Phosphorus Containing Patents (Class 568/2)
  • Patent number: 10258976
    Abstract: Precatalysts of formula I and IV, and processes for the functionalization of SP2-carbons using the same are described herein. The precatalysts comprise a fluoroborate salt protected intramolecular frustrated lewis pair (FLP). The precatalysts are bench stable with improved stability towards moisture and/or air. The precatalysts can be used to generate in situ the corresponding FLP catalyst.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: April 16, 2019
    Assignee: UNIVERSITÉ LAVAL
    Inventors: Frédéric-Georges Fontaine, Marc-André Légaré, Étienne Rochette
  • Publication number: 20150065738
    Abstract: The present invention provides a phosphorous compound represented by general formula (1), and transition metal complexes containing such phosphorous compounds as ligands: wherein R1 to R7, A, B, Y, and Z have the same meanings as those defined in the specification.
    Type: Application
    Filed: August 22, 2014
    Publication date: March 5, 2015
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Naota YOKOYAMA, Yuji NAKAYAMA
  • Publication number: 20140350303
    Abstract: Catalysts for the reduction of CO2 are described herein. More specifically, catalysts of Formula I and Formula II: wherein LB is a Lewis base; LA is a Lewis acid; R1 is selected from hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; and R9 and R10 are independently selected from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, phenyl and substituted phenyl; are described. A process for the production of methanol from CO2 using such catalysts is also described.
    Type: Application
    Filed: April 23, 2014
    Publication date: November 27, 2014
    Applicant: UNIVERSITÉ LAVAL
    Inventors: Frédéric-Georges FONTAINE, Marc-André COURTEMANCHE
  • Patent number: 8846978
    Abstract: In some embodiments, the inventions described herein relate to a composition of matter comprising a molecule having the structure: wherein: independently at each occurrence, R1 is a halogen, a alkyl group, a heteroalkyl group, an aryl group, or a heteroaryl group; R2 comprises from 3 to 30 CH2— groups, n=0-5, m=0-5, q=1-3, and R2 comprises at least one ether linkage.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: September 30, 2014
    Assignees: Imperial Innovations Ltd., Georgia Tech Research Corporation
    Inventors: Peter Hotchkiss, Seth Marder, Anthony Giordano, Thomas D. Anthopoulos
  • Publication number: 20140142325
    Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.
    Type: Application
    Filed: July 10, 2012
    Publication date: May 22, 2014
    Applicant: Centre National de la Recherche Scientifique(CNRS)
    Inventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
  • Publication number: 20140114074
    Abstract: The invention relates to a process for the preparation of alkali-metal salts with dihydridodicyanoborate anions by reaction of alkali-metal tetrahydridoborates or trihydridocyanoborates with trialkylsilyl cyanide and further reaction thereof in metathesis reactions.
    Type: Application
    Filed: May 23, 2012
    Publication date: April 24, 2014
    Applicant: MERCK PATENT GmbH
    Inventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Eduard Bernhardt, Vera Bernhardt-Pitchougina, Helge Willner
  • Patent number: 8658832
    Abstract: The present invention relates to auxiliary ligands for luminescent metal complexes, particularly emitter complexes having such auxiliary ligands, and particularly light-emitting devices, and particularly organic light-emitting devices (OLED) having metal complexes, which have the auxiliary ligands according to the invention.
    Type: Grant
    Filed: July 3, 2008
    Date of Patent: February 25, 2014
    Assignee: Merck Patent GmbH
    Inventors: Hartmut Yersin, Rafal Czerwieniec, Uwe Monkowius
  • Patent number: 8642812
    Abstract: A compound having the formula (I) where each of R1, R2, R3 and R4 is independently C6-C18 aryl-, C5-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C4-C20 branched alkyl-, C16-C20 linear alkyl-, RO—, —NRR?, —PRR?, —SR, fluoro substituted forms thereof, and perfluoro forms thereof: and R5 is C6-C18 aryl-, C3-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C3-C20 branched alkyl-, C2-C30 linear alkyl-, fluoro substituted forms thereof, and perfluoro forms thereof; where R and R? are each independently C6-C18 aryl-, C5-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C4-C20 branched alkyl-, C2-C30 linear alkyl-, fluoro substituted forms thereof, and perfluoro forms thereof; A is N, P, S, or O with the proviso that when A is S, R2 is a nullity; and M is
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 4, 2014
    Assignee: Stephan Consulting Corporation
    Inventors: Douglas W. Stephan, Gregory C. Welch, Jenny S. J. McCahill
  • Patent number: 8604249
    Abstract: The invention relates to novel phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3 and Ar4 are as defined herein, and compositions including such phosphonium borate compounds in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex for use in carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and carbon-oxygen bond forming reactions.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: December 10, 2013
    Assignee: Hokko Chemical Industry Co., Ltd.
    Inventors: Shin Masaoka, Hideyuki Iwazaki
  • Publication number: 20130184461
    Abstract: Mechanosynthesis trajectories are described which are approximately coaxial, and are shown to be useful in a wide range of mechanosynthesis reactions regardless of the nature of the tip or the feedstock being transferred.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 18, 2013
    Inventors: Robert A. Freitas, JR., Ralph C. Merkle
  • Publication number: 20130178626
    Abstract: Processes are described for manufacturing atomically-precise tips using one or more tips in one or more mechanosynthetic reactions to create one or more atomically-precise tips. The processes may employ a variety of feedstock, binding any of a wide range of atoms to a workpiece to build the one or more atomically-precise tips. The processes result in atomically-precise mechanosynthesis tips with a wide variety of possible tip structures using a wide range of feedstock binding elements. Characteristics of such tips that may be used when designing new embodiments are also described.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 11, 2013
    Inventors: Robert A. Freitas, JR., Ralph C. Merkle
  • Publication number: 20130178627
    Abstract: Methods and systems for building three-dimensional workpieces are described using a plurality of mechanosynthetic reactions. These methods may employ engineered reliability in reactions and process conditions and may use simulated or otherwise vetted reaction sequences, to allow workpieces requiring many reactions to be built with acceptable reliability. These many reactions may be the repetition of one or a small number of reactions, or many diverse reactions, or a combination thereof.
    Type: Application
    Filed: February 28, 2013
    Publication date: July 11, 2013
    Inventors: Robert A. Freitas, JR., Ralph C. Merkle
  • Patent number: 8420755
    Abstract: The present invention relates to a novel metallocene compound, a catalyst composition including the compound and an olefin polymer prepared using the same. The metallocene compound and the catalyst composition can be used for preparing the olefin polymer with high copolymerization degree and high molecular weight. Particularly, the block copolymer with high heat resistance can be prepared by using the metallocene compound, and the olefin polymer with high melting point (Tm) can be obtained, even if co-monomer is used at an increased amount in preparation of olefin polymer.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: April 16, 2013
    Assignee: LG Chem, Ltd.
    Inventors: Young-Chul Won, Sung-Ho Chun, Dai-Seung Choi, Dong-Woo Yoo, Bun-Yeoul Lee
  • Publication number: 20130018207
    Abstract: A compound having the formula (I) where each of R1, R2, R3 and R4 is independently C6-C18 aryl-, C5-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl s?bstituent, C4-C20 branched alkyl-, C16-C20 linear alkyl-, RO—, —NRR?, —PRR?, —SR, fluoro substituted forms thereof, and perfluoro forms thereof: and R5 is C6-C18 aryl-, C5-C8cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C3-C20 branched alkyl-, C2-C30 linear alkyl-, fluoro substituted forms thereof, and perfluoro forms thereof; where R and R? are each independently C6-C18 aryl-, C5 -C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C4-C20 branched alkyl-, C2-C30 linear alkyl-, fluoro substituted forms thereof, and perfluoro forms thereof; A is N, P, S, or O with the proviso that when A is S, R2 is a nullity; and M is
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: STEPHAN CONSULTING CORPORATION
    Inventors: Douglas W. Stephan, Preston A. Chase, Gregory C. Welch
  • Patent number: 8349223
    Abstract: Boronated polyphosphinohydrazide fire retardants are provided having the basic structural unit: wherein, Y is O or S; R can be selected from H, alkyl (e.g., linear, branched, saturated, or unsaturated), aryl, heterocyclic, cycloaliphatic (e.g., saturated or unsaturated), or a metallocene (e.g., ferrocene, zirconocene or the like); and n can be selected from 1 to 500.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: January 8, 2013
    Assignee: The Boeing Company
    Inventors: Norman R. Byrd, Douglas G. Soden, Arthur Rojo
  • Publication number: 20120309982
    Abstract: The present invention relates to electrolyte formulations comprising at least one compound of formula (I) Ma+[B(Rf)(CN)x(F)y]a— (I) in which Ma+ is an inorganic or organic cation, Rf denotes straight-chain or branched perfluoroalkyl groups having 1 to 4 C atoms, C6F5, C6H5, partially fluorinated phenyl or phenyl which is monosubstituted or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms, a is 1 or 2, x is 1, 2 or 3, y is 0, 1 or 2 and x+y is 3 and their use in an electrochemical and/or optoelectronic device such as a photovoltaic cell, a capacitor, a light emitting device, an electrochromic or photo-electrochromic device, an electrochemical sensor and/or biosensor, preferably their use in a dye or quantum dot sensitized solar cell.
    Type: Application
    Filed: January 12, 2011
    Publication date: December 6, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Hiromi Shinohara, Kentaro Kawata, Hiroki Yoshizaki, Peer Kirsch, Nikolai (Mykola) Ignatyev, Michael Schulte, Jan Sprenger, Maik Finze, Walter Frank
  • Publication number: 20120309981
    Abstract: The invention relates to a process for the preparation of salts having perfluoroalkyltricyano- or perfluoroalkylcyanofluoroborate anions, ((per)fluoro)phenyltricyano- or ((per)fluoro)phenylcyanofluoroborate anions, phenyltricyanoborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms or phenylcyanofluoroborate anions which are mono- or disubstituted by perfluoroalkyl groups having 1 to 4 C atoms, by reaction of alkali metal trifluoroperfluoroalkylborate with trialkylsilyl cyanide and a subsequent salt-exchange reaction or by direct reaction of an organic trifluoroperfluoroalkyl borate with trialkylsilyl cyanide.
    Type: Application
    Filed: January 12, 2011
    Publication date: December 6, 2012
    Applicant: MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
    Inventors: Nikolai (Mykola) Ignatyev, Michael Schulte, Jan Sprenger, Maik Finze, Walter Frank
  • Patent number: 8277775
    Abstract: The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: October 2, 2012
    Assignee: The Research Foundation of the City University of New York
    Inventors: Robert Bittman, Zaiguo Li
  • Publication number: 20120197030
    Abstract: The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate.
    Type: Application
    Filed: December 21, 2009
    Publication date: August 2, 2012
    Applicant: Zhejiang University
    Inventors: Shengming Ma, Bo Lü, Chunling Fu
  • Patent number: 8124809
    Abstract: The invention relates to methods for carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and/or carbon-oxygen bond forming reactions using phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3, and Ar4 are as defined herein in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: February 28, 2012
    Assignee: Hokko Chemical Industry Co., Ltd.
    Inventors: Shin Masaoka, Hideyuki Iwazaki
  • Patent number: 8067642
    Abstract: The present invention provides P-chiral compounds of general formulae (II) and (III): in formula (II) at least one of R21, R25, R26 and R30 is independently selected from CM alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R21, R25, R26 and R30 are hydrogen; at least one of R22, R24, R27 and R29 are independently selected from C1-14 alkyl, CF3, C1-14 alkoxy, phenyl and benzyloxy and the remaining substituents selected, from R22, R24, R27 and R29 are hydrogen; and R23 and R28 are independently selected from hydrogen, CM alkyl, CF3, C1-14 alkoxy, phenyl and benzyloxy; in formula (III) at least one of R21, R25, R26 and R30 is independently selected from phenyl and benzyloxy and the remaining substituents selected from R21, R25, R?26 and R30 are hydrogen; and R22, R?23 R24, R27, R28 and R29 are independently selected from hydrogen, C1-14 alkyl, CF3, C1-14 alkoxy, phenyl and benzyloxy.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: November 29, 2011
    Assignee: Celtice Catalysts Limited, Nova UCD
    Inventors: Graham R. Cumming, Declan Gilheany, Gary King, Matthias Voegler, Vladimir Larichev
  • Patent number: 8053604
    Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: November 8, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Mitsutaka Goto, Mitsuhisa Yamano
  • Publication number: 20110166389
    Abstract: The invention relates to novel phosphonium borate compounds represented by the Formula: (R1)(R2)(R3)PH.BAr4, wherein R1, R2, R3 and Ar4 are as defined herein, and compositions including such phosphonium borate compounds in combination with a transition metal, transition metal salt, transition metal oxide or transition metal complex for use in carbon-carbon bond forming reactions, carbon-nitrogen bond forming reactions and carbon-oxygen bond forming reactions.
    Type: Application
    Filed: November 16, 2010
    Publication date: July 7, 2011
    Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.
    Inventors: Shin MASAOKA, Hideyuki IWAZAKI
  • Publication number: 20110130532
    Abstract: The present invention relates to a novel metallocene compound, a catalyst composition including the compound and an olefin polymer prepared using the same. The metallocene compound and the catalyst composition can be used for preparing the olefin polymer with high copolymerization degree and high molecular weight. Particularly, the block copolymer with high heat resistance can be prepared by using the metallocene compound, and the olefin polymer with high melting point (Tm) can be obtained, even if co-monomer is used at an increased amount in preparation of olefin polymer.
    Type: Application
    Filed: August 17, 2010
    Publication date: June 2, 2011
    Applicant: LG CHEM, LTD.
    Inventors: Young-Chul WON, Sung-Ho CHUN, Dai-Seung CHOI, Dong-Woo YOO, Bun-Yeoul LEE
  • Patent number: 7932239
    Abstract: Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing neuronal cell death-related diseases or conditions in a human or a non-human animal.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: April 26, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Leonard A. Levin
  • Publication number: 20110082300
    Abstract: The present invention relates to FTY720 analogs bearing a boron dipyrromethene difluoro (BODIPY) fluorophore in the alkyl side chain and methods of preparation. The compounds of the present invention can be used in fluorescence spectroscopy and fluorescence microscopy and in chromatography using fluorescence detection.
    Type: Application
    Filed: August 15, 2008
    Publication date: April 7, 2011
    Applicant: Research Foundation of the city University of New York
    Inventors: Robert Bittman, Zaiguo Li
  • Patent number: 7862984
    Abstract: A radiation-sensitive composition includes a free-radically polymerizable component, an initiator composition capable of generating free radicals sufficient to initiate polymerization upon exposure to imaging radiation, an infrared radiation absorbing compound, and a polymeric binder. The initiator composition includes a unique polyonium borate comprising a polyvalent onium cation with multiple onium moieties and sufficient organic borate counterions to provide a net neutral charge. The radiation-sensitive composition can be used to prepare a negative-working imageable element that is sensitive to suitable imaging infrared radiation, can be imaged at relatively low energy, and can be developed either on-press or off-press.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: January 4, 2011
    Assignee: Eastman Kodak Company
    Inventors: Koji Hayashi, Jianbing Huang
  • Patent number: 7847126
    Abstract: The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.
    Type: Grant
    Filed: June 5, 2007
    Date of Patent: December 7, 2010
    Assignee: LANXESS Deutschland GmbH
    Inventors: Florian Rampf, Hans-Christian Militzer
  • Publication number: 20100292084
    Abstract: A novel process of preparing tridentate ligands containing one or more of a diarylphosphine and/or dialkylphosphine electron donating groups are disclosed. Use of this process for preparing a combinatorial library of such tridentate ligands and of organometallic complexes containing same is also disclosed. Further disclosed are novel diarylphosphine-containing and dialkylphosphine-containing compounds that can serve as tridentate ligands (e.g., pincer ligands), combinatorial libraries of such tridentate ligands, organometallic complexes containing these ligands (e.g., pincer complexes), and combinatorial libraries of such complexes. Methods utilizing these libraries for screening for candidate organometallic catalysts are also disclosed. Novel precursor molecules useful for preparing the tridentate ligands and processes of preparing same are also disclosed.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 18, 2010
    Applicant: Technion Research & Development Foundation Ltd.
    Inventors: Mark GANDELMAN, Elaine Melissa Schuster, Gennady Nisnevich
  • Publication number: 20100168456
    Abstract: The present invention provides P-chiral compounds of general formulae (II) and (III): in formula (II) at least one of R21, R25, R26 and R30 is independently selected from CM alkyl, CF3, C1-4 alkoxy, phenyl and benzyloxy and the remaining substituents selected from R21, R25, R26 and R30 are hydrogen; at least one of R22, R24, R27 and R29 are independently selected from C1-14 alkyl, CF3, C1-14 alkoxy, phenyl and benzyloxy and the remaining substituents selected, from R22, R24, R27 and R29 are hydrogen; and R23 and R28 are independently selected from hydrogen, CM alkyl, CF3, C1-14 alkoxy, phenyl and benzyloxy; in formula (III) at least one of R21, R25, R26 and R30 is independently selected from phenyl and benzyloxy and the remaining substituents selected from R21, R25, R—26 and R30 are hydrogen; and R22, R—23 R24, R27, R28 and R29 are independently selected from hydrogen, C1-14 alkyl, CF3, C1-14 alkoxy, phenyl and benzyloxy.
    Type: Application
    Filed: March 28, 2008
    Publication date: July 1, 2010
    Applicant: Celtic Catalysts Limited
    Inventors: Declan Gilheany, Graham R. Cumming, Gary King, Matthias Voegler, Vladimir Larichev
  • Patent number: 7723548
    Abstract: The present invention aims to provide a bis(phosphine) boronium salt to be used as a building block or the like for producing a diphosphine compound effective mainly for various kinds of transition metal-catalyzed reactions and further to provide a preferable production method of the bis(phosphine) boronium salt and a bis(phosphine) boronium salt to be produced by the production method. The present invention provides a bis(phosphine) boronium salt having the structure defined by the following formula (1).
    Type: Grant
    Filed: January 30, 2007
    Date of Patent: May 25, 2010
    Assignee: Japan Science and Technology Agency
    Inventors: Kentaro Yamaguchi, Hiroshi Danjo, Toru Koizumi, Tsuneo Imamoto
  • Publication number: 20100125153
    Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 20, 2010
    Inventors: Mitsutaka Goto, Mitsuhisa Yamano
  • Publication number: 20100111867
    Abstract: The invention describes compounds for use in BCNT. These compounds comprise a carborane group coupled to a phosphorus containing group. The compounds may comprise a carborane group coupled to a phosphonium group.
    Type: Application
    Filed: February 15, 2008
    Publication date: May 6, 2010
    Applicant: THE UNIVERSITY OF SYDNEY
    Inventors: Louis M. Rendina, Joseph A. Ioppolo
  • Publication number: 20100099875
    Abstract: The invention relates to novel organo phosphorus P-chiral optically active compounds of formula (I) having a hydroxyl, mercapto, amino, carboxyl, sulfonyl group on aryl near a phosphorus atom, to the preparation and the use thereof in then asymmetrical catalysis of unsaturated compounds. Novel acylphosphine optically pure ligands embodied in the form of transition metal complexes exhibit an increased activity and enantloselectivity, in particular in asymmetrical hydrogenation, in comparison with the same type Uganda such as DiPAMP.
    Type: Application
    Filed: June 20, 2006
    Publication date: April 22, 2010
    Applicants: PHOSPHOENIX SARL, NATIONAL INSTITUTE OF CHEMISTRY
    Inventors: Michel Stephan, Barbara Mohar
  • Patent number: 7678942
    Abstract: A production method of a compound represented by the formula wherein R1a, R1b, R1c, R1d, R1e, R1f, R2a, R2b, R2c, R2d, R2e and R2f are the same or different and each is a hydrogen atom and the like, and R3, R4, R5, R6, R7, R8, R9 and R10 are the same or different and each is a hydrogen atom and the like, or a salt thereof, which comprises reacting a compound represented by the formula wherein X is a leaving group and other symbols are as defined above, or a salt thereof, with a phosphine-borane complex represented by the formula wherein the symbols are as defined above, or a salt thereof, in a solvent in the presence of an amine and a nickel catalyst, is provided.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: March 16, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Mitsutaka Goto, Mitsuhisa Yamano
  • Publication number: 20100048949
    Abstract: A compound having the formula (I) where each of R1, R2, R3 and R4 is independently C6-C18 aryl-, C5-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C4-C20 branched alkyl-, C16-C20 linear alkyl-, RO—, —NRR?, —PRR?, —SR, fluoro substituted forms thereof, and perfluoro forms thereof: and R5 is C6-C18 aryl-, C5-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C3-C20 branched alkyl-, C2-C30 linear alkyl-, fluoro substituted forms thereof, and perfluoro forms thereof; where R and R? are each independently C6-C18aryl-, C5-C8 cycloalkyl-, C6-C18 aryl having at least one C1-C20 alkyl substituent, C5-C8 cycloalkyl having at least one C1-C20 alkyl substituent, C4-C20 branched alkyl-, C2-C30 linear alkyl-, fluoro substituted forms thereof, and perfluoro forms thereof; A is N, P, S, or O with the proviso that when A is S, R2 is a nullify; and M is
    Type: Application
    Filed: November 14, 2007
    Publication date: February 25, 2010
    Applicant: STEPHAN CONSULTING CORPORATION
    Inventors: Douglas W. Stephan, Preston A. Chase, Gregory C. Welch
  • Publication number: 20090305877
    Abstract: The invention relates to a phosphonium borate compound represented by Formula (I) (hereinafter, the compound (I)). The invention has objects of providing (A) a novel process whereby the compound is produced safely on an industrial scale, by simple reaction operations and in a high yield; (B) a novel compound that is easily handled; and (C) novel use as catalyst. Formula (I): (R1)(R2)(R3)PH.BAr4??(I) wherein R1, R2, R3 and Ar are as defined in the specification. The process (A) includes reacting a phosphine with a) HCl or b) H2SO4 to produce a) a hydrochloride or b) a sulfate; and reacting the salt with a tetraarylborate compound. The compound (B) has for example a secondary or tertiary alkyl group as R1 and is easily handled in air without special attention.
    Type: Application
    Filed: April 8, 2009
    Publication date: December 10, 2009
    Applicant: HOKKO CHEMICAL INDUSTRY CO., LTD.
    Inventors: Shin Masaoka, Hideyuki Iwazaki
  • Publication number: 20090292135
    Abstract: The invention relates to chemical genera of organometal benzenephosphonates useful in cross-coupling organic synthesis, having general formula: where R is selected from boron, zinc, tin and silicon residues.
    Type: Application
    Filed: May 9, 2006
    Publication date: November 26, 2009
    Applicant: Ironwood Pharmaceuticals, Inc.
    Inventors: Timothy C. Barden, Peter Lee, Eduardo J. Martinez, Wayne C. Schairer, John J. Talley, JingJing Yang
  • Patent number: 7541498
    Abstract: A process for the production of phosphine-borane complexes represented by the general formula: or salts thereof: [wherein R1, R2 and R3 are each independently a hydrogen atom, a halogen atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted aryl group, or an optionally substituted heterocyclic group (with the proviso that R1 and R2 together with the adjacent phosphorus atom may form a 4- to 6-membered ring)], characterized by converting a compound represented by the general formula: in a solvent in the presence of a borane reagent: [wherein each symbol is as defined above].
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: June 2, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Mitsuhisa Yamano, Mitsutaka Goto, Masatoshi Yamada
  • Patent number: 7514563
    Abstract: A process for producing cyano substituted arene boranes is described. The compounds are useful intermediates to pharmaceutical compounds using the cyano group as a reactant.
    Type: Grant
    Filed: June 8, 2006
    Date of Patent: April 7, 2009
    Assignee: Board of Trustees of Michigan State University
    Inventors: Milton R. Smith, III, Robert E. Maleczka, Ghayoor A. Chotana
  • Publication number: 20090062567
    Abstract: The present invention aims to provide a bis(phosphine) boronium salt to be used as a building block or the like for producing a diphosphine compound effective mainly for various kinds of transition metal-catalyzed reactions and further to provide a preferable production method of the bis(phosphine) boronium salt and a bis(phosphine) boronium salt to be produced by the production method. The present invention provides a bis(phosphine) boronium salt having the structure defined by the following formula (1).
    Type: Application
    Filed: January 30, 2007
    Publication date: March 5, 2009
    Applicants: Japan Science and Technology Agency, National University Corporation Chiba University
    Inventors: Kentaro Yamaguchi, Hiroshi Danjo, Toru Koizumi, Tsuneo Imamoto
  • Publication number: 20080241754
    Abstract: A radiation-sensitive composition includes a free-radically polymerizable component, an initiator composition capable of generating free radicals sufficient to initiate polymerization upon exposure to imaging radiation, an infrared radiation absorbing compound, and a polymeric binder. The initiator composition includes a unique polyonium borate comprising a polyvalent onium cation with multiple onium moieties and sufficient organic borate counterions to provide a net neutral charge. The radiation-sensitive composition can be used to prepare a negative-working imageable element that is sensitive to suitable imaging infrared radiation, can be imaged at relatively low energy, and can be developed either on-press or off-press.
    Type: Application
    Filed: March 28, 2007
    Publication date: October 2, 2008
    Inventors: Koji Hayashi, Jianbing Huang
  • Publication number: 20080242534
    Abstract: A compound represented by the following general formula (I): [wherein R1 represents hydrogen atom, or an alkyl group, R2 represents a hydroxyalkyl group, or a triarylmethyloxyalkyl group, or R1 and R2 combine together to represent —C(R3)(R4)— (R3 and R4 represent hydrogen atom, an alkyl group, or hydroxyl group, or R3 and R4 may combine together to represent oxo group), or —C(R5)(R6)—O—C(R7)(R8)— (R5 to R8 represent hydrogen atom, an alkyl group, or hydroxyl group, or R5 and R6 may combine together to represent oxo group, and R7 and R8 may combine together to represent oxo group); Ar1 to Ar4 independently represent an aryl group (the aryl group may have 1 to 5 of the same or different substituents), *1 to *4 indicate asymmetric carbons, and configurations are cis between *1 and *2, cis between *3 and *4, and trans between *2 and *3]. An optically active phosphine ligand which can be easily synthesized and gives a transition metal complex showing superior asymmetric catalyst activity is provided.
    Type: Application
    Filed: March 25, 2008
    Publication date: October 2, 2008
    Applicant: DAIICHI FINE CHEMICAL CO., LTD.
    Inventors: Michimasa WATANABE, Yuhki TAKEUCHI, Takahiro ISOBE, Tadashi TAKEUCHI
  • Publication number: 20080214829
    Abstract: The invention relates to salts having alkoxytris(fluoroalkyl)borate anions which on the one hand are used for the synthesis of ionic liquids, but on the other hand can be employed per se as ionic liquid, and to processes for the preparation thereof.
    Type: Application
    Filed: July 9, 2005
    Publication date: September 4, 2008
    Inventors: Nikola (Mykola) Ignatyev, Urs Welz-Biermann, Maik Finze, Eduard Bernhardt, Helge Willner
  • Patent number: 7317129
    Abstract: The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly, for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
    Type: Grant
    Filed: September 19, 2005
    Date of Patent: January 8, 2008
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Yi He, Matthew B. Soellner, Ronald J. Hinklin
  • Patent number: 7214830
    Abstract: A description is given of processes for the preparation of mono- and bisacylphosphines and of mono- and bisacylphosphine oxides and mono- and bisacylphosphine sulfides, which comprises first reacting organic P-monohalogenophosphines or P,P-dihalogenophosphines, or mixtures thereof, with an alkali metal or magnesium in combination with lithium, where appropriate in the presence of a catalyst, and then carrying out the reaction with acid halides and, in the case of the process for the preparation of oxides, carrying out an oxidation step and, in the case of the preparation of sulfides, reacting the phosphines so obtained with sulfur. It is characteristic, inter alia, that the processes are carried out without isolation of the intermediates.
    Type: Grant
    Filed: February 6, 2006
    Date of Patent: May 8, 2007
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: David George Leppard, Eugen Eichenberger, René Kaeser, Gebhard Hug, Urs Schwendimann
  • Patent number: 7115539
    Abstract: A metal compound obtained by a process comprising the step of contacting, in a specific ratio, a compound represented by the formula M1L1r, a compound represented by the formula R1s?1TH, and a compound represented by the formula R24?nJ(OH)n; a catalyst component for addition polymerization comprising the metal compound; a catalyst for addition polymerization using the catalyst component; and a process for producing an addition polymer using the catalyst.
    Type: Grant
    Filed: January 9, 2004
    Date of Patent: October 3, 2006
    Assignee: Sumitomo Chemical Company Limited
    Inventors: Kazuo Takaoki, Hideki Oshima, Makoto Satoh
  • Patent number: 6974884
    Abstract: The present invention provides improved methods for synthesis of phosphinothiol reagents, as well as novel protected reagents, for use in formation of amide bonds, and particularly for peptide ligation. The invention provides phosphine-borane complexes useful as reagents in the formation of amide bonds, particularly for the formation of an amide bond between any two of an amino acid, a peptide, or a protein.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: December 13, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ronald T. Raines, Laura L. Kiessling, Bradley L. Nilsson, Yi He, Matthew B. Soellner, Ronald J. Hinklin
  • Patent number: 6809209
    Abstract: The invention addresses an composition of matter comprising a cation [Ct]+ and an anion [A]−, the anion comprises a core Group-13 element bound to partially or completely fluorinated fluoroaryl ligands, at least one of the fluoroaryl ligands is substituted with a Group-15 element that has been rendered essentially inert for subsequent chemical reaction through its unbonded electron pair by substituting an electron-withdrawing group on it. [Ct]+ may be selected from anilinium and ammonium cations, trityl carbenium cations, Group-11 metal cations, silylium cations, the cations of the hydrated salts of Group-1 or -2 metals, and derivatives of the foregoing anilinium, ammonium, trityl carbenium, and silylium cations containing C1-C20 hydrocarbyl, hydrocarbylsilyl, or hydrocarbylamine substituents for one or more hydrogen atoms of said cations.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: October 26, 2004
    Assignee: ExxonMobil Chemical Patents Inc.
    Inventor: George Rodriguez
  • Publication number: 20040053139
    Abstract: The object of the present invention is to supply organic borates highly soluble even in a solvent of a low dielectric constant; nonaqueous electrolytes made from these organic borates and excellent in characteristics; lithium secondary batteries with improved high-temperature storage characteristics; electric appliances that can be free of protection circuits, and; various applications of the electric appliances.
    Type: Application
    Filed: August 15, 2003
    Publication date: March 18, 2004
    Applicants: Hitachi, Ltd., Kanto Kagaku Kabushiki Kaisha
    Inventors: Juichi Arai, Hideaki Katayama, Mitsuru Kobayashi, Hiroyuki Yamaguchi, Hideki Takahashi, Masaru Kato