method for preparing salicylamide intermediates. The method comprises reacting a C4 or higher alkyl ester of salicylic acid or derivative thereof with at least one amine selected from the group consisting of monoalkylamines, dialkylamines, ammonia, and any combination of any of the foregoing in alcohol to yield the salicylamide. The C4 or higher alkyl ester of salicylic acid or a derivative thereof is preferably prepared by reacting salicylic acid or a derivative thereof with a C4 or higher alcohol in presence of at least one of sulfuric acid, a sulfonic acid, and a mineral acid. This process for preparing salicylamide intermediates from salicylic acid or derivative thereof generally has a cycle time of about 2 days, and yields about 95% of a 99% pure material. In comparison, when a C3 or lower alkyl ester is used in lieu of the C4 or higher alkyl ester, the process generally has a cycle time of 7–9 days and yields about 60% of a 95% pure material.Type: GrantFiled: June 4, 2001Date of Patent: August 28, 2007Assignee: Emisphere Technologies, Inc.Inventors: William E. Bay, JoAnne P. Corvino
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Patent number: 7244864Abstract: The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wherein R1 represents a straight or branched (C1-C4)-alkyl group, with at least the stoichiometric amount of an amine of formula H2NR.Type: GrantFiled: November 28, 2001Date of Patent: July 17, 2007Assignee: Bracco Imaging S.p.A.Inventors: Pier Lucio Anelli, Marino Brocchetta, Giovanna Lux, Enrico Cappelletti
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Patent number: 7227037Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.Type: GrantFiled: February 5, 2003Date of Patent: June 5, 2007Assignee: WyethInventors: Scott Mason Duncan, Augustine Tobi Osuma, Sylvain Daigneault, Michel Bernatchez
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Patent number: 7205436Abstract: An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in making fabric care products and personal care products. The scope of this methodology has been demonstrated by converting water soluble organic sunscreen quaternary halides to their corresponding tosylates of Formula VI.Type: GrantFiled: May 13, 2005Date of Patent: April 17, 2007Assignee: Galaxy Surfactants LimitedInventors: Nirmal Madhukar Koshti, Shubhangi Dattaram Naik, Bharat Bhikaji Parab, Tanaji Shamrao Jadhav, Subhash Shivling Nashte
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Patent number: 7109371Abstract: A process for the preparation of prostaglandin compounds having the formula (I): wherein A is selected from the group consisting of C1–C6 alkyl groups; C7–C16 aralkyl groups wherein an aryl portion thereof is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; and (CH2)nOR? wherein n is an integer from 1 to 3 and R? represents a C6–C10 aryl group which is unsubstituted or substituted with one to three substituents selected from the group consisting of C1–C6 alkyl groups, halo and CF3; B is selected from OR? and NHR? wherein R? is C1–C6 alkyl groups; and represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.Type: GrantFiled: January 5, 2004Date of Patent: September 19, 2006Assignee: Johnson Matthey Public Limited CompanyInventors: Derek Wyndham Clissold, Stuart Wilbert Craig, Rajendrakumar Reddy Gadikota, Min He, Jurjus Fayez Jurayj, Shahrokh Kazerani, Erwin Rannala, Pradeep Kumar Sharma
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Patent number: 7087783Abstract: A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.Type: GrantFiled: October 4, 2004Date of Patent: August 8, 2006Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Emura, Tsuyoshi Haneishi
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Patent number: 7045139Abstract: An efficient, simple, high yielding, eco-friendly process for the manufacture of tosylates quaternary ammonium salts of cinnamidoalkylamines and/or benzamidoalkylamines (Formula I) has been described. These compounds are substantive UV-absorbers. They are useful in making fabric care products and personal care products. The scope of this methodology has been demonstrated by converting water soluble organic sunscreen quaternary halides to their corresponding tosylates of Formula VI.Type: GrantFiled: October 8, 2003Date of Patent: May 16, 2006Assignee: Galaxy Surfactants LimitedInventors: Nirmal Madhukar Koshti, Shubhangi Dattaram Naik, Bharat Bhikaji Parab, Tanaji Shamrao Jadhav, Subhash Shivling Nashte
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Patent number: 6965048Abstract: The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X, W, m and n are as defined hereinabove. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasite infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.Type: GrantFiled: July 1, 2004Date of Patent: November 15, 2005Assignee: Hoffmann-La Roche Inc.Inventors: Jean Ackermann, Johannes Aebi, Henrietta Dehmlow, Olivier Morand, Narendra Panday
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Patent number: 6908934Abstract: Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia ?and (b) Formula Ib are novel LXR agonists and are useful in the treatment of dyslipidemic conditions particularly depressed levels of HDL cholesterol.Type: GrantFiled: May 30, 2002Date of Patent: June 21, 2005Assignee: Merck & Co., Inc.Inventors: Alan D. Adams, Aileen Bouffard, James F. Dropinski, Clare E. Gutteridge, A. Brian Jones, Weiguo Lui, John George Ondeyka, Ali Shiafee, Sheo Bux Singh
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Patent number: 6900354Abstract: The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula wherein A is selected from R1, R3, R4, R5, R6, R7, R21, R22, R23, R24, and n are as defined herein or pharmaceutically acceptable salts thereof. The invention also relates to processes for preparation of such compounds, compositions containing them, and the use of such derivatives as MAO-B inhibitors. The invention further relates to methods for treating or preventing Alzheimer's disease and senile dementia by administering compounds of the invention.Type: GrantFiled: July 3, 2003Date of Patent: May 31, 2005Assignee: Hoffman-La Roche Inc.Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
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Publication number: 20040260123Abstract: This invention relates to a &bgr;-hydroxyalkylamide having the general Formula I: 1Type: ApplicationFiled: June 12, 2004Publication date: December 23, 2004Inventors: Andreas Kaplan, Rene Gisler
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Publication number: 20040220273Abstract: Benzamide compounds of Formula VII are prepared by reacting a benzoate compound of Formula V with an amine to obtain a benzamide compound of Formula VI, and then treating the benzamide VI with an amine deprotecting agent to obtain the benzamide VII; wherein R1 and R2 are each independently H, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, aryl, or substituted aryl; R3 is alkyl, -alkylaryl, or aryl; and P* is an amino protective group.Type: ApplicationFiled: March 10, 2004Publication date: November 4, 2004Inventors: Jaemoon Lee, Yong-Li Zhong
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Publication number: 20040186318Abstract: The invention relates to a novel process for preparing (2E)-2-(hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamides.Type: ApplicationFiled: January 27, 2004Publication date: September 23, 2004Inventors: Holger Weintritt, Reinhard Lantzsch, Thorsten Muh
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Publication number: 20040152919Abstract: Compounds of the general Formula: 1Type: ApplicationFiled: January 22, 2004Publication date: August 5, 2004Inventors: Uta Glufke, Paul Hanselmann
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Patent number: 6730705Abstract: The invention relates to new alkoximinoacetic acid amides, a process for their preparation and their use as agents for combating pests.Type: GrantFiled: June 30, 2000Date of Patent: May 4, 2004Assignee: Bayer AktiengesellschaftInventors: Thomas Seitz, Gerd Hänssler, Klaus Stenzel
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Patent number: 6670507Abstract: Compounds of formula I wherein R1 is for example 3-methoxyprop-3-yloxy, R2 is for example methoxy, R3 and R4 are in each case for example isopropyl, and R5 is H2NC(O)—[C(CH3)2]—CH2—, are obtainable by reaction of compounds of formula IV with a metal organic derivative of 1-(3-R1-4-R2-phen-1-yl)-2-R3-3-halogen propanes to form a compound of formula VI, followed by removal of the pseudoephedrine protecting group and the OH group, reaction of the resulting lactone with an amine R5—NH2 and removal of protecting group Z.Type: GrantFiled: January 15, 2003Date of Patent: December 30, 2003Assignee: Speedel Pharma AGInventors: Daniel Bellus, Alessandro Dondoni
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Patent number: 6660886Abstract: A magnetic recording medium including a lubricant topcoat having increased bonding to the medium surface comprises an amphiphilic lubricant molecule having a hydrophilic central portion including a plurality of polar functional groups bound to the medium surface and a pair hydrophobic fluoroalkyl ether or perfluoroalkylether end portions at respective ends of the hydrophilic central portion and extending away from the medium surface.Type: GrantFiled: February 1, 2002Date of Patent: December 9, 2003Assignee: Seagate Technology LLCInventors: Youmin Liu, Vidya Gubbi, Chung Shih
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Patent number: 6660872Abstract: The present invention relates to novel processes for preparing methoxyimino-acetamides.Type: GrantFiled: November 21, 2001Date of Patent: December 9, 2003Assignee: Bayer AktiengesellschaftInventors: Herbert Gayer, Bernd Gallenkamp, Peter Gerdes, Ulrich Heinemann, Walter Hübsch, Bernd-Wieland Krüger, Fritz Maurer, Holger Weintritt
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Publication number: 20030216593Abstract: The present invention provides a fast, high yield method for preparing salicylamide intermediates. The method comprises reacting a C4 or higher alkyl ester of salicylic acid or derivative thereof with at least one amine selected from the group consisting of monoalkylamines, dialkylamines, ammonia, and any combination of any of the foregoing in alcohol to yield the sali-cylamide. The C4 or higher alkyl ester of salicylic acid or a derivative thereof is preferably prepared by reacting salicylic acid or a derivative thereof with a C4 or higher alcohol in presence of at least one of sulfuric acid, a sulfonic acid, and a mineral acid. This process for preparing salicylamide intermediates from salicylic acid or derivative thereof generally has a cycle time of about 2 days, and yields about 95% of a 99% pure material. In comparison, when a C3 or lower alkyl ester is used in lieu of the C4 or higher alkyl ester, the process generally has a cycle time of 7-9 days and yields about 60% of a 95% pure material.Type: ApplicationFiled: December 2, 2002Publication date: November 20, 2003Inventors: William E. Bay, JoAnne P. Corvino
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Publication number: 20030181765Abstract: Compounds of formula (XII), are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is reacted with an Rio amine to form a carboxamide, the halogen is replaced with azide, if necessary after the introduction of a hydroxy protecting group, the resulting azide is converted to a lactone, the lactone is amidated and then the azide converted to the amine group, in order to obtain compounds of formula (I) or a salt thereof.Type: ApplicationFiled: January 24, 2003Publication date: September 25, 2003Inventors: Stefan Stutz, Peter Herold
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Patent number: 6613340Abstract: Substantive UV absorbing organic-soluble quaternary salts of cinnamidoalkylamine are described. Hair, skin and fabric care compositions containing the compounds of formula I. wherein R1 is a substituent, selected from H, halo, —OH, —NH2, —NO2, —OCH3, —N(CH3)2, alkyl groups containing from 1 to 6 carbon atoms, alkoxy groups containing from 1 to 6 carbon atoms, alkylamino or N,N-dialkylamino groups containing from 1 to 6 carbon atoms; R2 is selected from hydrogen, alkyl group containing from 1 to 12 carbon atoms; R3 and R4 are independently selected from benzyl, alkyl group containing from 1 to 12 carbon atoms; n is an integer from 1 to 6; R5 is selected from an alkyl group containing from 8 to 22 carbon atoms; alkenyl groups containing from 8 to 22 carbon atoms; R7 is selected from bromo, chloro, nitro, methyl and ethyl groups.Type: GrantFiled: July 31, 2001Date of Patent: September 2, 2003Assignee: Galaxy Surfactants Ltd.Inventors: Nirmal Madhukar Koshti, Arun Harchandra Jawale, Bharat Bhikaji Parab, Shubhangi Dattaram Naik, Manasi Dattatraya Moghe, Tanaji Shamrao Jadhav, Subhash Shivling Nashte
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Patent number: 6576792Abstract: The invention relates to a 2-halo-1-cycloalkenecarboxamides represented by Formula I: wherein n is 1 or 2; R is hydrogen or an alkyl group; and X is a halogen.Type: GrantFiled: May 4, 2001Date of Patent: June 10, 2003Assignee: Eastman Kodak CompanyInventor: Chang-Kyu Kim
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Patent number: 6555709Abstract: Aromatic amides, their preparation process and their use as pesticides.Type: GrantFiled: October 7, 1999Date of Patent: April 29, 2003Assignee: Hoechst Schering AgrEvo S.A.Inventors: Agnés Brouillard, Jacques Demassey, Philippe Dutheil, John Weston
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Patent number: 6552217Abstract: Disclosed is a 4-step process for the preparation of alkyl esters of 1-methylcyclopropanecarboxylic acid which comprises the steps of (1) converting &ggr;-butyrolactone to &agr;-methyl-&ggr;-butyrolactone; (2) converting the &agr;-methyl-&ggr;-butyrolactone from step (1) to an alkyl 4-halo-2-methylbutyrate; (3) producing a xylene solution of the alkyl 4-halo-2-methylbutyrate; and (4) contacting the xylene solution of an alkyl 4-halo-2-methylbutyrate from step (3) with an alkali metal alkoxide under conditions of temperature and pressure which causes vaporization of (i) an alkanol as it is formed and (ii) an alkyl 1-methylcyclopropanecarboxylate as it is formed from the alkyl 4-halo-2-methylbutyrate. Also disclosed are processes whereby the alkyl 1-methylcyclopropanecarboxylate, prepared as described above, is converted to 1-methylcyclopropylamine.Type: GrantFiled: July 2, 2001Date of Patent: April 22, 2003Assignee: Eastman Chemical CompanyInventors: John Clark Hubbs, David Carl Attride, Neil Warren Boaz, James Charles Ciula, John Thorton Maddox, Thomas Nabih, William Dell Nottingham, David Chris Spencer
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Patent number: 6506904Abstract: A method of preparing N,N-disubstituted 3,3′-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropi-onamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and N-substituted-3-mercaptopropionamide reacts with an aqueous solution of hydrogen peroxide. In addition, a method of preparing substituted 3-isothiazolone is provided.Type: GrantFiled: May 21, 2002Date of Patent: January 14, 2003Assignee: SK Chemicals Co., Ltd.Inventors: Seung-Hwan Kim, Jeong-Ho Park, Jin-Man Kim, Soon-Jong Hahn, Ki-Seong Choi, Myung-Ho Cho
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Patent number: 6498274Abstract: The invention concerns the use of amide derivatives of formula (I) wherein: R1 and R2 are substituents such as hydroxy, C1-6alkoxy, mercapto, C1-6alkylthio, amino, C1-6alkylamino and di-(C1-6alkyl)amino; m and p are independently 0-3R3 is C1-4alkyl; q is 0-4; and R4 is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokinesType: GrantFiled: March 7, 2000Date of Patent: December 24, 2002Assignee: Zeneca LimitedInventors: Dearg S Brown, George R Brown, Philip Cohen
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Patent number: 6479701Abstract: A method of preparing N,N-disubstituted-3,3′-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropionamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide of formula (3) and N-substituted-3-mercaptopropionamide reacts with an aqueous solution of hydrogen peroxide. In addition, a method of preparing substituted 3-isothiazolone is provided.Type: GrantFiled: September 28, 2001Date of Patent: November 12, 2002Assignee: SK Chemicals Co., Ltd.Inventors: Seung-Hwan Kim, Jeong-Ho Park, Jin-Man Kim, Soon-Jong Hahn, Ki-Seung Choi, Myung-Ho Cho
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Patent number: 6479710Abstract: A solid acid-base catalyst contains vanadium pentoxide hydrate. Moreover, it is preferable that the vanadium pentoxide hydrate in the solid acid-base catalyst has a composition which is represented by the following general equation (1): V2O5.nH2O (1) (n: 0.1-3). Creation of the vanadium pentoxide hydrate was confirmed by measuring X-ray diffraction spectrum shown in FIG. 1. In accordance with the above arrangement, the solid acid-base catalyst can sufficiently display catalytic activity under mild conditions, and it can be suitably applied to various reactions, such as the syntheses of olefins or ethers through dehydration reactions of alcohols, the syntheses of aldehydes or ketones through dehydrogenation reactions of alcohols, hydrations and isomerization reactions of olefins, alkylations, esterifications, amidations, acetalizations, aminations, hydrogen shift reactions, aldol condensation reactions and polymerization reactions.Type: GrantFiled: March 15, 1999Date of Patent: November 12, 2002Assignee: Nippon Shokubai Co., Ltd.Inventors: Nobuji Kishimoto, Etsushige Matsunami
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Patent number: 6469209Abstract: The present invention relates to novel acrylate-type N-methyl E-2-(2-methylphenyl)oxymethyl)-6-methylphenyl-glyoxylamide O-methyl oxime represented by formula (1), its preparation method and its use as fungicides. The compound of the present invention has not only stronger fungicidal effect on plant pathogens at low concentrations but also broader fungicidal spectrum than the conventional fungicides. Especially, because the compound has excellent systemic and curative effect as well as no toxicity, it can be used as an efficacious agricultural fungicide. In addition, the compound of the present invention can be useful as environmental-friendly fungicide capable of causing less environmental pollution fungicide due to its strong fungicidal effect at low concentrations.Type: GrantFiled: December 14, 2001Date of Patent: October 22, 2002Assignee: Dongbu Hannong Chemical Co., Ltd.Inventors: Hong Lim, Bong Jin Chung, Jong Sang Chung, In Young Choi, Dae Jong Park, Chang Il Hwang
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Patent number: 6469195Abstract: 2-Phenoxyphenylacetic acid derivatives of the formula I where the substituents and the index have the following meanings: A is where R1 is halogen, C1-C4-alkyl, C1-C4-alkoxy, CF3, C1-C4-haloalkoxy, formyl, C(═O)NRaRb or C(Ra)═NORb; Ra is hydrogen or C1-C4-alkyl; Rb is C1-C4-alkyl; n is 1, 2, 3 or 4, where the groups R1 may be different if n is not 1; R2 is halogen, CH3 or CF3; m is 0 or 1; and X is OCH3 or NHCH3; processes and intermediates for preparing the compounds I and the use of the compounds I for controlling harmful fungi are described.Type: GrantFiled: April 25, 2001Date of Patent: October 22, 2002Assignee: BASF AktiengesellschaftInventors: Wassilios Grammenos, Hubert Sauter, Andreas Gypser, Oliver Cullmann, Markus Gewehr, Bernd Müller, Arne Ptock, Norbert Götz, Roland Götz, Thorsten Volk, Eberhard Ammermann, Thomas Grote, Gisela Lorenz, Siegfried Strathmann