Halogen Containing Reactant Patents (Class 568/316)
  • Patent number: 9862937
    Abstract: The invention relates to a process for the preparation of a compound of formula I (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to the compound of formula I.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: January 9, 2018
    Assignee: Syngenta Participations AG
    Inventor: Denis Gribkov
  • Patent number: 9765006
    Abstract: The present invention refers to a process for producing 5-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl]-3-[4-(2-hydroxy-2-methyl)-1-oxo-prop-1-yl-phenyl]-2,3-dihydro-1,1,3-trimethyl-1H-indene (dimer isomer 5) that comprises the acylation of cumene in the 4-position with an isobutyryl halide, followed by benzylic halogenation and dimerization (cyclization) of the resulting product.
    Type: Grant
    Filed: June 8, 2015
    Date of Patent: September 19, 2017
    Assignee: IGM RESINS ITALIA S.R.L.
    Inventors: Gabriele Norcini, Angelo Casiraghi, Enzo Meneguzzo, Giovanni Floridi, Giuseppe Li Bassi
  • Patent number: 9309165
    Abstract: The present invention discloses the compound 6-chloro-3-(phenyl-d5)-inden-1-one (I) and routes of synthesis to obtain (I). In a further aspect the present invention discloses the use of (I) for the synthesis of (S)-6-chloro-3-(phenyl-d5)-indan-1-one.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: April 12, 2016
    Assignee: H. Lundbeck A/S
    Inventors: Mikkel Fog Jacobsen, Sebastian Brandes
  • Patent number: 9096560
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Grant
    Filed: July 1, 2009
    Date of Patent: August 4, 2015
    Assignee: Syngenta Limited
    Inventors: Stephane André Marie Jeanmart, Russell Colin Viner, John Benjamin Taylor, William Guy Whittingham, Jeffrey Steven Wailes, Sarah Margaret Targett, Christopher John Mathews, Mangala Govenkar, Matthew Robert Cordingley, Claire Janet Russell, Melloney Tyte
  • Publication number: 20150119576
    Abstract: There is provided a novel intermediate for producing pesticides. A method for producing the compound of Formula (3) comprises reacting an aromatic ketone compound of Formula (4) and a substituted acetophenone compound of Formula (5) as starting raw materials in an organic solvent or water in the presence or absence of an additive in the presence of a base in a suspended state. A method may comprise dehydrating the compound of Formula (3). A method for producing compound (2) in one step comprises reacting compound (4) and compound (5) to obtain compound (3). Further, a method for producing an isoxazoline compound of Formula (1) comprises reacting compound (2) and a hydroxylamine in an aliphatic or an aromatic hydrocarbon solvent which is optionally substituted by a halogen atom by adding an additive selected from a phase-transfer catalyst, a C1-C6 alcohol and an aprotic polar solvent in the presence of a base and water.
    Type: Application
    Filed: December 29, 2014
    Publication date: April 30, 2015
    Inventors: Manabu YAOSAKA, Tomohisa UTSUNOMIYA, Yuji MORIYAMA, Tomohiro MATSUMOTO, Kazutaka MATOBA
  • Patent number: 8927779
    Abstract: The present invention relates to a method for the hydroxylation of halogen aryl compounds carried out at a temperature lower than 200° C. in the presence of a catalytic system including a copper-based catalyst and a ligand L according to reaction scheme Formula (A), in which: R is selected from the groups having an acceptor inductive effect and the groups having a donor mesomer effect; M is selected from alkaline or alkaline-earth cations; X is a halogen atom; r is between 0 and 5; and the ligand L is selected from compounds having formula I.
    Type: Grant
    Filed: June 8, 2010
    Date of Patent: January 6, 2015
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Marc Taillefer, Anis Tlilli, Florian Monnier, Ning Xia
  • Patent number: 8877931
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: November 4, 2014
    Assignee: Gilead Sciences, Inc.
    Inventors: Dominika Pcion, Carrie Tomasi, Mark Charles Whitcomb, Eric D. Dowdy, Wenyi Fu, Patricia MacLeod
  • Patent number: 8828908
    Abstract: Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: September 9, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, Matthew Brian Hotson, Alan John Dowling, James Nicholas Scutt, Mangala Govenkar, Lee Challinor
  • Publication number: 20140235867
    Abstract: The present invention relates to a specific thiazolium salt used for producing an ?-hydroxy ketone compound, and a method for producing an ?-hydroxy ketone compound by carrying out a coupling reaction of an aldehyde compound in the presence of a base compound and the specific thiazolium salt.
    Type: Application
    Filed: August 27, 2012
    Publication date: August 21, 2014
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Koji Hagiya, Akio Tanaka, Toshihiro Hodai
  • Patent number: 8742175
    Abstract: The present invention discloses novel aromatic ketone compounds with functional substitution groups at para- or meta positions which can be used as photo-initiators or effective components of photo-initiator mixtures for the photopolymerizations of ethylenically unsaturated systems. The preparation of these compounds is also disclosed.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: June 3, 2014
    Assignee: Shenzhen UV-Chemtech Co., Ltd.
    Inventors: Yongbo Zhang, Yanchao Wang, Yapeng Wang, Huaihai Song, Zhigang Wang
  • Publication number: 20140058101
    Abstract: The invention is directed to a phosphine compound represented by general formula (1) wherein R? and R? independently are selected from alkyl, cycloalkyl and 2-furyl radicals, or R? and R? are joined together to form with the phosphorous atom a carbon-phosphorous monocycle comprising at least 3 carbon atoms or a carbon-phosphorous bicycle; the alkyl radicals, cycloalkyl radicals, and carbon-phosphorous monocycle being unsubstituted or substituted by at least one radical selected from the group of alkyl, cycloalkyl, aryl, alkoxy, and aryloxy radicals; Cps is a partially substituted or completely substituted cyclopentadien-1-yl group, including substitutions resulting in a fused ring system, and wherein a substitution at the 1-position of the cyclopentadien-1-yl group is mandatory when the cyclopentadien-1-yl group is not part of a fused ring system or is part of an indenyl group. Also claimed is the use of these phosphines as ligands in catalytic reactions and the preparation of these phosphines.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 27, 2014
    Applicant: Evonik Degussa GmbH
    Inventors: Herbert Plenio, Christoph Fleckenstein, Renat Kadyrov, Juan Almena, Axel Monsees, Thomas Riermeier
  • Publication number: 20140039194
    Abstract: The invention provides synthetic processes and synthetic intermediates that can be used to prepare 4-oxoquinolone compounds having useful integrase inhibiting properties.
    Type: Application
    Filed: August 1, 2013
    Publication date: February 6, 2014
    Applicant: Gilead Sciences, Inc.
    Inventors: Dominika PCION, Carrie TOMASI, Mark Charles WHITCOMB, Eric D. DOWDY, Wenyi FU, Patricia MACLEOD
  • Publication number: 20140012027
    Abstract: A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicants: Taiyo Nippon Sanso Corporation, Kyoto University
    Inventors: Junichi YOSHIDA, Aiichiro NAGAKI
  • Patent number: 8598387
    Abstract: Disclosed herein is novel process for preparation of atovaquone, which process includes reacting 1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: December 3, 2013
    Assignee: Glaxo Group Limited
    Inventors: Andrew Neil Dwyer, Andrew Gordon, Michael Urquhart
  • Patent number: 8546618
    Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water.
    Type: Grant
    Filed: April 8, 2009
    Date of Patent: October 1, 2013
    Assignee: E.I. du Pont de Nemours and Company
    Inventor: Gary David Annis
  • Patent number: 8541624
    Abstract: Disclosed are: a novel palladium catalyst which does not undergo leakage, can be recycled, does not require the use of any phosphorus-containing ligand, and has a high catalytic activity; and a process for producing a novel bisaryl compound using the palladium catalyst. In the production of a bisaryl compound by reacting an aromatic halide with an aromatic boronic acid in the presence of a palladium catalyst and a base, the palladium catalyst comprises a dendrimer containing a silica particle as a core and a palladium compound dissolved in an ionic liquid and supported on the dendrimer.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: September 24, 2013
    Assignee: Niigata University
    Inventors: Hisahiro Hagiwara, Norio Tsubokawa
  • Publication number: 20130225815
    Abstract: A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.
    Type: Application
    Filed: February 19, 2013
    Publication date: August 29, 2013
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: John F. Hartwig, Hiroyuki Morimoto, Patrick Fier
  • Publication number: 20130217877
    Abstract: The present invention discloses novel aromatic ketone compounds with functional substiution groups at para- or meta positions which can be used as photo-initiators or effective components of photo-initiator mixtures for the photopolymerizations of ethylenically unsaturated systems. The preparation of these compounds is also disclosed.
    Type: Application
    Filed: November 4, 2011
    Publication date: August 22, 2013
    Applicant: SHENZHEN UV-CHEMTECH CO., LTD
    Inventors: Yongbo Zhang, Yanchao Wang, Yapeng Wang, Huaihai Song, Zhigang Wang
  • Patent number: 8513374
    Abstract: This invention describes the use of resveratrol and curcumin, representatives of naturally occurring polyphenols, in their native form, after hydrogenation, and as their respective allyl derivatives, individually, in combination with themselves and other commercial monomers, to make representative varieties of polymers, e.g., polycarbonates (PC), polyurethanes (PU), co-polymers and biodegradable polymers.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: August 20, 2013
    Inventor: Falguni Dasgupta
  • Publication number: 20130158219
    Abstract: The invention relates to compounds, in particular phosphinic ligands of metal complexes, as well as to metal complexes including said ligands and to supported catalysts including said metal complexes or said compounds. The invention also relates to methods for synthesizing said compounds, to complexes, and to supported catalysts, as well as to intermediate products used in said synthesis methods. The invention further relates to the uses of said compounds. The compounds of the invention are ferrocene compounds which have been functionalized so as to be capable of being heterogenized. The invention can be used in particular in the field of heterogeneous catalysis.
    Type: Application
    Filed: June 24, 2011
    Publication date: June 20, 2013
    Applicants: Universite de Bourgogne, Centre National De La Recherche Scientifique
    Inventors: Jean-Cyrille Hierso, Matthieu Beauperin, Philippe Meunier
  • Publication number: 20130096348
    Abstract: The present invention proposes a chiral diene ligand, a fabrication method thereof and applications thereof. The chiral diene ligand is a bicyclo[2.2.1] diene ligand having structural specificity and high stability, which favors the bicyclo[2.2.1] diene ligand to take part in asymmetric transformations, particularly an asymmetric addition reaction involving a metal catalyst in a basic environment. Most of the products of the reactions implemented by the chiral diene ligands of the present invention have superior optical activity. The method of the present invention comprises a first oxidation step, a saponification step, a second oxidation step, a deprotonation step, and a cross-coupling step. The chiral diene ligand of the present invention is very suitable to be used in the fabrication or synthesis of various chemicals and medical products.
    Type: Application
    Filed: September 10, 2012
    Publication date: April 18, 2013
    Inventors: Hsyueh-Liang WU, Chun-Chih Chen, Chia-Chen Liu, Wei-Ting Wei, Jo-Hsuan Fang
  • Publication number: 20120308738
    Abstract: Photolabile scent storage substance that are capable of photoinduced release of cyclic compounds have at least one cyclic double bond. These scent storage substances are special ketones, and enable greatly improved stability of the scent impression, in particular with a fresh character, in typical applications, for example in textile laundering, room scenting, and in the cosmetic sector. More economical utilization of the stored scents can thereby be ensured. Also described are corresponding washing or cleaning agents, scenting methods, and methods for manufacturing the special ketones.
    Type: Application
    Filed: August 15, 2012
    Publication date: December 6, 2012
    Applicant: Henkel AG & Co. KGaA
    Inventors: Thomas Gerke, Christian Kropf, Ursula Huchel, Axel Griesbeck, Olga Hinze
  • Publication number: 20120245348
    Abstract: Disclosed herein are phosphine compounds represented by the general formula (4): and corresponding phosphonium salts represented by the general formula (4a): Also disclosed are processes for the preparation of these phosphines and phosphonium salts as well as their use as ligands in catalytic reactions.
    Type: Application
    Filed: April 2, 2012
    Publication date: September 27, 2012
    Inventors: Herbert PLENIO, Christoph FLECKENSTEIN, Renat KADYROV, Juan ALMENA, Axel MONSEES, Thomas RIERMEIER
  • Publication number: 20120238549
    Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.
    Type: Application
    Filed: March 15, 2012
    Publication date: September 20, 2012
    Applicant: ABBOTT LABORATORIES
    Inventors: Kevin P. Cusack, Thomas D. Gordon, David C. Ihle, Martin E. Hayes, Eric C. Breinlinger, Anna M. Ericsson, Bin Li, Lei Wang, Gloria Y. Martinez, Andrew Burchat, Adrian D. Hobson, Kelly D. Mullen, Michael Friedman, Michael J. Morytko
  • Publication number: 20120238699
    Abstract: A star polymer is produced by converting a central compound having at least three functional groups X, an arylene compound having two functional groups Y, and a terminal group compound having a functional group Z, the functional groups X of the central compound each reacting with a functional group Y of the arylene compound, forming a covalent bond, and the functional group Z of the terminal group compound reacting with a functional group Y of the arylene compound, forming a covalent bond, the terminal group compound being used in a stoichiometric quantity that corresponds essentially to the stoichiometric quantity of the functional groups X of the central compound, and to a method for producing star polymers, a polymer mixture including star polymers, and to the use of star polymers.
    Type: Application
    Filed: July 23, 2010
    Publication date: September 20, 2012
    Inventors: Hans-Georg Herz, Gerhard Maier, Philipp Koelle
  • Publication number: 20120232310
    Abstract: Disclosed are: a novel palladium catalyst which does not undergo leakage, can be recycled, does not require the use of any phosphorus-containing ligand, and has a high catalytic activity; and a process for producing a novel bisaryl compound using the palladium catalyst. In the production of a bisaryl compound by reacting an aromatic halide with an aromatic boronic acid in the presence of a palladium catalyst and a base, the palladium catalyst comprises a dendrimer containing a silica particle as a core and a palladium compound dissolved in an ionic liquid and supported on the dendrimer.
    Type: Application
    Filed: November 11, 2010
    Publication date: September 13, 2012
    Applicant: Niigata University
    Inventors: Hisahiro Hagiwara, Norio Tsubokawa
  • Publication number: 20120190545
    Abstract: Compounds of formula (I) wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: July 17, 2009
    Publication date: July 26, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, James Nicholas Scutt
  • Publication number: 20120184682
    Abstract: This invention describes the use of resveratrol and curcumin, representatives of naturally occurring polyphenols, in their native form, after hydrogenation, and as their respective allyl derivatives, individually, in combination with themselves and other commercial monomers, to make representative varieties of polymers, e.g., polycarbonates (PC), polyurethanes (PU), co-polymers and biodegradable polymers.
    Type: Application
    Filed: September 30, 2010
    Publication date: July 19, 2012
    Applicant: INNOVOTECH, LLC
    Inventor: Falguni Dasgupta
  • Publication number: 20120157704
    Abstract: The present invention relates to a method for the hydroxylation of halogen aryl compounds carried out at a temperature lower than 200° C. in the presence of a catalytic system including a copper-based catalyst and a ligand L according to reaction scheme Formula (A), in which: R is selected from the groups having an acceptor inductive effect and the groups having a donor mesomer effect; M is selected from alkaline or alkaline-earth cations; X is a halogen atom; r is between 0 and 5; and the ligand L is selected from compounds having formula I.
    Type: Application
    Filed: June 8, 2010
    Publication date: June 21, 2012
    Inventors: Marc Taillefer, Anis Tlilli, Florian Monnier, Ning Xia
  • Publication number: 20120142915
    Abstract: This disclosure concerns a protected cyclopropylboronic acid comprising a substituted cyclopropyl group and a boronic ester group having a protecting group. The protecting group is an N-methyliminodiacetic acid (MIDA) group or MIDA-based group.
    Type: Application
    Filed: December 1, 2011
    Publication date: June 7, 2012
    Inventors: Matthew Duncton, Rajinder Singh
  • Publication number: 20110178302
    Abstract: Iodylbenzene derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are used as precursors in aromatic nucleophilic substitution reactions. The iodyl group (IO2) is regiospecifically substituted by nucleophilic fluoride to provide the corresponding fluoroaryl derivatives. No-carrier-added [F-18]fluoride ion derived from anhydrous [F-18](F/Kryptofix, [F-18]CsF or a quaternary ammonium fluoride (e.g., Me4NF, Et4NF, n-Bu4NF, (PhCH2)4NF) exclusively substitutes the iodyl moiety in these derivatives and provides high specific activity F-18 labeled fluoroaryl analogs. Iodyl derivatives of a benzothiazole analog and 6-iodyl-L-dopa derivatives have been synthesized as precursors and have been used in the preparation of no-carrier-added [F-18]fluorobenzothiazole as well as 6-[F-18]fluoro-L-dopa.
    Type: Application
    Filed: July 13, 2009
    Publication date: July 21, 2011
    Applicant: The Regents of the University of California
    Inventors: Nagichettiar Satyamurthy, Jorge R. Barrio
  • Publication number: 20110171700
    Abstract: The present invention relates to a multi-stage process for producing substituted, optically active alcohols, comprising an enzyme-catalyzed synthesis step, in particular a synthesis step which is catalyzed by an alcohol dehydrogenase. The inventive method is particularly suitable for producing phenylephrine, i.e. 3-[(1R)-1-hydroxy-2-methylamino-ethyl]-phenol.
    Type: Application
    Filed: September 15, 2009
    Publication date: July 14, 2011
    Applicant: BASF SE
    Inventors: Michael Breuer, Andreas Pletsch, Bernhard Hauer, Wolfgang Siegel
  • Publication number: 20110172432
    Abstract: The invention relates to the field of chemistry, especially organic chemistry, and more specifically the field of heterogeneous palladium catalysts used to catalyse chemical reactions involving the formation of carbon-carbon bonds. The invention also relates to a method for synthesising a heterogeneous palladium catalyst that can catalyse a C—C coupling reaction, the method essentially including steps of providing a solid substrate onto which groups of formula —PR1R2, wherein R1 is an optionally substituted alkyl group, or an optionally substituted cycloalkyl group, et R2 is an optionally substituted aryl group or an optionally substituted heteroaryl group, have been covalently bonded, and incorporating a catalytically effective amount of palladium into the resulting substituted substrate. The invention further relates to the resulting catalysts and to the uses thereof in C—C coupling reactions.
    Type: Application
    Filed: April 11, 2008
    Publication date: July 14, 2011
    Applicants: UNIVERSITE DE HAUTE ALSACE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Claude Le Drian, Jean-Michel Becht, Stéphane Schweizer
  • Patent number: 7897820
    Abstract: A process for preparing Erianin (Dihydro Combretastation A-4), wherein 3,4,5-trimethoxy benzaldehyde is converted to phosphonium salt or phosphonate ester or the likes thereof, then reacted with isovanillin (3-hydroxyl-4-methoxyl benzaldehyde) including a protected hydroxyl in the 3-position, followed by hydrogenation and deprotection.
    Type: Grant
    Filed: July 12, 2006
    Date of Patent: March 1, 2011
    Assignee: Zhe Jiang Cell Biomedical Research Co., Ltd.
    Inventors: Yiping Li, Shuangxi Liu
  • Publication number: 20110040093
    Abstract: The invention relates to a process for the preparation of compounds of general formula (III), wherein R represents fluorine or chlorine atom and X represents chlorine or bromine atom, by halogenation of cyclopropyl benzyl ketone of general formula (II), wherein R represents fluorine or chlorine atom and the halogenation is carried out in the mixture of aqueous hydrogen halide and aqueous hydrogen peroxide in the presence of a water miscible solvent or in the presence of a phase transfer catalyst; or the halogenation is carried out in the mixture of sulfuric acid and an alkali metal salt of aqueous hydrogen halide. The process can be applied preferably on industrial scale.
    Type: Application
    Filed: November 27, 2008
    Publication date: February 17, 2011
    Inventors: Tibor Mezei, Gyula Lukács, Enikó Molnár, József Barkóczy, Balázs Volk, Márta Porcs-Makkay, János Szulágyi, Mária Vajjon
  • Publication number: 20110009638
    Abstract: Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture comprising a compound of Formula 2, a compound of Formula 3, a base comprising at least one compound selected from the group consisting of alkaline earth metal hydroxides of Formula 4 wherein M is Ca, Sr or Ba, alkali metal carbonates of Formula 4a wherein M1 is Li, Na or K, 1,5-diazabicyclo[4.3.0]non-5-ene and 1,8-diazabicyclo[5.4.0]undec-7-ene, and an aprotic solvent capable of forming a low-boiling azeotrope with water.
    Type: Application
    Filed: April 8, 2009
    Publication date: January 13, 2011
    Applicant: E.I. DU PONT DE NEMOURS AND COMPANY
    Inventor: Gary David Annis
  • Patent number: 7829745
    Abstract: Described herein are methods for synthesizing 1-aryl-2-tetralones in an efficient and highly selective manner. The reaction involves a one-step procedure for coupling an aryl halide to a 2-tetralone, where coupling occurs substantially at the 1-position of the 2-tetralone.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: November 9, 2010
    Assignee: Corning Incorporated
    Inventor: Clemens Rudolf Horn
  • Publication number: 20100184978
    Abstract: A bipyridine compound represented by the formula (1): wherein R1, R2 and R3 each independently represent a C1-C10 alkyl group which may be substituted etc., and R4, R5, R6, R7 and R8 each independently represent a hydrogen atom etc., a transition metal complex obtained by contacting a bipyridine compound represented by the formula (1) with a compound of a transition metal belonging to Group 9, 10 or 11, and a method for production of a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups are bonded to an aromatic ring with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) being structurally different from the above-mentioned aromatic compound (A) and having one or two leaving groups bonded to an aromatic ring, in the presence of the transition metal complex.
    Type: Application
    Filed: June 18, 2008
    Publication date: July 22, 2010
    Inventors: Taku Asaumi, Takashi Kamikawa
  • Patent number: 7687668
    Abstract: Process for preparing 4,4?-difluorobenzophenone, characterized in that, in a first step, fluorobenzene is reacted with formaldehyde under catalysis by organic sulphonic acids to give difluorodiphenylmethane, the product obtained is isolated, and, in a second step, oxidized with nitric acid to give 4,4?-difluorobenzophenone. 4,4?-Difluorobenzophenone (4,4?-DFBP) is the central starting material for the preparation of aromatic polyether ketones.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: March 30, 2010
    Assignee: Evonik Fibres GmbH
    Inventors: Harald Rögl, Markus Ungerank
  • Publication number: 20100048727
    Abstract: Novel perfluoroketone compounds of formula [I] and [Ia] are described. Also described are uses thereof, such as for inhibition of phospholipase A2 activity. Therapeutic uses thereof are also described, such as for the treatment of neural conditions and/or inflammatory conditions, such as demyelinating (e.g., multiple sclerosis) and neural injury (e.g., spinal cord injury).
    Type: Application
    Filed: April 4, 2008
    Publication date: February 25, 2010
    Inventors: Samuel David, Athena Kalyvas, Ruben Lopez-Vales, George Kokotos, Violetta Constantinou-Kokotou, Constantinos Baskakis, Christoforos G. Kokotos, Edward A. Dennis, Daren Stephens
  • Publication number: 20090234164
    Abstract: SBF derivatives, which can be represented with the following formula: SBF-X wherein: with m=0, 1, 2 or 3; p=positive integer, preferably 1, 2 or 3, with (p+1) being the valency of K; n=positive integer, preferably 1, 2 or 3; L: is the same or different and independently represents C, PR, AsR, SbR, BiR, S, Se, Te, S?Y, Se?Y or Te?Y; Y: is the same or different and independently represents O, S, Se or Te; K: is the same or different and independently represents a chemical bond or a group selected from O, S, BR(2?p), N, NR(2?p), R(2?p)P?O, B3O3, (PR)3N3, CR(3?p), CR(3?p)(C6H4)(p+1), SiR(3?p)(C6H4)(p+1) with (2?p) and (3?p) being a positive integer including zero; alkene, substituted alkene, alkyne, substituted alkyne, aromatic or R substituted aromatic, heteroaromatic or R substituted heteroaromatic or a group resulting from benzene and non benzene, monocyclic and polycyclic hydrocarbons, which can be bivalent, trivalent or of higher valency; or a combination of two, three or four of the above mentioned gro
    Type: Application
    Filed: July 15, 2005
    Publication date: September 17, 2009
    Applicant: Merck Patent GmbH
    Inventors: Liliana Bagala'Rampazzo, Giulia Fioravanti, Leonardo Mattiello
  • Publication number: 20090177014
    Abstract: Process for preparing 4,4?-difluorobenzophenone, characterized in that, in a first step, fluorobenzene is reacted with formaldehyde under catalysis by organic sulphonic acids to give difluorodiphenylmethane, the product obtained is isolated, and, in a second step, oxidized with nitric acid to give 4,4?-difluorobenzophenone. 4,4?-Difluorobenzophenone (4,4?-DFBP) is the central starting material for the preparation of aromatic polyether ketones.
    Type: Application
    Filed: July 27, 2006
    Publication date: July 9, 2009
    Inventors: Harald Rogl, Markus Ungerank
  • Patent number: 7553924
    Abstract: The present invention mainly relates to a carbon-carbon bond formation catalyzed by a complex comprising a novel and stable ligand and a metal center. The ligand uses a ring, particularly a phenyl group, or a hydrocarbon group to link an amino group and PR1R2, NR1R2, OR1, SR1, or AsR1R2 group for stabling the structure of the ligand.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: June 30, 2009
    Assignee: National Sun Yat-Sen University
    Inventor: Lan-Chang Liang
  • Publication number: 20080188688
    Abstract: A process for the production of organic substances, including the steps of providing at least a two-phase system, in which selected reactants are reacted in the presence of a phase transfer catalyst, where one of the phases is an organic solvent with a log P value, at 20° C., of more than 2.6, is provided.
    Type: Application
    Filed: February 1, 2008
    Publication date: August 7, 2008
    Inventors: Hendrik Huesken, Paul Birnbrich, Rainer Hoefer
  • Patent number: 7312331
    Abstract: Stable carbene ligands are provided having a carbene center flanked by a quaternary carbon and an amino group, and having utility in the preparation of various transition metal complexes.
    Type: Grant
    Filed: June 7, 2006
    Date of Patent: December 25, 2007
    Assignee: The Regents of the University of California
    Inventors: Guy Bertrand, Vincent Lavallo, Yves Canac
  • Patent number: 7253323
    Abstract: A process for preparing benzophenones of the formula I, where X may be chlorine, hydroxyl, methoxy or C1-C6-alkylcarbonyloxy, and Y may be chlorine or bromine, by reacting an acid chloride of the formula II where X and Y are as defined above with 3,4,5-trimethoxytoluene, which comprises carrying out the reaction in the presence of a) an aromatic hydrocarbon as a diluent and b) from 0.01 to 0.2 mol % of an iron catalyst, based on the acid chloride, c) at a temperature between 60° C. and the boiling point of the particular diluent.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: August 7, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Volker Maywald, Nico Hoffmann, Michael Keil, Uwe Josef Vogelbacher, Jan Hendrik Wevers
  • Patent number: 7227042
    Abstract: The present invention provides a method of preparing 1-acetyl-1-chlorocyclopropane from 1,3 dichloro-2-pentanone by reaction with base in the presence of a phase transfer catalyst. The reaction may be run in the presence or absence of an organic solvent and in a continuous or batch process.
    Type: Grant
    Filed: April 6, 2004
    Date of Patent: June 5, 2007
    Assignees: Bayer CropScience LP, Bayer CropScience Aktiengesellschaft
    Inventors: Joe J. Hanson, David M. Mayes, Klaus Stroech, Shekhar V. Kulkarni
  • Patent number: 7119234
    Abstract: The present invention relates to a method for the preparation of as 1-(4-Chlorophenyl)-4,4-dimethylpent-1-ene-3-one, also known as Phenyl aldol. The process of the present invention utilizes catalysts. The process enables the manufacture of the Phenyl aldol in the absence of a solvent and without crystalization or filtration steps. Yields in the range of about greater than 95% with purities in the range of about greater than 95% have been obtained with the present invention.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: October 10, 2006
    Assignee: Bayer Cropscience LP
    Inventors: Shekhar V. Kulkarni, Joe J. Hanson
  • Patent number: 7115762
    Abstract: This invention relates to a recyclable palladacycle catalyst of formula in which each is a single bond or a double bond, provided that if one is a double bond, its neighboring is not a double bond; each of X and Z, independently, is —P(R?)—, —S—, —N(R?)—, or —N?, in which R? is alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; each of Y1 and Y2, independently, is an anion of an organic or inorganic acid; each of X1, X2, X3, Z1, Z2, and Z3, independently, is —C?, —CR?—, in which R? is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl; and each of R1, R2, R3, R4, R5, R6, R7, and R8, independently, is H, alkyl, aryl, cyclyl, heteroaryl, or heterocyclyl, or R1, X, X1, and R2, together form a 3–8 membered ring, or R2, X1, X2, and R3, together form a 3–8 membered ring, or R3, X2, X3, and R4, together form a 3–8 membered ring, or R5, Z, Z1, and R6, together form a 3–8 membered ring, or R6, Z1, Z2, and R7, together form a 3–8 membered ring, or R7, Z2, Z3, and R8, together form a 3–8 membered ring; provided t
    Type: Grant
    Filed: July 2, 2004
    Date of Patent: October 3, 2006
    Assignee: Academia Sinica
    Inventor: Fen-Tair Luo
  • Patent number: 7087791
    Abstract: An ecofriendly process for acylation of an alkylated benzene derivative has increased selectively towards para position and comprises a step of reacting the alkylated benzene derivative with an acylating agent in the presence of nitrobenzene, dichlorobenze, dimethylsulfolane, and/or benzotrile, and a crystalline alumino silicate catalyst having general formula M2/nO.Al2O3.xSiO2.wH2O, wherein M is an alkali cation, a rare earth cation, and/or a proton, wherein the Si/Al ratio is in the range of 5.5 to 20, wherein the step of reacting is performed at temperature between 80° to 140° C. for 5 to 25 hours. In a further step, the solid catalyst is separated from the reaction mixture of step, and in yet another step, the acylated alkyl benzene derivative is separated from the mixture.
    Type: Grant
    Filed: October 2, 2003
    Date of Patent: August 8, 2006
    Assignee: Council of Scientific and Industrial Reasearch
    Inventors: Raksh Vir Jasra, Beena Tyagi, Yogiraj Mansukhlal Badheka