Phosphorus Attached Indirectly To Amino Nitrogen By Nonionic Bonding Patents (Class 564/15)
-
Patent number: 10961264Abstract: Provided herein is a process for isolating at least one (thio)phosphoric acid derivative, which has a boiling point of at least 70° C., from a product mixture including the at least one (thio)phosphoric acid derivative, at least one salt selected from ammonium salts and alkali metal chlorides, at least one polar solvent selected from the group consisting of ester solvents and ether solvents, and optionally at least one HCl scavenger; wherein the process is based on first dissolving the (thio)phosphoric acid derivative to be able to remove the at least one salt, and then causing solids formation of the (thio)phosphoric acid derivative.Type: GrantFiled: December 1, 2016Date of Patent: March 30, 2021Assignee: BASF SEInventors: Tobias Lang, Zoltan Baan, Philip Muelheims, Anton Flajs, Hartmut Denecke
-
Patent number: 9738668Abstract: Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided.Type: GrantFiled: May 24, 2016Date of Patent: August 22, 2017Assignee: University of KansasInventors: ShiDu Yan, Koteswara Rao Valasani
-
Publication number: 20150147361Abstract: The invention relates to the use of sphingosine based compounds, in particular phytosphingosine compounds, in the protection of hydroxyapatite containing materials such as teeth and bone. Such compounds are especially useful in the treatment and prevention of dental caries, dental erosion, dentine hypersensitivity and tartar (dental calculus) formation. Methods and devices are also provided for preventing biofilm formation using sphingosine based compounds. Compositions comprising sphingosine based compounds are also provided.Type: ApplicationFiled: April 26, 2013Publication date: May 28, 2015Applicant: Stichting VU-VUmcInventors: Floris Jacob Bikker, Engelmundus Cornelis Ignatius Veerman, Marianne Valentijn-Benz, Willem Van'T Hof
-
Publication number: 20150137083Abstract: Conjugated aromatic derivatives having an electron donating group and an electron accepting group at each end are provided. The conjugated aromatic derivatives of the present invention may be provided with blue light-emitting property and may be applied as a host material, a dopant material, an electron transporting material or a hole transporting material. An OLED device using the conjugated aromatic derivatives is also herein disclosed.Type: ApplicationFiled: April 16, 2014Publication date: May 21, 2015Applicant: National Tsing Hua UniversityInventors: Chien-Hong CHENG, Chih-Chun LIN
-
Publication number: 20150133688Abstract: New compounds which meet general formula (I): where: m=0, 1 or 2; R1 and R2=a C6 to C12, straight-chain or branched, hydrocarbon group; R3=H, a C1 to C12, straight-chain or branched, hydrocarbon group, optionally comprising one or more heteroatoms; a C3 to C8 monocyclic hydrocarbon group, optionally comprising one or more heteroatoms, or a monocyclic (hetero)aryl group; or else R2 and R3 together form a —(CH2)n— group where n=1 to 4; R4=a C2 to C8, straight-chain or branched, hydrocarbon group, or a monocyclic aromatic group; R5=H, or a C1 to C12, straight-chain or branched, hydrocarbon group.Type: ApplicationFiled: May 6, 2013Publication date: May 14, 2015Applicant: AREVA MinesInventors: Guilhem Arrachart, Nicolas Aychet, Gilles Bernier, Fabien Burdet, Antoine Leydier, Manuel Miguirditchian, Stephane Pellet-Rostaing, Gabriel Plancque, Raphael Turgis, Elisabeth Zekri
-
Publication number: 20150105296Abstract: Using NMR/MS based metabonomics and targeted lipidomics approaches the inventors have explored the metabolic phenotypes of aging and longevity in a cohort compromising centenarians, elderly and young adults. The inventors have identified biomarkers for a reduced risk of developing ageing related chronic inflammatory disorders and propose a method of diagnosing a lifestyle that allows delaying and/or avoiding ageing related chronic inflammatory disorders using hydroxy-sphingomyelin SM-OH-22:1 as biomarker.Type: ApplicationFiled: September 19, 2014Publication date: April 16, 2015Inventors: Sebastiano Collino, Ivan Montoliu Roura, Francois-Pierre Martin, Philippe Alexandre Guy, Serge Andre Dominique Rezzi
-
Publication number: 20150099165Abstract: The invention relates to an electrolyte for a lithium-based energy storage device comprising at least one lithium salt, a solvent and at least one compound of general formula (1), and to their use in lithium-based energy storage devices.Type: ApplicationFiled: October 31, 2012Publication date: April 9, 2015Inventors: Christian Dippel, Alexandra Lex-Balducci, Martin Winter, Miriam Kunze, René Schmitz, Romek Ansgar Müller, Stefano Passerini, Nataliya Kalinovich, Gerd-Volker Röschenthaler, Tobias Böttcher
-
Patent number: 8981126Abstract: Phosphenium compounds with the general formula I: in which R1, R2, R3 and R4 are identical or different and represent a linear or branched C1-C6-alkyl radical, which can optionally be substituted, or R1 and R2 and/or R3 and R4 are bonded to one another with the formation of a ring, R5 and R6 stand for a saturated or unsaturated and linear or branched alkyl group, alkenyl group or aryl group, which can have suitable substituents, even heteroatoms as substituents, or a heteroatom-comprising hydrocarbon group, which can have suitable substituents, and the R5 and R6 radicals can form a ring which can be 4- to 20-membered, saturated or unsaturated and alicyclic or heteroalicyclic and can exhibit suitable substituents, X? represents an anion, a process for the preparation thereof, and also the use of these compounds in metal complexes which can be used as catalysts in organic synthesis, are claimed.Type: GrantFiled: February 23, 2012Date of Patent: March 17, 2015Assignee: Studiengesellshaft Kohle mbHInventors: Manuel Alcarazo, Hans Bruns, Jekaterina Petuskova
-
Publication number: 20150057253Abstract: The present invention relates to alkyl derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.Type: ApplicationFiled: August 20, 2014Publication date: February 26, 2015Inventors: Wenkui K. Fang, Ken Chow, Evelyn G. Corpuz
-
Publication number: 20150045328Abstract: The present invention relates to aryl oxy derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.Type: ApplicationFiled: August 6, 2014Publication date: February 12, 2015Inventors: Wenkui K. Fang, Ken Chow, Evelyn G. Corpuz
-
Publication number: 20150025026Abstract: Campylobacter are the commonest reported bacterial causes of gastroenteritis in the UK and industrialized worlds. This invention relates to a method of preventing or reducing the colonisation of the gastrointestinal tract of an animal with Campylobacter. Accordingly, the present invention provides a method for disinfection of an animal comprising administering to said animal at least one compound that binds to MOMP or FlaA of Campylobacter in an effective amount to reduce the number of Campylobacter present in the gastrointestinal tract of said animal. The present invention also provides a method of preventing or reducing transmission of Campylobacter from one animal to another.Type: ApplicationFiled: February 15, 2013Publication date: January 22, 2015Inventors: Jafar Mahdavi, Dlawer Ala'Aldeen
-
Publication number: 20150005258Abstract: The invention discloses creatine derivatives that are represented by Formula (I), Formula (II), and Formula (III); wherein Z is a functional group; Y is a mitochondrial targeting agent, a cationic ammonium group, or a polypeptide containing at least one positively charged amino acid residue; each R1 is independently hydrogen, alkyl, or a phosphate group; R2 a linker; R3 is a spacer group; R4 is hydrogen, alkyl, aryl, or heterocyclic; or R4 and R1, or R4 and R3, together with the nitrogen atoms to which they are attached form a heterocyclic ring, and W is hydrogen or alkyl.Type: ApplicationFiled: September 18, 2012Publication date: January 1, 2015Applicant: Genci CorporationInventors: Shaharyar M. Khan, Robert Gadwood, Arthur Glenn Romero
-
Publication number: 20140319064Abstract: A preparation method of ethylenediamine core, octamethylenephosphonic acid terminated, PAMAM dendrimer and application thereof is provided, wherein terminal amino groups of ethylenediamine core, 0 generation, PAMAM dendrimer is modified by methylene phosphonic acid. The ethylenediamine core, octamethylenephosphonic acid terminated, PAMAM dendrimer has an excellent performance to inhibit scales of CaCO3, CaSO4 and Ca3(PO4)2, a very high calcium tolerance, and excellent dispersing performance. The ethylenediamine core, octamethylenephosphonic acid terminated, PAMAM dendrimer is used as an antiscalant in industrial water treatment, and is suitable for the industrial water treatment of boiler, cooling, desalination, and oil production, etc., especially for the industrial water treatment under high calcium concentration.Type: ApplicationFiled: July 16, 2013Publication date: October 30, 2014Inventors: Fengting Li, Bingru Zhang, Hongtao Wang, Yinan Wu
-
Publication number: 20140312311Abstract: An optoelectronic materials for OLED is represented by formula (I): wherein R1 is selected from a group consisting of formulas (II)-(VI): wherein R2 and R3 are identical and selected from a group consisting of formula (VII) and formula (VIII): The optoelectronic materials possesses superior luminescent performance and thermal stability and is suitable to be a new type of ambipolar materials for OLED elements.Type: ApplicationFiled: July 11, 2013Publication date: October 23, 2014Inventors: Chien-Tien CHEN, Wei-Shan CHAO, Hao-Wei LIU, Wei-Sheng SU
-
Publication number: 20140309422Abstract: The present invention relates to the compound of dialkyl(2-alkoxy-6-aminophenyl)phosphine and the preparation method thereof and the application in the palladium catalyzed coupling reactions of aryl chloride and ketone. The dialkyl(2-alkoxy-6-aminophenyl)phosphine of the present invention could coordinate with the palladium catalyst to highly selectively activate the inert carbon-chlorine bond, and to catalyze direct arylation reaction in the ?-position of ketones to produce corresponding coupling compounds. The preparation method of the present invention is a simple one-step method which produces the air-stable dialkyl(2-alkoxy-6-aminophenyl)phosphine. Compared with the synthetic routes of ligands to be used in the activation of carbon-chlorine bonds in the prior arts, the preparation method of the present invention has the advantages of short route and easy operation.Type: ApplicationFiled: July 3, 2012Publication date: October 16, 2014Applicant: ZHEJIANG UNIVERSITYInventors: Shengming Ma, Bo Lv, Chunling Fu
-
Patent number: 8859509Abstract: The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.Type: GrantFiled: May 13, 2009Date of Patent: October 14, 2014Assignee: Yale UniversityInventors: David Spiegel, Ryan Murelli, Andrew Zhang
-
Patent number: 8846645Abstract: The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.Type: GrantFiled: December 13, 2011Date of Patent: September 30, 2014Assignees: Rheinische Friedrich-Wilhelms Universität Bonn, Universität KonstanzInventors: Günter Mayer, Christina Elsbeth Luense, Valentin Wittmann, Magnus S. Schmidt
-
Patent number: 8846922Abstract: The present invention relates to functionalized fluoroalkylfluorophosphate salts, in particular as ionic liquids, to the preparation thereof and to the use thereof.Type: GrantFiled: August 30, 2011Date of Patent: September 30, 2014Assignee: Merck Patent GmbHInventors: Berthold Theo Hoge, Anne Julia Bader, Nikolai Mykola Ignatyev, Michael Schulte, Wolfgang Hierse, Waldemar Wiebe, Helge Willner
-
Publication number: 20140287640Abstract: Disclosure of functionalized ionic liquids. Use of disclosed ionic liquids as solvent for carbon dioxide. Use of disclosed ionic liquids as flame retardant. Use of disclosed ionic liquids for coating fabric to obtain flame retardant fabric.Type: ApplicationFiled: March 14, 2014Publication date: September 25, 2014Applicant: Materials Modification IncInventors: Humcha Krishnamurthy Hariprakasha, Krishnaswamy Kasthuri Rangan, Tirumalai Srinivas Sudarshan
-
Publication number: 20140249105Abstract: Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them.Type: ApplicationFiled: July 25, 2011Publication date: September 4, 2014Applicant: DiverchimInventors: Jean-Louis Brayer, Natacha Frison, Benoit Folleas
-
Publication number: 20140235592Abstract: The present invention relates to substituted 6-methoxy-4-amino-N-phenyl-2-naphtamides derivatives, processes for preparing them, pharmaceutical compositions to containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.Type: ApplicationFiled: February 19, 2014Publication date: August 21, 2014Applicant: Allergan, Inc.Inventors: Janet A. Takeuchi, Ling Li, Wha Bin Im
-
Publication number: 20140199601Abstract: The present invention aims to provide an additive for a non-aqueous electrolyte solution with excellent storage stability capable of forming a stable SEI on the surface of an electrode to improve cell performance such as a cycle performance, a discharge/charge capacity, and internal resistance, when the additive is used for electrical storage devices such as non-aqueous electrolyte solution secondary cells and electric double layer capacitors. The present invention also aims to provide a non-aqueous electrolyte solution containing the additive for a non-aqueous electrolyte solution and to provide an electrical storage device using the non-aqueous electrolyte solution.Type: ApplicationFiled: July 6, 2012Publication date: July 17, 2014Applicant: SUMITOMO SEIKA CHEMICALS CO., LTD.Inventors: Tomohiro Onozuka, Shohei Fujimoto, Koji Fujita
-
Publication number: 20140194638Abstract: The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R1, R2, R3, R4, R5, R6, R7, R8 and R9 having a value as defined in claim 1. Starting from the substituted 7-trifluoromesyloxy-7?-diarylphosphino-1,1?-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.Type: ApplicationFiled: July 27, 2012Publication date: July 10, 2014Applicant: ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD.Inventors: Qilin Zhou, Shoufei Zhu, Yanbo Yu, Kun Li, Lixin Wang
-
Publication number: 20140148415Abstract: S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the standard daily dosage.Type: ApplicationFiled: January 31, 2014Publication date: May 29, 2014Applicant: NOVARTIS AGInventors: Robert SCHMOUDER, Thomas DUMORTIER, Olivier DAVID, Michael LOOBY
-
Patent number: 8692022Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with bidentate ligands, having one amino or imino coordinating group and one phosphino coordinating group, in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.Type: GrantFiled: July 20, 2010Date of Patent: April 8, 2014Assignee: Firmenich SAInventors: Lionel Saudan, Philippe Dupau, Jean-Jacques Riedhauser, Patrick Wyss
-
Patent number: 8691718Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).Type: GrantFiled: September 20, 2006Date of Patent: April 8, 2014Assignee: Takeda Pharmaceutical Company LimitedInventors: Mitsuhisa Yamano, Mitsutaka Goto, Shinji Kawaguchi, Masatoshi Yamada, Jun-ichi Kawakami
-
Publication number: 20140093880Abstract: A composition, a kit, and a method of isolating a vesicle from a sample using a compound comprising zwitterion moieties, which may be used to analyze vesicles, and proteins, glycoprotein, lipids, or nucleic acids thereof.Type: ApplicationFiled: April 4, 2013Publication date: April 3, 2014Applicant: Samsung Electronics Co., Ltd.Inventors: Ga-hee KIM, Chang-eun YOO, Ye-ryoung YONG, Myo-yong LEE
-
Patent number: 8686154Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: GrantFiled: June 10, 2009Date of Patent: April 1, 2014Assignee: Emisphere Technologies, Inc.Inventors: Donald J. Sarubbi, Eugene N. Barantsevitch
-
Patent number: 8685936Abstract: The invention relates to prodrugs of hydroxyl-substituted adamantane compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.Type: GrantFiled: March 12, 2010Date of Patent: April 1, 2014Assignee: Apogee Biotechnology CorporationInventors: Charles D. Smith, Yan Zhuang, Lynn W. Maines
-
Publication number: 20140088303Abstract: Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtained by reacting a carbonyl compound and an organozinc compound by using a ligand (L) shown below.Type: ApplicationFiled: November 27, 2013Publication date: March 27, 2014Applicants: Sekisui Medical Co., Ltd., National University Corporation Nagoya UniversityInventors: Kazuaki ISHIHARA, Manabu HATANO, Takashi MIYAMOTO
-
Publication number: 20140066409Abstract: The present invention relates to compounds according to general formula (I), pharmaceutical compositions comprising compounds according to general formula (I) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.Type: ApplicationFiled: December 13, 2011Publication date: March 6, 2014Applicants: UNIVERSITÄT KONSTANZ, RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT BONNInventors: Günter Mayer, Christina Elsbeth Luense, Valentin Wittmann, Magnus S. Schmidt
-
Publication number: 20140057877Abstract: This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and PPAR partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan.Type: ApplicationFiled: October 18, 2011Publication date: February 27, 2014Inventors: Michael A. Murphy, Mitchell R. Malachowski
-
Patent number: 8658825Abstract: The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii) aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands of various structures. In particular, the methods in i) involve reacting a protected tertiary amine of formula (I) with a metal phosphide of the formula Y—PR8R9 to afford an aminophosphine of formula (II), which can then be optionally further reacted with a phosphine of the formula (III) to afford the phosphine-aminophosphine of formula (IV).Type: GrantFiled: June 9, 2008Date of Patent: February 25, 2014Assignee: Kanata Chemical Technologies Inc.Inventors: Kamaluddin Abdur-Rashid, Rongwei Guo, Xuanhua Chen, Wenli Jia
-
Publication number: 20140051870Abstract: Phosphenium compounds with the general formula I: in which R1, R2, R3 and R4 are identical or different and represent a linear or branched C1-C6-alkyl radical, which can optionally be substituted, or R1 and R2 and/or R3 and R4 are bonded to one another with the formation of a ring, R5 and R6 stand for a saturated or unsaturated and linear or branched alkyl group, alkenyl group or aryl group, which can have suitable substituents, even heteroatoms as substituents, or a heteroatom-comprising hydrocarbon group, which can have suitable substituents, and the R5 and R6 radicals can form a ring which can be 4- to 20-membered, saturated or unsaturated and alicyclic or heteroalicyclic and can exhibit suitable substituents, X? represents an anion, a process for the preparation thereof, and also the use of these compounds in metal complexes which can be used as catalysts in organic synthesis, are claimed.Type: ApplicationFiled: February 23, 2012Publication date: February 20, 2014Inventors: Manuel Alcarazo, Hans Bruns, Jekaterina Petuskova
-
Publication number: 20140001056Abstract: The invention relates to a method of inhibiting the insertion of one or more membrane proteins into a lipid bilayer. The invention also relates to a method of inserting a pre-determined number of membrane proteins into a lipid bilayer and lipid bilayers having a pre-determined number of membrane proteins inserted therein. The lipid bilayers of the invention are useful as sensor arrays, particularly for sequencing nucleic acids.Type: ApplicationFiled: January 11, 2012Publication date: January 2, 2014Applicant: ISIS INNOVATION LIMITEDInventors: John Hagan Pryce Bayley, Pinky Raychaudhuri
-
Patent number: 8609142Abstract: The present disclosure generally relates to methods of making nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol.Type: GrantFiled: December 13, 2012Date of Patent: December 17, 2013Assignee: BIND Therapeutics, Inc.Inventors: Greg Troiano, Michael Figa, Abhimanyu Sabnis
-
Patent number: 8609721Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.Type: GrantFiled: February 11, 2008Date of Patent: December 17, 2013Assignee: Georgetown UniversityInventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
-
Publication number: 20130253185Abstract: The present invention provides novel compounds and ligands that are useful in transition metal catalyzed cross-coupling reactions. For example, the compounds and ligands of the present invention are useful in palladium or gold catalyzed cross-coupling reactions.Type: ApplicationFiled: November 17, 2011Publication date: September 26, 2013Applicant: Dalhousie UniversityInventors: Rylan J. Lundgren, Mark Stradiotto
-
Patent number: 8536362Abstract: The present invention provides ?-hydroxy-?-aminophosphonates, ?-amino-?-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these ?-hydroxy-?-aminophosphonates, ?-amino-?-aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treatment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.Type: GrantFiled: March 22, 2012Date of Patent: September 17, 2013Assignee: Nucitec S.A. de C.V.Inventors: Ricardo Abraham De La Cruz Cordero, Miguel Ångel Duarte Vázquez, Jorge Luis Rosado Loria
-
Patent number: 8518913Abstract: The present invention relates to novel phosphorous derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.Type: GrantFiled: December 9, 2011Date of Patent: August 27, 2013Assignee: Allergan, Inc.Inventors: Haiqing Yuan, Richard I. Beard, Xiaoxia Liu, John E. Donello, Veena Viswanath, Michael E. Garst
-
Publication number: 20130216553Abstract: A method for detecting an inflammatory or an autoimmune condition, comprising analyzing bacterial lipids, such as phosphorylated dihydroceramides (PDHC), in a sample; and, comparing results of the analysis of the bacterial lipids in the sample with information on occurrence of the bacterial lipids in a comparable sample, wherein the comparison is indicative of the inflammatory or the autoimmune condition. An example of the autoimmune condition is multiple sclerosis. According to one embodiment, an increased ratio of phosphoglycerol dihydroceramide (PG DHC) to phosphoethanolamine dihydroceramide (PE DHC) in a blood sample indicates a presence of MS in the source patient. The use of PDHCs as biomarkers for detection of MS is described. Antibodies specific to PG DHC or PE DHC are also provided, along with their uses. Also provided are compositions comprising bacteria-originated lipids useful for modulation of immune responses or TLR pathways in humans, animals, and human or animal cells or tissues.Type: ApplicationFiled: October 31, 2011Publication date: August 22, 2013Applicant: University of ConnecticutInventors: Robert B. Clark, Frank C. Nichols
-
Publication number: 20130217916Abstract: The present invention describes tripodal catechol derivatives with an adamantyl basic framework for the functionalisation of surfaces, and methods for their production and use. A fourth remaining position of the adamantane skeleton is suitable to be optionally functionalised by so-called click reactions, for example with biomolecules, polyethylene glycol or active agents.Type: ApplicationFiled: September 7, 2011Publication date: August 22, 2013Applicant: JÜSTUS-LIEBIG-UNIVERSITÄT GIESSENInventors: Wolfgang Maison, Elisa Franzmann, Faiza Khalil
-
Publication number: 20130193382Abstract: The present invention relates to compounds of the formula (I) and to the use thereof in electronic devices. The invention furthermore relates to electronic devices, preferably organic electroluminescent devices (OLEDs), comprising one or more com-pounds of the formula (I). The invention again furthermore relates to the preparation of compounds of the formula (I) and to formulations comprising one or more compounds of the formula (I).Type: ApplicationFiled: September 6, 2011Publication date: August 1, 2013Applicant: MERCK PATENT GmbHInventors: Arne Buesing, Thomas Eberle, Irina Martynova, Teresa Mujica-Fernaud
-
Publication number: 20130197228Abstract: The present invention relates to functionalised fluoroalkylfluorophosphate salts, in particular as ionic liquids, to the preparation thereof and to the use thereof.Type: ApplicationFiled: August 30, 2011Publication date: August 1, 2013Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Berthold Theo Hoge, Anne Julia Bader, Nikolai Mykola Ignatyev, Michael Schulte, Wolfgang Hierse, Waldemar Wiebe, Helge Willner
-
Publication number: 20130158261Abstract: The present invention provides HIV protease inhibitors of formulas I, IA, IB, Ib or II, or pharmaceutically acceptable salts thereof, wherein R2 may be, for example, 2-pyridyl-CH2—, 3-pyridyl-CH2—, 4-pyridyl-CH2—, a sulfonyl group as described in the formulas herein including benzenesulfonyl or thiophenesulfonyl groups, R2a—CO)—, R2a being selected from the group consisting of piperonyl, 2-pyranzinyl (unsubstituted or substituted with H, or an alkyl of 1 to 4 carbon atoms) or a picolylamine group as described herein, wherein R3 may be, for example, a phenyl group or diphenylmethyl group as described herein, and wherein Cx may be, for example, COOH, CONR5R6, CH2OH or CH2OR7.Type: ApplicationFiled: February 15, 2013Publication date: June 20, 2013Applicant: TaiMed Biologics, Inc.Inventor: TaiMed Biologics, Inc.
-
Patent number: 8410247Abstract: Water soluble reagents and methods for the formation of an amide bond between a phosphinothioester and an azide in an aqueous medium. The phosphinothioester is generated using a water-soluble phosphinothiol reagent. This reaction allows formation of an amide bond between a wide variety of chemical species including amino acids, peptides or protein fragments in an aqueous solution. Of particular interest, this reaction allows for the formation of an amide bond in a physiological setting. In a specific embodiment, this invention provides reagents and methods for peptide ligation in an aqueous medium. The reaction eliminates the need for a cysteine residue and is traceless leaving no residual atoms in the ligated peptide product.Type: GrantFiled: August 24, 2009Date of Patent: April 2, 2013Assignee: Wisconsin Alumni Research FoundationInventors: Ronald T. Raines, Annie Tam, Matthew B. Soellner
-
Patent number: 8378100Abstract: The present invention provides ?-hydroxy phosphonate compounds that are autotaxin inhibitors.Type: GrantFiled: January 9, 2009Date of Patent: February 19, 2013Assignee: University of Virginia Patent FoundationInventors: Kevin R. Lynch, Timothy L. Macdonald
-
Patent number: 8361993Abstract: The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: -n and m denote, independently of one another, an integer ranging from 1 to 4, —X denotes an oxygen atom or an N—R3 group, —R1 and R3 denote, independently of one another, a linear or branched C1 to C6 alkyl group, and —R2 denotes a residue of a molecule of therapeutic or diagnostic interest, or pharmaceutically acceptable salts of said derivatives, and also the method for the preparation thereof and the therapeutic or diagnostic use thereof.Type: GrantFiled: January 5, 2009Date of Patent: January 29, 2013Assignees: Universite de Nantes, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS)Inventors: Maxim Egorov, Yannick Fortun, Dominique Heymann, Jacques Lebreton, Monique Mathe, Marc Padrines, Francoise Redini
-
Patent number: 8343450Abstract: Methods and compositions to extract radionuclides such as various actinides and lanthanides from organic and/or aqueous solutions by utilizing extractant functionalized carbon nanotubes are disclosed. More particularly, phosphorous-containing (such as phosphine oxides, phosphoric acids or phosphates) organic extractants and other predesigned extractants (such as crown ethers, calncrown derivatives, malonamide and diglycolamide derivatives, polyethylene glycol derivatives, cobalt dicarbollide derivatives, and N-donating heterocyclic ligands) can be covalently and/or non-covalently employed on the surfaces and/or ends (tips) of carbon nanotubes for the purpose of removal radionuclides such as various actinides and lanthanides from organic and/or aqueous solutions. Extractant functionalized carbon nanotubes can be used for extracting radioactive nuclides from nuclear waste or spent nuclear fuel, which are produced and/or reprocessed from the nuclear power generation or other nuclear application.Type: GrantFiled: October 8, 2008Date of Patent: January 1, 2013Assignee: Chemnano Materials, Ltd.Inventor: Pingshan Wang
-
Patent number: 8329676Abstract: The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type, which alter lymphocyte trafficking. The compounds of the invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.Type: GrantFiled: July 12, 2010Date of Patent: December 11, 2012Assignee: University of Virginia Patent FoundationInventors: Kevin R. Lynch, Timothy L. Macdonald