Nitro Or Nitroso, Bonded Directly To Carbon, Containing Patents (Class 564/441)
  • Patent number: 10143646
    Abstract: The present invention relates to an agent for oxidatively coloring or blonding hair that is gentle on the hair, and to a gentle method for oxidatively coloring or blonding hair, in which keratin fibers are protected from oxidative influences.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: December 4, 2018
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thomas Hippe, Astrid Kleen-Fehres, Hartmut Manneck
  • Patent number: 9980891
    Abstract: An agent for oxidative hair coloring or bleaching, which is gentle on the hair, and a gentle method for oxidative hair coloring or bleaching, in which keratin fibers are protected against oxidative effects.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: May 29, 2018
    Assignee: Henkel AG & Co. KGaA
    Inventors: Hartmut Manneck, Thomas Hippe, Astrid Kleen-Fehres
  • Patent number: 9688946
    Abstract: A cleaning composition comprises at least one surfactant and at least one colorant. The cleaning composition can have a pH of about 3 or less. The colorant exhibits one of several specified structures at a pH of about 7. A method for cleaning a surface utilizes the cleaning composition.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: June 27, 2017
    Assignee: Milliken & Company
    Inventors: Yogesh Saraf, Eduardo Torres, Sanjeev K. Dey, Paul D. Halphen
  • Patent number: 9417226
    Abstract: A method for the detection of explosives using a single sample. The explosives include nitro aliphatic and nitro aromatic-based explosives. The method includes steps which require different pHs to discriminate between these types of explosives and at least in the detection step of the nitro aliphatic explosive requires the presence of a nitro aromatic compound. A kit for detecting explosives which includes a medium for collecting a sample, a base optionally impregnated on the medium; and a nitro aromatic solution for detecting a nitro aliphatic explosive by contacting the solution with the sample on the medium. A reagent including a nitro aromatic compound, having one or more additional electron withdrawing groups, in the presence of a basic compound usable for detecting nitro aliphatic explosives.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: August 16, 2016
    Assignee: MISTRAL DETECTION LTD
    Inventor: Shai Amisar
  • Patent number: 9034463
    Abstract: An object of the present invention is to produce a non-conventional high-quality BNA single crystal. Another object of the present invention is to provide a process for producing the above-described high-quality BNA single crystal. Specifically, the present invention provides a BNA crystal characterized by having a half-value width of diffraction peak X-ray intensity of 100 seconds or less in a rocking curve measurement by X-ray diffraction method.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: May 19, 2015
    Assignee: RIKEN
    Inventors: Mikiko Saito, Takashi Notake, Hiroaki Minamide, Hiromasa Ito
  • Publication number: 20150099720
    Abstract: Provided herein are compounds having a structure selected from among Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and Formula (VI) that are androgen receptor modulators and/or androgen receptor binding agents. Also disclosed are methods of making and using such compounds, including, but not limited to, using such compounds for treating various conditions.
    Type: Application
    Filed: October 20, 2014
    Publication date: April 9, 2015
    Inventors: Lin Zhi, Robert I. Higuchi, E. Adam Kallel, Cornelis Arjan Van Oeveren, Jyun-Hung Chen, Daniel A. Ruppar, Bijan Pedram, Thomas Lot Stevens Lau, Todd A. Miller
  • Patent number: 8962890
    Abstract: Multifunctional amine crosslinkers that may be used to create crosslinked polyimide, polyamide, and poly(amide-imide) polymers and films having shape memory properties at elevated temperatures and methods of making the same.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: February 24, 2015
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: Loon-Seng Tan, David Huabin Wang
  • Publication number: 20140275603
    Abstract: A process for making a 2-nitro-1-ethanol derivative of formula III: wherein R3 is as described herein is provided. Novel 2-nitro-1-ethanol derivatives provided.
    Type: Application
    Filed: March 26, 2012
    Publication date: September 18, 2014
    Applicant: ANGUS Chemical Company
    Inventors: Raymond J. Swedo, George David Green, Charles E. Coburn
  • Publication number: 20140170457
    Abstract: A secondary cell, in particular a lithium-sulfur cell, that encompasses a cathode having an electrochemically active cathode active material, an anode having an electrochemically active anode active material, and a liquid electrolyte, the cathode active material and/or anode active material changing, in the context of the charging or discharging operation, from a solid phase form into a liquid phase form that is soluble in the electrolyte. To increase the charging/discharging rate and cycle stability and to decrease overvoltages, the secondary cell encompasses at least one redox additive that is soluble in reduced form and oxidized form in the electrolyte and that is suitable for reacting with the phase-changing electrode active material in a redox reaction in such a way that the electrode active material is convertible from the solid phase form into the liquid phase form.
    Type: Application
    Filed: November 28, 2011
    Publication date: June 19, 2014
    Inventors: Marcus Wegner, Jens Grimminger, Martin Tenzer, Jake Christensen
  • Publication number: 20140163256
    Abstract: A method for producing a nitrobenzene compound represented by general formula (2), wherein R1 and R5 are the same or different, and each is a halogen atom or another functional group, and R2, R3, and R4 are the same or different, and each is a hydrogen atom or another functional group, comprises oxidizing an aniline compound represented by general formula (1), wherein R1, R2, R3, R4, and R5 are the same as described above, with hydrogen peroxide in the presence of a tungsten compound under an acidic condition, followed by oxidation with hydrogen peroxide under a neutral to alkaline condition.
    Type: Application
    Filed: July 4, 2012
    Publication date: June 12, 2014
    Applicant: IHARA CHEMICAL INDUSTRY CO., LTD.
    Inventors: Shinki Tani, Nami Yadomatsu, Akiko Ikumi, Yuuki Hirano, Takuya Ido
  • Publication number: 20140080832
    Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
    Type: Application
    Filed: November 13, 2013
    Publication date: March 20, 2014
    Applicant: MANNKIND CORPORATION
    Inventors: John Bruce PATTERSON, David Gregory LONERGAN, Gary A. FLYNN, Qingping ZENG, Peter V. PALLAI
  • Publication number: 20130316985
    Abstract: A pharmaceutical composition including at least one compound of the Formulas (I), (II), or (III), or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, as defined herein. Also disclosed is a method of treatment of diseases which are pathophysiologically related to GPR35, the GPR35-hERG signaling complex, or both, as defined herein.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 28, 2013
    Applicant: Corning Incorporated
    Inventors: Huayun Deng, Ye Fang
  • Patent number: 8569356
    Abstract: The invention relates to cyclin dependent kinase inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: October 29, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: David A. Ostrov, Brian K. Law, Patrick Corsino
  • Publication number: 20130237725
    Abstract: Asymmetrical 2,5-disubstituted-1,4-diaminobenzenes are provided, along with a process for forming both symmetrical and asymmetrical 2,5-disubstituted-1,4-diaminobenzenes.
    Type: Application
    Filed: March 9, 2012
    Publication date: September 12, 2013
    Inventors: Zhang-Lin Zhou, Si-Ty Lam, Lihua Zhao
  • Patent number: 8476336
    Abstract: The invention relates to an ophthalmologic composition including a dye of the general formula I in which R1=substituted or unsubstituted hydrocarbon radical, R2=substituted or unsubstituted hydrocarbon radical with at least one polymerizable double bond, R3?H or substituted or unsubstituted hydrocarbon radical, R4?H, electron-withdrawing substituent or substituted or unsubstituted hydrocarbon radical and X?O, S, NH or NR5, wherein R5 is a substituted and/or unsubstituted hydrocarbon radical. Moreover, the invention relates to another ophthalmologic composition and an ophthalmologic lens.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: July 2, 2013
    Assignee: Acri.Tec GmbH
    Inventor: Juergen Nachbaur
  • Publication number: 20130108853
    Abstract: An object of the present invention is to produce a non-conventional high-quality BNA single crystal. Another object of the present invention is to provide a process for producing the above-described high-quality BNA single crystal. Specifically, the present invention provides a BNA crystal characterized by having a half-value width of diffraction peak X-ray intensity of 100 seconds or less in a rocking curve measurement by X-ray diffraction method.
    Type: Application
    Filed: June 10, 2011
    Publication date: May 2, 2013
    Applicant: RIKEN
    Inventors: Mikiko Saito, Takashi Notake, Hiroaki Minamide, Hiromasa Ito
  • Patent number: 8420862
    Abstract: Highly pure 2,3,5,6-tetraaminotoluene species are produced by chemically reducing undesirable oxidation byproducts. The 2,3,5,6-tetraaminotoluene species are then used in the manufacture of superior high-performance polybenzimidazole polymers.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: April 16, 2013
    Assignee: E I du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Publication number: 20130045949
    Abstract: Described herein are compounds that may be selectively activated to produce active anti-cancer agents in tumor cells. Also disclosed are pharmaceutical compositions comprising the compounds, and methods of treating cancer using the compounds.
    Type: Application
    Filed: July 1, 2012
    Publication date: February 21, 2013
    Applicant: UWM RESEARCH FOUNDATION, INC.
    Inventors: Xiaohua Peng, Yunyan Kuang, Sheng Cao, Wenbing Chen, Yibin Wang
  • Publication number: 20120296122
    Abstract: Disclosed are fluoroether-functionalized aminoaromatic compounds and derivatives thereof. The compounds disclosed have utility as functionalized monomers and co-monomers in polyamides, polyoxadiazoles. Incorporation of the monomers into polymers can provide improved soil resistance to articles produced from the polymers.
    Type: Application
    Filed: May 17, 2011
    Publication date: November 22, 2012
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Neville Everton Drysdale, Fredrik Nederberg
  • Publication number: 20120296123
    Abstract: Disclosed are functionalized fluoroether-functionalized nitroaromatic compounds and derivatives thereof. The compounds disclosed have utility as precursors of functionalized monomers and co-monomers in polyamides, polyoxadiazoles and the like. Incorporation of the monomers into polymers can provide improved soil resistance to articles produced from the polymers.
    Type: Application
    Filed: May 17, 2011
    Publication date: November 22, 2012
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Neville Everton Drysdale, Fredrik Nederberg
  • Patent number: 8309602
    Abstract: The present invention relates to multi-substituted m-diarylanilines or pharmaceutically acceptable salts thereof, wherein X, R1-R7 are as defined in the claims, their preparation process, pharmaceutical compositions comprising them and their use for the manufacture of a medicament for anti-HIV.
    Type: Grant
    Filed: October 7, 2008
    Date of Patent: November 13, 2012
    Assignees: Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences P.L.A. China
    Inventors: Lan Xie, Bingjie Qin, Kuo-Hsiung Lee, Shibo Jiang, Hong Lu
  • Patent number: 8309767
    Abstract: The invention relates to 2-aminobenzoyl-alkylamines, -alkylamides and -alkylthioamides, and their application for treatment or prevention of various physiological conditions.
    Type: Grant
    Filed: June 24, 2004
    Date of Patent: November 13, 2012
    Assignee: Neurim Pharmaceuticals (1991) Ltd.
    Inventors: Nava Zisapel, Moshe Laudon, Dvorah Daily
  • Publication number: 20120283101
    Abstract: The present invention pertains to plant additives containing a molecule selected in a family of compounds, wherein said molecule can modulate some molecular markers and physiological modifications observed in cases of phosphate deficiency. The family of compounds comprises the molecule MC2 of formula (I) as well as analogues thereof.
    Type: Application
    Filed: September 17, 2010
    Publication date: November 8, 2012
    Inventors: Mathilde Clement, Thierry Desnos, Laurent Nussaume
  • Publication number: 20120264605
    Abstract: Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA
    Inventors: Robin D. Rogers, Daniel T. Daly, Richard P. Swatloski, Whitney L. Hough-Troutman, James Hilliard Davis, JR., Marcin Smiglak, Juliusz Pernak, Scott K. Spear
  • Patent number: 8197722
    Abstract: Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: June 12, 2012
    Assignee: The California Institute of Technology
    Inventors: Seth Marder, Joseph Perry
  • Publication number: 20120142915
    Abstract: This disclosure concerns a protected cyclopropylboronic acid comprising a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is an N-methyliminodiacetic acid (MIDA) group or MIDA-based group.
    Type: Application
    Filed: December 1, 2011
    Publication date: June 7, 2012
    Inventors: Matthew Duncton, Rajinder Singh
  • Patent number: 8188002
    Abstract: A description is given of 3-amino-2-nitro-substituted benzoyl derivatives of the formula (I) as herbicides. In this formula (I), X, R1, R2, R3, R4, R5, R6, R7 and R8 are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: May 29, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Dieter Feucht
  • Patent number: 8188316
    Abstract: Processes are provided for preparing complexes of 2,3,5,6-tetraaminotoluene with an aromatic diacid where the aromatic diacid is insoluble in water under ambient conditions. An integrated process design starting with nitration of 2,6-dihalotoluene eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: May 29, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8188317
    Abstract: An integrated process is provided for preparing complexes of 2,3,5,6-tetraminotoluene with an aromatic diacid starting with nitration of 2,6-dihalotoluene. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: May 29, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8163961
    Abstract: Complexes of 2,3,5,6-tetraaminotoluene with an aromatic diacid are prepared by reaction with a divalent salt of the aromatic diacid while maintaining the pH of the reaction solution between 3 and 10. The resulting complexes are suitable for making high molecular weight polybenzimidazole polymers for high-performance fibers.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: April 24, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Rajiv Dhawan, Joachim C. Ritter
  • Patent number: 8158830
    Abstract: An integrated process is provided for preparing 1,2,4,5-tetraminobenzene and salts thereof, starting in certain embodiments with nitration of 1,3-dihalobenzene. The process design eliminates costly intermediate drying and recrystallization steps. Handling of solid materials with possible skin sensitizing properties and toxicity is avoided, thereby eliminating human and environmental exposure.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: April 17, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Joachim C. Ritter, Ekaterini Korovessi, Rajiv Dhawan
  • Patent number: 8071812
    Abstract: A process is provided for the preparation of 1,3-diamino-4,6-dinitrobenzene by amination of 1,3-dihalo-4,6-dinitrobenzene. The presence of water advantageously results in a highly pure product, free or essentially free of glycol ether impurities.
    Type: Grant
    Filed: December 16, 2008
    Date of Patent: December 6, 2011
    Assignee: E.I du Pont de Nemours & Company
    Inventors: Joachim C. Ritter, Annalisa Hargis
  • Publication number: 20110294976
    Abstract: A compound comprises a polymeric chain with a repeat unit repeated more than 5 times. The repeat unit comprises conjugated first and second cyclic groups and a plurality of side groups each bonded to one of the cyclic groups. A side group bonded to the first cyclic group is an electron donor and a side group bonded to the second cyclic group is an electron acceptor, such that the compound is switchable between first and second electrical conductive states by application of an electric field to the compound. At least one of the side groups is selected so that the compound is soluble in an organic solvent. The compound may be used in films, memory cells, or electronic devices. A layer of the compound may be formed on a surface by dissolving the compound in an organic solvent, applying the solution to the surface, and then removing the solvent.
    Type: Application
    Filed: February 4, 2010
    Publication date: December 1, 2011
    Applicant: National University of Singpore
    Inventors: Qi-Dan Ling, Chuxiang Zhu, Daniel Siu-Hung Chan, En-Tang Kang, Koon-Gee Neoh
  • Publication number: 20110288296
    Abstract: The application relates to a reagent of the general formula R1R2N—ZnY LiY??(I) wherein R1, R2 are, independently, selected from H, substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or silyl derivatives thereof; and R1 and R2 together can be part of a cyclic or polymeric structure; and wherein at least one of R1 and R2 is other than H; Y is selected from the group consisting of F; Cl; Br; I; CN; SCN; NCO; Halon, wherein n=3 or 4 and Hal is selected from Cl, Br and I; NO3; BF4; PF6; H; a carboxylate of the general formula RXCO2; an alcoholate of the general formula ORX; a thiolate of the general formula SRX; RXP(O)O2; or SCORX; or SCSRX; OnSRx; wherein n=2 or 3; or NOn, wherein n=2 or 3; and a derivative thereof; wherein Rx is a substituted or unsubstituted aryl or heteroaryl containing one or more heteroatoms, linear, branched or cyclic, substituted or unsubstituted alkyl, alkenyl, alkynyl, or
    Type: Application
    Filed: February 11, 2010
    Publication date: November 24, 2011
    Inventors: Paul Knochel, Marc Mosrin
  • Publication number: 20110105800
    Abstract: Embodiments of methods for preparing 3-aminopicric acid from picric acid is described. In one embodiment, the method comprises combining lithium hydroxide, picric acid, and a first solvent to form a first solution, combining lithium hydroxide, hydroxylamine hydrochloride, and a second solvent to form a second solution, combining the first solution with the second solution to form a mixture, and cooling the mixture.
    Type: Application
    Filed: November 3, 2010
    Publication date: May 5, 2011
    Inventors: John W. FRONABARGER, Michael D. WILLIAMS
  • Publication number: 20110098179
    Abstract: A description is given of 3-amino-2-nitro-substituted benzoyl derivatives of the formula (I) as herbicides. In this formula (I), X, R1, R2, R3, R4, R5, R6, R7 and R8 are radicals such as hydrogen, organic radicals such as alkyl, and other radicals such as halogen.
    Type: Application
    Filed: September 22, 2010
    Publication date: April 28, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Andreas ALMSICK, Jan Dittgen, Christopher Hugh Rosinger, Isolde HÄUSER-HAHN, Dieter Feucht
  • Publication number: 20110053778
    Abstract: 2-(3-Aminobenzoyl)-3-cyclopropyl-3-oxopropanenitriles of the formula (I) are described as herbicides. In this formula (I), X and Y are organic radicals such as alkyl and other radicals such as halogen, nitro and cyano.
    Type: Application
    Filed: July 27, 2010
    Publication date: March 3, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut AHRENS, Ines Heinemann, Andreas Van Almsick, Ralf Braun, Jan Dittgen, Dieter Feucht, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Stefan Lehr
  • Publication number: 20100319243
    Abstract: The present disclosure relates to a gasoline combustion improver comprising an organic nitro compound with C—NO2 bond dissociation energy of about 60 to about 80 Kcal/mol of compound, wherein the organic nitro compound is selected from the group consisting of nitro-aromatics, heteroatom aromatic ring compounds, heteroatom nonaromatic ring compounds, and nitrated furfuryls, and wherein the organic nitro compound is not nitrotoluene or dinitrotoluene.
    Type: Application
    Filed: June 22, 2009
    Publication date: December 23, 2010
    Applicant: Afton Chemical Corporation
    Inventors: Allen A. ARADI, Joseph W. Roos
  • Publication number: 20100292324
    Abstract: The present invention relates to multi-substituted m-diarylanilines or pharmaceutically acceptable salts thereof, wherein X, R1-R7 are as defined in the claims, their preparation process, pharmaceutical compositions comprising them and their use for the manufacture of a medicament for anti-HIV.
    Type: Application
    Filed: October 7, 2008
    Publication date: November 18, 2010
    Inventors: Lan Xie, Bingjie Qin, Kou-Hsiung Lee, Shibo Jiang, Hong Lu
  • Publication number: 20100256418
    Abstract: A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C-6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R.sup.
    Type: Application
    Filed: March 17, 2010
    Publication date: October 7, 2010
    Inventors: Sebastian Peer SMIDT, Jochen Dietz, Michael Keil, Thomas Grote
  • Patent number: 7786177
    Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH?C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: August 31, 2010
    Assignee: UCB Pharma S.A.
    Inventors: Stephen Brand, Stuart Bailey, Julien A. Brown, James A. Johnson, John R. Porter, John C. Head
  • Publication number: 20100210876
    Abstract: This invention provides a microreactor comprising a microchamber provided with a raw material introduction port and a product discharge port; wherein solid catalysts are aligned in a line in the longitudinal direction of the microchamber to fill the microchamber.
    Type: Application
    Filed: October 10, 2008
    Publication date: August 19, 2010
    Applicants: Nippon Soda Co., Ltd., Osaka Prefecture University Public Corporation
    Inventors: Ilhyong Ryu, Masaaki Sato, Takahiro Sagae, Kenichi Hayashi
  • Publication number: 20100174104
    Abstract: Asymmetric cyclopropanation of olefins with diazosulfones.
    Type: Application
    Filed: March 16, 2009
    Publication date: July 8, 2010
    Inventors: X. Peter Zhang, Shifa Zhu
  • Publication number: 20100160482
    Abstract: The invention relates to an ophthalmologic composition including a dye of the general formula I in which R1=substituted or unsubstituted hydrocarbon radical, R2=substituted or unsubstituted hydrocarbon radical with at least one polymerizable double bond, R3?H or substituted or unsubstituted hydrocarbon radical, R4?H, electron-withdrawing substituent or substituted or unsubstituted hydrocarbon radical and X?O, S, NH or NR5, wherein R5 is a substituted and/or unsubstituted hydrocarbon radical. Moreover, the invention relates to another ophthalmologic composition and an ophthalmologic lens.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 24, 2010
    Inventor: Juergen Nachbaur
  • Publication number: 20090266995
    Abstract: The present invention provides methods and compositions for modulating x-ray attenuation, where the x-ray attenuation compound can comprise a molecule having at least two conformational states, a first k-edge atom attached to the molecule at a first position, and a second k-edge atom attached to the molecule at a second position, where the molecule changes from a first conformational state to a second conformational state in response to an external stimulus. Additionally, a first interatom distance between the first k-edge atom and the second k-edge atom in the first conformational state can be within a first harmonic error of 0 to about 0.2, and a second interatom distance between the first k-edge atom and the second k-edge atom in the second conformational state can be within a second harmonic error of about 0.8 to 1.0.
    Type: Application
    Filed: April 14, 2009
    Publication date: October 29, 2009
    Inventors: Steven Poelzing, Rengasayee Veeraraghavan, Adam Smoot
  • Publication number: 20080317806
    Abstract: A compound of Formula (A), wherein R1 is C1-C5 alkyl, C3-C6 branched alkyl, C4-C7 cycloalkyl, C8-C12 fused or bridged polycycloalkyl, or heterocyclic ring, where any of the preceding alkyl, cycloalkyl or heterocyclic ring groups may be singly or multiply substituted with X; R2 is H or R1; and X is halo, carbonyl carboxylic acid, carboxylic ester, carboxamide, substituted carboxamide, hydroxy, alkoxy, thioalkyl, sulphoxide, sulphone, sulphonamide, substituted sulphonamide, phenoxy, substituted phenoxy, phenyl, substituted phenyl, amino, substituted amino (including quaternary ammonium salts), N-oxide, imino, 5-7 membered heterocycle, or substituted heterocycle.
    Type: Application
    Filed: April 11, 2006
    Publication date: December 25, 2008
    Applicant: Murdoch University
    Inventors: Wayne Morris Best, Colette Gloria Sims, Richard Christopher Andrew Thompson, Simon Andrew Reid, Anthony Armson, James Alexander Reynoldson
  • Patent number: 7413580
    Abstract: The present application relates to a novel family of double para-phenylenediamines joined by a linker arm substituted with one or more carboxylic radicals and/or derivatives and to the use thereof for the dyeing of keratin fibres. These novel para-phenylenediamines are useful as oxidation bases for the dyeing of keratin fibres.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: August 19, 2008
    Assignee: L'Oreal S.A.
    Inventors: Thierry Bordier, Stéphane Sabelle
  • Publication number: 20080050795
    Abstract: A mixture of isolated or synthetic affinity molecules in a liquid carrier is disclosed. The mixture comprises at least two different affinity molecules, each with affinity for a predetermined analyte, for use in a single or multi flow cell piezoelectric crystal micro balance apparatus. Each isolated or synthetic affinity molecule forms together with the predetermined analyte an interaction pair selected from the group consisting of anion-cation, antibody-antigen, receptor-ligand, enzyme-substrate, oligonucleotide-oligonucleotide with complementary sequence, oligonucleotide-protein, oligonucleotide-cell, and peptide nucleic acid (PNA) oligomer-polynucleotide, wherein the polynucleotide may be selected from the group consisting of RNA, DNA and PNA polymers complementary to PNA oligomer. Use of the mixture for introduction into the liquid flow of a single or multi flow cell piezoelectric crystal micro balance apparatus is also described, as well as a kit containing the mixture.
    Type: Application
    Filed: November 19, 2004
    Publication date: February 28, 2008
    Applicant: Biosensor Applications Sweden AB
    Inventors: Per Mansson, Daniel Berggren, Carl Lundberg, Ann-Charlotte Hellgren, Lena Hojvall
  • Patent number: 7250523
    Abstract: Compounds and processes for catalytic ring-opening cyclooligomerization metathesis and ring-closing metathesis of olefins are described. The compound is a molybdenum or tungsten metal (M) complex which comprises an imido ligand (N—R) bound to the M to provide an M=N—R site, an M=C reaction site wherein the C of the M=C reaction site is tethered to the R of the imido ligand via a carbon or carbon and heteroatom (NOS) chain containing 1 to 12 carbon atoms to form a ring structure, and two to four ligands (R?) bound to the M to provide two to four M-R? sites. In particular embodiments, the M-R? sites include each of the oxygens of a dialkoxide ligand or each of the nitrogens of an ?1-pyrrolyl ligand bound to the M.
    Type: Grant
    Filed: October 22, 2003
    Date of Patent: July 31, 2007
    Assignee: Board of Trustees of Michigan State University
    Inventors: Aaron L. Odom, James T. Ciszewski
  • Patent number: 7250525
    Abstract: This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
    Type: Grant
    Filed: August 27, 2002
    Date of Patent: July 31, 2007
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Hank F. Kung, Mei-Ping Kung, Zhi-Ping Zhuang