Benzene Ring Containing Patents (Class 568/308)
  • Patent number: 9650325
    Abstract: Provided are a novel compound, preparing method thereof, and use thereof as inhibitor of histone demethylase. The compound represented by Chemical Formula 1 has activity which inhibits histone demethylase and thus is capable of specifically and effectively inhibit activity of histone demethylase.
    Type: Grant
    Filed: April 2, 2014
    Date of Patent: May 16, 2017
    Assignees: SNU R&DB FOUNDATION, INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY, KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Dong-Chan Oh, Seong-Hwan Kim, Jongheon Shin, Hak Cheol Kwon, So Hee Kwon
  • Patent number: 9624324
    Abstract: The present invention relates to a new metal complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R5 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R5 may be linked to each other to form a ring; R6-R9 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 arylox
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: April 18, 2017
    Assignee: ARLANXEO Netherlands B.V.
    Inventors: Alexandra Berthoud, Victor Quiroga Norambuena, Gerhard Van Doremaele, Martin Alexander Zuideveld, Philip Mountford, Richard Thomas William Scott
  • Patent number: 9546233
    Abstract: A metal complex of the formula (1) CyAMX(L)n??(1) wherein Cy is a cyclopentadienyl-type ligand, M is a metal of group 4; A is an amidine-containing ligand moiety, represented by formula 2: wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group 15, through which Sub2 is bonded to the imine carbon atom; X is an allyl borate ligand derived from a conjugated diene ligand, D, and a borane, B and L is a neutral Lewis basic ligand wherein the number of said metal ligands “n” is in the range of 1 to the amount that specifies the 18-electron rule.
    Type: Grant
    Filed: May 7, 2014
    Date of Patent: January 17, 2017
    Assignee: ARLANXEO NETHERLANDS B.V.
    Inventors: Richard Thomas William Scott, Martin Alexander Zuideveld, Philip Mountford
  • Patent number: 9012230
    Abstract: The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: April 21, 2015
    Assignee: Korea Institute of Science and Technology
    Inventors: Sehoon Kim, Ick Chan Kwon, Jai Kyeong Kim, Chang-Keun Lim, Jeongyun Heo
  • Patent number: 8969626
    Abstract: A compound of the general formula X-[Q-W—(CH?CH)n—(CH2)2-L]m (I) in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing group; n represents 0 or an integer of from 1 to 4; L represents a leaving group; and m represent an integer of from 1 to 8. The compounds find use in the conjugation of biological molecules.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: March 3, 2015
    Assignee: Polytherics Limited
    Inventor: Antony Godwin
  • Publication number: 20150004108
    Abstract: The present invention relates to a novel composition comprising danielone and derivatives thereof as well as to the use of such compositions in skin lightening. More particularly, the present invention relates to danielone and derivatives thereof for use in topical compositions for smoothening skin color irregularities, for reducing melanin formation in the human skin, for lightening/brightening human skin and/or for treatment of pigmentation disorders which comprises topically administering an effective amount of danielone and derivatives thereof to the appropriate skin area of a person in need of such beautifying agent, or treatment.
    Type: Application
    Filed: December 28, 2012
    Publication date: January 1, 2015
    Inventors: Remo Campache, Piero Geotti-Bianchini, Hugo Ziegler
  • Patent number: 8920715
    Abstract: An antimicrobial solution for disinfecting instruments in an automatic sterilization device, the solution comprising: a peracid reaction product formed in situ from combining a liquid acetyl donor with a solid source of peroxide, wherein the in situ reaction takes place in the sterilization device, along with a containment and delivery ampule for use in an automatic sterilization device, and methods for disinfecting a medical instrument employing the inventive antibacterial solution.
    Type: Grant
    Filed: August 7, 2006
    Date of Patent: December 30, 2014
    Assignee: Hemostasis, LLC
    Inventors: Keith Allen Roberts, Carl William Hahn, Gabriel P. Kern, Ryan A. Hoitink, Robert Orvin Crowder, John Henry Burban
  • Publication number: 20140350287
    Abstract: The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by means of new synthetic intermediates.
    Type: Application
    Filed: August 12, 2014
    Publication date: November 27, 2014
    Inventors: Stefano Tartaggia, Andrea Caporale, Ottorino De Lucchi
  • Publication number: 20140274952
    Abstract: The present invention relates to novel heterocyclic alkanol derivatives, to processes for these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
    Type: Application
    Filed: November 23, 2012
    Publication date: September 18, 2014
    Applicant: BAYER INTELLCTUAL PROPERTY GMBH
    Inventors: Sebastian Hoffmann, Hendrik Helmke, Gorka Peris, Friedrich Carl Nising, Tomoki Tsuchiya, Alexander Sudau, Jürgen Benting, David Bernier
  • Patent number: 8828908
    Abstract: Bicyclic dione compounds of formula (I), and derivatives thereof, which are suitable for use as herbicides.
    Type: Grant
    Filed: May 27, 2008
    Date of Patent: September 9, 2014
    Assignee: Syngenta Limited
    Inventors: Christopher John Mathews, Matthew Brian Hotson, Alan John Dowling, James Nicholas Scutt, Mangala Govenkar, Lee Challinor
  • Patent number: 8822732
    Abstract: This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: September 2, 2014
    Assignee: AndroScience Corporation
    Inventors: Charles C-Y Shih, Toshio Kitamura, Qian Shi, Toshiyuki Kawashima, Hui-Kang Wang
  • Patent number: 8784853
    Abstract: Disclosed is the use of benzotropolone derivatives of formula (1), wherein R1, R2 and R7 independently from each other are hydrogen; C1-C3alkyl; or COR8; R3 is hydrogen; or COOR9 R4 is hydrogen; or C1-C3alkyl; R5 is hydrogen; hydroxy; C1-C3-alkoxy; or -0-(CO)—R10; R6 is hydrogen; C1-C3alkyl; or COR8; or R5 and R6 together may form a five or six membered ring; or R6 and R7 together form a five or six membered ring; and R8, R9, R10 independently of each other are C1-C30alkyl; for protecting body-care and household products from photolytic and oxidative degradation.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: July 22, 2014
    Assignee: BASF SE
    Inventors: Barbara Wagner, Oliver Reich, Alexander Mantler, Reinhold Öhrlein, Walter Fischer, Albert Schneider
  • Patent number: 8779206
    Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 15, 2014
    Assignee: Innovative Surface Technologies, LLC
    Inventors: Patrick E. Guire, Kristin Taton, Jie Wen
  • Patent number: 8779207
    Abstract: The present subject matter relates to methods for the synthesis of [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and fullerene derivatives in a yield of at least 40%.
    Type: Grant
    Filed: August 31, 2012
    Date of Patent: July 15, 2014
    Assignee: Nano and Advanced Materials Institute Limited
    Inventors: Ka Ming Ng, Jianle Zhuang, Nai Wen Tseng, Yong Yu
  • Patent number: 8772347
    Abstract: A method for promoting proliferation and/or migration of skin cells includes providing a composition containing a compound of formula (I) below; and administrating to the skin cells the composition.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: July 8, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Hui-Min Wang, Chung-Yi Chen, Chien-Chih Chiu, Yi-Ting Chou
  • Publication number: 20140141973
    Abstract: The present invention relates to alkyl- and aryl-substituted 2-[2-chloro-4-(dihalo-phenoxy)-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds of formula I as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound.
    Type: Application
    Filed: July 12, 2012
    Publication date: May 22, 2014
    Applicant: BASF SE
    Inventors: Jochen Dietz, Richard Riggs, Nadege Boudet, Jan Klaas Lohmann, Ian Robert Craig, Egon Haden, Erica May Wilson Lauterwasser, Bernd Mueller, Wassilios Grammenos, Thomas Grote
  • Patent number: 8709281
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; and R3-R9 are as described in the disclosure. Also featured are liquid crystal compositions comprising a chiral dopant compound represented by any of Structure 2-4 as described in the disclosure.
    Type: Grant
    Filed: August 24, 2012
    Date of Patent: April 29, 2014
    Assignee: Kent State University
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Publication number: 20140058126
    Abstract: The present invention relates to a new process for the preparation of 2,4,5-trifluorophenylacetic acid and salts thereof by means of new synthetic intermediates.
    Type: Application
    Filed: January 30, 2013
    Publication date: February 27, 2014
    Applicant: F.I.S. - FABRICA ITALIANA SINTETICI S.P.A.
    Inventor: F.I.S. -Fabrica Italiana Sintetici S.p.A.
  • Publication number: 20140031373
    Abstract: The present invention relates to novel substituted pyrimidine derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.
    Type: Application
    Filed: November 28, 2011
    Publication date: January 30, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Carl Friedrich Nising, Graham Holmwood, Hendrik Helmke, Gorka Peris, Tomoki Tsuchiya, Alexander Sudau, Jürgen Benting, Peter Dahmen, Ulrike Wachendorff-Neumann
  • Publication number: 20140012027
    Abstract: A method for producing a fluorine-containing substituted compound, the method including: introducing an organofluorine compound and an organolithium compound into a microreactor provided with a flow path capable of mixing a plurality of liquids, to thereby obtain a reaction product; and introducing, into the microreactor, the reaction product and an electrophile exhibiting electrophilic effect on the reaction product, to thereby obtain a fluorine-containing substituted compound.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicants: Taiyo Nippon Sanso Corporation, Kyoto University
    Inventors: Junichi YOSHIDA, Aiichiro NAGAKI
  • Patent number: 8618333
    Abstract: A compound of the general formula X-[Q-W—(CH?CH)n—(CH2)2-L]m (I) in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing group; n represents 0 or an integer of from 1 to 4; L represents a leaving group; and m represent an integer of from 1 to 8. The compounds find use in the conjugation of biological molecules.
    Type: Grant
    Filed: July 1, 2011
    Date of Patent: December 31, 2013
    Assignee: Polytherics Limited
    Inventor: Antony Godwin
  • Patent number: 8614357
    Abstract: SBF derivatives, represented with the following formula: SBF-X wherein: with m=0, 1, 2 or 3; p=positive integer,; n=positive integer; L: is the same or different and independently represents C, PR, AsR, SbR, BiR, S, Se, Te, S?Y, Se?Y or Te?Y; Y: is the same or different and independently represents O, S, Se or Te; K: is the same or different and independently represents a chemical bond or a group selected from O, S, BR(2?p), N, NR(2?p), R(2?p)P?O, B3O3, (PR)3N3, CR(3?p), CR(3?p)(C6H4)(p+1), SiR(3?p)(C6H4)(p+1) alkyne, substituted alkyne, alkyne, substituted alkyne, aromatic or R substituted aromatic, heteroaromatic-or a combination of two, three or four of the above mentioned groups; SBF: spiro-compound of formula (I): R, A, B, C, D: is the same or different and independently represents H, deuterium, F, Cl, Br, I, CN, a linear, branched or cyclic alkyl, alkoxy or thioalkoxy chain, or a combination from two, three or four of these systems; two or more substituents R can form a further monocyclic or
    Type: Grant
    Filed: July 15, 2005
    Date of Patent: December 24, 2013
    Assignee: Merck Patent GmbH
    Inventors: Liliana Bagala'Rampazzo, Giulia Fioravanti, Leonardo Mattiello
  • Publication number: 20130331593
    Abstract: Treprostinil is prepared by a process which involves Pauson-Khan cyclization of an an alkene-substituted, alkyne-substituted benzene corresponding to formula: (I) where PMB represents para-methoxy benzyl protecting group and R1 and R2 are alcohol protecting groups. Following cyclization, the resulting compound can be subjected to several chemical trans-formations followed by alkylation, hydrolysis and salt formation to yield treprostinil sodium. The use of para-methoxybenzyl group as the phenolic protecting group confers several process advantages that result in simplified purification of the final product and improved yields.
    Type: Application
    Filed: July 22, 2011
    Publication date: December 12, 2013
    Applicant: ALPHORA RESEARCH INC.
    Inventors: Graham Mcgowan, Walter Giust, Danielle Marie Di Donato, Teng-Ko Ngooi, Jan Oudenes
  • Publication number: 20130330408
    Abstract: The present invention generally relates to improvements in the bioavailability and/or solubility of coenzyme Q10. For example, the present invention relates to methods for preparing particulate compositions including coenzyme Q10 that generally comprise dispersing and/or dissolving the coenzyme Q10 throughout a suitable solvent, and combining the coenzyme Q10 and an encapsulating (e.g., microencapsulating) agent. The present invention also generally relates to particulate compositions comprising coenzyme Q10 that exhibit improved bioavailability and/or solubility as compared to previous coenzyme Q10 products.
    Type: Application
    Filed: March 16, 2012
    Publication date: December 12, 2013
    Applicant: PARTICLE DYNAMICS INTERNATIONAL, LLC
    Inventor: Irwin C. Jacobs
  • Patent number: 8604251
    Abstract: The invention pertains to novel oligofunctional photoinitiators of the formula (1) or (1A). R1 and R2 are methyl or together are —(CH2)5—; and n is 2 or 3, and the solvent in (1A) is water or an organic solvent; and their use in photopolymerizable compositions, in particular inks.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: December 10, 2013
    Assignee: BASF SE
    Inventors: Ulrich Berens, Jean-Luc Birbaum, Katia Studer
  • Publication number: 20130296422
    Abstract: Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents —CHO, —C(?O)R5, —COOR5 (wherein R5 represents a C1-7 alkyl group), —CH2OH or —COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.
    Type: Application
    Filed: November 1, 2011
    Publication date: November 7, 2013
    Applicant: ARIGEN PHARMACEUTICALS, INC.
    Inventors: Hiroyuki Saimoto, Kiyoshi Kita, Yoshisada Yabu, Masaichi Yamamoto
  • Patent number: 8575386
    Abstract: A method of providing a fragrant odor to an application, comprising the addition thereto of at least one compound of the formula I wherein X and Y are independently selected from the group consisting of —CR1R2R3, —NR4R5 and —OR6, wherein R1 to R5 are selected from H and essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom, and R6 is selected from essentially hydrocarbon moieties that optionally comprise at least one oxygen, nitrogen or silicon atom; and, A is an essentially hydrocarbon moiety that optionally comprises at least one oxygen, sulphur, nitrogen or silicon atom, with the proviso that the compound A-CHO is a fragrant aldehyde. The use of these compounds in laundry, household and personal care products confers a long-lasting freshness.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: November 5, 2013
    Assignee: Givaudan S.A.
    Inventor: Felix Flachsmann
  • Patent number: 8563779
    Abstract: A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: October 22, 2013
    Assignee: Bayer CropScience AG
    Inventors: Hartmut Ahrens, Andreas Van Almsick, Elmar Gatzweiler, Dieter Feucht, Isolde Haeuser-Hahn, Stefan Lehr, Christopher Hugh Rosinger
  • Publication number: 20130272978
    Abstract: The present invention relates to the use of dihydroxyacetone monoethers as self-tanning substance, to preparations comprising dihydroxyacetone monoethers, and to certain dihydroxyacetone monoethers and to a process for the preparation thereof.
    Type: Application
    Filed: November 30, 2011
    Publication date: October 17, 2013
    Applicant: MERCK PATENT GMBH
    Inventors: Philipp Buehle, Thomas Rudolph
  • Patent number: 8535689
    Abstract: A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.
    Type: Grant
    Filed: October 1, 2008
    Date of Patent: September 17, 2013
    Assignee: The Trustees of Princeton University
    Inventors: Bonnie Bassler, Martin Semmelhack, Douglas A. Higgins, Megan Eileen Bolitho, Kristina M. Kraml, Wai-Leung Ng
  • Publication number: 20130230473
    Abstract: The present invention relates to the use as a preserving agent, in particular in cosmetic or dermatological composition, of at least one compound of formula (I): in which:—X represents ?O or —OH;—R1 represents a hydrogen atom or a methyl;—R2 represents a hydrogen atom, a methyl or an ethyl;—R3 represents a C1-C12, saturated or unsaturated, linear hydrocarbon-based radical, optionally substituted with a hydroxyl group (OH); with the exclusion of the compound of formula (I) in which X represents ?O, R1=methyl, R2=H and R3=—(CH2)6—CH3. The invention also relates to certain novel compounds and to the cosmetic or dermatological compositions comprising same.
    Type: Application
    Filed: October 6, 2011
    Publication date: September 5, 2013
    Applicant: L'Oreal
    Inventors: Maria Dalko, Laurent Gilbert
  • Publication number: 20130210024
    Abstract: The present technology relates to a method of treating cancer by sensitizing human tumours to DNA damaging therapies through activating FBXO32 expression. Transactivation of FBXO32 through the inhibition of EZH2, a histone methyltransferase, decreases p21 protein induction which results in the sensitization of human tumours to chemotherapy. The method further provides a prognostic method to determine if a combination treatment would be effective.
    Type: Application
    Filed: October 14, 2011
    Publication date: August 15, 2013
    Applicant: Agency for Science, Technology and Research
    Inventors: Qiang Yu, Zhenlong Wu
  • Patent number: 8496857
    Abstract: The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: July 30, 2013
    Assignee: Innovative Surface Technologies, Inc.
    Inventors: Patrick E. Guire, Kristin Taton, Jie Wen, Laurie R. Lawin
  • Patent number: 8487137
    Abstract: The invention describes novel crosslinking compounds that include photoactivatable moieties. Several families of compounds are disclosed that can include one or more hydrophilic moieties that help to solubilize the compounds in aqueous environments.
    Type: Grant
    Filed: July 7, 2010
    Date of Patent: July 16, 2013
    Assignee: Innovative Surface Technologies, LLC
    Inventors: Patrick E. Guire, Kristin Taton, Jie Wen
  • Publication number: 20130123544
    Abstract: A composition for promoting proliferation and/or migration of skin cells includes a compound of formula (I): or a pharmaceutically acceptable salt or ester thereof.
    Type: Application
    Filed: April 12, 2012
    Publication date: May 16, 2013
    Applicant: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hui-Min Wang, Chung-Yi Chen, Chien-Chih Chiu, Yi-Ting Chou
  • Publication number: 20130096209
    Abstract: The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product.
    Type: Application
    Filed: April 15, 2011
    Publication date: April 18, 2013
    Applicants: Kraft Foods Global Brands LLC, Chromocell Corporation
    Inventors: David Hayashi, William P. Jones, Jane V. Leland, Peter H. Brown, Joseph Gunnet, Daniel Lavery, Louise Slade, Kambiz Shekdar, Jessica Langer
  • Patent number: 8414870
    Abstract: Substituted benzylidene 2,4-pentanediones are found to provide stabilization to otherwise photosensitive compounds and compositions.
    Type: Grant
    Filed: December 5, 2011
    Date of Patent: April 9, 2013
    Assignee: Sytheon, Ltd.
    Inventor: Ratan K. Chaudhuri
  • Patent number: 8410177
    Abstract: A compound has Formula VIII where, X is —C(O)R, —C(O)OR, —CN, —NO2, —S(O)2R?, —P(O)(OR)2; each R is individually H, alkyl, or alkenyl; R? is alkyl or akenyl; R1 is aryl, alkenyl, arylalkenyl, heterocyclyl, or heteroaryl; and R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are individually H, alkoxy, or hydroxy. In some cases, X is NO2. Pharmaceutical compositions of the compound of Formula VIII with a pharmaceutically acceptable carrier may be prepared. The compounds may be used for inhibition of cyclooxygenase-2.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: April 2, 2013
    Assignee: Indian Institute of Technology Bombay
    Inventors: Irishi N. N. Namboothiri, Narasimham Ayyagari, Deena Jose
  • Publication number: 20130071370
    Abstract: Method of identifying and using compounds which inhibit the expression or activity of micro-RNAs for preventing and/or attenuating ageing, and/or for hydrating skin. An in vitro method for screening for candidate compounds for preventing and/or attenuating ageing of the skin, and/or for hydrating the skin, includes the following steps: a. bringing at least one test compound in contact with a sample of keratinocytes; b. measuring the expression or the activity of at least one microRNA in the keratinocytes; c. selecting the compounds for which an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the expression or an inhibition of at least 20%, preferably at least 30%, preferably at least 40% of the activity of at least one microRNA is measured in the keratinocytes treated in a. compared with the untreated keratinocytes.
    Type: Application
    Filed: June 7, 2011
    Publication date: March 21, 2013
    Applicant: CHANEL PARFUMS BEAUTE
    Inventors: Eleonora Candi, Gennaro Melino, Gaelle Saintigny, Christian Mahe
  • Publication number: 20130066048
    Abstract: Described herein is an enriched substance containing a ground edible material comprising one or more concentrated bioactive natural products from plant juice, as well as methods of producing such enriched substances and methods of using such solids to provide beneficial effects to humans or other animals. Enriched foods comprising the enriched substance(s) are also provided. Also provided are non-sorbed natural products such as sugars, fats oils, and carotenoids found in the non-sorbed plant liquor fraction of plant juice.
    Type: Application
    Filed: March 14, 2011
    Publication date: March 14, 2013
    Applicant: Rutgers, The State University of New Jersey
    Inventors: Ilya Raskin, Diana Roopchand, Slavko Komarnytsky
  • Patent number: 8367735
    Abstract: The present invention relates to compounds of formula I or II:—wherein R is an alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group, that may be substituted or unsubstituted, and that optionally includes at least one heteroatom in its carbon skeleton; R1 is hydrogen, or an alkyl, substituted alkyl, alkenyl, alkynyl, aryl, substituted aryl, or aralkyl group; and R2 is an alkyl, alkenyl, alkynyl, aryl, aralkyl, aralkenyl, or aralkynyl group containing 4-12 carbon atoms, that may be substituted or unsubstituted, and that optionally includes at least one heteroatom in its carbon skeleton; provided that in a compound of formula I, when R1 is an iso-propyl or phenyl group, R2 is not an acetyl or tert-butyldimethylsilyl group; and their use in therapeutic, diagnostic and research methods.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: February 5, 2013
    Assignee: Crawford Healthcare Holdings Limited
    Inventors: Stanley M. Roberts, Gabriella M. Santoro
  • Publication number: 20120276651
    Abstract: The present disclosure relates to a sulfonated benzene compound emitting fluorescence by reaction with hydrogen peroxide, aqueous-dispersed fluorescent nanoprobes applicable for real-time detection of hydrogen peroxide, and a fluorescent nanoprobe fabrication method. The fluorescent nanoprobe contains the following sulfonated benzene compound and water.
    Type: Application
    Filed: January 31, 2012
    Publication date: November 1, 2012
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Sehoon KIM, Ick Chan Kwon, Jai Kyeong Kim, Chang-Keun Lim, Jeongyun Heo
  • Publication number: 20120269739
    Abstract: The invention relates to a cosmetic, pharmaceutical, dermatological, nutraceutical or oral cosmetic composition having, as main preserving system, a mild preserving system formed from compounds with a broad antimicrobial spectrum, which have only one pKa, the said pKa being greater than or equal to 10, the said mild preserving system being present in a content strictly greater than or equal to 1% by weight relative to the weight of the said composition.
    Type: Application
    Filed: September 16, 2010
    Publication date: October 25, 2012
    Applicant: L'OREAL
    Inventors: Maria Dalko, Geraldine Lerebour, Sylvie Cupferman
  • Publication number: 20120251460
    Abstract: The present invention relates to the use, in a cosmetic, dermatological or pharmaceutical composition, of at least one compound of formula (I): in which: R2 represents a hydrogen atom or a methyl or ethyl radical; R3 represents a linear C1-C12 alkyl radical, optionally substituted with a hydroxyl group; or a linear C2-C12 alkenyl radical, optionally substituted with a hydroxyl group; as a preserving agent. The invention also relates to certain novel compounds and to the cosmetic, dermatological or pharmaceutical compositions comprising them.
    Type: Application
    Filed: September 16, 2010
    Publication date: October 4, 2012
    Applicant: L'OREAL
    Inventor: Maria Dalko
  • Patent number: 8277903
    Abstract: The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to are methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 2, 2012
    Assignee: Academia Sinica
    Inventors: Tahsin J. Chow, Chung-Chih Wu, Ta-Hsien Chuang, Hsing-Hung Hsieh, Hsin-Hui Huang
  • Publication number: 20120184762
    Abstract: Provided are a process for the preparation of phenyl carbamate derivatives, useful in the treatment of CNS (central nervous system) disorders, an intermediate in the synthesis of the phenyl carbamate derivatives, and a process for preparation of the intermediate.
    Type: Application
    Filed: December 28, 2011
    Publication date: July 19, 2012
    Applicant: Bio-Pharm Solutions Co., Ltd.
    Inventor: Yong Moon Choi
  • Patent number: 8216974
    Abstract: There is provided a fluorine-containing organosulfur compound having an excellent controlling effect on arthropod pests represented by the formula (I): wherein G represents an oxygen atom or a sulfur atom; R2 represents a C1-C4 chain hydrocarbon group which is optionally substituted with a halogen atom, etc.; R3 and R4 independently represent a C1-C4 chain hydrocarbon group or a hydrogen atom; R5 represents a C1-C5 haloalkyl group containing at least one fluorine atom, or a fluorine atom; R6 represents a halogen atom, a cyano group, a nitro group or a -(G1)q-R8 group; R7 represents an amino group etc.; R8 represents a C1-C4 chain hydrocarbon group which is optionally substituted with a halogen atom; m represents an integer of 0 to 5; n represents an integer of 0 to 2; p represents 0 or 1; q represents 0 or 1; and G1 represents an oxygen atom etc.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: July 10, 2012
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Kumamoto, Hiroyuki Miyazaki
  • Publication number: 20120141394
    Abstract: Substituted benzylidene 2,4-pentanediones are found to provide stabilization to otherwise photosensitive compounds and compositions.
    Type: Application
    Filed: December 5, 2011
    Publication date: June 7, 2012
    Applicant: SYTHEON LIMITED
    Inventor: Ratan K. Chaudhuri
  • Publication number: 20120141395
    Abstract: Benzylidene substituted 2,4-pentanedione compounds without having phenolic hydroxyl group(s) are found to provide photostability to otherwise photosensitive compounds and compositions.
    Type: Application
    Filed: December 5, 2011
    Publication date: June 7, 2012
    Applicant: SYTHEON LIMITED
    Inventor: Ratan K. Chaudhuri
  • Patent number: 8119041
    Abstract: The present invention provides a two-photon light-emitting compound represented by formula (1), an optical data recording medium comprising a compound represented by formula (1), a two-photon polymerizable composition comprising a polymerizable monomer or polymerizable oligomer and at least compound represented by formula (1), and a photopolymerization process: X2—(—CR4?CR3—)m—C(?O)—(—CR1?CR2—)n—X1??(1) wherein X1 and X2 may be the same or different and each represent a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group; R1, R2, R3 and R4 each independently represent a hydrogen atom or substituent; some of R1, R2, R3 and R4 may be connected to each other to form at least one ring; and n and m each independently represent an integer of from 1 to 4, with the proviso that when n and m are 2 or more, the plurality of R1's, R2's, R3's, and R4's each may be the same or different.
    Type: Grant
    Filed: September 4, 2002
    Date of Patent: February 21, 2012
    Assignee: Fujifilm Corporation
    Inventors: Masaharu Akiba, Jun Kawamata