Halogen Attached Indirectly To The Ammonium Nitrogen By Nonionic Bonding Patents (Class 564/289)
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Publication number: 20150132223Abstract: One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammnonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.Type: ApplicationFiled: November 25, 2014Publication date: May 14, 2015Inventors: David R. Elmaleh, Alan J. Fischman, Timothy M. Shoup
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Publication number: 20140323763Abstract: The invention relates to the use of a substance of the general form (I) to produce an antibacterial and/or antifungal drug, wherein X is a methylene group or a carbonyl group; R1, R2, and R3 are each selected from the group comprising hydrogen, an alkyl group having a chain length of 1-4 carbon atoms, an alkoxy group having a chain length of 1-3 carbon atoms, and a halogen; R4 and R5 are each selected from the group comprising hydrogen and an alkyl group having a chain length of 1-4 carbon atoms; and n=3 to 6.Type: ApplicationFiled: December 21, 2011Publication date: October 30, 2014Applicant: CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIELInventors: Franz Furkert, Bernd Clement, Britta Gerig, Dieter Heber
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Publication number: 20130115168Abstract: One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.Type: ApplicationFiled: September 4, 2012Publication date: May 9, 2013Applicant: The General Hospital CorporationInventors: David R. Elmaleh, Alan J. Fischman, Timothy M. Shoup
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Publication number: 20120207677Abstract: One aspect of the present invention relates to a method of preparing radiofluorinated substituted alkyl, cycloalkyl, aryl, and alkenyl compounds. In a preferred embodiment, potassium fluoride-18 is used. Another aspect of the invention relates to arylammonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the ammonium compound is a tetraaryl ammonium salt. Another aspect of the invention relates to arylsulfonium compounds containing fluorine-18 that are useful as imaging agents. In certain embodiments, the sulfonium compound is a triaryl sulfonium salt. Another aspect of the present invention relates to a method of obtaining a positron emission image of a mammal, comprising the steps of administering to a mammal a compound of the invention, and acquiring a positron emission spectrum of the mammal.Type: ApplicationFiled: August 18, 2006Publication date: August 16, 2012Inventors: David R. Elmaleh, Alan J. Fischman, Timothy M. Shoup
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Publication number: 20120131687Abstract: The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect voltage-gated potassium channel; a method for assaying pesticidal activity of a test substance, which comprises measuring the activity of a voltage-gated potassium channel in a reaction system in which the voltage-gated potassium channel contacts with a test substance, and so on.Type: ApplicationFiled: September 24, 2009Publication date: May 24, 2012Applicant: SUMITOMO CHEMICAL COMPANY, LTD.Inventors: Junko Otsuki, Marc Logghe, Titus Kaletta, Wendy Maddelein
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Publication number: 20110293519Abstract: Provided is radiolabeled ammonium salts and uses thereof as myocardial perfusion agents in molecular imaging.Type: ApplicationFiled: May 26, 2011Publication date: December 1, 2011Applicant: HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITEDInventors: Eyal MISHANI, Ohad ILOVICH, Hana BILLAUER, Sharon DOTAN, Haim DANENBERG, Moshe BOCHER, Galith ABOURBEH, Nanette FREEDMAN
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Publication number: 20110247966Abstract: A composition and method demulsify a produced emulsion from anionic surfactants and polymer (SP) and alkali, surfactants, and polymer (ASP). The produced emulsion is demulsified into oil and water. In one embodiment, the composition includes a surfactant. The surfactant comprises a cationic surfactant, an amphoteric surfactant, or any combinations thereof.Type: ApplicationFiled: April 8, 2010Publication date: October 13, 2011Applicants: NALCO COMPANY, WILLIAM MARSH RICE UNIVERSITYInventors: Olina G. Raney, John Hera, JR., Duy T. Nguyen, Michael K. Poindexter, George J. Hirasaki, Clarence A. Miller
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Publication number: 20110086818Abstract: The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while minimizing effects on non-pain-sensing neurons or other types of cells.Type: ApplicationFiled: March 11, 2009Publication date: April 14, 2011Applicants: Presidents and Fellows of Harvard College, The General Hospital CorporationInventors: Bruce P. Bean, Clifford J. Woolf
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Publication number: 20110073331Abstract: The present invention relates to the use of ionic liquids as flame retardants. The compounds of the invention may be used as flame retardants in various materials without causing damage to the environment and or health of humans or animals. Ionic liquid flame retardants maybe applied alone or in combination with traditional flame retardants. Ionic liquid flame retardants can be applied to finish textile, plastic, leather, paper, rubber or as wild fire flame retardants.Type: ApplicationFiled: November 16, 2010Publication date: March 31, 2011Inventor: Yanjie Xu
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Publication number: 20110039467Abstract: The present invention relates to the use of ionic liquids as flame retardants. The compounds of the invention may be used as flame retardants in various materials without causing damage to the environment and or health of humans or animals. Ionic liquid flame retardants maybe applied alone or in combination with traditional flame retardants. Ionic liquid flame retardants can be applied to finish textile, plastic, leather, paper, rubber, or as wild fire flame retardants.Type: ApplicationFiled: August 9, 2010Publication date: February 17, 2011Applicant: H&C ChemicalInventor: Yanjie Xu
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Publication number: 20100191475Abstract: Materials, methods and a computer system are provided which facilitate the identification and characterization of modulators of potassium ion channels, particularly the HERG channel.Type: ApplicationFiled: March 4, 2010Publication date: July 29, 2010Inventors: Scott Perschke, Ming Liu
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Publication number: 20080280963Abstract: The invention relates to a compound of the general formula (I), as defined herein which is useful for the treatment of a pathology in a patient wherein a CCR3 receptor plays a role in the development of the pathology, and pharmaceutical preparations containing such compound. The invention is also directed to a process for preparing the compound of the general formula (I), and intermediate useful in the preparation.Type: ApplicationFiled: March 19, 2008Publication date: November 13, 2008Applicant: SANOFI-AVENTISInventors: Agnes PAPPNE BEHR, Zoltan KAPUI, Peter ARANYI, Sandor BATORI, Veronika BARTANE BODOR, Lajos T. NAGY, Mihalyne Santa, Marton VARGA, Endre MIKUS, Katalin URBAN-SZABO, Judit VARGANE SZEREDI, Tibor SZABO, Edit SUSAN, Marianna KOVACS
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Patent number: 7432398Abstract: Disclosed are novel inorganic acid salts of sibutramine, which have good physicochemical properties, and crystalline forms thereof. Also disclosed are pharmaceutical compositions comprising the compounds as effective ingredients, methods of preparing the compounds, and the use of the compounds.Type: GrantFiled: January 6, 2006Date of Patent: October 7, 2008Assignee: CJ CorporationInventors: Dong Kwon Lim, Eun Young Yang, Jae Kyoung Ko, Kwang Do Choi, Yong Sik Youn, Hea Ran Suh, Chang Ju Kim
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Patent number: 7429679Abstract: Disclosed is a novel sulphonic acid salt of sibutramine, which has good physicochemical properties. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.Type: GrantFiled: January 6, 2006Date of Patent: September 30, 2008Assignee: CJ CorporationInventors: Dong Kwon Lim, Eun Young Yang, Jae Kyoung Ko, Kwang Do Choi, Yong Sik Youn, Hea Ran Suh, Chang Ju Kim
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Patent number: 7393977Abstract: Disclosed is a novel dicarboxylic acid salt of sibutramine, which has good physicochemical properties. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound.Type: GrantFiled: January 6, 2006Date of Patent: July 1, 2008Assignee: CJ Cheiljedang CorporationInventors: Kwang Do Choi, Yong Sik Youn, Hea Ran Suh, Dong Kwon Lim, Eun Young Yang, Jae Kyoung Ko, Chang Ju Kim
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Patent number: 7300747Abstract: The photobase generator of the invention is represented by the following formula 1: wherein Ar, R, A+ and X? are as defined in the specification. Since the photobase generator of the formula 1 absorbs ultraviolet lights of relatively long wavelength and is photolyzed to generate a strong base efficiently, a composition containing the photobase generator and an episulfide compound is easily cured by polymerization under ultraviolet irradiation.Type: GrantFiled: February 7, 2005Date of Patent: November 27, 2007Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Hitoshi Okazaki, Junya Hayakawa, Motoharu Takeuchi, Masahiro Jono, Kenji Ishii
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Patent number: 7094929Abstract: Two-photon or multi-photon chromophores having a conjugated pi-electron system with donating groups at each end of the pi-electron system providing charge-transfer properties, and having quaternary amine groups that can enhance the solubility of the chromophore in water. In a particular embodiment, the chromophore is based on a distyrylbenzene core, with donor or acceptor groups attached to the central benzene ring.Type: GrantFiled: March 15, 2004Date of Patent: August 22, 2006Assignee: The Regents of the University of CaliforniaInventors: Guillermo C. Bazan, Bernhard Koehler, Alexander Mikhailovsky, Hadjar Benmansour, Bin Liu, Janice W. Hong
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Patent number: 7001973Abstract: A low-viscosity polyisocyanate of reduced color, containing isocyanurate groups is prepared by partially trimerizing an aliphatic and/or cycloaliphatic diisocyanate in the presence of 0.02 to 2% weight, based on the weight of the diisocyanate starting material, of at least one trimerization catalyst containing a quarternary amine component and then removing excess diisocyanate from the reaction medium.Type: GrantFiled: March 26, 2003Date of Patent: February 21, 2006Assignee: Degussa AGInventors: Stephan Kohlstruk, Ingo Bockhoff, Michael Ewald, Rainer Lomoelder
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Electrochemically stable onium salts and electrolytes containing such for electrochemical capacitors
Patent number: 6743947Abstract: Based on the discovery that the melting point and solubility of onium salts are affected by the asymmetry of the substitution on cation, and that the branched substituents effectively shield onium cations from electrochemical reduction, new onium salts are synthesized and high performance electrolytes based on these salts for electrochemical capacitor are provided. The composition of the new electrolyte comprises an onium salt or mixture of such onium salts dissolved in aprotic, non-aqueous solvents or mixture of such solvents. The electrolyte is able to perform at high rate of charge/discharge, at low ambient temperatures, and within wide operating voltage, due to the high solubility, low melting temperature, and the improved reduction stability of the new onium cations, respectively.Type: GrantFiled: May 10, 1999Date of Patent: June 1, 2004Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Kang Xu, Shengping Ding, T. Richard Jow -
Patent number: 6489480Abstract: This description addresses fluorinated amine compounds meeting the general formula R′iArF—ER2, where ArF is a fluoroaryl group, E is nitrogen or phosphorous, each R is independently a C1-C20 hydrocarbyl group; or the two Rs may connect to form an unsubstituted or substituted C2-C20 cycloaliphatic group, R′ is a C1-C20 hydrocarbyl or halogenated hydrocarbyl, and i is 0, 1 or 2. These compounds may be protonated with strong Bronsted acids to form protonated amine compounds that are useful for the preparation of organometallic catalyst-cocatalyst compounds comprising noncoordinating or weakly coordinating anions. The resulting organometallic catalyst-cocatalyst complexes can be effectively used as olefin polymerization catalysts.Type: GrantFiled: December 11, 2000Date of Patent: December 3, 2002Assignee: ExxonMobil Chemical Patents Inc.Inventor: George Rodriguez
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Patent number: 5846907Abstract: Pyrazol-4-ylbenzoyl compounds of the formula I ##STR1## where Z is a 5- or 6-membered heterocyclic saturated or unsaturated radical, Q is a pyrazole ring and L and M are as defined in the specification, their use as herbicidal compounds and to processes for preparing the compounds.Type: GrantFiled: July 30, 1997Date of Patent: December 8, 1998Assignee: BASF AktiengesellschaftInventors: Wolfgang von Deyn, Regina Luise Hill, Uwe Kardorff, Stefan Engel, Martina Otten, Marcus Vossen, Peter Plath, Harald Rang, Albrecht Harreus, Hartmann Konig, Helmut Walter, Karl-Otto Westphalen, Ulf Misslizt
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Patent number: 5679874Abstract: Process for the preparation of dichloro-(2,2)-paracyclophane from p-methylbenzylhalide through 2(3)-chloro-p-methylbenzyltrimethylammonium halide by Hofmann elimination of 2(3)-chloro-p-methylbenzyl trimethylammonium hydroxide in an aqueous solution of alkali metal hydroxide, wherein the 2(3)-chloro-p-methylbenzyltrimethylammonium halide is prepared by chlorination of p-methylbenzyltrimethylammonium halide and the Hofmann elimination is conducted in the presence of dioxane.Type: GrantFiled: July 14, 1992Date of Patent: October 21, 1997Assignee: Daisan Kasei Kabushiki KaishaInventor: Hiroshi Maruyama
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Patent number: 5585522Abstract: Novel amino substituted bishalomethyl benzene compounds, which are precurs to phenylene polymers are disclosed having non-linear optical properties, and which can be converted to electrically conductive polymers. Such polymers are produced by reacting a novel amino substituted bishalomethyl benzene compound with a dialkyl sulfide to make a bis-cycloalkylene sulfonium salt of 2,5,N,N-tetramethylaniline hydrochloride, which is 2,5-(N,N-dimethyl)aniline hydrochloride dimethylene bis-(tetramethylene sulfonium chloride) and reacting this sulfonium salt with alkali metal hydroxide to form a cycloalkylene sulfonium salt precursor polymer, and then heating the precursor polymer under conditions to produce the amino substituted phenylene vinylene polymer, such as poly(2-(N,N-dimethylamino) phenylene vinylene). The polymers can also be made directly by treatment of the bis chlormethyl dimethyl aminobenzene hydrochloride derivative with alkali metal alkoxide.Type: GrantFiled: May 10, 1995Date of Patent: December 17, 1996Assignee: The United States of America as represented by the Secretary of the NavyInventors: John D. Stenger-Smith, William P. Norris, Andrew P. Chafin
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Patent number: 5510532Abstract: Conductive polymers having repeating units of formula (II) ##STR1## formed by chemical or electrochemical oxidation of aniline derivatives of formula (I) ##STR2## wherein R.sub.1 denotes --(CH.sub.2).sub.n --; n is an integer between 2 and 12; R.sub.2, R.sub.3, R.sub.4 and R.sub.5 denote hydrogens or one or two of them can be a halogen atom, methyl, methoxy or nitro groups; and X denotes hydrogen an alkali metal ion, an ammonium ion, an alkyl ammonium ion or an anilinium ion. The conductive polymers have excellent stability toward electrochemical redox cyclization and good processibility.Type: GrantFiled: December 7, 1993Date of Patent: April 23, 1996Assignee: Korea Research Institute of Chemical TechnologyInventors: Suh B. Rhee, Myong-Hoon Lee, Chang-Jin Lee, Bong S. Moon
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Patent number: 5362910Abstract: A germicidal and fungicidal agent can solve the problems of conventional germicidal and fungicidal agents comprising quaternary ammonium salts or amphoteric surface active agents that fungicidal activity is insufficient and metals such as parts of medical instruments are corroded. Furthermore, it has higher germicidal and fungicidal activity against Gram-negative bacteria and filamentous fungi than benzalkonium chloride and excellent safety for human health. It is advantageously applied as a disinfectant for medical uses, a disinfectant for environment, a germicidal and fungicidal agent for fibers, a germicidal and fungicidal agent for cycling cooling water and the like. It has excellent resistance against discoloration, heat resistance, corrosion preventing property and compatibility with anionic surface active agents and can be used for providing all kinds of fibers with the germicidal and fungicidal activity to replace silicone type quaternary ammonium salts.Type: GrantFiled: July 24, 1992Date of Patent: November 8, 1994Assignee: Nicca Chemical Co., Ltd.Inventors: Masahiro Makino, Mikihiko Kurose, Yoshihiro Sasada
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Patent number: 5290806Abstract: 4-4(tert-butylphenyl)-cyclohexylamines and quaternary ammonium salts thereof of the formulae ##STR1## where R.sup.1 is hydrogen, alkyl or alkenyl,R.sup.2 is alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, alkylcycloalkyl, bicycloalkyl, alkenyl, unsubstituted or mon- to trisubstituted phenyl, or unsubstituted or mono- to trisubstituted phenylalkyl,X.crclbar. is a plant-tolerated acid anion,and their plant-tolerated acid addition salts, and fungicides containing these compounds.Type: GrantFiled: July 2, 1993Date of Patent: March 1, 1994Assignee: BASF AktiengesellschaftInventors: Bernhard Zipperer, Eberhard Ammermann, Gisela Lorenz
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Patent number: 5281749Abstract: A process for reducing the residual content of free alkylating agent in aqueous solutions of amphoteric or zwitterionic surface-active agents by aftertreatment with ammonia, an amino acid containing 2 to 8 carbon atoms, or an oligopeptide.Type: GrantFiled: May 28, 1992Date of Patent: January 25, 1994Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Guenter Uphues, Uwe Ploog, Klaudia Bischof, Kenan Kenar, Pavel Sladek
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Patent number: 5198584Abstract: p-phenylenediamines having a quaternary ammonium group and substituted with an electron withdrawing group, derivatives thereof, compositions containing same, and their use as developers for dyeing keratinous fibers, are disclosed.Type: GrantFiled: June 4, 1992Date of Patent: March 30, 1993Assignee: Clairol Inc.Inventors: A. C. Chan, Y. G. Pan, D. L. Chang
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Patent number: 5136097Abstract: The invention relates to a process for the synthesis of sulfonylmethanes and derivatives thereof of the formula M[(RSO.sub.2).sub.2 CH].sub.m (I), in which M represents H, an alkali metal or alkaline earth metal or NR'.sub.4, R' and R are monovalent organic radicals and m represents the valence of M.The process comprises reacting an ionic carbide with a sulfonyl halide, hydrolyzing the product obtained, adding a compound M.sub.y Y.sub.m, in which Y represents an anion capable of reacting with the cation of the ionic carbide to the reaction medium before or after hydrolysis to give a compound which can be separated from compound (I), and y represents the valence of Y.Type: GrantFiled: December 3, 1990Date of Patent: August 4, 1992Assignees: Centre National de la Recherche Scientifique, Hydro-QuebecInventor: Michel Armand
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Patent number: 5110903Abstract: A process is provided for the preparation of a mixture of parylene dimers wherein the distribution of dimers within the mixture is predetermined by the proper selection of halogenated and non-halogenated 2,2-paracyclophane starting material. Since the dimers are free of alpha-halogens, the formation of environmentally undesirable acid halides during the deposition of parylene films and coatings is avoided. Since the dimers are useful in the preparation of inert, transparent, conformal coatings of parylene, desirable chemical and/or physical properties can be imparted to such coating by formation of a dimer mixture of a predetermined composition. The parylene film properties, composition and deposition conditions will be different by varying dimer distribution.Type: GrantFiled: December 20, 1990Date of Patent: May 5, 1992Assignee: Union Carbide Chemicals & Plastics Technology CorporationInventors: Chinsoo Lee, David R. Bassett
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Patent number: 5030756Abstract: Process for conditioning human hair by treatment with selected quaternary ammonium halides, compositions useful for such processes and noval quaternary halides useful in the processes.Type: GrantFiled: August 3, 1990Date of Patent: July 9, 1991Assignee: Clairol IncorporatedInventors: Thomas M. Deppert, Janusz Z. Jachowicz
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Patent number: 4892944Abstract: A process for producing quaternary salts of high purity is disclosed, comprising reacting a tertiary amine or phosphine with a carbonic acid diester to form a corresponding quaternary carbonate and further mixing it with an acid to perform decarboxylation. The quaternary salts thus obtained are useful compounds which can be used in wide fields as various catalysts, electrolytes, additives, medicaments, etc.Type: GrantFiled: May 11, 1988Date of Patent: January 9, 1990Assignee: Mitsubishi Petrochemical Co., Ltd.Inventors: Shoichiro Mori, Kazuhiko Ida, Makoto Ue
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Patent number: 4849559Abstract: A process is provided for the preparation of the dimer, dichloro-[2,2]paracyclophane, which is useful as the starting material for the deposition of conformal parylene coatings employed, for example, in the electronics industry for the protection of various sensitive electronic components.The process avoids the normally low yields of chlorinated dimer formed by the chlorination of 2,2-paracyclophane and instead utilizes the Hofmann elimination of 2(3)-chloro-p-methylbenzyltrimethylammonium hydroxide by conducting the elimination reaction under carefully controlled conditions of reaction temperature and profile, reaction feed configuration, water concentration in the reactor and the use of a cosolvent, certain reaction promoters, or a combination thereof.Type: GrantFiled: May 15, 1987Date of Patent: July 18, 1989Assignee: Union Carbide CorporationInventors: Chinsoo Lee, David R. Bassett
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Patent number: 4705860Abstract: Quaternary ammonium salts of the formulaR.sub.1 --K.sup..sym. A.sup..crclbar.in whichR.sub.1 denotes C.sub.12 -C.sub.26 -alkyl or C.sub.12 -C.sub.26 -alkenyl,K.sup..sym. denotes a group of the formula ##STR1## or --.sup..sym. N(R.sub.2).sub.3, R.sub.2 denotes C.sub.1 -C.sub.3 -alkyl, preferably methyl, and A.sup..crclbar. denotes an anion of one of the following formulae: R.sub.3 SO.sub.3.sup..crclbar., in which R.sub.3 is C.sub.6 -C.sub.9 -alkyl or alkenyl and the sum of C atoms in R.sub.1 and R.sub.3 should be at least 21; ##STR2## in which Hal is fluorine, chlorine, bromine or iodine, R.sub.4 is C.sub.1 -C.sub.5 -alkyl, C.sub.2 -C.sub.5 -alkenyl or C.sub.1 -C.sub.5 -alkoxy in positions 3, 4, 5 or 6, R.sub.5 is hydrogen or hydroxyl in positions 2 or 3, R.sub.6 is COO.sup.- or SO.sub.3.sup.- and R.sub.7 is hydrogen or methyl, with the exception of the salicylate and m-halogenobenzoate ions when combined with C.sub.16 -alkylpyridinium and C.sub.16 -alkyltrimethylammonium.Type: GrantFiled: March 11, 1986Date of Patent: November 10, 1987Assignee: Hoechst AktiengesellschaftInventors: Dieter Ohlendorf, Heinz Hoffmann, Werner Interthal, Ulrich Pintschovius
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Patent number: 4668792Abstract: Substituted [1,1'-biphenyl]-3-ylmethyl compounds carrying leaving groups are intermediates to insecticidal esters.Type: GrantFiled: December 20, 1983Date of Patent: May 26, 1987Assignee: FMC CorporationInventor: Ernest L. Plummer
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Patent number: 4599335Abstract: Diamine derivatives of the formula ##STR1## where R.sup.1 is unsubstituted or substituted alkyl, unsubstituted or substituted aryl or aralkyl, bicycloalkyl, alkoxy, acyl or halogen, n is 0, 1, 2 or 3, R.sup.2 is alkyl, alkenyl or alkoxy, A is unsubstituted or substituted alkylene or unsubstituted or substituted cycloalkylene, R.sup.3, R.sup.4 and R.sup.5 are each unsubstituted or substituted alkyl, alkenyl, alkynyl or unsubstituted or substituted benzyl, or R.sup.3 and R.sup.4, together with A and the two nitrogen atoms bonded to A, form an unsubstituted or substituted piperazine or perhydrodiazepine ring, or R.sup.4 and R.sup.5, together with the nitrogen atom, form an unsubstituted or substituted heterocyclic ring, R.sup.6 is alkyl, alkenyl, alkynyl or unsubstituted or substituted aralkyl or aryloxyalkyl, and Z is an anion of an acid, and fungicides containing these compounds.Type: GrantFiled: July 31, 1985Date of Patent: July 8, 1986Assignee: BASF AktiengesellschaftInventors: Costin Rentzea, Ernst Buschmann, Norbert Meyer, Eberhard Ammermann, Ernst-Heinrich Pommer
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Patent number: 4550206Abstract: Tetrahalobenzene compounds of the formula (I): ##STR1## in which X is independently chloro or, preferably, fluoro and Y is hydrogen or --N.sup.+ R.sub.3 A.sup.- in which each R is independently C.sub.1-4 alkyl and A is a radical capable of forming an anion A.sup.-, are prepared by(a) alkylating a compound of formula (II): ##STR2## or a salt thereof, to form a compound of formula (III): ##STR3## (b) treating the compound of formula (III) with a quaternizing agent of formula RA to form a compound of formula (IV): ##STR4## and (c) partially or completely reductively cleaving the compound of formula (IV) to replace one or both --N.sup.+ R.sub.3 A.sup.- groups by hydrogen.Compounds (I), in which Y is --N.sup.+ R.sub.3 A.sup.-, (III) and (IV) are novel. Compound (I) is useful in the synthesis of insecticides.Type: GrantFiled: January 11, 1984Date of Patent: October 29, 1985Assignee: Imperial Chemical Industries LimitedInventor: Peter J. Richardson
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Patent number: 4545995Abstract: The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such ammonium salts.Type: GrantFiled: July 12, 1983Date of Patent: October 8, 1985Assignee: Schering A.G.Inventors: William C. Lumma, Jr., Ronald A. Wohl
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Patent number: 4528177Abstract: Radioiodine containing phenylbutylammonium salts are valuable imaging agents, particularly for the heart.Type: GrantFiled: October 18, 1982Date of Patent: July 9, 1985Assignee: Eli Lilly and CompanyInventors: Bryan B. Molloy, Mitchell I. Steinberg
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Patent number: 4490473Abstract: Sandwich immunoassays are provided wherein an anti-analyte antibody is coupled with a detector labeled antibody, the anti-analyte antibody being substituted with a N,N,N-trimethylammoniumphenyl group and the detector labeled antibody is an antibody specific to the N,N,N-trimethylammoniumphenyl group. The invention includes novel assays, antigens and antibodies.Type: GrantFiled: March 28, 1983Date of Patent: December 25, 1984Assignee: PanAbInventor: Robert F. Brunhouse
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Patent number: 4446123Abstract: Process of radioimaging the myocardium of mammals using intravenous injection of radiolabeled lipophilic cations of quaternary ammonium, quaternary phosphonium or quaternary arsonium compounds of the formula ##STR1## where R.sub.1 and R.sub.2 are alkyl or aryl groups, R.sub.3 and R.sub.4 are phenyl or benzyl groups, X is Br.sup.-, I.sup.- or Cl.sup.-, L is I.sup.123, I.sup.125, I.sup.131, Br.sup.77, Br.sup.82 or F.sup.18 and Z is nitrogen, phosphorous or arsenic.Type: GrantFiled: October 13, 1982Date of Patent: May 1, 1984Assignee: Hahnemann UniversityInventor: David V. Woo
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Patent number: 4399076Abstract: 2-Vinyl- and 2-ethylcyclopropanes having an aryl group and a nitrogen-containing radical substituted at the 1-position on the ring are provided. The novel 1,1-disubstituted 2-vinylcyclopropane and 2-ethylcyclopropane compounds of this invention have utility in herbicidal applications and are useful reactants. The 2-vinylcyclopropane derivatives are useful monomers for anionic and radical polymerizations.Type: GrantFiled: February 22, 1982Date of Patent: August 16, 1983Assignee: National Distillers and Chemical CorporationInventors: Richard G. Fayter, Jr., Allen L. Hall
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Patent number: 4369041Abstract: A technique is described for dyeing and printing textile materials of cellulose fibers and blends thereof with polyester fibers. The technique involves exposing the textile before and/or during the dyeing or printing sequence to the action of quaternary ammonium compound and a compound capable of releasing ammonia at a temperature within the range of 180.degree.-230.degree. C.Type: GrantFiled: May 12, 1981Date of Patent: January 18, 1983Assignee: Vyzkumny ustav zuslechtovaciInventors: Drahomir Dvorsky, Karel Cerovsky, Jaromir Socha
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Patent number: 4343647Abstract: Compounds are prepared which correspond to the formula ##STR1## wherein R represents hydrogen, chloro, bromo or trifluoromethyl; n represents an integer of from 1 or 2 with the proviso that when R is trifluoromethyl, n is 1; R.sup.1, R.sup.2 and R.sup.3 each independently represent ethyl, n-propyl, n-butyl, isobutyl, ethynyl, vinyl or ethoxymethyl or R.sup.2 and R.sup.3 taken together form an alkylene bridge of 2 to 4 carbon atoms and X represents a non-phytotoxic anion. The compounds have been found to be active plant growth regulatory control agents.Type: GrantFiled: June 9, 1980Date of Patent: August 10, 1982Assignee: The Dow Chemical CompanyInventors: Joseph Dunbar, Theodore W. Holmsen, Herman O. Senkbeil
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Patent number: 4289787Abstract: Quaternary ammonium salts of certain phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such quaternary ammonium salts are disclosed.Type: GrantFiled: December 10, 1979Date of Patent: September 15, 1981Assignee: Eli Lilly and CompanyInventors: Bryan B. Molloy, Mitchell I. Steinberg
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Patent number: 4268439Abstract: Basic azo dyestuffs which are free from sulfonic acid and carboxylic acid groups and correspond to the formula ##STR1## wherein the radical have the below mentioned meaning, water-solubility and drawing speed and are used for dyeing and printing of polymers and copolymers of acrylnitrile, acid-modified polyesters or polyamides, and for dyeing of leather, tanned cotton, polyurethanes, writing liquids, lignin-containing fibres and for coloring of printing pastes.Type: GrantFiled: March 7, 1977Date of Patent: May 19, 1981Assignee: Bayer AktiengesellschaftInventor: Winfried Kruckenberg