Halogen, Bonded Directly To Carbon, Containing Patents (Class 564/442)
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Publication number: 20120196874Abstract: Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. The halogenated stilbene analogs include nitrogen heteroaryl groups and/or amino groups on the stilbene ring.Type: ApplicationFiled: January 27, 2012Publication date: August 2, 2012Inventors: David WATT, Chunming Liu, Vitaliy M. Sviripa, Wen Zhang
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Publication number: 20120165227Abstract: The present disclosure includes compounds of Formula I: wherein R1-R3, Ar, and n are as defined herein, and methods for the quantification of carboxylic acids in samples, specifically biological samples, using the compounds of Formula I. The compounds of Formula I are novel stable isotopic reagents that are useful in differential isotopic labeling methods.Type: ApplicationFiled: July 9, 2010Publication date: June 28, 2012Applicant: The Governors of the University of AlbertaInventors: Liang Li, Kun (Kevin) Guo
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Patent number: 8197722Abstract: Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.Type: GrantFiled: July 30, 2001Date of Patent: June 12, 2012Assignee: The California Institute of TechnologyInventors: Seth Marder, Joseph Perry
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Publication number: 20120142940Abstract: The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (?)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence.Type: ApplicationFiled: February 3, 2012Publication date: June 7, 2012Inventors: Jerry A. MURRY, Edward G. Corley, Feng Xu, Bryon Simmons
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Publication number: 20120095217Abstract: Fluorinated compounds and methods of making fluorinated compounds are described herein.Type: ApplicationFiled: January 8, 2010Publication date: April 19, 2012Inventors: Tobias Ritter, Laura Brass, Curtis Keith, Alan Watson, David J. Greenblatt
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Publication number: 20120071651Abstract: The present invention relates to processes for preparing enantiomerically pure cyclopropyl amine derivatives and salts thereof; the chiral intermediates such as the chiral salts are useful for the preparation of such chiral compounds and salts; pharmaceutical compositions comprising the compounds and salts; and method of using such compositions. The chiral cyclopropyl amine derivatives are useful for binding to histamine H3 receptor sites and for providing therapeutic agents for histamine H3 mediated disease.Type: ApplicationFiled: September 14, 2011Publication date: March 22, 2012Applicant: ABBOTT LABORATORIESInventors: Yi-Yin Ku, Timothy A. Grieme, Jeffrey M. Kallemeyn, Mathew M. Mulhern
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Publication number: 20120059163Abstract: In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a ?-donor conjugated to a ?-acceptor through a ?-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore-containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer.Type: ApplicationFiled: November 7, 2011Publication date: March 8, 2012Applicant: Optimer Photonics, Inc.Inventors: Vincent D. McGinniss, Steven M. Risser, Elizabeth Drotleff, Edward Jiang, Kevin B. Spahr
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Patent number: 8115032Abstract: A process for the preparation of the compound of formulaType: GrantFiled: March 28, 2011Date of Patent: February 14, 2012Assignee: Lonza Ltd.Inventors: Nicka Chinkov, Aleksander Warm, Erick Carreira
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Patent number: 8088952Abstract: A new ionic compound is provided that is derived from N,N-dimethylaniline and pentafluorophenol in amounts such that there are at least 2 equivalents of pentafluorophenol per equivalent of the N,N-dimethylaniline.Type: GrantFiled: July 2, 2007Date of Patent: January 3, 2012Assignee: Albemarle CorporationInventors: Lubin Luo, Zhike Wang, Steven P. Diefenbach, Xiao Wu
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Publication number: 20110295020Abstract: The present invention is concerned with novel processes for the preparation of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof, and (?)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., depression, anxiety disorders, eating disorders and urinary incontinence.Type: ApplicationFiled: August 10, 2011Publication date: December 1, 2011Inventors: Jerry A. MURRY, Edward G. CORLEY, Feng XU, Bryon SIMMONS
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Patent number: 8017771Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.Type: GrantFiled: January 16, 2009Date of Patent: September 13, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Carl Alan Busacca, Rogelio Perez Frutos, Nizar Haddad, Suresh R. Kapadia, Jon Charles Lorenz, Anjan Saha, Chris Hugh Senanayake, Xudong Wei
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Publication number: 20110195979Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.Type: ApplicationFiled: February 7, 2011Publication date: August 11, 2011Inventors: Li Chen, Xianfeng Lin, Zongxing Qiu, Guozhi Tang, Lisha Wang, Jim Zhen Wu, Wengang Yang
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Publication number: 20110172464Abstract: A process for the preparation of the compound of formulaType: ApplicationFiled: April 9, 2010Publication date: July 14, 2011Inventors: Nicka Chinkov, Aleksander Warm, Erick Carreira
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Publication number: 20110105766Abstract: A process for preparing substituted biphenyls of the formula I where R1=nitro or amino, R2=cyano, halogen, C1-C4-haloalkyl, C1-C4-haloalkoxy or C1-C4-haloalkylthio, n=from 0 to 3, and R3=hydrogen, cyano or halogen, which comprises reacting a halobenzene of the formula II in which Hal is chlorine or bromine, in the presence of a base and of a palladium catalyst which consists of palladium and a bidentate phosphorus ligand of the formula III where Ar is phenyl which is substituted if desired and R4 and R5 are each C1-C8-alkyl or C3-C6-cycloalkyl or together form a 2- to 7-membered bridge which may, if desired, bear a C1-C6-alkyl substituent, in a solvent or diluent, with a phenylboronic acid IVa a diphenylborinic acid IVb or a mixture of IVa and IVb.Type: ApplicationFiled: June 22, 2009Publication date: May 5, 2011Applicant: BASF SEInventors: Sebastian Peer Smidt, Volker Maywald, Kathrin Wissel-Stoll, Joachim Schmidt-Leithoff, Ansgar Gereon Altenhoff, Michael Keil
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Patent number: 7932348Abstract: Polymers made by polymerization or cyclization condensation of a fluorine-containing polymerizable monomer represented by the formula [1] wherein “a” represents an integer from 1 to 4. The monomer contains a plurality of polymerizable amines in the molecule and at the same time one or more hexafluoroisopropyl group(s). With this structure it can be used as an effective polymerizable monomer, which can exhibit water repellency, oil repellency, low water absorptive property, heat resistance, weather resistance, corrosion resistance, transparency, photosensitivity, low refractive index property, low dielectric property, etc., and it can be used for advanced polymer material fields.Type: GrantFiled: May 26, 2010Date of Patent: April 26, 2011Assignee: Central Glass Company, LimitedInventors: Hiroshi Saegusa, Satoru Narizuka, Kazuhiko Maeda
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Publication number: 20110077400Abstract: Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form.Type: ApplicationFiled: June 4, 2009Publication date: March 31, 2011Inventors: Paul Lobben, Rulin Zhao, Bei Wang, Bang-Chi Chen, Shuang Liu, Min Hu, Yuh-Lin Allen Yang, Matthew Isherwood, Rasidul Amin, Wenge Cui
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Publication number: 20110054218Abstract: A process for preparing a compound of formula (V) or its enantiomer, which comprises: (a) reacting racemic aminoindan of formula (II) or its enantiomer with allylhalide in presence of a base and an organic solvent at a temperature ranging from 25 C to the reflux temperature of the solvent to give compound of formula (III); Where R is H or (b) reacting the compound (III) with halogenating agent in a suitable organic solvent to give a dihalo compound of formula (IV). (c) treating the dihalo compound (IV) with a suitable base to give compound (V).Type: ApplicationFiled: December 19, 2008Publication date: March 3, 2011Applicant: CIPLA LIMITEDInventors: Manjinder Singh Phull, Dharmaraj Ramachandra Rao, Rajendra Narayanrao Kankan
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Publication number: 20110053778Abstract: 2-(3-Aminobenzoyl)-3-cyclopropyl-3-oxopropanenitriles of the formula (I) are described as herbicides. In this formula (I), X and Y are organic radicals such as alkyl and other radicals such as halogen, nitro and cyano.Type: ApplicationFiled: July 27, 2010Publication date: March 3, 2011Applicant: BAYER CROPSCIENCE AGInventors: Hartmut AHRENS, Ines Heinemann, Andreas Van Almsick, Ralf Braun, Jan Dittgen, Dieter Feucht, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Stefan Lehr
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Publication number: 20100331566Abstract: The invention provides synthetic methods that utilize bromo or chloro substituents as blocking groups during the functionalization of aromatic rings, as well as compounds that are prepared from such methods.Type: ApplicationFiled: June 25, 2010Publication date: December 30, 2010Inventors: Leslie S. Jimenez, Ahalya Ramanathan
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Publication number: 20100311710Abstract: The present invention relates to new cyclobutanemethanamine inhibitors of monoamine reuptake, pharmaceutical compositions thereof, and methods of use thereof.Type: ApplicationFiled: December 4, 2009Publication date: December 9, 2010Applicant: AUSPEX PHARMACEUTICALS, INC.Inventors: Thomas G. Gant, Sepehr Sarshar, Manouchehr M. Shahbaz
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Publication number: 20100311974Abstract: Substituted pyrazinecarboxylic acid anilide derivatives represented by the general formula (I) or salts thereof; intermediates of them; pesticides (such as insecticides and acaricides) for agricultural and horticultural use, containing the compounds as the active ingredient; and usage thereof: wherein R1 is H, C1-6 alkyl, halo C1-6 alkyl, or the like; R2 is halogeno, C1-6 alkyl, or the like; G is C2-10 alkyl or the like; Z is oxygen or sulfur; X's are each independently H, halogeno, or the like; Y's are each independently H, halogeno, cyano, or the like; and m and n are each an integer of 1 to 3.Type: ApplicationFiled: July 29, 2010Publication date: December 9, 2010Inventors: Takashi FURUYA, Kozo Machiya, Akiyuki Suwa, Shinsuke Fujioka
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Publication number: 20100292478Abstract: A process of preparing a radioactive compound containing a fluorine-18 isotope is provided. In one embodiment, the process may comprise forming a [18F] fluoroalkyl triflate by triflating a [18F] fluoroalkyl compound with AgOTf, and forming a [18F] fluoroalkylated radioactive compound through alkylation between the [18F] fluoroalkyl triflate and a radioactive compound precursor having at least one group selected from NH, OH and SH.Type: ApplicationFiled: March 29, 2010Publication date: November 18, 2010Applicant: GACHON UNIVERSITY OF MEDICINE & SCIENCE INDUSTRY- ACADEMIC COOPERATION FOUNDATIONInventors: Zang Hee CHO, Young Bo Kim, Sang Yoon LEE, So Hee KIM
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Publication number: 20100286408Abstract: An efficient method to induce the enantioselectivity in procarbonyl compounds using chiral organometallic complexes. The present invention is also described a method for producing organo metallic complexes using a base and a metal halide.Type: ApplicationFiled: July 30, 2008Publication date: November 11, 2010Applicant: Aptuit Laurus Pvt. Ltd.Inventors: Chava Satyanarayana, Bollu Ravindra Babu
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Publication number: 20100278733Abstract: There is provided a composition comprising a compound represented by general formula (I), wherein Rl represents a 5-iodothiophen-2-yl group or the like, and R2 represents a 4-dimethylaminophenyl group or the like. This composition is useful for diagnosis of an amyloid-related disease such as Alzheimer's disease because the compound has high binding specificity to amyloid ? protein, high permeability through the blood-brain barrier, and a property of being rapidly eliminated from sites other than senile plaques in the brain.Type: ApplicationFiled: May 22, 2007Publication date: November 4, 2010Inventors: Morio Nakayama, Mamoru Haratake, Masahiro Ono
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Patent number: 7825280Abstract: The present invention relates to a fluorine-containing polymerizable monomer represented by the formula [1], [Chem. 31] wherein “a” represents an integer of 1-4. This monomer has a plurality of polymerizable amines in the molecule and at the same time a hexafluoroisopropyl group(s). With this, it can be used as an effective polymerizable monomer, which can exhibit water repellency, oil repellency, low water absorptive property, heat resistance, weather resistance, corrosion resistance, transparency, photosensitivity, low refractive index property, low dielectric property, etc., and can be used for advanced polymer material fields.Type: GrantFiled: October 17, 2005Date of Patent: November 2, 2010Assignee: Central Glass Company, LimitedInventors: Hiroshi Saegusa, Satoru Narizuka, Kazuhiko Maeda
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Publication number: 20100266500Abstract: This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.Type: ApplicationFiled: April 22, 2010Publication date: October 21, 2010Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Hank F. Kung, Mei-Ping Kung, Zhi-Ping Zhuang
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Publication number: 20100240712Abstract: Novel aromatic compounds of formula (I): wherein A1, A2, A3, A4, R1, R2, R5, G1, G2, Q1, Q2, Y1, Y2, Y3 and Y4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal or molluscicidal compositions comprising them and to methods of using them to combat and control insect, acarine, nematode or mollusc pests.Type: ApplicationFiled: October 13, 2008Publication date: September 23, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Andre Denis Stoller, Pierre Joseph Marcel Jung, Christopher Richard Ayles Godfrey, William Lutz, Peter Maienfisch, Werner Zambach
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Patent number: 7786177Abstract: Phenylalanine enamide derivatives of formula (1) are described: wherein R1 is a group Ar1 L2Ar2Alk- in which: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a covalent bond or a linker atom or group; Ar2 is an optionally substituted arylene or heteroarylene group; and Alk is a chain —CH2—CH(R)—, —CH?C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof; X is an —O— or —S— atom or —N(R2)— group in which: Rx, Ry and Rz which may be the same or different is each a hydrogen atom or an optional substituent; or Rz is an atom or group as previously defined and Rx and Ry are joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group; and the salts, solvates, hydrates and N-oxides thereof.Type: GrantFiled: March 31, 2009Date of Patent: August 31, 2010Assignee: UCB Pharma S.A.Inventors: Stephen Brand, Stuart Bailey, Julien A. Brown, James A. Johnson, John R. Porter, John C. Head
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Patent number: 7786098Abstract: Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.Type: GrantFiled: November 22, 2006Date of Patent: August 31, 2010Assignee: Zhejiang Dade Pharmaceutical Group Co. Ltd.Inventors: Weiping Shen, Jianping Wang, Jianguo Wang, Hongmei Jin, Feng Qian, Fei Wang
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Publication number: 20100217034Abstract: Disclosed herein is an improved, commercially viable and industrially advantageous process for the preparation of Fesoterodine or a pharmaceutically acceptable salt thereof in high yield and purity. Disclosed also herein is an improved and industrially advantageous optical resolution method of racemic (±)-N,N-Diisopropyl-3-(2-benzyloxy-5-bromophenyl)-3-phenylpropylamine and use thereof for the preparation of Fesoterodine.Type: ApplicationFiled: September 22, 2008Publication date: August 26, 2010Applicant: ACTAVIS GROUP PTC EHFInventors: Kishore Charugundla, Udhaya Kumar, Rajendra Suryabhan Patil, Praveen Kumar Neela, Nitin Sharadchandra Pradhan, Jon Valgeirsson
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Publication number: 20100204470Abstract: The present invention provides a new method for preparation and crystallization of hydrochlorides, hydrobromides or hydroiodides of pharmaceutical compounds or their intermediates in which the base or its acid addition salt is reacted in a solvent with a Trialkylsilylhalogenide.Type: ApplicationFiled: June 25, 2007Publication date: August 12, 2010Inventors: Josef Wieser, Hannes Lengauer, Elfriede Klingler, Arthur Pichler, Hubert Sturm
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Publication number: 20100190861Abstract: The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.Type: ApplicationFiled: January 15, 2010Publication date: July 29, 2010Inventors: Liming Shao, Fengjiang Wang, Scott Christopher Malcolm, Michael Charles Hewitt, Larry R. Bush, Jianguo Ma, Mark A. Varney, Una Campbell, Sharon Rae Engel, Larry Wendell Hardy, Patrick Koch, John E. Campbell
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Publication number: 20100185015Abstract: The present invention relates to a process for preparing biaryls using catalysts based on palladium compounds with phosphine ligands.Type: ApplicationFiled: June 27, 2008Publication date: July 22, 2010Applicant: Bayer CropScience AGInventors: Alexander Straub, Norbert Lui, Juergen Wieschemeyer, Ulrich Kloettschen, Eric Wihelus Petrus Damen
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Publication number: 20100179221Abstract: A fluorine-substituted amphetamine or amphetamine derivative with the formula (I): where at least one of the residues R1 or R2 is different from H and Ph is a phenyl ring, which is substituted with fluorine in at least one position or the residues R1 and R2 independently of one another are H or are different from H and Ph is a phenyl ring, which is substituted with fluorine in at least three positions or the residues R1 and R2 independently of one another are H or are different from H and Ph is a phenyl ring, which is substituted with fluorine in at least one position and has a substituent different from H in at least one other position.Type: ApplicationFiled: March 19, 2008Publication date: July 15, 2010Applicant: Universitat TubingenInventors: Ulrich Nagel, Werner Jürgen Schmidt
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Publication number: 20100113605Abstract: The invention relates to a method for identifying a candidate compound for treating a disorder or condition associated with dysfunction of monoamine neurotransmission in the central nervous system, the method comprising the following steps: (a) providing a compound to be tested; (b) testing the ability of the compound to bind to the cocaine-binding site of a monoamine reuptake transporter; and (c) testing the ability of the compound to modulate the inward or outward transport of monoamine neurotransmitters via the monoamine reuptake transporter, wherein the test compound is identified as a candidate compound for treating a disorder or condition associated’ with dysfunction of monoamine neurotransmission if it is able to bind to the cocaine-binding site of the monoamine reuptake transporter and modulate its activity. The invention further relates to compounds identified using the method of the invention, and uses, compositions and medicaments thereof.Type: ApplicationFiled: March 28, 2008Publication date: May 6, 2010Inventor: David John HEAL
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Publication number: 20100004297Abstract: The invention is concerned with novel hexafluoroisopropanol derivatives of formula (I) wherein R1 to R6, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds bind to LXR alpha and LXR beta and can be used as medicaments.Type: ApplicationFiled: September 10, 2009Publication date: January 7, 2010Inventors: Henrietta Dehmlow, Bernd Kuhn, Raffaello Masciadri, Narendra Panday, Hasane Ratni, Matthew Blake Wright
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Publication number: 20090326273Abstract: A new ionic compound is provided that is derived from N,N-dimethylaniline and pentafluorophenol in amounts such that there are at least 2 equivalents of pentafluorophenol per equivalent of the N,N-dimethylaniline.Type: ApplicationFiled: July 2, 2007Publication date: December 31, 2009Applicant: Albemarle CorporationInventors: Lubin Luo, Zhike Wang, Steven P. Diefenbach, Xiao Wu
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Publication number: 20090302273Abstract: A liquid crystal compound represented by formula (1), a liquid crystal composition comprising the compound, and a liquid crystal display device comprising the composition: For example, R1 is alkyl having 1 to 20; ring A1, ring A2, ring A3, ring A4, ring A5, and ring A6 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2, Z3, Z4, Z5, and Z6 is a single bond; X1 is hydrogen or halogen; l, m, n, o, p, and q are 0 or 1, and l+m+n+o+p+q is 3.Type: ApplicationFiled: June 4, 2009Publication date: December 10, 2009Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATIONInventor: HIROYUKI TANAKA
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Publication number: 20090291988Abstract: The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.Type: ApplicationFiled: June 14, 2006Publication date: November 26, 2009Inventor: Renata Oballa
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Publication number: 20090203901Abstract: The present invention provides innovative strategies for synthesizing pyrazole ring-functionalized benzodiazepinones. Alternative intermediates and high conversion strategies for forming alpha-aminobenzophenone intermediates involve a combination of aromatic acylation, displacement of electronegative leaving groups with amine, and then N-displacement strategies to produce the desired alpha-aminobenzophenone with primary amine functionality. Reaction strategies are then provided for converting alpha-aminobenzophenones to alpha-aminoamidobenzophenone intermediates with high yield and convenient reaction strategies. These alpha-aminoamidobenzophenone intermediates are then converted into benzodiazepinones. These benzodiazepinones are then converted to pyrazole ring functionalized benzodiazepinones through a series of innovative intermediates and/or reaction strategies.Type: ApplicationFiled: February 12, 2009Publication date: August 13, 2009Inventors: Peter J. Harrington, Valerie Grace Paulsen, Charles E. Tucker
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Publication number: 20090197201Abstract: The present invention relates to the use of end groups Y, where Y stands for (formula I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)r—, [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, as end group in surface-active compounds, to corresponding novel compounds, and to processes for the preparation of these compounds.Type: ApplicationFiled: July 2, 2007Publication date: August 6, 2009Inventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
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Publication number: 20090177012Abstract: A process for producing an ?,?-difluoroamine which comprises using hydrogen fluoride and a Lewis base in specific amounts in the halogen-fluorine exchange reaction using an ?,?-dihaloamine as the substrate. The process can be industrially applied, enables to obtain the object compound in a short time at a great yield and can be conducted easily with excellent productivity.Type: ApplicationFiled: October 20, 2005Publication date: July 9, 2009Inventors: Tsuyoshi Fukuhara, Shoji Hara, Toshio Hidaka
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Patent number: 7553993Abstract: Process for the preparation of a compound of general formula (I): in which X represents a halogen atom, by reaction of para-trifluoromethylaniline of formula (II): with a dihalogen X2, the two compounds being introduced simultaneously into a polar aprotic solvent in a dihalogen/compound (II) molar ratio ranging from 1.9 to 2.5 and at a temperature ranging from 100 to 300° C.Type: GrantFiled: October 24, 2003Date of Patent: June 30, 2009Assignees: BASF Agro B.V., Wadenswil/AUInventors: Bernard Buathier, Pierre Le Roy
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Publication number: 20090156804Abstract: The present invention relates to a production method of an optically active morpholine compound represented by the formula 10, which includes the following steps: wherein each symbol is as defined in the specification. The present invention also relates to a production method of an compound represented by the formula 55, which includes the following steps: wherein each symbol is as defined in the specification. According to the production method of the present invention, an optically active 2-aryl-substituted morpholine compound and 3-oxo-3-(pyrimidin-4-yl)propionate, which are important as starting materials for synthesizing 2-(2-arylmorpholin-4-yl)-1-methyl-1H-[4,4?]bipyrimidinyl-6-one having a tau protein kinase 1 inhibitory activity and useful as a therapeutic drug for Alzheimer's disease and the like, can be produced in a high yield by an industrially advantageous method.Type: ApplicationFiled: July 21, 2006Publication date: June 18, 2009Applicants: MITSUBISHI TANABE PHARMA CORPORATION, SANOFI-AVENTISInventors: Masahiro Okuyama, Fumiaki Uehara, Hiroshi Iwamura, Kazutoshi Watanabe
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Publication number: 20090124809Abstract: Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.Type: ApplicationFiled: January 16, 2009Publication date: May 14, 2009Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Carl Alan BUSACCA, Rogelio Perez FRUTOS, Nizar HADDAD, Suresh R. KAPADIA, Jon Charles LORENZ, Anjan SAHA, Chris Hugh SENANAYAKE, Xudong WEI
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Publication number: 20090118375Abstract: Novel optically active phthalamides of the formula (I) in which A, q, R1, R2, E1, E2, X, m, Y, n and Z are as defined in the description, processes for preparing these compounds and their use for controlling pests.Type: ApplicationFiled: August 20, 2005Publication date: May 7, 2009Inventors: Rudiger Fischer, Christian Funke, Olga Malsam, Peter Losel, Ulrich Gorgens, Christian Arnold, Masanori Tohnischi, Minoru Yamaguchi, Hiroto Harayama, Shinsuke Fujioka
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Publication number: 20090076159Abstract: The present application describes deuterium-enriched eplivanserin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: ApplicationFiled: September 15, 2008Publication date: March 19, 2009Applicant: PROTIA, LLCInventor: Anthony W. Czarnik
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Publication number: 20090023886Abstract: Disclosed is a fluorine-containing polymerizable monomer represented by the formula [1] below. (In the formula [1], a represents an integer of 1-4.) By having a plurality of polymerizable amines in a molecule while containing a hexafluoroisopropyl group, this fluorine-containing polymerizable monomer exhibiting water repellancy, oil repellency, low water absorbency, heat resistance, weather resistance, corrosion resistance, transparency, photosensitivity, low refractive index, low dielectric properties, and the like, and thus can be applied to the field of advanced polymer materials.Type: ApplicationFiled: October 17, 2005Publication date: January 22, 2009Applicant: Central Glass Company, LimitedInventors: Hiroshi Saegusa, Satoru Narizuka, Kazuhiko Maeda
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Publication number: 20080312473Abstract: The process of the present invention can be briefly summarized as depicted in the following scheme: R1 is C1-Calkyl, R2 is C1-C6alkyl and Hal is a halogen atom.Type: ApplicationFiled: January 18, 2007Publication date: December 18, 2008Inventors: Jinhua J. Song, Jinghua Xu
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Publication number: 20080306027Abstract: Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.Type: ApplicationFiled: November 22, 2006Publication date: December 11, 2008Applicant: Zhejiang Dade Pharmaceutical Group Co., Ltd.Inventors: Weiping Shen, Jianping Wang, Jianguo Wang, Feng Qian, Fei Wang, Hongmei Jin