Benzene Ring Containing Patents (Class 564/244)
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Publication number: 20140221658Abstract: The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.Type: ApplicationFiled: February 3, 2014Publication date: August 7, 2014Applicant: University of South FloridaInventors: Said M. Sebti, Srikumar Chellappan, Nicholas James Lawrence
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Patent number: 8710265Abstract: A solvent that reversibly converts from a nonionic liquid mixture to an ionic liquid upon contact with a selected trigger, e.g., contact with CO2, is described. In preferred embodiments, the ionic solvent is readily converted back to the nonionic liquid mixture. The nonionic liquid mixture includes an amidine or guanidine or both, and water, alcohol, or a combination thereof. Single component amine solvents that reversibly convert between ionic and non-ionic states are also described. Some embodiments require increased pressure to convert; others convert at 1 atmosphere.Type: GrantFiled: August 19, 2013Date of Patent: April 29, 2014Assignees: Queen's University at Kingston, Georgia Tech Research CorporationInventors: Philip G. Jessop, Charles A. Eckert, Charles L. Liotta, David J. Heldebrant
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Patent number: 8658826Abstract: The invention relates to a method for improving bioavailability of pharmaceutical substances and for allowing the pharmaceutical substances to permeate the blood-brain barrier, the pharmaceutical substances having at least one or more amidine, guanidine, N-hydroxyamidine (amidoxime) or N-hydroxyguanidine functions. The invention also relates to medicaments containing the correspondingly modified pharmaceutical substances.Type: GrantFiled: July 30, 2010Date of Patent: February 25, 2014Assignee: Dritte Patentportfolio Beteiligungsgesellschaft mgH & Co. KGInventors: Bernd Clement, Christiane Wolter-Reeh, Helen Schenk
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Patent number: 8507493Abstract: The present invention relates to inhibitors of 11-?-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.Type: GrantFiled: April 20, 2010Date of Patent: August 13, 2013Assignee: AbbVie Inc.Inventors: Sridhar Peddi, Meena V. Patel, Jeffrey J. Rohde
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Patent number: 8426433Abstract: This invention relates to new chemical compounds, application of these compounds as anticoagulants, pharmaceutical compositions, and plasma-substituting solutions on their basis, and can be used for treating thromboembolic complications of diseases such as myocardial infarction, stroke, and thrombosis of deep veins or a pulmonary artery; and for preventing hypercoagulation conditions in consequence of injuries, surgeries, sepsis, various obstetric pathologies, in disaster medicine, resuscitation, and so on.Type: GrantFiled: June 27, 2008Date of Patent: April 23, 2013Assignee: Obschestvo S Ogranichennoi Otvetsttvennoctiyu “Bionika”Inventors: Elena Ivanovna Sinauridze, Fazoil Inoyatovich Ataullakhanov, Andrey Alexandrovich Butylin, Vladimir Borisovich Sulimov, Alexey Nickolayevich Romanov, Alexey Alexeevich Bogolyubov, Yury Vladimirovich Kuznetsov, Irina Vladimirovna Gribkova, Alexander Sergeevich Gorbatenko, Olga Anatolievna Kondakova
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Patent number: 8362264Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.Type: GrantFiled: August 20, 2004Date of Patent: January 29, 2013Assignee: Dendreon CorporationInventors: Sateesh K. Natarajan, Ofir Moreno, Thomas J. Graddis, David F. Duncan, Reiner Laus, Feng Chen
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Patent number: 8334237Abstract: The present invention relates to oxime ether-, hydrazone- or azomethine-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the amidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.Type: GrantFiled: March 8, 2008Date of Patent: December 18, 2012Assignee: Bayer Cropscience AGInventors: Thomas Seitz, Klaus Kunz, Wahed Ahmed Moradi, Jörg Nico Greul, Darren James Mansfield, Urlich Heinemann, Amos Mattes, Oswald Ort, Jean-Pierre Vors, Peter Dahem, Ulrike Wachendorff-Neumann, Arnd Voerste
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Publication number: 20120129894Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.Type: ApplicationFiled: May 19, 2011Publication date: May 24, 2012Applicant: Acucela Inc.Inventors: Ian L. Scott, Vladimir A. Kuksa, Mark W. Orme, Thomas Little, Anna Gall, Feng Hong
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Patent number: 8183414Abstract: The present invention provides compounds which are N-(1-phenyl-2-arylethyl)-4,5-dihydro-2H-pyrrol-5-amine compounds and are subtype selective modulators of alpha 2B or alpha 2B and alpha 2C adrenoreceptors and are selected from the group of compounds represented by the formulaType: GrantFiled: December 7, 2009Date of Patent: May 22, 2012Assignee: Allergan, Inc.Inventors: Ken Chow, Janet A. Takeuchi, Ling Li, Todd M. Heidelbaugh, Phong X. Nguyen, Evelyn G. Corpuz, Wenkui K Fang, Santosh C. Sinha, Michael E. Garst
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Publication number: 20120053053Abstract: The present invention relates to substituted pyrimidine derivatives, as well as N-oxides thereof and agriculturally acceptable salts thereof, and their use to control undesired plant growth, in particular in crops of useful plants. The invention extends to herbicidal compositions comprising such compounds, N-oxides and/or salts as well as mixtures of the same with one or more further active ingredient (such as, for example, an herbicide, fungicide, insecticide and/or plant growth regulator) and/or a safener. The invention further relates to intermediates useful in the preparation of such compounds, and to processes for their preparation.Type: ApplicationFiled: February 11, 2010Publication date: March 1, 2012Applicant: SYNGENTA CROP PROTECTION, LLCInventors: Mohamed Abdelouahab Boussemghoune, William Guy Whittingham, Caroline Louise Winn, Harry Glithro, Mary Bernadette Aspinall
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Patent number: 8080551Abstract: HIV replication inhibitors having formula (I) defined herein are disclosed. Pharmaceutical compositions containing the HIV replication inhibitors; the use of the HIV replication inhibitors in the treatment of HIV; and processes for preparing the HIV replication inhibitors are also disclosed.Type: GrantFiled: June 26, 2006Date of Patent: December 20, 2011Assignee: Janssen Pharmaceutica N.V.Inventors: Jérôme Emile Georges Guillemont, Patrice Palandijian, Marc René De Jonge, Lucien Maria Henricus Koymans, Hendrik Maarten Vinkers, Frederik Frans Desiré Daeyaert, Jan Heeres, Koen Jeanne Alfons Van Aken, Paulus Joannes Lewi, Paul Adriaan Jan Janssen, Frank Xavier Jozef Herwig Arts, legal representative
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Patent number: 7960459Abstract: The present invention has its object to provide a curable composition which comprises a reactive silyl group-containing organic polymer, does not contain, as a silanol condensation catalyst, any organotin type curing catalyst currently of concern because of the toxic feature thereof, is excellent in surface curability and depth curability and, further, can provide cured products excellent in adhesiveness; the above object can be achieved by a curable composition which comprises: an organic polymer (A) containing a silicon-containing group capable of crosslinking under siloxane bond formation; and a guanidine compound (B-1), as a silanol condensation catalyst (B), represented by the general formula (1): R1N?C(NR12)2??(1) (wherein one of the five R1s is an aryl group and the other four R1s each independently is a hydrogen atom or a hydrocarbon group in which the carbon atom at position 1 is saturated).Type: GrantFiled: February 9, 2007Date of Patent: June 14, 2011Assignee: Kaneka CorporationInventors: Noriko Noro, Toshihiko Okamoto, Ayako Yano, Yoshikazu Morii
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Patent number: 7893288Abstract: A new class of fluorinated or polyhalogenated triazepentadienes are disclosed. The synthesized triazapentadienes are thermally stable, soluble in typical solvents and have several metal binding sites for complexation with metal ions. The compounds are prepared as colorless crystalline solids. Synthesis takes advantage of a reaction with triethylamine. Synthesized triazapentadienes (with and without complexed metals) inhibit bacterial growth of both Gram positive and Gram-negative bacteria.Type: GrantFiled: January 20, 2010Date of Patent: February 22, 2011Assignee: Board of Regents, The University of Texas SystemInventors: H. V. Rasika Dias, Lorraine G. van Waasbergen, Jaime A. Flores
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Publication number: 20110015201Abstract: The present disclosure provides for compounds, pharmaceutical preparations, kits and methods for the inhibition of the Hh pathway and the alleviation of cancer and developmental disorders associated with the Hh pathway.Type: ApplicationFiled: February 12, 2009Publication date: January 20, 2011Inventors: James K. Chen, Joel M. Hyman, Cory A. Ocasio
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Publication number: 20100267738Abstract: The present invention relates to inhibitors of 11-?-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.Type: ApplicationFiled: April 20, 2010Publication date: October 21, 2010Applicant: ABBOTT LABORATORIESInventors: Sridhar Peddi, Meena V. Patel, Jeffrey J. Rohde
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Publication number: 20100167926Abstract: The present invention relates to 3-substituted phenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composition for this purpose, comprising the phenoxyamidines according to the invention. Furthermore, the invention relates to a method for controlling unwanted microorganisms by applying the compounds according to the invention to the microorganisms and/or their habitat.Type: ApplicationFiled: March 4, 2008Publication date: July 1, 2010Applicant: Bayer CropScience AGInventors: Klaus Kunz, Ralf Dunkel, Jorg Nico Greul, Kerstin Ilg, Birgit Kuhn, Wahed Ahmed Moradi, Thomas Seitz, Darren James Mansfield, Oliver Guth, Peter Dahmen, Ulrike Wachendorff-Neumann, Arnd Voerste, Robert Dale Mitchell, Tom Hough
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Patent number: 7723546Abstract: Provided are arylamine compounds having Formula I, II, III, or IV: wherein Ar is the same or different at each occurrence and is aryl having from 6 to 30 carbon atoms or heteroaryl having from 2 to 30 carbon atoms. Also provided are compositions comprising arylamine compounds. The invention also relates to use of such compounds in electronic devices, for example, organic electronic devices.Type: GrantFiled: December 23, 2005Date of Patent: May 25, 2010Assignee: E. I. du Pont de Nemours and CompanyInventors: Norman Herron, Nora Sabrina Radu
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Patent number: 7667077Abstract: A new class of fluorinated or polyhalogenated triazapentadienes are disclosed. The synthesized triazapentadienes are thermally stable, soluble in typical solvents and have several metal binding sites for complexation with metal ions. The compounds are prepared as colorless crystalline solids. Synthesis takes advantage of a reaction with triethylamine. Synthesized triazapentadienes (with and without complexed metals) inhibit bacterial growth of both Gram positive and Gram-negative bacteria.Type: GrantFiled: September 12, 2007Date of Patent: February 23, 2010Assignee: Board of Regents, The University of TexasInventors: H. V. Rasika Dias, Lorraine G. Van Waasbergen, Jaime A. Flores
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Patent number: 7473779Abstract: Novel derivatives of amidines of formula wherein the substituents are defined as in the specification which are useful for inhibiting activity on NO-synthase enzymes producing nitrogen mono oxide and/or trapping the reactive oxygen species (ROS) making them useful for treating various diseases.Type: GrantFiled: September 12, 2003Date of Patent: January 6, 2009Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Serge Auvin, Pierre-Etienne Chabrier de Lassauniere, Jeremiah Harnett, Dominique Pons, Gérard Ulibarri
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Publication number: 20080293751Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.Type: ApplicationFiled: November 15, 2007Publication date: November 27, 2008Inventors: Robert Greenhouse, Ralph New Harris, III, Saul Jaime-Figueroa, James M. Kress, David Bruce Repke, Russell Stephen Stabler
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Patent number: 7425578Abstract: Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or where R6, R7 and R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and —C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group.Type: GrantFiled: September 7, 2006Date of Patent: September 16, 2008Assignee: Biocon LimitedInventors: Nnochiri N. Ekwuribe, Jennifer Riggs-Sauthier
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Patent number: 7423149Abstract: The present invention provides compounds, which, are novel antagonists for D1 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.Type: GrantFiled: December 21, 2004Date of Patent: September 9, 2008Assignee: Schering CorporationInventors: Duane A. Burnett, Wen-Lian Wu, Martin S. Domalski, Mary Ann Caplen, Richard Spring, Jean E. Lachowicz
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Patent number: 7410999Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.Type: GrantFiled: November 20, 2006Date of Patent: August 12, 2008Assignees: University of North Carolinia at Chapel Hill, Georgia State University Research Foundation, Inc., Auburn UniversityInventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvid Kumar, W. David Wilson, Richard R. Tidwell, Chad F. Stephens
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Patent number: 7410989Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.Type: GrantFiled: November 20, 2006Date of Patent: August 12, 2008Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc., Auburn UniversityInventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvid Kumar, W. David Wilson, Richard R. Tidwell, Chad F. Stephens
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Patent number: 7151095Abstract: Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: where R5 is selected from the group consisting of hydrogen and C1 to C4 alkyl, or where R6, R7 and R8 are independently hydrogen or C1 to C4 alkyl; or the esters or pharmacologically acceptable salts thereof. Such compounds may be utilized for the prophylaxis or treatment of various diseases, particularly inflammatory conditions of the GI tract. Methods of treating inflammatory conditions of the GI tract such as inflammatory bowel disease using compounds having the following formula are also disclosed: where R9, R10 and R11 are independently selected from the group consisting of hydrogen and C1 to C4 alkyl, and R12 is selected from the group consisting of hydrogen and —C(O)R13, where R13 is a C1 to C6 alkyl or an aryl group.Type: GrantFiled: October 18, 2004Date of Patent: December 19, 2006Assignee: Nobex CorporationInventors: Nnochiri Nkem Ekwuribe, Jennifer A. Riggs-Sauthier
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Patent number: 7135587Abstract: Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5?, X, Y, B, m, n and o are as defined in Patent Claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart disease, arteriosclerosis, inflammation, tumors. Osteoporosis, infections and restenosis after angioplasty or in pathological processes maintained or propagated by antiogenesis.Type: GrantFiled: November 30, 2001Date of Patent: November 14, 2006Assignee: Merck Patent GmbHInventors: Wolfgang Staehle, Alfred Jonczyk, Oliver Schadt, Simon Goodman
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Patent number: 6946576Abstract: A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.Type: GrantFiled: October 5, 2004Date of Patent: September 20, 2005Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Takashi Emura, Tsuyoshi Haneishi
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Patent number: 6921752Abstract: The invention relates to the use of LTB4 antagonists for preparing a pharmaceutical composition for the treatment or prevention of respiratory diseases in companion and domesticated animals.Type: GrantFiled: March 24, 2003Date of Patent: July 26, 2005Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Franz Birke, Kandace Matzek
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Patent number: 6911477Abstract: This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or prevention of diseases the treatment or prevention of which is mediated by muscarinic receptor agonism.Type: GrantFiled: February 28, 2003Date of Patent: June 28, 2005Assignee: Pfizer Inc.Inventors: Anabella Villalobos, Daniel Yohannes, Jolanta Nowakowski, Dane R. Liston
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Patent number: 6906076Abstract: The present invention concerns alkyl aryl carbonyl compounds that possess anti-infective activity. The compounds of the invention can be used to target specific nuclear localization signal, thereby blocking importation of specific proteins or molecular complex into the nucleus of a cell. The invention encompasses methods of use of such compounds for treatment or prevention of infectious diseases, such as parasitic and viral diseases, including, for example, malaria and acquired immunodeficiency syndrome. The use of the compounds to detect certain specific protein structures which are present in nuclear localization sequences is also taught.Type: GrantFiled: September 12, 2003Date of Patent: June 14, 2005Assignee: Cytokine Pharmasciences, Inc.Inventors: Michael I. Bukrinsky, Anthony Cerami, Peter Ulrich, Bradley Berger
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Patent number: 6861547Abstract: The invention relates to a process suitable for large-scale industrial use for preparing compounds of general formula (I) wherein: R1 denotes a group selected from among methyl, ethyl, propyl, cyclopentyl, cyclohexyl, phenyl, benzyl and —C(Me2)phenyl, each of which is optionally mono-, di- or trisubstituted by hydroxy; and, R2 denotes a group selected from among methyl, ethyl, propyl and benzyl.Type: GrantFiled: May 5, 2002Date of Patent: March 1, 2005Assignee: Boehringer Ingelheim International GmbHInventors: Joerg Brandenburg, Rolf Schmid, Rainer Soyka, Ralf Anderskewitz, Rolf Bauer, Rainer Hamm, Jutta Kroeber
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Patent number: 6852761Abstract: The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.Type: GrantFiled: March 13, 2001Date of Patent: February 8, 2005Assignee: Pharmacia CorporationInventors: Michael S. South, John J. Parlow
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Publication number: 20040248981Abstract: Benzamidine derivatives of formula (I) or pharmaceutically acceptable salts thereof exhibit excellent inhibitory activity against factor Xa and are useful for treating or preventing blood coagulation disorders: 1Type: ApplicationFiled: November 7, 2003Publication date: December 9, 2004Applicant: SANKYO COMPANY, LIMITEDInventors: Koichi Fujimoto, Fumitoshi Asai, Hayao Matsuhashi
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Patent number: 6812231Abstract: Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.Type: GrantFiled: February 14, 2002Date of Patent: November 2, 2004Assignee: Ajinomoto Co., Inc.Inventors: Tadakiyo Nakagawa, Kazuyuki Sagi, Kaoru Yoshida, Yumiko Fukuda, Masataka Shoji, Shunji Takehana, Takashi Kayahara, Akira Takahara
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Patent number: 6677369Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: April 25, 2002Date of Patent: January 13, 2004Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Valentine Joseph Klimkowski, John Joseph Masters, David Mendel, Guy Milot, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
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Patent number: 6664295Abstract: The invention provides fungicidal compounds of formula I and salts thereof: wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing them and method for combating fungi which comprises applying these.Type: GrantFiled: August 6, 2001Date of Patent: December 16, 2003Assignee: Bayer CropScience SAInventors: Vincent Gerusz, Darren James Mansfield, Joseph Perez, Jean-Pierre Vors, Derek Baldwin, Thomas Lawley Hough, Robert Dale Mitchell
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Publication number: 20030229072Abstract: Disclosed are cyclic and acyclic amidines, pharmaceutical compositions containing such amidines, and their use in treating or preventing progesterone receptor mediated diseases or conditions, such as osteopenia and osteoporosis.Type: ApplicationFiled: March 3, 2003Publication date: December 11, 2003Inventors: William H Bullock, Harold C E Kluender, William L Collibee, Robert Dally, Martha E Rodriguez, Ming Wang
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Publication number: 20030119871Abstract: A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, in particular neuropathic pain and headache, specifically migraine, whils displaying fewer ataxic and related side-effects associated with other classes of NMDA receptor antagonists.Type: ApplicationFiled: December 16, 2002Publication date: June 26, 2003Inventors: Neil Roy Curtis, Janusz Jozef Kulagowski, Steve Thomas, Alan Paul Watt
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Patent number: 6534546Abstract: Compounds represented by the general formula (1): (where R1 is SR6 or NR7R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2 and R3 are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4 is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5 is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3 and Y4 which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof.Type: GrantFiled: June 6, 1997Date of Patent: March 18, 2003Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Toshio Honda, Toshihiko Makino, Toshiaki Nagafuji, Yasushi Kitoh, Nobuaki Kimura
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Patent number: 6528491Abstract: The present invention relates to new pyranoside derivatives of general formula I, processes for preparing them as well as their use as medicaments:Type: GrantFiled: October 23, 2001Date of Patent: March 4, 2003Assignee: Boehringer Ingelheim Pharma KGInventors: Ralf Anderskewitz, Kurt Schromm, Franz Birke, Hans Michael Jennewein
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Patent number: 6479524Abstract: Compounds that prolong thrombin time. Exemplary are: (a) rac-4-{3-[5-ethoxycarbonylmethyl-2-methyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, (b) rac-4-{3-[2,5-dimethyl-4-(2-methyl-pyrrolidinocarbonyl)-phenyl]-propargylamino}benzamidine, and (c) 4-[3-(2,5-dimethyl-4-isopropylcarbonyl-phenyl)propargyl-amino]benzamidine.Type: GrantFiled: October 18, 2001Date of Patent: November 12, 2002Assignee: Boehringer Ingelheim Pharma KGInventors: Henning Priepke, Iris Kauffmann-Hefner, Norbert Hauel, Uwe Ries, Herbert Nar, Jean Marie Stassen, Wolfgang Wienen
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Publication number: 20020161052Abstract: Terminally-branched polymeric prodrug platforms capable of high degrees of loading are disclosed. In preferred aspects of the invention, the prodrug platform releases multiple parent compounds after each branch holding the active agent undergoes a benzyl elimination reaction. Methods of preparing the prodrugs and using the same in the treatment of mammals are also disclosed.Type: ApplicationFiled: February 19, 2002Publication date: October 31, 2002Inventors: Yun Hwang Choe, Richard B. Greenwald
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Publication number: 20020151524Abstract: The invention provides fungicidal compounds of formula I and salts thereof: 1Type: ApplicationFiled: August 6, 2001Publication date: October 17, 2002Applicant: Aventis CropScience S.A.Inventors: Vincent Gerusz, Darren James Mansfield, Joseph Perez, Jean-Pierre Vors
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Publication number: 20020107290Abstract: Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated blood-coagulation factor X, and they are useful as agents for preventing or treating various diseases caused by thrombi or emboli.Type: ApplicationFiled: February 14, 2002Publication date: August 8, 2002Applicant: AJINOMOTO CO., INC.Inventors: Tadakiyo Nakagawa, Kazuyuki Sagi, Kaoru Yoshida, Yumiko Fukuda, Masataka Shoji, Shunji Takehana, Takashi Kayahara, Akira Takahara
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Patent number: 6417200Abstract: This application relates to a compound of formula (I), a pharmaceutically acceptable salt of the compound, or a prodrug thereof, as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: May 9, 2000Date of Patent: July 9, 2002Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Valentine Joseph Klimkowski, John Joseph Masters, David Mendel, Guy Milot, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
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Patent number: 6414020Abstract: Amidino and benzamidino compounds, including compounds of the formula: wherein R1-R4, R6-R9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit a number of proteolytic enzymes are described. Also described are methods for preparing the compounds of Formula I.Type: GrantFiled: May 9, 2001Date of Patent: July 2, 2002Assignee: 3- Dimensional Pharmaceuticals, Inc.Inventors: Tianbao Lu, Bruce E. Tomczuk, Carl R. Illig, Richard M. Soll
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Patent number: 6399784Abstract: The present invention relates to processes for the conversion of nitrites to amidines in the preparation of compounds which are antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. The compounds described herein are potent thrombolytics and useful for the inhibition of platelet aggregation in the treatment of thromboembolic disorders.Type: GrantFiled: January 10, 2001Date of Patent: June 4, 2002Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Philip Ma, Pasquale N. Confalone, Hui-Yin Li
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Patent number: 6380430Abstract: Novel compounds of the formula I in which X, R1, R2, R3, R4 and R5 have the meaning indicated in Patent Claim 1, are inhibitors of the coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.Type: GrantFiled: December 29, 2000Date of Patent: April 30, 2002Assignee: Merck Patent Gesellschaft mit beschraenkterHaftungInventors: Dieter Dorsch, Horst Juraszyk, Werner Mederski, Joachim Gante, Hanns Wurziger, Hans-Peter Buchstaller, Sabine Bernotat-Danielowski, Guido Melzer
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Patent number: 6376710Abstract: The present invention provides novel amidine compounds and novel pesticides containing these amidine compounds as active ingredients. The amidine compounds are expressed by formula I: wherein X and Y are the same or different and are independently halogen, nitro, cyano, or C1-C6 alkyl; Z is C1-C6 haloalkyl or C1-C6 haloalkoxy; R1 is hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, or a group of formula: S(O)n—R5 (wherein R5 is C1-C6 alkyl or C1-C6 haloalkyl; and n is 0, 1, or 2); R2 and R3 are the same or different and are independently halogen or C1-C6 haloalkyl; and R4 is a group of formula: NR6R7 or N═CR8R9 (wherein R6 is hydrogen, C1-C6 alkyl, (C1-C6 alkoxy)-carbonyl, (C1-C6 alkoxy) C1-C6 alkyl, or C2-C6 acyl; R7 is hydrogen, C1-C6 alkyl, (C1-C6 alkoxy)carbonyl, or C2-C6 acyl; R8 is C1-C6 alkyl or hydrogen; and R9 is C1-C6 alkoxy, C1-C6 alkyl, or di(C1-C6 alkyl)amino).Type: GrantFiled: March 28, 2001Date of Patent: April 23, 2002Assignee: Sumitomo Chemical Co., Ltd.Inventors: Osamu Matsumoto, Toru Uekawa
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Patent number: 6348478Abstract: The present invention is a biphenylamidine derivative represented by the formula (1) or a pharmaceutically acceptable derivative thereof: and the biphenylamidine derivative or the pharmaceutically acceptable derivative thereof is a novel compound which can be used as a clinically applicable FXa inhibitor.Type: GrantFiled: May 15, 2000Date of Patent: February 19, 2002Assignee: Teijin LimitedInventors: Takayuki Hara, Tomohisa Nakada, Yasunobu Takano, Satoshi Sugiura, Takaharu Tsutsumi, Yoshiharu Takazawa, Reiko Takarada