The Aryl Ring Or Ring System Is Bonded Directly To Another Ring Patents (Class 564/337)
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Publication number: 20150080438Abstract: The invention relates to selective oestrogen receptor modulators (SERMs) and to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.Type: ApplicationFiled: December 4, 2012Publication date: March 19, 2015Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Tim Wintermantel, Carsten Moeller, Ulrich Bothe, Reinhard Nubbemeyer, Ludwig Zorn, Antonius Ter Laak, Rolf Bohlmann, Lars Wortmann
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Publication number: 20150057240Abstract: Hsp90 C-terminal inhibitors and pharmaceutical compositions containing such compounds are provided. The compounds of the disclosure are useful for the treatment and/or prevention of neurodegenerative disorders such as diabetic peripheral neuropathy.Type: ApplicationFiled: February 8, 2013Publication date: February 26, 2015Inventors: Brian S. J. Blagg, Bhaskar Reddy Kusuma, Teather Sundstrom
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Publication number: 20150038705Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.Type: ApplicationFiled: October 6, 2014Publication date: February 5, 2015Inventors: DUSTIN WILLIAMS, RYAN LOOPER, SUJEEVINI JEYAPALINA, TRAVIS HAUSSENER, PAUL R. SEBAHAR, HARI KANNA REDDY
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Publication number: 20150031738Abstract: The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.Type: ApplicationFiled: December 10, 2012Publication date: January 29, 2015Applicant: University of MassachusettsInventors: Yan Li, Hitest Thaker, Gregory N. Tew, Dahui Liu, Wenxi Pan
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Publication number: 20140323763Abstract: The invention relates to the use of a substance of the general form (I) to produce an antibacterial and/or antifungal drug, wherein X is a methylene group or a carbonyl group; R1, R2, and R3 are each selected from the group comprising hydrogen, an alkyl group having a chain length of 1-4 carbon atoms, an alkoxy group having a chain length of 1-3 carbon atoms, and a halogen; R4 and R5 are each selected from the group comprising hydrogen and an alkyl group having a chain length of 1-4 carbon atoms; and n=3 to 6.Type: ApplicationFiled: December 21, 2011Publication date: October 30, 2014Applicant: CHRISTIAN-ALBRECHTS-UNIVERSITY OF KIELInventors: Franz Furkert, Bernd Clement, Britta Gerig, Dieter Heber
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Publication number: 20140308317Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.Type: ApplicationFiled: December 9, 2013Publication date: October 16, 2014Applicant: CELLCEUTIX CORPORATIONInventors: Xiaodong Fan, Yongjiang Xu, Dahui Liu, Michael J. Costanzo
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Patent number: 8853278Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.Type: GrantFiled: November 8, 2013Date of Patent: October 7, 2014Assignees: Curza Global, LLC, University of Utah Research FoundationInventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hari Kanna Reddy
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Publication number: 20140296559Abstract: This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The in vention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.Type: ApplicationFiled: August 16, 2012Publication date: October 2, 2014Applicants: DSM FINE CHEMICALS AUSTRIA NFG. GMBH & CO KG, DSM IP ASSETS B.V.Inventors: Petrus Johannes Hermsen, Peter Hans Ermann, Peter Hans Riebel, Michael Wolberg, Andreas Hendrikus Maria De Vries
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Patent number: 8846950Abstract: An embodiment of the invention is a novel Cr(V)OCO3? trianionic pincer ligand complex. Another embodiment of the invention is a catalytic method for oxidation of a substrate aerobically in the presence of a source of oxygen, where the novel Cr(V)OCO3? trianionic pincer ligand complex acts as the catalyst. The substrate can be a phosphine, amine, sulfide, alkene, alkane or a second metal complex. Another embodiment of the invention is directed to NCN pincer ligands that can form trianionic pincer ligand complexes.Type: GrantFiled: March 3, 2010Date of Patent: September 30, 2014Assignee: University of Florida Research Foundation, Inc.Inventors: Adam Steven Veige, Joseph Michael Falkowski, Matthew O'Reilly, Subramaniam Kuppuswamy, Kevin P. McGowan, Soumya Sarkar
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Publication number: 20140199547Abstract: The invention relates to a crosslinkable semiconductive polymer composition comprising (a) a polyolefin, carbon black and a compound (b), to a cable, preferably to a crosslinkable comprising the polymer composition, to a production thereof, and preferably to a crosslinked cable comprising the polymer composition of the invention.Type: ApplicationFiled: August 17, 2011Publication date: July 17, 2014Applicant: BOREALIS AGInventors: John Jamieson, Annika Smedberg, Christer Svanberg, Jenny-Ann Ostlund, Ola Fagrell, Perry Nylander, Takashi Uematsu, Thomas Hjertberg, Thomas Steffel
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Publication number: 20140135360Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: ApplicationFiled: November 8, 2013Publication date: May 15, 2014Applicant: Jacobus Pharmaceutical Company, IncInventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Patent number: 8716495Abstract: The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.Type: GrantFiled: December 21, 2011Date of Patent: May 6, 2014Assignee: Novartis AGInventors: David Hook, Thomas Ruch, Bernhard Riss, Bernhard Wietfeld, Gottfried Sedelmeier, Matthias Napp, Markus Bänziger, Steven Hawker, Lech Ciszewski, Liladhar M Waykole
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Patent number: 8669291Abstract: Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.Type: GrantFiled: June 2, 2008Date of Patent: March 11, 2014Assignee: Sunovion Pharmaceuticals Inc.Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Jianguo Ma, Seth Ribe, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, Rudy Schreiber, Kerry L. Spear
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Publication number: 20130252964Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.Type: ApplicationFiled: January 18, 2013Publication date: September 26, 2013Applicant: PolyMedix, Inc.Inventors: Richard W. Scott, Katie Freeman, Haizhong Tang, Gill Diamond
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Publication number: 20130252890Abstract: The invention relates to selective oestrogen receptor modulators (SERM) and methods of production thereof, use thereof for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases, in particular of bleeding disorders, osteoporosis, endometriosis, myomata, hormone-dependent tumours, for hormone replacement therapy and for contraception.Type: ApplicationFiled: June 21, 2011Publication date: September 26, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Tim Wintermantel, Carsten Möller, Ulrich Bothe, Reinhard Nubbemeyer, Ludwig Zorn, Dirk Kosemund, Antonius Ter Laak, Rolf Bohlmann, Lars Wortmann, Donald Bierer
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Patent number: 8415501Abstract: The present invention is directed to methods and compositions for making and using a new polymorph of cinacalcet hydrochloride.Type: GrantFiled: March 22, 2007Date of Patent: April 9, 2013Assignee: Amgen, Inc.Inventors: Belle B. Liu, Pengzu Zhou, Nina Cauchon
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Publication number: 20130047849Abstract: Porous bulk materials formed of shape-persistent, non-collapsible, three-dimensional molecular cage building blocks are presented that are useful for a variety of applications including gas separation/storage, sensing, and catalysis.Type: ApplicationFiled: March 18, 2011Publication date: February 28, 2013Inventors: Wei Zhang, Richard D. Noble, Yinghua Jin, Bret A. Voss
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Patent number: 8334308Abstract: The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.Type: GrantFiled: August 18, 2008Date of Patent: December 18, 2012Assignee: Merck Sharp & Dohme Corp.Inventors: Helene Juteau, Michel Gallant, Daniel Dube, Patrick Roy, Renee Aspiotis, Rejean Fortin, Patrick Lacombe, Daniel McKay, Tom Yao-Hsiang Wu
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Publication number: 20120232033Abstract: The invention relates to the use of compounds of formula I wherein the substituents are described in the description and claims for the treatment of psychoses, dysfunction in memory and learning, schizophrenia, dementia, attention deficit disorders or Alzheimer's disease. The invention also relates to some compounds of formula I and pharmaceutical compositions containing them.Type: ApplicationFiled: May 25, 2012Publication date: September 13, 2012Inventors: Sabine Kolczewski, Hans-Peter Marty, Robert Narquizian, Emmanuel Pinnard, Henri Stalder
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Patent number: 8183415Abstract: Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods.Type: GrantFiled: May 17, 2011Date of Patent: May 22, 2012Assignee: Amgen, Inc.Inventors: Oliver Thiel, Charles Bernard, Robert Larsen, Michael John Martinelli, Masooma Tamim Raza
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Patent number: 8148578Abstract: The present invention relates to pharmaceutical compositions containing Naratriptan, a compound selected from the group consisting of 2-HPOD, 2-HPHM, 4-PPED, 4-BPED and 2-PPED, and optionally, a pharmaceutically acceptable excipient.Type: GrantFiled: August 12, 2011Date of Patent: April 3, 2012Assignee: Emisphere Technologies Inc.Inventor: David Gschneidner
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Publication number: 20120010403Abstract: A production method of a compound containing a primary, secondary, or tertiary aminomethyl aromatic ring of the present invention includes: using a fluoroboron compound or a dimer thereof, or solvates thereof, which are represented by a formula (I): Ra(Rb)N—CH2—BF3M??(I) as an aminomethylating agent for an aromatic ring; and reacting the aminomethylating agent with an aromatic ring-containing compound, which can react with the aminomethylating agent, under the presence of a metal catalyst such as a palladium compound so as to perform the direct aminomethylation of the aromatic ring.Type: ApplicationFiled: September 21, 2011Publication date: January 12, 2012Inventor: Keigo TANAKA
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Publication number: 20110301244Abstract: The present invention relates to pharmaceutical compositions containing Naratriptan, a compound selected from the group consisting of 2-HPOD, 2-HPHM, 4-PPED, 4-BPED and 2-PPED, and optionally, a pharmaceutically acceptable excipient.Type: ApplicationFiled: August 12, 2011Publication date: December 8, 2011Applicant: Emisphere Technologies, Inc.Inventor: David GSCHNEIDNER
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Publication number: 20110263658Abstract: The present invention relates to biphenyl-based renin inhibitor compounds having amino-terminal groups, and their use in treating cardiovascular events and renal insufficiency.Type: ApplicationFiled: August 18, 2008Publication date: October 27, 2011Inventors: Helene Juteau, Michel Gallant, Daniel Dube, Patrick Roy, Renee Aspiotis, Rejean Fortin, Patrick Lacombe, Daniel McKay, Tom Yao-Hsiang Wu
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Patent number: 8044243Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is unsubstituted or substituted phenyl; or cycloalkyl; or a 5 or 6 membered heteroaromatic ring. Alternatively, the agent can be a pharmaceutically acceptable salt of the compound of Formula I.Type: GrantFiled: February 9, 2007Date of Patent: October 25, 2011Assignee: Wellstat Therapeutics CorporationInventors: Shalini Sharma, Reid W. von Borstel
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Publication number: 20110201690Abstract: The present application describes deuterium-enriched dapoxetine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: ApplicationFiled: August 18, 2010Publication date: August 18, 2011Applicant: PROTIA, LLCInventor: Anthony W. Czarnik
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Patent number: 7994365Abstract: Use of the substance characterized by general structural formula (I) for the preparation of an agent inhibiting the enzymatic activity of NO-synthase, R1, R2, R3, R4 and/or R5 being hydrogen, an alkyl group, an aryl group or a heterocyclic group and n equals 2 or 3.Type: GrantFiled: July 3, 2007Date of Patent: August 9, 2011Assignee: Christian-Albrechts-Universitaet Zu KielInventors: Bernd Clement, Dieter Heber, Ullvi Bluhm, Uwe Buss, Friederike Friedrich-Harder
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Publication number: 20110098425Abstract: This invention relates to Group 4 catalyst compounds containing di-anionic tridentate nitrogen/oxygen based ligands. The catalyst compounds are useful, with or without activators, to polymerize olefins, particularly a-olefins, or other unsaturated monomers. Systems and processes to oligomerize and/or polymerize one or more unsaturated monomers using the catalyst compound, as well as the oligomers and/or polymers produced therefrom are also provided.Type: ApplicationFiled: October 20, 2010Publication date: April 28, 2011Inventors: Garth R. Giesbrecht, Timothy M. Boller, Alexander Z. Voskoboynikov, Andrey F. Asachenko, Mikhail V. Nikulin, Alexey A. Tsarev
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Patent number: 7928257Abstract: This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (TON) and a high enantioselectivity. In the formula (I), Ar is represented by the following formula (VI) or (VII), wherein in the formula (VI), Xs are independently a halogen or a halogenated alkyl group and R1 and R2s are independently hydrogen or an alkyl group or a trialkylsilyl group having a carbon number of 1-4, and in the formula (VII), R3 is a bulky group.Type: GrantFiled: January 5, 2010Date of Patent: April 19, 2011Assignee: Japan Science and Technology AgencyInventors: Tsutomu Katsuki, Kazufumi Omura, Tatsuya Uchida, Ryo Irie
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Publication number: 20110037063Abstract: The present invention relates to a compound of the formula (1) and (2) The invention further relates to a process to produce the compound. The invention additionally relates and an electronic device containing the compound of the formula (1) or (2). The electronic device can be an organic electroluminescence devices, particularly a blue emitting device, in which compounds are used as host materials or dopants in the emitting layer and/or as hole transport materials and/or as electron transport materials.Type: ApplicationFiled: March 17, 2009Publication date: February 17, 2011Applicant: Merck Patent GmbHInventors: Arne Buesing, Holger Heil, Philipp Stoessel
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Patent number: 7834062Abstract: The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making the compounds. This and other aspects of the invention are realized upon review of the entire specification.Type: GrantFiled: August 13, 2009Date of Patent: November 16, 2010Assignee: Merck Sharp & Dohme Corp.Inventors: Conrad P. Dorn, Mary Ann Powles, Thomas F. Walsh, Matthew J. Wyvratt
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Publication number: 20100273745Abstract: Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors of the enzyme lysine-specific demethylase-1.Type: ApplicationFiled: April 20, 2010Publication date: October 28, 2010Applicants: THE JOHNS HOPKINS UNIVERSITY, WAYNE STATE UNIVERSITYInventors: Patrick M. Woster, Tracey Boncher, Robert Casero
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Publication number: 20100249400Abstract: Disclosed is a compound represented by the formula (I) below as a dihydronaphthalene compound having a chemical structure which is excellent in production efficiency when compared with lasofoxifene and nafoxidine. This compound is useful as a proteasome inhibitor and/or an antitumor agent.Type: ApplicationFiled: September 11, 2008Publication date: September 30, 2010Applicant: Tokyo University of Science Educational Foundation Administrative OrganizationInventor: Isamu Shiina
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Publication number: 20100234641Abstract: Use of the substance characterized by general structural formula (I) for the preparation of an agent inhibiting the enzymatic activity of NO-synthase, R1, R2, R3, R4 and/or R5 being hydrogen, an alkyl group, an aryl group or a heterocyclic group and n equals 2 or 3.Type: ApplicationFiled: July 3, 2007Publication date: September 16, 2010Applicant: CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIELInventors: Bernd Clement, Dieter Heber, Ullvi Bluhm, Uwe Buss, Friederike Friedrich-Harder
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Publication number: 20100173811Abstract: Para-alkylated substituted diphenylamines are made by catalytically alkylating diphenylamine with a branched-chain alkene, such as propene, oligomer mixture in which the oligomer present in the greatest percentage has 15-24 carbon atoms. The alkylated diphenylamines are useful crankcase lubricant additives such as for reducing piston deposits and engine sludge.Type: ApplicationFiled: June 6, 2008Publication date: July 8, 2010Inventors: Stephen Arrowsmith, Christopher J. Booth, Aubrey L. Burrows, Paul Wilson, Neal J. Milne, Lin Wangkan, Jacob Emert, Laurent Chambard
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Publication number: 20100152252Abstract: The present invention relates to heterocyclyl-substituted-ethylamino-phenyl compounds of general formula (I), wherein K-L-M-N, Z and R1, R2, R3, R4 are as described in the claims methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.Type: ApplicationFiled: December 21, 2007Publication date: June 17, 2010Applicant: LABORATORIOS DEL DR. ESTEVE,S.A.Inventors: Mónica Garcia-López, Antonio Torrens-Jover, Luz Romero-Alonso, Helmut H. Buschmann
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Patent number: 7737295Abstract: Compounds of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula 1, A1 and A2 are each an aromatic ring, a 5-6-membered heterocyclic ring, an aromatic ring fused to a heterocyclic ring, a phenyl ring fused to a heterocyclic ring, or a cycloalkyl ring.Type: GrantFiled: April 8, 2005Date of Patent: June 15, 2010Assignee: Merck Sharp & Dohme Corp.Inventors: Amjad Ali, Joann Bohn, Qiaolin Deng, Zhijian Lu, Peter J. Sinclair, Gayle E. Taylor, Christopher F. Thompson, Nazia Quraishi
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Publication number: 20100113815Abstract: This invention provides a method for producing an optically active aziridine compound or amine compound, which uses as a catalyst a Ru(salen)(CO) complex represented by the following formula (I) or its enantiomer having a high stability, in a high turnover number (TON) and a high enantioselectivity. In the formula (I), Ar is represented by the following formula (VI) or (VII), wherein in the formula (VI), Xs are independently a halogen or a halogenated alkyl group and R1 and R2s are independently hydrogen or an alkyl group or a trialkylsilyl group having a carbon number of 1-4, and in the formula (VII), R3 is a bulky group.Type: ApplicationFiled: January 5, 2010Publication date: May 6, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Tsutomu Katsuki, Kazufumi Omura, Tatsuya Uchida, Ryo Irie
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Publication number: 20090275780Abstract: The invention relates to a process for tightly controlling the particle size of cinacalcet hydrochloride, i.e. a process for preparing large or small crystals of cinacalcet hydrochloride, which yields cinacalcet hydrochloride in a narrow, reproducible and consistent distribution of particles, which hence does not require to reprocess, rework or destroy material of undesired size, which is efficient and cost-effective, and which is suitable for industrial implementation.Type: ApplicationFiled: May 4, 2009Publication date: November 5, 2009Applicant: MEDICHEM, S.A.Inventor: Bernardino MANGION
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Publication number: 20090253936Abstract: A process for producing (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or mixtures thereof.Type: ApplicationFiled: February 27, 2009Publication date: October 8, 2009Applicant: Gruenenthal GmbHInventors: Helmut Heinrich BUSCHMANN, Wolfgang Hell, Joerg Holenz, Oswald Zimmer, Irene Vaulont, Dieter Haag, Emad El Sayed, Robert Hett, Alfed Olbrich, Lars Pumpenmeier
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Patent number: 7592487Abstract: The invention relates to the compounds of formula: (I) which are as defined in the specification. Their use as chiral ligands in catalytic aryl transfer reactions to aromatic aldehydes is also described.Type: GrantFiled: March 10, 2005Date of Patent: September 22, 2009Assignee: The Hong Kong Polytechnic UniversityInventors: Albert Sun-Chi Chan, Jianxin Ji
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Patent number: 7589127Abstract: The present invention relates to Mannich base antimalarial aminoalkylphenol compounds and their use against protozoa of the genus Plasmodium, particularly emerging strains of drug-resistant Plasmodia. This invention further relates to compositions containing such compounds and a process for making the compounds. This and other aspects of the invention are realized upon review of the entire specification.Type: GrantFiled: June 20, 2003Date of Patent: September 15, 2009Assignee: Merck & Co., Inc.Inventors: Conrad P. Dorn, Mary Ann Powles, Thomas F. Walsh, Matthew J. Wyvratt
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Patent number: 7563930Abstract: Provided are crystalline forms of Cinacalet HCl and processes for their preparation.Type: GrantFiled: November 22, 2006Date of Patent: July 21, 2009Assignee: Teva Pharmaceutical Industries LtdInventors: Shlomit Wizel, Revital Lifshitz-Liron, Sharon Avhar-Maydan
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Publication number: 20090076163Abstract: The present application describes deuterium-enriched dapoxetine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: ApplicationFiled: August 22, 2008Publication date: March 19, 2009Applicant: PROTIA, LLCInventor: Anthony W. Czarnik
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Publication number: 20090015144Abstract: A fluoranthene compound with a specified asymmetric structure; an organic EL device which is composed of one or more organic compound layers including at least one emitting layer sandwiched between a pair of electrodes, wherein at least one of the organic compound layers contains at least one kind of the fluoranthene compound; and a solution containing a material for the organic EL which is composed of the fluoranthene compound as the material for the organic EL and a solvent. An organic electroluminescence (EL) device having a superior luminance of light emission, an enhanced efficiency of light emission, and a prolonged lifetime and a compound realizing the device are provided.Type: ApplicationFiled: October 31, 2007Publication date: January 15, 2009Applicant: Idemitsu Kosan Co., Ltd.Inventors: Yoriyuki Takashima, Masakazu Funahashi, Kiyoshi Ikeda, Tetsuya Inoue, Chishio Hosokawa, Yumiko Mizuki
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Publication number: 20090005456Abstract: Phenyl-substituted cyclohexylamine derivatives and method for their synthesis and characterization are disclosed. Use of these compounds to treat/prevent neurological disorders as well as methods for their synthesis are set forth herein. Exemplary compounds of the invention inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations incorporating compounds of the invention are also provided.Type: ApplicationFiled: June 2, 2008Publication date: January 1, 2009Applicant: SEPRACOR INC.Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Jianguo Ma, Seth Ribe, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, Rudy Schreiber, Kerry L. Spear
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Patent number: 7468459Abstract: The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of a prochiral beta amino acrylic acid derivative substrate in the presence of a transition metal precursor complexed with a chiral ferrocenyl diphosphine ligand.Type: GrantFiled: March 15, 2004Date of Patent: December 23, 2008Assignee: Merck & Co., Inc.Inventors: Yi Xiao, Joseph D. Armstrong, III, Shane W. Krska, Eugenia Njolito, Nelo R. Rivera, Yongkui Sun, Thorsten Rosner
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Patent number: 7449603Abstract: Provided is a process for preparing Cinacalcet, (R)-?-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine and intermediates thereof.Type: GrantFiled: April 27, 2007Date of Patent: November 11, 2008Assignee: Teva Pharmaceutical Industries Ltd.Inventor: Revital Lifshitz-Liron
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Patent number: 7446227Abstract: A process for preparation of protriptyline hydrochloride from 5-dihydrobenzocycloheptatriene of formula (1) by coupling with chloropropyl alcohol in the presence of excess n-butyl Lithium in tetrahydrofuran under inert atmosphere, followed by preparation of mesylate derivative of formula (3) and finally the nucleophilic displacement of the mesylate group by reacting methylamine solution in methanol to give protriptyline free base of the formula (4). Also the present process reveals the hydrochloride salt formation and purification of the same to give pure pharmaceutical grade protriptyline hydrochloride with impurities less than 0.1% w/w.Type: GrantFiled: December 11, 2006Date of Patent: November 4, 2008Assignee: Apicore, LLCInventors: Satyam Nampalli, Brijesh Patel, Peter Xavier Tharial, Ravishanker Kovi
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Publication number: 20080262267Abstract: The present invention relates to processes for the preparation of 4-hydroxy-??-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-hydroxy-2-naphthoate (salmeterol xinafoate) (12a), the preparation of 4-hydroxy-??-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol (salmeterol) (11), the preparation of protected N-[6-(4-phenylbutoxy)hexyl]amine intermediates (7), and the preparation of 6-substituted (4-phenylbutoxy)hexane intermediates (5), shown below, wherein X is a leaving group and Pg is a protecting group.Type: ApplicationFiled: April 16, 2008Publication date: October 23, 2008Applicant: Generics [UK] LimitedInventors: Vinayak G. Gore, Avinash C. Gaikwad, M. Gadkar, V.K. Shukla