Amino Nitrogen Is Bonded Directly To The Aryl Ring Or Ring System And Is Part Of The Chain Patents (Class 564/326)
  • Patent number: 8501996
    Abstract: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: August 6, 2013
    Assignee: Biometrix Technology Inc.
    Inventors: Tae Sun Kim, Keum Soo Song, Jung Hoon Kim, Hyung Sub Kim
  • Patent number: 8492508
    Abstract: A polyimide represented by formula (6) is provided. The polyimide is fabricated by performing a polycondensation reaction with a amine compound shown in formula (4) and a dianhydride compound shown in formula (5) as monomers. In formulas (5) and (6), Ar represents aromatic group, and n represents a positive integer.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: July 23, 2013
    Assignee: National Taiwan University of Science and Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8399701
    Abstract: The present invention relates to a process for the preparation of di- and polyamines of the diphenylmethane series, and to the preparation of di- and polyisocyanates of the diphenylmethane series from these di- and polyamines. The di- and polyamines of the diphenylmethane series are prepared by the reaction of aniline and formaldehyde in the presence of hydrochloric acid. In the present invention, the formaldehyde employed is used as an aqueous solution which contains less than 0.001 wt % of metal ions which are divalent and/or more than divalent.
    Type: Grant
    Filed: May 16, 2008
    Date of Patent: March 19, 2013
    Assignee: Huntsman International LLC
    Inventors: Robert Henry Carr, Peter Muller, Rabah Mouazer
  • Patent number: 8367797
    Abstract: A polyamide represented by formula (6) is provided. The polyamide is fabricated by performing a polycondensation reaction with amine compound shown in formula (4) and an acid or derivative thereof shown in formula (5) as monomers. In formulas (5) and (6), X represents aromatic groups or aliphatic groups. In formula (5), R represents OH group or halogen.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: February 5, 2013
    Assignee: National Taiwan University of Science and Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8304514
    Abstract: The invention provides a conjugated polymer, a method for preparing the same, and optoelectronic devices employing the same. The conjugated polymer includes a structure represented by Formula (I), wherein, R1 is independently an octyl or dodecyl group, R2 is independently an H or 1,1,3,3-tetramethylbutyl, and, n is an integer larger than 1.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: November 6, 2012
    Assignee: National Taiwan University of Science & Technology
    Inventor: Der-Jang Liaw
  • Publication number: 20110275783
    Abstract: A polyamide represented by formula (6) is provided. The polyamide is fabricated by performing a polycondensation reaction with amine compound shown in formula (4) and an acid or derivative thereof shown in formula (5) as monomers. In formulas (5) and (6), X represents aromatic groups or aliphatic groups. In formula (5), R represents OH group or halogen.
    Type: Application
    Filed: August 23, 2010
    Publication date: November 10, 2011
    Applicant: National Taiwan University of Science and Technology
    Inventor: Der-Jang Liaw
  • Patent number: 8013188
    Abstract: The present invention relates to novel iminecalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA by using the self-assembled monolayer, and oligo-DNA chip prepared by the method. Also, the present invention relates to novel aminocalixarene derivatives, method of preparation thereof, and self-assembled monolayer prepared by the method, fixing method of oligo-DNA wherein the oligo-DNA is voluntarily fixed by molecular recognition on said self-assembled monolayer in a liquid phase, and oligo-DNA chip prepared by the method.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: September 6, 2011
    Assignee: Biometrix Technology Inc.
    Inventors: Tae Sun Kim, Keum Soo Song, Jung Hoon Kim, Hyung Sub Kim
  • Patent number: 7858825
    Abstract: The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: December 28, 2010
    Assignee: Colorado State University Research Foundation
    Inventors: Michio Kurosu, Dean Crick
  • Publication number: 20100048832
    Abstract: Alkylated 4-aminobenzyl-4-aminocyclohexane curing agents that can be used, for example, in polyurea, polyurethane and urea/urethane hybrid elastomeric, epoxy resin, epoxy adhesive, epoxy composites and/or coating compositions and polymeric compositions comprising these curing agents are provided herein. In one embodiment, the curing agent comprises a compound having the following Formula I: wherein R1 and R2 are each independently a hydrogen, an alkyl group comprising from 1 to 20 carbon atoms, or combinations thereof. In another embodiment, a method of making the polymeric composition comprising the compound having the above Formula I is provided herein.
    Type: Application
    Filed: August 22, 2008
    Publication date: February 25, 2010
    Applicant: AIR PRODUCTS AND CHEMICALS, INC.
    Inventors: Gamini Ananda Vedage, Courtney Thompson Thurau, Mark David Conner, Ellen Margaret O'Connell
  • Patent number: 7253321
    Abstract: The invention provides a process for the preparation of polyamines of the diphenylmethane series. This process comprises a) reacting aniline and formaldehyde in a molar ratio of 1.5:1 to 6:1, in the presence of an acid catalyst at temperatures of 20° C. to 100° C., in which the water content in the acid reaction mixture is <20 wt. % and a degree of protonation of <15% is established, and b) increasing the temperature of the reaction to a temperature of 110° C. to 250° C. when the ratio of the weight contents of p-aminobenzylaniline to 4,4?-MDA in the reaction mixture falls below a value of 1.00.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: August 7, 2007
    Assignee: Bayer MaterialScience AG
    Inventors: Torsten Hagen, Daniel Koch, Hans-Georg Pirkl, Fritz Pohl, Stefan Wershofen, Rudolf Uchdorf, Richard Adamson
  • Patent number: 7186857
    Abstract: The present invention relates to a process for the preparation of di- and polyamines of the diphenylmethane series, and to the preparation of di- and poly-isocyanates of the diphenylmethane series from these di- and poly-amines. The di- and poly-amines of the diphenylmethane series are prepared by the reaction of aniline and formaldehyde in the presence of hydrochloric acid. In with the present invention, the hydrochloric acid employed contains less than 0.001 wt. % of metal ions which are divalent and/or more than divalent.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: March 6, 2007
    Assignee: Bayer MaterialScience AG
    Inventors: Heinz-Herbert Müller, Stefan Wershofen, Stefan Grabowski
  • Patent number: 7034015
    Abstract: The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said compounds in the manufacture of pharmaceutical preparations.
    Type: Grant
    Filed: August 28, 2002
    Date of Patent: April 25, 2006
    Assignee: Leo Pharma A/S
    Inventors: Erik Rytter Ottosen, Anne Marie Horneman, Xifu Liang
  • Publication number: 20010003749
    Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.
    Type: Application
    Filed: January 3, 2001
    Publication date: June 14, 2001
    Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
  • Patent number: 6166013
    Abstract: Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: December 26, 2000
    Assignee: Abbott Laboratories
    Inventors: Michael J. Coghlan, Jay R. Luly, Jeffrey M. Schkeryantz, Alan X. Wang
  • Patent number: 6063815
    Abstract: This invention provides compounds of Formula I having the structure ##STR1## wherein Y is ##STR2## R.sup.1 and R.sup.2 are each, independently, hydrogen, alkyl of 1-6 carbon atoms, halogen, perfluoroalkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, thienyl, furyl, phenyl or phenyl mono-, di- or tri-substituted with trifluoromethyl, chloro, methoxy, or trifluoromethoxy;R.sup.3 and R.sup.4 are each, independently, hydrogen, carboxyl, hydroxyl, hydoxyalkyl of 1-6 carbon atoms, hydroxyalkanoyl of 1-6 carbon atoms, aryloxycarbonyl of 7-13 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, perfluoroalkoxycarbonyl of 2-7 carbon atoms, alkyl of 1-6 carbon atoms, perfluoroalkyl of 1-6 carbon atoms, aminoalkyl of 1-6 carbon atoms, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, tetrazolyl, mercapto, alkylsulfanyl of 1-6 carbon atoms, nitrile, nitro, amino, --NHSO.sub.2 CF.sub.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: May 16, 2000
    Assignee: American Home Products Corporation
    Inventor: Paul J. Dollings
  • Patent number: 6028224
    Abstract: A synthesis of fluoxetine is disclosed. The process begins with a lower alkyl ester of 3-benzoylpropionic acid, which is reduced in the presence of a chiral ligand to produce the corresponding .gamma.-hydroxy ester, and the ester is cleaved. The free acid is then condensed with the alcohol to form a .gamma.-lactone, which is treated with ammonia to provide the .gamma.-hydroxy amide. The amide undergoes a Hoffman rearrangement to provide a 2-oxo-1,3 oxazine, which is reduced to 3-(methylamino)-1-phenyl-1-propanol. The alcohol is deprotonated and reacted with a 4-chloro- or 4-fluoro benzotrifluoride to provide fluoxetine free base.
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: February 22, 2000
    Assignee: Sepracor Inc.
    Inventors: James Wallace Hilborn, Alex Roger Jurgens, Chris Hugh Senanayake
  • Patent number: 5750742
    Abstract: Triarylmethanes of the formula ##STR1## where m is from 1 to 100,L.sup.1 and L.sup.2 are each C.sub.2 -C.sub.4 -alkylene,R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sup.3 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.4 -alkyl,R.sup.4, R.sup.5,R.sup.6 and R.sup.7 are each hydrogen, substituted or unsubstituted C.sub.1 -C.sub.4 -alkyl, or substituted or unsubstituted phenyl,Q is aryl, andAn.sup..crclbar. is the equivalent of an anion,are useful for dyeing or printing polymeric material.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: May 12, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Gunter-Rudolf Schroder, Udo Mayer, Ulf Baus, Johannes Peter Dix
  • Patent number: 5691384
    Abstract: The present invention relates to a method of using triaryl-ethylene derivatives in the treatment or prevention bone tissue loss or osteoporosis.
    Type: Grant
    Filed: October 11, 1995
    Date of Patent: November 25, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventor: Alan J. Bitonti
  • Patent number: 5665756
    Abstract: Novel aminoalkyloximes of the formula ##STR1## wherein: a. X is hydrogen, loweralkyl, loweralkoxy, halogen, trifluoromethyl, or a group of the formula ##STR2## wherein Y is hydrogen or loweralkyl, and p is 1 or 2; b. A is a group of the formula ##STR3## c. R.sup.1 and R.sup.2 are independently hydrogen or lowerakyl; and d. m is 2 to 6 and n is 0, or 2 to 6, inclusive, serotonin reuptake inhibitors, useful for treating depression and obsessive compulsive disorders are described. Also described are precursors of and processes for the preparation of such aminoakyloximes.
    Type: Grant
    Filed: August 3, 1994
    Date of Patent: September 9, 1997
    Assignee: Hoechst Marion Roussel, Inc.
    Inventors: Gregory M. Shutske, Brian S. Freed, John D. Tomer, IV, R. Richard L. Hamer
  • Patent number: 5525633
    Abstract: The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.
    Type: Grant
    Filed: June 15, 1994
    Date of Patent: June 11, 1996
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Donald P. Matthews, Alan J. Bitonti, William A. Van Sickle, Donald A. Kaplan
  • Patent number: 4691059
    Abstract: This invention describes UV-stabilized step growth polymers such as polyesters, polyurethanes, polycarbonates, and combinations thereof. The UV-stabilizing moieties present in these polymers comprise chemically bound, pendant ortho-hydroxydiphenyl ketone based moieties. The polymers are especially useful as protective films and fibers which are highly resistant to ultraviolet (UV) and sunlight degradation.
    Type: Grant
    Filed: August 30, 1985
    Date of Patent: September 1, 1987
    Assignee: Minnesota Mining and Manufacturing Company
    Inventors: Sumita B. Mitra, Smarajit Mitra
  • Patent number: 4656257
    Abstract: A disazo compound is provided which is represented by the formula (I): ##STR1## (wherein, R.sub.1 and R.sub.2 each stands for hydrogen, a lower alkyl group with 1-4 carbon atoms, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aromatic group, or a substituted or unsubstituted hetero ring group. R.sub.1 and R.sub.2 may be the same or different. And, R.sub.1 and R.sub.2 may mutually bond to form a ring).This disazo compound may be obtained by diazotating 2.6-diaminoanthraquinone and reacting the same with a coupler represented by the formula (IV): ##STR2## (wherein, R.sub.1 and R.sub.2 are the same as defined above). Further, a multilayer type electrophotographic element is provided which comprises a charge carrier generating layer and a charge transfer layer and uses, as a charge carrier generating substance, a disazo compound represented by the formula (I).
    Type: Grant
    Filed: June 20, 1985
    Date of Patent: April 7, 1987
    Assignee: Ricoh Co., Ltd.
    Inventor: Mitsuru Hashimoto
  • Patent number: 4605785
    Abstract: The invention relates to new 1,1-diphenylpropan-1-ol derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,R.sub.3 is halogen, trihalomethyl, alkyl having from one to 5 carbon atoms or alkoxy having from one to 5 carbon atoms,R.sub.4 is phenyl optionally substituted by one or more identical or different substituents selected from the group of halogen, trihalomethyl, alkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, hydroxyl, carboxyl or substituted carboxyl; dialkylaminocarbonyl or alkoxycarbonyl containing from one to 4 carbon atoms in the alkyl and alkoxy moieties, respectively,n is 1, 2, 3, 4, or 5.According to another aspect of the invention there are provided processes for the preparation of the compounds of formula (I).
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: August 12, 1986
    Assignee: Richter Gedeon Vegyeszeti Gyar RT
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szabolcs Szeberenyi, Laszlo Szporny, Sandor Gorog, Istvan Hajdu
  • Patent number: 4596891
    Abstract: There is disclosed diamines of the formula ##STR1## wherein R.sub.6 is H, Cl, or CH.sub.3 ; andR.sub.8 " is H, Cl, or CH.sub.3, with the provisos that(a) if R.sub.8 " is H or CH.sub.3, R.sub.7 " is CH.sub.3 ; and(b) if R.sub.8 " is Cl, R.sub.7 " is F; and(c) if R.sub.6 and R.sub.8 " are both H, R.sub.7 " is any of CH.sub.3, F, CF.sub.3, trifluoromethoxy, trifluoromethylsulfonyl, cyclohexyl, C.sub.2 -C.sub.10 alkyl, p-chlorophenoxy or p-chlorophenyl alkyl having 7 or 8 carbon atoms. The diamines have algicidal activity.
    Type: Grant
    Filed: November 20, 1980
    Date of Patent: June 24, 1986
    Assignee: Duphar International Research B.V.
    Inventors: Jaap van Gilse, Gerard B. Paerels
  • Patent number: 4360649
    Abstract: A curable resin composition comprising an epoxy resin, a hardener and an epoxy compound-dialkylamine adduct as a latent hardener. The composition is excellent in storage stability at ambient temperatures and rapidly curable under heating conditions, and is usable as adhesives, paints, molding materials, casting materials and so on.
    Type: Grant
    Filed: April 15, 1981
    Date of Patent: November 23, 1982
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Kunimasa Kamio, Koichi Okuno, Satoru Haraguchi, Hiroyuki Yamaguchi, Koichi Ohashi