Abstract: The invention relates to new 2-ketosulfonamides of the general formula ##STR1## and to a process for their preparation, which process comprises oxidizing compounds of the general formulaR--CHOH--CH.sub.2 --SO.sub.2 NH.sub.2with manganese dioxide in a readily volatile, oxidation-stable organic solvent, preferably acetone or acetonitrile.
Abstract: 9-deoxy-9A-methylene-isosteres of PGI.sub.2, including processes for their preparation and pharmaceutical and veterinary compositions containing same, are disclosed. The compounds are useful as therapeutic agents, for example as anti-aggregating agents, disaggregating agents, and as vasodilators.
Type:
Grant
Filed:
February 26, 1980
Date of Patent:
December 22, 1981
Assignee:
Farmitalia Carlo Erba S.p.A.
Inventors:
Carmelo Gandolfi, Carlo Passarotti, William Fava, Angelo Fumagalli, Franco Faustini, Roberto Ceserani
Abstract: There is disclosed methods and compositions for inhibiting or preventing the growth of microorganisms in aqueous systems wherein the growth is inhibited or prevented by the presence of an effective amount of a 2-chloro-3-oxobutyramide derivative.
Type:
Grant
Filed:
November 8, 1979
Date of Patent:
January 27, 1981
Assignees:
Givaudan Corporation, Hoffmann-La Roche Inc.
Inventors:
Harold A. Brandman, Milton Manowitz, David L. Coffen
Abstract: A process for the production of .alpha.-monochloroacetoacetic acid monomethylamide is disclosed which comprises chlorinating acetoacetic acid monomethylamide in the presence of urea and a water-soluble alkali metal salt or ammonium salt at a temperature of between -20.degree. and +10.degree. C. with 80-95% of the equivalent amount of chlorine; neutralizing the reaction mixture; separating the precipitated .alpha.-monochloroacetoacetic acid monomethylamide; and partially recycling the mother liquor back into the chlorination process. .alpha.-Chloroacetoacetic acid monomethylamide is a valuable intermediate for producing insecticidal active compounds, for example dimethyl-1-methyl-2-(methylcarbamoyl)-vinyl phosphate.