Sulfur Attached Indirectly To The Amino Nitrogen By Nonionic Bonding Patents (Class 564/440)
  • Patent number: 9801373
    Abstract: The present invention pertains to plant additives capable of alleviating phosphate starvation symptoms in plants and promoting the growth of phosphate deprived plants. These plant additives are molecules comprising the group of formula.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: October 31, 2017
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Laurent Nussaume, Carole Arnaud, Mathilde Clement, Thierry Desnos
  • Patent number: 9168614
    Abstract: A method of generating a hole or well in an electrically insulating or semiconducting substrate, a hole or well in a substrate generated by this method, and an array of holes or wells in a substrate generated by the method.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 27, 2015
    Assignee: ASAHI GLASS CO., LTD.
    Inventors: Christian Schmidt, Leander Dittmann, Adrien Chaize, Svend Hoyer
  • Publication number: 20150141582
    Abstract: Vulcanizates with desirable properties can be obtained from compounds incorporating polymers that include hydroxyl group-containing aryl functionalities. The functionalities can be incorporated by using any or all of appropriate initiators, monomers and optional terminating compounds. Such polymers exhibit excellent interactivity with both conventional and non-conventional fillers.
    Type: Application
    Filed: October 26, 2014
    Publication date: May 21, 2015
    Inventors: Yuan-Yong Yan, Zengquan Qin, Xiao-Dong Pan, Dennis R. Brumbaugh
  • Publication number: 20150073178
    Abstract: [Problem] For example, 4-(3-benzyloxyphenylthio)-2-chloro-1-(3-nitropropyl)benzene (compound 1) is used as an intermediate for producing a 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride which has excellent immunosuppressive activity. This compound 1 is traditionally obtained only as an oil and thus handling and refining were difficult. [Solution] A crystal of the compound 1 is obtained. A method of crystallizing the same is also established. Furthermore, a simple refining method is also found which comprises stirring in suspension the crystal in a solvent. Since the compound 1 can be obtained as a crystal, it is easier to handle and long term storage is possible.
    Type: Application
    Filed: April 17, 2013
    Publication date: March 12, 2015
    Inventors: Takeshi Tsubuki, Hiroya Sato
  • Publication number: 20140348880
    Abstract: A method for treating or preventing a microbial infection in a subject in need thereof, the method comprising administering to the subject, a therapeutically effective amount of a compound of Formula Ia, a compound of Formula IIa, one or more compounds of Formula Ia or Formula IIa complexed with a metal core, or a pharmaceutically acceptable salt, prodrug or hydrate thereof.
    Type: Application
    Filed: May 23, 2014
    Publication date: November 27, 2014
    Inventors: Matthias Bierenstiel, Harshiny Muthukumar
  • Patent number: 8816128
    Abstract: Aniline derivatives represented by formula (8): The aniline derivatives can be used as insecticides and/or intermediates in production of insecticides.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: August 26, 2014
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Kei Yoshida, Takeo Wakita, Hiroyuki Katsuta, Akiyoshi Kai, Yutaka Chiba, Kiyoshi Takahashi, Hiroko Kato, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido, Junji Maki, Shinichi Banba, Atsuko Kawahara
  • Publication number: 20140235565
    Abstract: The present invention provides N-alkylthio ?-lactams and disulfide compounds (e.g., alkyl-coenzyme A asymmetric disulfides or aryl-alkyl disulfides), compositions containing such compounds, and methods of their use as anti-bacterial agents.
    Type: Application
    Filed: May 1, 2014
    Publication date: August 21, 2014
    Applicant: UNIVERSITY OF SOUTH FLORIDA
    Inventors: EDWARD TUROS, KEVIN D. REVELL
  • Publication number: 20140212381
    Abstract: Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
    Type: Application
    Filed: October 21, 2013
    Publication date: July 31, 2014
    Applicant: Scynexis, Inc.
    Inventors: Keqiang Li, Michael Robert Peel
  • Publication number: 20140213508
    Abstract: Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described.
    Type: Application
    Filed: October 21, 2013
    Publication date: July 31, 2014
    Applicant: Scynexis, Inc.
    Inventors: Keqiang Li, Michael Robert PEEL
  • Publication number: 20140186869
    Abstract: This method for inhibiting protease in a biological sample containing pancreatic juice components inhibits protease enzyme activity in the biological sample by adding at least one type of protease inhibitor having a sulfonyl fluoride group to the biological sample containing pancreatic juice components. In addition, this protease inhibitor for a biological sample containing pancreatic juice components is a compound having a sulfonyl fluoride group, has protease inhibitory activity, and is added to a biological sample containing pancreatic juice components in order to inhibit protease present in the biological sample. Moreover, this kit for preserving a biological sample containing pancreatic juice components contains at least one type of protease inhibitory having a sulfonyl fluoride group, and is used to store a biological sample containing pancreatic juice components.
    Type: Application
    Filed: March 7, 2014
    Publication date: July 3, 2014
    Applicant: OLYMPUS CORPORATION
    Inventors: Rie KATAOKA, Mari NAKATA, Nao MORIYA
  • Publication number: 20140066659
    Abstract: A bis(trifluoromethanesulfonyl)ethyl group-bearing compound represented by the following formula [1], [2] or [3]
    Type: Application
    Filed: December 8, 2011
    Publication date: March 6, 2014
    Applicant: Central Glass Company, Limited
    Inventors: Takeo Taguchi, Hikaru Yanai
  • Patent number: 8664272
    Abstract: Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: wherein R1 is selected from the group consisting of —NH2, —NH—CH2—CO2H, —NH—CH(CH3)—CO2H, and —NH—C(CH3)2—CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 30, 2006
    Date of Patent: March 4, 2014
    Assignees: Temple University—Of the Commonwealth System of Higher Education, Icahn School of Medicine at Mount Sinai
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy, James F. Holland, Lewis R. Silverman, Svetlana Zinzar
  • Publication number: 20140024679
    Abstract: The present invention provides novel phenylcycloalkylmethylamine derivatives, and methods of preparing phenylcycloalkylmethylamine derivatives. The present invention also provides methods of using phenylcycloalkylmethylamine derivatives and compositions of phenylcycloalkylmethylamine derivatives. The pharmaceutical compositions of the compounds of the present invention can be used for treating and/or preventing obesity and obesity related co-morbid indications and depression and depression related co-morbid indications.
    Type: Application
    Filed: December 31, 2012
    Publication date: January 23, 2014
    Applicant: Reviva Pharmaceuticals, Inc.
    Inventor: Reviva Pharmaceuticals, Inc.
  • Publication number: 20130281695
    Abstract: Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.
    Type: Application
    Filed: December 1, 2011
    Publication date: October 24, 2013
    Applicant: ZHEJIANG HISOAR PHARMACEUTICAL CO., LTD.
    Inventors: Xianhua Pan, Weijin Li, Qunhui Zhang, Libo Ruan, Wansheng Yu, Fei Deng, Tianhua Ma, Mingwang Huang, Minhuan He
  • Publication number: 20130203790
    Abstract: Novel sulphur-containing compounds and pharmaceutically acceptable salts thereof are disclosed, which have utility as anti-proliferative agents against mammalian cells. The invention provides a method for synthesizing the sulphur-containing compounds.
    Type: Application
    Filed: July 9, 2012
    Publication date: August 8, 2013
    Applicant: 221076 ONTARIO INC.
    Inventors: Dheeraj RAJAN, Mark Otto BAERLOCHER
  • Patent number: 8492590
    Abstract: The present invention relates to processes for the preparation of oxindoles and ortho-substituted anilines and their use as intermediates for syntheses. The invention further relates to a process for the preparation of compounds of formula (4): where a mixture of an aniline (compound of formula Q) is reacted with a thioether (compound of formula W): in the presence of a chlorinating agent and an organic solvent at a reaction temperature in the range above ?65° C.
    Type: Grant
    Filed: April 28, 2010
    Date of Patent: July 23, 2013
    Assignee: Bayer CropScience AG
    Inventors: Mark James Ford, Gunter Karig
  • Publication number: 20130066114
    Abstract: Aniline derivatives represented by formula (8): The aniline derivatives can be used as insecticides and/or intermediates in production of insecticides.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 14, 2013
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Kei YOSHIDA, Takeo WAKITA, Hiroyuki KATSUTA, Akiyoshi KAI, Yutaka CHIBA, Kiyoshi TAKAHASHI, Hiroko KATO, Nobuyuki KAWAHARA, Michikazu NOMURA, Hidenori DAIDO, Junji MAKI, Shinichi BANBA, Atsuko KAWAHARA
  • Patent number: 8334410
    Abstract: A method for producing a 3-mercaptoaniline compound, which is a known intermediate for a 3-(1H-1,2,4-triazol-1-yl)phenylsulfide derivative, useful as a pesticide, and a method for producing a compound which can be used as a starting material in producing the 3-mercaptoaniline compound are disclosed. In one embodiment the nitro group and the chlorosulfonyl group of a 3-nitrobenzenesulfonyl chloride compound represented by general formula (1): are reduced in the presence of an acid catalyst to produce a compound of general formula (2): In the above general formulas (1) and (2), R represents an alkyl group or a cyclic alkyl group, and X represents a halogen atom.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: December 18, 2012
    Assignee: Ihara Chemical Industry Co., Ltd.
    Inventor: Kentaro Kawazoe
  • Patent number: 8318981
    Abstract: There is provided a compound having an excellent controlling effect on arthropod pests represented by the formula (I-1): wherein Z represents an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; G represents a -A1-R1 group, etc.; X represents a -A2-R4 group, etc.; X represents a -A2-R4 group, etc.; X0 represents a -A3-R6 group, etc.; or X and X0 are optionally taken together to form a -A2-T0-A3- group; M1 represents a —R8 group, etc.; A1, A2 and A3 independently represent an oxygen atom, etc.; R1 and R8 independently represents an optionally substituted C1-C20 chain hydrocarbon group, etc.; R4 and R6 independently represent an optionally substituted C1-C6 chain hydrocarbon group, etc.; and T0 represents an optionally substituted C2-C6 alkanediyl group.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: November 27, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hideo Kamiyama, Shigeyuki Itoh
  • Publication number: 20120283266
    Abstract: The invention relates to a compound of Formula (I): (A?)x-(A)-(B)-(Z)-(L)-(D), wherein: (A) is heteroaryl or aryl; each (A?), if present, is independently chosen from aryl, arylalkoxy, arylalkyl, heterocyclyl, aryloxy, halo, alkoxy, haloalkyl, cycloalkyl, haloalkoxy, and cyano, wherein each (A?) is substituted with 0, 1, 2, or 3 substituents independently chosen from halo, haloalkyl, aryl, arylalkoxy, alkyl, alkoxy, cyano, sulfonyl, amido, and sulfinyl; X is 0, 1, 2, or 3; (B) is a cyclopropyl ring, wherein (A) and (Z) are covalently bonded to different carbon atoms of (B); (Z) is —NH—; (L) is chosen from —CH2CH2—, —CH2CH2CH2—, and —CH2CH2CH2CH2—; and (D) is chosen from —N(—R1)—R2, —O—R3, and —S—R3, wherein: R1 and R2 are mutually linked to form a heterocyclic ring together with the nitrogen atom that R1 and R2 are attached to, wherein said heterocyclic ring has 0, 1, 2, or 3 substituents independently chosen from —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)(C1-C6 alkyl), alkyl, halo, cyano, alkoxy, haloalkyl, and
    Type: Application
    Filed: April 19, 2010
    Publication date: November 8, 2012
    Inventors: Alberto Ortega Muñoz, Julio Castro-Palomino Laria, Matthew Colin Thor Fyfe
  • Publication number: 20120283101
    Abstract: The present invention pertains to plant additives containing a molecule selected in a family of compounds, wherein said molecule can modulate some molecular markers and physiological modifications observed in cases of phosphate deficiency. The family of compounds comprises the molecule MC2 of formula (I) as well as analogues thereof.
    Type: Application
    Filed: September 17, 2010
    Publication date: November 8, 2012
    Inventors: Mathilde Clement, Thierry Desnos, Laurent Nussaume
  • Publication number: 20120245388
    Abstract: There are provided a 4-(trichloromethylthio)aniline represented by the general formula (II): wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 each independently represents a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a perfluoroalkyl group having 1 to 3 carbon atoms, R3 represents a formyl group, an acetyl group, or a trifluoroacetyl group, and m represents an integer of 0 to 4, a method for producing the same, and a method for producing a 4-(trifluoromethylthio)aniline derivative using the 4-(trichloromethylthio)aniline. It becomes possible to produce a 4-(trifluoromethylthio)aniline with a high yield by using raw materials that can easily be obtained industrially and using general purpose production facilities.
    Type: Application
    Filed: June 8, 2012
    Publication date: September 27, 2012
    Inventors: Yoshitomo TOHYAMA, Kengo Kanematsu
  • Publication number: 20120220802
    Abstract: Aniline derivatives represented by formula (8) and formula (9): The aniline derivatives can be used as insecticides.
    Type: Application
    Filed: March 13, 2012
    Publication date: August 30, 2012
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Kei Yoshida, Takeo Wakita, Hiroyuki Katsuta, Akiyoshi Kai, Yutaka Chiba, Kiyoshi Takahashi, Hiroko Kato, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido, Junji Maki, Shinichi Banba, Atsuko Kawahara
  • Publication number: 20120142915
    Abstract: This disclosure concerns a protected cyclopropylboronic acid comprising a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is an N-methyliminodiacetic acid (MIDA) group or MIDA-based group.
    Type: Application
    Filed: December 1, 2011
    Publication date: June 7, 2012
    Inventors: Matthew Duncton, Rajinder Singh
  • Patent number: 8188002
    Abstract: A description is given of 3-amino-2-nitro-substituted benzoyl derivatives of the formula (I) as herbicides. In this formula (I), X, R1, R2, R3, R4, R5, R6, R7 and R8 are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: May 29, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Dieter Feucht
  • Patent number: 8188315
    Abstract: Provided are an organic light emitting device including: a substrate; a first electrode; a second electrode; and an organic layer interposed between the first electrode and the second electrode and including an emission layer, wherein one of the first electrode and the second electrode is a reflective electrode and the other is a semitransparent or transparent electrode, and wherein the organic layer includes a layer having at least one of the compounds having at least one carbazole group, and a flat panel display device including the organic light emitting device. The organic light emitting device has low driving voltage, excellent current density, high brightness, excellent color purity, high efficiency, and long lifetime.
    Type: Grant
    Filed: May 29, 2007
    Date of Patent: May 29, 2012
    Assignee: Samsung Mobile Display Co., Ltd.
    Inventors: Seok-Hwan Hwang, Young-Kook Kim, Yoon-Hyun Kwak, Jong-Hyuk Lee, Kwan-Hee Lee, Min-Seung Chun
  • Publication number: 20110245284
    Abstract: Alkoxy- and alkylthio-substituted anilinopyrimidines of the formula (I) in which R1 to R14 and E1, E2, E3, X and Y have the meanings given in the description, and agrochemically active salts thereof, their use, and methods and compositions for controlling phytopathogenic harmful fungi in and/or on plants or in and/or on seeds of plants, processes for preparing such compositions and treated seeds and also their use for controlling phytopathogenic hal inful fungi in agriculture, horticulture and forestry, in the protection of materials and in the domestic and hygiene field. The present invention furthermore relates to a process for the preparation of alkoxy- and alkylthio-substituted anilinopyrimidines of the formula (I).
    Type: Application
    Filed: August 21, 2009
    Publication date: October 6, 2011
    Applicant: Bayer CropScience AG
    Inventors: Jörg Nico Greul, Hendrik Helmke, Stefan Hillebrand, Amos Mattes, Pierre Wasnaire, Carl Friedrich Nising, Ulrike Wachendorff-Neumann, Peter Dahmen, Arnd Voerste, Ruth Meissner, Chirstoph Andreas Braun, Martin Kaubmann, Hiroyuki Hadano, Ulrich Heinemann
  • Patent number: 8003702
    Abstract: This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3? kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: August 23, 2011
    Assignee: Neurim Pharmaceuticals (1991) Ltd.
    Inventors: Tal Peleg-Shulman, Moshe Laudon, Dorah Daily
  • Publication number: 20110195979
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
    Type: Application
    Filed: February 7, 2011
    Publication date: August 11, 2011
    Inventors: Li Chen, Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Lisha Wang, Jim Zhen Wu, Wengang Yang
  • Publication number: 20110098179
    Abstract: A description is given of 3-amino-2-nitro-substituted benzoyl derivatives of the formula (I) as herbicides. In this formula (I), X, R1, R2, R3, R4, R5, R6, R7 and R8 are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Application
    Filed: September 22, 2010
    Publication date: April 28, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Andreas ALMSICK, Jan Dittgen, Christopher Hugh Rosinger, Isolde HÄUSER-HAHN, Dieter Feucht
  • Patent number: 7932416
    Abstract: Pentafluorosulfanyl-benzenes according to Formula (I): a process for their preparation and their use as valuable synthetic intermediates for preparing, for example, medicaments, diagnostic aids, liquid crystals, polymers, pesticides, herbicides, fungicides, nematicides, parasiticides, insecticides, acaricides and arthropodicides.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: April 26, 2011
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Heinz-Werner Kleemann, Remo Weck
  • Publication number: 20110071142
    Abstract: The present invention relates to methods of identifying small molecule candidate agents capable of modulating transcription factor function such that the function/expression of a target transcription factor and/or proteins downstream of this target protein comprises the screening of small molecule libraries using in silico high throughput docking for candidate small molecules/agents that are selectively identified for their ability to target and disrupt the transcription factor-DNA interface through unique transcription factor and/or DNA descriptors that are defined within a pharmacophore, and then testing/evaluating the candidate agents identified above through one or more in vitro assays for their ability to modulate transcription factor function including expression of this target protein and/or proteins that are downstream of the target transcription factor. The present invention also relates to various compounds described herein (e.g.
    Type: Application
    Filed: March 19, 2010
    Publication date: March 24, 2011
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Peter Oettgen, Alan C. Rigby, Towia Libermann
  • Publication number: 20110053778
    Abstract: 2-(3-Aminobenzoyl)-3-cyclopropyl-3-oxopropanenitriles of the formula (I) are described as herbicides. In this formula (I), X and Y are organic radicals such as alkyl and other radicals such as halogen, nitro and cyano.
    Type: Application
    Filed: July 27, 2010
    Publication date: March 3, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut AHRENS, Ines Heinemann, Andreas Van Almsick, Ralf Braun, Jan Dittgen, Dieter Feucht, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Stefan Lehr
  • Publication number: 20110034562
    Abstract: The invention provides a selective Sigma 1 or Dopamine D3 receptor agonist or a 5HT2c receptor ligand for use in the treatment of symptoms of anxiety and/or depression associated with an affective disorder and/or symptoms associated with cognitive impairment disorder. Particularly useful are diphenhydramine derivatives of Formula (I) and particularly (2-[(4-butylsulfanylphenyl)-phenyl-methyl]sulfanyl-N,N-dimethyl-ethanamin) (Captodiamine).
    Type: Application
    Filed: April 20, 2009
    Publication date: February 10, 2011
    Applicant: University College Dublin, National University of Ireland, Dublin
    Inventor: CIARAN REGAN
  • Publication number: 20100331578
    Abstract: There are provided a 4-(trichloromethylthio)aniline represented by the general formula (II): wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 each independently represents a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a perfluoroalkyl group having 1 to 3 carbon atoms, R3 represents a formyl group, an acetyl group, or a trifluoroacetyl group, and m represents an integer of 0 to 4, a method for producing the same, and a method for producing a 4-(trifluoromethylthio)aniline derivative using the 4-(trichloromethylthio)aniline. It becomes possible to produce a 4-(trifluoromethylthio)aniline with a high yield by using raw materials that can easily be obtained industrially and using general purpose production facilities.
    Type: Application
    Filed: July 1, 2008
    Publication date: December 30, 2010
    Inventors: Yoshitomo Tohyama, Kengo Kanematsu
  • Publication number: 20100249462
    Abstract: A method for producing a 3-mercaptoaniline compound, which is a known intermediate for a 3-(1H-1,2,4-triazol-1-yl)phenylsulfide derivative, useful as a pesticide, and a method for producing a compound which can be used as a starting material in producing the 3-mercaptoaniline compound are disclosed. In one embodiment the nitro group and the chlorosulfonyl group of a 3-nitrobenzenesulfonyl chloride compound represented by general formula (1): are reduced in the presence of an acid catalyst to produce a compound of general formula (2): In the above general formulas (1) and (2), R represents an alkyl group or a cyclic alkyl group, and X represents a halogen atom.
    Type: Application
    Filed: November 28, 2008
    Publication date: September 30, 2010
    Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.
    Inventor: Kentaro Kawazoe
  • Patent number: 7799951
    Abstract: The instant invention discloses a process for preventing contact discoloration of substrates coming into contact with elastomers and stabilizing elastomers to prevent oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation, which comprises incorporating into the elastomers, or applying to these, at least a compound of the formula (I) wherein R1 is C1-C12alkyl, R2 is C1-C12alkyl, or R1 and R2 together with the carbon atom to which they are attached form an unsubstituted or with C1-C4alkyl substituted C5-C12cycloalkyl ring; R3 is hydrogen or —CH2—S(O)m—R5, R4 and R5 independently of each other are unsubstituted or with cyano substituted C5-C18-alkyl; C7-C9phenylalkyl, unsubstituted or with halogen, hydroxyl, cyano or C1-C4alkyl substituted phenyl or naphthyl; benzothiazolyl or —R6—CO2—R7, R6 is C1-C18alkylene, R7 is C1-C18alkyl, and m is 0, 1 or 2.
    Type: Grant
    Filed: October 2, 2006
    Date of Patent: September 21, 2010
    Assignee: Ciba Corporation
    Inventors: Michèle Gerster, Hans-Rudolf Meier, Gerrit Knobloch, Pierre Rota-Graziosi
  • Patent number: 7786177
    Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH?C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: August 31, 2010
    Assignee: UCB Pharma S.A.
    Inventors: Stephen Brand, Stuart Bailey, Julien A. Brown, James A. Johnson, John R. Porter, John C. Head
  • Patent number: 7714089
    Abstract: Rubbery polymers can be formed having the general formula: R1R2N—(CH2)n—X—CH2—CHR3R4 wherein R1 and R2 are independently selected from a group consisting of alkyls, cycloalkyls, alkenyls, cycloalkenyls, aryls, phenyls, heterocycles, acyls, and silanes, or R1 in combination with R2 forms a heterocyclic ring; n is an integer from 1 to 20; X is selected from a group consisting of sulfur, a phosphorus moiety, and a silicon moiety; R3 and R4 are one of hydrogen, alkyls, alkenyls, and at least one of which includes reactive unsaturation such as an alkenyl group. Moreover, this invention discloses a process of making functionalized rubbery polymers from the functionalized monomers.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: May 11, 2010
    Assignee: The Goodyear Tire & Rubber Company
    Inventors: Adel Farhan Halasa, Wen-Liang Hsu, Leh-Yeh Hsu, legal representative, Shingo Futamura, Joe Zhou, Chad Aaron Jasiunas
  • Publication number: 20100048663
    Abstract: This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3? kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
    Type: Application
    Filed: November 3, 2009
    Publication date: February 25, 2010
    Applicant: NEURIM PHARMACEUTICALS (1991) LTD.
    Inventors: Tal Peleg-Shulman, Moshe Laudon, Dorah Daily
  • Patent number: 7659429
    Abstract: A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, for example, for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: October 9, 2008
    Date of Patent: February 9, 2010
    Assignee: sanofi-aventis Deutschland GmbH
    Inventors: Gerrit Schubert, Heinz-Werner Kleemann
  • Publication number: 20090264660
    Abstract: An alkyl aryl sulfide of Chemical Formula (III) is prepared by substituting an aryl halogen compound of Chemical Formula (I) with an alkyl lithium organometallic reagent. The sulfide is subsequently reacted with a compound of Chemical Formula (II). Alternatively an aryl halogen compound of Chemical Formula (I) is reacted with Grignard reagent to protect the hydrogen-donating substituent, and then reacted with an alkyl lithium organometallic reagent, and subsequently with sulfur and a compound of Chemical Formula (II). An alkyl aryl sulfide of Chemical Formula (III) is prepared via a one-step reaction without separation or purification of an intermediate compound from various aryl halogen compounds.
    Type: Application
    Filed: October 21, 2005
    Publication date: October 22, 2009
    Inventors: Heonjoong Kang, Jungyeob Ham, Jaeyoung Ko
  • Publication number: 20090191193
    Abstract: Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula I: wherein Ar1, Ar2, D, G, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, synthetic processes, and intermediates useful in such processes are provided.
    Type: Application
    Filed: August 1, 2007
    Publication date: July 30, 2009
    Applicant: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: E. Premkumar Reddy, M.V. Ramana Reddy
  • Publication number: 20090156769
    Abstract: Rubbery polymers can be formed having the general formula: R1R2N—(CH2)n—X—CH2—CHR3R4 wherein R1 and R2 are independently selected from a group consisting of alkyls, cycloalkyls, alkenyls, cycloalkenyls, aryls, phenyls, heterocycles, acyls, and silanes, or R1 in combination with R2 forms a heterocyclic ring; n is an integer from 1 to 20; X is selected from a group consisting of sulfur, a phosphorus moiety, and a silicon moiety; R3 and R4 are one of hydrogen, alkyls, alkenyls, and at least one of which includes reactive unsaturation such as an alkenyl group. Moreover, this invention discloses a process of making functionalized rubbery polymers from the functionalized monomers.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 18, 2009
    Inventors: Adel Farhan Halasa, Wen-Liang Hsu, Leh-Yeh Hsu, Shingo Futamura, Joe Zhou, Chad Aaron Jasiunas
  • Publication number: 20090076282
    Abstract: To provide novel 3-triazolylphenyl sulfide derivatives having excellent soil treatment activity as insecticides, miticides or nematicides for agricultural and horticultural plants. 3-Triazolylphenyl sulfide derivatives represented by the formula [1]: wherein R is a cyclopropylmethyl group or a trifluoroethyl group, B2 is a hydrogen atom, a halogen atom or a methyl group, B4 is a halogen atom, a cyano group, a nitro group or a C1-C6 alkyl group, and each of A1 and A3 is a hydrogen atom, a halogen atom, a C1-C6 alkyl group which may be substituted or an amino group which may be substituted.
    Type: Application
    Filed: October 20, 2005
    Publication date: March 19, 2009
    Applicants: KUMIAI CHEMICAL INDUSTRY CO., LTD, IHARA CHEMICAL INDUSTRY CO., LTD
    Inventors: Keiji Toriyabe, Mikio Yamaguchi, Yoshihiro Ito, Shiori Kinpara, Hiroyuki Yano, Satoru Takahashi, Norihisa Yonekura, Ryuji Hamaguchi
  • Publication number: 20090036704
    Abstract: A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NHE1 inhibitors and can be employed, for example, for the treatment of cardiovascular disorders.
    Type: Application
    Filed: October 9, 2008
    Publication date: February 5, 2009
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Gerrit Schubert, Heinz-Werner Kleemann
  • Patent number: 7449594
    Abstract: A process for preparing 4-pentafluorosulfanylbenzoylguanidines of formula I wherein R1 to R4 have the meanings indicated in the specification. The compounds of formula I are NEH1 inhibitors and can be employed, for example, for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: November 11, 2008
    Assignee: Sanofi-aventis Deutschland GmbH
    Inventors: Gerrit Schubert, Heinz-Werner Kleemann
  • Patent number: 7446226
    Abstract: The invention relates to new compounds, namely capsaicin derivates, a new method for their production, and their use as micro-organism-repellent agents in paints and coatings, in particular for marine installations and ships, but also for land-based structures.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: November 4, 2008
    Assignee: aXimed AS
    Inventors: Torsten Helsing, Einar Bakstad
  • Publication number: 20080262238
    Abstract: A dendron or dendrimer, which has, as a recurring unit of each branch, a structure of formula (I): wherein TC designates a linkage to a former generation in the direction to a focal point of the dendron or a core of the dendrimer; TT designates a linkage to a next generation in the direction to a terminal; X is a divalent group comprised of at least one heteroatom; L1 and L2 each are a divalent linking group; R is a hydrogen atom or a substituent; and a method of producing a dendron or a dendrimer; and a method of producing a thioacetal compound.
    Type: Application
    Filed: March 28, 2005
    Publication date: October 23, 2008
    Inventor: Koki Nakamura
  • Publication number: 20080261952
    Abstract: A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment.
    Type: Application
    Filed: August 16, 2005
    Publication date: October 23, 2008
    Inventors: Jason Bloxham, Matthew Colin Thor Fyfe, James Horswill, Revathy Perpetua Jeevaratnam, John Keily, Martin James Procter, Karen Lesley Schofield, Salam Shaaban, Andrew Simon Swain, Phillppe Wong-Kai-In