Bicyclo Ring System Patents (Class 564/428)
  • Patent number: 10017458
    Abstract: The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by CPCRs and/or RSKs.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: July 10, 2018
    Assignee: University of Florida Research Foundation, Incorporated
    Inventor: Raymond G. Booth
  • Patent number: 9682919
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: June 20, 2017
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • Patent number: 9439877
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Grant
    Filed: July 9, 2015
    Date of Patent: September 13, 2016
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • Patent number: 9127016
    Abstract: Compounds that stimulate fibroblast growth factor production, and thus cell growth are provided. Also provided are compositions comprising the compounds and methods of using the compounds. The compounds can be used to treat wounds, to expand cell populations, such as hematopoietic cells, or to grow tissue in vitro, among other uses.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: September 8, 2015
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Billy W. Day, Waikok Michael Tsang, Vasiliy N. Korotchenko
  • Patent number: 9040725
    Abstract: The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof; provided that the compound is other than or a pharmaceutically acceptable salt thereof. The claimed compounds are useful for the treatment of a disease, the treatment of which is affected, mediated or facilitated by activating the GHS1A-r receptor. The invention also relates to pharmaceutical compositions thereof and processes for the preparation thereof.
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 26, 2015
    Assignee: Janssen Pharmaceutica, NV
    Inventors: Bruno Schoentjes, Alain Philippe Poncelet, Julien Georges Pierre-Olivier Doyon, Joannes Theodorus Maria Linders, Lieven Meerpoel, Luc August Laurentius Ver Donck
  • Publication number: 20150141384
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I; and methods for treating or preventing neurological degenerative disorders, may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of Alzheimer's disease, Lewy body disease, Huntington's disease, Amyotrophic lateral sclerosis (ALS) and Parkinson's disease.
    Type: Application
    Filed: June 23, 2013
    Publication date: May 21, 2015
    Inventor: Mahesh KANDULA
  • Publication number: 20150141697
    Abstract: A triarylamine derivative represented by a general formula (G1) given below is provided. Note that in the formula, Ar represents either a substituted or unsubstituted phenyl group or a substituted or unsubstituted biphenyl group; ? represents a substituted or unsubstituted naphthyl group; ? represents either hydrogen or a substituted or unsubstituted naphthyl group; n and m each independently represent 1 or 2; and R1 to R8 each independently represent any of hydrogen, an alkyl group having 1 to 6 carbon atoms, or a phenyl group.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Applicant: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Harue Osaka, Takahiro USHIKUBO, Nobuharu OHSAWA, Satoshi SEO, Tsunenori SUZUKI
  • Publication number: 20150133646
    Abstract: Disclosed herein is a method of activating a compound for a chemical reaction comprising functionalizing a compound with a redox auxiliary group and oxidizing the redox auxiliary group that is bonded to the compound, thereby activating the compound, wherein the activated compound undergoes a chemical reaction to form a product and the oxidation of the redox auxiliary group is reversible. Methods of making and using these materials are also disclosed.
    Type: Application
    Filed: October 31, 2014
    Publication date: May 14, 2015
    Inventors: Silas Blackstock, Lester Gray, Melody Kelley, Carl Saint-Louis
  • Patent number: 9024071
    Abstract: The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.
    Type: Grant
    Filed: May 5, 2010
    Date of Patent: May 5, 2015
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Raymond G. Booth
  • Publication number: 20150119241
    Abstract: The present invention relates to novel 1-methyl-3-dihalogenomethyl-5-halogenopyrazole(thio)indanyl carbox-amides, to processes for preparing these compounds, to compositions comprising these compounds, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials.
    Type: Application
    Filed: May 6, 2013
    Publication date: April 30, 2015
    Inventors: Pierre-Yves Coqueron, Simon Maechling, Mazen Es-Sayed, Pierre Wasnaire, Ulrike Wachendorff-Neumann, David Bernier, Lionel Carles, Christophe Dubost, Jean-Pierre Vors, Stéphane Brunet, Hélène Lachaise, Pierre Genix
  • Publication number: 20150115204
    Abstract: A polymer compound is provided having constitutional units of formula (1) and formula (2), and a constitutional unit of formula (3) and/or (4?): wherein Ar1 to Ar4, Ar20, Ar30? and Ar40 represent arylene groups or the like; Ar5 to Ar7 represent aryl groups or the like; Ar8 represents (2+p)-valent aromatic hydrocarbon group or the like; Ar10 represents (2+n)-valent aromatic hydrocarbon group or the like; R1 represents alkyl group or the like; La, Lb, Lg and Lh represent alkylene groups or the like; LA and LD represent oxygen atoms or the like; Q1 represents monovalent crosslinkable group; Q2? to Q4? represent monovalent crosslinkable groups or the like; x, y, c, nA and nD represent 0 or 1; p represents integer of 1 or greater.; na and ng represent integer of 0 to 3; nb and nh represent integer of 0 to 12; and n represents integer of 1 to 4.
    Type: Application
    Filed: March 26, 2013
    Publication date: April 30, 2015
    Applicants: CAMBRIDGE DISPLAY TECHNOLOGY LIMITED, SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Chizu Sekine, Satoshi Mikami, Makoto Anryu, Hidenobu Kakimoto, Annette Regine Steudel, Martin John Humphries, Kiran Timothy Kamtekar, Elena Hojas Garcia, Sophie Heidenhain, Ruth Pegington
  • Publication number: 20150073177
    Abstract: Methods are provided to inhibit proliferation of Trypanosoma cruzi with imido-substituted 1,4-naphthoquinones, including novel compounds. Administering an imido-substituted 1,4-naphthoquinone can be used to provide prophylaxis or treatment to a patient in need of treatment against Chagas disease.
    Type: Application
    Filed: July 27, 2012
    Publication date: March 12, 2015
    Applicant: HOWARD UNIVERRSITY
    Inventors: Oladapo Bakare, Clarence M. Lee, Yakini Brandy, Mozna Husein Khraiwesh
  • Patent number: 8962853
    Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: February 24, 2015
    Assignee: Life Technologies Corporation
    Inventors: Ching-Ying Cheung, Diane Gray, Stephen Yue
  • Publication number: 20150045560
    Abstract: Described herein are heterocyclic organic compounds of following formulae: More specifically, described herein are fused heterocyclic naphthalene compounds, polymers based on fused heterocyclic naphthalene compounds, methods for making these compounds, and uses thereof. The compounds described have improved polymerization and stability properties that allow for improved material processibility for use as organic semiconductors (OSCs).
    Type: Application
    Filed: March 28, 2013
    Publication date: February 12, 2015
    Inventors: Mingqian He, Jieyu Hu, Weijun Niu, Adama Tandia
  • Publication number: 20150045445
    Abstract: The subject invention provides a pharmaceutical composition containing N-propargyl-1(R)-aminoindan or a pharmaceutically acceptable salt thereof, and a compound of 3-keto-N-propargyl-1-aminoindan or a salt thereof.
    Type: Application
    Filed: October 23, 2014
    Publication date: February 12, 2015
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Anton Frenkel, Ramy Lidor-Hadas, Eliezer Bahar
  • Patent number: 8951831
    Abstract: The present invention relates to a new binaphthalene derivative, a preparation method thereof, and an organic electronic device using the same. The binaphthalene derivative according to the present invention can perform functions of hole injection and transportation, electron injection and transportation, or light emission in an organic electronic device including an organic light-emitting device, and the device according to the present invention has excellent characteristics in terms of efficiency, drive voltage and stability, and in particular excellent effects such as a low voltage and a long life time.
    Type: Grant
    Filed: February 6, 2014
    Date of Patent: February 10, 2015
    Assignee: LG Chem, Ltd.
    Inventors: Jae Soon Bae, Dae Woong Lee, Dong Hoon Lee, Jae Chol Lee, Jun Gi Jang
  • Publication number: 20150038744
    Abstract: The subject invention provides crystalline R(+)-N-propargyl-1-aminoindan, pharmaceutical compositions and methods of manufacture thereof.
    Type: Application
    Filed: August 14, 2014
    Publication date: February 5, 2015
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Anton Frenkel, Tamas Koltai
  • Publication number: 20150030539
    Abstract: This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).
    Type: Application
    Filed: July 21, 2014
    Publication date: January 29, 2015
    Applicant: PIRAMAL IMAGING SA
    Inventors: Lutz LEHMANN, Andrea THIELE, Tobias HEINRICH, Thomas BRUMBY, Christer HALLDIN, Balazs GULYAS, Sangram NAG
  • Publication number: 20150031768
    Abstract: Methods of halogenating a carbon containing compound having an sp3 C—H bond are provided. Methods of fluorinating a carbon containing compound comprising halogenation with Cl or Br followed by nucleophilic substitution with F are provided. Methods of direct oxidative C—H fluorination of a carbon containing compound having an sp3 C—H bond are provided. The halogenated products of the methods are provided.
    Type: Application
    Filed: October 9, 2014
    Publication date: January 29, 2015
    Inventors: John T. Groves, Wei Liu, Xiongyi Huang
  • Publication number: 20150018548
    Abstract: A process for producing N-methyl or N,N-dimethyl amines, which comprises using amine compound, nitro-containing compound or nitrile compound as a starting material, carbon dioxide as a methylating agent and hydrogen gas as a reducing agent, and allowing them to react in a sealed reactor for 6 to 48 h in a reaction medium at a reaction temperature of 80 to 180 ° C. in the presence of a composite catalyst, so as to provide N-methyl or N,N-dimethyl amines. The process of the present invention is simple and under relative mild reaction conditions. By means of the process of the invention, the target products can be prepared at low cost with a high yield. The catalysts used have a high catalytic activity and can be separated from the reaction system simply and reused. Furthermore, the whole process of the present invention is environmental-friendly and facilitates the cycling use of carbon dioxide.
    Type: Application
    Filed: September 27, 2013
    Publication date: January 15, 2015
    Applicant: Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences
    Inventors: Feng SHI, Xinjiang Cui, Hangkong Yuan, Yan Zhang, Youquan Deng
  • Publication number: 20150005388
    Abstract: A method of treating or preventing emesis through the administration of an effective dosage of a 2-(amino)tetralin compound in which one of the S or R enantiomers of the 2-(amino) tetralin compound is present in the composition in excess of the other enantiomer, and compositions comprising such a 2-(amino)tetralin compound in which the ratio of the S and R enantiomers is at least 2:1.
    Type: Application
    Filed: July 30, 2014
    Publication date: January 1, 2015
    Inventors: David Helton, James Lucot
  • Publication number: 20140364506
    Abstract: The subject invention provides deuterated rasagiline, its salts and uses.
    Type: Application
    Filed: June 20, 2014
    Publication date: December 11, 2014
    Applicant: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
    Inventors: Elizer Bahar, Anton Frenkel, Victor Piryatinsky
  • Publication number: 20140343113
    Abstract: The present invention relates to fungicidal N-bicycloalkyl and N-tricycloalkyl pyrazole-4-(thio)carboxamide derivatives of formula (I), wherein T represents 0 or S; n represents 0 or 1; and B represents where the bond marked by * is attached to the (CZ2Z3)n-N amide moiety, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.
    Type: Application
    Filed: November 29, 2012
    Publication date: November 20, 2014
    Inventors: Jürgen Benting, Stéphane Brunet, Pierre-Yves Coqueron, Pierre Cristau, Peter Dahmen, Philippe Desbordes, Stéphanie Gary, Jörg Greul, Hélène Lachaise, Jan-Peter Schmidt, Philippe Rinolfi, Jean-Pierre Vors, Ulrike Wachendorff-Neumann
  • Publication number: 20140309459
    Abstract: Present invention relates to a method of preparing a chiral ?- or ?-substituted ketone from the corresponding ?- or ?-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula (II), (IV) or (VI), respectively, the method comprising reacting the aldehyde of formula (II), (IV) or (VI) in the presence of an amine, oxygen and an organic solvent, wherein the reaction is carried out in the absence of a metal-based catalyst or a metal-based oxidant, wherein: R is H, a substituted or unsubstituted C1-C10 alkyl, substituted or unsubstituted C2-C15 alkenyl, substituted or unsubstituted C2-C15 alkynyl, substituted or unsubstituted C3-C15 cycloalkyl, substituted or unsubstituted C3-C15 cycloalkenyl, substituted or unsubstituted C3-C15 heterocycloalkyl, substituted or unsubstituted C3-C15 heterocycloalkenyl, substituted or unsubstituted C6-C15 aryl, or substituted or unsubstituted C6-C15 heteroaryl; and R? is H, a substituted or unsubstituted C1-C10 alkyl, substitut
    Type: Application
    Filed: December 13, 2012
    Publication date: October 16, 2014
    Inventors: Yonggui Chi, Bhoopendra Tiwari
  • Publication number: 20140275440
    Abstract: A diamine monomer having a large side chain R is provided. The large side chain would interrupt the symmetry and regularity of diamine monomer. The diamine monomer has the general formula shown as formula (V) below: The functional group R includes ?-substitution cycloalkene with at least a tertiary carbon atom, cycloalkene with at least a tertiary carbon atom, cycloalkane with at least a tertiary carbon atom, ?-substitution phenyl, phenyl, ?-substitution naphthalyl, naphthalyl, ?-substitution phenanthrenyl, phenanthrenyl, ?-substitution anthracenyl, anthracenyl, ?-substitution adamantyl, adamantyl, ?-substitution diamantyl and diamantyl.
    Type: Application
    Filed: March 18, 2013
    Publication date: September 18, 2014
    Applicant: UNIMICRON TECHNOLOGY CORP.
    Inventor: HAN-PEI HUANG
  • Publication number: 20140271527
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 18, 2014
    Applicant: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Publication number: 20140242606
    Abstract: The present invention relates to a probe for iFRET and use thereof. Specifically, the present invention relates to a novel probe for iFRET, a method for preparing the probe for iFRET, a method for searching a target protein-specific binding site or a molecule having the binding site using the probe for iFRET, and a method for imaging the target protein using the probe for iFRET. The probe for iFRET according to the present invention utilizes an amino acid in a protein as a fluorescent donor, unlike the conventional FRET method. Therefore, only one fluorescent material is used, and its emission wavelength is distinct from the intrinsic fluorescence of the protein. Thus, high specificity and sensitivity are ensured, and the quantity, activity and mechanism of various proteins can be analyzed in an easy and accurate manner.
    Type: Application
    Filed: June 25, 2012
    Publication date: August 28, 2014
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Sang Jeon Chung, Ju Hwan Kim, Elena Ruchkina, Hyo Jin Kang
  • Patent number: 8809589
    Abstract: The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: August 19, 2014
    Assignee: Generics [UK] Limited
    Inventors: Vinayak Govind Gore, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sinderpal Tank
  • Patent number: 8809590
    Abstract: A method for industrially preparing a nitrogen substituted 6-amino-5,6,7,8-tetrahydronaphthol includes reacting a nitrogen substituted amino-5,6,7,8-tetrahydronaphthol compound of formula (II) with a 2-substituted ethyl sulfonate compound of formula (III) under an alkaline condition and in the presence of a sulfite.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: August 19, 2014
    Assignee: Shan Dong Luye Pharmaceutical Co., Ltd.
    Inventors: Qingguo Meng, Mina Yang, Tao Wang, Qilin Wang, Jun Li, Zheng Ruan
  • Publication number: 20140193338
    Abstract: This invention relates to novel compounds suitable for labelling by 18F and the corresponding 18F labelled compounds themselves, 19F-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by Positron Emission Tomography (PET).
    Type: Application
    Filed: March 20, 2012
    Publication date: July 10, 2014
    Applicant: PIRAMAL IMAGING SA
    Inventors: Andrea Thiele, Georg Kettschau, Tobias Heinrich, Lutz Lehmann, Christer Halldin, Sangram Nag, Andrea Varrone, Balazs Gulyas
  • Publication number: 20140128400
    Abstract: Bridged bicyclic heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Axl. Methods of using the compounds in treating diseases or conditions associated with Axl activity are also disclosed.
    Type: Application
    Filed: January 8, 2014
    Publication date: May 8, 2014
    Applicant: Rigel Pharmaceuticals, Inc.
    Inventors: Rajinder Singh, Sacha Holland, Joane Litvak, Dane Goff, Jing Zhang, Thilo J. Heckrodt
  • Publication number: 20140121380
    Abstract: A method for industrially preparing a nitrogen substituted 6-amino-5,6,7,8-tetrahydronaphthol is disclosed. The method comprises includes reacting a nitrogen substituted amino-5,6,7,8-tetrahydronaphthol compound of formula (II) with a 2-substituted ethyl sulfonate compound of formula (III) under an alkaline condition and in the presence of a sulfite.
    Type: Application
    Filed: June 21, 2012
    Publication date: May 1, 2014
    Applicant: SHAN DONG LUYE PHARMACEUTICAL CO., LTD.
    Inventors: Qingguo Meng, Mina Yang, Tao Wang, Qilin Wang, Jun Li, Zheng Ruan
  • Patent number: 8703973
    Abstract: The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof; provided that the compound is other than ?or a pharmaceutically acceptable salt thereof. The claimed compounds are useful for the treatment of a disease, the treatment of which is affected, mediated or facilitated by activating the GHS1A-r receptor. The invention also relates to pharmaceutical compositions thereof and processes for the preparation thereof.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: April 22, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Bruno Schoentjes, Alain Philippe Poncelet, Julien Georges Pierre-Olivier Doyon, Joannes Theodorus Maria Linders, Lieven Meerpoel, Luc August Laurentius Ver Donck
  • Publication number: 20140100195
    Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
    Type: Application
    Filed: October 5, 2012
    Publication date: April 10, 2014
    Inventors: Richard D. Caldwell, Kevin M. GUCKIAN, Gnanasambandam KUMARA VEL, Wen-Cherng LEE, Edward Yin-Shiang LIN, Xiaogao LlU, Bin MA, Daniel M. SCOTT, Zhan SHl, Jermaine THOMAS, Arthur G. TAVERAS, Guo Zhu ZHENG
  • Patent number: 8674138
    Abstract: The present invention relates to a new binaphthalene derivative, a preparation method thereof, and an organic electronic device using the same. The binaphthalene derivative according to the present invention can perform functions of hole injection and transportation, electron injection and transportation, or light emission in an organic electronic device including an organic light-emitting device, and the device according to the present invention has excellent characteristics in terms of efficiency, drive voltage and stability, and in particular excellent effects such as a low voltage and a long life time.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: March 18, 2014
    Assignee: LG Chem. Ltd.
    Inventors: Jae Soon Bae, Dae Woong Lee, Dong Hoon Lee, Jae Chol Lee, Jun Gi Jang
  • Publication number: 20140057990
    Abstract: This invention provides a convenient method for converting oximes into enamides. The process does not require the use of metallic reagents. Accordingly, it produces the desired compounds without the concomitant production of a large volume of metallic waste. The enamides are useful precursors to amides and amines. The invention provides a process to convert a prochiral enamide into the corresponding chiral amide. In an exemplary process, a chiral amino center is introduced during hydrogenation through the use of a chiral hydrogenation catalyst. In selected embodiments, the invention provides methods of preparing amides and amines that include the 1,2,3,4-tetrahydro-N-alkyl-1-naphthalenamine or 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 27, 2014
    Applicant: SUNOVION PHARMACEUTICALS INC.
    Inventors: Hang Zhao, Stefan G. Koenig, Charles P. Vandenbossche, Surendra Singh, Harold Scott Wilkinson, Roger P. Bakale
  • Patent number: 8653305
    Abstract: Provided are: a compound represented by formula (I): (wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1 to 8 atoms in its main chain; L represents a hydrogen atom or a substituent; X represents amino which may have a substituent(s), or a heterocylcic group which contains at least one nitrogen atom and which may have a substituent(s); n represents 0 to 3, and when n is 2 or more, a plurality of ring A's may be the same or different from one another); a salt, an N-oxide form, a solvate, or a prodrug thereof; and a medicament which includes those. The compound of formula (I) is capable of binding S1P receptors (in particular, EDG-1 and/or EDG-6), and useful for preventing and/or treating rejection in transplantation, autoimmune diseases, allergic diseases, etc.
    Type: Grant
    Filed: September 7, 2011
    Date of Patent: February 18, 2014
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Hiromu Habashita, Shinji Nakade
  • Publication number: 20140027721
    Abstract: Embodiments of the invention are directed to a condensed-cyclic compound represented by Formula 1, and to an organic light-emitting device including the condensed-cyclic compound. The organic light-emitting device may include an organic layer containing the condensed-cyclic compound.
    Type: Application
    Filed: November 14, 2012
    Publication date: January 30, 2014
    Applicant: SAMSUNG DISPLAY CO., LTD.
    Inventors: Soo-Yon Kim, Seok-Hwan Hwang, Young-Kook Kim, Hye-Jin Jung, Jin-O Lim, Sang-Hyun Han, Eun-Jae Jeong, Jun-Ha Park, Eun-Young Lee, Bo-Ra Lee, Jong-Hyuk Lee
  • Patent number: 8629613
    Abstract: Provided are a novel aromatic amine derivative having an asymmetric structure and an organic electroluminescence device in which, an organic thin film layer comprising a single layer or plural layers including at least a light emitting layer is interposed between a cathode and an anode, at least one layer in the above organic thin film layer contains the aromatic amine derivative described above in the form of a single component or a mixed component, whereby molecules are less liable to be crystallized; a yield in producing the organic electroluminescence device is enhanced; and a lifetime is extended.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: January 14, 2014
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Nobuhiro Yabunouchi, Hisayuki Kawamura
  • Patent number: 8623522
    Abstract: Provided are a novel aromatic amine derivative having a specific structure and an organic electroluminescence device in which an organic thin layer comprising a single layer or plural layers including a light emitting layer is interposed between a cathode and an anode, wherein at leas one layer of the above organic thin layer contains the aromatic amine derivative described above in the form of a single component or a mixed component. Thus, the organic electroluminescence device is less liable to be crystallized in molecules, improved in a yield in producing the organic electroluminescence device and extended in a lifetime.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: January 7, 2014
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Nobuhiro Yabunouchi, Tetsuya Inoue
  • Patent number: 8614440
    Abstract: A photoactive layer in organic photodiodes includes organic photoactive dyes, including squaraines with donor-substituted aromatic substituents as the electron donor component, used as an alternative to polymer hold conductors for bulk heterojunctions typically found in the organic active layer of organic photodiodes.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: December 24, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Maria Sramek, Oliver Hayden
  • Publication number: 20130317255
    Abstract: A process for the preparation of Rotigotine (1) and of pharmaceutically acceptable salts thereof, which comprises the reductive amination of an amine of formula 6 with the 2-thienylacetic acid-sodium boron hydride complex and which makes use of hydrobromide 5 as an intermediate The process is advantageous from the industrial point of view in that it allows to obtain Rotigotine with high enantiomeric purity starting from optically active 5,6,7,8-tetrahydro-6-(S)—N-propylamino-1-methoxy-naphthalene (2), avoiding the use of dangerous reactives, the need for difficult chromatographic separation or the formation of by-products. Furthermore, two novel crystalline forms are disclosed.
    Type: Application
    Filed: July 23, 2013
    Publication date: November 28, 2013
    Applicant: FIDIA FARMACEUTICI S.P.A.
    Inventors: Aldo Banfi, Gianluca Belogi, Claudio Fuganti, Roberta Pizzocaro
  • Publication number: 20130310574
    Abstract: A process is disclosed for the preparation of a compound of formula and/or an addition salt of a proton acid, wherein R1 and R2 independently represent alkyl, cycloalkyl, aryl or aralkyl, each aryl or aralkyl being optionally further substituted with alkyl, alkoxy and/or halogen.
    Type: Application
    Filed: July 25, 2013
    Publication date: November 21, 2013
    Applicant: Lonza AG
    Inventors: Dominique Michel, Rudolf Fuchs
  • Patent number: 8569545
    Abstract: The present invention relates to an improved process for the preparation of (R)-1-aminoindan (2), rasagiline (1) and pharmaceutically acceptable salts of rasagiline.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: October 29, 2013
    Assignee: Generics (UK) Limited
    Inventors: Vinayak Gore, Bindu Manojkumar, Sandeep Sonawane, Dattatrey Kokane, Sinerpal Tank
  • Patent number: 8551624
    Abstract: There is provided a compound having Formula I or Formula II: In the Formulae: Ar1 is an arylene having 6-30 carbons; Ar2 is an aryl group; Ar3 is an arylene; R1 is selected from H, D, aryl groups, alkyl groups, silyl groups, siloxane groups, fluoroalkyl groups, alkoxy groups, and fluoroalkoxy groups; R2 is selected from D, aryl groups, alkyl groups, silyl groups, siloxane groups, fluoroalkyl groups, alkoxy groups, or fluoroalkoxy groups; M is a conjugated moiety; a is an integer from 0 to 2; b is an integer from 0 to 3; n is an integer equal to or greater than 1; and x and y are mole fractions where x+y=1.0.
    Type: Grant
    Filed: December 1, 2009
    Date of Patent: October 8, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Kyung-Ho Park, Nora Sabina Radu
  • Patent number: 8546580
    Abstract: Chemical stain compounds containing a fluorophore and a reducible quenching unit are disclosed. The reducible quenching unit quenches the fluorophore while in its oxidized state. Upon reduction, the quenching properties of the quenching unit are diminished or eliminated. The chemical compounds can be used in a variety of applications, including the detection of bacterial cells, monitoring the electron transport chain function of bacterial cells, monitoring the oxidation state of non-biological systems, and assaying the effectiveness of antibacterial or antimicrobial agents.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: October 1, 2013
    Assignee: Life Technologies Corporation
    Inventors: Ching-Ying Cheung, Diane Gray, Stephen Yue
  • Publication number: 20130248847
    Abstract: There is disclosed a compound having Formula I In Formula I: Ar1 through Ar4 are the same or different and are aryl groups; L is a spiro group, an adamantyl group, bicyclic cyclohexyl, deuterated analogs thereof, or substituted derivatives thereof; R1 is the same or different at each occurrence and is D, F, alkyl, aryl, alkoxy, silyl, or a crosslinkable group, where adjacent R1 groups can be joined together to form an aromatic ring; R2 is the same or different at each occurrence and is H, D, or halogen; a is the same or different at each occurrence and is an integer from 0-4; and n is an integer greater than 0.
    Type: Application
    Filed: December 19, 2011
    Publication date: September 26, 2013
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Nora Sabina Radu, Adam Fennimore
  • Patent number: 8541475
    Abstract: The invention provides novel compounds of formulae I and II: that are monoamine oxidase-B inhibitors, which can be useful in treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance).
    Type: Grant
    Filed: December 31, 2009
    Date of Patent: September 24, 2013
    Assignee: Jenrin Discovery, Inc.
    Inventors: John Francis McElroy, Robert J. Chorvat, Parthasarathi Rajagopalan
  • Publication number: 20130225679
    Abstract: Provided are analgesic compounds, and salts thereof, of formula: (I) wherein A is: (A) Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided.
    Type: Application
    Filed: January 13, 2012
    Publication date: August 29, 2013
    Applicant: ELI LILLY AND COMPANY
    Inventors: Jean Marie Defauw, Scott Dale Holmstrom, Shuhui Chen, Yang Zhang, Wentao Wu, Xian Peng, Yujuan Ma, Lun Lu
  • Publication number: 20130211082
    Abstract: A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N-{N-{4-[N-((6S)-2-hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzoyl}-L-?-glutamyl}-D-glutamic acid (ONX-0801).
    Type: Application
    Filed: July 15, 2011
    Publication date: August 15, 2013
    Applicant: ONYX Pharmaceuticals, Inc.
    Inventors: James Alan Kerschen, Alexander James Bridges, Sean Mark Daizlel, Olivier Dapremont, Hyunjung Kim, Andrew S. Thompson, James Robert Zeller