Additional Amino Nitrogen Attached Directly Or Indirectly To The Acyclic Carbon Or Chain By Acyclic Nonionic Bonding Patents (Class 564/372)
-
Patent number: 9205455Abstract: The present invention develops a method of treating metallic or plastic substrates to form mirror finish. After several pre-treatment steps to modify the surface situation of the substrate, whether for metallic or plastic material, to enhance the adhesion of above coating layers, a layer of mirror finish will be applied, with the function of decoration shown with metal appearance and glossy. A changeable topcoat will be coated to protect below mirror finish layer and achieve colorful decoration. All materials and processing steps are environmentally friendly, and involved without expensive facilities.Type: GrantFiled: December 8, 2014Date of Patent: December 8, 2015Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITEDInventors: Jianying Miao, Wei Li, Shing Hang Ng
-
Publication number: 20150011775Abstract: The present application provides for a compound of Formula I, or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.Type: ApplicationFiled: May 2, 2014Publication date: January 8, 2015Applicant: Gilead Sciences, Inc.Inventors: Manoj C. DESAI, Allen Yu HONG, Hongtao LIU, Randall W. VIVIAN, Lianhong XU
-
Patent number: 8859813Abstract: The present invention relates to salts having uronium cations and to a process for preparing same comprising alkylating urea C(O)(NR2)2 using an ester ARo.Type: GrantFiled: August 21, 2012Date of Patent: October 14, 2014Assignee: Merck Patent GmbHInventors: Nikolai (Myloka) Ignatyev, Urs Welz-Biermann, German Bissky, Helge Willner, Andriy Kucheryna
-
Patent number: 8853278Abstract: Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.Type: GrantFiled: November 8, 2013Date of Patent: October 7, 2014Assignees: Curza Global, LLC, University of Utah Research FoundationInventors: Ryan Looper, Dustin Williams, Sujeevini Jeyapalina, Travis Haussener, Paul R. Sebahar, Hari Kanna Reddy
-
Publication number: 20130267543Abstract: The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, mixtures (including both R and S enantiomeric forms and racemic mixtures thereof), and pharmaceutical Formulations thereof. In particular, the present invention provides compounds capable of facilitating HSF1 homotrimerization, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with irregular HSF1 activity.Type: ApplicationFiled: November 8, 2011Publication date: October 10, 2013Applicants: CHAPERONE THERAPEUTICS, INC., DUKE UNIVERSITYInventors: Dennis J. Thiele, Daniel W. Neef, Jose S. Mendoza
-
Patent number: 8501997Abstract: The present invention discloses both amine compositions and amine-epoxy compositions containing N,N?-dimethyl-meta-xylylenediamine. A novel process for producing amines such as N,N?-dimethyl-meta-xylylenediamine, and structurally similar amines, is also disclosed.Type: GrantFiled: August 25, 2008Date of Patent: August 6, 2013Assignee: Air Products and Chemicals, Inc.Inventors: Gamini Ananda Vedage, John Anthony Marsella
-
Publication number: 20130197223Abstract: Among other things, the present invention encompasses methods of synthesizing salicylaldehyde derivatives comprising the steps of: a) providing salicylaldehyde or a derivative thereof, b) forming an anhydro dimer of the provided salicylaldehyde compound, c) performing one or more chemical transformations on the anhydro dimer and d) hydrolyzing the anhydro dimer to provide a salicylaldehyde derivative different from that provided in step (a).Type: ApplicationFiled: September 22, 2011Publication date: August 1, 2013Applicant: NOVOMER, INC.Inventors: Jay J. Farmer, Gabriel E. Job
-
Patent number: 8436205Abstract: The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.Type: GrantFiled: October 22, 2009Date of Patent: May 7, 2013Assignee: Actelion Pharmaceuticals Ltd.Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg
-
Publication number: 20120214786Abstract: This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7, R8 have meanings given in the description.Type: ApplicationFiled: August 17, 2011Publication date: August 23, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Henning PRIEPKE, Henri DOODS, Raimund KUELZER, Roland PFAU, Dirk STENKAMP, Benjamin PELCMAN, Robert ROENN
-
Patent number: 8158827Abstract: Disclosed are cationic lipid compounds and compositions of lipid aggregates for delivery of macromolecules and other compounds into cells. The compounds can be used alone or in combination with other compounds to prepare liposomes and other lipid aggregates suitable for transfection or delivery of compounds to target cells, either in vitro or in vivo. The compounds are preferably polycationic and preferably form highly stable complexes with various anionic macromolecules, particularly polyanions such as nucleic acids. These compounds have the property, when dispersed in water, of forming lipid aggregates which associate strongly, via their cationic portion, with polyanions. Also disclosed are intermediates for preparing the compound and compositions of the invention and methods of using the compounds to introduce other compounds into cells.Type: GrantFiled: January 14, 2009Date of Patent: April 17, 2012Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Publication number: 20120078016Abstract: Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution.Type: ApplicationFiled: January 28, 2011Publication date: March 29, 2012Inventors: John Michael GARDLIK, Garry Steven Garrett, Bryan Patrick Murphy, Guiru Zhang, Robert Edward Shumate, James S. Anderson
-
Publication number: 20110207815Abstract: The invention relates to compounds of Formula (I) wherein R1, R2, R3, R4, R5, m and n are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.Type: ApplicationFiled: October 22, 2009Publication date: August 25, 2011Inventors: Kurt Hilpert, Francis Hubler, Dorte Renneberg
-
Publication number: 20100197800Abstract: The invention relates to the treatment and/or prevention of age-related hearing loss (presbycusis) with a modulator of a metabotropic glutamate receptor 7 (mGluR7).Type: ApplicationFiled: April 23, 2008Publication date: August 5, 2010Inventors: Richard Friedman, Dietrich Stephan, Guido (Guy) Van Camp, Matthew J. Huentelman, Lut Van Laer
-
Publication number: 20100130505Abstract: Disclosed are compositions and methods for treating diseases associated with G protein ?? subunit activity.Type: ApplicationFiled: April 28, 2008Publication date: May 27, 2010Applicant: University of RochesterInventors: Alan V. Smrcka, Burns C. Blaxall, Jean M. Bidlack
-
Publication number: 20100048954Abstract: The present invention discloses both amine compositions and amine-epoxy compositions containing N,N?-dimethyl-meta-xylylenediamine. A novel process for producing amines such as N,N?-dimethyl-meta-xylylenediamine, and structurally similar amines, is also disclosed.Type: ApplicationFiled: August 25, 2008Publication date: February 25, 2010Applicant: Air Products and Chemicals, Inc.Inventors: Gamini Ananda Vedage, John Anthony Marsella
-
Publication number: 20090326274Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.Type: ApplicationFiled: June 26, 2009Publication date: December 31, 2009Applicant: BIAL - PORTELA & CA, .S.A.Inventors: Beatriz Dominguez, Antonio Zanotti-Gerosa, Gabriela Alexandra Grasa, Jonathan Alan Medlock
-
Publication number: 20090270510Abstract: The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.Type: ApplicationFiled: December 21, 2005Publication date: October 29, 2009Applicant: GLAXO GROUP LIMITEDInventors: Daniel Marcus Bradley, Clive Leslie Branch, Wai Ngor Chan, Steven Coulton, Martin Leonard Gilpin, Andrew Jonathan Harris, Justine Yeun Quai Lai, Jacqueline Anne Macritchie, Howard Robert Marshall, David John Nash, Roderick Alan Porter, Simone Spada, Kevin Michael Thewlis, Simon Edward Ward
-
Patent number: 7601872Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: January 21, 2005Date of Patent: October 13, 2009Assignee: Life Technologies CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Patent number: 7588721Abstract: A solid xylylenediamine solidified in a container is extremely excellent in storage stability as compared with a liquid xylylenediamine, and is less degraded by discoloration even when stored in an atmosphere containing oxygen. By charging a liquid xylylenediamine into a container, solidifying the liquid xylylenediamine into a solid xylylenediamine in the container under cooling without delay after the charging, and storing the solid xylylenediamine in the container while maintaining the xylylenediamine in a solid state, the xylylenediamine is stored for a long period of time without causing deterioration of quality such as discoloration.Type: GrantFiled: August 29, 2007Date of Patent: September 15, 2009Assignee: Mitsubishi Gas Chemical Company, Inc.Inventors: Kazumi Tanaka, Kazuhiko Amakawa
-
Publication number: 20090058282Abstract: The present invention relates to a compound of general formula (I) and a method of using the compound. The present invention relates also to an organic EL device including a pair of electrodes and a luminescent layer, sandwiched between the pair of electrodes, containing a luminescent material. The luminescent material contains the compound. The present invention relates also to a method of manufacturing the organic EL device using the compound and a method of using such an organic EL device. The compound provided by the present invention is a novel luminescent component which singly emits white light.Type: ApplicationFiled: November 28, 2006Publication date: March 5, 2009Inventors: Zhaomin Hou, Yu Liu
-
Patent number: 7470817Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)I, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, and wType: GrantFiled: December 28, 2006Date of Patent: December 30, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Publication number: 20080214871Abstract: A process for preparing a xylylenediamine by heterogeneously catalyzed hydrogenation of a phthalonitrile, wherein the hydrogenation is carried out in the presence of a cobalt skeletal catalyst, of an alkali metal hydroxide and of an alcohol and/or ether as the solvent, at an absolute pressure in the range from 1 to 100 bar and a temperature in the range from 40 to 150° C.Type: ApplicationFiled: January 19, 2006Publication date: September 4, 2008Applicant: BASF AktiengesellschaftInventors: Martin Ernst, Thilo Hahn, Kirsten Wenz, Randolf Hugo, Johann-Peter Melder
-
Publication number: 20080161609Abstract: Processes for preparing a xylylenediamine by continuous hydrogenation, wherein the processes comprise: introducing a liquid circulation stream comprising a phthalonitrile and ammonia into a reactor to continuously hydrogenate the phthalonitrile in the presence of a heterogenous catalyst and the ammonia such that a reactor effluent comprising the xylylenediamine is formed; drawing off a portion of the reactor effluent to provide a first recycle stream; mixing at least a portion of the first recycle stream in a mixing unit with liquid ammonia and fresh phthalonitrile in solid or molten form to provide a second recycle stream; and recycling the second recycle stream to the liquid circulation stream, or wherein the second recycle stream and any remaining unmixed portion of the first recycle stream are both recycled to the liquid circulation stream.Type: ApplicationFiled: July 27, 2006Publication date: July 3, 2008Applicant: BASF AktiengesellschaftInventors: Randolf Hugo, Kirsten Dahmen, Sabine Huber
-
Publication number: 20080154061Abstract: A process for preparing a xylylenediamine by heterogeneously catalyzed hydrogenation of a phthalonitrile, wherein the hydrogenation is carried out in the presence of a nickel catalyst, of water, of an alkali metal hydroxide and of an ether as a solvent, at an absolute pressure in the range from 1 to 100 bar, at a temperature in the range from 40 to 150° C. and without addition of ammonia.Type: ApplicationFiled: February 23, 2006Publication date: June 26, 2008Applicant: BASF AktiengesellschaftInventors: Martin Ernst, Kirsten Wenz, Randolf Hugo, Johann-Peter Melder, Thilo Hahn
-
Publication number: 20080091049Abstract: The invention relates to a method for producing xylylenediamine, comprising the following steps: ammonoxidation of xylol to form phthalodinitrile and hydrogenation of the phthalodinitrile, whereby the vaporous product of the ammonoxidation stage is directly brought into contact with a liquid organic solvent or with melted phthalodinitrile (quench); constituents having a boiling point lower than that of phthalodinitrile (low boilers) are partially or completely separated out from the obtained quench solution or suspension or phthalodinitrile melt, and; before the hydrogenation of the phthalodinitrile, no products having a boiling point higher than that of phthalodinitrile (high boilers) are separated out.Type: ApplicationFiled: September 4, 2004Publication date: April 17, 2008Applicant: BASF AktiengesellschaftInventors: Randolf Hugo, Sabine Jourdan, Kirsten Wenz, Thomas Preisss, Alexander Weck
-
Patent number: 7351389Abstract: Novel metal-chelate complexes comprising aminocarboxylate ligands including substituted aromatic amide moieties, such as those having the formula wherein R13, A1, R1 and R2 are as defined herein, are disclosed.Type: GrantFiled: October 13, 2004Date of Patent: April 1, 2008Assignee: Bracco International B.V.Inventors: Radhakrishna K. Pillai, Sang I. Kang, Edmund R. Marinelli, Ramachandran S. Ranganathan, Michael F. Tweedle
-
Publication number: 20080039527Abstract: The present invention provides compounds useful in inhibiting protein kinase B (PKB/Akt). Compositions comprising such compounds and their use are also provided.Type: ApplicationFiled: September 9, 2004Publication date: February 14, 2008Inventors: Rudiger Woscholski, Helen Claire Hailes, Macba Golda Numbere
-
Patent number: 7323594Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)l, or {(CH2)i-Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by -X1-L?-X2-Z or -Z; R1-R6, independently of one another, are selected from the group consisting of H, —(CH2)p-D-Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: December 28, 2006Date of Patent: January 29, 2008Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Patent number: 7211695Abstract: Disclosed are multibinding compounds which are ?2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: April 10, 2006Date of Patent: May 1, 2007Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 7166745Abstract: Disclosed are compounds capable of facilitating transport of biologically active agents or substances into cells having the general structure: wherein Q is selected from the group consisting of N, O and S; L is any bivalent organic radical capable of linking each Q, such as C, CH, (CH2)1, or {(CH2)i—Y—(CH2)j}k, wherein Y is selected from the group consisting of CH2, an ether, a polyether, an amide, a polyamide, an ester, a sulfide, a urea, a thiourea, a guanidyl, a carbamoyl, a carbonate, a phosphate, a sulfate, a sulfoxide, an imine, a carbonyl, and a secondary amino group and wherein Y is optionally substituted by —X1—L?—X2—Z or —Z; R1–R6, independently of one another, are selected from the group consisting of H, —CH2)p—D—Z, an alkyl, an alkenyl, an aryl, and an alkyl or alkyl ether optionally substituted by one or more of an alcohol, an aminoalcohol, an amine, an amide, an ether, a polyether, a polyamide, an ester, a mercaptan, an alkylthio, a urea, a thiourea, a guanidyl, or a carbamoyl group, andType: GrantFiled: November 12, 1999Date of Patent: January 23, 2007Assignee: Invitrogen CorporationInventors: Yongliang Chu, Malek Masoud, Gulilat Gebeyehu
-
Patent number: 7067553Abstract: The present invention relates to thiourea compounds and the pharmaceutical compositions containing the same, and particularly, to novel thiourea compounds as an antagonist against vanilloid receptor (VR) and the pharmaceutical compositions thereof. As diseases associated with the activity of vanilloid receptor, pain, acute pain, chronic pain, neuropathic pain, post-operative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurodegeneration, neurotic skin disorder, stroke, urinary bladder hypersensitiveness, irritable bowel syndrome, a respiratory disorder such as asthma or chronic obstructive pulmonary disease, irritation of skin, eye or mucous membrane, fervescence, stomach-duodenal ulcer, inflammatory bowel disease and inflammatory diseases can be enumerated. The present invention provides a pharmaceutical composition for prevention or treatment of these diseases.Type: GrantFiled: August 20, 2001Date of Patent: June 27, 2006Assignee: Pacific CorporationInventors: Young Ger Suh, Uh Taek Oh, Hee Doo Kim, Jee Woo Lee, Hyeung Geun Park, Young Ho Park, Jung Bum Yi
-
Patent number: 7022882Abstract: Neuroprotectant agents are provided which do not contain peptides and axe protected from the degradation that limits the use of peptide-based drugs in systemic circulation. With great selectivity for NMDA receptors, the agents exert an open channel block on NMDA receptors, and protect neuronal cells containing such receptors from excitatoxic cell death.Type: GrantFiled: October 5, 2001Date of Patent: April 4, 2006Assignee: The Regents of the University of CaliforniaInventors: Kwok-Keung Tai, Sylvie E. Blondelle, Richard A. Houghten, Mauricio Montal
-
Patent number: 6894192Abstract: In the process of the present invention for producing a xylylenediamine by a liquid-phase hydrogenation of a dicyanobenzene in the presence of a catalyst, the catalyst having its activity decreased during the course of use in the hydrogenation is reactivated and a pressure drop through a fixed bed catalyst layer is got rid of, thereby regenerating the catalyst for reuse in the subsequent hydrogenation of the dicyanobenzene to produce the xylylenediamine. The catalyst is regenerated by brought into contact with a hydrogen-containing gas under controlled temperature conditions.Type: GrantFiled: August 20, 2003Date of Patent: May 17, 2005Assignee: Mitsubishi Gas Chemical Company, Inc.Inventor: Kazuhiko Amakawa
-
Patent number: 6872852Abstract: Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury.Type: GrantFiled: March 23, 2001Date of Patent: March 29, 2005Assignee: MediQuest Therapeutics, Inc.Inventor: Mark R. Burns
-
Patent number: 6780998Abstract: The oxidation hair dye precursor composition contains from 0.005 to 20.0 percent by weight of one or more coupler compounds and from 0.005 to 20.0 percent by weight of one or more developer compounds. The one or more developer compounds include at least one substituted 2-aminoalkyl-1,4-diaminobenzene compound of the formula (I): New substituted 2-aminoalkyl-1,4-diaminobenzene compounds of formula (I) are described.Type: GrantFiled: April 17, 2002Date of Patent: August 24, 2004Assignee: Wella AktiengesellschaftInventors: Laurent Chassot, Hans-Juergen Braun
-
Patent number: 6713651Abstract: Disclosed are multibinding compounds which are &bgr;2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: November 1, 2000Date of Patent: March 30, 2004Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6683115Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: August 21, 2001Date of Patent: January 27, 2004Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6649587Abstract: Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions comprising these conjugates. Methods of using these conjugates in the treatment of prostate diseases are also provided.Type: GrantFiled: April 27, 2000Date of Patent: November 18, 2003Assignee: SLIL Biomedical CorporationInventors: Benjamin Frydman, Laurence J. Marton
-
Patent number: 6596863Abstract: Process for producing a nitroetheneamine derivative or its stereoisomer, its tautomer or a salt thereof comprising reacting a compound of the formula with a compound of the formula R6—CH2NO2 to obtain a compound of the formula and reacting the resulting compound with a compound of the formulaType: GrantFiled: April 29, 2002Date of Patent: July 22, 2003Assignee: Ishihara Sangyo Kaisha, Ltd.Inventors: Fuminori Kato, Keizo Miyata, Hirohiko Kimura, Kazuhiro Yamamoto, Hiroyuki Ikegami, Hiromi Takeo
-
Patent number: 6593497Abstract: The present invention is directed to multibinding compounds which are &bgr;2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such asthma, bronchitis, and the like. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: February 14, 2000Date of Patent: July 15, 2003Assignee: Theravance, Inc.Inventors: Seok-Ki Choi, Edmund J. Moran
-
Publication number: 20030109556Abstract: Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: 1Type: ApplicationFiled: April 12, 2002Publication date: June 12, 2003Applicant: The Procter & Gamble CompanyInventors: Wieslaw Adam Mazur, Xinrong Tian, Xiufeng Eric Hu, Frank Hallock Ebetino
-
Patent number: 6576793Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma and bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: August 14, 2000Date of Patent: June 10, 2003Assignee: Theravance, Inc.Inventors: Edmund J. Moran, John H. Griffin, Seok-Ki Choi
-
Patent number: 6541669Abstract: Disclosed are multibinding compounds which are &bgr;2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.Type: GrantFiled: June 2, 1999Date of Patent: April 1, 2003Assignee: Theravance, Inc.Inventors: Edmund J. Moran, Seok-Ki Choi
-
Patent number: 6506920Abstract: Olefins such as ethylene and propylene may be polymerized by using as catalysts novel selected transition metal complexes of bis(carboximidamidatonates) in which the carboximidamidatonate groups are connected together through covalent bonds by a bridging group. The resulting polymers are useful as molding and extrusion resins.Type: GrantFiled: April 2, 2001Date of Patent: January 14, 2003Assignee: E. I. du Pont de Nemours and CompanyInventors: Steven Dale Ittel, Edward Bryan Coughlin, Ying Wang
-
Publication number: 20020165231Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.Type: ApplicationFiled: November 14, 2001Publication date: November 7, 2002Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
-
Publication number: 20020143068Abstract: Polyamines having the formula: 1Type: ApplicationFiled: December 14, 2001Publication date: October 3, 2002Inventor: Raymond J. Bergeron
-
Patent number: 6451792Abstract: A medical composition containing, as an active constituent, a nitroetheneamine derivative represented by the formula (I): wherein the substituents are as defined in the disclosure, its stereoisomers, its tautomers or a salt thereof.Type: GrantFiled: March 20, 2001Date of Patent: September 17, 2002Assignee: Ishihara Sangyo Kaisha Ltd.Inventors: Fuminori Kato, Keizo Miyata, Hirohiko Kimura, Kazuhiro Yamamoto, Hiroyuki Ikegami, Hiromi Takeo
-
Publication number: 20020049256Abstract: 1Type: ApplicationFiled: July 18, 2001Publication date: April 25, 2002Inventor: Raymond J. Bergeron
-
Patent number: 6365708Abstract: This invention relates to novel polyamines which are the reaction product of A) at least one nonaromatic diamine containing from 2 to 40 carbon atoms, wherein the amine groups are primary amine groups; and B) at least one epihalohydrin of the formula where R is hydrogen or methyl and X is chlorine or bromine; and the coatings resulting from the reaction between the above reaction product and nonaromatic epoxy resins.Type: GrantFiled: December 20, 1999Date of Patent: April 2, 2002Assignee: Cognis CorporationInventors: Shailesh Shah, Anbazhagan Natesh, Joseph Mulvey, Ronald C. LaFreeda, Gaetano D. DeAngelis, Ronald T. Cash, Jr.
-
Publication number: 20010056106Abstract: The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonists of the contractile smooth muscle response to those ligands.Type: ApplicationFiled: March 9, 2001Publication date: December 27, 2001Inventors: Robert H. Chen, Min A. Xiang