Phosphorus Attached Indirectly To Amino Nitrogen By Nonionic Bonding Patents (Class 564/15)
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Publication number: 20100240615Abstract: The invention relates to novel NO donors which are targeted to the mitochondria. The NO donor compounds of the invention allow NO to be selectively provided to the mitochondria.Type: ApplicationFiled: March 26, 2010Publication date: September 23, 2010Applicants: University of Orago, Medical Research CouncilInventors: Robin Andrew James Smith, Michael Patrick Murphy
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Patent number: 7799824Abstract: Quaternary salt compounds of Formula (I) or pharmaceutically acceptable forms thereof, which are CCR2 antagonists and are useful in preventing, treating or ameliorating CCR2 mediated inflammatory syndromes, disorders or diseases in a subject in need thereof.Type: GrantFiled: June 22, 2005Date of Patent: September 21, 2010Assignee: OraPharma, Inc.Inventors: Bharat Lagu, Michael Wachter
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Publication number: 20100228052Abstract: The present invention relates to an improved process for the synthesis of Ibandronate sodium of formula (I). The present invention also provides novel processes for the synthesis of 3-[N-(methylpentyl)amino]propionic acid (III).Type: ApplicationFiled: June 22, 2007Publication date: September 9, 2010Applicant: CIPLA LTD.Inventors: Dharamaraj Ramchandra Rao, Rajendra Narayanrao Kankan, Maruti Ganpati Ghagare
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Patent number: 7790923Abstract: The invention is directed to a process for the production of certain phosphorous, namely urea, thio-urea and sulphonamide phosphorous compounds. The present invention provides a process for the production of phosphorous compounds which process allows an easy and effective separation of the reaction products from impurities by applying a solid alkaline ion-exchange resin.Type: GrantFiled: January 26, 2007Date of Patent: September 7, 2010Assignee: BASF Nederland B.V. and University of AmsterdamInventors: Albertus Jacobus Sandee, Alida Maria Van Der Burg, Joost Nicolaas Hendrik Reek
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Patent number: 7772340Abstract: A subject-matter of the invention is alkoxyamines resulting from ?-phosphorated nitroxides corresponding to the formula: in which R represents an alkyl radical having a number of carbon atoms ranging from 1 to 3, R1 represents a hydrogen atom or a residue: in which R3 represents an alkyl radical having a number of carbon atoms ranging from 1 to 20, and R2 represents a hydrogen atom, an alkyl radical having a number of carbon atoms ranging from 1 to 8, a phenyl radical, an alkali metal, such as Li, Na or K, H4N+, Bu4N+ or Bu3HN+, exhibiting a kinetic dissociation constant kd, measured at 120° C. by EPR, of greater than 0.05 s?1. These compounds can be used as initiators for the (co)polymerizations of at least one monomer which can be polymerized by the radical route.Type: GrantFiled: July 23, 2003Date of Patent: August 10, 2010Assignee: Arkema FranceInventors: Jean-Luc Couturier, Olivier Guerret, Denis Bertin, Didier Gigmes, Sylvain Marque, Paul Tordo, Florence Chauvin, Pierre-Emmanuel Dufils
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Patent number: 7767846Abstract: A novel class of compounds that includes HPTS-Cys-MA, and methods of making them are disclosed herein. The class of compounds including HPTS-Cys-MA are useful as fluorescent dyes for analyte detection.Type: GrantFiled: August 22, 2008Date of Patent: August 3, 2010Assignee: Glumetrics, Inc.Inventor: Jeff T Suri
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Publication number: 20100186961Abstract: Novel aminoacid alkylphosphonic acid compounds are disclosed. These compounds can be used in multiple applications, in particular in a scale inhibitor functionality in aqueous systems, including in marine oil recovery.Type: ApplicationFiled: May 25, 2007Publication date: July 29, 2010Inventors: Patrick Notte, Albert Devaux
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Patent number: 7754703Abstract: The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds with hydrolysis-resistant phosphate surrogates such as phosphonates, alpha-substituted phosphonates, and phosphothionates.Type: GrantFiled: February 14, 2006Date of Patent: July 13, 2010Assignee: University of Virginia Patent FoundationInventors: Kevin R. Lynch, Timothy L. Macdonald
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Publication number: 20100172967Abstract: Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like.Type: ApplicationFiled: February 19, 2010Publication date: July 8, 2010Applicants: KYOWA HAKKO KIRIN CO., LTD., TECHNO NETWORK SHIKOKU CO., LTD.Inventors: Hisao Nemoto, Masahiro Yamauchi, Hiroko Kusano, Yasuki Kato, Motoo Yamasaki, Toshiyuki Suzawa
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Publication number: 20100160258Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.Type: ApplicationFiled: October 30, 2009Publication date: June 24, 2010Applicant: BIOGEN IDEC MA INC.Inventors: Richard D. Caldwell, Kevin M. Guckian, Gnanasambandam Kumaravel, Wen-Cherng Lee, Edward Yin-Shiang Lin, Xiaogao Liu, Bin Ma, Daniel M. Scott, Zhan Shi, Jermaine Thomas, Arthur G. Taveras, Guo Zhu Zheng
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Publication number: 20100160615Abstract: A bisphosphonoaminc compound represented by the following formula (I): wherein R1, R2, R3, R4 and R5 are independently an alkyl group having 1 to 6 carbon atoms, and n is an integer of 1 to 6, is extremely useful as an intermediate for preparing a technetium nitride complex for radiodiagnostic imaging.Type: ApplicationFiled: January 20, 2006Publication date: June 24, 2010Applicant: NIHON MED-PHYSICS CO., LTD.Inventors: Francesco Tisato, Fiorenzo Refosco, Cristina Bolzati, Stefania Agostini, Marina Porchia, Mario Cavazza-Ceccato, Shinji Tokunaga
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Publication number: 20100152465Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.Type: ApplicationFiled: February 26, 2010Publication date: June 17, 2010Applicant: University of South AlabamaInventor: James Hillard Davis, JR.
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Patent number: 7723542Abstract: The invention relates to a process for the preparation of diphosphonic acids by reaction of a carboxylic acid with a mixture of phosphorous acid and phosphorus oxychloride in defined molar ratios and in the absence of solvents. The invention further relates to ibandronic acid monosodium salt in the amorphous form.Type: GrantFiled: December 22, 2004Date of Patent: May 25, 2010Assignee: Trifarma S.p.A.Inventors: Simona Grassi, Anna Volante
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Publication number: 20100125149Abstract: There are provided crystalline forms of Ibandronate sodium and process for preparing thereof.Type: ApplicationFiled: April 18, 2008Publication date: May 20, 2010Applicants: Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc.Inventors: Surya Narayana Devarakonda, Ram Thaimattam, Balaji Raghupati, Minakshi Asnani, Satish Kumar Vasamsetti, Srinivasulu Rangineni, Vamsi Krishna Muppidi
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Publication number: 20100125132Abstract: A method for making diazo-compounds, diazonium salts thereof and other protected forms of these compounds. Diaz-compounds are prepared by reaction of a tertiary phosphine reagent carrying a reactive carbonyl group with an azide. The reaction can also generate an acyl triazene which can be converted thermally or by addition of base to form the diazo-compound or the acyl triazene can be isolated. The method is particularly useful for conversion of azides carrying one or more electron withdrawing groups to diazo-compounds. The method can be carried out in aqueous medium under mild conditions and is particularly useful for conversion of azido sugars to diazo-compound and diazonium salts thereof under physiological conditions. Tertiary phosphine reagents, particularly those that are water-soluble, and precursors for preparation of the reagents are provided.Type: ApplicationFiled: November 17, 2009Publication date: May 20, 2010Inventors: Ronald Thaddeus Raines, Eddie Leonard Myers
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Publication number: 20100125144Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with tetradentate ligands having at least one amino or imino coordinating group and at least one phosphino coordinating group in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.Type: ApplicationFiled: January 27, 2010Publication date: May 20, 2010Inventors: LIONEL SAUDAN, PHILIPPE DUPAU, JEAN-JACQUES RIEDHAUSER, PATRICK WYSS
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Patent number: 7714089Abstract: Rubbery polymers can be formed having the general formula: R1R2N—(CH2)n—X—CH2—CHR3R4 wherein R1 and R2 are independently selected from a group consisting of alkyls, cycloalkyls, alkenyls, cycloalkenyls, aryls, phenyls, heterocycles, acyls, and silanes, or R1 in combination with R2 forms a heterocyclic ring; n is an integer from 1 to 20; X is selected from a group consisting of sulfur, a phosphorus moiety, and a silicon moiety; R3 and R4 are one of hydrogen, alkyls, alkenyls, and at least one of which includes reactive unsaturation such as an alkenyl group. Moreover, this invention discloses a process of making functionalized rubbery polymers from the functionalized monomers.Type: GrantFiled: December 13, 2007Date of Patent: May 11, 2010Assignee: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wen-Liang Hsu, Leh-Yeh Hsu, legal representative, Shingo Futamura, Joe Zhou, Chad Aaron Jasiunas
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Publication number: 20100111930Abstract: A method to determine the utility of small molecules as functional replacements (mimetics) for protein receptor ligands is described. The method uses cellular biological assays on a systematic array of compounds, comprising known protein receptor ligands and other biologically active molecules to determine if a proposed small molecule is a functional equivalent of a receptor ligand, having therapeutic utility as a pharmaceutically relevant and useful agent either alone or in combination with other molecules.Type: ApplicationFiled: November 9, 2007Publication date: May 6, 2010Applicant: ALPHAPTOSE GMBHInventors: Vladimir Khazak, Lutz Weber
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Publication number: 20100113397Abstract: Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5-cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.Type: ApplicationFiled: August 29, 2008Publication date: May 6, 2010Inventors: Chi-Huey Wong, Jim-Min Fang, Jiun-Jie Shie, Yih-Shyun Edmond Cheng, Jia-Tsrong Jan
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Publication number: 20100092386Abstract: The present invention relates to a novel delivery system for delivering therapeutic agents into living cells, and more particularly, to novel chemical moieties that are designed capable of targeting and/or penetrating cells or other targets of interest and further capable of binding therapeutic agents to be delivered to these cells, and to delivery systems containing same.Type: ApplicationFiled: October 22, 2009Publication date: April 15, 2010Inventor: David SEGEV
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Publication number: 20100094001Abstract: The present invention provides a process or the like which is employed for producing chloromethyl phosphate derivatives that are useful for producing water-soluble prodrugs, and which are excellent from the points of view of workability, operativity and energy saving. According to the present invention, there is provided a process for producing a composition containing a compound represented by the following formula (I) and a tertiary amine, (wherein R1 and R2 are identical or different from each other, and represent a C1-C6 alkyl group, a C2-C6 alkenyl group or a C6-C14 aryl C1-C6 alkyl group which may have a substituent, and R1 and R2 may together form a ring), the process comprising the step of adding the tertiary amine having a boiling point at 1 atmosphere of 150° C. or higher to the compound represented by formula (I).Type: ApplicationFiled: March 5, 2008Publication date: April 15, 2010Applicant: Eisai R&D Management Co., Ltd.Inventors: Keizo Sato, Shinya Abe, Kazuhiro Yoshizawa, Kazunori Wakasugi, Shigeto Negi, Mamoru Miyazawa
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Patent number: 7696184Abstract: The present invention relates to amino-propanol derivatives, process for their production, their uses in treating and/or preventing diseases or disorders mediated by lymphocyte interactions, and pharmaceutical compositions containing them. For example, Compounds of formula I wherein A, R1, R2, R3, R4 and R5 are as defined in the specification are described.Type: GrantFiled: June 11, 2004Date of Patent: April 13, 2010Assignee: Novartis AGInventors: Claus Ehrhardt, Klaus Hinterding
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Publication number: 20100087400Abstract: The present invention provides ?-hydroxy-?-aminophosphonates, ?-amino-?-aminophosphonates, and analogs thereof that inhibit carnitine acyltransferases. The invention also provides compositions comprising these ?-hydroxy-?-aminophosphonates, ?-amino-?-aminophosphonates, and analogs, and methods of the use of such compounds and compositions in the treatment, amelioration or prevention of pathological conditions, diseases or disorders that are linked with fatty acid metabolism, such as non-insulin dependent diabetes or obesity. The invention also provides processes for the preparation of such compounds and compositions.Type: ApplicationFiled: October 8, 2009Publication date: April 8, 2010Applicant: Nucitec S.A. de C.V.Inventors: Ricardo Abraham De La Cruz Cordero, Miguel Angel Duarte Vázquez, Jorge Luis Rosado Loria
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Publication number: 20100081634Abstract: The present invention relates to compounds of phosphonic acid-containing T3 mimetics and monoesters thereof, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndrome x and diabetes.Type: ApplicationFiled: May 26, 2006Publication date: April 1, 2010Applicant: METABASIS THERAPEUTICS, INC.Inventors: Mark D. Erion, Hongjian Jiang, Serge H. Boyer
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Publication number: 20100069618Abstract: The invention concerns a process for preparing a hybrid organic-inorganic material (HOIM) with phosphorus-containing bridges between the surface of an inorganic substrate containing an element M and one or more organic groups of the covalent M-O-P-R type, said process using, as a precursor for said organic group or groups, at least one organophosphorus acid halide with formula RxP(O)Xy in which x=1 or 2, y=3?x, X being a halogen and R designating at least one organic alkyl, aryl or aryl-alkyl group. Non-exhaustive applications for the hybrid organic-inorganic material obtained by the process of the invention are in the fields of anti-corrosion, lubrication, microelectronics, nanotechnologies, composite materials, heterogeneous catalysis, supported catalysis, depollution and biomedical applications.Type: ApplicationFiled: July 6, 2007Publication date: March 18, 2010Applicant: IFPInventors: Renaud Revel, Florence Brodard-Severac, Gilles Guerrero, Hubert Mutin, Alain Forestiere, Alexandra Chaumonnot
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Publication number: 20100048866Abstract: Water soluble reagents and methods for the formation of an amide bond between a phosphinothioester and an azide in an aqueous medium. The phosphinothioester is generated using a water-soluble phosphinothiol reagent. This reaction allows formation of an amide bond between a wide variety of chemical species including amino acids, peptides or protein fragments in an aqueous solution. Of particular interest, this reaction allows for the formation of an amide bond in a physiological setting. In a specific embodiment, this invention provides reagents and methods for peptide ligation in an aqueous medium. The reaction eliminates the need for a cysteine residue and is traceless leaving no residual atoms in the ligated peptide product.Type: ApplicationFiled: August 24, 2009Publication date: February 25, 2010Inventors: Ronald T. Raines, Annie Tam, Matthew B. Soellner
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Publication number: 20100036081Abstract: Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.Type: ApplicationFiled: August 31, 2007Publication date: February 11, 2010Applicants: TOKAI UNIVERSITY EDUCATIONAL SYSTEM, TOKYO MEDICAL AND DENTAL UNIVERSITYInventors: Yu Nagase, Naoya Shimoyamada, Yasuhiko Iwasaki, Kazuhiko Ishihara
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Publication number: 20100016258Abstract: The present invention provides ?-hydroxy phosphonate compounds that are autotaxin inhibitors.Type: ApplicationFiled: January 9, 2009Publication date: January 21, 2010Inventors: Kevin R. Lynch, Timothy L. Macdonald
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Publication number: 20100003616Abstract: A photosensitive monolayer is self-assembled on an oxide surface. The chemical compound of the photosensitive monolayer has three components. A first end group provides covalent bonds with the oxide surface for self assembly on the oxide surface. A photosensitive group that dissociates upon exposure to ultraviolet radiation is linked to the first end group. A second end group linked to the photosensitive group provides hydrophobicity. Upon exposure to the ultraviolet radiation, the dissociated photosensitive group is cleaved and forms a hydrophilic derivative in the exposed region, rendering the exposed region hydrophilic. Carbon nanotubes or nanocrystals applied in an aqueous dispersion are selectively attracted to the hydrophilic exposed region to from electrostatic bonding with the hydrophilic surface of the cleaved photosensitive group.Type: ApplicationFiled: August 8, 2009Publication date: January 7, 2010Inventors: Ali Afzali-Ardakani, Teresita O. Graham, James B. Hannon, George S. Tulevski
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Publication number: 20090324540Abstract: Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.Type: ApplicationFiled: June 10, 2009Publication date: December 31, 2009Applicant: Emisphere Technologies, Inc.Inventors: Donald J. Sarubbi, Eugene N. Barantsevitch
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Publication number: 20090325907Abstract: To provide an amino phosphate derivative having an excellent sphingosine-1-phosphate (S1P) receptor modulatory action. As a result of continued intensive research to create a highly safe compound which has an S1P receptor modulatory action, is has been discovered that an amino phosphate derivative represented by the following general formula (1), has a strong S1P receptor modulatory action.Type: ApplicationFiled: August 7, 2007Publication date: December 31, 2009Inventors: Yasushi Kohno, Kiyoshi Fujii, Tatsuhiro Saito
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Publication number: 20090312289Abstract: The present invention relates to a new crystalline polymorph of 3-(N-methyl-N-pentyl)amino-1-hydroxypropane-1,1-diphosphonic acid monosodium salt monohydrate (Ibandronate) with the following formulaType: ApplicationFiled: July 17, 2009Publication date: December 17, 2009Inventors: Uwe Eiermann, Bernd Junghans, Bernhard Knipp, Tim Settelkau
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Publication number: 20090306382Abstract: The instant invention relates to cationic alkoxyamines, which are useful as polymerization initiators/regulators in a controlled stable free radical polymerization process to produce intercalated and/or exfoliated nanoparticles from natural or synthetic clays, The invention also relates to improved nanocomposites produced by this process and to the use of these nanocomposite compositions as, for example, coatings, sealants, caulks, adhesives and as plastic additives.Type: ApplicationFiled: August 5, 2009Publication date: December 10, 2009Inventors: ANDREAS Mühlebach, Peter Nesvadba, Andreas Kramer
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Publication number: 20090274972Abstract: An electrostatic-image-developing toner includes a phosphonic acid based sequestering agent.Type: ApplicationFiled: December 15, 2008Publication date: November 5, 2009Applicant: FUJI XEROX CO., LTD.Inventors: Shuji SATO, Eisuke IWAZAKI, Atsushi SUGAWARA, Masanobu NINOMIYA, Hiroshi NAKAZAWA
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Publication number: 20090270635Abstract: The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein R4 is a hydrogen atom or a C1-6 alkyl group optionally having substituent(s), and R5 and R6 are each a C1-6 alkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).Type: ApplicationFiled: September 20, 2006Publication date: October 29, 2009Inventors: Mitsuhisa Yamano, Mitsutaka Goto, Shinji Kawaguchi, Masatoshi Yamada, Jun-ichi Kawakami
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Publication number: 20090253658Abstract: To provide a fat accumulation inhibitor and a food or drink for inhibiting fat accumulation, a visceral fat accumulation inhibitor and a food or drink for inhibiting visceral fat accumulation, or an agent for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood and a food or drink for accelerating increase and/or inhibiting decrease of an adiponectin concentration in blood. A fat accumulation inhibitor for a fat cell, which comprises a milk-derived phospholipid as an active ingredient, and a food or drink for inhibiting fat accumulation in a fat cell, which comprises a milk-derived phospholipid. A visceral fat accumulation inhibitor comprising a sphingosine-containing phospholipid or a derivative thereof as an active ingredient, and a food or drink for inhibiting visceral fat accumulation.Type: ApplicationFiled: April 6, 2007Publication date: October 8, 2009Inventors: Reo Tanaka, Tomoyuki Isogai, Yuko Haruta, Susumu Miura, Ken Kato, Toshimitsu Yoshioka, Hiroshi Kawakami, Satoshi Higurashi, Hiroaki Matsuyama
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Publication number: 20090221851Abstract: The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2) (in the formula (2), R1 represents an alkyl group having 1 to 4 carbon atom(s), R2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s); and * represents an asymmetric carbon atom), wherein a compound represented by the formula (1) (in the formula (1), R1 represents an alkyl group having 1 to 4 carbon atom(s), R2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s)) iType: ApplicationFiled: September 3, 2007Publication date: September 3, 2009Inventors: Nobuto Minowa, Nozomu Nakanishi, Masaaki Mitomi, Hideki Nara, Tohru Yokozawa
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Publication number: 20090203648Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: ApplicationFiled: April 14, 2009Publication date: August 13, 2009Applicants: Centre National de la Recherche Scientifique, Universite de Nantes, Institut National de la Sante et de la Recherche MedicaleInventors: Bruno Bujoli, Solen Josse, Jerome Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
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Publication number: 20090197838Abstract: The present invention relates to a formulation comprising a N-halogenated amino acid and a phase transfer agent. The present invention also describes a method for disinfecting and/or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid salt for a time sufficient to disinfect and/or clean the lens.Type: ApplicationFiled: April 30, 2008Publication date: August 6, 2009Applicant: ALCON RESEARCH, LTD.Inventors: L. Wayne Schneider, Wesley Wehsin Han, Masood A. Chowhan, David W. Stroman, W. Dennis Dean, Michael S. Gaines
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Patent number: 7560582Abstract: One aspect of the present invention relates to novel ligands for transition metals. A second aspect of the present invention relates to the use of catalysts comprising these ligands in transition metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The subject methods provide improvements in many features of the transition metal-catalyzed reactions, including the range of suitable substrates, reaction conditions, and efficiency.Type: GrantFiled: July 23, 2007Date of Patent: July 14, 2009Assignee: Massachusetts Institute Of TechnologyInventors: Stephen L. Buchwald, David W. Old, John P. Wolfe, Michael Palucki, Ken Kamikawa
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Publication number: 20090163740Abstract: The present invention provides a family of novel and stable ligands which chelate with a metal to form a complex. The ligand contains a t-butyl group or a ring, particularly a substituted aromatic group, linked to a nitrogen atom. The nitrogen atom further links to PR1R2, PR1R2R9, P(?O)R1R2, NR1R2, OR1, SR1, or AsR1R2 group with a saturated or unsaturated hydrocarbon such that the structure of the ligand can be stabilized.Type: ApplicationFiled: December 5, 2008Publication date: June 25, 2009Inventor: Lan-Chang LIANG
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Publication number: 20090156769Abstract: Rubbery polymers can be formed having the general formula: R1R2N—(CH2)n—X—CH2—CHR3R4 wherein R1 and R2 are independently selected from a group consisting of alkyls, cycloalkyls, alkenyls, cycloalkenyls, aryls, phenyls, heterocycles, acyls, and silanes, or R1 in combination with R2 forms a heterocyclic ring; n is an integer from 1 to 20; X is selected from a group consisting of sulfur, a phosphorus moiety, and a silicon moiety; R3 and R4 are one of hydrogen, alkyls, alkenyls, and at least one of which includes reactive unsaturation such as an alkenyl group. Moreover, this invention discloses a process of making functionalized rubbery polymers from the functionalized monomers.Type: ApplicationFiled: December 13, 2007Publication date: June 18, 2009Inventors: Adel Farhan Halasa, Wen-Liang Hsu, Leh-Yeh Hsu, Shingo Futamura, Joe Zhou, Chad Aaron Jasiunas
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Publication number: 20090156556Abstract: Compounds of formula I: wherein R1, R2, n and m are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.Type: ApplicationFiled: February 24, 2009Publication date: June 18, 2009Inventors: Rainer Albert, Eric Francotte, Frederic Zecri, Markus Zollinger
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Patent number: 7547631Abstract: Organometallic compounds containing a phosphoamidinate ligand are provided. Such compounds are particularly suitable for use as vapor deposition precursors. Also provided are methods of depositing thin films, such as by ALD and CVD, using such compounds.Type: GrantFiled: October 4, 2006Date of Patent: June 16, 2009Assignee: Rohm and Haas Electronic Materials LLCInventors: Deodatta Vinayak Shenai-Khatkhate, Qing Min Wang
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Publication number: 20090143620Abstract: The invention provides a transition metal complex of formula (3) below: wherein R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and each independently represents a hydrogen atom, a halogen atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); R5 represents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); X1 represents a hydrogen atom, a halogen atom or a substituted or unsubstituted alkyl group having 1 to 10 carbon atom(s); L represents a balancing counter ion or neutral ligand similar to X1 that is bonding or coordinating to metal M; and q represents an integer of 0 or 1, and G20 represents any one of G21 to G26 below: where A1 represents an element of Group 15 of the periodic table, wherein A1 in G23 represents an anion of an element of Group 15 of the periodic table, and A1 in G21 represents a nitrogen atom; R9, R14, R12, R13, R19, R20, R10, R11, R15, R16, R17, R18, R19, R20, R21 and R22 eaType: ApplicationFiled: December 4, 2008Publication date: June 4, 2009Inventors: Yuka Otomaru, Hidenori Hanaoka
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Publication number: 20090137383Abstract: Organic compounds containing heteroatoms and their use in preparing Ziegler-Natta (Ziegler-Natta) catalyst with single activation center. The Ziegler-Natta olefin polymerization catalyst is preparing by adding organic or inorganic solid carrier or compound of them which is pre-activated by heating or pre-treated chemically, organic compound containing heteroatoms and metallic compound into magnesium compound/tetrahydrofuran solution. The Ziegler-Natta olefin polymerization catalyst prepared in the present invention is fluidizable powder and can prepare ethene homopolymer and copolymer of controllable construction with high catalytic activity, during homo-polymerization and combined polymerization with alpha-olefin of C3˜C18 under action of catalyst promoter such as alkyl aluminum, alkyl aluminoxane, and so on.Type: ApplicationFiled: November 21, 2008Publication date: May 28, 2009Applicant: Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInventors: Yong TANG, Xiaohong Yang, Bo Liu, Xiuli Sun, Zhi Ma, Yuan Gao, Cong Wang
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Publication number: 20090131717Abstract: Disclosed are a composition for protecting skin and uses thereof. The composition comprises sphingomyelin as an active ingredient and protects the skin by inhibiting skin aging, treating a skin wound and improving a skin barrier.Type: ApplicationFiled: January 16, 2009Publication date: May 21, 2009Inventors: Changseo PARK, Sunki Kim, Jinwook Kim, Hyeongjoon Kang, Bokyung Han, Younggon Lee, Soyoung Chung, Wangkeun Choi, Sang June Nam
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Publication number: 20090118236Abstract: The present invention relates to compounds of phosphonic acid containing T3 mimetics, stereoisomers, pharmaceutically acceptable salts, co-crystals, and prodrugs thereof and pharmaceutically acceptable salts and co-crystals of the prodrugs, as well as their preparation and uses for preventing and/or treating metabolic diseases such as obesity, NASH, hypercholesterolemia and hyperlipidemia, as well as associated conditions such as atherosclerosis, coronary heart disease, impaired glucose tolerance, metabolic syndromex and diabetes.Type: ApplicationFiled: November 19, 2004Publication date: May 7, 2009Inventors: Mark D. Erion, Hongjian Jiang, Serge H. Boyer
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Publication number: 20090118239Abstract: Provided are amorphous and crystalline forms of ibandronate disodium, as well as processes for the preparation thereof.Type: ApplicationFiled: May 15, 2008Publication date: May 7, 2009Inventors: Sharon Avhar-Maydan, Claude Singer, Tamas Koltai
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Publication number: 20090099390Abstract: A crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about 4.1, 12.3 and 13.4±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 8.2, 11.3, 16.2 and 16.9 and 20.8±0.2 degrees two-theta, and by a powder X-ray diffraction pattern depicted in FIG. 1 is provided. Also provided is a crystalline ibandronic acid characterized by data selected from the group consisting of at least one of a powder x-ray diffraction pattern having peaks at about peaks at about 5.2, 11.7, and 18.7±0.2 degrees two-theta and at least two more peaks selected from the group consisting of: 5.8, 10.1, 12.0, 17.1, and 20.0±0.2 degrees two-theta and a powder X-ray diffraction pattern as depicted in FIG. 2. Methods of preparing the crystalline forms are also provided.Type: ApplicationFiled: September 24, 2008Publication date: April 16, 2009Inventors: Claude Singer, Sharon W. Avhar-Maydan, Tamas Koltai, Amir Gold