Benzene Ring Containing Compound With Preservative Or Stabilizer Patents (Class 564/5)
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Patent number: 8741959Abstract: The invention relates to an aqueous pharmaceutical composition, preferably an infusion solution, for parenteral administration which contains paracetamol and has an electrical conductivity of not more than 200 ?S cm?1.Type: GrantFiled: April 19, 2010Date of Patent: June 3, 2014Assignee: Fresenius Kabi Deutschland GmbHInventors: David Dasberg, Georg Achleitner, Christiane Aichholzer
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Patent number: 8404891Abstract: The present invention concerns a liquid formulation that is stable to oxidation and that is based on paracetamol in an aqueous solvent obtainable by the following steps: (i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65° C. and 95° C., and having pH between 5.0 and 6.0; (ii) cooling the solution so formed to a temperature equal to or above 35° C. and below 40° C. under an atmosphere of nitrogen; (iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring; (iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere. It further relates to a method for preparing the formulation.Type: GrantFiled: September 3, 2010Date of Patent: March 26, 2013Assignee: Neogen N.V.Inventor: Khaled Al Dandachi Atassi
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Patent number: 8178121Abstract: The present invention refers to ready-to-use highly stable paracetamol injectable solutions, prepared by mixing paracetamol, water, propylene glycol, and a citrate buffer. (pH 4.5 to 6.5), and by heating said solution under preset conditions. The resulting solution may be stored for an extended period of time within a wide range of temperatures, with no paracetamol precipitation and/or its chemical modification.Type: GrantFiled: October 15, 2002Date of Patent: May 15, 2012Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventor: Tho Nguyen-Xuan
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Publication number: 20120077211Abstract: Compositions, assays, methods, and kits are disclosed for use in applications that utilize oxidation of a chromogenic electron donor such as diaminobenzidine (DAB) to generate a signal. Applications include, but are not limited to, immunohistochemistry, chromogenic in situ hybridization, Western blots, Northern blots, Southern blots, ELISA assays, and microarray detection. The compositions, assays, methods, and kits disclosed herein make use of a novel, stabilized formulation of DAB and a novel, stabilized formulation of hydrogen peroxide.Type: ApplicationFiled: December 15, 2009Publication date: March 29, 2012Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Lawrence Greenfield, Shawn Starkenburg, Matthew Shallice, Julie Nyhus, Louis Leong
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Publication number: 20110172321Abstract: The invention relates to innovative viscosity stabilizers for hotmelts, to melt-viscosity-stable hotmelts comprising these viscosity stabilizers, to a process for preparing them and to their use.Type: ApplicationFiled: October 6, 2010Publication date: July 14, 2011Applicant: RHEIN CHEMIE RHEINAU GmbHInventors: Wilhelm Laufer, Bernd Kray, Peter Schuster, Christian Scheffner, Serdar Uestuenbas, Marc Leimenstoll, Peter Reichert, Eduard Mayer, Matthias Wintermantel
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Patent number: 7402698Abstract: The present invention is directed to secondary amino- and cycloamino-cycloalkanol derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.Type: GrantFiled: October 12, 2004Date of Patent: July 22, 2008Assignee: WyethInventors: Paige Erin Mahaney, Michael Byron Webb, Lori Krim Gavrin, Eugene John Trybulski
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Patent number: 6992218Abstract: A method for obtaining aqueous formulations with easily oxidizable active principles, notably phenols, stable over a prolonged period, comprising subjecting them to extreme deoxygenation by bubbling with an inert gas and/or placing wider vaccum, protecting them against possible resorption of oxygen by keeping them under an inert gas atmosphere, by filling, under inert gas, into bottles previously cleared of air by insufflation with inert gas, then subjecting them, while stoppering, to low pressure as obtained in the bottle, of 65,000 Pa maximum, to obtain aqueous solutions having a residual oxygen concentration in the solution below 2 ppm, and preferably of the order of 1 ppm and even 0.5 ppm useful as injectable preparations having an oxygen concentration in the solution below 2 ppm.Type: GrantFiled: June 6, 2001Date of Patent: January 31, 2006Assignee: Pharmatop SCRInventors: Francois Dietlin, Daniele Fredj
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Patent number: 6340772Abstract: Three processes are described for preparing (hetero)aromatic substituted benzene derivatives which comprise aromatization of cyclohexenone derivatives via (chloro)cyclohexadiene derivatives.Type: GrantFiled: April 24, 2001Date of Patent: January 22, 2002Assignee: Nippon Kayaku Co., Ltd.Inventors: Tetsuya Toya, Hidetoshi Shirakura, Junichi Kon
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Publication number: 20010020112Abstract: Three processes are described for preparing (hetero)aromatic substituted benzene derivatives which comprise aromatization of cyclohexenone derivatives via (chloro)cyclohexadiene derivatives.Type: ApplicationFiled: April 24, 2001Publication date: September 6, 2001Inventors: Tetsuya Toya, Hidetoshi Shirakura, Junichi Kon
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Patent number: 6028222Abstract: Novel stable paracetamol compositions for use in therapeutic chemistry and specifically galenic pharmacy are disclosed. The compositions contain a solution of paracetamol in an aqueous solvent combined with a buffer having a pH of 4 to 8, and a free radical capturing agent. A water-insoluble inert gas is carefully bubbled through the aqueous solvent to remove oxygen from the medium. Said compositions may also be combined with a centrally or peripherally acting analgesic agent, and are provided as injectable compositions for relieving pain.Type: GrantFiled: June 5, 1998Date of Patent: February 22, 2000Assignee: SCR PharmatopInventors: Francois Dietlin, Daniele Fredj
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Patent number: 5942151Abstract: A process for the production of polymethylene polyphenyl polyisocyanates is disclosed. The process comprises phosgenating the corresponding polyamines in solution in an inert organic solvent, removing excess phosgene, and stripping the solvent, the improvement wherein at least 0.00015 percent by weight of hydrazine or hydrazine derivative per 100 percent by weight of polyamine are added to the polyamines at any time prior to the stripping step.Type: GrantFiled: November 20, 1997Date of Patent: August 24, 1999Assignee: Bayer CorporationInventors: Rick L. Adkins, Clarence D. Blue
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Patent number: 5888473Abstract: Boron neutron capture therapy can utilize X.sub.y B.sub.20 H.sub.17 L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH.sub.3, and Na.sub.2 B.sub.10 H.sub.9 NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may have embedded within their bilayers carboranes to increase the amount of delivered .sup.10 B and/or to increase the tumor specificity of the liposome.Type: GrantFiled: August 3, 1995Date of Patent: March 30, 1999Assignee: The Regents of the University of CaliforniaInventors: M. Frederick Hawthorne, Debra Arliene Feakes, Kenneth John Shelly
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Patent number: 5872292Abstract: This invention relates to stable aromatic amine compositions. These compositions comprise a) a compound selected from the group consisting of aldehydes, ketones, acetals and ketals, and b) an aromatic amine. This invention also relates to a process for stabilizing the color of aromatic amines, and to the use of these aromatic amines as initiators for the preparation of polyether polyols.Type: GrantFiled: January 24, 1997Date of Patent: February 16, 1999Assignee: Bayer CorporationInventors: Rick L. Adkins, Steven L. Schilling, Keith J. Headley
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Patent number: 5840984Abstract: Odor formation during storage of (hydrocarbylthio)aromatic amines due to formation and release of odoriferous sulfur-containing species such as dihydrocarbyldisulfides, is suppressed. To accomplish this, a small amount of N,N-dihydrocarbylhydroxylamine odor-inhibitor (e.g., N,N-diethylhydroxylamine) is blended with the (hydrocarbylthio)aromatic amine. This enables products such as a mixture of 3,5-di(methylthio)-2,4-diaminotoluene and 3,5-di(methylthio)-2,6-diaminotoluene) to be stored for long periods of time with significantly reduced formation and release of odoriferous sulfur-containing species.Type: GrantFiled: June 23, 1997Date of Patent: November 24, 1998Assignee: Albemarle CorporationInventors: Gregory H. Lambeth, Paul L. Wiggins, William R. Brown
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Patent number: 5693862Abstract: The present invention is directed to a process for transporting toluenediamine (TDA) from a first site to a second site. The process of the invention comprises the steps of (a) providing a molten mass of TDA isomers at the first site; (b) cooling the molten mass to a temperature below the melting point, the molten mass thereby forming flowable particles of solid TDA in an inert gas; (c) providing an airtight storage vessel lined with a chemically inert liner; (d) storing the flowable particles of solid TDA in the lined storage vessel; (e) charging the storage vessel with inert gas; (f) transporting the storage vessel from the first site to the second site; and (g) remelting the TDA flowable particles in inert gas with TDA liquid that is superheated above the melting point to produce a molten TDA isomer mixture in inert gas having substantially the same isomer ratio as that of the molten mass.Type: GrantFiled: December 18, 1996Date of Patent: December 2, 1997Assignee: Arco Chemical Technology, L.P.Inventors: Majid Keyvani, Rekha Menon, James L. Meyer, Thomas W. Offill
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Patent number: 5670692Abstract: Ethylenically unsaturated monomers are protected from premature polymerization during manufacture and storage by the incorporation therein of an effective stabilizing amount of a 7-substituted quinone methide compound.Type: GrantFiled: August 27, 1996Date of Patent: September 23, 1997Assignee: Ciba-Geigy CorporationInventors: Peter Nesvadba, Samuel Evans, Matthew E. Gande, Volker H. von Ahn, Roland A. E. Winter
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Patent number: 5495046Abstract: An alkoxyphenylalkylamine derivative represented by the following formula: ##STR1## (wherein X.sup.1 and X.sup.2 may be either the same or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkoxy group having 1 to 5 carbon atoms and substituted with a phenyl group; R.sup.1 and R.sup.2 may be either the same or different from each other and each represents a hydrogen atom, an alkyl group having 1 to 7 carbon atoms, an alkyl group having 1 to 7 carbon atoms and substituted with "a hydroxyl group, a carboxyl group or an alkoxycarbonyl group" at the end, or, R.sup.1 and R.sup.Type: GrantFiled: March 31, 1994Date of Patent: February 27, 1996Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Atsuro Nakazato, Yoshinori Sekiguchi, Koumei Ohta, Yutaka Kawashima, Katsuo Hatayama
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Patent number: 5454973Abstract: Mineral acid slurries of benzidine derivatives having high stability are provided by incorporating into such slurries a polysaccharide.Type: GrantFiled: October 14, 1993Date of Patent: October 3, 1995Assignee: Wakayama Seika Kogyo Co., Ltd.Inventors: Fumio Koseki, Kenjiro Fujiki, Motonori Takeda, Katsutoshi Tao
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Patent number: 5349104Abstract: Without added stabilizers, aminobenzotrifluorides have low thermal and storage stability.The present invention relates to preparations of a stabilized amionbenzotrifluoride, composed essentially ofa) an aminobenzotrifluoride of the formula (I), ##STR1## in which R.sup.1 and R.sup.2, independently of each other, are hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, substituted or unsubstituted aryl, halogen, CF.sub.3, nitro, amino, methoxy, hydroxyl or NR.sup.3 R.sup.4, where R.sup.3 and R.sup.4, independently of each other, are hydrogen or C.sub.1 -C.sub.5 -alkyl radicals, and the NH.sub.2 group can be located in the 2-, 3- or 4-position in relation to the CF.sub.3 group, andb) at least one base.Type: GrantFiled: May 4, 1993Date of Patent: September 20, 1994Assignee: Hoechst AktiengesellschaftInventors: Gilbert Billeb, Gunther Semler
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Patent number: 5223644Abstract: Bicarbonates and/or carbonates are used in greater than catalytic amounts to inhibit the formation of nitrosamines during the preparation, storage and/or use of amine oxides.Type: GrantFiled: February 3, 1992Date of Patent: June 29, 1993Assignee: Albright & Wilson LimitedInventors: Michael Blezard, Glyn R. Jones
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Patent number: 4990663Abstract: This invention relates to a process for the hydrogenation of halogenated aromatic nitro compounds to the corresponding halogenated amines using a platinum catalyst in the presence of certain aminoalkyl ethers or alkanolamines. It relates in addition to halogenated aromatic amines containing an amount of such aminoalkyl ether or alkanolamine effective to stabilize said halogenated aromatic amine. The storage stabilizers and dehalogenation inhibitors contain a total of 2 to 6 carbon atoms and can be represented by the formula:R.sup.1 --(R.sup.2)--N--(CH.sub.2).sub.n --O--R.sup.3wherein R.sup.1 and R.sup.2 may be the same or different --H or --CH.sub.2 CH.sub.2 OH, n is an integer from 2 to 3, and R.sup.3 is either --H or --CH.sub.3.Type: GrantFiled: May 15, 1989Date of Patent: February 5, 1991Assignee: E. I. Du POnt de Nemours and CompanyInventors: Yu-Wei Chang, Robert L. Seagraves
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Patent number: 4970343Abstract: A one-step process for the preparation of nitrosamine-free dinitroaniline herbicides which involves contacting the crude dinitroaniline herbicide in the liquid state, after removal of excess amine, with an effective quantity of a hydrobromide salt of a p-amino benzoate ester, optionally in the presence of such an ester, passing a gaseous stream of air therethrough or applying a reduced pressure so as to essentially remove water present, resulting in an essentially nitrosamine-free product.Type: GrantFiled: June 15, 1987Date of Patent: November 13, 1990Assignee: Agan Chemical Manufacturers Ltd.Inventors: Michael Pikarski, Edmund Dykman
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Patent number: 4559408Abstract: A cyclohexylmethyleneimine compound represented by the following general formula: ##STR1## wherein R is an alkyl group bonded to individual carbon atom of the cyclohexyl ring and n is an integer of 0 to 5, or a methyleneimine composition containing at least the cyclohexylmethyleneimine compound can be stabilized by an organic lithium compound represented by the following general formula:R'--Li,wherein R' is an alkyl, aryl or aralkyl group, and can be preserved stably for a long time.Type: GrantFiled: January 3, 1985Date of Patent: December 17, 1985Assignee: Mitsubishi Gas Chemical Co., Inc.Inventors: Toshiaki Nishimura, Masahiro Kurokawa
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Patent number: 4331468Abstract: Process for inhibiting formation of nitrosamines in nitro herbicide formulations containing (a) materials having nitrosatable nitrogen functional groups and (b) nitrosating agents or precursors thereof, comprising admixing with one or more ingredients of such formulations, prior to formation of nitrosamines, nitrosamine retarding amounts of at least one monoalkanolamine of the formula: ##STR1## where n is a whole number in the range of 0-5; R and R' are independently H or an alkyl group containing 1-5 carbon atoms; or at least one acid salt of said monoalkanolamines.Type: GrantFiled: April 22, 1981Date of Patent: May 25, 1982Assignee: The Dow Chemical CompanyInventor: Michael L. Williams
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Patent number: 4273937Abstract: Organic amine compositions which are substantially free of nitrosamine contaminants are provided which comprise an organic amine and an inhibiting amount of an inhibitor additive selected from the group consisting of 1,4-naphthoquinone, 1,4-naphthohydroquinone, alkyl-derivatives of said quinones, and mixtures of the same.Type: GrantFiled: December 19, 1979Date of Patent: June 16, 1981Assignee: Union Carbide CorporationInventors: Mary L. Gum, Nancye D. Kearns