Benzene Ring Containing Patents (Class 564/305)
  • Patent number: 10407399
    Abstract: The presently-disclosed subject matter relates to analyte-activated photolabile compounds. The compounds include the formula: wherein Z includes a maskable molecule; L is selected from a bond, C, C(O), O, alkyl, (O)alkyl, and alkoxy; R1 is selected from H, halogen, alkyl, and acyl; each R2 is independently selected from H, alkyl, aryl, and acyl, and is optionally substituted with one or more heteroatoms independently selected from COOH and COO(alkyl); and R3 is selected from H, alkyl, aryl, halogen, CN, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, CHO, COOH, COO(alkyl), COO(aryl), PO3H2, and SO3H, and is optionally substituted with one or more heteroatoms independently selected from N, O, and S, halogen, OH, O(alkyl), O(aryl), SH, S(alkyl), S(aryl), amine, NO2, CHO, COO, COOH, COO(alkyl), COO(aryl), C(O)NR2, PO3H2, and/or SO3H. Also provided are methods of detecting calcium and treating a subject with the analyte-activated photolabile compounds.
    Type: Grant
    Filed: September 1, 2016
    Date of Patent: September 10, 2019
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Luke D. Lavis, Jonathan B. Grimm, Laurel M. Heckman, Eric R. Schreiter
  • Patent number: 9926260
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: March 27, 2018
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Patent number: 9758457
    Abstract: The invention relates to a method for converting a precatalyst complex to an active catalyst complex, wherein the precatalyst complex and the active catalyst complex comprise a ruthenium atom and an optically active ligand that is insoluble in water, and the active catalyst complex furthermore comprises a monohydride and a water molecule. The method comprises the steps of providing water as an activation solvent system with a pH value equal or below 2, and solving said precatalyst complex, an acid, and hydrogen therein. The invention further relates to a method for manufacturing a catalyst composition, a method for hydrogenating a substrate molecule and a reaction mixture.
    Type: Grant
    Filed: August 23, 2016
    Date of Patent: September 12, 2017
    Assignee: DEXLECHEM GMBH
    Inventor: Sonja Jost
  • Patent number: 9475777
    Abstract: Porous partially fluorinated materials which bind aliphatic and aromatic hydrocarbons, fluorocarbons and freons with high weight adsorption capacities are provided. Such compounds may be used in separation of materials by exclusion such as selective separation of isomers of xylene.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: October 25, 2016
    Assignee: UNIVERSITY OF HOUSTON SYSTEM
    Inventors: Ognjen {hacek over (S)} Miljanić, Teng-Hao Chen, Ilya Popov, Watchareeya Kaveevivitchai, Olafs Daugulis
  • Patent number: 9346741
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: May 24, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Publication number: 20150129849
    Abstract: A compound having the structure of Formula 1, as well as, a first device and a formulation including the same are disclosed. In the structure of Formula 1: R5 is and (a) at least one of R1-R4 is or (b) R1 is In addition, R1, R2, R3, R4, A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, Y1, Y2, Y3, Y4, Y5, Y6, Y7, Y8, Z1, Z2, Z3, Z4, Z5, Z6, Z7, and Z8, are each independently selected from a variety of substituents, where adjacent A, B, Y, and Z groups are, optionally, joined to form a fused ring structure. Finally, X includes an acceptor group selected from —CmF2m+1, —SimF2m+1, —NCO, —NCS, —OCN, —SCN, —OCmF2m+1, and —SCmF2m+1.
    Type: Application
    Filed: August 20, 2014
    Publication date: May 14, 2015
    Inventors: Raymond Kwong, Siu Tung Lam, Chi Hang Lee
  • Patent number: 9018419
    Abstract: A library of macrocyclic compounds of the formula (I) where part (A) is a ?bivalent radical, a —(CH2)y— bivalent radical or a covalent bond; where part (B) is a ?bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond; where part (C) is a ?bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; and where part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.
    Type: Grant
    Filed: August 26, 2011
    Date of Patent: April 28, 2015
    Assignee: Ocera Therapeutics, Inc.
    Inventors: Pierre Deslongchamps, Yves Dory, Gilles Berthiaume, Luc Ouellet, Ruoxi Lan
  • Publication number: 20150097146
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: December 15, 2014
    Publication date: April 9, 2015
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 8993805
    Abstract: A novel material having high hole-transporting ability and a high glass transition temperature and having long-lasting durability is obtained. A benzofluorene compound represented by formula (1) is used. (In the formula, M is a substituted or unsubstituted aryl group having 6-40 carbon atoms or a substituted or unsubstituted heteroaryl group having 5-40 carbon atoms; Ar1 to Ar4 each independently is a substituted or unsubstituted aryl group having 6-40 carbon atoms or a substituted or unsubstituted heteroaryl group having 5-40 carbon atoms, provided that at least one of Ar1 to Ar4 is a substituent represented by any of the following formulae (2) to (5); and p is an integer of 0-2.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: March 31, 2015
    Assignee: Tosoh Corporation
    Inventors: Masakazu Nishiyama, Naoki Matsumoto, Takanori Miyazaki, Takeshi Kanbara
  • Patent number: 8993806
    Abstract: Porous bulk materials formed of shape-persistent, non-collapsible, three-dimensional molecular cage building blocks are presented that are useful for a variety of applications including gas separation/storage, sensing, and catalysis.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: March 31, 2015
    Assignee: The Regents of the University of Colorado, a body Corporate
    Inventors: Wei Zhang, Richard D. Noble, Yinghua Jin, Bret A. Voss
  • Publication number: 20150083223
    Abstract: A fullerene derivative represented by the following formula (1): wherein “FLN” represents a fullerene core, R1 represents an optionally substituted C1-C24 alkyl group or an optionally substituted C7-C24 aralkyl group, R2 and R3 independently represent a hydrogen atom or an optionally substituted C1-C24 hydrocarbon group but excluding a case where both of R2 and R3 are hydrogen atoms, and R2 and R3 may combine together to form a ring.
    Type: Application
    Filed: September 25, 2013
    Publication date: March 26, 2015
    Applicants: Tohoku University, Showa Denko K.K.
    Inventors: Tienan JIN, Weili Si, Yoshinori Yamamoto, Takeshi Igarashi
  • Patent number: 8987515
    Abstract: Radical initiated reactions of phenylenediamines with alkylated aromatic amines produce an antioxidant mixture containing cross reaction products of the phenylenediamines and alkylated aromatic amines which are useful, for example, as antioxidants, stabilizers, and antiozonants for lubricants, electronic chemicals, rubbers, urethanes and other polymer resins, crop protection, pharmaceuticals, dyes and toners.
    Type: Grant
    Filed: November 20, 2012
    Date of Patent: March 24, 2015
    Assignee: Chemtura Corporation
    Inventor: Robert G. Rowland
  • Publication number: 20150072984
    Abstract: Chemical entities that are curcumin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Application
    Filed: August 29, 2012
    Publication date: March 12, 2015
    Inventor: Xiangping Qian
  • Patent number: 8962890
    Abstract: Multifunctional amine crosslinkers that may be used to create crosslinked polyimide, polyamide, and poly(amide-imide) polymers and films having shape memory properties at elevated temperatures and methods of making the same.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: February 24, 2015
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, David Huabin Wang
  • Patent number: 8951549
    Abstract: The invention relates to a method for reducing the concentration of amines and salts thereof, wherein the amines have the general chemical formula I R1R2R3N and the salts have the formula II R1R2R3N—H, wherein the amines and salts thereof exist in aqueous solution or aqueous suspension and are brought into contact with clinoptilolitic or clinoptilolite-containing mixtures. The method itself is suitable for use in food preparation and in the manufacture of foods. The inventive idea of reducing the concentration of amines and salts thereof is also useful in the manufacture of medical products for absorbing and for removing amines from the intestinal tract or the skin area of humans and animals.
    Type: Grant
    Filed: November 16, 2009
    Date of Patent: February 10, 2015
    Assignee: Froximun AG
    Inventors: Günter Steimecke, Steffen Hoffmann, Thomas Görner
  • Publication number: 20150038574
    Abstract: Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: November 29, 2012
    Publication date: February 5, 2015
    Applicant: Bikam Pharmaceuticals, Inc.
    Inventors: David S. Garvey, Judd Berman, Tan Quach
  • Publication number: 20150018548
    Abstract: A process for producing N-methyl or N,N-dimethyl amines, which comprises using amine compound, nitro-containing compound or nitrile compound as a starting material, carbon dioxide as a methylating agent and hydrogen gas as a reducing agent, and allowing them to react in a sealed reactor for 6 to 48 h in a reaction medium at a reaction temperature of 80 to 180 ° C. in the presence of a composite catalyst, so as to provide N-methyl or N,N-dimethyl amines. The process of the present invention is simple and under relative mild reaction conditions. By means of the process of the invention, the target products can be prepared at low cost with a high yield. The catalysts used have a high catalytic activity and can be separated from the reaction system simply and reused. Furthermore, the whole process of the present invention is environmental-friendly and facilitates the cycling use of carbon dioxide.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 15, 2015
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Feng SHI, Xinjiang Cui, Hangkong Yuan, Yan Zhang, Youquan Deng
  • Publication number: 20140371418
    Abstract: The invention generally relates to biological engineering of microorganisms and production of chemical compounds therefrom. More particularly, the invention relates to novel genetically engineered microorganisms for the fermentative production of p-aminobenzoic acid and related compounds from fermentable carbon substrates. The biologically derived PABA and related compounds from fermentable carbon substrates can be used in a number of applications including as a food supplement or raw materials for the syntheses of other industrial chemicals or polymers.
    Type: Application
    Filed: January 4, 2013
    Publication date: December 18, 2014
    Applicant: pAromatics, LLC
    Inventors: Wing On Ng, Shingo Watanabe, Robert W.R. Humphreys, Steven C. Slater
  • Patent number: 8901353
    Abstract: To provide a novel diamine which is useful as the starting material of a novel polyimide precursor or polyimide which can provide a liquid crystal alignment film having a low volume resistivity, a liquid crystal aligning agent containing these polymers, and a liquid crystal alignment film.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: December 2, 2014
    Assignee: Nissan Chemical Industries, Ltd.
    Inventor: Masato Nagao
  • Publication number: 20140316130
    Abstract: This invention relates to the miniaturisation of radiosyntheses onto microfabricated devices, and in particular to use of microfabricated devices for radiosynthesis, isolation, and analysis of radiotracers for use in Positron Emission Tomography (PET).
    Type: Application
    Filed: April 15, 2014
    Publication date: October 23, 2014
    Applicant: HAMMERSMITH IMANET LIMITED
    Inventors: FRANK BRADY, SAJINDER KAUR LUTHRA, JAMES MILLAR GILLIES, NICHOLAS TOBY JEFFREY
  • Patent number: 8865219
    Abstract: The invention concerns coated granules including (A) at least one amine-containing pharmacological active principle, preferably as an acid addition salt, the pharmacological active principle being complexed by low cation-exchange resin containing carboxylic acid groups (COO?), and (B) at least 15 wt. %, based on the total weight of the active principle/low cation-exchange resin complex, of at least one hydrophilic adsorbent, the mixture of the components (A) and (B) being coated with a gastrosoluble polymer. The invention also concerns a method for preparing such granules, as well as orodispesible tablets containing such granules.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: October 21, 2014
    Assignee: Ethypharm
    Inventors: Mahendra B. Chaudhari, Edouard Gendrot
  • Publication number: 20140309459
    Abstract: Present invention relates to a method of preparing a chiral ?- or ?-substituted ketone from the corresponding ?- or ?-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula (II), (IV) or (VI), respectively, the method comprising reacting the aldehyde of formula (II), (IV) or (VI) in the presence of an amine, oxygen and an organic solvent, wherein the reaction is carried out in the absence of a metal-based catalyst or a metal-based oxidant, wherein: R is H, a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C15 alkenyl, substituted or unsubstituted C2-C15 alkynyl, substituted or unsubstituted C3-C15 cycloalkyl, substituted or unsubstituted C3-C15 cycloalkenyl, substituted or unsubstituted C3-C15 heterocycloalkyl, substituted or unsubstituted C3-C15 heterocycloalkenyl, substituted or unsubstituted C6-C15 aryl, or substituted or unsubstituted C6-C15 heteroaryl; and R? is H, a substituted or unsubstituted C1-C10 alkyl, substitut
    Type: Application
    Filed: December 13, 2012
    Publication date: October 16, 2014
    Inventors: Yonggui Chi, Bhoopendra Tiwari
  • Patent number: 8859817
    Abstract: Provided are a process for the preparation of phenyl carbamate derivatives, useful in the treatment of CNS (central nervous system) disorders, an intermediate in the synthesis of the phenyl carbamate derivatives, and a process for preparation of the intermediate.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: October 14, 2014
    Assignee: Bio-Pharm Solutions Co., Ltd.
    Inventor: Yong Moon Choi
  • Publication number: 20140275603
    Abstract: A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.
    Type: Application
    Filed: March 26, 2012
    Publication date: September 18, 2014
    Applicant: ANGUS Chemical Company
    Inventors: Raymond J. Swedo, George David Green, Charles E. Coburn
  • Publication number: 20140255847
    Abstract: A resist overlayer film composition for lithography from which a resist overlayer film is formed. A resist overlayer film forming composition including a benzene compound having at least one amino group. A resist may be an EUV resist or an electron beam resist. The benzene compound may have at least one amino group and at least one alkyl group, one or two amino groups and one to four alkyl groups, or may be a compound of Formula (1): where R1 to R5 are independently a hydrogen atom, a C1-10 alkyl group such as methyl, ethyl or isopropyl, or an amino group.
    Type: Application
    Filed: September 26, 2012
    Publication date: September 11, 2014
    Inventors: Ryuji Ohnishi, Takafumi Endo, Rikimaru Sakamoto
  • Patent number: 8822633
    Abstract: Luminescent polymers having sterically twisted arylene repeat units are provided, which are particularly suited as electroluminescent polymers. Monomers necessary for the synthesis of the sterically twisted polyarylene are provided, as are electroluminescent device utilizing these polymers.
    Type: Grant
    Filed: February 22, 2006
    Date of Patent: September 2, 2014
    Assignee: Sumitomo Chemical Co., Ltd.
    Inventors: Matthew L. Marrocco, Virgil J. Lee, Farshad J. Motamedi
  • Publication number: 20140228588
    Abstract: An object of the present invention is to provide a novel fungicide having an excellent fungicidal activity. The compound used as the fungicide of the present invention is an ethynylphenylamidine compound or a salt thereof, the compound being represented by Formula (1): wherein R1 and R2 are each hydrogen or C1-12 alkyl, or R1 and R2 may be bonded together to form C1-7 alkylene; R3 is hydrogen or C1-4 alkylthio; R4, R5, R6, and R7 are each hydrogen, halogen, etc.; and R8 is hydrogen, C1-20 alkyl, C3-8 cycloalkyl, C1-4 haloalkyl, phenyl, a heterocyclic group, or —(CH2)n-Si(R9)(R10)(R11) wherein R9, R10, and R11 are each C1-6 alkyl, and n is an integer of 0 or 1.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 14, 2014
    Applicant: OTSUKA AGRITECHNO CO., LTD.
    Inventors: Satoru Masumoto, Hitoshi Mutsutani, Sachi Kimura
  • Publication number: 20140228443
    Abstract: Provided are compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
    Type: Application
    Filed: February 7, 2014
    Publication date: August 14, 2014
    Applicant: Acucela Inc.
    Inventors: Ian L. Scott, Vladimir A. Kuksa, Feng Hong, Ryo Kubota, Jennifer Gage
  • Patent number: 8796489
    Abstract: The present disclosure relates to ketobenzofuran derivatives of the general formula (I): as well as to a method of synthesizing the same by coupling a quinonimine and an enaminone by a Nenitzescu reaction and to the intermediates of the synthesis thereof.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: August 5, 2014
    Assignee: Sanofi
    Inventors: Frédéric Bailly, Bernard Grimaud, Irina Malejonock, Philippe Vayron
  • Patent number: 8791300
    Abstract: Compounds of the formula II can be hydrogenated to the corresponding butane derivatives in the presence of homogeneous cataslysts composed of metal salts or complexes containing metals selected from the group consisting of Rh, Ir, and Ru and preferably containing diphosphine ligands, with, in addition, excellent optical yields being achieved when one of R2 and R3 is not a hydrogen atom and the diphosphine ligand is chiral.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: July 29, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Wolfgang Hell, Markus Kegel, Helmut Buschmann, Felix Spindler, Detlef Heller, Hans-Joachin Drexler
  • Patent number: 8785589
    Abstract: Cross-linked polyimides based on a novel crosslinker and methods of making the same. The general structure of these heat-resistant and amorphous polyimides is shown as follows: in which n, m, and l denote the degrees of polymerization (DP) of each arm and the linking group R? is one of the following moieties: —C(CF3)2—, —O—, —SO2—, >C(?O), —OPh-C(CH3)2-PhO-, -(Ph)C(CF3)—, or a direct bond (—). Films (cantilevers) comprising cross-linked polyimides according to the present invention demonstrate photodirected bending upon exposure to linearly polarized light.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: July 22, 2014
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, David Huabin Wang, Kyung Min Lee, Timothy J. White
  • Publication number: 20140200369
    Abstract: The present invention relates to an apparatus of the loop Venturi reactor type for the continuous reaction of liquids with gases, in particular for hydrogenations, oxidations or acetylations, e.g. for the preparation of toluenediamine by hydrogenation of dinitrotoluene, and a process for the continuous reaction of liquid reactants with gaseous reactants in the apparatus. In the apparatus of the invention, the diversion of an internal circulatory flow in the reactor is effected by means of a diversion pan which is arranged underneath a heat exchanger.
    Type: Application
    Filed: January 6, 2014
    Publication date: July 17, 2014
    Applicant: BASF SE
    Inventors: Oliver BEY, Christian KUNKELMANN, Roland BAUER, Andreas RAICHLE, Hartmut RIECHERS, Peter ZEHNER
  • Patent number: 8779202
    Abstract: Methods of treating exposure to Giardia lamblia and/or giardiasis and methods of antagonizing Giardia lamblia attachment to the intestinal wall of a subject are described herein.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: July 15, 2014
    Assignee: Georgetown University
    Inventors: Heidi G. Elmendorf, Colleen D. Walls, Christian Wolf
  • Patent number: 8766006
    Abstract: The present invention relates to the use of a nitroaniline derivative of Formula I for the production of nitric oxide and for the preparation of a medicament for the treatment of a disease wherein the administration of nitric oxide is beneficial. The present invention furthermore relates to a method for the production of NO irradiating a nitroaniline derivative of Formula I, a kit comprising a nitroaniline derivative of Formula I and a carrier and to a system comprising a source of radiations and a container associated to a nitroaniline derivative of Formula I. In Formula I, R and RI are each independently hydrogen or a C1-C3 alkyl group; RII is hydrogen or an alkyl group.
    Type: Grant
    Filed: April 8, 2013
    Date of Patent: July 1, 2014
    Assignee: STMicroelectronics S.r.l.
    Inventors: Sabrina Conoci, Salvatore Petralia, Salvatore Sortino
  • Patent number: 8766001
    Abstract: The present invention relates to the improvement in organic electroluminescent devices by using compounds of the formula (1), in particular as hole-injection or hole-transport materials in a hole-injection or hole-transport layer.
    Type: Grant
    Filed: March 5, 2009
    Date of Patent: July 1, 2014
    Assignee: Merck Patent GmbH
    Inventors: Christof Pflumm, Arne Buesing, Amir Hossain Parham, Rocco Fortte, Holger Heil, Philipp Stoessel
  • Publication number: 20140171687
    Abstract: Provided is a method for producing a 2-alkenylamine compound efficiently and at low cost, using a primary or secondary amine compound and a 2-alkenyl compound as the starting materials therefor. The 2-alkenylamine compound is produced by adding Bronsted acid when 2-alkenylating by reacting the primary or secondary amine compound with the 2-alkenyl compound, and 2-alkenylating in the presence of a catalyst comprising a complexing agent and a transition metal precursor stabilized by a monovalent anionic five-membered conjugated diene.
    Type: Application
    Filed: August 29, 2012
    Publication date: June 19, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY, SHOWA DENKO K.K.
    Inventors: Yoshitaka Ishibashi, Naoya Fukumoto, Masato Kitamura
  • Patent number: 8741809
    Abstract: The present invention relates to a novel liquid formulation for crop protection which comprises a) pyraclostrobin; b) at least one organic solvent S1 with a water solubility of less than 2 g/l at 20° C.; c) at least one organic solvent S2 with a water solubility of at least 2 g/l at 20° C., where S2 comprises at least one solvent S2.1 with a water solubility of more than 200 g/l at 20° C. and optionally at least one solvent S2.2 with a water solubility of 2 to 200 g/l at 20° C.; d) at least one anionic surface-active substance SA1; e) at least one nonionic surface-active substance SA2; and f) water. The invention also relates to the use of the crop protection formulation for treatment of plants and seed, and to corresponding methods.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: June 3, 2014
    Assignee: BASF SE
    Inventors: Ulrike Troppmann, Wolfgang Meier, Guenter Oetter, Ulrich Steinbrenner, Tatjana Levy, Jurith Montag, Tanja Brunner, Reiner Weiler
  • Patent number: 8735626
    Abstract: A method of producing an aromatic amino compound using a primary or secondary amine compound and a halogenated aromatic compound as starting materials, and relying upon the Ullmann reaction, the method being capable of obtaining the highly pure aromatic amino compound in high yields and inexpensively. A primary or secondary amine compound having an aromatic ring group and a halogenated aromatic compound as starting materials, are reacted with the halogenated aromatic compound in the presence of copper catalyst and base to produce the aromatic amino compound having a structure in which an aromatic ring group derived from the halogenated aromatic compound is coupled to the amino group of the amine compound, wherein the amine compound and the halogenated aromatic compound are reacted together such that an aromatic oxycarboxylic acid having a hydroxyl group and a hydroxycarbonyl group bonded to neighboring carbon atoms, is present together with the copper catalyst and the base.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: May 27, 2014
    Assignee: Hodogaya Chemical Co., Ltd.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi
  • Publication number: 20140131275
    Abstract: The present invention relates to a device for separating two immiscible phases and/or for extracting one phase with another phase (phase separation or extraction device), comprising at least one vessel for receiving the at least two phases, at least one pipe for supplying a fluid to the vessel, at least one pipe for discharging a fluid from the vessel, and at least one arrangement comprising a transparent disk for observing the separation operation or the extraction operation, wherein at least the side of the transparent disk that faces the phases to be separated or extracted consists of sapphire (sapphire glass) or mica ( mica disk), and to the use of such a device in the preparation of di- and polyamines of the diphenylmethane series.
    Type: Application
    Filed: November 15, 2012
    Publication date: May 15, 2014
    Applicants: Bayer Intellectual Property GmbH, Bayer MaterialScience LLC
    Inventors: Bodo Temme, Stefan Wershofen, Thomas Knauf, Richard Adamson, Wolfgang Paura, Bernd Fruhen, Susan Dadd, Ralf Esser
  • Patent number: 8722881
    Abstract: A tetradendate amide based macrocyclic ligand and its Fe(III) complex which act as activators of hydrogen peroxide. The synthetic methodology to develop the ligands is new, simple and provides better yield for each step of the ligand synthesis. The Fe(III)-complexes and hydrogen peroxide together are can perform several environmentally benign oxidation reactions. Organic dye bleaching, bleaching of pulp and paper effluent and N-oxide synthesis may be performed using the newly developed catalyst and hydrogen peroxide. Alcohol oxidation and alkene epoxidation may also be performed using the catalysts and hydrogen peroxide.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: May 13, 2014
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Anindya Ghosh, Shane Z. Sullivan, Samuel L. Collom, Sharon Pulla
  • Patent number: 8680336
    Abstract: Dyes for dye-sensitized solar cell are provided. Each of the dyes for a dye-sensitized solar cell according to an embodiment has a chemical structure: wherein each of X and Y may comprise a substituent, comprising aromatic hydrocarbon groups which are respectively independently substituted or unsubstituted, aromatic heterocyclic groups which are substituted or unsubstituted, and a combination thereof, Z may comprise aromatic hydrocarbon groups which are substituted or unsubstituted, heterocyclic groups which are substituted or unsubstituted, vinyl groups, and polyvinyl groups which are substituted or unsubstituted, and A may comprise acid functional groups.
    Type: Grant
    Filed: September 16, 2009
    Date of Patent: March 25, 2014
    Assignee: LG Display Co., Ltd.
    Inventors: Jonghyun Park, Seongkee Park, Sunghoon Joo, Jinok Hwang, Taeyoun Kim
  • Publication number: 20140080916
    Abstract: Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods for treatment, inhibition, and/or abatement of cognitive decline and/or Alzheimer's disease with a compound or pharmaceutically acceptable salt of the invention are also provided. Also provided are methods of preparing the compounds/compositions of the invention.
    Type: Application
    Filed: February 1, 2012
    Publication date: March 20, 2014
    Applicant: Cognition Therapeutics, Inc.
    Inventors: Gilbert M. Rishton, Susan Catalano
  • Patent number: 8669399
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: March 11, 2014
    Assignee: Grünenthal GmbH
    Inventors: Helmut Heinrich Buschmann, Joerg Holenz
  • Patent number: 8664276
    Abstract: Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. Such stilbene analogs include, for example, compounds of the following formula: wherein Ra, Rb, R4, R6, R7, R9 and R10 are all H; R2 and R3 are independently H, halo, amino, alkylamino, dialkylamino, N-oxides of dialkylamino, arylalkylamino, trialkylammonium, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONR11R12, NR11CO(R13), NR11COO(R13) or NR11CONR12R13; R11, R12 and R13, are independently, H, alkyl, aryl, heteroaryl or a fluorine; R8 is NRCRdZ wherein Rc is H, alkyl, alkoxy, aryl or heteroaryl, Rd is an alkyl group, Z is a an unshared pair of electrons, H, alkyl or oxygen; and R1 and R5 are halogen.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: March 4, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: David Watt, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang
  • Patent number: 8664442
    Abstract: A dialkylanilino-cyclohexane compound useful as an antioxidant has the following formula I or formula II: wherein Ar1 and Ar2 can be the same or different and each is an alkylaromatic group; each of R1, R2, R3, and R4 is independently selected from hydrogen or CR7R8; each of R5, R6, and R7 is independently selected from hydrogen and a substituted or unsubstituted C1 to C32 hydrocarbyl group; and each R8 is independently selected from hydrogen and a C1 to C2 alkyl group, provided that when, each of R1 and R2 is CR7R8 and each such R8 is other than hydrogen, R1 and R2 may be joined to form a five or six-membered ring, and provided further that when, each of R3 and R4 is an adjacent CR7R8 and each such R8 is other than hydrogen, R3 and R4 may be joined to form a five or six-membered ring.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: March 4, 2014
    Assignee: Chemtura Corporation
    Inventor: Theodore E. Nalesnik
  • Patent number: 8664443
    Abstract: The present invention relates to an improved process for the preparation of (1S,3S,5S)-2-[2(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and its intermediates.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: March 4, 2014
    Assignee: Divi's Laboratories Ltd.
    Inventors: Murali Krishna Prasad Divi, Gundu Rao Padakandla, Nageswara Rao Bolneni, Gopinarayana Bodala
  • Publication number: 20140058101
    Abstract: The invention is directed to a phosphine compound represented by general formula (1) wherein R? and R? independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R? and R? are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cps is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. Also claimed is the use of these phosphines as ligands in catalytic reactions and the preparation of these phosphines.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: Evonik Degussa GmbH
    Inventors: Herbert Plenio, Christoph Fleckenstein, Renat Kadyrov, Juan Almena, Axel Monsees, Thomas Riermeier
  • Publication number: 20140058091
    Abstract: Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes removing at least a portion of mercury containing compounds from a hydrocarbon stream. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to another hydrocarbon process. The method according to certain aspects includes controlling the level of organic, ionic or suspended mercury compounds by first converting these compounds to elemental mercury or to inorganic mercury compounds and then removing them by use of an adsorbent bed.
    Type: Application
    Filed: July 25, 2013
    Publication date: February 27, 2014
    Applicant: UOP LLC
    Inventors: Dean E. Rende, Jayant K. Gorawara
  • Publication number: 20140058088
    Abstract: Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes removing at least a portion of hydrides of arsenic, phosphorus, antimony, silicon, and boron from a hydrocarbon stream. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to another hydrocarbon process. The method according to certain aspects includes controlling the level of hydrides of arsenic, phosphorus, antimony, silicon, and boron in the hydrocarbon stream.
    Type: Application
    Filed: July 25, 2013
    Publication date: February 27, 2014
    Applicant: UOP LLC
    Inventors: Dean E. Rende, Jayant K. Gorawara, Peter K. Coughlin
  • Publication number: 20140058089
    Abstract: Methods and systems are provided for converting methane in a feed stream to acetylene. The method includes removing at least a portion of sulfur containing compounds from a hydrocarbon stream. The hydrocarbon stream is introduced into a supersonic reactor and pyrolyzed to convert at least a portion of the methane to acetylene. The reactor effluent stream may be treated to convert acetylene to another hydrocarbon process. The method according to certain aspects includes controlling the level of sulfur containing compounds in the hydrocarbon stream.
    Type: Application
    Filed: July 25, 2013
    Publication date: February 27, 2014
    Applicant: UOP LLC
    Inventors: Dean E. Rende, Jayant K. Gorawara, Laura E. Leonard