Sulfur Containing Patents (Class 564/154)
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Patent number: 4857572Abstract: Novel compositions are described which contain an elastomer or a tackifying resin and at least one compound of formula I ##STR1## The symbols R.sub.1 is alkyl or cycloalkyl, R.sub.2 is alkyl, hydroxyalkyl, phenyl or benzyl, and R.sub.3 is hydrogen or methyl with the proviso that, when R.sub.1 is other than methyl, R.sub.3 is methyl.Type: GrantFiled: February 10, 1988Date of Patent: August 15, 1989Assignee: Ciba-Geigy CorporationInventors: Hans-Rudolf Meier, Gerrit Knobloch
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Patent number: 4855286Abstract: The invention relates to compounds of the formula ##STR1## in which R.sup.1 is absent or denotes hydrogen, alkyl or acyl, A denotes an acyl radical or an amino acid residue, B denotes an amino acid residue, and R.sup.2, R.sup.3 and R.sup.4 are as defined in the specification, and to their salts, to a process for their preparation, to pharmaceutical products containing them, and to their use as medicaments, and intermediates for the preparation of these compounds.Type: GrantFiled: July 28, 1987Date of Patent: August 8, 1989Assignee: Hoechst AktiengesellschaftInventors: Adalbert Wagner, Heinz-Werner Kleemann, Dieter Ruppert, Bernward Scholkens
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Patent number: 4845286Abstract: Provided is an acetylene-terminated aromatic amide compound of the formula ##STR1## wherein X is --O-- or --S--, Z is --O--, --S--, --SO.sub.2 --, or --CO--, and R is --H or --C.tbd.CH in the ortho, meta or para position, wherein at least one R is --.tbd.CH.Type: GrantFiled: August 24, 1987Date of Patent: July 4, 1989Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Robert C. Evers, Tonson Abraham, Edward J. Soloski
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Patent number: 4840969Abstract: An N-substituted benzamide of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents halogenoalkyl with more than one carbon atom, or represents cycloalkyl which is substituted by halogen or halogenoalkyl andR.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are identical or different and represent hydrogen, halogen, nitro, alkyl, halogenoalkyl, halogenoalkoxy or halogenoalkylthio, or represent the radical--CONR.sup.1 R.sup.2.The N-substituted benzamides are active as insecticides and nematicides and can be prepared by reacting a benzoyl halide of the formula (II) ##STR2## in which R.sup.8, R.sup.9, R.sup.10, R.sup.11 and R.sup.12 are identical or different and represent hydrogen, halogen, nitro, alkyl, halogenoalkyl, halogenoalkoxy or halogenoalkylthio, or represent the radical --CO--Hal and Hal represents halogen,with an amine of the formula (III)HNR.sup.1 R.sup.2 (III)in whichR.sup.1 and R.sup.2 have the abovementioned meanings, or with corresponding hydrohalides.Type: GrantFiled: March 19, 1987Date of Patent: June 20, 1989Assignee: Bayer AktiengesellschaftInventors: Horst Tarnow, Bernhard Homeyer
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Patent number: 4839357Abstract: Peptides of the formula: ##STR1## which comprise novel elements replacing the Phe(8)-His(9) sequence in renin-inhibitory peptides based on substrate analogy, which inhibit the substrate-cleaving action of renin and have improved bioavailability; compositions containing these renin-inhibitory peptides, optionally with other antihypertensive agents; and methods of treating hypertension or congestive heart failure or of establishing renin as a causative factor in these problems which employ the novel peptides.Type: GrantFiled: October 2, 1987Date of Patent: June 13, 1989Assignee: Merck & Co., Inc.Inventors: Arthur A. Patchett, William J. Greenlee, William H. Parsons, Prasun K. Chakravarty
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Patent number: 4837352Abstract: An intermediate compound having the structural formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n - wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.3 and R.sup.4 together can be oxo; R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms; R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub. 1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n - wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.Type: GrantFiled: March 21, 1988Date of Patent: June 6, 1989Assignee: Stauffer Chemical CompanyInventor: Christopher G. Knudsen
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Patent number: 4827016Abstract: Dermal inflammations which are induced and propagated by leukotrienes are treated by topically applying to the inflamed dermis the following compound: ##STR1## wherein R.sup.3 is H or a thiol; n is 1 to 12; p is 0 to 12; X is a substituted carbonyl, such as an ester or a carboxylic acid; and Y is an aliphatic or branched hydrocarbon, aromatic ring, carbonyl or substituted amide.Type: GrantFiled: July 20, 1987Date of Patent: May 2, 1989Inventor: Lee R. Morgan
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Patent number: 4826876Abstract: This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.Type: GrantFiled: December 21, 1987Date of Patent: May 2, 1989Assignee: Smith Kline & French Laboratories LimitedInventors: David Ellis, John C. Emmett, Anthony H. Underwood, Paul D. Leeson
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Patent number: 4820719Abstract: This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.Type: GrantFiled: May 16, 1988Date of Patent: April 11, 1989Assignee: SmithKline Beckman CorporationInventors: John G. Gleason, Ralph F. Hall, Thomas Wen-Fu Ku, Carl D. Perchonock
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Patent number: 4816066Abstract: Compounds of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkyl, cyano, nitro, S(O).sub.n R wherein R is C.sub.1 -C.sub.4 alkyl and n is the integer 0, 1 or 2; and R.sup.2 through R.sup.8 are hydrogen or certain substituents, their salts, herbicidal compositions containing the compound or salts and the herbicidal use thereof.Type: GrantFiled: December 4, 1987Date of Patent: March 28, 1989Assignee: Stauffer Chemical CompanyInventors: William J. Michaely, Gary W. Kraatz
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Patent number: 4808628Abstract: An amide derivative of the formula (I): ##STR1## or a tautomeric form thereof, wherein R is a phenyl group substituted in the 4-position by a group of R.sup.1 XCH.sub.2--, where R.sup.1 is C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.1 -C.sub.4 alkynyl, C.sub.1 -C.sub.4 alkylcarbonyl, or H, and X is oxygen or sulphur; E is CN, or CSNH.sub.2, or CONH.sub.2 ; and Y is C.sub.1 -C.sub.4 alkoxy, C.sub.3 -C.sub.4 alkenyloxy, C.sub.3 -C.sub.4 alkynyloxy, 1-pyrazolyl or 2-furyl. Compositions and processes for using these derivatives to combat plant fungi are also disclosed.Type: GrantFiled: November 12, 1987Date of Patent: February 28, 1989Assignee: Imperial Chemical Industries PLCInventors: Margaret C. Shephard, Patrick J. Crowley
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Patent number: 4808572Abstract: Novel asymmetric thioethers of the formula ##STR1## in which the general symbols have the following meanings: a is an integer of from 1 to 7,R.sup.o represents hydrogen or C.sub.1-7 -alkanoyl,R.sup.1 represents C.sub.1-3 -alkyl which may be substituted at the terminal carbon atom by a free or acylated hydroxy group, by a halogen atom having an atomic number of at most 17, or by methoxy, or represents C.sub.1-3 -perfluoroalkyl,R.sup.2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms,A represents ethylene or alternatively, if R.sup.1 represents a halogenated radical and/or B represents phenylene or ethylene, a single bond or vinylene,B represents a single bond, ethynylene or phenylene,R.sup.3 represents hydroxy, C.sub.Type: GrantFiled: December 1, 1986Date of Patent: February 28, 1989Assignee: Ciba-Geigy CorporationInventors: Andreas Beck, Werner Breitenstein, Andreas von Sprecher, Robert W. Lang, Konrad Oertle
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Patent number: 4806146Abstract: Compounds of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, cyano, nitro, S(O).sub.n R wherein R is C.sub.1 -C.sub.4 alkyl and n is the integer 0, 1 or 2; and R.sup.2 through R.sup.8 are hydrogen or certain substituents, their salts, herbicidal compositions containing the compound or salts and the herbicidal use thereof.Type: GrantFiled: February 8, 1988Date of Patent: February 21, 1989Assignee: Stauffer Chemical CompanyInventor: Charles G. Carter
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Patent number: 4804781Abstract: A process for preparing thioether amide diol comprising reacting a bicyclic amide acetal with hydrogen sulfide at a temperature in the range of from 20.degree. to 200.degree. C. wherein a mole ratio of bicyclic amide acetal to hydrogen sulfide is in the range of from about 1:1 to about 2:1 is described.Type: GrantFiled: April 16, 1986Date of Patent: February 14, 1989Assignee: Ashland Oil, Inc.Inventor: Anil B. Goel
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Patent number: 4801721Abstract: Methods for the alkylation of substituted amines with trifluorate esters is disclosed.Type: GrantFiled: December 19, 1986Date of Patent: January 31, 1989Inventors: James W. Ryan, Alfred Chung
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Patent number: 4801609Abstract: Novel mercapto-acylamino acids useful in the treatment of hypertension and combinations of mercapto-acylamino acids and atrial natriuretic peptides useful for treating hypertension are disclosed.Type: GrantFiled: March 27, 1987Date of Patent: January 31, 1989Assignee: Schering CorporationInventors: Martin F. Haslanger, Bernard R. Neustadt, Elizabeth M. Smith
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Patent number: 4783213Abstract: Compounds of the formula ##STR1## wherein X is oxy, thio, sulfinyl or sulfonyl;R is halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; trifluoromethoxy; difluoromethoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl, trifluoromethyl or difluoromethyl;R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are C.sub.2 -C.sub.5 alkylene;R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl with the proviso that R.sup.1 and R.sup.3 are not both phenyl or substituted phenyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, or phenyl;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.Type: GrantFiled: August 20, 1987Date of Patent: November 8, 1988Assignee: Stauffer Chemical CompanyInventor: David L. Lee
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Patent number: 4781751Abstract: Compounds of the formula ##STR1## wherein R is halogen; C.sub.1 -C.sub.2 alkyl; C.sub.1 -C.sub.2 alkoxy; trifluoromethoxy; difluoromethoxy; nitro; cyano; C.sub.1 -C.sub.2 haloalkyl; R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; trifluoromethyl or difluoromethyl;R.sup.1 is hydrogen, C.sub.1 -C.sub.4 alkyl, halogen, phenyl or substituted phenyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are C.sub.2 -C.sub.5 alkylene;R.sup.3 is hydrogen, C.sub.1 -C.sub.4 alkyl, phenyl or substituted phenyl, with the proviso that R.sup.1 and R.sup.3 are not both phenyl or substituted phenyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.5 is hydrogen, halogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is halogen, cyano, nitro, trifluoromethyl, --C(O)--OR.sup.f wherein R.sup.f is C.sub.1 -C.sub.4 alkyl, or --C(O)NR.sub.2.sup.b wherein R.sup.b is hydrogen or C.sub.1 -C.sub.2 alkyl;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.Type: GrantFiled: October 2, 1987Date of Patent: November 1, 1988Assignee: Stauffer Chemical CompanyInventor: Hsiao-Ling M. Chin
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Patent number: 4775662Abstract: The compounds represented by the formula (I) ##STR1## wherein n is 1 or 2; m is 0, 1 or 2; p is 9, 10, 11, 12 or 13; X is hydrogen or hydroxyl; R is hydroxyl or amino; R.sub.1 is hydrogen, amino or ##STR2## and R.sub.2 is hydroxyl, amino, ##STR3## with the proviso that when m is 0, R.sub.1 is hydrogen or pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.Type: GrantFiled: October 29, 1987Date of Patent: October 4, 1988Assignee: SmithKline Beckman CorporationInventors: John G. Gleason, Thomas W. Ku
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Patent number: 4766242Abstract: Provided is a novel and effective process for the synthesis of aryl sulfides substituted with an alkanoylamino or (N-alkyl)alkanoylamino substituent. The process comprises reacting an appropriately substituted aromatic compound with a sulfur dihalide, preferably sulfur dichloride, in the presence of an alkali metal tetrafluoroborate catalyst and an ether comprising solvent.Type: GrantFiled: February 1, 1982Date of Patent: August 23, 1988Assignee: Hoechst Celanese CorporationInventors: Harry T. Hanson, John B. Sapp, Jr.
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Patent number: 4766201Abstract: The process for preparing hydroxy alkyl amide thio ethers by the reaction of a bicyclic amide acetal with a thiol is described.Type: GrantFiled: January 20, 1987Date of Patent: August 23, 1988Assignee: Ashland Oil Inc.Inventor: Anil B. Goel
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Patent number: 4762551Abstract: A compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.3 and R.sup.4 can be oxo; R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms; and R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.Type: GrantFiled: June 9, 1986Date of Patent: August 9, 1988Assignee: Stauffer Chemical CompanyInventor: Christopher G. Knudsen
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Patent number: 4757153Abstract: The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen, lower alkyl, hydroxy, lower alkoxy, --O(CH.sub.2).sub.n phenyl with the phenyl optionally substituted by halogen, --NO.sub.2, --CN, --NH.sub.2 or lower alkyl wherein n is 1 to 4; R.sup.2 and R.sup.3 represent lower alkyl, halogen, or lower alkoxy, or either one of R.sup.2 or R.sup.3 is hydrogen and the other is lower alkyl, lower alkoxy or halogen; R.sup.4, R.sup.5, R.sup.6, and R.sup.9 may be the same or different and represent hydrogen, lower alkyl, cycloalkyl having 3 to 8 carbons, unsaturated lower alkyl, or --(CH.sub.2).sub.m cycloalkyl with the cycloalkyl having 3 to 8 carbons and m is 1 to 4; R.sup.10 is hydrogen or --(CH.sub.2).sub.p phenyl or with the phenyl optionally substituted with --NH.sub.2, --OH, halogen, --NO.sub.2, or lower alkyl or --(CH.sub.2).sub.p thienyl wherein p is 1 to 4; one of R.sup.7 or R.Type: GrantFiled: July 14, 1986Date of Patent: July 12, 1988Assignee: G. D. Searle & Co.Inventors: Donald W. Hansen, Jr., Daniel R. Pilipauskas, Michael Clare
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Patent number: 4751240Abstract: A phenol derivative of the formulaNU--A--X--R.sup.1wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl-hydroxyindanyl, phenyl-hydroxybenzothienyl or mono-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R.sup.1 is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R.sup.1 is joined to R.sup.2, and wherein X is --CONR.sup.2 --, --CSNR.sup.2 --, --NR.sup.12 CO--, --NR.sup.12 CS--, --NR.sup.12 CONR.sup.2 --, ##STR1## --SO.sub.2 NR.sup.2 --or --CO--, or, when R.sup.1 is not hydrogen, is --NR.sup.12 COO--, --(PO)R.sup.2 13 , --S--, --SO--or --SO.sub.2 --, wherein R.sup.2 is hydrogen or alkyl, or R.sup.1 and R.sup.2 together form alkylene; wherein R.sup.12 is hydrogen or alkyl, and wherein R.sup.22 is hydrogen, cyano or nitro; or a salt thereof when appropriate.Type: GrantFiled: April 24, 1985Date of Patent: June 14, 1988Assignee: Imperial Chemical Industries PLCInventors: Jean Bowler, Graham C. Crawley, Philip N. Edwards, Alasdair T. Glen, Michael S. Large, Brian S. Tait
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Patent number: 4748274Abstract: The present invention relates to compounds which are 4-hydroxy-4-alkenylcyclohexanecarboxylic acid derivatives possessing leukotriene antagonist activity. The compounds are useful in the treatment of allergic diseases, particularly in the treatment of human asthma. They are prepared by the reaction of an appropriate oxaspiro compound with a mercaptoalkanoic acid derivative.Type: GrantFiled: November 7, 1986Date of Patent: May 31, 1988Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Robert J. Cregge, Nelsen L. Lentz
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Patent number: 4737300Abstract: The invention relates to material containing aldosemarcaptals of the formula I ##STR1## wherein n can be an integer from 2 to 6, and wherein R.sup.1 and R.sup.2 are identical or different, and in each case are C.sub.1 -C.sub.18 -alkyl, which is unsubstituted, substituted or interrupted by --O-- or --S--, or are --(CH.sub.2).sub.r --CO--N(C.sub.1 -C.sub.17 -alkyl).sub.2, r being 1 or 2, or are phenyl, benzyl or --(CH.sub.2).sub.r --CO--O--R.sup.3, in which r can be 1 or 2 and R.sup.3 is an alkali metal or C.sub.1 -C.sub.14 -alkyl; also wherein R.sup.1 and R.sup.2 are --CH.sub.2 --CH(OH)--R.sup.4, in which R.sup.4 is hydrogen, or C.sub.1 -C.sub.16 -alkyl, unsubstituted or substituted by --OH, or --CH.sub.2 --Y--(C.sub.1 -C.sub.15 -alkyl), in which Y is --O-- or --S--; or wherein R.sup.1 and R.sup.2 together form --(CH.sub.2).sub.Type: GrantFiled: May 10, 1985Date of Patent: April 12, 1988Assignee: Ciba-Geigy CorporationInventors: Hermann O. Wirth, Hans-Helmut Friedrich
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Patent number: 4736055Abstract: Oxime sulfonates of formula I ##STR1## wherein Y is a polymerizable unsaturated group or epoxide group or an --OH, --NHR.sup.5, --COOH, COOR.sup.6, --COCl, --CH.sub.2 Hal, --SO.sub.2 Cl or --NCO group, Z is an (x+y)-valent connecting member, R.sup.1 and R.sup.2 are monovalent organic radicals, m is 0 or 1, x is 1 or 2 and y is 1 or 2, can be converted into polymers which can be thermally or photochemically dissociated to form free sulfonic acid groups. Said polymers can therefore be used as photoresists which can be developed with aqueous alkalis.Type: GrantFiled: April 11, 1986Date of Patent: April 5, 1988Assignee: Ciba-Geigy CorporationInventors: Kurt Dietliker, Werner Rutsch, Godwin Berner, Max Hunziker, Christopher G. Demmer
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Patent number: 4736040Abstract: 1,2-Benzisothiazolones and their alkali metal salts are prepared by reacting 2,2'-dithiodibenzamides in the presence of oxygen or oxygen donors in an aqueous alkaline medium to which a water-soluble organic solvent may be added and, if desired, freeing the benzisothiazolones from the alkali metal salts with acid.Type: GrantFiled: January 2, 1986Date of Patent: April 5, 1988Assignee: BASF AktiengesellschaftInventors: Peter Tonne, Hagen Jaedicke
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Patent number: 4727105Abstract: There is disclosed a compound having the structureA--S--X--S--A' Iwherein A and A' are radicals independently selected from the group consisting of the following structures: ##STR1## wherein R.sub.1 and R.sub.2 are tertiary alkyl radicals having 4 to 8, preferably 4 to 6 carbon atoms, n is a whole number of 1 to 8, R.sub.3 and R.sub.4 are the same or different radicals selected from the group consisting of hydrogen and alkyl radicals having 1 to 18 carbon atoms, R.sub.5 is hydrogen or methyl and Z is --O-- or ##STR2## A' can also be hydrogen; and X is a divalent oligomeric segmer having the structure: ##STR3## wherein m ranges from an average of 4 to about 24. There is also disclosed a polymeric cmposition comprising a polymer susceptible to the degradative effects of oxidation having incorporated therein an antidegradant amount of a compound of Structure I.Type: GrantFiled: January 25, 1985Date of Patent: February 23, 1988Assignee: The Goodyear Tire & Rubber CompanyInventor: Roger J. Hopper
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Patent number: 4727188Abstract: o,o'-Dithiodibenzamides of the formula ##STR1## where R.sup.1 and R.sup.2 are each hydrogen, alkyl or phenyl, R.sup.3 is hydrogen, halogen, nitro, methyl or methoxy, and R.sup.4 has the same meanings as R.sup.3, are prepared by nitrosating an anthranilamide of the formula ##STR2## and reacting the product with sulfur dioxide in the presence of copper or a copper salt.Type: GrantFiled: March 28, 1985Date of Patent: February 23, 1988Assignee: BASF AktiengesellschaftInventor: Hagen Jaedicke
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Patent number: 4705805Abstract: Certain 2,2'-dithiobis-N-substituted or unsubstituted benzamides or derivatives thereof are useful as antithrombotic agents because of their ability to suppress aggregation of blood platelets.Type: GrantFiled: February 17, 1987Date of Patent: November 10, 1987Inventors: Koji Yamada, Tamotsu Hashimoto, Masao Naruse, Yo Murayama, Hideki Ninno
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Patent number: 4698364Abstract: Benzoic acid derivatives of the formula: ##STR1## wherein n is an integer of 0 to 2; R.sub.1 to R.sub.3 which may be the same or different each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or nitro group; R.sub.4 is a hydroxyl group or the group --NHZ (Z is hydrogen atom or a lower alkyl group), or an alkali metal salts thereof are useful as an infection control agent.These derivatives excepting compounds of the formula above wherein n is 0 or 1; any one of R.sub.1 to R.sub.3 is 5-chloro, 5-methoxy or 5-nitro and the remainder is a hydrogen atom; and R.sub.4 is a hydroxyl group; and compounds of the formula wherein n is 0 or 1; two of R.sub.1 to R.sub.3 are 3,5-dichloro or 3,5-dinitro and the remainder is a hydrogen atom; and R.sub.4 is a hydroxy group) are novel, and they were first prepared in this invention.Type: GrantFiled: October 18, 1985Date of Patent: October 6, 1987Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Mitsuru Tanemura, Isao Matsunaga, Masami Saitou
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Patent number: 4698416Abstract: The process for preparing novel polymers by the reaction of a bicyclic amide acetal with sulfur at a temperature in the range of from about 25.degree. C. to about 200.degree. C. is described.Type: GrantFiled: June 23, 1986Date of Patent: October 6, 1987Assignee: Ashland Oil, Inc.Inventors: Anil B. Goel, Harvey J. Richards
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Patent number: 4684482Abstract: Compounds are described of the general formula: ##STR1## wherein: R.sub.1 is acyl of the formula --C(.dbd.O)--R.sub.5 ; R.sub.2, R.sub.3, and R.sub.4 are each selected from the group consisting of hydrogen and acyl of the formula:--C(.dbd.O)--R.sub.5wherein R.sub.5 is selected from the group consisting of alkyls, substituted alkyls, alkenyls, substituted alkenyls, cycloalkyls, substituted cycloalkyls, arylalkylenes, substituted arylalkylenes, alkylenecycloalkyls, alkylene substituted cycloalkyls, alkynyls, substituted alkynyls, aryls and substituted aryls, wherein R.sub.2, R.sub.3 and R.sub.4 are selected such that at least one of R.sub.2, R.sub.3 and R.sub.4 is an acyl. When R.sub.2, R.sub.3 and R.sub.4 include one or more acyls that are not identical to the acyl of R.sub.1, these compounds of formula I are novel compounds. The invention also includes processes to produce the compounds of formula I. Compounds of formula I complex and/or chelate tissue tri-valent ions, especially iron (Fe.sup.Type: GrantFiled: January 26, 1984Date of Patent: August 4, 1987Assignee: Oral-D (L.P.)Inventor: Donald E. Green
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Patent number: 4681966Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents lower alkyl, phenyl, or phenyl lower alkyl; R.sub.2 represents lower alkyl; and R.sub.5 represents lower alkyl. These compounds are useful as intermediates in the preparation of collagenase inhibiting compounds which are useful in the treatment of arthritis and are of the formula ##STR2## wherein R.sub.1 represents lower alkyl, phenyl or phenyl lower alkyl; R.sub.2 and R.sub.4 represent lower alkyl; and R.sub.3 represents lower alkyl, benzyloxyalkyl, alkoxybenzyl or benzyloxybenzyl wherein the oxyalkyl or alkoxy moiety contain 1 to 6 carbon atoms; and a, b, and c represent chiral centers with optional R or S stereochemistry.Type: GrantFiled: April 2, 1986Date of Patent: July 21, 1987Assignee: G. D. Searle & Co.Inventors: David K. Donald, Michael M. Hann, John Saunders, Harry J. Wadsworth
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Patent number: 4675443Abstract: New epoxy resins are prepared by reacting a hydroxybenzamide or derivative thereof with an epihalohydrin followed by dehydrohalogenation. These epoxy resins have crystalline melting points, self-cure at elevated temperatures and cure rapidly in the presence of the usual epoxy resin curing agents. Also disclosed are hydrolyzed products of these epoxy resins and subsequent reactions with polyisocyanates.Type: GrantFiled: May 13, 1982Date of Patent: June 23, 1987Assignee: The Dow Chemical CompanyInventors: James L. Bertram, Edmund P. Woo
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Patent number: 4673765Abstract: New epoxy resins are prepared by reacting a hydroxybenzamide or derivative thereof with an epihalohydrin followed by dehydrohalogenation. These epoxy resins have crystalline melting points, self-cure at elevated temperatures and cure rapidly in the presence of the usual epoxy resin curing agents. Also disclosed are hydrolyzed products of these epoxy resins and subsequent reactions with polyisocyanates.Type: GrantFiled: May 13, 1982Date of Patent: June 16, 1987Assignee: The Dow Chemical CompanyInventors: James L. Bertram, Edmund P. Woo
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Patent number: 4673764Abstract: New epoxy resins are prepared by reacting a hydroxybenzamide or derivative thereof with an epihalohydrin followed by dehydrohalogenation. These epoxy resins have crystalline melting points, self-cure at elevated temperatures and cure rapidly in the presence of the usual epoxy resin curing agents. Also disclosed are hydrolyzed products of these epoxy resins and subsequent reactions with polyisocyanates.Type: GrantFiled: May 13, 1982Date of Patent: June 16, 1987Assignee: The Dow Chemical CompanyInventors: James L. Bertram, Edmund P. Woo
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Patent number: 4671901Abstract: Compounds are described of the general formula: ##STR1## wherein: R.sub.1 is acyl of the formula --C(.dbd.O)--R.sub.5 ; R.sub.2, R.sub.3, R.sub.4, R.sub.6, R.sub.7 and R.sub.8 are each selected from the group consisting of hydrogen and acyl of the formula:--C(.dbd.O)--R.sub.5wherein R.sub.5 is selected from the group consisting of alkyls, substituted alkyls, alkenyls, substituted alkenyls, cycloalkyls, substituted cycloalkyls, arylalkylenes, substituted arylalkylenes, alkylenecycloalkyls, alkylene substituted cycloalkyls, alkynyls, substituted alkynyls, aryls and substituted aryls, wherein R.sub.2, R.sub.3 and R.sub.4 are selected such that at least one of R.sub.2, R.sub.3 and R.sub.4 is an acyl. When R.sub.2, R.sub.3 and R.sub.4 include one or more acyls that are not identical to the acyl of R.sub.1, these compounds of formula I are novel compounds. The invention also includes processes to produce the compounds of formula I.Type: GrantFiled: January 24, 1985Date of Patent: June 9, 1987Assignee: Oral-DInventor: Donald E. Green
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Patent number: 4668703Abstract: This invention is for .gamma.-allenyl-.gamma.-aminobutyric acid derivatives which are .gamma.-aminobutyric acid transaminase inhibitors.Type: GrantFiled: July 1, 1985Date of Patent: May 26, 1987Assignee: Syntex (U.S.A.) Inc.Inventors: Alexander Krantz, Arlindo L. Castelhano, Diana H. Pliura
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Patent number: 4665229Abstract: The process for preparing hydroxy alkyl amide thio ethers by the reaction of a bicyclic amide acetal with a thiol is described.Type: GrantFiled: February 14, 1985Date of Patent: May 12, 1987Assignee: Ashland Oil, Inc.Inventor: Anil B. Goel
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Patent number: 4665228Abstract: Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 are independently hydrogen, halogen, C.sub.1-6 alkyl, or haloalkyl; R.sub.4 is hydrogen; C.sub.1-4 alkyl, alkenyl, alkoxy, haloalkyl; C.sub.1-2 alkylamino, C.sub.1-2 alkylthio, C.sub.2-4 cycloalkyl, C.sub.2-6 alkoxyalkyl, C.sub.2-6 alkylthiomethyl, amino, phenoxy, phenamino, or furan; and R.sub.5 is hydrogen or C.sub.1-4 alkyl, are useful to retard the growth of turf grass.Type: GrantFiled: April 4, 1986Date of Patent: May 12, 1987Assignee: Monsanto CompanyInventors: Gerhard H. Alt, John P. Chupp, Lane A. Clizbe
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Patent number: 4659857Abstract: The present invention relates to novel cinnamamide compounds and a process for the preparation thereof. The compounds of the invention are useful for controlling insects and acarina.Type: GrantFiled: September 4, 1985Date of Patent: April 21, 1987Assignee: American Cyanamid CompanyInventor: David G. Kuhn
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Patent number: 4657956Abstract: Additives for rubber compositions, giving vulcanizates having improved retention of optimum physical properties, are compounds having the formula R--S--B--S--R where B is an organic bridging group and R is an electron-withdrawing group, for example CN, CCl.sub.3, a radical containing an activated methylene group linked to the sulphur atom or the enolic tautomer of a keto-activated methylene group. Also useful as stabilizing agents are oligomeric analogues of such compounds.Type: GrantFiled: September 13, 1985Date of Patent: April 14, 1987Assignee: Monsanto Europe, S. A.Inventors: Albert F. L. G. Devaux, Philippe G. Moniotte
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Patent number: 4656286Abstract: There are disclosed certain aminoethanethiols, and salts thereof, and certain thiazolidines which are made therefrom. The compounds are useful as intermediates in the synthesis of photographic image dye-providing materials.Type: GrantFiled: May 23, 1986Date of Patent: April 7, 1987Assignee: Polaroid Corporation, Patent Dept.Inventors: Paul T. MacGregor, Myron S. Simon
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Patent number: 4633016Abstract: Compounds corresponding to the general formula ##STR1## wherein R.sup.3 represents H, CH.sub.3R.sup.4 represents H, C.sub.1-12 alkyl, C.sub.1-4 alkoxy, C.sub.1-12 alkylamino, C.sub.7-8 aralkylamino, arylamino, or C.sub.7-20 aralkyl,A represents a two-bonded group having the structure ##STR2## X may represent a single bond or --CO-- if it is attached to a carbon atom but only --CO-- if it is attached to a hetero atom,R.sup.1 represents R.sup.2, H or C.sub.1-4 alkyl,m represents 1 or 2 andn represents an integer from 1 to 12 are suitable as age resisters which can be built into polymers, in particular nitrile rubber.Type: GrantFiled: August 6, 1985Date of Patent: December 30, 1986Assignee: Bayer AktiengesellschaftInventors: Hans-Josef Buysch, Josef Witt, Zsolt Szentivanyi
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Patent number: 4628084Abstract: The present invention provides an improved process for producing 3-acylamino benzodiazepines of the formula: ##STR1## wherein: R is loweralkyl of from 1-6 carbon atoms, aryl such as phenyl and halophenyl, aralkyl, alkyloxy, aralkyloxy, indolyl or substituted indolyl;R' is hydrogen, loweralkyl of from 1-6 carbon atoms, carboxymethyl or carbalkoxymethyl wherein the alkoxy groups contain from 1-4 carbon atoms;X is hydrogen or halogen;Y is hydrogen or halogen.These compounds are useful because of their activity as cholecystokinin (CCK) inhibitors.Type: GrantFiled: January 2, 1986Date of Patent: December 9, 1986Assignee: Merck & Co., Inc.Inventors: Mark G. Bock, Daniel F. Veber, Robert M. DiPardo
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Patent number: 4626571Abstract: A compound of the formula: ##STR1## where p is a whole integer from 1 to 12, and where R.sub.1 is CH.sub.2 OH or CH.sub.2 SH or CHO, m is a whole integer from 1 to 3 and R.sub.2 is H or CH.sub.2 OH. When incorporated into acrylyl-type terpolymers, the above compounds become pendant vicinal dihydroxyalkyl substituents oxidizable by metaperiodate to a pendant aldehyde form. Molecules, including proteins, bearing at least one primary amino group are coupled to the pendant aldehyde groups through Schiff base linkages followed by alkali metal cyanoborohydride reduction of the Schiff base linkages to secondary amine linkages. The study of cell adhesion to and interactions with specific molecule-bearing synthetic cell culture surfaces as well as production of specific molecule-bearing chromatographic media and enzymic reactors are enhanced or made available through the use of the invention's vicinal dihydroxyalkyl bearing acrylyl-type terpolymers.Type: GrantFiled: November 14, 1985Date of Patent: December 2, 1986Assignee: Board of Regents, University of TexasInventor: Paul H. Weigel
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Patent number: 4626581Abstract: A compound of the formula: ##STR1## where p is a whole integer from 1 to 12, and where R.sub.1 is CH.sub.2 OH or CH.sub.2 SH or CHO, m is a whole integer from 1 to 3, and R.sub.2 is H or CH.sub.2 OH. When incorporated into acrylyl-type terpolymers, the above compounds become pendant vicinal dihydroxyalkyl substituents oxidizable by metaperiodate to a pendant aldehyde form. Molecules, including proteins, bearing at least one primary amino group are coupled to the pendant aldehyde groups through Schiff base linkages followed by alkali metal cyanoborohydride reduction of the Schiff base linkages to secondary amine linkages. The study of cell adhesion to and interactions with specific molecule-bearing synthetic cell culture surfaces as well as production of specific molecule-bearing chromatographic media and enzymic reactors are enhanced or made available through the use of the invention's vicinal dihydroxyalkyl bearing acrylyl-type terpolymers.Type: GrantFiled: November 14, 1985Date of Patent: December 2, 1986Assignee: Board of Regents, University of TexasInventor: Paul H. Weigel
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Patent number: 4623729Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.Type: GrantFiled: July 22, 1982Date of Patent: November 18, 1986Assignee: E. R. Squibb & Sons, Inc.Inventors: Sesha I. Natarajan, Eric M. Gordon