Benzophenones Or Benzothiophenones (i.e., The Carbon Is Part Of A Carbonyl Or Thiocarbonyl) Patents (Class 564/328)
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Publication number: 20150105565Abstract: The present invention provides novel photoinitiators for polyurethane formation, in which a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure, and thus the polyurethane polymer.Type: ApplicationFiled: December 19, 2014Publication date: April 16, 2015Inventors: Niels Joergen Madsen, Petr Sehnal, Christian B. Nielsen, David George Anderson
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Patent number: 8906979Abstract: The invention pertains to high-molecular photoinitiator compounds comprising a photoactive moiety Q and an amine functionality, preferably a tertiary amino group, where the photoactive moiety Q is a benzoyl photoactive moiety.Type: GrantFiled: July 26, 2010Date of Patent: December 9, 2014Assignee: BASF SEInventors: Markus Frey, Christophe Frossard, Katia Studer, Bruno Spony, Patrizia Sgambati
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Publication number: 20130316985Abstract: A pharmaceutical composition including at least one compound of the Formulas (I), (II), or (III), or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, as defined herein. Also disclosed is a method of treatment of diseases which are pathophysiologically related to GPR35, the GPR35-hERG signaling complex, or both, as defined herein.Type: ApplicationFiled: May 20, 2013Publication date: November 28, 2013Applicant: Corning IncorporatedInventors: Huayun Deng, Ye Fang
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Publication number: 20130296577Abstract: Novel photoinitiators provide for polyurethane formation, in which a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure, and thus the polyurethane polymer.Type: ApplicationFiled: November 11, 2011Publication date: November 7, 2013Applicant: Coloplast A/SInventors: Niels Joergen Madsen, Petr Sehnal, Christian B. Nielsen, David George Anderson
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Patent number: 8389769Abstract: A polymerizable Type II photoinitiator according to Formula (I): wherein: A represents a Norrish Type II initiating group; L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-8 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 8 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: GrantFiled: May 28, 2009Date of Patent: March 5, 2013Assignee: Agfa Graphics NVInventors: Johan Loccufier, Jaymes Van Luppen
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Patent number: 8362101Abstract: A multifunctional Type II photoinitiator according to Formula (I): wherein X represents a structural moiety according to Formula (II): wherein: A represents a Norrish Type II initiating group; and L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-9 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 9 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: GrantFiled: May 28, 2009Date of Patent: January 29, 2013Assignee: Agfa Graphics NVInventors: Johan Loccufier, Jaymes Van Luppen
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Publication number: 20120178844Abstract: The invention pertains to high-molecular photoinitiator compounds comprising a photoactive moiety Q and an amine functionality, preferably a tertiary amino group, where the photoactive moiety Q is a benzoyl photoactive moiety.Type: ApplicationFiled: July 26, 2010Publication date: July 12, 2012Applicant: BASF SEInventors: Markus Frey, Christophe Frossard, Katia Studer, Bruno Spony, Patrizia Sgambati
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Publication number: 20110216392Abstract: The present invention relates to the preparation and use of (colored) organic particles carrying electric charge as electrophoretic (image) displaying particles, to electrophoretic dispersions comprising the organic particles carrying electric charge, electrophoretic (image) devices (especially displays) comprising the colored organic particles carrying electric charge, to the novel functionalized particles, and to their use. The particles are obtainable according to a method represented by the reaction scheme as given in FIG. 1.Type: ApplicationFiled: June 25, 2007Publication date: September 8, 2011Inventors: Gabriele Baisch, Reinhold Öhrlein, Peter Simmendinger, Gerardus De Keyzer, Margherita Fontana, Vilas N. Mumbaikar
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Publication number: 20110069130Abstract: A multifunctional Type II photoinitiator according to Formula (I): wherein X represents a structural moiety according to Formula (II): wherein: A represents a Norrish Type II initiating group; and L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-9 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 9 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: ApplicationFiled: May 28, 2009Publication date: March 24, 2011Applicant: AGFA GRAPHICS NVInventors: Johan Loccufier, Jaymes Van Luppen
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Patent number: 7906682Abstract: This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desirable because they are soluble in aromatic solvents.Type: GrantFiled: January 13, 2010Date of Patent: March 15, 2011Assignee: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wen-Liang Hsu
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Patent number: 7671237Abstract: This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desirable because they are soluble in aromatic solvents.Type: GrantFiled: June 30, 2006Date of Patent: March 2, 2010Assignee: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wen-Liang Hsu
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Patent number: 7642367Abstract: The invention provides novel diamino-functionalized chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.Type: GrantFiled: May 19, 2003Date of Patent: January 5, 2010Assignee: Lica Pharmaceuticals A/SInventors: Simon Feldbæk Nielsen, Kristian Schønning, Hasse Kromann, Thomas Boesen, Mogens Larsen
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Patent number: 7045366Abstract: Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.Type: GrantFiled: March 17, 2004Date of Patent: May 16, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: Wenxi Huang, Pil-je Um
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Patent number: 7034015Abstract: The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating patients comprising administering said compounds, and to the use of said compounds in the manufacture of pharmaceutical preparations.Type: GrantFiled: August 28, 2002Date of Patent: April 25, 2006Assignee: Leo Pharma A/SInventors: Erik Rytter Ottosen, Anne Marie Horneman, Xifu Liang
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Patent number: 6841681Abstract: 2-Cyclopropyl-4-(4?-fluorophenyl)quinoline-3-carboxyaldehyde useful as a material for pharmaceutical products, can be obtained by reacting 3-cyclopropyl-3-oxopropanenitrile with 2-amino-4?-fluorobenzophenone to obtain 2-cyclopropyl-4-(4?-fluorophenyl)quinoline-3-carbonitrile, and reducing it.Type: GrantFiled: February 14, 2002Date of Patent: January 11, 2005Assignee: Nissan Chemical Industries, Ltd.Inventors: Katsumasa Harada, Shigeyoshi Nishino, Kenji Hirotsu, Hidetaka Shima, Naoko Okada, Takashi Harada, Akira Nakamura, Hiroyuki Oda
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Patent number: 6797841Abstract: Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.Type: GrantFiled: October 1, 2002Date of Patent: September 28, 2004Assignee: Albemarle CorporationInventors: John Gabriel Santobianco, Rajamani Nagarajan, August John Muller, Joseph Stanton Bowers, Jr.
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Patent number: 6781015Abstract: Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.Type: GrantFiled: October 1, 2002Date of Patent: August 24, 2004Assignee: Albemarle CorporationInventors: John Gabriel Santobianco, Rajamani Nagarajan, August John Muller, Joseph Stanton Bowers, Jr.
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Patent number: 6762323Abstract: Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.Type: GrantFiled: October 1, 2002Date of Patent: July 13, 2004Assignee: Albemarle CorporationInventors: John Gabriel Santobianco, Rajamani Nagarajan, August John Muller, Joseph Stanton Bowers, Jr.
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Publication number: 20040097634Abstract: This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desirable because they are soluble in aromatic solvents. The present invention more specifically discloses a process for synthesizing a dilithium initiator which comprises reacting diisopropenylbenzene with a tertiary alkyl lithium compound in an aromatic solvent at a temperature which is within the range of about 0° C. to about 100° C. The present invention further discloses a process for synthesizing m-di-(1-lithio-1-methyl-3,3-dimethylbutyl) benzene which comprises reacting diisopropenylbenzene with tertiary-butyllithium in an aromatic solvent at a temperature which is within the range of about 0° C. to about 100° C.Type: ApplicationFiled: November 14, 2003Publication date: May 20, 2004Applicant: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wen-Liang Hsu
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Patent number: 6686504Abstract: This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desirable because they are soluble in aromatic solvents. The present invention more specifically discloses a process for synthesizing a dilithium initiator which comprises reacting diisopropenylbenzene with a tertiary alkyl lithium compound in an aromatic solvent at a temperature which is within the range of about 0° C. to about 100° C. The present invention further discloses a process for synthesizing m-di-(1-lithio-1-methyl-3,3-dimethylbutyl)benzene which comprises reacting diisopropenylbenzene with tertiary-butyllithium in an aromatic solvent at a temperature which is within the range of about 0° C. to about 100° C.Type: GrantFiled: August 31, 2001Date of Patent: February 3, 2004Assignee: The Goodyear Tire & Rubber CompanyInventors: Adel Farhan Halasa, Wen-Liang Hsu
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Publication number: 20030229148Abstract: 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.Type: ApplicationFiled: April 8, 2003Publication date: December 11, 2003Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Nicola Fanto, Gian Piero Moretti, Piero Foresta
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Patent number: 6624199Abstract: The present invention relates to compounds of formula I wherein R1 represents one or more, similar or different substituents; R2 represents hydrogen, hydroxy, halogen, alkyl, alkoxy, alkylthio, or cyano; R3 represents one or more, similar or different substituents; and R6 represents hydrogen or methyl; and salts thereof with pharmaceutically acceptable acids, hydrates, and solvates, and to the use of compounds of the general formula II in which formula R1 and R2 independently represent one or more, similar or different substituents; R3 represents hydrogen, halogen, hydroxy, mercapto, trifluoromethyl, amino, alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, phenyl, cyano, carboxy, or carbamoyl; R4, R5 and R6 represent independently hydrogen, trifluoromethyl, alkyl, carbamoyl, alkoxycarbonyl, or alkaloyl; x represents oxygen, N—OH, and N—O-alkyl, dialkoxy, cyclic dialkoxy, dialkylthio, or cyclic dialkylthio, and salts thereof with pharmaceutically acceptablType: GrantFiled: February 22, 2002Date of Patent: September 23, 2003Assignee: Leo Pharmaceuticals Products Ltd. A/SInventors: Erik Rytter Ottosen, Fredrik Björkling
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Patent number: 6566554Abstract: The present invention relates to a compound of general formula (I) wherein R1, R2, and R3 represents one or more, same or different substituents selected from the group consisting of halogen, hydroxy, mercapto, trifluoromethyl, amino, (C1-C3)alkyl, (C2-C3)olefinic group, (C1-C3)alkoxy, (C1-C3)akylthio, (C1-C6)alkylamino, (C1-C3)alkoxycarbonyl, cyano, —CONH2, phenyl, or nitro; further R2 can be hydrogen, and R3 can be carboxy and carbamoyl; R4 represents hydrogen, (C1-C3)alkyl, or allyl; X represents oxygen or sulphur; Q represents —(CO)—, —(CS)—, or a bond; Y represents (C5-C15)alkyl; (C2-C15)olefinic group; (C3-C10)monocyclic hydrocarbon group; or phenyl; any of which may be optionally substituted by one or more, same or different substituents selected from the group consisting of the formula R5 defined below; (C1-C4)alkyl substituted by one or more substituents selected for the group R5; or a group of the formula —(Z—O)n—Z, wherein Z is a (C1-C3)alkyl, n is anType: GrantFiled: February 22, 2002Date of Patent: May 20, 2003Assignee: Leo Pharmaceutical Products Ltd. a/s (Lovens Kemiske Fabrik Produktionsaktieselskab)Inventor: Erik Rytter Ottosen
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Publication number: 20030073754Abstract: Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.Type: ApplicationFiled: October 1, 2002Publication date: April 17, 2003Applicant: Albemarle CorporationInventors: John Gabriel Santobianco, Rajamani Nagarajan, August John Muller, Joseph Stanton Bowers
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Publication number: 20030045725Abstract: A method for the production of substituted aromatic aldehydes or ketones and optionally substituted heteroaromatic aldehydes or ketones of formula (I) by reacting a compound of formula (II) in a suitable solvent in the presence of a carbonyl compound of formula (III), optionally in the presence of oxygen at a normal pressure or high temperature and at temperatures of 5-200° C.Type: ApplicationFiled: September 20, 2002Publication date: March 6, 2003Inventors: Wolfram Hendel, Ferdinand Heu, Peter Poechlauer, Berthold Winkler
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Publication number: 20020035294Abstract: This invention discloses a process for making dilithium initiators in high purity. This process can be conducted in the absence of amines which is desirable since amines can act as modifiers for anionic polymerizations. The dilithium compounds made are highly desirable because they are soluble in aromatic solvents. The present invention more specifically discloses a process for synthesizing a dilithium initiator which comprises reacting diisopropenylbenzene with a tertiary alkyl lithium compound in an aromatic solvent at a temperature which is within the range of about 0° C. to about 100° C. The present invention further discloses a process for synthesizing m-di-(1-lithio-1-methyl-3,3-dimethylbutyl)benzene which comprises reacting diisopropenylbenzene with tertiary-butyllithium in an aromatic solvent at a temperature which is within the range of about 0° C. to about 100° C.Type: ApplicationFiled: August 31, 2001Publication date: March 21, 2002Inventors: Adel Farhan Halasa, Wen-Liang Hsu
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Patent number: 6310249Abstract: A 2-aminobenzophenone represented by formula (2) is obtained by heating an arylsulfonamide represented by formula (1) in the presence of aluminum chloride.Type: GrantFiled: January 22, 2001Date of Patent: October 30, 2001Assignee: Nissan Chemical Industries, Ltd.Inventors: Hiroo Matsumoto, Takashi Horiuchi
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Patent number: 6303821Abstract: The present invention relates to rubber compounds containing aromatic ketone polysulfides of the formula: wherein R is selected from the group consisting of alkyls having from 1 to 18 carbon atoms and x is an integer of from 2 to 8.Type: GrantFiled: November 11, 1999Date of Patent: October 16, 2001Assignee: The Goodyear Tire & Rubber CompanyInventors: Lawson Gibson Wideman, Shingo Futamura
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Publication number: 20010003749Abstract: A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for alleviating the symptoms of nicotine and tobacco withdrawal.Type: ApplicationFiled: January 3, 2001Publication date: June 14, 2001Inventors: Alexander Glenn Godfrey, Daniel Timothy Kohlman, John Cunningham O'Toole, Yao-Chang Xu, Tony Yantao Zhang
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Patent number: 6156902Abstract: The invention relates to novel bis-o-aminophenols, and bis-o-aminothiophenols of the following structure: ##STR1## where A.sup.1 to A.sup.3 are--independently of one another--H, CH.sub.3, OCH.sub.3, CH.sub.2 CH.sub.3, or OCH.sub.2 CH.sub.3T is O or S, andZ is a carbocyclic or heterocyclic aromatic radical.Type: GrantFiled: September 24, 1998Date of Patent: December 5, 2000Assignee: Infineon Technologies AGInventors: Recai Sezi, Michael Keitmann, Andreas Weber
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Patent number: 6011178Abstract: 2-Amino-4,5,3',4'-tetramethoxybenzophenone of the formula: ##STR1## is prepared by mononitration of 3,3',4,4'-tetramethyoxybenzophenone using nitric acid in the presence of acetic acid, and subsequent reduction of the nitro group. The compound is an intermediate in the synthesis of active ingredients against rheumatoid arthritis.Type: GrantFiled: March 12, 1999Date of Patent: January 4, 2000Assignee: Lonza, Ltd.Inventors: Oleg Werbitzky, Walter Brieden, Etienne Heinzmann
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Patent number: 5986136Abstract: Disclosed is a compound represent by the following structural formula: ##STR1## X is --H or an amine protecting group; --OY is --OH, an activating group for a carboxylic acid or a protecting group for a carboxylic acid; Z is --H or a phenolic protecting group, with the proviso that Z is not a straight chained, unsaturated alkyl group such as, for example, methyl or ethyl, and at least one of X, Y or Z is not --H.Also disclosed is a photoreactive polypeptide having a polypeptide chain comprising a residue of the compound described above. Also disclosed is a method of labeling a target molecule which forms a complex with the photoreactive polypolypeptide by photolyzing the photoreactive polypeptide when complexed with the target molecule.Type: GrantFiled: April 9, 1998Date of Patent: November 16, 1999Assignee: President and Fellows of Harvard CollegeInventor: John E. Maggio
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Patent number: 5689004Abstract: Controlled molecular weight imide oligomers and co-oligomers containing pendent phenylethynyl groups (PEPIs) and endcapped with nonreactive or phenylethynyl groups have been prepared by the cyclodehydration of the precursor amide acid oligomers or co-oligomers containing pendent phenylethynyl groups and endcapped with nonreactive or phenylethynyl groups. The amine terminated amide acid oligomers or co-oligomers are prepared from the reaction of dianhydride(s) with an excess of diamine(s) and diamine containing pendent phenylethynyl groups and subsequently endcapped with a phenylethynyl phthalic anhydride or monofunctional anhydride. The anhydride terminated amide acid oligomers and co-oligomers are prepared from the reaction of diamine(s) and diamine containing pendent phenylethynyl group(s) with an excess of dianhydride(s) and subsequently endcapped with a phenylethynyl amine or monofunctional amine.Type: GrantFiled: November 12, 1996Date of Patent: November 18, 1997Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: John W. Connell, Joseph G. Smith, Jr., Paul M. Hergenrother
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Patent number: 5675039Abstract: Disclosed are bis-meta-benzotrifluoride compounds having the general formula ##STR1## where each A is independently selected from the group consisting of NO.sub.2, NH.sub.2, and NH.sub.3.sup.+ Z.sup.-, Z.sup.- is an anion and B is selected from the group consisting of O, CO, S, SO, and SO.sub.2. The diamine compounds are useful as monomers in making polyimides, polyamide-imides, and polyamides.Type: GrantFiled: April 15, 1996Date of Patent: October 7, 1997Inventors: Jeffrey S. Stults, Henry C. Lin, Robert A. Buchanan
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Patent number: 5625089Abstract: Anilines of the formula ##STR1## where rings A and B may each be benzofused,X is a bridge member,R.sup.1 and R.sup.2 are each hydrogen, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, halogen, hydroxysulfonyl, carboxyl, C.sub.1 -C.sub.4 -alkoxycarbonyl or C.sub.1 -C.sub.4 -alkylsulfonyl,R.sup.3 is hydrogen, amino, C.sub.1 -C.sub.4 -alkanoylamino or nitro, andY is vinyl or a radical of the formula C.sub.2 H.sub.4 --Q, where Q is a group detachable under alkaline reaction conditions.Type: GrantFiled: February 28, 1996Date of Patent: April 29, 1997Assignee: BASF AktiengesellschaftInventor: Manfred Patsch
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Patent number: 5599993Abstract: Four phenylethynyl amine compounds--3 and 4-aminophenoxy-4'-phenylethynylbenzophenone, and 3 and 4-amino-4'-phenylethynylbenzophenone--were readily prepared and were used to endcap imide oligomers. Phenylethynyl-terminated amide acid oligomers and phenylethynyl-terminated imide oligomers with various molecular weights and compositions were prepared and characterized. These oligomers were cured at 300.degree. C. to 400.degree. C. to provide crosslinked polyimides with excellent solvent resistance, high strength and modulus and good high temperature properties. Adhesive panels, composites, films and moldings from these phenylethynyl terminated imide oligomers gave excellent mechanical performance.Type: GrantFiled: January 20, 1995Date of Patent: February 4, 1997Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Paul M. Hergenrother, Robert G. Bryant, Brian J. Jensen, Stephen J. Havens
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Patent number: 5484880Abstract: The present invention relates to an amorphous polyimide or a polyimide copolymer having a requisite structural unit consisting of one or more recurring structural units represented by the formula (1): ##STR1## wherein X is a direct bond, oxygen atom or sulfur atom, and R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are individually a hydrogen atom or methyl, and Ar is a tetravalent radical having 6 to 27 carbon atoms and being selected from the group consisting of a monoaromatic radical, condensed polyaromatic radical and noncondensed polyaromatic radical having aromatic radicals connected to each other with a direct bond or a bridge member.Polyimide and the polyimide copolymer of the invention has excellent heat resistance, is outstanding in melt-flow stability, has greatly improved processability, and can be applied to structural materials, and electric- electronic appliances.Type: GrantFiled: December 13, 1994Date of Patent: January 16, 1996Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Wataru Yamashita, Yuichi Okawa, Shoji Tamai, Mitsunori Matsuo, Tsutomu Ishida, Keizaburo Yamaguchi, Akihiro Yamaguchi
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Patent number: 5411973Abstract: Compounds of formula I ##STR1## wherein X, A, B, R.sup.1 and R.sup.2 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable ester thereof, processes for preparing the compounds and pharmaceutical compositions comprising them. The compounds are useful as potassium channel openers and as therapeutic agents in the treatment of urinary incontinence.Type: GrantFiled: May 18, 1993Date of Patent: May 2, 1995Assignee: Zeneca LimitedInventors: Keith Russell, James R. Empfield, Cyrus J. Ohnmacht, Keith H. Gibson
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Patent number: 5410084Abstract: A polyimide comprising a requisite structural unit having one or more recurring structural units of the formula: ##STR1## such as the structural units of the formula ##STR2## Further, the present invention relates to a novel aromatic diamine which has a perfluoro radical and can be used as a raw material monomer of the polyimide, and a process for preparing the same.The polyimide can have an extremely low dielectric constant and is colorless, transparent and excellent in processability and heat resistance.Type: GrantFiled: June 2, 1994Date of Patent: April 25, 1995Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Mitsunori Matsuo, Tsutomu Ishida, Keizaburo Yamaguchi, Akihiro Yamaguchi
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Patent number: 5354890Abstract: A heat-resistant and thermoplastic polyimide which has low dielectric characteristics and recurring structural units of the following formula: ##STR1## wherein R is a tetravalent radical having from 2 to 27 carbon atoms and selected from the group consisting of an aliphatic radical, alicyclic radical, monoaromatic radical, condensed polyaromatic radical and noncondensed aromatic radical connected each other with a direct bond or a bridge member; aromatic diamines which are useful for the raw material monomers of the polyimide and have following formulas: ##STR2## and a process for preparing the polyimide of the above formula by reacting these aromatic diamines with a tetracarboxylic dianhydride in the presence of an aromatic dicarboxylic anhydride or aromatic monoamine, and successively thermally or chemically imidizing the resultant polyamic acid; are disclosed.Type: GrantFiled: June 24, 1993Date of Patent: October 11, 1994Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Shoji Tamai, Wataru Yamashita, Yuichi Okawa, Yuko Ishihara, Keizaburo Yamaguchi, Akihiro Yamaguchi
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Patent number: 5344986Abstract: Compounds of the formula: ##STR1## wherein: n=0 or 1;R.sub.1 and R.sub.2 are C.sub.1 to C.sub.3 alkyl groups, or R.sub.2 may be H when n=0; and Y is selected from the group: ##STR2## wherein: m=1-6Z=SO.sub.2, S, C=O, CH.sub.2 or C(CH.sub.3).sub.2 ; and a process for their preparation are described.Type: GrantFiled: March 7, 1991Date of Patent: September 6, 1994Assignee: Bromine Compounds, Ltd.Inventors: Jakob Oren, Joshua Hermolin, David Feldman, Michael Zviely, Dov Zamir, Hugo Keselman
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Patent number: 5344981Abstract: A new class of polymers is provided, as well as the monomers used for their preparation. The polymers provided in accordance with practice of the present invention include repeating units comprising one or more quinoline groups, wherein at least a portion of the repeating units includes a hexafluoroisopropylidene (6F) group or a 1-aryl-2,2,2-trifluoroethylidene (3F) group, or both.The hexafluoroisopropylidene group is referred to herein as a "6F" group and has the following structure: ##STR1## The "6F" group includes a tetravalent carbon atom bound to two trifluoromethyl moieties, with its other two bonds forming linkages in the polymer chain.The 1-aryl-2,2,2-trifluoroethylidene group is referred to herein as a "3F" group and has the following structure: ##STR2## wherein Ar' is an aryl group.Type: GrantFiled: July 28, 1993Date of Patent: September 6, 1994Assignee: Maxdem IncorporatedInventor: Neil H. Hendricks
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Patent number: 5286753Abstract: The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes, 3-aminochromanes, and 3-aminothiochromanes, including their corresponding sulfoxides and sulfones, which ring-substituted compounds exhibit agonist activity at the serotonin 1A receptor.Type: GrantFiled: April 16, 1993Date of Patent: February 15, 1994Assignee: Eli Lilly and CompanyInventors: John M. Schaus, Craig S. Hoechstetter, Diane Huser, Charles J. Paget, Robert D. Titus
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Patent number: 5153356Abstract: Aminobenzophenones have the formula ##STR1## where the ring A may be benzofused,X.sup.1 is hydrogen or hydroxysulfonyl,X.sup.2 is hydrogen, hydroxysulfonyl, hydroxysulfonylphenyl, hydroxysulfonylbenzyl or hydroxysulfonylphenylethyl,R.sup.1, R.sup.2 and R.sup.3 are each independently of the others hydrogen, halogen, C.sub.1 -C.sub.12 -alkyl, cyclohexyl or C.sub.1 -C.sub.4 -alkoxy, or one of them may also be the radical of the formula ##STR2## where L is a chemical bond, C.sub.1 -C.sub.4 -alkylene or --O--CH.sub.2 -- and Y.sup.1, Y.sup.2 and Y.sup.3 are each independently of the others hydrogen, halogen, C.sub.1 -C.sub.12 -alkyl or C.sub.1 -C.sub.4 -alkoxy and R.sup.4, X.sup.1, X.sup.2 and the ring A are each as defined above, andR.sup.4 is hydrogen or chlorine,with the proviso that X.sup.1 and X.sup.2 are not both hydrogen, their intermediates having the formula ##STR3## where L is as defined above.Type: GrantFiled: July 22, 1991Date of Patent: October 6, 1992Assignee: BASF AktiengesellschaftInventors: Gunther Lamm, Friedhelm Teich
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Patent number: 5145937Abstract: New polyimides have been prepared from the reaction of aromatic dianhydrides with novel aromatic diamines containing carbonyl and ether connecting groups between the aromatic rings. Several of these polyimides were shown to be semi-crystalline as evidenced by wide angle x-ray diffraction and differential scanning calorimetry. Most of the polyimides form tough solvent resistant films with high tensile properties. Several of these materials can be thermally processed to form solvent and base resistant moldings.Type: GrantFiled: November 9, 1989Date of Patent: September 8, 1992Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Paul M. Hergenrother, Stephen J. Havens
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Patent number: 5145953Abstract: A biscyclobutarene monomer is prepared having two cyclobutarene moieties bridged by a divalent radical having at least one azo linkage. The monomers can be polymerized to form polymers exhibiting outstanding thermooxidative stability at high temperatures for prolonged time periods.Type: GrantFiled: February 2, 1988Date of Patent: September 8, 1992Assignee: The Dow Chemical CompanyInventors: Robert A. Kirchhoff, Alan K. Schrock
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Patent number: 5145942Abstract: Novel polyimides have been prepared from the reaction of aromatic diahydrides with novel aromatic diamines having carbonyl and ether groups connecting aromatic rings containing pendant methyl groups. The methyl substituent polyimides exhibit good solubility and form tough, strong films. Upon exposure to ultraviolet irradiation and/or heat, the methyl substituted polyimides crosslink to become insoluble.Type: GrantFiled: September 28, 1990Date of Patent: September 8, 1992Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Paul M. Hergenrother, Stephen J. Havens
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Patent number: 5118839Abstract: A process for preparing nitro substituted polyarylketones of the formula: ##STR1## is disclosed. The process involves the condensation of ##STR2## where R.sub.A is hydrogen, --COOH, or C.sup.1 to C.sub.12 linear or branched alkyl, Y and Y' are the same or different and are a chemical bond ##STR3## or --Si(CH.sub.3).sub.2 -- and m is 0 or 1 and X is halo. These nitro groups of these compounds can be reduced to provide the corresponding amines, which are useful for the preparation of thermally stable high melting polyimides.Type: GrantFiled: September 4, 1990Date of Patent: June 2, 1992Assignee: Ethyl CorporationInventors: Allan A. Eisenbraun, Venkataraman Ramachandran
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Patent number: 5072046Abstract: This invention relates to a process for producing bis-[aminophenyl ketones] and the resulting compositions which are suitable for the preparation of engineering polymers, e.g., polyimides, polyurethanes and a host of other resinous materials. The bis-[aminophenyl ketones] are formed by reacting 2 moles of a nitrophenyl acid halide with an aromatic bridging composition having at least two hydrogen atoms of sufficient reactivity to undergo acylation reactions whereby nitrophenyl ketone groups are attached to the aromatic bridging group. The resulting bis-[nitrophenyl ketones] then are converted to the amine by hydrogenation or by double nucleophilic displacement with an aminophenol.The invention also relates to polyimides and polyamides prepared from such bis-[aminophenyl ketones].Type: GrantFiled: October 2, 1989Date of Patent: December 10, 1991Assignee: Air Products and Chemicals, Inc.Inventors: William F. Burogyne, Jr., Mark D. Conner, Michael E. Ford, Thomas A. Johnson
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Patent number: 5026872Abstract: Novel aromatic ether ketone diamine compounds and methods for their preparation are disclosed which comprise from about 3 to 8 aromatic rings interspersed with ether and ketone linkages. The novel ether ketone diamine compounds are useful as monomeric starting materials for the preparation of useful intermediates and useful thermoplastic and high temperature resistant polymers. In preferred embodiments, the novel ether ketone diamines are useful as curing agents for epoxy resin compositions and composite materials.Type: GrantFiled: February 1, 1984Date of Patent: June 25, 1991Assignee: American CyanamidInventor: Dalip K. Kohli