Polycyclo Ring System Patents (Class 568/326)
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Patent number: 7285683Abstract: Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response useful to treat a number of physiological conditions.Type: GrantFiled: January 31, 2006Date of Patent: October 23, 2007Assignee: University of ConnecticutInventors: Alexandros Makriyannis, Spyridon P Nikas, Atmaram D Khanolkar
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Patent number: 7265248Abstract: A colchicine derivative and a method of using a colchicine derivative as a pharmacological agent in the treatment of malaria are provided.Type: GrantFiled: April 28, 2006Date of Patent: September 4, 2007Assignee: Technology Innovations, LLCInventors: Jack A. Tuszynski, Stephen H. Curry
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Patent number: 7230139Abstract: The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.Type: GrantFiled: June 10, 2004Date of Patent: June 12, 2007Assignee: Gemin X BiotechnologiesInventors: Jean-Francois Lavallee, Terrence W. Doyle, Elise Rioux, Laurent Belec, Daniel Rabouin, Xavier Billot, Samuel Fortin
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Patent number: 7217844Abstract: The present invention relates to Diterpenoid Compounds, compositions comprising an effective amount of a Diterpenoid Compound, and methods useful for treating or preventing cancer or a neoplastic disorder comprising administering an effective amount of a Diterpenoid Compound. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a cancer cell or neoplastic cell, or for inducing apoptosis in a cancer or neoplastic cell. The compounds, compositions, and methods of the invention are further useful for treating or preventing a fungal infection. The compounds, compositions, and methods of the invention are also useful for inhibiting the growth of a fungus.Type: GrantFiled: December 1, 2003Date of Patent: May 15, 2007Assignee: Gemin X BiotechnologiesInventors: Pierre Beauparlant, Giorgio Attardo, Zhiying Zhang, Angela M. Stafford, Rosa Ubillas, James B. McAlpine, Jean-Francois Lavallee, Samuel Fortin, Sasmita Tripathy
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Patent number: 7153979Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (I) or a salt thereof: wherein R1 represents a hydroxyl group, arylmethyloxy, lower alkoxy, or lower alkanoyloxy, R2 represents lower alkyl, lower alkenyl, —CH2OR5, formyl, —COOR6, or —CH2N(R7)R8, or R1 and R2 may combine with each other to form —O—C(R9)R10—O—CH2—, R3 and R4, which may be the same or different, represent a hydrogen atom, a hydroxyl group, lower alkyl, lower alkenyl, aryl, hydroxymethyl, —N(R11)R12, formyl, —COOR6, or —OR13, or R3 and R4 may combine with each other to form oxo, hydroxyimino, or alkylidene and X represents O, CH2, or NH.Type: GrantFiled: February 24, 2003Date of Patent: December 26, 2006Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
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Patent number: 7119360Abstract: Novel pentaphenylenes having the following general formula are described; These polymers generally exhibit blue electroluminescence and are useful in electronic devices.Type: GrantFiled: October 29, 2003Date of Patent: October 10, 2006Assignee: Max-Plank-SocietyInventors: Klaus Mullen, Andrew C. Grimsdale, Josemon Jacob
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Patent number: 7101917Abstract: Methods of utilizing compounds of general formulas I and II as modulators and affinity labels of the MPTP complex are elucidated. Furthermore, methods for modulating the activity of the MPTP complex, methods for determining the presence of a component of the MPTP complex, and methods for identifying an active agent that modulates the activity of the MPTP complex, specifically methods for identifying an active agent that modulates the activity of the MPTP complex by interacting with the VDAC1 component are identified. Moreover, novel compounds of general formulas I and II are disclosed.Type: GrantFiled: April 5, 2004Date of Patent: September 5, 2006Assignee: Hoffmann-La Roche Inc.Inventors: Andrea Cesura, Emmanuel Pinard
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Patent number: 7087599Abstract: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.Type: GrantFiled: February 14, 2001Date of Patent: August 8, 2006Assignee: Merck & Co., Inc.Inventors: Dann LeRoy Parker, Jr., Ronald W. Ratcliffe, Robert R. Wilkening, Kenneth J. Wildonger
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Patent number: 7057076Abstract: Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response useful to treat a number of physiological conditions.Type: GrantFiled: July 11, 2002Date of Patent: June 6, 2006Assignee: University of ConnecticutInventors: Alexandros Makriyannis, Spyridon P Nikas, Atmaram D Khanolkar
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Patent number: 7053249Abstract: ?-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of cost-effective excitation devices such as LED's. The compounds form fluorescent chelates (complexes) with lanthanide (III) rare earth metal ions (such as Eu3+). The fluorescent complex may be included in a latex microparticle, such as a styrene latex particle. Ideally, the complex has an absorption maximum ? equal to or greater than 360 nm, and the compound is characterized by a pKa<9.0. Kits and methods for detecting target molecules (e.g. immunoassays) are also disclosed. Such methods and kits typically use a ligand for binding to the target molecule and a labeling agent attached to the ligand. The fluorescent complexes described above are at least part of the labeling agent.Type: GrantFiled: October 25, 2002Date of Patent: May 30, 2006Assignee: IDEXX Laboratories, Inc.Inventors: Yerramilli Murthy, Robert H. Suva
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Patent number: 7022664Abstract: The invention relates to 1,2-substituted 2,3-dihydro-1H-5,9-dioxacyclohepta[f]inden-7-ones and 7-substituted benzo[b][1,4]dioxepin-3-ones and to the use of these compounds in fragrance compositions.Type: GrantFiled: April 28, 2003Date of Patent: April 4, 2006Assignee: Givaudan SAInventor: Philip Kraft
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Patent number: 6949557Abstract: The invention relates to the use of novel anthracene based compounds for the inhibition or prevention of the growth or multiplication of cancer cells, and to therapeutic compositions containing such compounds. The invention relates more specifically to the use of hydroanthracene based compounds for the inhibition and/or prevention of cancer of the colon, pancreas, prostate, lung, larynx, ovary, breast, glioblastoma, oral cavity, endothelial cells and leukemias. The agents of the invention form a distinct class, distinct from the anthracene, anthrone or anthraquinone derivatives.Type: GrantFiled: April 29, 2003Date of Patent: September 27, 2005Assignee: Dabur Research FoundationInventors: Asish Kumar Banerjee, Venkatachalam Sesha Giri, Rama Mukherjee, Kamal K. Kapoor, Gautam Desiraju, Manu Jaggi, Anu T. Singh, Sankar Kumar Dutta, Kalapatapu V. V. M. Sairam
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Patent number: 6939845Abstract: The present invention provides a fragrance precursor of formula I: that is capable of forming a fragrant ketone of formula II: and a fragrant lactone of formula III:Type: GrantFiled: June 18, 2001Date of Patent: September 6, 2005Assignee: Givaudan SAInventors: Markus Gautschi, Caroline Plessis, Samuel Derrer
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Patent number: 6903238Abstract: This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: June 7, 2005Assignee: WyethInventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6894073Abstract: The disclosure concerns novel use of diterpene compound as a therapeutic agent of inlfammation, immune disease or cancer. More particularly, the present invention relates to novel use of diterpene compound that include kamebanin, kamebacetal A, kamebakaurin, and exisanin A, which would be effective for the treatment inflammation, immune disease or cancer by inhibiting the production of nitric oxide, prostaglandin, and TNF-a1 through the suppression of NF-k B activity.Type: GrantFiled: December 12, 2001Date of Patent: May 17, 2005Assignee: Korea Research Institute of Bioscience and BiotechnologyInventors: Jung-Joon Lee, Jeong-Hyung Lee, Hang-Sub Kim, Young-Soo Hong, Bang-Yeon Hwang
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Patent number: 6887904Abstract: Substituted arylcycloalkanes, compositions containing them and use thereof. The present invention relates especially to substituted arylcycloalkanes with therapeutic activity, which may be used such as in oncology.Type: GrantFiled: December 4, 2002Date of Patent: May 3, 2005Assignee: Aventis Pharma S. A.Inventors: Patrick Mailliet, Marc Capet, Gilles Tiraboschi, Thomas Caulfield
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Patent number: 6852894Abstract: An oxygen scavenging composition or system is provided comprising an oxygen scavenging material, a photoinitiator, and at least one catalyst effective in catalyzing an oxygen scavenging reaction, wherein the photoinitiator comprises a benzophenone derivative containing at least two benzophenone moieties. A film, a multi-phase composition, a multi-layer composition, a multi-layer film, an article comprising the oxygen scavenging composition, a method for preparing the oxygen scavenging composition, and a method for scavenging oxygen are also provided. Non-extractable benzophenone derivative photoinitiators and methods for preparing same are also provided.Type: GrantFiled: November 7, 2002Date of Patent: February 8, 2005Assignee: Chevron Phillips Chemical Company LPInventor: Ta Yen Ching
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Patent number: 6828159Abstract: The invention relates to the use of carbopyronine compounds of general formula (I) as marker groups in methods for detecting analytes. The invention also relates to novel carbopyronine compounds and to a method for producing same.Type: GrantFiled: October 26, 2001Date of Patent: December 7, 2004Inventors: Karl-Heinz Drexhage, Jutta Arden-Jacob, Jörg Frantzeskos, Alexander Zilles
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Patent number: 6800785Abstract: The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.Type: GrantFiled: October 15, 2003Date of Patent: October 5, 2004Assignee: Merck & Co., Inc.Inventor: Dongfang Meng
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Patent number: 6777447Abstract: Benzylidene cyclohexanone, cyclopentanone and acteone derivatives and therapeutic methods of using same are disclosed. The compounds are non-toxic and exhibit potent anti-inflammatory, antibacterial and antioxidation activity. Also, certain compounds of the invention inhibit glutathione S-transferase (“GST”), but do not irritate the gastrointestinal tract. Pharmaceutical compositions containing the compounds of the invention and pharmaceutically acceptable carriers are also disclosed.Type: GrantFiled: February 27, 2002Date of Patent: August 17, 2004Inventors: Mochammad Samhoedi Reksohadiprodjo, Henk Timmerman, Sardjiman Dummy, Supardjan Amir Margono, Sudibyo Martono, Sugiyanto Dummy, Lukman Rahman Hakim, Nurlaila Dummy, Arief Rahman Hakim, Ika Puspitasari, Arief Nurrochmad, Purwantiningsih Dummy, Oetari Dummy, Tedjo Yuwono
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Publication number: 20040138313Abstract: The invention relates to compounds of the formula (I) 1Type: ApplicationFiled: July 25, 2003Publication date: July 15, 2004Applicant: Aventis Pharma Deutschland GmbHInventors: Claudia Eder, Herbert Kogler, Sabine Haag-Richter
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Patent number: 6686486Abstract: A procedure for oxidizing organic compounds having allylic hydrogen atom(s) involving the steps of reactively contacting the organic compound with a combination of a periodic acid or metal periodate and an alkyl hydroperoxide under conditions of normal as well as elevated pressure of a suitable gas like air. The reaction can conveniently be conducted at temperatures between about 0-65° C. in a cosolvent system of water and organic solvent(s).Type: GrantFiled: August 14, 2000Date of Patent: February 3, 2004Inventors: Padma Marwah, Henry A. Lardy
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Publication number: 20030236167Abstract: Compounds of formula I 1Type: ApplicationFiled: June 5, 2003Publication date: December 25, 2003Inventors: Jurgen Schaetzer, Alain De Mesmaeker, Shy-Fuh Lee
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Publication number: 20030222243Abstract: Fluorinated indenes and 1,7-dihydroindacenes of the general formulae (I) and (II) of negative dielectric anisotropy (&Dgr;&egr;<0) 1Type: ApplicationFiled: April 4, 2003Publication date: December 4, 2003Applicant: Merck Patent GmbHInventors: Lars Lietzau, Melanie Klasen-Memmer, Matthias Bremer
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Patent number: 6620950Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.Type: GrantFiled: September 6, 2002Date of Patent: September 16, 2003Assignee: Florida State UniversityInventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
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Patent number: 6617473Abstract: The invention relates to a preparation process for derivatives by catalytic dehydrogenation of dibenzosuberone derivatives.Type: GrantFiled: February 26, 2002Date of Patent: September 9, 2003Assignee: Haarman & Reimer GmbHInventors: Stefan Lambrecht, Horst Surburg
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Publication number: 20030153465Abstract: The invention relates to novel substituted aryl ketones of the general formula (I) 1Type: ApplicationFiled: July 15, 2002Publication date: August 14, 2003Inventors: Otto Schallner, Stefan Lehr, Hans-Georg Schwarz, Klaus-Helmut Muller, Dorothee Hoischen, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Akihiko Yanagi, Shinichi Narabu, Toshio Goto
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Patent number: 6528489Abstract: The present invention provides a treatment for mammalian diseases characterized by aberrant cell proliferation. The treatment consists of administering therapeutically active dosages of antibiotic inhibitors such as efrapeptin oligopeptides or mycotoxin derivatives including those comprising a-zearalenol structural motifs resulting in inhibition of cell mitosis.Type: GrantFiled: September 21, 2000Date of Patent: March 4, 2003Assignee: Ergon Pharmaceuticals LLCInventor: Adonia E. Papathanassiu
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Patent number: 6518316Abstract: A compound of formula (I), wherein &agr;X is ═O, ═N—OR6, &bgr;NHR or &bgr;OH wherein R6 is H or C1-C6 alkyl, bond a is oriented &ggr; or &dgr; and R is H, C1-C6 alkyl which is unsubstituted or substituted by C6-C10 aryl, or C3-C6 cycloalkyl; &egr; is a bond when &zgr; and &eegr; are not bonds or, when X is ═O, &zgr; and &eegr; are both bonds and &egr; is not a bond; R1 and R2, which are the same or different, are H or a halogen; R3 and R4, which are the same or different, are H, C1-C6 alkyl, C3-C6 cycloalkyl, a heterocyclic group or an aromatic group; bond e is oriented &ggr; or &dgr;; and R5 is C1-C6 alkyl; or formula (Ib), or formula (II), or formula (III), has activity as a cytokine production inhibitor and an inhibitor and an inhibitor of tyrosine kinase.Type: GrantFiled: March 27, 2001Date of Patent: February 11, 2003Assignee: Xenova LimitedInventors: Roya Mansour Sadeghi Guilani, Stephen Keith Wrigley, Sangeeta Bahl, Steven Michael Martin, David Andrew Kau, Jenny Seugkin Tang, Michael Moore, David James Hardick
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Patent number: 6462075Abstract: The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good activity as angiogenesis inhibitors. The present invention also relates to the use of chalcone and its analogs as antitumor/anticancer agents and to treat a number of conditions or disease states in which angiogenesis is a factor, incluidng angiongenic skin diseases such as psoriasis, acne, rosacea, warts, eczema, hemangiomas, lymphangiogenesis, among numerous others, as well as chronic inflammatory disease such as arthritis.Type: GrantFiled: December 26, 2000Date of Patent: October 8, 2002Assignees: The University of Georgia Research Foundation, Inc., Emory UniversityInventors: J. Phillip Bowen, Thomas Phillip Robinson, Tedman Ehlers, David Goldsmith, Jack Arbiser
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Patent number: 6459001Abstract: The subject of the invention is the products of formula (I): in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.Type: GrantFiled: January 25, 2001Date of Patent: October 1, 2002Assignees: Aventis Pharma S.A., GenetechInventors: Serge Bernard, Denis Carniato, Jean-Francois Gourvest, Jean-Georges Teutsch, Jochen Knolle, Hans-Ulrich Stilz, Volkmar Wehner, Sarah C. Bodary, Thomas R. Gadek, Robert S. McDowell, Robert M. Pitti
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Patent number: 6428912Abstract: An improved multilayer light emitting device includes novel compounds for use as the electron transporting layer. In particular, the novel compounds are novel aluminum cheltates (e.g. tris(9-oxidophenalenone) aluminum [Al(9-opo)3] and tris(6-oxidobenzanthrone) aluminum [Al(6-obao)3]. These compounds are electron acceptors having improved thermal stability while in most cases and in most applications maintaining comparable efficiencies. When negatively biased, electrons are infected into the electron transporting layer. The concurrent positive bias on the anode in relation to the cathode causes holes to be injected from the cathode into the hole transporting layer. Electroluminescence is produced and confined generally near the interface between these electron and hole transporting layers an a result of the recombination of the electron and hole pairs.Type: GrantFiled: September 30, 1998Date of Patent: August 6, 2002Assignee: Agere Systems Guardian Corp.Inventor: Robert C. Haddon
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Publication number: 20020087025Abstract: An improved method is described for making 9-deoxy-PGF1-type compounds. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: ApplicationFiled: February 15, 2002Publication date: July 4, 2002Applicant: UNITED THERAPEUTICS CORPORATIONInventors: Robert M. Moriarty, Raju Penmasta, Liang Guo, Munagala S. Rao, James P. Staszewski
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Patent number: 6414167Abstract: The invention relates to a novel octafluorotricyclodecane derivative represented by the general formula (1), where R1 is a hydrogen atom, a halogen atom, a hydrocarbon group or a halogenated hydrocarbon group, m is 0 or 1, and R2 is represented by the general formula (2), where R3 is a hydrogen atom or a hydrocarbon group optionally having a substituent. This octafluorotricyclodecane derivative may be useful as a monomer for producing various functional polymers or as a raw material of the same.Type: GrantFiled: June 19, 2001Date of Patent: July 2, 2002Assignee: Central Glass Company, LimitedInventors: Satoru Miyazawa, Michitaka Ootani, Kentaro Tsutsumi
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Patent number: 6388146Abstract: The polymerizable compound of this invention is represented by general formula (I): where R is H, R′, R′O, R′COO, or R′OCO, R′ is a linear or branched alkyl group or alkenyl group having 1 to about 15 carbon atoms, A1 and A2 are independently a cyclohexane ring or a benzene ring which may include a substituent represented by formula (II) below; X is H or CH3; and Y1, Y2, Y3, and Y4 are independently H, F, Cl, CH3, CH3O, CF3, or CF3O wherein at least two of Y1, Y2, Y3, and Y4 are H and, if both A1 and A2 are cyclohexane rings, at least one of Y1, Y2, Y3, and Y4 is not H: where Y5, Y6, Y7, and Y8 are independently H, F, Cl, CH3, CH3O, CF3, or CF3O, at least two of Y5, Y6, Y7, and Y8 are H.Type: GrantFiled: January 27, 1999Date of Patent: May 14, 2002Assignees: Sharp Kabushiki Kaisha, Kanto Kagaku Kabushiki KaishaInventors: Noriaki Onishi, Aya Miyazaki, Hoyo Mizobe, Masahiko Yoshida, Kenji Suzuki
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Patent number: 6384284Abstract: A description is given of diphenyl compounds of formula wherein R is a camphor or hydantoin derivative; and R1 is hydrogen; or C1-C5alkyl. These compounds are suitable as light stabilizers in cosmetic, pharmaceutical and veterinary formulations.Type: GrantFiled: March 29, 2001Date of Patent: May 7, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Rudolf Zink, Dieter Reinehr, Helmut Luther, Bernd Herzog
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Patent number: 6355815Abstract: A cyclic anthraquinone process for producing hydrogen peroxide using at least two differently substituted 2-alkylanthraquinones and/or their tetrahydro derivatives. The working solution to be used contains (i) at least one reaction carrier from the series 2-(4-methyl-3-pentenyl) anthraquinone (IHEAQ), 2-(4-methylpentyl) anthraquinone (IHAQ) and their di- and tetrahydro derivatives such as, in particular 2-(4-methylpentyl)-&bgr;-tetrahydroanthraquinone (THIHAQ), and (ii) at least one reaction carrier from the series of the 2-(C1- to C5)-alkylanthraquinones, especially 2-ethylanthraquinone (EAQ), and their tetrahydro derivatives. The reaction carriers according to (i) make up 5 to 95 molar %, especially 20 to 50 molar % of all reaction carrier. The method is distinguished by greater H2O2 capacity, improved hydrogenation kinetics and lesser susceptibility to disturbances. A method for making THIHAQ is also disclosed.Type: GrantFiled: July 27, 2000Date of Patent: March 12, 2002Assignee: Degussa AGInventors: Jürgen Glenneberg, Gustaf Goor, Eugen Staab, Hubert Angert
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Patent number: 6344153Abstract: The present invention provides liquid crystal having a spiral coil structure and a dipole moment along its axis and a helical discotic switch using the same, wherein the helicene compound has the structure: wherein X is O, or S and Y is —O—C(═O)CH2—O—R5, wherein R5 is H, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or arylalkyl, wherein R1, R2, R3 and R4 are independently the same or different and are substituted or unsubstituted alkyl, alkenyl, cycloalkyl, aryl, or arylalkyl.Type: GrantFiled: August 27, 1999Date of Patent: February 5, 2002Assignee: The Trustees of Columbia University in the City of New YorkInventors: Thomas J. Katz, Colin P. Nuckolls
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Patent number: 6342196Abstract: A method for synthesizing hydrogen peroxide comprises the steps of: synthesizing an analog of anthraquinone that is miscible or soluble in carbon dioxide; reacting the analog of anthraquinone with hydrogen in carbon dioxide to produce a corresponding analog of tetrahydroquinone; and reacting the analog of tetrahydroquinone with oxygen to produce the hydrogen peroxide and regenerate the analog of anthraquinone. A chemical compound having the formula: wherein R1, R2, R3, R4, R5, R6, R7, and R8 are independently, the same or different, H, RC, or RSRC, wherein RS is a spacer group and RC is a fluoroalkyl group, a fluoroether group, a silicone group, an alkylene oxide group, a fluorinated acrylate group, or a phosphazine group, and wherein at least one of R1, R2, R3, R4, R5, R6, R7, and R8 is not H.Type: GrantFiled: June 29, 1998Date of Patent: January 29, 2002Assignee: University of PittsburghInventors: Eric J. Beckman, Dan Hâncu
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Publication number: 20020010337Abstract: The invention relates to novel stilbene compounds having the general formula (I): 1Type: ApplicationFiled: February 21, 2001Publication date: January 24, 2002Inventors: Jean-Michel Bernardon, Bruno Charpentier
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Patent number: 6340774Abstract: This invention relates generally to non-steroidal estrogen-receptor (ER) antagonists that are useful as therapeutics in the treatment of advanced stage breast cancer. More particularly, this invention relates to the cloning and heterologous expression of genes encoding ER antagonists. This invention also relates to the use of such expression to overproduce the ER antagonist and analogs thereof.Type: GrantFiled: January 31, 2001Date of Patent: January 22, 2002Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Chaitan Khosla, Zhihao Hu, Thomas Marti
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Patent number: 6300376Abstract: Indane dimer compounds and their pharmaceutical use particularly to achieve smooth muscle relaxing activity and/or mast cell stabilizing activity and/or anti-inflammatory activity are described.Type: GrantFiled: June 8, 1998Date of Patent: October 9, 2001Assignee: Venantius LimitedInventors: John Walsh, Neil Frankish, Helen Sheridan, Ronan Farrell, William Byrne
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Patent number: 6277357Abstract: The invention relates to ketotricyclo[5.2.1.0]-decane derivatives of the formula I wherein Phe is a phenyl group which is unsubstituted or substituted by 1 to 5 hydroxyl, alkyl or alkoxy groups having 1 to 10 C atoms, and their preparation and use as UV filters, in particular in cosmetic or pharmaceutical formulations.Type: GrantFiled: October 19, 1993Date of Patent: August 21, 2001Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Michael Schwarz, Ingeborg Stein, Ulrich Heywang, Jürgen Eckstein
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Publication number: 20010011144Abstract: A tetrahydrofluorene, which is represented by the following formula (I) 1Type: ApplicationFiled: January 25, 2001Publication date: August 2, 2001Applicant: ADCHEMCO CorporationInventor: Hiroaki Mori
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Publication number: 20010007045Abstract: A method for synthesizing hydrogen peroxide comprises the steps of: synthesizing an analog of anthraquinone that is miscible or soluble in carbon dioxide; reacting the analog of anthraquinone with hydrogen in carbon dioxide to produce a corresponding analog of tetrahydroquinone; and reacting the analog of tetrahydroquinone with oxygen to produce the hydrogen peroxide and regenerate the analog of anthraquinone.Type: ApplicationFiled: June 29, 1998Publication date: July 5, 2001Inventors: ERIC J. BECKMAN, DAN HANCU
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Publication number: 20010003639Abstract: Disclosed is a positive-type photosensitive composition that has high sensitivity, good latitude in development, and good storage stability and is for use in a direct plate production process using an infrared laser and a novel anionic infrared-ray absorbing agent suitable therefor. This composition comprises (a) an anionic, infrared-ray absorbing agent and (b) a polymeric compound that is insoluble in water but soluble in an aqueous alkaline solution so that the composition becomes soluble in the aqueous alkaline solution when irradiated with the infrared laser. Preferably, (a) the anionic, infrared-ray absorbing agent is (a-1) an anionic metal complex, (a-2) an anionic carbon black, (a-3) an anionic phthalocyanine, or (a-4) a compound represented by the general formula (I) given below. More preferably, from the standpoint of sensitivity, a counter cation of (a) the anionic, infrared-ray absorbing agent has a construction of a thermally decomposable onium salt.Type: ApplicationFiled: March 23, 1999Publication date: June 14, 2001Applicant: Tatsuo NakamuraInventors: TATSUO NAKAMURA, KAZUTO KUNITA, SHIN-ICHI MORISHIMA
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Patent number: 6229048Abstract: A method for treating cancer comprising administering a 1,3,4,6-tetrahydroxy-helianthrone derivative. The compounds can be used in the absence of light irradiation or for photodynamic therapy of solid tumors wherein the tumor site is subjected to light irradiation after administration of the active ingredient. A preferred compound is 10,13-dimethyl-1,3,4,6-tetrahydroxy-helianthrone.Type: GrantFiled: January 31, 2000Date of Patent: May 8, 2001Assignees: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science, New York UniversityInventors: Yehuda Mazur, Gad Lavie
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Patent number: 6221907Abstract: The subject of the invention is the products of formula (I): in which R1, R2, R3, R4, R5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.Type: GrantFiled: February 2, 1999Date of Patent: April 24, 2001Assignee: Hoechst Marion RousselInventors: Serge Bernard, Denis Carniato, Jean-Francois Gourvest, Jean-Georges Teutsch, Jochen Knolle, Hans-Ulrich Stilz, Volkmar Wehner, Sarah C. Bodary, Thomas R. Gadek, Robert S. McDowell, Robert M. Pitti
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Patent number: 6201018Abstract: A triterpene derivative useful for the treatment of hepatic disorders is disclosed. This compound comprises as an active ingredient a triterpene derivative represented by the following formula (IV) or a salt thereof: Y represents a single bond to form a double bond in the ring with Y bonded thereto.Type: GrantFiled: August 26, 1998Date of Patent: March 13, 2001Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazue Sasaki, Nobuto Minowa, Shoji Nishiyama, Hiroyuki Kuzuhara
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Patent number: 6184418Abstract: A method for acylating an aromatic compound, specifically an activated or deactivated aromatic compound, is disclosed. The method is suitable for preparing aromatic ketones. The preparation of a catalyst and novel bismuth compounds is also disclosed. Said aromatic compound acylation method comprises reacting said aromatic compound with an acylating agent in the presence of a catalyst, and is characterised in that the acylation reaction is performed in the presence of an effective amount of at least one bismuth salt of trifluoromethanesulphonic acid.Type: GrantFiled: January 19, 1999Date of Patent: February 6, 2001Assignee: Rhodia ChimieInventors: Jacques Dubac, Hafida Gaspard, Mireille Labrouillere, André Laporterie, Jean-Roger Desmurs, Christophe Le Roux