Polyquaternary Ammonium Patents (Class 564/295)
  • Patent number: 11111332
    Abstract: An isocyanate polymerization catalyst, a preparation method thereof and a method for preparing polyisocyanates comprising isocyanurate groups by using the same. The catalyst is a carboxylic acid salt containing a di-quaternary ammonium ion. The structure of the catalyst contains hydroxyl-containing aromatic heterocyclic residues. The catalyst is highly active. Only a small quantity of the catalyst is required for the polymerization of isocyanates. The prepared polyisocyanates have color values lower than 25 Hazen, monomer contents of less than 0.5% by weight, high contents of isocyanurates and low viscosities.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: September 7, 2021
    Inventors: Wei Liu, Yonghua Shang, Bin Shi, Yuqi Wang, Lidong Sun, Yuan Li, Weiqi Hua
  • Patent number: 9012365
    Abstract: The present invention generally relates to a method for minimizing the formation of insoluble salts of phenoxy herbicides. The method comprises (1) mixing a compatibility agent, amine salts of phenoxy acid herbicides, and a chemical containing non-amine cations in a aqueous system to form a stable and non-nozzle plugging solution; and (2) application of said stable and non-nozzle plugging solution onto target plants.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: April 21, 2015
    Assignee: Akzo Nobel N.V.
    Inventors: Jinxia Susan Sun, Shawn Zhu, Shuaib A. Khan
  • Patent number: 8748663
    Abstract: Use of compounds of molecular formula (I) as curing activators of mixes having a cross-linkable unsaturated-chain polymer base: ([R1R2R3NR5(NR4R6R7)n](n+1)+)y(n+1)Xy? (I); where: X is an anionic atom or group; R1, R2 and R3, which may be the same or different, are each CmH2m+1, where m ranges between 1 and 3, or CH2CHCH2 or CHCHCH3; R4, R6 and R7, which may be the same or different, are each CH2CHCH2 or CHCHCH3; n is 0 or 1; y is 1 when n is 1; y is 1 or 2 when n is 0; R5 is an aliphatic group C15-C22 when n is 0; and is an aliphatic group C8-C16 when n is 1; when n is 0, at least one of R1, R2, R3 and R5 comprises a double bond.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: June 10, 2014
    Assignee: Bridgestone Corporation
    Inventors: Salvatore Cotugno, Paolo Straffi, Barbara Secchi
  • Patent number: 8703824
    Abstract: The present invention discloses novel cationic amphiphiles containing mannose-mimicking shikimic and quinic acid head-groups and a process for preparing cationic amphiphiles with mannose-mimicking polar head-groups such as, shikimic and quinic acids. The findings described herein also demonstrate that compounds of the present invention can target model DNA vaccines to antigen presenting cells (APCs) such as macrophages and dendritic cells (DCs), via mannose receptors expressed on the cell surface of APCs. The cationic amphiphiles disclosed herein show enhanced cellular and humoral immune response compared to their mannosyl counterpart in dendritic cell (DC, the most professional APC) based genetic immunization in mice. Cationic amphiphiles with mannose-mimicking quinic and shikimic acid head-groups described in the present invention are likely to find future applications in the field of genetic immunization.
    Type: Grant
    Filed: September 14, 2011
    Date of Patent: April 22, 2014
    Assignee: Council of Scientific & Industrial Research
    Inventors: Ramishetti Srinivas, Arup Garu, Sachin B. Agawane, Arabinda Chaudhuri
  • Patent number: 8703902
    Abstract: Polymerizable ionic liquid monomers and their corresponding polymers (poly(ionic liquid)s) are created and found to exhibit high absorption of radio frequency electromagnetic radiation, particularly in the microwave and radar bands. These materials are useful for coating objects to make them less reflective of radio frequency radiation and for making objects that absorb radio frequency radiation and are of minimal reflectivity to radio frequency radiation. Free-radical and condensation polymerization approaches are used in the preparation of the poly(ionic liquids).
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: April 22, 2014
    Assignee: University of Wyoming
    Inventors: Maciej Radosz, Youqing Shen, Huadong Tang
  • Publication number: 20140056791
    Abstract: A solvent solution for capture of CO2 from a stream includes a water soluble polymer comprising an amino group.
    Type: Application
    Filed: June 25, 2013
    Publication date: February 27, 2014
    Inventor: Stephen Alan Bedell
  • Patent number: 8557756
    Abstract: Provided are compositions containing a compatible mixture of a cationic surfactant and an anionic surfactant. A composition according to the invention comprises: (a) a first surfactant of formula I: wherein R, R1, R2, and R3 Y, X, and n are as defined below; (b) a second surfactant that is oppositely charged to the first surfactant.
    Type: Grant
    Filed: June 15, 2011
    Date of Patent: October 15, 2013
    Assignee: Dow Global Technologies LLC
    Inventors: Yongfu Wu, Cynthia L. Rand, Wanglin Yu, Irina V. Graf
  • Patent number: 8404895
    Abstract: New tertiary amine salts are useful as gas hydrate inhibitors in oil and gas production and transportation. These tertiary amine salts give very good separation from an emulsion, are economic and have reduced toxicity concerns.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: March 26, 2013
    Assignee: Baker Hughes Incorporated
    Inventors: Jun Tian, Cheryl R. Bailey
  • Patent number: 8373007
    Abstract: Disclosed is a vinamidinium salt represented by the formula (I): [wherein R1 represents a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group or the like; R2 and R3 are the same or different and each represents a lower alkyl group, or alternatively R2 and R3 may combine together to form a ring; R4 and R5 are the same or different and each represents a lower alkyl group, or alternatively R4 and R5 may combine together to form a ring; X and Y are the same or different and each represents a bromine atom or a chlorine atom; n represents a number of not less than 2; and m represents 0 or n], and methods for synthesizing a heterocyclic ring compound using the salt.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: February 12, 2013
    Assignee: Takeda Pharmaceutical Company Ltd.
    Inventors: Mitsuhisa Yamano, Yasuhiro Sawai, Masahiro Mizuno
  • Patent number: 8283496
    Abstract: Aminoalkyl vinyl ethers comprising alkylenimine units and of the formula H2C?CH—O—X—NH—[Al—]n—H??(I), in which [Al—]n is a linear or branched oligoalkylenimine chain having n alkylenimine units, n is a number of at least 1 and X is a straight-chain or branched C2- to C6-alkylene group, and salts of the monomers I with mineral acids or organic acids and quaternization products of the monomers I with alkyl halides or dialkyl sulfates, processes for the preparation of the compounds of the formula I by addition reaction of alkylenimines with amino-C2- to C6-alkyl vinyl ethers and use of the aminoalkyl vinyl ethers comprising alkylenimine units and of the formula I as monomers for the preparation of polymers for use in the paper industry, as antimicrobial coating materials, in detergents and for the treatment of metal surfaces.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: October 9, 2012
    Assignee: BASF SE
    Inventors: Robert Feuerhake, Daniel Schoenfelder, Hans-Joachim Haehnle, Bernd Bruchmann, Paola Uribe Arocha, Alexander Kraus, Christian Huebsch, Bastiaan Bram Pieter Staal, Ralph Baumgaertner
  • Publication number: 20120238747
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2—Z or —Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and
    Type: Application
    Filed: March 14, 2012
    Publication date: September 20, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Yongliang CHU, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 8222455
    Abstract: Viscoelastic compositions are disclosed herein containing an effective amount of one or more random or structurally defined polycationic quaternary ammonium compounds for controlling the viscoelasticity of the composition. In one aspect, the present technology provides polycationic quaternary ammonium compounds that comprise bis-quaternary compound. The bis-quaternary compounds of the present technology can be symmetric or dissymmetric. In another aspect, the present technology provides viscoelastic well bore treatment fluids comprising water, and at least one polycationic quaternary ammonium compound that comprises a bis-quaternary compound. In another aspect, the present technology provides polycationic carboxylates. Preferred viscoelastic compositions of the present technology maintain viscoelasticity at a temperature greater than about 80° C., preferably greater than about 100° C. or 110° C.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: July 17, 2012
    Assignee: Stepan Company
    Inventor: Paul Knox
  • Patent number: 8158827
    Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds to prepare liposomes and other lipid aggregates suitable for transfection or delivery of compounds to target cells, either in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules, particularly polyanions such as nucleic acids. These compounds have the property, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.
    Type: Grant
    Filed: January 14, 2009
    Date of Patent: April 17, 2012
    Assignee: Life Technologies Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Publication number: 20120053092
    Abstract: Shale hydration inhibition agents of the general formula: wherein R1, R2, R3, R4, R5 and R6 are as defined herein, are described. In addition, the present application is directed to water-based drilling fluids containing these shale hydration inhibition agents and methods of using such agents to inhibit the hydration or swelling of shale during drilling.
    Type: Application
    Filed: October 9, 2009
    Publication date: March 1, 2012
    Applicant: St. Francis Xavier University
    Inventors: D. Gerrard Marangoni, James Nyangulu, Sean Gillis, Amanda MacInnis, Aleisha McLachlan, Josette Landry
  • Publication number: 20110269652
    Abstract: The invention relates to gemini surfactants of formula IA wherein A is a core derived from an organic polyhydroxy compound; R1 and R2 are each independently a hydrophobic group; and R3 and R4 are each independently a surfactant head group. Such surfactants can be used as components of fluids used in the petroleum industry or used in formulating cleansing compositions or detergent compositions.
    Type: Application
    Filed: October 29, 2009
    Publication date: November 3, 2011
    Applicant: ST. FRANCIS XAVIER UNIVERSITY
    Inventors: D. Gerrard Marangoni, T. Bruce Grindley, Nusrat Jahan, Christian Petropolis, Thomas Tran, Nawal Paul
  • Patent number: 8034977
    Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.
    Type: Grant
    Filed: April 27, 2009
    Date of Patent: October 11, 2011
    Assignee: Molecular Transfer, Inc.
    Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
  • Publication number: 20110159597
    Abstract: An activated partial thromboplastin time measuring reagent, comprising a heparin neutralizer is disclosed. An activated partial thromboplastin time measuring method, and a determination method for determining a presence or absence of a blood coagulation inhibitor are also disclosed.
    Type: Application
    Filed: December 22, 2010
    Publication date: June 30, 2011
    Applicant: Sysmex Corporation
    Inventors: Kazuyo Yoshida, Masahiro Okuda
  • Publication number: 20110112328
    Abstract: Cationic surfactants of formula I in which R1, R2, R3, R4, R5, R6, X and n are as defined are useful in a variety of applications, including in cleaners, detergents and personal care products, particularly shampoos and conditioners.
    Type: Application
    Filed: October 21, 2010
    Publication date: May 12, 2011
    Inventors: Tatiana V. Drovetskaya, Eric P. Wasserman, Diane Frank, Susan L. Jordan, Wanglin Yu, Cynthia L. Rand, Irina V. Graf, Edward D. Daugs
  • Patent number: 7915450
    Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds lo prepare liposomes and other lipid aggregates suitable for iransfcclion or delivery of compounds to target cells, cither in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules. particularly polyanions such as nucleic acids. These compounds have the properly, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: March 29, 2011
    Assignee: Life Technologies Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Publication number: 20110017908
    Abstract: Dicationic liquid salts and methods of using such dicationic liquid salts in techniques such as ESI-MS are provided.
    Type: Application
    Filed: February 17, 2009
    Publication date: January 27, 2011
    Applicant: SIGMA-ALDRICH CO.
    Inventor: Armstrong W. Daniel
  • Patent number: 7868208
    Abstract: The present invention relates to a novel class of polymeric compounds having specific highly crosslinked cationic or amphoteric structure. These products are produced without free radical monomers ands are based upon an alkyl diamine which has been reacted to produce a di-tertiary amine compound. The diamine has alkyl groups present the contribute hydrophobicity to the molecule and once crosslinked provide outstanding benefits vis-à-vis conditioning and softening to the hair and skin. The presence of the two amine groups and selection of the proper alkyl group allows for the synthesis of a high molecular weight cationic compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications.
    Type: Grant
    Filed: September 25, 2007
    Date of Patent: January 11, 2011
    Assignee: Surfatech Corporation
    Inventors: Kevin A. O'Lenick, Thomas G. O'Lenick, Anthony J. O'Lenick, Jr.
  • Patent number: 7851653
    Abstract: An antimicrobial polymer is disclosed containing silicon-containing quaternary ammonium groups, the polymer including in its structure repeating units of Formula II: R3N+R0nSiX?4-nY???(II) wherein each R and each R0 is independently a non-hydrolysable organic group; each X? is —OR?, —OH or —O—Si, wherein R? is an alkyl group of 1 to about 22 carbon atoms, or an aryl group of 6 carbon atoms; n is an integer of 0 to 3; and Y is an anionic moiety suitable to form the salt of the repeating units of Formula II. Also disclosed are methods of making such a polymer and imparting sustained antimicrobial properties to a substrate using the polymer.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: December 14, 2010
    Assignee: Biosafe, Inc.
    Inventors: Gerry D. Getman, Matt Bootman, Donald Wagner, Jr., Thomas Ward
  • Publication number: 20100233575
    Abstract: According to the invention there is provided a method of conduction including the steps of providing a quaternary ammonium compound, and causing the quaternary ammonium compound to conduct ionically.
    Type: Application
    Filed: March 26, 2007
    Publication date: September 16, 2010
    Applicant: IONIC POLYMER SOLUTIONS LIMITED
    Inventors: Ian David Brotherston, John Lindley Bancroft
  • Patent number: 7777078
    Abstract: The present invention provides a copper electrolytic solution used to obtain a low-profile electrolytic copper foil with a low surface roughness on the rough side (the opposite side from the glossy side) in the production of an electrolytic copper foil using a cathode drum and, more particularly, to provide a copper electrolytic solution used to obtain an electrolytic copper foil that has excellent transmission loss characteristics at a high frequency, can be finely patterned, and has excellent elongation and tensile strength, both at ordinary and high temperatures. The copper electrolytic solution of the present invention contains (A) at least one quaternary amine salt selected from the group consisting of (a) quaternary amine salts obtained by a reaction between epichlorohydrin and an amine compound mixture composed of a secondary amine compound and a tertiary amine compound, and (b) polyepichlorohydrin quaternary amine salts, and (B) an organic sulfur compound.
    Type: Grant
    Filed: October 10, 2003
    Date of Patent: August 17, 2010
    Assignee: Nikko Materials Co., Ltd.
    Inventors: Masashi Kumagai, Mikio Hanafusa
  • Patent number: 7772435
    Abstract: Disclosed herein is a method comprising: (a) adding an aqueous solution comprising a quaternary ammonium salt to an organic solvent in a vessel under an inert atmosphere, thereby forming a first mixture comprising the quaternary ammonium salt and the solvent; and (b) mixing the first mixture at a temperature and for a time sufficient to remove water and a portion of the solvent from the first mixture, wherein the mixing is performed in an inert atmosphere and the temperature is less than the decomposition temperature of the quaternary ammonium salt.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: August 10, 2010
    Assignee: Sabic Innovative Plastics IP B.V.
    Inventors: Thomas Link Guggenheim, Paul Edward Howson, Farid Fouad Khouri, Lioba Maria Kloppenburg, Matthew Hal Littlejohn, Jacob Lee Oberholtzer, Juan Rodriguez Ordonez, Suresh R. Sriram, David Winfield Woodruff
  • Patent number: 7771611
    Abstract: Novel compositions are provided containing a compound represented by the formula YOSF5 or ZOSF5, where: (a) Y is: (i) an organic cation other than (Me2N)3S+ or (ii) an inorganic cation, provided that when Y is the inorganic cation, the composition further includes a complexing agent; and (b) Z is C1-20 alkyl, aryl, cycloalkyl, combinations thereof, or analogues thereof containing at least one heteroatom, provided that the compound represented by the formula ZOSF5 is a molecular compound. Processes of making the cationic compounds are disclosed as are processes for using the compositions containing cationic compounds in nucleophilic replacement reactions to prepare the compositions containing molecular compounds including the OSF5 group.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: August 10, 2010
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Robert George Syvret, Gauri Sankar Lal, Kristen Elaine Minnich
  • Publication number: 20100197967
    Abstract: The invention concerns a process for purifying ?,?-diiodoperfluorinated compounds of formula 1-(CF2CF2Y)m—I comprising contacting an impure ?,?-diiodoperfluorinated compound with a suitable sequestering agent, with formation of a reversible adduct and separating the ?,?-diiodoperfluorinated compound from the adduct itself. Diammonium dihalogenids of the general formula [R1,2,3N—(CH2)n—NR4,5,6]2*2X (R1-6=alkyl C1-C6n=8-26, X?I, Br, Cl) also called ‘methonium compounds’ are the preferred sequestering agents.
    Type: Application
    Filed: July 3, 2008
    Publication date: August 5, 2010
    Applicant: Politecnico di Milano
    Inventors: Pierangelo Metrangolo, Giuseppe Resnati, Yvan Carcenac
  • Patent number: 7750044
    Abstract: The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid reacted with an alkanolamine to make an ester quaternary compound. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight cationic compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications. These materials are dimethylaminopropyl amine free, which is highly desirable in personal care applications.
    Type: Grant
    Filed: April 1, 2008
    Date of Patent: July 6, 2010
    Assignee: SurfaTech Corporation
    Inventors: Kevin A. O'Lenick, Anthony J. O'Lenick, Jr.
  • Publication number: 20090317908
    Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
    Type: Application
    Filed: May 21, 2009
    Publication date: December 24, 2009
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Alberto Haces, Valentina Ciccarone
  • Patent number: 7601872
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and w
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: October 13, 2009
    Assignee: Life Technologies Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 7598421
    Abstract: The invention provides a lipid of general formula (I) or (II): wherein X1, X2 and R1 to R5 are as defined herein. Such lipids are used to form complexes with a biologically-active material such as a nucleic acid, peptide or small molecule for delivering the biologically-active material to cells. The complexes may incorporate an integrin-binding peptide and, when the biologically-active material is DNA, thereby constitute a LID complex.
    Type: Grant
    Filed: November 8, 2004
    Date of Patent: October 6, 2009
    Assignee: UCL Biomedica PLC
    Inventors: Helen C. Hailes, Alethea B. Tabor, John B. Wong, Michael Pilkington-Miksa, Stephen L. Hart, Christopher A. Hurley
  • Patent number: 7531693
    Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.
    Type: Grant
    Filed: May 24, 2004
    Date of Patent: May 12, 2009
    Assignee: Molecular Transfer, Inc.
    Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
  • Patent number: 7501542
    Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: March 10, 2009
    Assignee: Invitrogen Corporation
    Inventors: Alberto Haces, Valentina C. Ciccarone
  • Patent number: 7479573
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1—R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and w
    Type: Grant
    Filed: January 21, 2005
    Date of Patent: January 20, 2009
    Assignee: Invitrogen Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 7470817
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)I, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and w
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 30, 2008
    Assignee: Invitrogen Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Publication number: 20080161576
    Abstract: Disclosed herein is a method comprising: (a) adding an aqueous solution comprising a quaternary ammonium salt to an organic solvent in a vessel under an inert atmosphere, thereby forming a first mixture comprising the quaternary ammonium salt and the solvent; and (b) mixing the first mixture at a temperature and for a time sufficient to remove water and a portion of the solvent from the first mixture, wherein the mixing is performed in an inert atmosphere and the temperature is less than the decomposition temperature of the quaternary ammonium salt.
    Type: Application
    Filed: December 28, 2006
    Publication date: July 3, 2008
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Thomas Link Guggenheim, Paul Edward Howson, Farid Fouad Khouri, Lioba Maria Kloppenburg, Matthew Hal Littlejohn, Jacob Lee Oberholtzer, Juan Rodriguez Ordonez, Suresh R. Sriram, David Winfield Woodruff
  • Patent number: 7323594
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by -X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: January 29, 2008
    Assignee: Invitrogen Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 7300545
    Abstract: A water-soluble polymer dispersion, process for producing the same and a method of use therefor. In particular, the water-soluble polymer dispersion is one comprising water-soluble polymer fine particles of 100 ?m or less diameter having at least one ionic property selected from among cationic, amphoteric, nonionic and anionic properties together with a polyalkyleneimine and/or a product of polyalkyleneimine modification wherein according to necessity an appropriate amount of water-soluble inorganic salt is incorporated. The provided process enables easily performing the production in dispersed form by means of production facilities of low cost. The obtained water-soluble polymer dispersion is excellent in storage stability and exhibits satisfactory fluidity and solubility so as to enable use in papermaking raw material pretreatments added to papermaking raw materials prior to machine operation and also for enhancement of freeness, increase of sizing degree and enhancement of yield.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: November 27, 2007
    Assignee: Hymo Corporation
    Inventors: Takumi Ohara, Emiko Odaka, Ryousuke Yonemoto
  • Patent number: 7214806
    Abstract: This invention pertains to novel multiple quaternary ammonium salts and their derivatives represented by the formula: wherein each R1, R?1, R2, R?2, R3, R?3, R4 or R5 is independently selected from the group consisting alkyl, aryl, aralkyl and —CH2—CH(OR6)—CH2N+R1R2R3; wherein one or more R6 group is selected from the group consisting of: and wherein An? is an anion. This invention also pertains to novel multiple quaternary ammonium salts and their derivatives represented by the formula: wherein each R1, R?1, R2, R?2, R3 or R?3 group is independently selected from the group consisting of alkyl, aryl, aralkyl and —CH2—CH(OR4)—CH2N+R1R2R3; wherein one or more R4 group is selected from the group consisting of: and wherein An? is an anion.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: May 8, 2007
    Assignee: Sachem, Inc.
    Inventors: Weilian Lang, Charles Little, Victor van de Pas
  • Patent number: 7208605
    Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: April 24, 2007
    Assignee: University of South Alabama
    Inventor: James Hillard Davis, Jr.
  • Patent number: 7193111
    Abstract: The present invention relates to a novel class of polymeric compounds having specific quaternized amine based upon a dimer acid reacted with an dimethyl amino propyl amine to make an amido amine, which is subsequently reacted to make a polymeric quaternary compound. Dimer acid is a C-36 diacid having a cyclic structure and two amine groups that allow for the synthesis of a high molecular weight cationic compound which is extremely substantitive to human skin and are well tolerated by human tissue making them suitable for use preparation of barrier products for personal care applications.
    Type: Grant
    Filed: August 2, 2004
    Date of Patent: March 20, 2007
    Assignee: Surfa Tech Corporation
    Inventors: Thomas G. O'Lenick, Anthony J. O'Lenick, Jr.
  • Patent number: 7189865
    Abstract: The current invention provides novel thiomolybdate derivatives, methods of making novel thiomolybdate derivatives, pharmaceutical compositions of novel thiomolybdate derivatives, methods of using novel thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation and methods of using pharmaceutical compositions of thiomolybdate derivatives to treat diseases associated with aberrant vascularization, copper metabolism disorders, neurodegenerative disorders, obesity or NF-?B dysregulation.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: March 13, 2007
    Assignees: Attenuon, LLC, Regents of the University of Michigan
    Inventors: Robert J. Ternansky, Andrew Mazar, Patricia L. Gladstone, Dimitri Coucouvanis, Amy L. Allan, Sean M. O'Hare, Melissa L. P. Price, Steven Robert Pirie-Shepherd, Fernando Donate
  • Patent number: 7166745
    Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)1, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —CH2)p—D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: January 23, 2007
    Assignee: Invitrogen Corporation
    Inventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
  • Patent number: 7026512
    Abstract: The present invention relates to novel tertiary alkanolamines useful as catalysts for preparing polyurethane foams and as additives to reduce the dynamic surface tension of aqueous solutions. The tertiary alkanolamines may be represented by formula (I): wherein A, R1–R6, and n are defined herein, and where the tertiary alkanolamine is acid-blocked with a carboxylic acid.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: April 11, 2006
    Assignee: Air Products and Chemicals, Inc.
    Inventors: William R. Raymond, Juan Jesus Burdeniuc, Khalil Yacoub
  • Patent number: 7002042
    Abstract: The present invention relates to synthetic cationic lipids, liposome formulations and the use of such compounds to introduce functional bioactive agents into cultured cells.
    Type: Grant
    Filed: August 20, 2002
    Date of Patent: February 21, 2006
    Assignee: Vanderbilt University
    Inventor: Xiang Gao
  • Patent number: 6960690
    Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: November 1, 2005
    Assignee: Mirns Bio Corporation
    Inventors: Jon A. Wolff, James E. Hagstrom, Vladimir G. Budker, Vladimir S. Trubetskoy, Paul M. Slattum, Lisa J. Hanson
  • Patent number: 6914041
    Abstract: The present invention relates to laundry detergent compositions which provide enhanced hydrophilic soil cleaning benefits comprising a zwitterionic polyamine, a surfactant system comprising a mid-chain branched surfactant, and carrier and other adjunct ingredients.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: July 5, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Kenneth Nathan Price, Eugene Paul Gosselink
  • Patent number: 6903059
    Abstract: The present invention relates to detergent compositions comprising a polyamine with defined end capping units and a mid-chain branched surfactant and also optionally containing a bleach agent, aluminosilicate, silicate, and/or detersive enzyme.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: June 7, 2005
    Assignee: The Procter & Gamble Company
    Inventors: Kenneth Nathan Price, Eugene Paul Gosselink, Randall Scott Deinhammer
  • Patent number: 6900313
    Abstract: The invention relates to chiral ionic liquids of the general formula [A]n+[Y]n?, whereby n=1 or 2, the anion [Y]n? is the anion of an organic or inorganic proton acid and the cation [A]+ an optically active organic ammonium cation with up to 50 carbon atoms, at least one chirality center and at least one functional group that can produce a coordination by forming hydrogen bridges or by providing free electron pairs. At least one chirality center is provided with a distance of up to 5 atomic bonds from the functional group. The invention also relates to a method for producing said chiral ionic liquids and to the use thereof in methods for the asymmetric synthesis, the asymmetric catalysis and for separating racemates.
    Type: Grant
    Filed: January 29, 2001
    Date of Patent: May 31, 2005
    Inventors: Peter Wasserscheid, Wilhelm Keim, Carsten Bolm, Andreas Bösmann
  • Patent number: 6812198
    Abstract: The present invention relates to hydrophobically modified polyamines and laundry detergent compositions which comprise said polyamines, said compositions comprising: A) from about 0.01%, preferably from about 0.
    Type: Grant
    Filed: August 30, 2002
    Date of Patent: November 2, 2004
    Assignee: The Procter & Gamble Company
    Inventors: Jeffrey Scott Dupont, Eugene Paul Gosselink, Kenneth Nathan Price, Robert Henry Rohrbaugh