Benzene Ring In A Substituent E Patents (Class 564/207)
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Patent number: 10851045Abstract: Acrylamide photoinitiators are provided, in which a photoinitiator moiety and an acrylamide are incorporated into the photoinitiator structure.Type: GrantFiled: March 22, 2018Date of Patent: December 1, 2020Assignee: Coloplast A/SInventors: Jakob Vange, Petr Sehnal, David Jepson, Andrew Towns
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Patent number: 10786481Abstract: Disclosed are hydroquinone compounds, preparation methods therefor, and uses thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compounds are shown by formula I, wherein X is C?O or CH2; Y is NH, O or absent; R is a substituted or unsubstituted alkyl group having at least one carbon atom, a substituted or unsubstituted cycloalkyl group having at least three carbon atoms, a substituted or unsubstituted alkenyl group or alkynyl group having at least two carbon atoms; and a substituted or unsubstituted aryl group or heteroaryl group containing at least four carbon atoms. The compounds provided slowly release 2-tert-butyl-4-methoxyphenol in vivo and maintain stable plasma concentration of 2-tert-butyl-4-methoxyphenol (T½=12˜24 h). The compounds provided by the present invention protect the phenolic hydroxyl group of 2-tert-butyl-4-methoxyphenol, avoid environmental oxidation and increase the environmental stability of drugs containing the compounds.Type: GrantFiled: February 22, 2017Date of Patent: September 29, 2020Assignees: BIOMEDICAL ANAYLSIS CENTER, ACADEMY OF MILITARY MEDICAL SCIENCES, INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCESInventors: Xuemin Zhang, Xinhua He, Tao Zhou, Zhenggang Liu, Tao Li
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Publication number: 20150119423Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of local pain may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of moderate to severe pain, neuropathic pain, post herpetic neuralgia and rheumatic pains.Type: ApplicationFiled: May 18, 2013Publication date: April 30, 2015Inventor: Mahesh Kandula
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Publication number: 20150084031Abstract: A polymerizable monomer represented by the following formula (1) wherein at least one of Ar1 to Ar3 is substituted by a group represented by the following formula (2) and which is substituted by one or more groups comprising a polymerizable functional group. Ar1 to Ar3 are a substituted or unsubstituted aryl group having 6 to 40 ring carbon atoms, Ar6 is a substituted or unsubstituted aryl group having 6 to 40 ring carbon atoms and Ar4 and Ar5 are a substituted or unsubstituted arylene group having 6 to 40 ring carbon atoms.Type: ApplicationFiled: December 2, 2014Publication date: March 26, 2015Inventors: Mitsuru EIDA, Nobohiro YABUNOUCHI, Yumiko MIZUKI, Masami WATANABE, Akinori YOMOGITA
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Publication number: 20140363634Abstract: Ink contains at least one of a compound represented by the following chemical formula 1, a compound represented by chemical formula 2, a compound represented by chemical formula 3, or a compound represented by chemical formula 4.Type: ApplicationFiled: May 27, 2014Publication date: December 11, 2014Inventors: Mitsunobu MORITA, Soh NOGUCHI, Okitoshi KIMURA
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Patent number: 8871976Abstract: The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells.Type: GrantFiled: August 26, 2011Date of Patent: October 28, 2014Assignees: National University of Singapore, Agency for Science, Technology and ResearchInventors: Young-Tae Chang, Sung Chan Lee, Nam Young Kang
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Publication number: 20140147481Abstract: The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents.Type: ApplicationFiled: June 3, 2011Publication date: May 29, 2014Applicants: UNIVERSITY OF RHODE ISLAND RESEARCH FOUNDATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: William Gerwick, Lena Gerwick, Huykjae Choi, Francisco Villa, Jennifer Smith, David C Rowley
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Patent number: 8722931Abstract: The invention is directed to a compound represented by the Formula (1) as defined herein, and a method for preparing a compound represented by the Formula (1) which includes: reacting a diamine compound represented by the Formula (2) as defined herein with a methacrylic anhydride or an acrylic anhydride under a condition where an organic acid having a pKa of 2.0 or more is present in an amount of 0.5 to 5.0 moles based on 1 mole of the diamine compound to obtain a reaction mixture; adding phosphoric acid to the reaction mixture; and purifying the reaction mixture by extraction with an organic solvent.Type: GrantFiled: December 21, 2011Date of Patent: May 13, 2014Assignee: FUJIFILM CorporationInventors: Yu Iwai, Takafumi Nakayama, Junya Abe, Ichiro Koyama
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Publication number: 20140094521Abstract: The objective of the present invention is to provide a new compound which is effective in treating blood cancer, particularly multiple myeloma, and which is also effective in suppressing an SP cell, i.e. Side Population Cell, which is a cause of recurrence of cancer. The compound according to the present invention is a novel compound which has the specific benzylamine structure.Type: ApplicationFiled: May 23, 2012Publication date: April 3, 2014Applicant: THE UNIVERSITY OF TOKUSHIMAInventors: Daisuke Tsuji, Kohji Itoh, Akira Otaka, Akira Shigenaga, Masahiro Abe, Masahiro Hiasa
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Publication number: 20140051751Abstract: Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize compounds having a Lipophilic-Amide-Spacer-ElectroNegative (“LASEN”) structural motif, such as capsaicin, and compounds having a TetraHydroCannibinoid (“THC”) structural motif. The antifoulant compositions are non-toxic, and effective.Type: ApplicationFiled: October 25, 2013Publication date: February 20, 2014Applicants: The Board of Regents of the University of Texas System, University of North Texas Health Science Center at Fort WorthInventors: John A. Schetz, Robert F. McMahon
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Patent number: 8575230Abstract: Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize compounds having a Lipophilic-Amide-Spacer-ElectroNegative (“LASEN”) structural motif, such as capsaicin, and compounds having a TetraHydroCannibinoid (“THC”) structural motif. The antifoulant compositions are non-toxic, and effective.Type: GrantFiled: April 16, 2008Date of Patent: November 5, 2013Assignees: University of North Texas Health Science Center at Fort Worth, The Board of Regents of the University of Texas SystemInventors: John A. Schetz, Robert F. McMahon
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Publication number: 20130267571Abstract: The present application provides a terpene analogue of Formula (I) or a pharmaceutically acceptable isomer, salt or ester thereof, and methods and uses thereof for treating neurological conditions such as pain in general and neuropathic pain. These terpene analogues can also be used to treat other electrical disorders in the central and peripheral nervous system. Also provided are methods of synthesizing the terpene analogues of Formula I.Type: ApplicationFiled: September 14, 2011Publication date: October 10, 2013Applicant: NeuroQuest Inc.Inventors: Mark A. Reed, Donald Weaver, Shengguo Sun, Alexander McLellan, Erhu Lu
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Publication number: 20130225409Abstract: Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amines, wherein the fatty amine is made by reducing the amide reaction product of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and a secondary amine, are disclosed. Quaternary ammonium, betaine, or sulfobetaine compositions derived from fatty amidoamines, wherein the amidoamine is made by reacting of a metathesis-derived C10-C17 monounsaturated acid, octadecene-1,18-dioic acid, or their ester derivatives and an aminoalkyl-substituted tertiary amine, are also disclosed. The quaternized compositions are advantageously sulfonated or sulfated. In one aspect, the ester derivative of the C10-C17 monoun-saturated acid or octadecene-1,18-dioic acid is a lower alkyl ester. In other aspects, the ester derivative is a modified triglyceride made by self-metathesis of a natural oil or an unsaturated triglyceride made by cross-metathesis of a natural oil with an olefin.Type: ApplicationFiled: October 25, 2011Publication date: August 29, 2013Applicant: Stepan CompanyInventors: Dave R. Allen, Marcos Alonso, Randal J. Bernhardt, Aaron Brown, Sangeeta Ganguly-Mink, Andrew D. Malec, Teresa Manuel, Ronald A. Masters, Lawrence A. Munie, Dennis S. Murphy, Patti Skelton, Brian Sook, Michael R. Terry, Jeremy Aaron Weitgenant, Laura Lee Whitlock, Michael Wiester, Patrick Shane Wolfe
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Publication number: 20130224790Abstract: The invention includes a compound represented by the following structural formula: wherein is described herein. The compounds of the invention are useful in staining embryonic stem cells.Type: ApplicationFiled: August 26, 2011Publication date: August 29, 2013Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPOREInventors: Young-Tae Chang, Sung Chan Lee, Nam Young Kang
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Publication number: 20130224318Abstract: The present invention describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine Palmitoyl Transferase-1 (CPT-1) modulators, optionally with other anti-lipid agents; and also describes compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.Type: ApplicationFiled: February 26, 2013Publication date: August 29, 2013Applicant: Avon Products, Inc.Inventor: Avon Products, Inc.
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Patent number: 8519138Abstract: A novel process for the preparation of the compound of formula (II): which process comprises reacting a compound of formula (VI): with a compound of formula (IV): in a suitable solvent.Type: GrantFiled: April 14, 2010Date of Patent: August 27, 2013Assignee: Glaxo Group LimitedInventors: Dean David Edney, Matthew Peter John
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Publication number: 20130023510Abstract: The present invention provides arachidonic acid (AA) analogs and compositions containing those analogs as active agents for use in analgesic treatments. Various methods of manufacturing the inventive compounds are provided and pharmaceutical formulations, including injectable and oral dosages, are described. Certain analogs are additionally useful as antipyretic compositions and in related fever reducing treatments.Type: ApplicationFiled: May 25, 2012Publication date: January 24, 2013Applicant: Cytometix, Inc.Inventors: Lane Brostrom, John R. Falck
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Publication number: 20130012592Abstract: The present invention relates to an agomelatine hydrobromide hydrate of formula I wherein X is Br, preparation and use thereof, and to pharmaceutical compositions containing it. The agomelatine hydrobromide hydrate obtained through the present method has significant increased solubility than agomelatine, and therefore is more suitable for manufacturing pharmaceutical formulations. In addition, the product enjoys higher stability and purity. Using the present method, product of high purity can be obtained through a simple process, free of any complicated steps.Type: ApplicationFiled: March 17, 2011Publication date: January 10, 2013Applicant: Les Laboratoires ServierInventors: Hanbin Shan, Zhedong Yuan, Xueyan Zhu, Peng Zhang, Hongjuan Pan, Xiong Yu
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Patent number: 8236987Abstract: The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.Type: GrantFiled: November 9, 2007Date of Patent: August 7, 2012Assignees: The Regents of the University of California, Oregon Health & Science UniversityInventors: Thomas S. Scanlan, Toru Iijima
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Patent number: 8227254Abstract: The present invention pertains to compounds and polymers which incorporate a boronic acid sensor group (SG) of the formula (I): wherein: J is independently —CH2— or —CH2CH2—; n is independently 0, 1, 2, or 3; and each RR, if present, is independently a ring substituent; and wherein the ring attachment (i.e., where sensor group is attached) is via the 3-, 4-, 5-, or 6-ring position. Such compounds and polymers are useful in the selective chemical detection and/or quantitation of alpha-hydroxy carboxylic acids, such as lactic acid/lactate and malic acid/malate. The present invention also pertains to methods of preparing such compounds and polymers; methods and assays which employ these compounds and polymers; devices (e.g., holographic sensors) and kits for use in such methods and assays, etc.Type: GrantFiled: January 31, 2006Date of Patent: July 24, 2012Assignee: Cambridge Enterprise LimitedInventors: Christopher Robin Lowe, Felicity Kate Sartain, Xiaoping Yang
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Publication number: 20120165572Abstract: The invention is directed to a compound represented by the Formula (1) as defined herein, and a method for preparing a compound represented by the Formula (1) which includes: reacting a diamine compound represented by the Formula (2) as defined herein with a methacrylic anhydride or an acrylic anhydride under a condition where an organic acid having a pKa of 2.0 or more is present in an amount of 0.5 to 5.0 moles based on 1 mole of the diamine compound to obtain a reaction mixture; adding phosphoric acid to the reaction mixture; and purifying the reaction mixture by extraction with an organic solvent.Type: ApplicationFiled: December 21, 2011Publication date: June 28, 2012Applicant: FUJIFILM CORPORATIONInventors: Yu IWAI, Takafumi NAKAYAMA, Junya ABE, Ichiro KOYAMA
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Publication number: 20120046469Abstract: A novel process for the preparation of the compound of formula (II): which process comprises reacting a compound of formula (VI): with a compound of formula (IV): in a suitable solvent.Type: ApplicationFiled: April 14, 2010Publication date: February 23, 2012Applicant: GLAXO GROUP LIMITEDInventors: Dean David Edney, Matthew Peter John
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Publication number: 20120018710Abstract: A polymerizable monomer represented by the following formula (1) which is substituted by one or more groups comprising a polymerizable functional group wherein Ar1 and Ar4 to Ar6 are independently a substituted or unsubstituted aryl group having 6 to 40 ring carbon atoms; and Ar2, Ar3 and L1 are a substituted or unsubstituted arylene group having 6 to 40 ring carbon atoms:Type: ApplicationFiled: February 9, 2010Publication date: January 26, 2012Inventors: Mitsuru Eida, Masami Watanabe, Masahiko Fukuda, Nobuhiro Yabunouchi
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Publication number: 20110315964Abstract: A polymerizable monomer represented by the following formula (1) wherein at least one of Ar1 to Ar3 is substituted by a group represented by the following formula (2) and which is substituted by one or more groups comprising a polymerizable functional group. Ar1 to Ar3 are a substituted or unsubstituted aryl group having 6 to 40 ring carbon atoms, Ar6 is a substituted or unsubstituted aryl group having 6 to 40 ring carbon atoms and Ar4 and Ar5 are a substituted or unsubstituted arylene group having 6 to 40 ring carbon atoms.Type: ApplicationFiled: March 5, 2010Publication date: December 29, 2011Inventors: Mitsuru Eida, Nobuhiro Yabunouchi, Yumiko Mizuki, Masami Watanabe, Akinori Yomogita
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Patent number: 7939241Abstract: The present invention relates to a novel (meth)acrylamide compound represented by the general formula (1), a (co)polymer of the (meth)acrylamide compound, and a chemically amplified photosensitive resin composition composed of the polymer and a photoacid generator. In the formula, R1 represents a hydrogen atom or a methyl group; R2 represents an acid-decomposable group; and R3 to R6 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 4 carbon atoms.Type: GrantFiled: May 12, 2006Date of Patent: May 10, 2011Assignee: NEC CorporationInventors: Katsumi Maeda, Kaichirou Nakano
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Patent number: 7932303Abstract: A material contains at least a polymerizable N,O-functionalized acrylic acid hydroxyamide of the Formula (I) in which A is an n+m-valent linear or branched aliphatic C1 to C50 radical, in which the carbon chain can be interrupted by O, S, —CO—O—, CO—NH, O—CO—NH or NH—CO—NH, an n+m-valent aromatic C6 to C18 radical or an n+m-valent cycloaliphatic or heterocyclic C3 to C18 radical, wherein the radicals can carry one or more substituents, Y is not present, or is O, S, an ester, amide or urethane group, R1 is hydrogen, an aliphatic C1 to C20 alkyl or C3 to C8 cycloalkyl radical which can carry one or more substituents, R2 is H or a C1 to C10 alkyl radical, R3 is not present or is a C1 to C16 alkylene radical which can be interrupted by O, HG is not present, is —COOH, —P?O(OH)2; —P?O(OH)(OR4); —O—P?O(OH)2, —SO2OH or —O—P?O(OH)(OR4), R4 is a C1 to C15 alkyl radical, phenyl or benzyl radical and n is a number from 1 to 5 and m a number from 0 to 3.Type: GrantFiled: September 11, 2007Date of Patent: April 26, 2011Assignee: Ivoclar Vivadent AGInventors: Norbert Moszner, Iris Lamparth, Urs Karl Fischer, Frank Zeuner, Armin de Meijere, Volker M. Rheinberger
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Patent number: 7928134Abstract: The invention is directed to 5-(hetero)aryl-4,5-dihydro-(1H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor agonists, to pharmaceutical compositions comprising these compounds, to methods for their syntheses, methods for preparing novel intermediates useful for their syntheses, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, administered to patients to achieve a therapeutic effect in disorders in which CB1 receptors are involved, or that can be treated via manipulation of those receptors. Compounds of the present invention include compounds of formula (I): wherein the substituents have the definitions given in the specification.Type: GrantFiled: September 19, 2008Date of Patent: April 19, 2011Assignee: Solvay Pharmaceuticals B.V.Inventors: Josephus H. M. Lange, Hicham Zilaout, Bernard J. Van Vliet
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Publication number: 20100256256Abstract: Environmentally-friendly alternatives to organometallic antifoulants that are efficacious at preventing biofouling by organisms such as the zebra mussel. Preferred antifoulant compositions utilize compounds having a Lipophilic-Amide-Spacer-ElectroNegative (“LASEN”) structural motif, such as capsaicin, and compounds having a TetraHydroCannibinoid (“THC”) structural motif. The antifoulant compositions are non-toxic, and effective.Type: ApplicationFiled: April 16, 2008Publication date: October 7, 2010Inventors: John A. Schetz, Robert F. McMahon
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Publication number: 20100048723Abstract: Compositions useful to prevent or treat obesity in an animal are disclosed. The compositions comprise a capsaicinoid, preferably capsaicin, or an active metabolite thereof, in an amount effect to prevent or treat obesity in an animal. Also disclosed are methods to prevent or treat obesity in an animal comprising administering a composition of the present invention.Type: ApplicationFiled: February 23, 2007Publication date: February 25, 2010Inventors: Ryan Michael Yamka, Kim Gene Friesen
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Publication number: 20090105437Abstract: The present invention provides pressure-sensitive adhesives having a refractive index of at least 1.50. The pressure-sensitive adhesives comprise at least one monomer containing a substituted or an unsubstituted biphenyl group.Type: ApplicationFiled: October 19, 2007Publication date: April 23, 2009Inventors: Michael D. Determan, Albert I. Everaerts, Cheryl L. Moore, David B. Olson
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Publication number: 20090068587Abstract: The present invention relates to a novel (meth)acrylamide compound represented by the general formula (1), a (co)polymer of the (meth)acrylamide compound, and a chemically amplified photosensitive resin composition composed of the polymer and a photoacid generator. In the formula, R1 represents a hydrogen atom or a methyl group; R2 represents an acid-decomposable group; and R3 to R6 independently represent a hydrogen atom, a halogen atom or an alkyl group having 1 to 4 carbon atoms.Type: ApplicationFiled: May 12, 2006Publication date: March 12, 2009Applicant: NEC CorporationInventors: Katsumi Maeda, Kaichirou Nakano
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Publication number: 20080269324Abstract: A drag may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inhibits, antagonizes, or short-circuits the visual cycle at a step of the visual cycle that occurs outside a disc of a rod photoreceptor cell.Type: ApplicationFiled: August 7, 2006Publication date: October 30, 2008Inventor: Robert R. Rando
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Publication number: 20080234405Abstract: A material contains at least a polymerizable N,O-functionalized acrylic acid hydroxyamide of the Formula (I) in which A is an n+m-valent linear or branched aliphatic C1 to C50 radical, in which the carbon chain can be interrupted by O, S, —CO—O—, CO—NH, O—CO—NH or NH—CO—NH, an n+m-valent aromatic C6 to C18 radical or an n+m-valent cycloaliphatic or heterocyclic C3 to C18 radical, wherein the radicals can carry one or more substituents, Y is not present, or is O, S, an ester, amide or urethane group, R1 is hydrogen, an aliphatic C1 to C20 alkyl or C3 to C8 cycloalkyl radical which can carry one or more substituents, R2 is H or a C1 to C10 alkyl radical, R3 is not present or is a C1 to C16 alkylene radical which can be interrupted by O, HG is not present, is —COOH, —P?O(OH)2; —P?O(OH)(OR4); —O—P?O(OH)2, —SO2OH or —O—P?O(OH)(OR4), R4 is a C1 to C15 alkyl radical, phenyl or benzyl radical and n is a number from 1 to 5 and m a number from 0 to 3.Type: ApplicationFiled: September 11, 2007Publication date: September 25, 2008Applicant: Ivoclar Vivadent AGInventors: Norbert Moszner, Iris Lamparth, Urs Karl Fischer, Frank Zeuner, Armin de Meijere, Volker M. Rheinberger
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Publication number: 20080160225Abstract: The present invention pertains to compounds and polymers which incorporate a boronic acid sensor group (SG) of the formula (I): wherein: J is independently —CH2— or —CH2CH2—; n is independently 0, 1, 2, or 3; and each RR, if present, is independently a ring substituent; and wherein the ring attachment (i.e., where sensor group is attached) is via the 3-, 4-, 5-, or 6-ring position. Such compounds and polymers are useful in the selective chemical detection and/or quantitation of alpha-hydroxy carboxylic acids, such as lactic acid/lactate and malic acid/malate. The present invention also pertains to methods of preparing such compounds and polymers; methods and assays which employ these compounds and polymers; devices (e.g., holographic sensors) and kits for use in such methods and assays, etc.Type: ApplicationFiled: January 31, 2006Publication date: July 3, 2008Applicant: CAMBRIDGE ENTERPRISE LIMITEDInventors: Christopher Robin Lowe, Felicity Kate Sartain, Xiaoping Yang
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Patent number: 7196119Abstract: The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclosed, including pharmaceutical formulations of the disclosed novel compounds in useful compositions.Type: GrantFiled: October 20, 2004Date of Patent: March 27, 2007Assignees: The Regents of the University of California, Oregon Health & Science UniversityInventors: Thomas S. Scanlan, Martin J. Kelly, Jian Qiu, Sandra Tobias, Oline K. Ronnekleiv
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Patent number: 6852888Abstract: There are described compounds of formula in free form or in salt form, a process for the preparation of such compounds and the use of such compounds, pesticidal compositions in which the active ingredient is selected from those compounds, in free form or in an agrochemically suitable salt form, a method of preparing such compositions and the use of such compositions, plant propagation material treated with such compositions, and a method of controlling pests.Type: GrantFiled: December 2, 2000Date of Patent: February 8, 2005Assignee: Syngenta Crop Protection, Inc.Inventors: Franziska Boeger, Peter Maienfisch, Thomas Pitterna, Christian Martin Boeger, Oliver Wolfang Boeger, Manfred Boeger
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Patent number: 6683211Abstract: The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is halogen, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkenylthio; optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenylsulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonType: GrantFiled: November 15, 2002Date of Patent: January 27, 2004Assignee: Syngenta Crop Protection, Inc.Inventors: Clemens Lamberth, Martin Zeller, Walter Kunz, Fredrik Cederbaum
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Patent number: 6646137Abstract: Non-peptide GnRH agents capable of inhibiting the effect of gonadotropin-releasing hormone are of the following general formula, where X1, X2, Y, and Z are defined variables: Such compounds and their pharmaceutically acceptable salts, multimers, prodrugs, and active metabolites are suitable for treating mammalian reproductive disorders and steroid hormone-dependent tumors as well as for regulating fertility, where suppression of gonadotropin release is indicated. Methods for synthesizing the compounds and intermediates useful in their preparation are also described.Type: GrantFiled: November 22, 2000Date of Patent: November 11, 2003Inventors: Mark Brian Anderson, Alexander Polinsky, Yufeng Hong, Vlad Edward Gregor
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Patent number: 6562963Abstract: The present invention is directed to a process for the preparation of a compound of formula (X-a) or a pharmaceutically acceptable salt form thereof, wherein: R1 is selected from the group consisting of: C1-5 alkyl substituted with 0-5 R1a, —(CH2)r—C3-10 cycloalkyl substituted with 0-5 R1a, and —(CH2)r-aryl substituted with 0-5 R1a. Compounds of Formula (X-a) are macrocyclic molecules containing anti-succinate residues which inhibit metalloproteinases such as aggrecanase, and the production of tumor necrosis factor (TNF). The anti-succinates are formed by an Ireland Claisen rearrangement of a silyl ketene acetal which proceeds with high stereoselectivity.Type: GrantFiled: July 31, 2001Date of Patent: May 13, 2003Inventors: Roberta L. Dorow, Silvio Campagna, Pasquale N. Confalone, Fuqiang Jin, Zhe Wang
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Patent number: 6423870Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m′ are such as defined in the description; n represents an integer such that 0≦n≦3; p represents an integer such as defined in the description; B represents a group (a) or (b). The invention is useful for preparing medicines.Type: GrantFiled: July 14, 2000Date of Patent: July 23, 2002Assignee: Les Laboratoires ServierInventors: Michel Langlois, Monique Mathe-Allainmat, Carole Jellimann, Jean Andrieux, Caroline Bennejean, Pierre Renard, Philippe Delagrange
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Patent number: 6388085Abstract: Polyacetylene compounds and process for the preparation thereof from a chiral dihydroxy amide are described. The compounds preferably have diacyl groups attached to the amide. The compounds are useful for making films which are electrically conductive, near infrared absorbing, polarizing, and have the characteristic optical and other properties of polyacetylenes.Type: GrantFiled: August 23, 2000Date of Patent: May 14, 2002Assignee: Board of Trustees of Michigan State UniversityInventors: Rawle I. Hollingsworth, Guijun Wang
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Patent number: 6214869Abstract: There is provided a novel series of cis cyclopropane compounds of Formula I wherein R1, R2, R3, R4, X, Y, Z and m are as defined herein which bind to the human melatonin receptor and therefore are useful as melatonergic agents.Type: GrantFiled: May 25, 1999Date of Patent: April 10, 2001Assignee: Bristol-Myers SquibbInventors: Jie Chen, Pierre Dextraze, Marco Dodier, Katherine S. Takaki
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Patent number: 6211364Abstract: The present invention provides intermediate for the preparation of indane-like compounds which are useful for the modulation of a muscarinic receptor.Type: GrantFiled: June 10, 1999Date of Patent: April 3, 2001Assignee: Eli Lilly and CompanyInventors: Bret E Huff, Michael A Staszak, John S Ward
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Patent number: 6197987Abstract: The present invention relates to chemically stable, polyfunctional, perfluorinated polyorganosiloxanes (POS) comprising on the one hand fluorinated lateral grafts resulting from the hydrosilylation of perfluorinated olefins with SiH units and having alkyl and/or alkyl ester linkages but not ether linkages, and on the other hand other, non-perfluorinated functional units E capable of giving them diverse and varied physical and chemical properties and opening up avenues in numerous applications. Examples of these POS according to the invention are those of the following formula: According to another of its features, the invention relates to a process for the preparation of these polyfunctional perfluorinated POS. Applications: antifoams, agents for lowering surface tension, dirt repellents, antiadhesives, lubricants, oleophobic and/or hydrophobic agents, coatings etc.Type: GrantFiled: February 9, 1999Date of Patent: March 6, 2001Assignee: Rhone-Bouling ChimieInventors: Philippe Jost, Philippe Karrer, Gérard Mignani, Philippe Olier
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Patent number: 6107499Abstract: The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the blood brain barrier. Once in the central nervous system, the prodrug is hydrolyzed into the fatty acid carrier and the drug to release the drug.In a preferred embodiment, the carrier is 4, 7, 10, 13, 16, 19 docosahexa-enoic acid and the drug is dopamine. Both are normal components of the central nervous system. The covalent bond between the drug and the carrier preferably is an amide bond, which bond may survive the conditions in the stomach. Thus, the prodrug may be ingested and will not be hydrolyzed completely into the carrier molecule and drug molecule in the stomach.Type: GrantFiled: June 6, 1995Date of Patent: August 22, 2000Assignee: Neuromedica, Inc.Inventor: Victor E. Shashoua
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Patent number: 5968916Abstract: Fluorinated alkene compounds useful for and methods of controlling nematodes, insects, and acarids that prey on agricultural crops. Polar compounds are particularly useful for systemic control of pests.Type: GrantFiled: January 12, 1998Date of Patent: October 19, 1999Assignee: Monsanto CompanyInventors: Dennis Paul Phillion, Peter Gerrard Ruminski, Gopichand Yalamanchili
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Patent number: 5955631Abstract: The invention provides a method for industrial purification of Capsaicin in high purity from capsinoids (Capsaicin and analogues), more specifically, a method for industrial purification of Capsaicin which comprises contacting capsinoids containing Capsaicin in a hydrophilic solvent with a silver compound in an aqueous solution to form a Capsaicin-silver complex which is soluble in water, and recovering highly pure Capsaicin from the Capsaicin-silver complex without chromatography.Type: GrantFiled: July 16, 1998Date of Patent: September 21, 1999Assignee: Alps Pharmaceutical Ind. Co., Ltd.Inventors: Hisashi Segi, Shuji Yamada, Satoshi Kato, Shoji Murasugi
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Patent number: 5922771Abstract: A compound of the formula ##STR1## wherein R.sup.1 and R.sup.2 independently represent H or an optionally substituted hydrocarbon group; R.sup.3 represents an optionally substituted hydrocarbon group; R.sup.4 represents H or a hydrocarbon group; ring A represents a substituted benzene ring; X represents a C.sub.2-4 alkylene group etc.; and Y represents a bond or a lower alkylene group, or salts thereof is useful as prophylactic or therapeutic agents of diseases related with melatonin activity.Type: GrantFiled: August 19, 1996Date of Patent: July 13, 1999Assignee: Takeda Chemical Industries, Ltd.Inventors: Shigenori Ohkawa, Osamu Uchikawa, Kohji Fukatsu, Masaomi Miyamoto
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Patent number: 5783712Abstract: The invention relates to compounds having at least one vinyl ether group which also contain in the molecule at least one further functional group selected from acrylate, methacrylate, epoxy, alkenyl, cycloalkenyl and vinylaryl groups, to compositions, especially for stereolithography, comprising those vinyl ether compounds, and to a method of producing three-dimensional objects using those compositions.Type: GrantFiled: August 13, 1996Date of Patent: July 21, 1998Assignee: Ciba Specialty Chemicals CorporationInventors: Bettina Steinmann, Adrian Schulthess, Max Hunziker
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Patent number: 5780505Abstract: The compounds of the formula: ##STR1## wherein R.sub.1 is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl or polyfluoroalkyl; R.sub.7 and R.sub.8 are, independently, hydrogen or an acyl substituent selected from the group consisting of formyl, alkanoyl, alkenoyl, alkoxycarbonyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is a phenyl group with either two or three substituents of the following formula: ##STR2## wherein the positions of substitution are R.sub.2,R.sub.3 -, R.sub.2,R.sub.4 -, R.sub.2,R.sub.5 -, R.sub.2,R.sub.6 -, R.sub.3,R.sub.4 -, R.sub.3,R.sub.5 -, and R.sub.2,R.sub.4,R.sub.6 - and R.sub.2 is methyl, ethyl, fluoro, chloro, methoxy or trifluoromethyl; R.sub.3 is methyl, ethyl, fluoro, chloro, methoxy or trifluoromethyl; R.sub.4 is methyl, fluoro, bromo, methoxy or cyano; R.sub.5 is methyl, fluoro, chloro, methoxy, cyano or trifluoromethyl; R.sub.Type: GrantFiled: July 7, 1997Date of Patent: July 14, 1998Assignee: American Home Products CorporationInventors: Madelene M. Antane, David R. Herbst, Geraldine R. McFarlane, Eric G. Gundersen, Bradford H. Hirth, Dominick A. Quagliato, Russell F. Graceffa, John A. Butera