N(prime)-aryl Formimidines (i.e., Benzene-n=ch-hnh, Wherein Substitution May Be Made For Hydrogen, Including Those Bonded Directly To The Benzene Ring Only) Patents (Class 564/245)
  • Publication number: 20140315898
    Abstract: The present invention relates to novel N-arylamide-substituted trifluoroethyl sulfide derivatives of the formula (I) in which X1, X2, X3, X4, R1, R2, R3, n have the meanings given in the description—to their use as acaricides and insecticides for controlling animal pests and to processes and intermediates for their preparation
    Type: Application
    Filed: December 12, 2012
    Publication date: October 23, 2014
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Adeline Koehler, Bernd Alig, Angela Becker, Arnd Voerste, Ulrich Goergens, Reiner Fischer, Wahed Ahmed Moradi, Silvia Cerezo-Galvez, Julia Johanna Hahn, Kerstin Ilg, Hans-Georg Schwarz, Takuya Gomibuchi, Masahito Ito, Daiei Yamazaki, Katsuhiko Shibuya, Eiichi Shimojo
  • Patent number: 8785692
    Abstract: The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Grant
    Filed: November 15, 2012
    Date of Patent: July 22, 2014
    Assignee: Bayer Cropscience AG
    Inventors: Thomas Seitz, Klaus Kunz, Wahed Ahmed Moradi, Joerg Nico Greul, Darren James Mansfield, Ulrich Heinemann, Amos Mattes, Oswald Ort, Jean-Pierre Vors, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste
  • Patent number: 8785649
    Abstract: An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R1 and R2 are each hydrogen or C1-12 alkyl, or R1 and R2 may be bonded together to form C1-7 alkylene; R3 is hydrogen or C1-4 alkylthio; R4, R5, R6, and R7 are each hydrogen, halogen, etc.; and R8 is hydrogen, C1-20 alkyl, C3-8 cycloalkyl, C1-4 haloalkyl, phenyl, a heterocyclic group, or —(CH2)n-Si(R9)(R10)(R11) wherein R9, R10, and R11 are each C1-6 alkyl, and n is an integer of 0 or 1.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: July 22, 2014
    Assignee: Otsuka Agritechno Co., Ltd.
    Inventors: Satoru Masumoto, Hitoshi Mutsutani, Sachi Kimura
  • Patent number: 8748662
    Abstract: The present invention relates to 4-cycloalkyl- or 4-aryl-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: June 10, 2014
    Assignee: Bayer CropScience AG
    Inventors: Klaus Kunz, Ralf Dunkel, Joerg Nico Greul, Oliver Guth, Kerstin Ilg, Darren James Mansfield, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Jean-Pierre Vors
  • Patent number: 8710265
    Abstract: A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO2, is described. In preferred embodiments, the ionic solvent is readily converted back to the nonionic liquid mixture. The nonionic liquid mixture includes an amidine or guanidine or both, and water, alcohol, or a combination thereof. Single component amine solvents that reversibly convert between ionic and non-ionic states are also described. Some embodiments require increased pressure to convert; others convert at 1 atmosphere.
    Type: Grant
    Filed: August 19, 2013
    Date of Patent: April 29, 2014
    Assignees: Queen's University at Kingston, Georgia Tech Research Corporation
    Inventors: Philip G. Jessop, Charles A. Eckert, Charles L. Liotta, David J. Heldebrant
  • Publication number: 20140113987
    Abstract: The invention relates to the use of O-imino-iso-urea compounds as source of radicals to polymerizable compositions comprising these O-imino-iso-urea and to new O-imino-iso-urea compounds.
    Type: Application
    Filed: December 20, 2013
    Publication date: April 24, 2014
    Applicant: BASF SE
    Inventors: Peter NESVADBA, Lucienne BUGNON FOLGER, Antoine CARROY, Marc FALLER, Bruno SPONY
  • Patent number: 8664389
    Abstract: The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(1) having chemical name N-{3-chloro-4-[(3-fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl]-2-furyl]-4-quin-azolinamine and its pharmaceutically acceptable salts. The present invention further relates to intermediates according to formula (8) and formula (9) used in this process.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: March 4, 2014
    Assignee: Natco Pharma Limited
    Inventors: Ramanadham Jyothi Prasad, Bhujanga Rao Adibhatla Kali Satya, Nannapaneni Venkaiah Chowdary
  • Publication number: 20130296436
    Abstract: An amidine compound represented by formula (1): wherein R1 represent a C1-C11 fluoroalkyl group, a C3-C11 fluoroalkenyl group or a C3-C11 fluoroalkynyl group; R2 represent a C1-C3 alkyl group; R3 represent a C1-C3 alkyl group; R4 represent a C3-C6 cycloalkyl group or a C1-C6 alkyl group optionally having one or more halogens and R5 represent a C3-C6 cycloalkyl group or a C1-C6 alkyl group optionally having one or more halogens, said compound having excellent plant disease controlling effect.
    Type: Application
    Filed: December 20, 2011
    Publication date: November 7, 2013
    Inventors: Tohru Inoue, Yoshihiko Nokura
  • Publication number: 20130217884
    Abstract: An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R1 and R2 are each hydrogen or C1-12 alkyl, or R1 and R2 may be bonded together to form C1-7 alkylene; R3 is hydrogen or C1-4 alkylthio; R4, R5, R6, and R7 are each hydrogen, halogen, etc.; and R8 is hydrogen, C1-20 alkyl, C3-8 cycloalkyl, C1-4 haloalkyl, phenyl, a heterocyclic group, or —(CH2)n-Si(R9)(R10)(R11) wherein R9, R10, and R11 are each C1-6 alkyl, and n is an integer of 0 or 1.
    Type: Application
    Filed: November 2, 2011
    Publication date: August 22, 2013
    Applicant: OTSUKA AGRITECHNO CO., LTD.
    Inventors: Satoru Masumoto, Hitoshi Mutsutani, Sachi Kimura
  • Patent number: 8513464
    Abstract: A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO2, is described. In preferred embodiments, the ionic solvent is readily converted back to the nonionic liquid mixture. The nonionic liquid mixture includes an amidine or guanidine or both, and water, alcohol, or a combination thereof. Single component amine solvents that reversibly convert between ionic and non-ionic states are also described. Some embodiments require increased pressure to convert; others convert at 1 atmosphere.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: August 20, 2013
    Assignees: Georgia Tech Research Corporation, Queen's University at Kingston
    Inventors: Philip G. Jessop, Charles A. Eckert, Charles L. Liotta, David J. Heldebrant
  • Publication number: 20130157851
    Abstract: New phenylamidines are described, having general formula (I): and their use for the control of phytopathogenic fungi.
    Type: Application
    Filed: August 18, 2011
    Publication date: June 20, 2013
    Applicant: ISAGRO S.P.A.
    Inventors: Marilena Gusmeroli, Lucio Filippini, Franco Pellacini, Paolo Bravini, Alexia Elmini, Matteo Santino Vazzola, Christian Badaracco
  • Publication number: 20130079557
    Abstract: The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: November 15, 2012
    Publication date: March 28, 2013
    Applicant: BAYER CROPSCIENCE AG
    Inventor: BAYER CROPSCIENCE AG
  • Patent number: 8394991
    Abstract: The present invention relates to 3-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: March 12, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Klaus Kunz, Ralf Dunkel, Joerg Nico Greul, Kerstin Ilg, Birgit Kuhn, Wahed Ahmed Moradi, Thomas Seitz, Darren James Mansfield, Oliver Guth, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Dale Robert Mitchell, Tom Hough, Jean-Pierre Vors
  • Patent number: 8309618
    Abstract: The disclosure relates to methods and materials useful for depolymerizing a polymer. In one embodiment, for example, the disclosure provides a method for depolymerizing a polymer containing electrophilic linkages, wherein the method comprises contacting the polymer with a nucleophilic reagent in the presence of a guanidine-containing compound. The methods and materials of the disclosure find utility, for example, in the field of waste reclamation and recycling.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: November 13, 2012
    Assignees: International Business Machines Corporation, Stanford University
    Inventors: James Lupton Hedrick, Russell Clayton Pratt, Robert M. Waymouth
  • Patent number: 8299302
    Abstract: The present invention relates to 4-cycloalkyl- or 4-aryl-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Grant
    Filed: March 8, 2008
    Date of Patent: October 30, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Klaus Kunz, Ralf Dunkel, Jörg Nico Greul, Oliver Guth, Kerstin Ilg, Darren James Mansfield, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Jean-Pierre Vors
  • Patent number: 8212050
    Abstract: Novel amidine compounds which may be active ingredients in herbicides that are reliably effective at a lesser dose and highly safe, and herbicides containing these compounds as active ingredients are provided. Amidine compounds represented by a formula (1?) and herbicides containing at least one kind of these compounds as active ingredients, [wherein G is an optionally substituted nitrogen-containing heterocyclic group represented by a formula (2?) with a proviso that the number of carbons constituting the nitrogen-containing heterocycle of the nitrogen-containing heterocyclic group is 10 or less and that 2H-Indazole ring is excluded; Q? represents cyano or the like; and A? represents substituted phenyl or the like].
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: July 3, 2012
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Yasuhiro Miyashita, Koichi Kutose, Kazuyuki Tomida, Shigeo Yamada
  • Publication number: 20120122678
    Abstract: The present invention relates to 3-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: January 26, 2012
    Publication date: May 17, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Klaus KUNZ, Ralf Dunkel, Jörg Nico Greul, Kerstin Ilg, Birgit Kuhn, Wahed Ahmed Moradi, Thomas Seitz, Darren James Mansfield, Oliver Guth, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Dale Robert Mitchell, Tom Hough, Jean-Pierre Vors
  • Publication number: 20120108814
    Abstract: Processes for the preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline, salts thereof, and the intermediates used in the process are described.
    Type: Application
    Filed: April 22, 2010
    Publication date: May 3, 2012
    Applicant: AstraZeneca AB
    Inventors: Kay Alison Boardman, Oliver Robert Cunningham, William Robert Fraser Goundry, David Dermot Patrick Laffan
  • Publication number: 20120108696
    Abstract: The invention relates to the use of O-imino-iso-urea compounds as source of radicals to polymerizable compositions comprising these O-imino-iso-urea and to new O-imino-iso-urea compounds.
    Type: Application
    Filed: May 5, 2010
    Publication date: May 3, 2012
    Applicant: BASF SE
    Inventors: Peter Nesvadba, Lucienne Bugnon Folger, Antoine Carroy, Marc Faller, Bruno Spony
  • Publication number: 20120059182
    Abstract: Embodiments of the present disclosure provide for acyclic diaminocarbenes (ADCs) catalysts such as those shown in FIG. 1.1 and in the Examples, methods of making catalysts, methods of using catalysts, and the like. Catalyst of the present disclosure can be useful in various catalytic transformations. Embodiments of the catalyst can be used in hydroamination, cycloisomerization, allylic rearrangement reactions, alkyne hydration reactions, Meyer-Schuster rearrangement reactions, and the like.
    Type: Application
    Filed: September 6, 2011
    Publication date: March 8, 2012
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Sukwon Hong, Hwimin Seo
  • Publication number: 20110301355
    Abstract: Novel amidine compounds which may be active ingredients in herbicides that are reliably effective at a lesser dose and highly safe, and herbicides containing these compounds as active ingredients are provided. Amidine compounds represented by a formula (1?) and herbicides containing at least one kind of these compounds as active ingredients, [wherein G is an optionally substituted nitrogen-containing heterocyclic group represented by a formula (2?) with a proviso that the number of carbons constituting the nitrogen-containing heterocycle of the nitrogen-containing heterocyclic group is 10 or less and that 2H-Indazole ring is excluded; Q? represents cyano or the like; and A? represents substituted phenyl or the like].
    Type: Application
    Filed: August 2, 2006
    Publication date: December 8, 2011
    Inventors: Yasuhiro Miyashita, Koichi Kutose, Kazuyuki Tomida, Shigeo Yamada
  • Publication number: 20110263852
    Abstract: The present invention relates to an improved and novel process for the preparation of high purity crystalline base of Lapatinib of formula-(1) having chemical name N-{3-chloro-4-[(3-fluorobenzyloxy]phenyl}-6-[5-({[2-(methanesulfonyl)ethyl]amino}methyl]-2-furyl]-4-quin-azolinamine and its pharmaceutically acceptable salts.
    Type: Application
    Filed: August 12, 2009
    Publication date: October 27, 2011
    Applicant: Natco Pharma Limited
    Inventors: Ramanadham Jyothi Prasad, Bhujanga Rao Adibhatla Kali Satya, Nannapaneni Venkaiah Chowdary
  • Publication number: 20110237679
    Abstract: Compounds, salts thereof, and tautomers thereof are disclosed. Compositions that include the compounds are disclosed. Methods of making and using the compounds are also disclosed.
    Type: Application
    Filed: December 9, 2009
    Publication date: September 29, 2011
    Applicant: CYTOKINE PHARMASCIENCES, INC.
    Inventor: Thais M. Sielecki-Dzurdz
  • Patent number: 7999137
    Abstract: The present invention relates to bi-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions:
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: August 16, 2011
    Assignee: Bayer Cropscience AG
    Inventors: Klaus Kunz, Jörg Greul, Oliver Guth, Benoît Hartmann, Kerstin Ilg, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Mark Drewes, Ralf Dunkel, Ronald Ebbert, Herbert Gayer, Stefan Hillebrand, Eva-Maria Franken, Olga Malsam, Ulrich Ebbinghaus-Kintscher
  • Patent number: 7855309
    Abstract: The present invention relates to benzyloxy- and phenethyl-substituted phenyl-amidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: December 21, 2010
    Assignee: Bayer CropScience AG
    Inventors: Klaus Kunz, Jörg Greul, Oliver Guth, Benoît Hartmann, Kerstin Ilg, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Mark Drewes, Ralf Dunkel, Ronald Ebbert, Olga Malsam, Eva-Maria Franken
  • Publication number: 20100120615
    Abstract: The present invention relates to 4-cycloalkyl- or 4-aryl-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: March 8, 2008
    Publication date: May 13, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Klaus Kunz, Ralf Dunkel, Jörg Nico Greul, Oliver Guth, Kerstin Ilg, Darren James Mansfield, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Jean-Pierre Vors
  • Publication number: 20100113276
    Abstract: The use of N2-phenylamidines of formula (I) as herbicides is described. In this formula (I), R2, R3, R4, R5 and R6 are different radicals and A is a bond or various 1- or polyatomic bridging elements.
    Type: Application
    Filed: March 4, 2008
    Publication date: May 6, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Birgit Kuhn, Harald Jakobi, Thomas Mueller, Joerg Tiebes, Heinz Kehne, Dirk Schmutzler, Martin Hills, Christopher Rosinger, Klaus Kunz, Mark Wilheim Drewes, Dieter Feucht, Thomas Seitz, Benoit Hartmann, Ralf Dunkel, Joerg Nico Greul, Oliver Guth, Kerstein Ilg, Darren James Mansfeld, Wahed Ahmed Moradi, Peter Dahmen, Ulrike Wachendorf-Neumann, Arnd Voerste, Dale Robert Mitchell, Jean-Pierre Andre Vors, Dale Robert Mitchell, Tom Hough
  • Publication number: 20100105552
    Abstract: The present invention relates to phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: March 8, 2008
    Publication date: April 29, 2010
    Inventors: Klaus Kunz, Ralf Dunkel, Joerg Nico Greul, Kerstin Ilg, Darren James Mansfield, Wahed Ahmed Morradi, Thomas Seilz, Peter Dahmen, Ulrike Wachendorff Neumann, Arnd Voerste
  • Publication number: 20100099558
    Abstract: The present invention relates to dihalophenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: March 4, 2008
    Publication date: April 22, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Klaus Kunz, Ralf Dunkel, Joerg Nico Greul, Kerstin Ilg, Darren James Mansfield, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Ulrike Wachendorff-Neumann
  • Publication number: 20100093533
    Abstract: The present invention relates to 3,4-disubstituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyphenylamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: March 4, 2008
    Publication date: April 15, 2010
    Applicant: Bayer CropSceince AG
    Inventors: Klaus Kunz, Ralf Dunkel, Jörg Nico Greul, Stefan Hillebrand, Kerstin Ilg, Darren James Mansfield, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Jean-Pierre Vors, Oliver Guth
  • Publication number: 20100093534
    Abstract: The present invention relates to fluoroalkylphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: March 8, 2008
    Publication date: April 15, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Klaus Kunz, Jörg Nico Greul, Ulrich Heinemann, Darren James Mansfield, Amos Mattes, Oswald Ort, Thomas Seitz, Wahed Ahmed Moradi, Ulrike Wachendorff-Neumann, Peter Dahmen, Arnd Voerste
  • Publication number: 20100029588
    Abstract: The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.
    Type: Application
    Filed: March 8, 2008
    Publication date: February 4, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Thomas Seitz, Klaus Kunz, Wahed Ahmed Moradi, Jörg Nico Greul, Darren James Mansfield, Urlich Heinemann, Amos Mattes, Oswald Ort, Jean-Pierre Vors, Peter Dahem, Ulrike Wachendorff-Neumann, Arnd Voerste
  • Publication number: 20090197918
    Abstract: The present invention relates to benzyloxy- and phenethyl-substituted phenyl-amidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions.
    Type: Application
    Filed: September 12, 2006
    Publication date: August 6, 2009
    Applicant: Bayer CropScience AG
    Inventors: Klaus Kunz, Jörg Greul, Oliver Guth, Benoît Hartmann, Kerstin Ilg, Wahed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Mark Drewes, Ralf Dunkel, Ronald Ebbert, Olga Malsam, Eva Maria Franken
  • Publication number: 20090143431
    Abstract: The present invention relates to 2,5-di-substituted-4-naphthyloxy-substituted-phenyl-amidine derivatives of formula (I) wherein the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions.
    Type: Application
    Filed: September 12, 2006
    Publication date: June 4, 2009
    Applicant: Bayer CropScience AG
    Inventors: Klaus Kunz, Jorg Greul, Oliver Guth, Benoit Hartmann, Kerstin Ilg, Wahed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Ralf Dunkel, Ronald Ebbert, Eva-Maria Franken
  • Publication number: 20080280992
    Abstract: The present invention relates to bi-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide or insecticide active agents, particularly in the form of fungicide or insecticide compositions, and methods for the control of phytopathogenic fungi or damaging insects, notably of plants, using these compounds or compositions:
    Type: Application
    Filed: September 12, 2006
    Publication date: November 13, 2008
    Applicant: Bayer CropScience AG
    Inventors: Klaus Kunz, Jorg Greul, Oliver Guth, Benoit Hartmann, Kerstin Ilg, Wahed Ahmed Moradi, Thomas Seitz, Peter Dahmen, Arnd Voerste, Ulrike Wachendorff-Neumann, Mark Drewes, Ralf Dunkel, Ronald Ebbert, Herbert Gayer, Stefan Hillebrand, Eva-Maria Franken, Olga Malsam, Ulrich Ebbinghaus-Kintscher
  • Patent number: 7005437
    Abstract: The present invention relates to new substituted aryl and heteroaryl derivatives of general formula wherein A, Ar, n, X, Y1, Y2, Y3, Y4, R1 and R5 are defined as in claim 1, the prodrugs, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties. Thus, the compounds of the above general formula I wherein R5 does not contain a cyano group have, in particular, an antithrombotic effect and a selective factor Xa-inhibiting effect with generally improved compatibility. The compounds of the above general formula I wherein R5 contains a cyano group are valuable intermediate products for preparing the antithrombotic compounds of general formula I.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 28, 2006
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Henning Priepke, Uwe Ries, Herbert Nar, Wolfgang Wienen, Jean-Marie Stassen
  • Patent number: 6946576
    Abstract: A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: September 20, 2005
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Takashi Emura, Tsuyoshi Haneishi
  • Patent number: 6812231
    Abstract: Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.
    Type: Grant
    Filed: February 14, 2002
    Date of Patent: November 2, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tadakiyo Nakagawa, Kazuyuki Sagi, Kaoru Yoshida, Yumiko Fukuda, Masataka Shoji, Shunji Takehana, Takashi Kayahara, Akira Takahara
  • Patent number: 6664295
    Abstract: The invention provides fungicidal compounds of formula I and salts thereof: wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing them and method for combating fungi which comprises applying these.
    Type: Grant
    Filed: August 6, 2001
    Date of Patent: December 16, 2003
    Assignee: Bayer CropScience SA
    Inventors: Vincent Gerusz, Darren James Mansfield, Joseph Perez, Jean-Pierre Vors, Derek Baldwin, Thomas Lawley Hough, Robert Dale Mitchell
  • Patent number: 6534546
    Abstract: Compounds represented by the general formula (1):   (where R1 is SR6 or NR7R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2 and R3 are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3 and Y4 which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: March 18, 2003
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Toshio Honda, Toshihiko Makino, Toshiaki Nagafuji, Yasushi Kitoh, Nobuaki Kimura
  • Patent number: 6410538
    Abstract: Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: June 25, 2002
    Assignee: Ajinomoto Co., Inc.
    Inventors: Tadakiyo Nakagawa, Kazuyuki Sagi, Kaoru Yoshida, Yumiko Fukuda, Masataka Shoji, Shunji Takehana, Takashi Kayahara, Akira Takahara
  • Patent number: 6395735
    Abstract: The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compounds.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: May 28, 2002
    Assignee: Eli Lilly and Company
    Inventors: Sean Patrick Hollinshead, Philip Floyd Hughes, Jose Serafin Mendoza, Joseph Wendell Wilson, Bret Eugene Huff, Charles Howard Mitch, Michael Alexander Staszak, John Stanley Ward
  • Patent number: 6380430
    Abstract: Novel compounds of the formula I in which X, R1, R2, R3, R4 and R5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
    Type: Grant
    Filed: December 29, 2000
    Date of Patent: April 30, 2002
    Assignee: Merck Patent Gesellschaft mit beschraenkterHaftung
    Inventors: Dieter Dorsch, Horst Juraszyk, Werner Mederski, Joachim Gante, Hanns Wurziger, Hans-Peter Buchstaller, Sabine Bernotat-Danielowski, Guido Melzer
  • Patent number: 6376710
    Abstract: The present invention provides novel amidine compounds and novel pesticides containing these amidine compounds as active ingredients. The amidine compounds are expressed by formula I: wherein X and Y are the same or different and are independently halogen, nitro, cyano, or C1-C6 alkyl; Z is C1-C6 haloalkyl or C1-C6 haloalkoxy; R1 is hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or a group of formula: S(O)n—R5 (wherein R5 is C1-C6 alkyl or C1-C6 haloalkyl; and n is 0, 1, or 2); R2 and R3 are the same or different and are independently halogen or C1-C6 haloalkyl; and R4 is a group of formula: NR6R7 or N═CR8R9 (wherein R6 is hydrogen, C1-C6 alkyl, (C1-C6 alkoxy)-carbonyl, (C1-C6 alkoxy) C1-C6 alkyl, or C2-C6 acyl; R7 is hydrogen, C1-C6 alkyl, (C1-C6 alkoxy)carbonyl, or C2-C6 acyl; R8 is C1-C6 alkyl or hydrogen; and R9 is C1-C6 alkoxy, C1-C6 alkyl, or di(C1-C6 alkyl)amino).
    Type: Grant
    Filed: March 28, 2001
    Date of Patent: April 23, 2002
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Osamu Matsumoto, Toru Uekawa
  • Patent number: 6204385
    Abstract: A process for preparing amidines and their salts with inorganic or organic acids comprises reacting the corresponding nitrile with ammonia, C1-C6-alkylamine or hydrazine in the presence of a mercaptocarboxylic acid and in the presence or absence of an in-organic or organic ammonium salt.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: March 20, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Schäfer, Thomas Zierke
  • Patent number: 5958983
    Abstract: The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: September 28, 1999
    Assignee: Pharmacia & Upjohn Company
    Inventors: Michael R. Barbachyn, Fred L. Homa, Antonio Monge, Esteban Santiago, Juan J. Martinez-Irujo, Maria Font
  • Patent number: 5872138
    Abstract: A compound which inhibits human thrombin and which has the general structure ##STR1##
    Type: Grant
    Filed: September 10, 1997
    Date of Patent: February 16, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Adel M. Naylor-Olsen, Gerald S. Ponticello, Joseph P. Vacca, Randall W. Hungate, Craig Coburn, Brian T. Phillips, S. D. Lewis, Mark E. Fraley
  • Patent number: 5869067
    Abstract: The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.
    Type: Grant
    Filed: September 26, 1994
    Date of Patent: February 9, 1999
    Assignee: Centre International De Recherches Dermatologiques Galderma (CIRD Galderma)
    Inventors: Jean-Phillippe Rocher, Jean-Michel Bernardon
  • Patent number: 5866612
    Abstract: A class of acetamidine derivatives of general formula (I) ##STR1## wherein R.sup.1 is hydrogen, C.sub.1-6 hydrocarbyl group optionally substituted by halo, halo, nitro, cyano or a group XR.sup.3 wherein X is oxygen, C(O).sub.m wherein m is 1 or 2, S(O).sub.n wherein n is 0, 1 or 2, or a group NR.sup.4 wherein R.sup.4 is hydrogen or C.sub.1-6 alkyl; and R.sup.3 is hydrogen, C.sub.1-6 alkyl, or a group NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 are independently hydrogen or C.sub.1-6 alkyl, provided that R.sup.3 is not NR.sup.5 R.sup.6 when X is oxygen or S(O).sub.n; R.sup.1a and R.sup.1b are independently selected from hydrogen and halo; R.sup.2 is a C.sub.1-14 hydrocarbyl group which may optionally contain one or two heteroatoms, the group R.sup.2 being optionally substituted by one or more groups independently selected from halo; N.sub.3 ; nitro; CF.sub.3 ; ZR.sup.7 wherein Z is oxygen, C(O).sub.m' wherein m' is 1 or 2, S(O).sub.n' wherein n' is 0, 1 or 2, or a group NR.sup.8 wherein R.sup.
    Type: Grant
    Filed: June 17, 1997
    Date of Patent: February 2, 1999
    Assignee: Glaxo Wellcome Inc.
    Inventors: Jeffrey Alan Oplinger, Edward Patrick Garvey, Eric Steven Furfine, Barry George Shearer, Jon Loren Collins
  • Patent number: RE37438
    Abstract: A class of acetamidine derivatives of general formula (I) wherein R1 is hydrogen, C1-6 hydrocarbyl group optionally substituted by halo, halo, nitro, cyano or a group XR3 wherein X is oxygen, C(O)m wherein m is 1 or 2, S(O)n wherein n is 0, 1 or 2, or a group NR4 wherein R4 is hydrogen or C1-6 alkyl; and R3 is hydrogen, C1-6 alkyl, or a group NR5R6 wherein R5 and R6 are independently hydrogen or C1-6 alkyl, provided that R3 is not NR5R6 when X is oxygen or S(O)n; R1a and R1b are independently selected from hydrogen and halo; R2 is a C1-14 hydrocarbyl group which may optionally contain one or two heteroatoms, the group R2 being optionally substituted by one or more groups independently selected from halo; N3; nitro; CF3; ZR7 wherein Z is oxygen, C(O)m′ wherein m′ is 1 or 2, S(O)n′ wherein n′ is 0, 1 or 2, or a group NR8 wherein R8 is hydrogen or C1-6 alkyl and R7 is hydrogen, C1-6 alkyl or a group NR9R10 wherein R9 and R10 are independently hydrogen or C1-6 alkyl; or R
    Type: Grant
    Filed: May 4, 1999
    Date of Patent: November 6, 2001
    Assignee: Glaxo Wellcome Inc.
    Inventors: Jeffrey Alan Oplinger, Edward Patrick Garvey, Eric Steven Furfine, Barry George Shearer, Jon Loren Collins