Hydroxy, Bonded Directly To Carbon, Or Ether Containing (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/158)
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Patent number: 4382954Abstract: Compounds represented by the formula ##STR1## wherein R and R.sup.1 are independently hydrogen or lower alkyl; R.sup.2 is lower alkenyl, lower alkynyl or --CH.sub.2 X wherein X is halogen, hydroxyl, lower alkoxy, lower alkylthio or a furanyl ring; and Z is hydroxyl, lower alkoxy or --NR.sup.3 R.sup.4 wherein R.sup.3 and R.sup.4 are independently hydrogen or lower alkyl possess fungicidal activity. Moreover, some of the compounds of this invention also possess herbicidal activity.Type: GrantFiled: January 27, 1982Date of Patent: May 10, 1983Assignee: Chevron Research CompanyInventor: David C. K. Chan
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Patent number: 4370486Abstract: Biphenyl compounds of the formula ##STR1## in which the substituents have the meanings given in the description,are obtained by amidomethylation of the corresponding starting compounds and, if appropriate, subsequent sulphonation. The new compounds are used, for example, for the preparation of dyestuff precursors, dyestuffs, plastics and medicaments.Type: GrantFiled: August 14, 1981Date of Patent: January 25, 1983Assignee: Bayer AktiengesellschaftInventor: Horst Harnisch
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Patent number: 4370318Abstract: 3-Amino-2-hydroxy-4-phenylbutanoic acid and esters thereof as well as new derivatives thereof which are related to bestatin in their chemical structure are active to enhance the immune response in living animals.Type: GrantFiled: June 10, 1981Date of Patent: January 25, 1983Assignee: Zaidan Hojin Biseibutsu Kagaku Kenkyu KaiInventors: Hamao Umezawa, Tomio Takeuchi, Takaaki Aoyagi, Kenji Kawamura, Shunzo Fukatsu
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Patent number: 4362546Abstract: Tetrahydrophthalamide derivatives of the general formula: ##STR1## wherein X.sub.1 is hydrogen or halogen; X.sub.2 is halogen, alkoxy or substituted benzyloxy; X.sub.3 is hydrogen, alkoxy or alkenyloxy; R and R' are the same or different alkyl, cycloalkyl, alkenyl or phenyl, each of which may be optionally substituted, or may jointly, together with nitrogen atom adjacent to R and R', form aliphatic heterocyclic ring containing one or two nitrogens or nitrogen and oxygen, which have a herbicidal activity against a broad spectrum of monocotyledonous and dicotyledonous weeds.Type: GrantFiled: May 27, 1980Date of Patent: December 7, 1982Assignee: Takeda Chemical Industries, Ltd.Inventor: Hiroshi Nagase
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Patent number: 4353834Abstract: Biodegradable non-ionic surface-active agents containing carbonate groups can be prepared by reacting hydrophilic polyoxyalkylene glycols derived from the same or different alkylene oxides with hydrophobic amides or sulfonamides. The compositions of the invention contain both hydrophilic and hydrophobic groups in the molecule making them suitable for use as surface-active agents.Type: GrantFiled: March 13, 1981Date of Patent: October 12, 1982Assignee: BASF Wyandotte CorporationInventor: William K. Langdon
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Patent number: 4352760Abstract: The present invention provides novel substituted heptadeca-5,9- and 5,10-dienoic acid and similar fatty acid compounds which are derivatives of certain prostaglandins and are potent thromboxane A.sub.2 inhibitors. By virtue of this pharmacological property, they represent useful pharmacological agents for a wide variety of purposes.Type: GrantFiled: December 29, 1980Date of Patent: October 5, 1982Assignee: The Upjohn CompanyInventor: Kirk M. Maxey
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Patent number: 4349689Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: September 14, 1982Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4349690Abstract: The present invention provides novel 9-deoxy-9-methylene-6-keto-PGE derivatives which are useful for platelet aggregation inhibition and gastric cyctoprotection.Type: GrantFiled: April 23, 1981Date of Patent: September 14, 1982Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4339393Abstract: The distyrylbiphenyls of the formula ##STR1## in which X and X' independently of one another are a direct bond, oxygen, sulfur, --O--C.sub.1--3 --alkylene--CON(R.sub.4)--, --CON(R.sub.4)--,--O--C.sub.1--3 --alkylene--COO--, OCO or --COO--, with the proviso that if n+n'=O, X and X' may not be --CON(R.sub.4)--or O--C.sub.1--3 --alkylene--CON(R.sub.4)--, and if n+n'=2 and X and X' are --CON(R.sub.4)--or --COO--, A.crclbar. may not be a phosphite or phosphonate anion, and Y and Y' independently of one another are C.sub.1--20 --alkylene, R.sub.1 and R.sub.1' independently of one another are unsubstituted or substituted C.sub.1--8 --alkyl or C.sub.3--4 --alkenyl, or R.sub.1 together with R.sub.2, or R.sub.1' together with R.sub.2', is a heterocyclic ring, R.sub.2 and R.sub.2' independently of one another are unsubstituted or substituted C.sub.1--8 --alkyl or C.sub.3--4 -- alkenyl, or R.sub.2 together with R.sub.1, or R.sub.2' together with R.sub.1', is a heterocyclic ring, or R.sub.1 and R.sub.2, or R.sub.1' and R.Type: GrantFiled: April 4, 1980Date of Patent: July 13, 1982Assignee: Ciba-Geigy CorporationInventors: Christian Luthi, Hans R. Meyer, Kurt Weber
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Patent number: 4338457Abstract: The present invention relates to novel compositions of matter and novel processes for preparing these compositions of matter. Moreover, there are provided novel methods by which certain of these novel compositions of matter are employed for pharmacologically useful purposes.Type: GrantFiled: February 28, 1980Date of Patent: July 6, 1982Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4330323Abstract: The compounds of the formula: ##STR1## in which R.sub.1 represents a dichloromethyl or trichloromethyl group, X.sub.1 represents a chlorine or fluorine atom, X.sub.2 represents a chlorine or fluorine atom, X.sub.3 represents a hydrogen, chlorine or fluorine atom, R.sub.2 represents an amino group NH.sub.2 or a ##STR2## group, in which R.sub.3 represents a hydrogen atom or an alkyl, haloalkyl, alkenyl, haloalkenyl, arylalkyl, arylhaloalkyl, cycloalkyl, halocycloalkyl, alkoxyalkyl, haloalkoxyalkyl or aryl group, this latter being unsubstituted or substituted by one or two halogen atoms or by an alkyl, alkoxy, nitro or haloalkyl group are antidotes against herbicides.Type: GrantFiled: May 25, 1979Date of Patent: May 18, 1982Assignee: PCUK Produits Chimiques Ugine KuhlmannInventors: Bernard S. J. M. Gorny, Jean-Paul Brun, Gerard E. M. Boutemy, Michel L. Devif
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Patent number: 4328367Abstract: Novel tetrahydrophthalamide derivatives of the general formula: ##STR1## wherein X is chlorine or bromine, and R is hydrogen, or an alkyl, a substituted alkyl, a cycloalkyl, a substituted cycloalkyl, an alkenyl, or an alkynyl group, have strong herbicidal activity and are particularly, useful for selectively controlling weeds without causing any substantial injury to soybean and other crop plants.Type: GrantFiled: November 27, 1978Date of Patent: May 4, 1982Assignee: Takeda Chemical Industries, Ltd.Inventor: Hiroshi Nagase
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Patent number: 4314055Abstract: Certain 3,5-disubstituted-2,4,6-triiodoanilides of polyhydroxy-monobasic acids are useful as x-ray contrast agents. Representative of this class of compounds is the compound 3-gluconamido-2,4,6-triiodo-N-methyl-5-(N-methyl-acetamido)-benzamide and the compound 3-gluconamido-5-[N-(2-hydroxyethyl)acetamido]-2,4,6-triiodo-N-methylbenzam ide.Type: GrantFiled: March 29, 1977Date of Patent: February 2, 1982Assignee: Mallinckrodt, Inc.Inventors: George B. Hoey, George P. Murphy, Philip E. Wiegert, James W. Woods
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Patent number: 4310693Abstract: o-Aminophenol derivatives are described represented by the formula (I) ##STR1## wherein R represents --NH.sub.2 or --NH--CO--R.sup.6 ; R.sup.1 and R.sup.2 which may be the same or different, each can represent an alkyl group or an aromatic group, or R.sup.1 and R.sup.2 together can form a ring; or R.sup.1, R.sup.2 and R.sup.3 together can form a ring ; R.sup.3 represents hydrogen, an alkyl group or an aromatic group; R.sup.4 can represent an alkyl group or an aromatic group; R.sup.5 can represent an alkyl group, an alkoxy group, an alkylthio group, an arylthio group, a halogen atom or an acylamino group; and n is 0, 1 or 2; R.sup.6 represents an alkyl group or an aromatic group; and R.sup.4 and R.sup.5 together can form a heterocyclic ring, R.sup.1 and R.sup.4 together can form a heterocyclic ring, or R.sup.1 and R.sup.5 together can form a ring; and R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5.sub.n have a total of 7 or more carbon atoms.Type: GrantFiled: July 18, 1980Date of Patent: January 12, 1982Assignee: Fuji Photo Film Co., Ltd.Inventors: Shinsaku Fujita, Koichi Koyama, Yoshio Inagaki
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Patent number: 4307112Abstract: 9-deoxy-9A-methylene-isosteres of PGI.sub.2, including processes for their preparation and pharmaceutical and veterinary compositions containing same, are disclosed. The compounds are useful as therapeutic agents, for example as anti-aggregating agents, disaggregating agents, and as vasodilators.Type: GrantFiled: February 26, 1980Date of Patent: December 22, 1981Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Carmelo Gandolfi, Carlo Passarotti, William Fava, Angelo Fumagalli, Franco Faustini, Roberto Ceserani
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Patent number: 4307072Abstract: Nonionic triiodobenzoyl amino acyl derivatives of polyhydroxy amines. Such amines are useful as nonionic X-ray contrast agents. For Example 2-(3-acetamido-2,4,6-triiodo-5-N-methylacetamidobenzoyl glycylamino)-2-deoxy-D-glucitol is especially useful in angiography.Type: GrantFiled: July 19, 1977Date of Patent: December 22, 1981Assignee: Mallinckrodt, Inc.Inventor: Kenneth R. Smith
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Patent number: 4306075Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet antiaggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 15, 1981Assignee: The Upjohn CompanyInventor: Paul A. Aristoff
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Patent number: 4306076Abstract: The present specification provides novel analogs of carbacyclin (CBA.sub.2), 6a-carba-prostacyclin (6a-carba-PGI.sub.2), which have pronounced prostacyclin-like pharmacological activity, e.g., as platelet anti-aggregatory agents. Specifically the novel chemical analogs of CBA.sub.2 are those substituted by fluoro (C-5), alkyl (C-9), interphenylene (C-5), and methano (C-6a,9). Further provided are benzindene analogs of CBA.sub.2 and substituted forms thereof, i.e., 9-deoxy-2',9-methano (or 2',9-metheno)-3-oxa-4,5,6-trinor-3,7-(1',3'-interphenylene)-PGF.sub.1 compounds. Also provided are a variety of novel chemical intermediates, e.g., substituted bicyclo[3.3.0]octane intermediates, and chemical process utilizing such intermediates which are useful in the preparation of the novel CBA.sub.2 analogs.Type: GrantFiled: December 22, 1980Date of Patent: December 15, 1981Assignee: The Upjohn CompanyInventor: Norman A. Nelson
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Patent number: 4306080Abstract: A novel process for the purification of industrial effluents, wherein the effluents are brought into contact with cationically modified, cellulose-containing materials, the cationic constituent of which is bonded to the cellulose part via the grouping of the general formula--O--CH.sub.2 --N<in which the nitrogen belongs to an amide group of the cationic constituent and the oxygen is bonded to the cellulose part.Type: GrantFiled: February 9, 1979Date of Patent: December 15, 1981Assignee: Ciba-Geigy CorporationInventors: Jaroslav Haase, Peter Liechti, Hans Wegmuller, Rudolf F. Wurster, Quentin Bowes
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Patent number: 4303673Abstract: The invention provides N-propionylsarcosineanilides of the formula: ##STR1## wherein n is an integer of 1 to about 3 and the substituent A which can be the same or different when n is greater than 1 is selected from the group consisting of trifluoromethyl; halogen; nitro; acetyl; a straight-chain or branched alkyl group having 1 to 4 carbon atoms; a straight-chain or branched alkoxy group having 1 to 4 carbon atoms; a straight-chain or branched alkylmercapto group having 1 to 7 carbon atoms; a substituted alkylmercapto group of the formula: ##STR2## wherein n is an integer of 1 or 2, R.sub.1 can represent hydrogen and methyl, and R.sub.2 can represent hydroxyl, and an amino group of the formula:--NR.sub.6 R.sub.7 Vwherein R.sub.6 can represent hydrogen, and methyl, and R.sub.7 can represent methyl, substituted benzyl, and R.sub.6 and R.sub.7, together with the nitrogen, can constitute a substituted pyrrolidine ring; a sulphonyl group of the formula:--SO.sub.2 R.sub.3 IIIwherein R.sub.Type: GrantFiled: September 5, 1980Date of Patent: December 1, 1981Assignee: A. Nattermann & Cie. GmbHInventors: Jurgen Biedermann, Armin Wendel, Hans Betzing, Volker Neuser
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Patent number: 4302472Abstract: Substituted N-(.beta.-Alkoxy-Ethyl)-N-(4-Phenoxy Benzyl)-Dichoroacetamides are provided for the chemotherapeutic treatment of amebiasis.Type: GrantFiled: August 1, 1979Date of Patent: November 24, 1981Assignee: Farmitalia Carlo Erba S.p.A.Inventors: Paolo Cozzi, Piero Menchetti, Ivo de Carneri, Franca Trane
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Patent number: 4296253Abstract: The present invention provides 2,5-inter-o-phenylene-3,4-dinor-PGF.sub.2 amides. These compounds are intermediates for preparing 2,5-inter-o-phenylene-3,4-dinor-prostacyclin analogs, which are useful for pharmacological purposes, e.g., as antithrombotic agents.Type: GrantFiled: July 3, 1980Date of Patent: October 20, 1981Assignee: The Upjohn CompanyInventors: Udo F. Axen, John C. Sih
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Patent number: 4268669Abstract: The present invention particularly relates to novel 9-deoxy-9-methylene-5,6-didehydro-PGF.sub.1 amides and methods for their preparation in pharmacological use.Type: GrantFiled: January 28, 1980Date of Patent: May 19, 1981Assignee: The Upjohn CompanyInventor: Gordon L. Bundy
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Patent number: 4246198Abstract: A phenol of the formulae I, II or III ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are independent of one another and one of these is C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl or C.sub.7 -C.sub.9 -aralkyl and the others are hydrogen, C.sub.1 -C.sub.12 -alkyl or C.sub.5 -C.sub.6 -cycloalkyl, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are independent of one another and one of these is C.sub.1 -C.sub.12 -alkyl or C.sub.5 -C.sub.6 -cycloalkyl and the others are hydrogen, C.sub.1 -C.sub.12 -alkyl or C.sub.5 -C.sub.6 cycloalkyl, or R.sub.4 and R.sub.5, or R.sub.6 and R.sub.7, together with the C atom which links them, form a 5-12-membered ring, R.sub.8, R.sub.9 and R.sub.10 are independent of one another and one of these is C.sub.1 -C.sub.12 -alkyl, C.sub.5 -C.sub.6 -cycloalkyl or C.sub.7 -C.sub.9 -aralkyl and the others are hydrogen, C.sub.1 -C.sub.12 -alkyl or C.sub.5 -C.sub.Type: GrantFiled: May 10, 1979Date of Patent: January 20, 1981Assignee: Ciba-Geigy CorporationInventors: Siegfried Rosenberger, Andreas Schmidt
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Patent number: 4244887Abstract: Substituted novel .omega.-pentanorprostaglandins and various novel intermediates and reagents used in their preparation.Type: GrantFiled: August 20, 1979Date of Patent: January 13, 1981Assignee: Pfizer Inc.Inventors: Jasjit S. Bindra, Michael R. Johnson
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Patent number: 4243653Abstract: Non-ionic polyiodo saccharidic ether substituted anilines are provided as contrast media, the ether being non-glycosidyl. The compounds have excellent physical properties in having acceptable water solubility or capable of stable suspension, relatively low osmotic pressure, good thermal stability, so as to be heat sterilizable, and a high iodine proportion. The compounds can be prepared from polynitroaromatics by substitution and reduction.Type: GrantFiled: April 27, 1979Date of Patent: January 6, 1981Assignee: The Regents of the University of CaliforniaInventors: Milos Sovak, Ramachandra Ranganathan