The Chain Contains Nitrogen Between The Aryl Ring Or Ring System And Amino Nitrogen Patents (Class 564/367)
  • Patent number: 9314509
    Abstract: The present invention relates to improvements in compositions containing peptides that are ligands of one or more of the melanocortin receptors (MC-R), or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and method of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of Ac-Arg-cyclo(Cys-D-Ala-His-D-Phe-Arg-Trp-Cys)-NH2 which is a ligand of the melanocortin receptor subtype 4 (MC4-R), and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms a depot at physiological pH that is slowly dissolved and released into the body fluid and bloodstream. The present invention may further comprise an organic component such as dimethylacetamide (DMA) or polyethylene glycol (PEG) with an average molecular weight of lower than 1000.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: April 19, 2016
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Zheng Xin Dong, Jundong Zhang
  • Patent number: 9034085
    Abstract: A composition of matter, and method to make same, for a nano-based material including a nanocarbon support to which is attached an aliphatic amine. In particular, the composition of matter is an aliphatic amine-nanocarbon material that includes a nanocarbon (NC) support, such as C60, nano-graphite, graphene, nanocarbon ribbons, graphite intercalation compounds, graphite oxide, nano-coal, nanohorns, and combinations thereof, and further includes an aliphatic amine, such as polyethyleneimine (PEI).
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: May 19, 2015
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Andrew R. Barron, Eoghan Dillon
  • Publication number: 20150045444
    Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.
    Type: Application
    Filed: October 24, 2014
    Publication date: February 12, 2015
    Inventors: Ian Leslie Scott, Vladimir Aleksandrovich Kuksa, Mark W. Orme, Thomas Little, Anna Gall, Jennifer Gage, Feng Hong
  • Publication number: 20150038512
    Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
    Type: Application
    Filed: October 6, 2014
    Publication date: February 5, 2015
    Inventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hariprasada R. Kanna Reddy
  • Publication number: 20150038705
    Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
    Type: Application
    Filed: October 6, 2014
    Publication date: February 5, 2015
    Inventors: DUSTIN WILLIAMS, RYAN LOOPER, SUJEEVINI JEYAPALINA, TRAVIS HAUSSENER, PAUL R. SEBAHAR, HARI KANNA REDDY
  • Publication number: 20150017231
    Abstract: Disclosed herein are di-substituted aryl polyamine compounds and methods of making and using the same. The di-substituted polyamine compounds act as PTS targeting agents, which selectively target the polyamine transport system (PTS) with high efficacy and have improved stability in the presence of amine oxidases.
    Type: Application
    Filed: March 14, 2013
    Publication date: January 15, 2015
    Applicant: University of Central Florida Research Foundation, Inc.
    Inventors: Otto Phanstiel, IV, Aaron Muth
  • Publication number: 20140303333
    Abstract: The present application, relates to iron bisphenolate complexes and methods of use and synthesis thereof. The iron complexes are prepared from tridentate or tetradentate ligands of Formula I: wherein R1 and R2 are as defined herein. Also provided are methods and processes of using the iron bisphenolate complexes as catalysts in cross-coupling reactions and in controlled radical polymerizations.
    Type: Application
    Filed: October 15, 2012
    Publication date: October 9, 2014
    Inventors: Michael P. Shaver, Christopher M. Kozak
  • Patent number: 8853278
    Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: October 7, 2014
    Assignees: Curza Global, LLC, University of Utah Research Foundation
    Inventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hari Kanna Reddy
  • Publication number: 20140296575
    Abstract: The present invention relates to a multi-branched Mannich base corrosion inhibitor and the method for preparing thereof. The method comprises (1) adding 3˜7 moles ketone and 3˜7 moles aldehyde to reaction kettle, adjusting pH to 2˜6 with acid, controlling temperature to 20˜50° C. and stirring for 20˜30 mins; (2) adding 1 mole organic polyamine to the reaction kettle under stirring, or adding the pH-adjusted ketone, aldehyde and organic solvent to organic polyamine, controlling temperature to 60˜90° C. and reacting for 1˜3 hrs, and after completion of the reaction, heating the system to 110° C. under nitrogen to remove water; the organic polyamine is organic compound comprising three or more primary amine groups and/or secondary amine groups.
    Type: Application
    Filed: April 27, 2012
    Publication date: October 2, 2014
    Applicant: PetroChina Company Limited
    Inventors: Ling Ma, Lei Li, Xiangjun Kong, Malike Dilibai, Xinping Zhen, Chunge Niu, Shengjun Bai
  • Publication number: 20140295088
    Abstract: Disclosed are flexible polyamines, flexible amine-terminated polyformal adducts, flexible-amine-terminated polythioether adducts, compositions comprising flexible polyamines and isocyanate-terminated prepolymers, and compositions comprising flexible amine-terminated adducts and isocyanate-terminated prepolymers. Uses of the compositions as sealants, and particularly as aerospace sealants, are also disclosed.
    Type: Application
    Filed: June 18, 2014
    Publication date: October 2, 2014
    Inventors: Stephen J. Hobbs, Marfi Ito, Juexiao Cai, Chandra Rao, Renhe Lin
  • Publication number: 20140245541
    Abstract: An agent for the oxidative dyeing of keratinous fibres is provided. The agent contains, as a developer-type oxidation dye precursor, a compound of Formula (I) that carries at least one cationic charge in Y.
    Type: Application
    Filed: May 29, 2012
    Publication date: September 4, 2014
    Applicant: Henkel AG & Co. KGaA
    Inventors: Wibke Gross, Ralph Nemitz, Astrid Kroos
  • Patent number: 8636830
    Abstract: A composition of matter, and method to make same, for a nano-based material including a nanocarbon support to which is attached an aliphatic amine. In particular, the composition of matter is an aliphatic amine-nanocarbon material that includes a nanocarbon (NC) support, such as C60, nano-graphite, graphene, nanocarbon ribbons, graphite intercalation compounds, graphite oxide, nano-coal, nanohorns, and combinations thereof, and further includes an aliphatic amine, such as polyethyleneimine (PEI).
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: January 28, 2014
    Assignee: William Marsh Rice University
    Inventors: Andrew R. Barron, Eoghan Dillon
  • Publication number: 20140011857
    Abstract: The invention provides for novel compounds which are inhibitors of lysine-specific demethylase 1 (LSD1). Such compounds may be used to treat disorders, including cancer.
    Type: Application
    Filed: September 12, 2011
    Publication date: January 9, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Robert A. Casero, Ian Bytheway, Patrick M. Woster
  • Patent number: 8624064
    Abstract: The present invention relates to a compound represented by the following general formula (I): wherein R1 and R2 independently represent a monovalent hydrocarbon group; R3 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X represents a divalent hydrocarbon group; and R4, R5 and R6 independently represent a monovalent organic group or a group represented by the following general formula (II): in which R7 and R8 independently represent a monovalent hydrocarbon group; and R9 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, with the proviso that R5 and R6 may combine together to form a divalent hydrocarbon group. The aforementioned compounds are useful as a polymerization inhibitor and the like.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: January 7, 2014
    Assignee: Dow Corning Toray Company, Ltd.
    Inventors: Takeaki Saiki, Keiji Wakita, Yasushi Sugiura, Yoshinori Taniguchi
  • Publication number: 20130237681
    Abstract: The present invention relates to novel amides having secondary amino groups, a process for preparing them, adducts of these amines and their uses. The amides can be prepared in a simple way from readily available starting materials. They and their adducts have, in particular, a low viscosity and are suitable as constituent of polyurethane and polyurea compositions having excellent processability and high flexibility, and also as constituent of epoxy resin compositions, in particular coatings.
    Type: Application
    Filed: December 13, 2011
    Publication date: September 12, 2013
    Applicant: SIKA TECHNOLOGY AG
    Inventor: Urs Burckhardt
  • Publication number: 20130237466
    Abstract: The present invention relates to the use of amines and/or Mannich adducts as detergents and/or dispersants in fuel and lubricant compositions for direct-injection gasoline engines. The invention further relates to fuel and lubricant compositions which comprise at least one such Mannich adduct, and also a bisaminoalkylated Mannich adduct.
    Type: Application
    Filed: April 25, 2013
    Publication date: September 12, 2013
    Applicant: BASF SE
    Inventors: Arno LANGE, Hans Peter RATH, Marc WALTER, Marco BERGEMANN, Helmut SCHMIDT
  • Patent number: 8501659
    Abstract: A process for the preparation of N-arylamine compounds, the process including: reacting a compound having an amino group with an acylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an N-arylamine compound; wherein the transition metal catalyst comprises a complex of a Group 8-10 metal and at least one chelating ligand comprising (R)-(?)-1-[(S)-2-dicyclohexylphosphino]-ferrocenyl]ethyldi-t-butylphosphine.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: August 6, 2013
    Assignee: Univation Technologies, LLC
    Inventor: Adam M. Johns
  • Patent number: 8496716
    Abstract: Polyisobutenylphenol-containing Mannich adducts are prepared by a) alkylation of a phenol with highly reactive polyisobutene at below about 50° C. in the presence of an alkylation catalyst; b) reaction of the reaction product from a) with formaldehyde, an oligomer or a polymer of formaldehyde and at least one amine which has at least one secondary amino function and no primary amino function, or c) reaction of the reaction product from a) with at least one adduct of at least one amine which has at least one secondary or primary amino function and formaldehyde, an oligomer of formaldehyde, a polymer of formaldehyde or a formaldehyde equivalent, and are used as detergent additives in fuel and lubricant compositions, and additive concentrates, fuel compositions and lubricant compositions contain these Mannich adducts.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: July 30, 2013
    Assignee: BASF SE
    Inventors: Arno Lange, Hans Peter Rath, Dietmar Posselt, Irene Troetsch-Schaller, Marc Walter
  • Patent number: 8409474
    Abstract: The use of polycyclic phenolic compounds which have up to 20 benzene rings per molecule and are obtainable by reacting a tetrahydrobenzoxazine I where R1 is a hydrocarbyl radical and R2, R3, R4 and R5 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals with one or more of the same or different phenols II where R7, R8, R9 and R10 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals, and/or with one or more of the same or different tetrahydrobenzoxazines I, with the proviso that at least one of the substituents has from 13 to 3000 carbon atoms and the remaining substituents, when they are hydrocarbyl radicals, have in each case from 1 to 20 carbon atoms as stabilizers for stabilizing inanimate organic material against the action of light, oxygen and heat.
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: April 2, 2013
    Assignee: BASF SE
    Inventors: Arno Lange, Helmut Mach, Hans Peter Rath, Dietmar Posselt
  • Publication number: 20130071571
    Abstract: Disclosed are flexible polyamines, flexible amine-terminated polyformal adducts, flexible-amine-terminated polythioether adducts, compositions comprising flexible polyamines and isocyanate-terminated prepolymers, and compositions comprising flexible amine-terminated adducts and isocyanate-terminated prepolymers. Uses of the compositions as sealants, and particularly as aerospace sealants, are also disclosed.
    Type: Application
    Filed: September 21, 2011
    Publication date: March 21, 2013
    Applicant: PRC DeSoto International, Inc.
    Inventors: Stephen J. Hobbs, Marfi Ito, Juexiao Cai, Chandra Rao, Renhe Lin
  • Patent number: 8377336
    Abstract: The use of polycyclic phenolic compounds which have up to 20 benzene rings per molecule and are obtainable by reacting a tetrahydrobenzoxazine I where R1 is a hydrocarbyl radical and R2, R3, R4 and R5 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals with one or more of the same or different phenols II where R7, R8, R9 and R10 are each independently hydrogen atoms, hydroxyl groups or hydrocarbyl radicals, and/or with one or more of the same or different tetrahydrobenzoxazines I, with the proviso that at least one of the substituents has from 13 to 3000 carbon atoms and the remaining substituents, when they are hydrocarbyl radicals, have in each case from 1 to 20 carbon atoms as stabilizers for stabilizing inanimate organic material against the action of light, oxygen and heat.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: February 19, 2013
    Assignee: BASF SE
    Inventors: Arno Lange, Helmut Mach, Hans Peter Rath, Dietmar Posselt
  • Patent number: 8227643
    Abstract: This invention relates to bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable salts and their use in the modulation of Sirtuin 1 (Sirt1) and there use in neuroprotection for subject suffering from neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, including Parkinson's plus diseases such as multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration and dementia with Lewy bodies, and in the manufacture of medicaments for such Sirt1 modulation and neuroprotection.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: July 24, 2012
    Assignee: ProteoTech, Inc.
    Inventors: Alan D. Snow, Qubai Hu, Judy A. Cam
  • Publication number: 20120183984
    Abstract: The invention provides compounds of formula I F-L-Q (I) where F comprises a fluorophore capable of absorbing energy at an excitation wavelength and, in the absence of a quencher, emitting energy at an emission wavelength, which is different than the excitation wavelength; Q comprises a quencher; L comprises a linker moiety having two ends, one end being covalently bound to F and the other end being covalently bound to Q. The compounds are capable of undergoing a reversible reaction (1), provided below: (1) where Q+ is an oxidized form of Q representing the absence of a quencher, Ox comprises an oxidizing agent, which is capable of oxidizing Q to its oxidized form Q, and Red comprises a reducing agent, which is capable of converting Q back to its reduced form Q. The compounds can undergo photo-induced electron transfer when irradiated with energy and when Q exists in its oxidized form, Q+.
    Type: Application
    Filed: July 22, 2010
    Publication date: July 19, 2012
    Applicant: OPTI MEDICAL SYSTEMS
    Inventors: Huarui He, Chao Lin
  • Publication number: 20120172449
    Abstract: Novel polyamine transport inhibitors have been synthesized and demonstrated to block the uptake of native polyamines into human cancer cells. A combination therapy of the transport inhibitor and DFMO (a drug which blocks polyamine biosynthesis) provided synergistic activity against a metastatic human colon cancer cell line. The strategy uses polyamine depletion and polyamine metabolism to generate reactive oxygen species within cells as a novel way to treat cancers. This approach may be implemented for widespread use in the treatment of diseases which rely upon polyamine transport activity for proliferation.
    Type: Application
    Filed: June 21, 2010
    Publication date: July 5, 2012
    Inventors: Otto Phanstiel, Jennifer J. Archer
  • Publication number: 20120101271
    Abstract: Selective intramolecular C—H amination via metalloradical activation of azides: synthesis of 1,3-diamines under neutral and nonoxidative conditions. One aspect of the present invention is the synthesis of 1,3-diamines by intramolecular C—H amination of sulfamoyl azides. More specifically, sulfamoyl azides may be selectively aminated via metalloradical activation of azides, preferably with Co(II) porphyrins. In a particularly preferred embodiment, the Co(II) porphyrin is a D2h-symmetric porphyrin.
    Type: Application
    Filed: October 21, 2011
    Publication date: April 26, 2012
    Inventors: X. Peter Zhang, Hongjian Lu
  • Patent number: 8118968
    Abstract: A bonding agent system is provided that contains at least components (A) and (B), where (A) is at least one compound with at least two cyclic carbonate groups and (B) is at least one compound with at least two primary and/or secondary amine groups. The bonding agent system is particularly suitable for use as a two-component adhesive or sealant and has very good adhesion to various substrates.
    Type: Grant
    Filed: January 8, 2007
    Date of Patent: February 21, 2012
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Moeller, Hans-Georg Kinzelmann
  • Publication number: 20120024153
    Abstract: A composition of matter, and method to make same, for a nano-based material including a nanocarbon support to which is attached an aliphatic amine. In particular, the composition of matter is an aliphatic amine-nanocarbon material that includes a nanocarbon (NC) support, such as C60, nano-graphite, graphene, nanocarbon ribbons, graphite intercalation compounds, graphite oxide, nano-coal, nanohorns, and combinations thereof, and further includes an aliphatic amine, such as polyethyleneimine (PEI).
    Type: Application
    Filed: June 13, 2011
    Publication date: February 2, 2012
    Applicant: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Andrew R. Barron, Eoghan Dillon
  • Patent number: 8016898
    Abstract: Polyisobutenylphenol-containing Mannich adducts are prepared by a) alkylation of a phenol with highly reactive polyisobutene having a number average molecular weight of less than 1000 and a polydispersity of less than 3.0, at below about 50° C. in the presence of an alkylation catalyst; b) reaction of the reaction product from a) with b1) an aldehyde chosen from formaldehyde, an oligomer and a polymer of formaldehyde and b2) at least one amine which has at least one primary or one secondary amino function and are used as detergent additives in fuel and lubricant compositions, and additive concentrates, fuel compositions and lubricant compositions contain these Mannich adducts.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: September 13, 2011
    Assignee: BASF Aktiengesellschaft
    Inventors: Arno Lange, Hans Peter Rath, Dietmar Posselt, Irene Trötsch-Schaller, Marc Walter
  • Publication number: 20110207599
    Abstract: A process for the preparation of N-arylamine compounds, the process including: reacting a compound having an amino group with an acylating compound in the presence of a base and a transition metal catalyst under reaction conditions effective to form an N-arylamine compound; wherein the transition metal catalyst comprises a complex of a Group 8-10 metal and at least one chelating ligand comprising (R)-(?)-1-[(S)-2-dicyclohexylphosphino]-ferrocenyl]ethyldi-t-butylphosphine.
    Type: Application
    Filed: October 21, 2009
    Publication date: August 25, 2011
    Applicant: UNIVATION TECHNOLOGIES, LLC
    Inventor: Adam M. Johns
  • Patent number: 7988749
    Abstract: Polyisobutenylphenol-containing Mannich adducts are prepared by a) alkylation of a phenol with highly reactive polyisobutene at below about 50° C. in the presence of an alkylation catalyst; b) reaction of the reaction product from a) with formaldehyde, an oligomer or a polymer of formaldehyde and at least one amine which has at least one secondary amino function and no primary amino function, or c) reaction of the reaction product from a) with at least one adduct of at least one amine which has at least one secondary or primary amino function and formaldehyde, an oligomer of formaldehyde, a polymer of formaldehyde or a formaldehyde equivalent, and are used as detergent additives in fuel and lubricant compositions, and additive concentrates, fuel compositions and lubricant compositions contain these Mannich adducts.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: August 2, 2011
    Assignee: BASF SE
    Inventors: Arno Lange, Hans Peter Rath, Dietmar Posselt, Irene Troetsch-Schaller, Marc Walter
  • Patent number: 7977512
    Abstract: Disclosed is a benzonitrile derivative which is useful as a production intermediate for benzylamine derivative represented by the general formula (5) below and s secondary amine derivative represented by the general formula (9) below. Also disclosed are a method for producing such a benzonitrile derivative and a use thereof as a bactericide. Specifically disclosed are a novel benzonitrile derivative represented by the general formula (1) below, a salt thereof, a production method thereof, and a use thereof as a pharmaceutical intermediate or a bactericide. [Chemical formula 1] (5) (In the formula, n represents an integer of 0-3, and R1 represents a hydrogen, a linear or branched alkyl group having 1-6 carbon atoms or the like.) [Chemical formula 2] (9) (In the formula, n and R1 are a defined above, and R4 represents a hydrogen, a linear or branched alkl group having 1-6 carbon atoms or the like.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: July 12, 2011
    Assignee: Kureha Corporation
    Inventors: Hideki Iwama, Junko Sudo, Susumu Shimizu, Masataka Katohno, Masashi Yamamoto, Shigeru Suzuki, Hiroshi Hoshino, Nanako Kuruhara
  • Publication number: 20110154583
    Abstract: Dyes, compositions comprising dyes and methods for using the same are provided.
    Type: Application
    Filed: December 21, 2010
    Publication date: June 30, 2011
    Applicant: Living Proof, Inc.
    Inventors: Jana Lewis, Lorna Nagamoottoo-Casse, David Puerta
  • Publication number: 20110108826
    Abstract: The present invention relates to a novel anthracene derivative and an organic electronic device using the same. The anthracene derivative can act as a hole injecting, hole transporting, electron injecting and transporting, or light emitting material in an organic light emitting device and an organic electronic device. In particular, the anthracene derivative can act as a light emitting host. The organic electronic device according to the present invention has excellent characteristics in views of efficiency, the driving voltage, and the stability.
    Type: Application
    Filed: July 10, 2009
    Publication date: May 12, 2011
    Inventors: Hye-Young Jang, Se-Hwan Son, Jae-Soon Bae, Jun-Gi Jang, Tae-Yoon Park
  • Publication number: 20110112073
    Abstract: The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixtures thereof), and pharmaceutical Formulations thereof. In particular, the present invention provides compounds capable of facilitating HSF1 homotrimerization, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with irregular HSF1 activity.
    Type: Application
    Filed: November 12, 2010
    Publication date: May 12, 2011
    Applicant: DUKE UNIVERSITY
    Inventors: Dennis J. Thiele, Daniel W. Neef, Jose S. Mendoza
  • Patent number: 7812184
    Abstract: [Problem] To provide a production method of optically active epoxy compound, and a complex used for the production method and a production method of the complex. [Means for solving the problem] The skeleton that is necessary for expressing a high catalyst activity of optically active titanium salan complex of formulae (1) and (1?) and the substituent that is useful therefor and the position of the substituent are identified, and it is found that optically active epoxy compounds can be produced with a high enantioselectivity and a high chemical yield compared with a case where the prior optically active titanium salan complex is used. The production method comprises subjecting a prochiral compound (formula (4), (5) or (6)) having carbon-carbon double bond in the molecule to asymmetric epoxidation to produce an optically active epoxy compound (formula (7), (8) or (9)). The present invention relates also to a complex used for the production method and a production method of the complex.
    Type: Grant
    Filed: November 8, 2007
    Date of Patent: October 12, 2010
    Assignee: Nissan Chemical Industries, Ltd.
    Inventors: Shoichi Kondo, Kazuhiro Matsumoto, Yuji Sawada, Tsutomu Katsuki
  • Publication number: 20100247439
    Abstract: Provided are dendritic nano-antioxidant compounds according to Formula I, which may further comprise active agents covalently or non-covalently attached. Further provided are compositions comprising the disclosed compounds. Also disclosed are cosmetic compositions and dietary supplements comprising the compounds according to Formula I. The invention additionally provides methods of reducing free radicals or oxidative stress in a cell, a method of treating a subject, and a method of treating a condition comprising administering the compounds according to Formula I.
    Type: Application
    Filed: March 29, 2010
    Publication date: September 30, 2010
    Inventor: Choon Young Lee
  • Publication number: 20100187520
    Abstract: Disclosed is a light emitting device material characterized by containing a specific fluorine compound. This light emitting device material enables to obtain a light emitting device having high luminous efficiency, excellent color purity and excellent durability. Also disclosed is a light emitting device using such a light emitting device material.
    Type: Application
    Filed: July 16, 2008
    Publication date: July 29, 2010
    Applicant: Toray Industries, Inc.
    Inventors: Kazunori Sugimoto, Tsuyoshi Tominaga
  • Patent number: 7728040
    Abstract: Polyamine compounds, method of synthesis and method of use for anti-cancer purposes, for enhancing the activity of existing anti-cancer drugs, as well as, for inhibiting N-Methyl-D-Aspartate (NMDA) receptors found in neurotransmission systems are provided. Certain polyamine motifs have been identified that can be attached to toxic agents to facilitate their access to cancer cells as well as polyamine compounds of surprising cytotoxicity with selectivity in killing cancer cells, and surprising utility in the treatment of Alzheimer's disease and brain stroke. It includes an illustrative conjugate system with examples of a triamine or a tetraamine appended to a cytotoxic agent. Included is a general strategy to enhance cell uptake by attaching a polyamine vectoring system with an example of a triamine vector attached to an existing anti-cancer drug to improve its chemotherapeutic potency.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: June 1, 2010
    Assignee: University of Central Florids Research Foundation, Inc.
    Inventor: Otto Phanstiel
  • Publication number: 20100125144
    Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with tetradentate ligands having at least one amino or imino coordinating group and at least one phosphino coordinating group in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 20, 2010
    Inventors: LIONEL SAUDAN, PHILIPPE DUPAU, JEAN-JACQUES RIEDHAUSER, PATRICK WYSS
  • Patent number: 7714170
    Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, use in the reduction of A? peptide in vivo, use in modulating APP processing, and use in modulating the activity of APP secretase.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: May 11, 2010
    Assignee: Proteotech, Inc.
    Inventors: Alan D. Snow, Qubai Hu, Judy A. Cam
  • Publication number: 20100062460
    Abstract: Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest.
    Type: Application
    Filed: October 13, 2008
    Publication date: March 11, 2010
    Inventors: Praveen Pande, Yuejun Xiang, Wayne Forrest Patton
  • Publication number: 20100009970
    Abstract: The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease.
    Type: Application
    Filed: March 18, 2009
    Publication date: January 14, 2010
    Applicant: Combinatorx (Singapore) Pte. Ltd.
    Inventors: Lisa M. Johansen, Christopher M. Owens, Christina Mawhinney, Todd W. Chappell, Alexander T. Brown, Michael G. Frank, Michael A. Foley, Ralf Altmeyer, Yu Chen
  • Publication number: 20090275664
    Abstract: Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.
    Type: Application
    Filed: July 15, 2009
    Publication date: November 5, 2009
    Inventors: Benjamin FRYDMAN, Laurence J. Maron, Linda Clifford
  • Patent number: 7601876
    Abstract: Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, especially A? amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, AA/SAA amyloidosis, such as observed in systemic AA amyloidosis and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: October 13, 2009
    Assignee: Proteotech, Inc.
    Inventors: Alan D. Snow, Beth P. Nguyen, Gerardo M. Castillo, Virginia J. Sanders, Thomas P. Lake, Lesley Larsen, Rex T. Weavers, Stephen D. Lorimer, David S. Larsen, David L. Coffen, Charlotte Coffen, legal representative
  • Publication number: 20080293951
    Abstract: Disclosed is a benzonitrile derivative which is useful as a production intermediate for benzylamine derivative represented by the general formula (5) below and s secondary amine derivative represented by the general formula (9) below. Also disclosed are a method for producing such a benzonitrile derivative and a use thereof as a bactericide. Specifically disclosed are a novel benzonitrile derivative represented by the general formula (1) below, a salt thereof, a production method thereof, and a use thereof as a pharmaceutical intermediate or a bactericide. [Chemical formula 1] (5) (In the formula, n represents an integer of 0-3, and R1 represents a hydrogen, a linear or branched alkyl group having 1-6 carbon atoms or the like.) [Chemical formula 2] (9) (In the formula, n and R1 are a defined above, and R4 represents a hydrogen, a linear or branched alkl group having 1-6 carbon atoms or the like.
    Type: Application
    Filed: August 22, 2006
    Publication date: November 27, 2008
    Inventors: Hideki Iwama, Junko Sudo, Susumu Shimizu, Masataka Katohno, Masashi Yamamoto, Shigeru Suzuki, Hiroshi Hoshino, Nanako Kuruhara
  • Publication number: 20080234502
    Abstract: [Problem] To provide a production method of optically active epoxy compound, and a complex used for the production method and a production method of the complex. [Means for solving the problem] The skeleton that is necessary for expressing a high catalyst activity of optically active titanium salan complex of formulae (1) and (1?) and the substituent that is useful therefor and the position of the substituent are identified, and it is found that optically active epoxy compounds can be produced with a high enantioselectivity and a high chemical yield compared with a case where the prior optically active titanium salan complex is used. The production method comprises subjecting a prochiral compound (formula (4), (5) or (6)) having carbon-carbon double bond in the molecule to asymmetric epoxidation to produce an optically active epoxy compound (formula (7), (8) or (9)). The present invention relates also to a complex used for the production method and a production method of the complex.
    Type: Application
    Filed: November 8, 2007
    Publication date: September 25, 2008
    Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Shoichi Kondo, Kazuhiro Matsumoto, Yuji Sawada, Tsutomu Katsuki
  • Publication number: 20070236137
    Abstract: The present invention relates to aromatic amine derivatives having a specific structure; and organic electroluminescent devices comprising a cathode, an anode and one or plural organic thin film layers including at least a light emitting layer which are sandwiched between the cathode and the anode wherein at least one of the organic thin film layers contains the above aromatic amine derivatives in the form of a single substance or a component of a mixture. There are provided the organic electroluminescent devices exhibiting a long life and a high efficiency of light emission which are capable of emitting a blue light having a high color purity, as well as the aromatic amine derivatives capable of realizing such organic electroluminescent devices.
    Type: Application
    Filed: March 2, 2007
    Publication date: October 11, 2007
    Applicant: Idemitsu Kosan Co., Ltd.
    Inventor: Masakazu FUNAHASHI
  • Patent number: 7179926
    Abstract: The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts and solvates, their pharmaceutical compositions, and their use in treating disorders associated with an excess or imbalance of tachykinins or serotonin or both.
    Type: Grant
    Filed: July 25, 2005
    Date of Patent: February 20, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yazhong Huang, Shuanghua Hu, Andrew P. Degnan
  • Patent number: 7060851
    Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: June 13, 2006
    Assignee: G.D. Searle & Co.
    Inventors: John S Ng, Claire A Przybyla, Shu-Hong Zhang
  • Patent number: 7022882
    Abstract: Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity for NMDA receptors, the agents exert an open channel block on NMDA receptors, and protect neuronal cells containing such receptors from excitatoxic cell death.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: April 4, 2006
    Assignee: The Regents of the University of California
    Inventors: Kwok-Keung Tai, Sylvie E. Blondelle, Richard A. Houghten, Mauricio Montal