Inorganic Preservative Or Stabilizer Patents (Class 564/6)
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Patent number: 8741959Abstract: The invention relates to an aqueous pharmaceutical composition, preferably an infusion solution, for parenteral administration which contains paracetamol and has an electrical conductivity of not more than 200 ?S cm?1.Type: GrantFiled: April 19, 2010Date of Patent: June 3, 2014Assignee: Fresenius Kabi Deutschland GmbHInventors: David Dasberg, Georg Achleitner, Christiane Aichholzer
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Patent number: 8404891Abstract: The present invention concerns a liquid formulation that is stable to oxidation and that is based on paracetamol in an aqueous solvent obtainable by the following steps: (i) dissolving in a reaction vessel paracetamol in an aqueous solvent having a temperature between 65° C. and 95° C., and having pH between 5.0 and 6.0; (ii) cooling the solution so formed to a temperature equal to or above 35° C. and below 40° C. under an atmosphere of nitrogen; (iii) adding cysteine hydrochloride and sodium hydroxide simultaneously to the solution without stirring; (iv) closing the reaction vessel, and stirring the solution of step iii) in a nitrogen atmosphere. It further relates to a method for preparing the formulation.Type: GrantFiled: September 3, 2010Date of Patent: March 26, 2013Assignee: Neogen N.V.Inventor: Khaled Al Dandachi Atassi
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Patent number: 8178121Abstract: The present invention refers to ready-to-use highly stable paracetamol injectable solutions, prepared by mixing paracetamol, water, propylene glycol, and a citrate buffer. (pH 4.5 to 6.5), and by heating said solution under preset conditions. The resulting solution may be stored for an extended period of time within a wide range of temperatures, with no paracetamol precipitation and/or its chemical modification.Type: GrantFiled: October 15, 2002Date of Patent: May 15, 2012Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventor: Tho Nguyen-Xuan
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Patent number: 6992218Abstract: A method for obtaining aqueous formulations with easily oxidizable active principles, notably phenols, stable over a prolonged period, comprising subjecting them to extreme deoxygenation by bubbling with an inert gas and/or placing wider vaccum, protecting them against possible resorption of oxygen by keeping them under an inert gas atmosphere, by filling, under inert gas, into bottles previously cleared of air by insufflation with inert gas, then subjecting them, while stoppering, to low pressure as obtained in the bottle, of 65,000 Pa maximum, to obtain aqueous solutions having a residual oxygen concentration in the solution below 2 ppm, and preferably of the order of 1 ppm and even 0.5 ppm useful as injectable preparations having an oxygen concentration in the solution below 2 ppm.Type: GrantFiled: June 6, 2001Date of Patent: January 31, 2006Assignee: Pharmatop SCRInventors: Francois Dietlin, Daniele Fredj
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Patent number: 6586627Abstract: N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converted back into the aldehyde under mild conditions. The present invention relates to N-protected/N-substituted-beta-amino hydroxy sulfonates and their preparation and use.Type: GrantFiled: March 20, 2002Date of Patent: July 1, 2003Assignee: G. D. Searle & Co.Inventor: Joseph J. Wieczorek
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Patent number: 6028222Abstract: Novel stable paracetamol compositions for use in therapeutic chemistry and specifically galenic pharmacy are disclosed. The compositions contain a solution of paracetamol in an aqueous solvent combined with a buffer having a pH of 4 to 8, and a free radical capturing agent. A water-insoluble inert gas is carefully bubbled through the aqueous solvent to remove oxygen from the medium. Said compositions may also be combined with a centrally or peripherally acting analgesic agent, and are provided as injectable compositions for relieving pain.Type: GrantFiled: June 5, 1998Date of Patent: February 22, 2000Assignee: SCR PharmatopInventors: Francois Dietlin, Daniele Fredj
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Patent number: 6018078Abstract: N-nitrosohydroxylamine compounds exhibiting minimal or no degradation are disclosed. The N-nitrosohydroxylamines can be stabilized in the presence of a compound capable of removing water from the environment.Type: GrantFiled: June 23, 1999Date of Patent: January 25, 2000Assignee: First Chemical CorporationInventors: Darrell V. Harris, Paul J. Roman, Jr., Zhihong Wu, Earl G. Adams, Eric L. Williams
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Patent number: 5942151Abstract: A process for the production of polymethylene polyphenyl polyisocyanates is disclosed. The process comprises phosgenating the corresponding polyamines in solution in an inert organic solvent, removing excess phosgene, and stripping the solvent, the improvement wherein at least 0.00015 percent by weight of hydrazine or hydrazine derivative per 100 percent by weight of polyamine are added to the polyamines at any time prior to the stripping step.Type: GrantFiled: November 20, 1997Date of Patent: August 24, 1999Assignee: Bayer CorporationInventors: Rick L. Adkins, Clarence D. Blue
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Patent number: 5498791Abstract: A synergistic mixture of a carbonate and/or bicarbonate with a phosphonate, especially an organoamino methylene phosphonate or an N-oxide thereof, inhibits or reduces nitrosamine contamination during preparation, storage and/or heating of products which are susceptible to contamination with nitrosamine.Type: GrantFiled: January 20, 1995Date of Patent: March 12, 1996Assignee: Albright & Wilson, LimitedInventors: Michael Blezard, Glyn R. Jones, Moharam Ghadimi
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Patent number: 5442113Abstract: A synergistic mixture of a carbonate and/or bicarbonate with a phosphonate, especially an organoamino methylene phosphonate or an N-oxide thereof, inhibits or reduces nitrosamine contamination during preparation, storage and/or heating of products which are susceptible to contamination with nitrosamine.Type: GrantFiled: February 1, 1993Date of Patent: August 15, 1995Assignee: Albright & Wilson LimitedInventors: Michael Blezard, Glyn R. Jones, Moharam Ghadimi
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Patent number: 5349104Abstract: Without added stabilizers, aminobenzotrifluorides have low thermal and storage stability.The present invention relates to preparations of a stabilized amionbenzotrifluoride, composed essentially ofa) an aminobenzotrifluoride of the formula (I), ##STR1## in which R.sup.1 and R.sup.2, independently of each other, are hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, substituted or unsubstituted aryl, halogen, CF.sub.3, nitro, amino, methoxy, hydroxyl or NR.sup.3 R.sup.4, where R.sup.3 and R.sup.4, independently of each other, are hydrogen or C.sub.1 -C.sub.5 -alkyl radicals, and the NH.sub.2 group can be located in the 2-, 3- or 4-position in relation to the CF.sub.3 group, andb) at least one base.Type: GrantFiled: May 4, 1993Date of Patent: September 20, 1994Assignee: Hoechst AktiengesellschaftInventors: Gilbert Billeb, Gunther Semler
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Patent number: 5223644Abstract: Bicarbonates and/or carbonates are used in greater than catalytic amounts to inhibit the formation of nitrosamines during the preparation, storage and/or use of amine oxides.Type: GrantFiled: February 3, 1992Date of Patent: June 29, 1993Assignee: Albright & Wilson LimitedInventors: Michael Blezard, Glyn R. Jones