Hydroxy, Bonded Directly To Carbon, Or Ether In Substituent Q (h Of -oh May Be Replaced By A Substituted Or Unsubstituted Ammonium Ion Or A Group Ia Or Iia Light Metal) Patents (Class 564/201)
  • Patent number: 8981150
    Abstract: Novel ether-amide compounds are described. Uses of the compounds, in particular as solvents, for example in phytosanitary formulations are also described.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: March 17, 2015
    Assignee: Rhodia Operations
    Inventors: Thierry Vidal, Massimo Guglieri, Olivier Jentzer
  • Patent number: 8969621
    Abstract: Novel ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 and processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: March 3, 2015
    Assignee: Rhodia Operations
    Inventors: Massimo Guglieri, Olivier Jentzer
  • Publication number: 20140364648
    Abstract: Ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 are described. Also described, are processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.
    Type: Application
    Filed: August 26, 2014
    Publication date: December 11, 2014
    Inventors: Massimo GUGLIERI, Olivier JENTZER
  • Patent number: 8697912
    Abstract: The present invention relates to an N-(1-hydroxyethyl)carboxamide compound represented by formula (1) (in the formula, RA and RB represent independently from each other a hydrogen atom or an alkyl group having 1 to 4 carbon atoms except for a case where RA and RB represent a hydrogen atom at the same time) and a method for producing the same; a method for producing an N-(1-alkoxyethyl)carboxamide compound; a method for producing an N-vinyl carboxylic acid amide compound; and a method for producing an N-vinyl carboxylic acid amide (co)polymer. An N-(1-alkoxyethyl)carboxamide compound can be obtained by reacting N-(1-hydroxyethyl)carboxamide compound with alcohol in the presence of an acid catalyst, and an N-vinyl carboxylic acid amide compound, which is a monomer of the N-vinyl carboxylic acid amide (co)polymer, can be obtained by thermally decomposing or catalytically decomposing the N-(1-alkoxyethyl)carboxamide compound.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: April 15, 2014
    Assignee: Showa Denko K.K.
    Inventors: Keisuke Ohta, Syunichi Nagamatsu, Tetsuya Ishii
  • Publication number: 20130345470
    Abstract: A process for producing high purity 3-hydroxypropionic acid from a fermentation cell broth is described. The 3-hydroxypropionic acid can be converted to a variety of products, such as acrylamide, 3-hydroxypropionic esters, acrylic esters, and 3-HP amide. This process features a high degree of product flexibility, limited or no solvent recycle, discrete waste streams, an efficient water removal process, and efficient recovery of products and solvents with proven and scalable equipment.
    Type: Application
    Filed: June 20, 2012
    Publication date: December 26, 2013
    Applicant: OPX Biotechnologies, Inc.
    Inventors: Robert Tengler, David DeCoster
  • Publication number: 20130287955
    Abstract: The present invention describes the highly advantageous properties of a mixture of thiol-perfluoropolyether (PFPE) molecules with perfluorinated bisphosphonic (PF-BP) compounds. This mixture makes it possible in effect to obtain a lipophobic behaviour (also referred to as “epilame” effect) with common watch-making lubricants on all the materials tested, including metals, inter alia gold and alloys thereof, ceramics and semiconductors, and gives the surface treated a good resistance to ageing and to cleaning products.
    Type: Application
    Filed: December 21, 2011
    Publication date: October 31, 2013
    Inventors: David Portet, Gregory Lecollinet
  • Publication number: 20130281664
    Abstract: The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e.
    Type: Application
    Filed: October 11, 2011
    Publication date: October 24, 2013
    Inventors: David Milstein, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang
  • Patent number: 8530521
    Abstract: A compound having the structure wherein Y is selected from the group consisting of —C(O)OR2, —C(O)NHR8, —C(CH2)1-2OR3, OH, and or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: September 10, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Amjad Ali, Robert K. Baker, Kathleen M. Rupprecht, Michael Man-Chu Lo, Brent Whitehead
  • Publication number: 20130189287
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs.
    Type: Application
    Filed: December 21, 2012
    Publication date: July 25, 2013
    Applicants: Innate Pharma
    Inventors: Innate Pharma, Paul Scherrer Institut
  • Publication number: 20130178540
    Abstract: The present invention provides sulfoxide compounds comprising hydrophobic ester or amide moieties such that the compounds have surfactant properties. Also provided are methods for using the sulfoxide compounds or mixtures of the sulfoxide compounds in a variety of applications.
    Type: Application
    Filed: December 28, 2012
    Publication date: July 11, 2013
    Applicants: BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA, NOVUS INTERNATIONAL INC.
    Inventors: NOVUS INTERNATIONAL INC., Board of Regents of the University of Oklahoma
  • Patent number: 8440860
    Abstract: A process for manufacturing dialkyl lactamide including reacting lactide and dialkylamine selected from one or more of dimethylamine, diethylamine, and methylethylamine to form a reaction mixture which includes dialkyl lactamide selected from N,N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide, N,N-dialkyl lactoyl lactamide, and dialkylamine, subjecting the reaction mixture to a separation step to form a product stream including N,N-dialkyl lactamide, a first recycle stream including dialkylamine and a second recycle stream including N,N-dialkyl lactoyl lactamide, feeding the recycle streams to the reaction step, and isolating the product stream. The process allows the manufacture of N,N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide on a commercial scale.
    Type: Grant
    Filed: September 30, 2009
    Date of Patent: May 14, 2013
    Assignee: Purac Biochem BV
    Inventor: Jan Van Krieken
  • Patent number: 8420859
    Abstract: This invention relates to the use of lactamide compounds of formula (I): CH3CH(OH)C(?O)NR1R2, where R1 and R2 are each independently hydrogen; or C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl, each of which is optionally substituted by up to three substituents independently selected from phenyl, hydroxy, C1-5 alkoxy, morpholinyl and NR3R4 where R3 and R4 are each independently C1-3 alkyl; or phenyl optionally substituted by up to three substituents independently selected from C1-3 alkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl, pyrrolidinyl, piperidinyl or azepanyl ring, each of which is optionally substituted by up to three substituents independently selected from C1-3 alkyl, in formulations to reduce the toxicity associated with other formulation components; to the use of certain lactamide compounds as solvents, especially in formulations, particularly in agrochemical formulations and in environmentally friendly formulations; to novel lactamide compounds; and
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: April 16, 2013
    Assignee: Syngenta Limited
    Inventors: Gordon Bell, Ian David Tovey
  • Publication number: 20130053342
    Abstract: The invention relates to the cosmetic use, as a skin moisturizer, of a compound of formula (I): with (i) R1 and R2 represent a hydrogen atom or a C1-C6 alkyl group, or (ii) R1 and R2 can form, together with the nitrogen atom which bears them, a saturated heterocycle with 5 to 7 ring members; R5 representing a hydrogen atom or a (C1-C3) alkyl group; R6 representing a hydrogen atom or a (C1-C4) alkyl group; R3 represents a hydrogen atom or a (C1-C6) alkyl group, or —OR3 represents a phosphate group; it being possible for the two groups R3 to form, together, an isopropylidene group; R4 represents a hydrogen atom or —OR4 represents a phosphate group; and the salts, solvates and isomers thereof. The invention also relates to a cosmetic composition comprising a compound (I) and the corresponding new compounds.
    Type: Application
    Filed: October 23, 2012
    Publication date: February 28, 2013
    Applicant: L'OREAL
    Inventor: L'OREAL
  • Publication number: 20130005632
    Abstract: An additive for lubricating oil of the present invention contains an amide compound represented by the following general formula (1). A lubricating oil composition of the present invention contains: a lubricating base oil containing a mineral base oil and/or a synthetic base oil; and an amide compound represented by the following general formula (1). R1R2N—COCH2OH??(1) (In the general formula (1), R1 and R2 may be the same or different and each represents an alkyl group having 16 to 22 carbon atoms.
    Type: Application
    Filed: March 15, 2011
    Publication date: January 3, 2013
    Applicant: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Osamu Kurosawa, Yasushi Onumata
  • Publication number: 20120302791
    Abstract: Novel ether-amide compounds are described. Uses of the compounds, in particular as solvents, for example in phytosanitary formulations are also described.
    Type: Application
    Filed: October 18, 2010
    Publication date: November 29, 2012
    Inventors: Thierry Vidal, Massimo Guglieri, Olivier Jentzer
  • Patent number: 8217200
    Abstract: According to the present invention, 2-chloroethoxy-acetic acid-N,N-dimethylamide of the Formula (I) is prepared by reacting 2-hydroxyethoxy-acetic acid-N,N-dimethylamide of the Formula (II) in a solvent optionally in the presence of a catalyst with thionyl chloride and removing the solvent by distillation.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: July 10, 2012
    Assignee: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Péter Trinka, Tibor Mezei, József Reiter, Ferenc Bartha, Zoltán Katona, Györgyi Vereczkeyné Donáth, Kálmán Nagy, László Pongó
  • Publication number: 20120004183
    Abstract: This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
    Type: Application
    Filed: June 23, 2011
    Publication date: January 5, 2012
    Applicant: The Scripps Research Institute
    Inventors: Alexander Deiters, T. Ashton Cropp, Jason W. Chin, J. Christopher Anderson, Peter G. Schultz
  • Publication number: 20110313147
    Abstract: Ion exchange and hydrophobic interaction chromatographic materials are constructed by tethering a terminal binding functionality to a solid support via a hydrophobic linker. The backbone of the linker typically comprises sulfur-containing moieties. Suitable terminal binding functionalities are tertiary amines, quaternary ammonium salts, or hydrophobic groups. These chromatographic materials possess both hydrophobic and ionic character under the conditions prescribed for their use. The separation of proteins from crude mixtures at physiological ionic strength can be accomplished with a chromatographic material of this type by applying pH or ionic strength gradients, thereby effecting protein adsorption and desorption.
    Type: Application
    Filed: August 16, 2011
    Publication date: December 22, 2011
    Applicant: PALL CORPORATION
    Inventors: Egisto Boschetti, Pierre Girot
  • Publication number: 20110292141
    Abstract: A nonaqueous ink composition for ink jet recording includes a solvent represented by general formula (1) and having a hydrophile-lipophile balance value of 10.5 to 20.0: where R1 denotes an alkyl group having 1 to 4 carbon atoms.
    Type: Application
    Filed: May 26, 2011
    Publication date: December 1, 2011
    Applicant: Seiko Epson Corporation
    Inventors: Akihito Sao, Shinichi Itaya, Shushi Makita
  • Publication number: 20110263898
    Abstract: Novel ether-amide compounds having the formula RaRbC(OR1)—CHRc—CONR2R3 and processes for the preparation and use thereof, especially as solvents, for example in phytosanitary formulations.
    Type: Application
    Filed: April 30, 2009
    Publication date: October 27, 2011
    Applicant: RHODIA OPERATIONS
    Inventors: Massimo Guglieri, Olivier Jentzer
  • Publication number: 20110237765
    Abstract: A perfluoropolyether thiol compound comprises a perfluoropolyether segment, at least one mercapto group (—SH), and at least one intervening divalent carbonylimino moiety (—C(?O)—NR—, wherein R is hydrogen or alkyl). The compound can be produced, for example, by a ring-opening reaction of thiolactones with perfluoropolyether-substituted, primary or secondary amines. The compound can be used, for example, as a polymerization chain transfer agent, as an intermediate for the preparation of functional group-containing fluorochemical derivatives such as disulfides, and as a fluorinated surface treatment.
    Type: Application
    Filed: December 2, 2009
    Publication date: September 29, 2011
    Inventors: Suresh S. Iyer, Mark J. Pellerite, Chetan P. Jariwala
  • Publication number: 20110136902
    Abstract: There provided a 12-membered-ring macrolactam derivative having antitumor activity: A compound represented by Formula (1) or a salt thereof. In this Formula, R1 is a hydrogen atom, a C1-6 alkyl group, a C1-6 alkylcarbonyl group or a C6-14 arylcarbonyl group; R2 is a hydrogen atom or a C1-6 alkyl group; R3 is a hydrogen atom or a hydroxyl group; R4 is a hydrogen atom or a hydroxyl group; R5 is a hydrogen atom or a C1-6 alkyl group; R6 is a hydrogen atom or a hydroxyl group; and R7 is an acetyl group or the like.
    Type: Application
    Filed: February 15, 2011
    Publication date: June 9, 2011
    Inventors: Masayuki MIYANO, Daisuke ITO, Norio MURAI
  • Publication number: 20100256412
    Abstract: Provided are fluorinated polyethers and polyether oils and methods of preparation. The preparation involves a catalytic oxidation process of fluorinated vinyl ethers employing free oxygen.
    Type: Application
    Filed: August 26, 2008
    Publication date: October 7, 2010
    Inventors: Werner Schwertfeger, Klaus Hintzer, Harald Kaspar, Egon Obermaier
  • Publication number: 20100063135
    Abstract: Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.
    Type: Application
    Filed: September 10, 2009
    Publication date: March 11, 2010
    Applicant: ABBOTT LABORATORIES
    Inventors: Prasad A. Dande, Todd M. Hansen, Robert D. Hubbard, William E. Kohlbrenner, Leiming Li, Aparna V. Sarthy, Yu Shen, Lu Tian, Carol K. Wada, Xiaobin Zhao
  • Publication number: 20090325246
    Abstract: According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield. The present invention also relates to a process for preparing a betaine represented by formula (1) below, comprising a step of quaternary aminating an amide represented by formula (2) below: wherein A1, A2 and A3 individually represent a C1-C20 hydrocarbon group which may have a substituent(s); and X1 is a halogen atom.
    Type: Application
    Filed: November 9, 2007
    Publication date: December 31, 2009
    Applicant: MITSUBISHI RAYON CO., LTD.
    Inventors: Kosuke Oishi, Eiji Sato, Hiroyuki Mori, Akira Yoshioka
  • Patent number: 7638650
    Abstract: A compound of formula (I): wherein k is 1 or 2; Y is —CH2CH(CF3)2 or —(CH2)nCF; X is hydrogen, —(CH2)nRf, or —C(O)[CF(A)]p-B—Rf, wherein B is a covalent bond, —O— or —(CH2)m—; A is —F or —CF3; and each Rf is independently C1 to C6 perfluorinated alkyl, optionally interrupted by one or more oxygens; Ro is Ro1 or is an alkyl having from about 10 to about 100 carbon atoms, interrupted or substituted by one or more hydrophilic groups; R is hydrogen or a C1 to C4 alkyl; and Ro1 is an aliphatic group of from about 10 to about 100 carbon atoms, interrupted by about from about 5 to about 50 ether oxygens; provided that 1) when Y is —(CH2)nRf, Ro is Ro1; 2) when X is hydrogen, Y is —CH2CH(CF3)2; and 3) when X is —(CH2)nRf and Y is —(CH2)nRf, Ro is Ro1.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: December 29, 2009
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Weiming Qiu
  • Publication number: 20090227453
    Abstract: This invention relates to the use of lactamide compounds of formula (I): CH3CH(OH)C(?O)NR1R2, where R1 and R2 are each independently hydrogen; or C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl, each of which is optionally substituted by up to three substituents independently selected from phenyl, hydroxy, C1-5 alkoxy, morpholinyl and NR3R4 where R3 and R4 are each independently C1-3 alkyl; or phenyl optionally substituted by up to three substituents independently selected from C1-3 alkyl; or R1 and R2 together with the nitrogen atom to which they are attached form a morpholinyl, pyrrolidinyl, piperidinyl or azepanyl ring, each of which is optionally substituted by up to three substituents independently selected from C1-3 alkyl, in formulations to reduce the toxicity associated with other formulation components; to the use of certain lactamide compounds as solvents, especially in formulations, particularly in agrochemical formulations and in environmentally friendly formulations; to novel lactamide compounds; and
    Type: Application
    Filed: March 21, 2007
    Publication date: September 10, 2009
    Applicant: SYNGENTA LIMITED
    Inventors: Gordon Alastair Bell, Ian David Tovey
  • Publication number: 20090221853
    Abstract: According to the present invention, 2-chloroethoxy-acetic acid-N,N-dimethylamide of the Formula (I) is prepared by reacting 2-hydroxyethoxy-acetic acid-N,N-dimethylamide of the Formula (II) in a solvent optionally in the presence of a catalyst with thionyl chloride and removing the solvent by distillation.
    Type: Application
    Filed: December 8, 2006
    Publication date: September 3, 2009
    Inventors: Peter Trinka, Tibor Mezei, Jozsef Reiter, Ferenc Bartha, Zoltan Katona, Gyorgyi Vereczkeynedonath, Kalman Nagy, Laszlo Pongo
  • Patent number: 7323609
    Abstract: The invention provides the use of compounds of the formula (1) where R1, R2 are each independently C1- to C22-alkyl, C2- to C22-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, R3 is C1- to C22-alkyl, C2- to C22-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, —CHR6COO? or —O?, A is a C2- to C4-alkylene group, B is a C1- to C10-alkylene group, X is O or NR7 R6, R7 are each independently hydrogen, C1- to C22-alkyl, C2- to C22-alkenyl, C6- to C30-aryl or C7- to C30-alkylaryl, R4 is a C1- to C50-alkyl, C2- to C50-alkenyl radical, C6- to C50-aryl or C7- to C50-alkylaryl, R5 is hydrogen, —OH or a C1- to C4-alkyl radical, n, m are each independently a number from 0 to 30, x is a number from 1 to 6, as corrosion and gas hydrate inhibitors, and also the compounds of formula 1.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: January 29, 2008
    Assignee: Clariant Produkte (Deutschland) GmbH
    Inventors: Uwe Dahlmann, Michael Feustel
  • Publication number: 20070232806
    Abstract: Hydride process for making acyclic diol intermediates from cyclic intermediates, useful in antibacterial quinolone synthesis.
    Type: Application
    Filed: March 26, 2007
    Publication date: October 4, 2007
    Applicant: The Procter & Gamble Company
    Inventors: Michael Patrick Hayes, Tammy Talbot Schunk
  • Patent number: 7138546
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: November 21, 2006
    Assignee: Emisphere Technologies, Inc.
    Inventor: Pingwah Tang
  • Patent number: 6812368
    Abstract: The invention relates to a novel process of diastereoselective hydrogenation of 1,3-hydroxyketones of formula (I) wherein R, R′ and R″ are as defined in claim 1 which is carried out in a solvent in the presence of a magnesium salt, a heterogeneous platinum catalyst and optionally an oxidant.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: November 2, 2004
    Assignee: Solvias AG
    Inventors: Martin Studer, Stephan Burkhardt, Ulrike Nettekoven
  • Patent number: 6770679
    Abstract: The present invention relates to nonionic compounds of the polyoxymethylene type that are low-foaming and can be used as surfactants, especially in cleaning compositions at an alkaline pH. They are obtained from unsaturated nitriles, that have been epoxidized with e.g. hydrogen perroxide, and alkyl blocked polyalkylene glycols. The nonionic nitrile surfactants can be reacted further with e.g. hydrogen peroxide under alkaline conditions to obtain nonionic amide surfactants. Amide derivatives of this type could also be obtained by reaction between ammonia or a primary or secondary amine and an acid or ester. The nonionic compounds exhibit one or several structure elements according to formula (II) in the aliphatic carbon chain where AO is an alkyleneoxy group containing 2-4 carbon atom, R3 is an alkyl group with 1-4 carbon atoms and n is a number between 1 and 30.
    Type: Grant
    Filed: March 4, 2002
    Date of Patent: August 3, 2004
    Assignee: Akzo Nobel N.V
    Inventor: Elina Sandberg
  • Patent number: 6689910
    Abstract: Olefins containing selected functional groups such as silyl, ether and alkenyl, and often containing a blocking group, may be copolymerized with unsubstituted olefins such as ethylene and propylene in the presence of certain coordination compounds of nickel or palladium. The resulting polymers are useful as molding resins, elastomers, in adhesives and for films.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: February 10, 2004
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Lin Wang, Samuel David Arthur, Elizabeth Forrester McCord, Yueli Wang, Peter Arnold Morken, Lynda Kaye Johnson
  • Publication number: 20040010154
    Abstract: The invention relates to a novel process of diastereoselective hydrogenation of 1,3-hydroxyketones of formula (I) 1
    Type: Application
    Filed: July 2, 2003
    Publication date: January 15, 2004
    Inventors: Martin Studer, Stephan Burkhardt, Ulrike Nettekoven
  • Publication number: 20030216287
    Abstract: Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
    Type: Application
    Filed: May 7, 2003
    Publication date: November 20, 2003
    Inventor: Pingwah Tang
  • Patent number: 6562995
    Abstract: Amidomethyl esters, carbonylmercaptomethyl esters, keto-containing esters, amidomethyl thioesters, amidomethyl amides, and methylene dithioesters are disclosed. The novel compounds have two carbonyl groups connected by a linking moiety having an oxygen, sulfur or nitrogen attached to a methylene group, to which is further attached a sulfur, nitrogen or CH2 group. Methods of treating illnesses and conditions, such as cancer, hemological disorders, inherited metabolic disorders and others, using these compounds are also disclosed.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: May 13, 2003
    Assignee: Beacon Laboratories, Inc.
    Inventors: Hsuan-Yin Lan-Hargest, Norbert L. Wiech
  • Publication number: 20030065035
    Abstract: A Type IV crystal of (Z)-N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide hydrochloride, which can be produced by crystallization using a solvent containing water at 2% by weight at the maximum and which has a X ray powder diffraction pattern containing peaks at least at 13.4°, 18.7°, 19.4°, and 22.5° (2&thgr;), is provided. This compound is useful as an effective ingredient for a carcinostatic agent. The crystal of the present invention has excellent properties desirable from the standpoint of the production of medicinal products, i.e., reduced water adsorption and extremely high stability to water. Also provided are a method for producing the Type IV crystal thereof and a method for use of the crystal.
    Type: Application
    Filed: September 16, 2002
    Publication date: April 3, 2003
    Applicant: AJINOMOTO CO. INC
    Inventors: Shinichiro Takahashi, Yoko Sugawara, Hiroyuki Matsueda
  • Patent number: 6492545
    Abstract: A novel process in which an optically active alcohol compound having a desired absolute configuration and a high optical purity can be obtained by asymmetrically hydrogenating a &bgr;-keto acid compound through a simple operation. An optically active alcohol represented by general formula (III) as defined is obtained by asymmetrically hydrogenating a &bgr;-keto ester compound represented by general formula (I) as defined in the presence of at least one ruthenium complex having as a ligand an optically active tertiary diphosphine compound represented by general formula (II) as defined.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: December 10, 2002
    Assignee: Takasago International Corporation
    Inventors: Takao Saito, Tohru Yokozawa, Kazuhiko Matsumura, Noboru Sayo
  • Patent number: 6423748
    Abstract: Amido polybiguanides and their use as antimicrobial agents in pharmaceutical compositions are disclosed. A method of synthesis of amido polybiguanides is also disclosed. The amido polybiguanides are useful in the preservation of pharmaceutical compositions, particulary opthalmic and otic pharmaceutical compositions and compositions for treating contact lenses. The compounds are especially useful for disinfecting contact lenses.
    Type: Grant
    Filed: September 19, 2000
    Date of Patent: July 23, 2002
    Assignee: Alcon Manufacturing, Ltd.
    Inventors: Joonsup Park, Nathaniel D. McQueen
  • Publication number: 20020086902
    Abstract: The present invention provides an improved process for the preparation of N-(substituted phenyl)-3-alkyl-, aryl- and heteroarylsulfonyl-2-hydroxy-2-alkyl- and haloalkylpropanamide compounds of formula I 1
    Type: Application
    Filed: September 17, 2001
    Publication date: July 4, 2002
    Inventors: Bang-Chi Chen, Joseph E. Sundeen, Rulin Zhao
  • Publication number: 20020049352
    Abstract: The present invention relates to a scaleable process for the oxidation of carbon-boron bonds with Oxone®.
    Type: Application
    Filed: June 25, 2001
    Publication date: April 25, 2002
    Inventors: Weiling Cai, David H. Ripin
  • Patent number: 6372918
    Abstract: The invention relates to compounds of the formula 1 R1—O—(A—O)x—(CH2)y—R2  (1) in which R1 is branched or straight-chain C4-C30-alkyl, C4-C30-alkenyl or C4-C30-alkylaryl, A is C2-C4-alkylene, x is an integer from 1 to 100, y is 1, 2, 3 or 4 and R2 is a radical selected from structures of the formulae 2 and 3 —CO—NR3R4  (2) in which one of the radicals R3 and R4 is a hydrocarbon chain which has at least one free NH or NH2 group and the other radical is hydrogen or a hydrocarbon chain which has at least one free NH or NH2 group and R5 is hydrogen or a hydrocarbon chain which has at least one free NH or NH2 group.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: April 16, 2002
    Assignee: Clariant GmbH
    Inventors: Michael Feustel, Peter Klug
  • Patent number: 6353012
    Abstract: HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: March 5, 2002
    Assignee: Alcon Universal Ltd.
    Inventors: Mark R. Hellberg, John M. Yanni, Gustav Graff, Daniel A. Gamache, Peter G. Klimko
  • Publication number: 20020016506
    Abstract: A process of reacting a nitroaniline compound of formula (2); 1
    Type: Application
    Filed: July 12, 2001
    Publication date: February 7, 2002
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Tomoyasu Yoshida
  • Patent number: 6312481
    Abstract: Monoamide-containing polyether alcohol compounds of the formula: wherein R1, R2 and R3 are each independently selected from hydrogen, hydrocarbyl of 1 to 100 carbon atoms, substituted hydrocarbyl of 1 to 100 carbon atoms and polyoxyalkylene alcohol of 2 to 200 carbon atoms or R2 and R3 taken together form a heterocyclic group of 2 to 100 carbon atoms or a substituted heterocyclic group of 2 to 100 carbon atoms with the proviso that at least one of R1, R2 or R3 must be polyoxyalkylene alcohol have been found to decrease intake valve deposits, control octane requirement increases and reduce octane requirement when used as gasoline additives.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: November 6, 2001
    Assignee: Shell Oil Company
    Inventors: Jiang-Jen Lin, James R. Macias, Sarah Louise Weaver
  • Patent number: 6306463
    Abstract: This invention provides water-based compositions which are essentially free of hydrocarbon solvents, particularly coating, ink, fountain solution, adhesive, agricultural and electronics cleaning compositions, manifesting reduced equilibrium and dynamic surface tension by the incorporation of a surface tension reducing amount of certain tri-alkylamides of citric acid of the structure where R1, R2 and R3 are independently C1 to C18 alkyl groups.
    Type: Grant
    Filed: July 20, 2000
    Date of Patent: October 23, 2001
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Caroline Sassano Slone, Kevin Rodney Lassila, Ingrid Kristine Meier
  • Patent number: 6255343
    Abstract: 2,2-Difluoro HETE derivatives and methods of their use for treating dry eye are disclosed.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: July 3, 2001
    Assignee: Alcon Universal Ltd.
    Inventor: David B. Belanger
  • Patent number: 6235933
    Abstract: The invention relates to a process for preparing a &bgr;-hydroxyalkylamide, in which alkyl esters are reacted with &bgr;-aminoalcohols in the absence of solvents and in the presence of basic catalysts, where, to improve the selectivity, the ratio of equivalents of ester to equivalents of amine is 1:1.001 to 8.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: May 22, 2001
    Assignee: EMS-Chemie AG
    Inventors: Andreas Kaplan, Rene Gisler, Albert Reich
  • Patent number: RE38506
    Abstract: The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1=R3—N—R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells.
    Type: Grant
    Filed: November 2, 2001
    Date of Patent: April 20, 2004
    Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia University in the City of New York
    Inventors: Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic