Plural Carboxamide Groups Containing Or Containing Plural Carbonyls Bonded Directly To The Same Nitrogen Patents (Class 564/152)
  • Publication number: 20150105587
    Abstract: An amorphous amide compound of the formula wherein R is selected from the group consisting of an alkyl group, an aryl group, an alkylaryl group, an arylalkyl group, and combinations thereof. An amorphous diamide compound of the formula wherein R1 is selected from the group consisting of an alkylene group, an arylene group, an alkylarylene group, an arylalkylene group, and combinations thereof.
    Type: Application
    Filed: October 14, 2013
    Publication date: April 16, 2015
    Applicant: Xerox Corporation
    Inventors: Naveen Chopra, Adela Goredema, Kentaro Morimitsu, Barkev Keoshkerian, Jennifer L. Belelie
  • Patent number: 8962244
    Abstract: The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: February 24, 2015
    Assignee: University of Massachusetts
    Inventor: Sean Ryder
  • Patent number: 8962885
    Abstract: The invention relates to new ?-hydroxyalkylamides, to a method for production of same and to the use of same.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: February 24, 2015
    Assignee: Evonik Degussa GmbH
    Inventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
  • Patent number: 8946459
    Abstract: A process for reacting ethylenediamine-formaldehyde adduct (EDFA) and/or ethylene-diamine-monoformaldehyde adduct (EDMFA) with hydrogen cyanide (HCN) in a reactor with limited backmixing at a temperature in the range from 20 to 120° C., wherein the residence time in the reactor is 300 seconds or less.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: February 3, 2015
    Assignee: BASF SE
    Inventors: Hermann Luyken, Sebastian Ahrens, Gordon Brasche, Jens Baldamus, Robert Baumann, Randolf Hugo, Stephanie Jaegli, Johann-Peter Melder, Jörg Pastre, Boris Buschhaus
  • Publication number: 20150025250
    Abstract: Compounds of the formula I wherein R2a and R2b are independently H, halo, C1-C4alkyl, C1-C4haloalkyl or C1-C4alkoxy, or R2a and R2b together with the carbon atom to which they are attached form a C3-C6cycloalkyl; R3 is a C5-C10 alkyl, optionally substituted with 1-3 substituents independently selected from halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; or R3 is a C2-C4alkyl chain with at least 2 chloro or 3 fluoro substituents; or R3 is C3-C7cycloalkylmethyl, optionally substituted with 1-3 substituents independently selected from C1-C4alkyl, halo, C1-C4haloalkyl, C1-C4alkoxy, C1-C4haloalkoxy; R4 is C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, C1-C6alkylamino, C1-C6dialkylamino or; R4 is Het or Carbocyclyl, either of which is optionally substituted with 1-3 substituents R4 is Het, carbocyclyl, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy or C1-C6haloalkoxy; n is 1, 2 or 3; for the use in the prophylaxis or treatment of a disorder characterised by inappropriate expression or activation of cat
    Type: Application
    Filed: October 2, 2014
    Publication date: January 22, 2015
    Inventors: Susana AYESA, Urszula GRABOWSKA, Ellen HEWITT, Daniel JONSSON, Bjorn KLASSON, Pia KAHNBERG, Stina LUNDGREN, Jan TEJBRANT, Daniel WIKTELIUS
  • Patent number: 8877969
    Abstract: A photosensitive composition comprising: (A) a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation, a pattern forming method using the photosensitive composition, and a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: November 4, 2014
    Assignee: FUJIFILM Corporation
    Inventor: Kenji Wada
  • Patent number: 8853452
    Abstract: Compounds and their syntheses are disclosed herein. Compositions and pharmaceutical compositions comprising a compound are also described, and include compositions also comprising liposomes. Methods for the treatment of cancer in animals comprising administering a compound or a composition comprising a compound are also described.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 7, 2014
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: Barbara S. Beckman, Maryam Foroozesh, Jiawang Liu
  • Publication number: 20140249105
    Abstract: Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them.
    Type: Application
    Filed: July 25, 2011
    Publication date: September 4, 2014
    Applicant: Diverchim
    Inventors: Jean-Louis Brayer, Natacha Frison, Benoit Folleas
  • Patent number: 8821754
    Abstract: The present invention relates to the use of a specific group of alkoxylated and/or acylated non-quaternary nitrogen-containing compounds as anti-agglomerants for gas hydrates. The invention also relates to a method for inhibiting the agglomeration of gas hydrates in a conduit, and compositions comprising the gas hydrate anti-agglomerant, a corrosion inhibitor and/or a paraffin deposition inhibitor.
    Type: Grant
    Filed: March 16, 2007
    Date of Patent: September 2, 2014
    Assignee: Akzo Nobel N.V.
    Inventors: Martin Hellsten, Hans Oskarsson
  • Patent number: 8808438
    Abstract: An amorphous compound for use in phase change ink composition suitable for ink jet printing, including printing on coated paper substrates. In embodiments, the phase change ink composition comprises an amorphous compound and a crystalline compound which is derived from bio-renewable materials. The composition provides for a robust, rapid crystallization ink composition.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: August 19, 2014
    Assignee: Xerox Corporation
    Inventors: Kentaro Morimitsu, Adela Goredema, Naveen Chopra, Jennifer L. Belelie, James D. Mayo
  • Patent number: 8791076
    Abstract: The invention relates to compounds of Formula I: and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, and R3 are defined as set forth in the specification. The compounds are agonists of neurotrophin (such as nerve growth factor) receptors.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: July 29, 2014
    Inventors: Pablo Villoslada, Angel Messeguer
  • Publication number: 20140200368
    Abstract: An amorphous compound for use in phase change ink composition suitable for ink jet printing, including printing on coated paper substrates. In embodiments, the phase change ink composition comprises an amorphous compound and a crystalline compound which is derived from bio-renewable materials. The composition provides for a robust, rapid crystallization ink composition.
    Type: Application
    Filed: January 14, 2013
    Publication date: July 17, 2014
    Applicant: Xerox Corporation
    Inventors: KENTARO MORIMITSU, Adela Goredema, Naveen Chopra, Jennifer L. Belelie, James D. Mayo
  • Publication number: 20140193849
    Abstract: There is provided a glucose-PEG conjugate comprising a PEG moiety conjugated to a linear glucose moiety at the C1 position of the glucose moiety. The glucose-PEG conjugate may be used to reduce glucose transport into a cell and may be used to treat a proliferative disorder.
    Type: Application
    Filed: January 7, 2014
    Publication date: July 10, 2014
    Applicant: Agency for Science, Technology and Research
    Inventors: Karthikeyan Narayanan, Andrew Chwee Aun Wan, Jackie Y. Ying, Nandanan Erathodiyil
  • Patent number: 8729258
    Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: May 20, 2014
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Todd M. Corneillie, Jide Xu
  • Publication number: 20140135401
    Abstract: The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
    Type: Application
    Filed: January 17, 2014
    Publication date: May 15, 2014
    Applicant: CYTOMETIX, INC.
    Inventors: Lane Brostrom, John R. Falck
  • Patent number: 8697194
    Abstract: A substantially colorless radiation overcoat composition suitable for overcoating ink-based images and xerographic-based images. The overcoat composition comprises at least one gellant, at least one monomer, at least one substantially non-yellowing photoinitiator, optionally a curable wax, and optionally a surfactant.
    Type: Grant
    Filed: April 10, 2008
    Date of Patent: April 15, 2014
    Assignee: Xerox Corporation
    Inventors: Peter G. Odell, Jennifer L. Belelie, Michelle N. Chretien, Gordon Sisler, Christopher A. Wagner
  • Patent number: 8686178
    Abstract: The present invention is correlated with a derivative of 18?-glycyrrhetinic acid apt to suppressing cancer cells, which is selected from a group comprising of structure I and structure II: wherein residue R1 is selected from one of CH3 and CH2C6H5, residue R2 is selected from one of COOCH3, COOCH2CH3, COOCH(CH3)2, CONHCH2CH3, CONHCH2CH2CH3, and CONHCH2(CH3)2, and residue R3 is selected from one of COOCH2CH3, COOCH(CH3)2, CONHCH2CH3, CONHCH2CH2CH3, and CONHCH2(CH3)2.
    Type: Grant
    Filed: March 14, 2012
    Date of Patent: April 1, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Chun-Nan Lin, Kai-Wei Lin, A-Mei Huang, Tzyh-Chyuan Hour, Shyh-Chyun Yang, Yeong-Shiau Pu, Jan-Gowth Chang
  • Publication number: 20140073662
    Abstract: The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 13, 2014
    Applicant: Sanofi
    Inventors: Manfred SCHUDOK, Michael WAGNER, Armin BAUER, Anna KOHLMANN
  • Patent number: 8598381
    Abstract: Chelating monomers and fluoride-releasing compositions are disclosed that may be incorporated into dental composite restorative materials, dental bonding agents or other dental materials, to produce materials with high fluoride release rates, and high fluoride recharge capability. Such dental restorative materials may help reduce the level of dental caries in patients, particularly the level of caries occurring on the margins of the restorative materials.
    Type: Grant
    Filed: May 30, 2012
    Date of Patent: December 3, 2013
    Assignee: Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
    Inventors: Xiaoming Xu, Shailaja Jayaramachandran
  • Publication number: 20130267482
    Abstract: Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 10, 2013
    Inventors: Takenao Odagami, Yuji Kogami, Hiroyuki Kouji
  • Patent number: 8541473
    Abstract: A 3-aminooxalylaminobenzamide compound is used as an insecticide or miticide. The 3-aminooxalylaminobenzamide compound is represented by formula [1]: in which, for instance, R1 and R2 each represent a C1 to C3 alkoxy group or a C1 to C3 haloalkoxy group; R3 and R4 each represent a C1 to C8 alkyl group or a C1 to C8 haloalkyl group; R5 represents a C1 to C5 haloalkyl group; R6 and R7 each represent a hydrogen atom or a C1 to C5 alkyl group; Y represents a hydrogen atom or a halogen atom; Z represents a hydrogen atom; n is an integer ranging from 0 to 4; and m is an integer ranging from 0 to 2.
    Type: Grant
    Filed: February 5, 2010
    Date of Patent: September 24, 2013
    Assignee: Agro-Kanesho Co., Ltd.
    Inventors: Shuichi Usui, Toshiki Fukuchi, Sachiko Kinoshita
  • Patent number: 8518999
    Abstract: The present invention provides compounds which are modulators of TNF-? signaling and methods of use thereof for treating a patient having a TNF-? mediated condition.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: August 27, 2013
    Assignee: Genzyme Corporation
    Inventors: Scott F. Sneddon, John L. Kane, Bradford H. Hirth, Fred Vinick, Shuang Qiao, Sharon R. Nahill, John M. Williams, Hans-Peter Biemann
  • Patent number: 8518979
    Abstract: Novel Alpha-halo- and Alpha-alkyl-cyclopropylcarboxy compounds, and uses of these and related compounds in the treatment of a variety of neurological diseases and disorders, and particularly epilepsy, are provided.
    Type: Grant
    Filed: February 19, 2008
    Date of Patent: August 27, 2013
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Meir Bialer, Boris Yagen, Neta Pessah
  • Patent number: 8507612
    Abstract: A crosslinkable, pre-adhesive composition is described comprising an acid-functional (meth)acrylate copolymer and an aziridine crosslinking agent, which when crosslinked provides a pressure-sensitive adhesive and pressure-sensitive adhesive articles.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: August 13, 2013
    Assignee: 3M Innovative Properties Company
    Inventors: Peiwang Zhu, Zhong Chen, Babu N. Gaddam, Larry R. Krepski, Jingjing Ma, David B. Olson, Andrew Satrijo, Dong-Wei Zhu
  • Patent number: 8497306
    Abstract: The invention relates to pharmaceutically acceptable salts of guanylhydrazone-containing compounds, for example, Semapimod. The invention also relates to pharmaceutically acceptable compositions comprising the salts and methods for their use.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: July 30, 2013
    Assignee: Ferring B.V.
    Inventor: Thais M. Sielecki-Dzurdz
  • Patent number: 8492591
    Abstract: Highly selective 5-HT(2C) receptor agonists receptors are disclosed. The 5-HT(2C) receptor agonists are used in the treatments of disease and conditions wherein modulation of 5-HT(2C) receptors provides a benefit, such as obesity and psychiatric disorders.
    Type: Grant
    Filed: February 3, 2011
    Date of Patent: July 23, 2013
    Assignees: The Board of Trustees of the University of Illinois, The University of North Carolina at Chapel Hikll
    Inventors: Alan Kozikowski, Bryan Roth, Andreas Svennebring, Sung Jin Cho
  • Patent number: 8466180
    Abstract: Novel compounds of formula (I): wherein A1, A2, A3, A4, R1, R2, G1, G2, Q1 and Q2 are as defined in claim 1; or salts or N-oxides thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control insect, acarine, mollusc and nematode pests.
    Type: Grant
    Filed: September 7, 2007
    Date of Patent: June 18, 2013
    Assignee: Syngenta Crop Protection LLC
    Inventors: Pierre Joseph Marcel Jung, Stephan Trah, Christopher Richard Ayles Godfrey, William Lutz, Peter Maienfisch, Werner Zambach
  • Publication number: 20130129758
    Abstract: The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.
    Type: Application
    Filed: September 14, 2011
    Publication date: May 23, 2013
    Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
    Inventors: Ramishetti Srinivas, Arup Garu, Sachin B. Agawane, Arabinda Chaudhuri
  • Publication number: 20130115554
    Abstract: A resist composition including a base component (A) which exhibits changed solubility in a developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the base component (A) containing a polymeric compound (A1) having a structural unit (a5) represented by general formula (a5-0) shown below (R1 represents a sulfur atom or an oxygen atom; R2 represents a single bond or a divalent linking group; and Y represents an aromatic hydrocarbon group or an aliphatic hydrocarbon group having a polycyclic group, provided that the aromatic hydrocarbon group or the aliphatic hydrocarbon may have a carbon atom or a hydrogen atom thereof substituted with a substituent.
    Type: Application
    Filed: November 6, 2012
    Publication date: May 9, 2013
    Applicant: Tokyo Ohka Kogyo Co., Ltd.
    Inventor: Tokyo Ohka Kogyo Co., Ltd.
  • Publication number: 20130109752
    Abstract: The present invention is correlated with a derivative of 18?-glycyrrhetinic acid apt to suppressing cancer cells, which is selected from a group comprising of structure I and structure II: wherein residue R1 is selected from one of CH3 and CH2C6H5, residue R2 is selected from one of COOCH3, COOCH2CH3, COOCH(CH3)2, CONHCH2CH3, CONHCH2CH2CH3, and CONHCH2(CH3)2, and residue R3 is selected from one of COOCH2CH3, COOCH(CH3)2, CONHCH2CH3, CONHCH2CH2CH3, and CONHCH2(CH3)2.
    Type: Application
    Filed: March 14, 2012
    Publication date: May 2, 2013
    Inventors: Chun-Nan Lin, Kai-Wei Lin, A-Mei Huang, Tzyh-Chyuan Hour, Shyh-Chyun Yang, Yeong-Shiau Pu, Jan-Gowth Chang
  • Publication number: 20130085286
    Abstract: A process for preparing amines of the formula (II) R1—NH—CH2—CH2—NH2??(II) in which R1 is hydrogen or radicals of the formula x is integers from zero to two, by reacting nitriles of the formula (I) R2—NH—CH2—CN??(I) in which R2 is hydrogen or radicals of the formula and R3 is the NC— or H2N—CH2- radicals and x is integers from zero to two, with hydrogen in the presence of a catalyst in suspension mode or in a fixed bed, wherein the space velocity on the catalyst, based on the catalyst surface area, is 10?6 to 10?4 kg of nitrile of the formula (I) per m2 of catalyst surface area and hour, the catalyst surface area being determined by the BET method.
    Type: Application
    Filed: August 31, 2012
    Publication date: April 4, 2013
    Applicant: BASF SE
    Inventors: Hermann Luyken, Sebastian Ahrens, Gordon Brasche, Jens Baldamus, Robert Baumann, Randolf Hugo, Stephanie Jaegli, Johann-Peter Melder, Jõrg Pastre, Boris Buschhaus
  • Publication number: 20130079492
    Abstract: A process for preparing EDDN and/or EDMN by conversion of FA, HCN and EDA, the reaction being effected in the presence of water, and, after the conversion, water being depleted from the reaction mixture in a distillation column, which comprises performing the distillation in the presence of an organic solvent which has a boiling point between water and EDDN and/or EDMN at the distillation pressure existing in the column or which forms a low-boiling azeotrope with water.
    Type: Application
    Filed: August 30, 2012
    Publication date: March 28, 2013
    Applicant: BASF SE
    Inventors: Hermann Luyken, Sebastian Ahrens, Gordon Brasche, Jens Baldamus, Robert Baumann, Randolf Hugo, Stephanie Jaegli, Johann-Peter Melder, Jörg Pastre, Boris Buschhaus
  • Publication number: 20130065963
    Abstract: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
    Type: Application
    Filed: July 17, 2012
    Publication date: March 14, 2013
    Applicant: Georgetown University
    Inventors: Alan P. Kozikowski, Anatoly Dritschilo, Mira Jung, Pavel A. Petukhov, Bin Chen
  • Publication number: 20130053536
    Abstract: A process for preparing EDDN and/or EDMN by a) conversion of FA, HCN and EDA, the conversion being effected in the presence of water, b) depleting water from the reaction mixture obtained in stage a), and c) treating the mixture from stage b) with an absorbent in the presence of an organic solvent, wherein the adsorbent is a solid acidic adsorbent.
    Type: Application
    Filed: August 30, 2012
    Publication date: February 28, 2013
    Applicant: BASF SE
    Inventors: Hermann Luyken, Sebastian Ahrens, Gordon Brasche, Jens Baldamus, Robert Baumann, Randolf Hugo, Stephanie Jaegli, Johann-Peter Melder, Jörg Pastre, Boris Buschhaus
  • Publication number: 20130053584
    Abstract: A process for reacting ethylenediamine-formaldehyde adduct (EDFA) and/or ethylene-diamine-monoformaldehyde adduct (EDMFA) with hydrogen cyanide (HCN) in a reactor with limited backmixing at a temperature in the range from 20 to 120° C., wherein the residence time in the reactor is 300 seconds or less.
    Type: Application
    Filed: August 30, 2012
    Publication date: February 28, 2013
    Applicant: BASF SE
    Inventors: Hermann Luyken, Sebastian Ahrens, Gordon Brasche, Jens Baldamus, Robert Baumann, Randolf Hugo, Stephanie Jaegli, Johann-Peter Melder, Jörg Pastre, Boris Buschhaus
  • Publication number: 20130052149
    Abstract: The disclosed invention relates to a process, comprising: conducting unit operations in at least two process zones in a process microchannel to treat and/or form a non-Newtonian fluid, a different unit operation being conducted in each process zone; and applying an effective amount of shear stress to the non-Newtonian fluid to reduce the viscosity of the non-Newtonian fluid in each process zone, the average shear rate in one process zone differing from the average shear rate in another process zone by a factor of at least about 1.2.
    Type: Application
    Filed: October 4, 2012
    Publication date: February 28, 2013
    Applicant: VELOCYS, INC.
    Inventor: Velocys, Inc.
  • Patent number: 8377639
    Abstract: The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: February 19, 2013
    Assignee: University of Massachusetts
    Inventor: Sean Ryder
  • Publication number: 20130023510
    Abstract: The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.
    Type: Application
    Filed: May 25, 2012
    Publication date: January 24, 2013
    Applicant: Cytometix, Inc.
    Inventors: Lane Brostrom, John R. Falck
  • Patent number: 8350100
    Abstract: In a process for the preparation of ring compounds via a combinatorial synthesis, the reaction procedure is based on a Suzuki coupling; subsequent halo-demetallation and finally a further Suzuki coupling. The Suzuki couplings are each carried out with a boronic acid or a boronic acid ester. The reaction procedure uses provides novel ring compounds and uses novel synthesis units used for this purpose. The novel ring compounds are suitable for use as constituents in liquid-crystalline mixtures.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: January 8, 2013
    Assignee: Merck Patent GmbH
    Inventors: Detlef Pauluth, Peer Kirsch, Peter Baeuerle, Oliver Deeg
  • Publication number: 20130006016
    Abstract: The invention relates to novel ?-hydroxyalkylamides, to a method for their production and to the use thereof.
    Type: Application
    Filed: March 10, 2011
    Publication date: January 3, 2013
    Applicant: Evonik Degussa GmbH
    Inventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
  • Patent number: 8309507
    Abstract: The invention is directed to a fluid detergent composition comprising a di-amido gellant and a surfactant, and a method for structuring said composition.
    Type: Grant
    Filed: February 27, 2012
    Date of Patent: November 13, 2012
    Assignee: The Procter & Gamble Company
    Inventors: Susana Fernandez Prieto, Johan Smets, Beatriu Escuder Gil, Juan Felipe Miravet Celades, Vincent Josep Nebot Carda
  • Publication number: 20120264802
    Abstract: The present invention relates to photosensitizer compounds based on functionalized fullerenes useful in targeted photodynamic therapy (PDT), and methods of use thereof.
    Type: Application
    Filed: May 31, 2012
    Publication date: October 18, 2012
    Applicants: Lynntech, Inc., The General Hospital Corporation
    Inventors: Tim Wharton, Hariprasad Gali, Michael R. Hamblin
  • Publication number: 20120238676
    Abstract: Oligomeric carbodiimides comprising at least one heterocyclic end group are used as stabilizers for polymers. The oligomeric carbodiimides may be compounds of the general formula (I), where A1, A2 are each independently, identically or differently, hydrocarbon groups having 2 to 20 carbon atoms, B1, B2 are each independently, identically or differently, heterocycles, C1-C30-alcohols, polyetherols, polyesterols, amines, polyether amines, polyester amines, thioalcohols, polyether thiols, polyester thiols, R1, R2 are each independently, identically or differently, n is an integer from 2 to 100, and wherein A1, A2, B1 and B2 may each be substituted at any desired position by C1-C20-alkyl, C2-C20-alkenyl, C2-C20-alkynyl, C1-C20-alkoxy, carbonyl oxygen (?O) or halogen, with the proviso that at least one B1 or B2 substituent is a heterocyclic end group. Processes for stabilizing polymers against hydrolysis using oligomeric carbodiimides are also disclosed.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Applicant: BASF SE
    Inventors: THEO SMIT, LAURENCE POTTIE, SIMONE SCHILLO, VOLKER FRENZ, ROELOF VAN DER MEER
  • Publication number: 20120208956
    Abstract: The invention relates to new ?-hydroxyalkylamides, to a method for production of same and to the use of same.
    Type: Application
    Filed: March 10, 2011
    Publication date: August 16, 2012
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Werner Grenda, Emmanouil Spyrou, Thomas Weihrauch, Christoph Lammers, Holger Loesch, Klaus Behrendt
  • Patent number: 8236748
    Abstract: The invention is to pH tunable amido-gellant that are suitable for use in consumer product compositions.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: August 7, 2012
    Assignee: The Procter & Gamble Company
    Inventors: Susana Fernandez Prieto, Johan Smets, Beatriu Escuder Gil, Juan Felipe Miravet Celades, Vincent Josep Nebot Carda
  • Patent number: 8227610
    Abstract: The disclosure provides, in part, compositions of perfluoro polyether compounds and associated methods for producing cellular labels for tracking cells by MRI and methods for labeling, detecting and quantifying cell numbers in vivo.
    Type: Grant
    Filed: July 10, 2008
    Date of Patent: July 24, 2012
    Assignee: Carnegie Mellon University
    Inventors: Jelena Janjic, Eric T. Ahrens
  • Patent number: 8207107
    Abstract: The invention is to di-amido gellant that are suitable for use in consumer product compositions.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: June 26, 2012
    Assignee: The Procter & Gamble Company
    Inventors: Susana Fernandez Prieto, Johan Smets, Beatriu Escuder Gil, Juan Felipe Miravet Celades, Vincent Josep Nebot Carda
  • Patent number: 8173800
    Abstract: The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
    Type: Grant
    Filed: August 15, 2007
    Date of Patent: May 8, 2012
    Assignee: The Regents of the University of California
    Inventors: Kenneth N. Raymond, Todd M. Corneillie, Jide Xu
  • Patent number: 8168579
    Abstract: The invention is directed to a fluid detergent composition comprising a di-amido gellant and a surfactant, and a method for structuring said composition.
    Type: Grant
    Filed: March 11, 2011
    Date of Patent: May 1, 2012
    Assignee: The Procter and Gamble Company
    Inventors: Susana Fernandez Prieto, Johan Smets, Beatriu Escuder Gil, Juan Felipe Miravet Celades, Vincent Josep Nebot Carda
  • Patent number: RE43327
    Abstract: The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: April 24, 2012
    Assignee: Aminex Therapeutics, Inc.
    Inventors: Mark R. Burns, Gerard F. Graminski, Nand Baindur