Oxy Bonded Directly To A Ring Patents (Class 568/33)
  • Patent number: 9801838
    Abstract: Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts of formula (I) and a crystalline form of potassium 2,5 2,5-dihydroxybenzenesulfonic acid are provided.
    Type: Grant
    Filed: March 10, 2015
    Date of Patent: October 31, 2017
    Assignee: AMDERMA PHARMACEUTICALS, LLC
    Inventors: Unni Santhosh, Annadurai Marimuthu Senthilkumar, Bodireddy Mohan Reddy, Rajendran Kamala, Mahender Rao Siripragada
  • Publication number: 20150119586
    Abstract: To provide an industrial method for producing a substituted benzoic acid compound useful as an intermediate of pharmaceutical and agricultural chemicals with high purity and high yield.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 30, 2015
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Hisayoshi Jonishi, Tomohiro Okamoto, Norio Adachi, Akihiko Isogai, Tatsuya Jukurogi, Hideaki Konishi, Fumihiro Fukui
  • Patent number: 9012692
    Abstract: Processes for the preparation of 2,5-dihydroxybenzenesulfonic acid salts of formula (I) and a crystalline form of potassium 2,5 2,5-dihydroxybenzenesulfonic acid are provided.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: April 21, 2015
    Assignee: AmDerma Pharmaceuticals, LLC
    Inventors: Unni Santhosh, Annadurai Marimuthu Senthilkumar, Bodireddy Mohan Reddy, Rajendran Kamala, Mahender Rao Siripragada
  • Patent number: 9012693
    Abstract: Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesized rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: April 21, 2015
    Assignee: Kappa Bioscience AS
    Inventors: Lars Skattebol, Inger Reidun Aukrust, Marcel Sandberg
  • Publication number: 20150087833
    Abstract: An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.
    Type: Application
    Filed: April 11, 2013
    Publication date: March 26, 2015
    Applicants: IHARA CHEMICAL INDUSTRY CO., LTD., KUMIAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Kei Domon, Keiji Toriyabe, Yutaka Ogawa, Junichiro Bessho, Kei Kawamoto, Akira Watanabe, Masaaki Komatsu, Takeshi Matsuda, Seisuke Ito
  • Publication number: 20150045560
    Abstract: Described herein are heterocyclic organic compounds of following formulae: More specifically, described herein are fused heterocyclic naphthalene compounds, polymers based on fused heterocyclic naphthalene compounds, methods for making these compounds, and uses thereof. The compounds described have improved polymerization and stability properties that allow for improved material processibility for use as organic semiconductors (OSCs).
    Type: Application
    Filed: March 28, 2013
    Publication date: February 12, 2015
    Inventors: Mingqian He, Jieyu Hu, Weijun Niu, Adama Tandia
  • Patent number: 8952185
    Abstract: Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: February 10, 2015
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Mitsuhisa Yamano, Mitsutaka Goto, Takahiro Konishi
  • Publication number: 20140066659
    Abstract: A bis(trifluoromethanesulfonyl)ethyl group-bearing compound represented by the following formula [1], [2] or [3]
    Type: Application
    Filed: December 8, 2011
    Publication date: March 6, 2014
    Applicant: Central Glass Company, Limited
    Inventors: Takeo Taguchi, Hikaru Yanai
  • Publication number: 20130345444
    Abstract: Provided is a production method of an optically active dihydrobenzofuran derivative. A production method of an optically active form of a compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof and the like.
    Type: Application
    Filed: February 16, 2012
    Publication date: December 26, 2013
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Mitsuhisa Yamano, Mitsutaka Goto, Takeshi Kajiwara, Hiroyuki Maeda, Takahiro Konishi, Misayo Sera, Yuichiro Kondo, Seiji Yamasaki
  • Patent number: 8536094
    Abstract: Herbicide combinations (A)+(B), if appropriate in the presence of safeners, with an effective content of (A) broad-spectrum herbicides from the group (A1) glufosinate (salts) and related compounds (A2) glyphosate (salts) and related compounds such as sulfosate, (A3) imidazolinones such as imazethapyr, imazapyr, imazaquin, imazamox or their salts and (A4) herbicidal azoles from the group of the protoporphyrinogen oxidase inhibitors (PPO inhibitors) and (B) one or more herbicides from the group consisting of (B0) one or more structurally different herbicides from the abovementioned group (A) or (B1) foliar- and soil-acting herbicides effective against selectively in rice monocotyledonous and dicotyledonous harmful plants (residual action) or (B2) herbicides which are effective selectively in rice against dicotyledonous harmful plants and/or sedges, and/or (B3) foliar-acting herbicides which are effective selectively in rice against monocotyledonous harmful plants, and/or (B4) foliar- and soil-acting herbi
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: September 17, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Erwin Hacker, Hermann Bieringer, Lothar Willms
  • Patent number: 8497227
    Abstract: Diphenylsulfone bridged compounds of the general formula: (1) wherein n is an integer of 1 to 10. Further, there is disclosed a thermal recording material comprising a support and, superimposed thereon, a thermosensitive color forming layer containing a color forming substance for thermal recording consisting of any of the diphenylsulfone bridged compounds and a color forming substance consisting of a colorless or light-colored leuco dye. This thermal recording material excels in the storability, especially wet heat resistance and oil resistance, of image areas and further exhibits excellent characteristics in the storability, especially heat resistance, of undeveloped areas.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: July 30, 2013
    Assignee: Nicca Chemical Co., Ltd.
    Inventors: Hajime Saito, Takeo Hasegawa
  • Publication number: 20130149641
    Abstract: To provide a charge controlling agent for electrophotography, which presents sufficient triboelectric chargeability to a toner, is useful particularly for a color toner and further for a polymerized toner, increases a charge rising rate, has a high electric charge amount, is excellent in charging characteristics, stability over time and environmental stability and yet is safe without posing any problem regarding waste regulations, and a negatively chargeable toner for developing an electrostatic image, which uses such a charge controlling agent and which has a high charging performance.
    Type: Application
    Filed: September 13, 2011
    Publication date: June 13, 2013
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Ikuo Kimura, Masami Ito, Masaya Tojo, Masafumi Asakai
  • Patent number: 8455694
    Abstract: A compound represented by the following formula (1) is provided as a gelling agent for gelatinizing a liquid organic compound: wherein n and m are each independently an integer of 2 to 18, R1 and R3 are each independently a single bond or a branched or linear alkylene group having 1 to 6 carbon atoms, R2 is a branched or linear alkylene group having 3 to 18 carbon atoms, and Z1 and Z2 are each independently a phenylene group or a biphenylene group.
    Type: Grant
    Filed: May 31, 2010
    Date of Patent: June 4, 2013
    Assignee: National University Corporation Yamaguchi University
    Inventors: Hiroaki Okamoto, Yuki Morita
  • Patent number: 8399136
    Abstract: The electrolyte solution for a lithium ion secondary battery according to the present invention contains a nonaqueous solvent, a lithium salt and a compound represented by the general formula (Z) shown below. Thereby, a lithium ion secondary battery having high battery characteristics and simultaneously achieving a high safety as well can be provided. R—SO2—Ar1—O—R1??(Z) wherein Ar1 denotes a substituted or nonsubstituted divalent aromatic group having 5 to 30 atoms of the nucleus(es); R1 denotes a saturated or unsaturated monovalent hydrocarbon group having 1 to 20 carbon atoms; and R denotes a saturated or unsaturated monovalent hydrocarbon group having a perfluoroalkyl group and having 2 to 22 carbon atoms.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: March 19, 2013
    Assignees: Asahi Kasei E-Materials Corporation, Yamaguchi University
    Inventors: Asami Ohashi, Yoshiyuki Ishii, Hiroaki Okamoto, Yuki Morita
  • Patent number: 8350088
    Abstract: To provide a gelling agent containing a fluoroalkyl derivative, a small amount of which can gelatinize or solidify various organic solvents. The gelling agent for organic liquids contains a fluoroalkyl derivative represented by the following formula: wherein each of m, n and x is a positive integer.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: January 8, 2013
    Assignee: National University Corporation Yamaguchi University
    Inventors: Hiroaki Okamoto, Yuki Morita
  • Patent number: 8338076
    Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component (B) which generates acid upon exposure, the acid-generator component (B) including an acid generator (B1) containing a compound having a cation moiety comprising a group represented by general formula (I) (in the formula, R5 represents an organic group having a carbonyl group, an ester bond or a sulfonyl group; and Q represents a divalent linking group).
    Type: Grant
    Filed: November 25, 2009
    Date of Patent: December 25, 2012
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Akiya Kawaue, Yoshiyuki Utsumi, Hideo Hada, Takehiro Seshimo, Kensuke Matsuzawa, Keita Ishiduka, Kotaro Endo
  • Patent number: 8283286
    Abstract: A thermosensitive recording material which comprises a color forming layer comprising a color forming substance, which comprises a colorless or light color leuco dye, and a color developer and disposed on a support, wherein a mixture of (A) at least one compound selected from 4-hydroxy-4?-allyloxydiphenylsulfone, 4-hydroxy-4?-ethyloxydiphenylsulfone and 4-hydroxy-4?-n-propoxydiphenylsulfone and (B) a diphenylsulfone bridged compound represented by general formula (1): n representing an integer of 1 to 10, in amounts such that the ratio of the amounts by mass of (A) to (B) is 85:15 to 25:75 is used as the color developer. In the thermosensitive recording material, color is formed with a great density, image portions exhibit excellent properties for storage, in particular, excellent resistance to plasticizers, and portions of no color formation exhibit excellent properties for storage, in particular, excellent heat resistance.
    Type: Grant
    Filed: August 22, 2008
    Date of Patent: October 9, 2012
    Assignee: Nicca Chemical Co., Ltd.
    Inventor: Hajime Saito
  • Publication number: 20120184779
    Abstract: To provide a gelling agent containing a fluoroalkyl derivative, a small amount of which can gelatinize or solidify various organic solvents. The gelling agent for organic liquids contains a fluoroalkyl derivative represented by the following formula: wherein each of m, n and x is a positive integer.
    Type: Application
    Filed: November 21, 2008
    Publication date: July 19, 2012
    Inventors: Hiroaki Okamoto, Yuki Morita
  • Publication number: 20120141931
    Abstract: A negatively charged polymerized toner having high charging performance, which comprises a charge control agent particularly useful for color toners and polymerized toners, the charge control agent comprising a cyclic phenol sulfide as an active ingredient, which speeds up charging risetime, has a high charge amount and charging characteristics particularly excellent in environmental stability, and is safe since it does not have any problem with the waste regulations.
    Type: Application
    Filed: August 5, 2010
    Publication date: June 7, 2012
    Inventors: Masateru Yasumura, Masami Ito, Motonori Tsuji, Masataka Sawano, Kanae Hiraishi, Masaya Tojou
  • Publication number: 20120121536
    Abstract: Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells.
    Type: Application
    Filed: March 24, 2011
    Publication date: May 17, 2012
    Applicant: OHIO UNIVERSITY
    Inventors: Xiaozhuo Chen, Stephen Bergmeier
  • Publication number: 20120077885
    Abstract: A compound represented by the following formula (1) is provided as a gelling agent for gelatinizing a liquid organic compound: wherein n and m are each independently an integer of 2 to 18, R1 and R3 are each independently a single bond or a branched or linear alkylene group having 1 to 6 carbon atoms, R2 is a branched or linear alkylene group having 3 to 18 carbon atoms, and Z1 and Z2 are each independently a phenylene group or a biphenylene group.
    Type: Application
    Filed: May 31, 2010
    Publication date: March 29, 2012
    Inventors: Hiroaki Okamoto, Yuki Morita
  • Publication number: 20120053180
    Abstract: This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human health causing various complications (blindness, kidney failure, neuropathy, heart attack, stroke, etc.). Recently it was found that activation of GPR119 which is highly expressed in pancreatic beta cells causes glucose dependent insulin secretion and GLP-1 release. Many pharmaceuticals are currently developing GPR119 agonists and herein we disclose alternative GPR119 agonists. Our invention describes GPR119 agonists having structural Formula (I), pharmaceutically acceptable salt or solvate of Formula (I), isomer or prodrug of Formula (I), and combination therapy of Formula (I) with other anti-diabetic drugs like DPP-IV inhibitors and/or insulin sensitizers.
    Type: Application
    Filed: March 17, 2011
    Publication date: March 1, 2012
    Applicant: CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
    Inventors: Sang Uk Kang, Min Jeong Kim, Byung Nam Kang, Wei Tan, Albert Charles Gyorkos, Suk Young Cho
  • Publication number: 20120034176
    Abstract: The present invention relates to a compound of the general formula (I) where: X?S, SO or SO2; and one of the radicals R1 and R2 is a hydrogen atom and the other is a radical: a C1 to C18 linear or branched alkyl, optionally substituted by one or more halogen atom(s); a C2 to C18 linear or branched alkenyl, optionally substituted by one or more halogen atom(s); an aralkyl, optionally substituted by one or more C1 to C6alkoxy group(s); or a COR3 or CONHR3, but not simultaneously, where R3 is a radical: a C1 to C18 linear or branched alkyl, optionally substituted by one or more halogen atom(s); a C2 to C18 linear or branched alkenyl, optionally substituted by one or more halogen atom(s); an aralkyl, optionally substituted by one or more C1 to C6alkoxy group(s); an aralkenyl, optionally substituted by one or more C1 to C6 alkoxy groups and/or one or more OH group(s); or an aryl radical, optionally substituted by one or more C1 to C6 alkoxy group(s).
    Type: Application
    Filed: April 8, 2010
    Publication date: February 9, 2012
    Applicant: PIERRE FABRE DERMO-COSMETIQUE
    Inventor: Stéphane Poigny
  • Publication number: 20120009480
    Abstract: The electrolyte solution for a lithium ion secondary battery according to the present invention contains a nonaqueous solvent, a lithium salt and a compound represented by the general formula (Z) shown below. Thereby, a lithium ion secondary battery having high battery characteristics and simultaneously achieving a high safety as well can be provided. R—SO2—Ar1—O—R1??(Z) wherein Ar1 denotes a substituted or nonsubstituted divalent aromatic group having 5 to 30 atoms of the nucleus(es); R1 denotes a saturated or unsaturated monovalent hydrocarbon group having 1 to 20 carbon atoms; and R denotes a saturated or unsaturated monovalent hydrocarbon group having a perfluoroalkyl group and having 2 to 22 carbon atoms.
    Type: Application
    Filed: August 8, 2011
    Publication date: January 12, 2012
    Applicants: YAMAGUCHI UNIVERSITY, ASAHI KASEI E-MATERIALS CORPORATION
    Inventors: Asami OHASHI, Yoshiyuki ISHII, Hiroaki OKAMOTO, Yuki MORITA
  • Publication number: 20110281898
    Abstract: The invention relates to substituted phenoxyacetic acids as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
    Type: Application
    Filed: July 26, 2011
    Publication date: November 17, 2011
    Inventors: Roger Victor Bonnert, Anil Patel, Stephen Thom
  • Publication number: 20110269985
    Abstract: Compounds having stable isotopes 13C and/or 2H were synthesized from precursor compositions having solid phase supports or affinity tags.
    Type: Application
    Filed: June 2, 2011
    Publication date: November 3, 2011
    Applicant: Los Alamos National Security, LLC
    Inventors: Jurgen G. Schmidt, David B. Kimball, Marc A. Alvarez, Robert F. Williams, Rudolfo A. Martinez
  • Publication number: 20110207967
    Abstract: Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) is defined including a step in which (i) a compound of formula (II) is reacted formula (III) wherein R is an alkyl group; LG is a leaving group; m is an integer from 0 to 8; n is an integer of from 0 to 9; and X is hydrogen, halide, hydroxyl or protected hydroxyl; in the presence of a copper, nickel or palladium catalyst.
    Type: Application
    Filed: September 24, 2009
    Publication date: August 25, 2011
    Inventors: Lars Skattebol, Inger Aukrust, Marcel Sandberg
  • Publication number: 20110136664
    Abstract: Diphenylsulfone bridged compounds of the general formula: (1) wherein n is an integer of 1 to 10. Further, there is disclosed a thermal recording material comprising a support and, superimposed thereon, a thermosensitive color forming layer containing a color forming substance for thermal recording consisting of any of the diphenylsulfone bridged compounds and a color forming substance consisting of a colorless or light-colored leuco dye. This thermal recording material excels in the storability, especially wet heat resistance and oil resistance, of image areas and further exhibits excellent characteristics in the storability, especially heat resistance, of undeveloped areas.
    Type: Application
    Filed: July 28, 2008
    Publication date: June 9, 2011
    Applicant: NICCA CHEMICAL CO., LTD.
    Inventors: Hajime Saito, Takeo Hasegawa
  • Publication number: 20110120345
    Abstract: Provided is a color-developing composition containing a molecular compound which has as a component compound a compound represented by formula (I) [wherein Y represents a C1-C12 hydrocarbon group which is chained or branched and saturated or unsaturated, or a C1-C8 hydrocarbon group which is chained or branched, saturated or unsaturated and has an ether or thioether bond; R1, R2, R3 and R4 each independently represent a C1-C6 alkyl group or C2-C6 alkenyl group; n, p, q and r each represents any integer of 0 to 4; and m represents any integer of 0 to 2]. Also provided is a recording material with a sufficient color-forming sensitivity, superior storage stability, and especially with an extremely little background fogging in a heat resistance test.
    Type: Application
    Filed: August 3, 2009
    Publication date: May 26, 2011
    Applicant: NIPPON SODA CO., LTD.
    Inventors: Satoshi Kodama, Kazumi Jyujyo
  • Publication number: 20110082176
    Abstract: The present disclosure provides non-naturally occurring polyphenol compounds that upregulate the expression of Apolipoprotein A-I (ApoA-I). The disclosed compositions and methods can be used for treatment and prevention of cardiovascular disease and related disease states, including cholesterol or lipid related disorders, such as, e.g., atherosclerosis.
    Type: Application
    Filed: October 15, 2010
    Publication date: April 7, 2011
    Inventors: Norman C.W. Wong, Joseph E.L. Tucker, Henrik C. Hansen, Fabrizio S. Chiacchia, David McCaffrey
  • Publication number: 20110045973
    Abstract: Provided is a color-developing composition for recording materials having a superior heat resistance. The color-developing composition is a reaction composition containing a mixture of compounds represented by formula (III) obtained by reacting a dihydroxydiphenylsulfone derivative represented by formula (I) with a dihalide represented by formula (II) X-Y-X (II), wherein, in a composition where the content of a compound with n=1 in said reaction composition is from 5 to 80% by mass of the total solid content of the composition, at least 10% by mass of the compound with n=1 is a crystalline material.
    Type: Application
    Filed: May 1, 2009
    Publication date: February 24, 2011
    Applicant: Nippon Soda Ltd.
    Inventors: Satashi Kodama, Toshiyuki Fukami, Hiroshi Fujii, Tadashi Kawakami, Toshio Aihara
  • Publication number: 20110039874
    Abstract: Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 17, 2011
    Applicant: Northeastern University
    Inventors: Alexandros Makriyannis, Spyridon P. Nikas, Shakiru O. Alapafuja, Vidyanand G. Shukla
  • Publication number: 20110004006
    Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 6, 2011
    Applicant: CARDIOME PHARMA CORP.
    Inventors: Grace Jung, Bertrand M. C. Plouvier, Yuzhong Liu, Jeff Jiqun Zhu, Tao Sheng, Anthony G. M. Barrett, Lewis Siu Leung Choi, Doug Ta Hung Chou
  • Patent number: 7833690
    Abstract: The present invention relates to photoacid generating compounds, lithographic resists comprising photoacid generating compounds, and to various lithographic processes techniques, and applications.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: November 16, 2010
    Assignee: The University of North Carolina at Charlotte
    Inventors: Kenneth E. Gonsalves, Mingxing Wang
  • Publication number: 20100174104
    Abstract: Asymmetric cyclopropanation of olefins with diazosulfones.
    Type: Application
    Filed: March 16, 2009
    Publication date: July 8, 2010
    Inventors: X. Peter Zhang, Shifa Zhu
  • Publication number: 20100105953
    Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
    Type: Application
    Filed: October 23, 2009
    Publication date: April 29, 2010
    Applicant: Symphony Evolution, Inc.
    Inventors: Lynne Canne Bannen, Erick W. Co, Vasu Jammalamadaka, John M. Nuss, Moon Hwan Kim, Donna Tra Le, Amy Lew, Morrison B. Mac, Shumeye Mamo, Zhaoyang Wen, Wei Xu, Richard George Khoury
  • Patent number: 7682772
    Abstract: A compound represented by general formula (I); and a compound represented by general formula (b1-1). [Chemical Formula 1] X-Q1-Y1—SO3?M+??(I) X-Q1-Y1—SO3?A+??(b1-1) wherein Q1 represents a divalent linkage group or a single bond; Y1 represents an alkylene group which may have a substituent or a fluorinated alkylene group which may have a substituent; X represents a cyclic group of 3 to 30 carbon atoms which may have a substituent, and has an —SO2— bond in the structure thereof; M+ represents an alkali metal ion; and A+ represents an organic cation.
    Type: Grant
    Filed: November 5, 2008
    Date of Patent: March 23, 2010
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Takehiro Seshimo, Yoshiyuki Utsumi, Akiya Kawaue, Hideo Hada, Hiroaki Shimizu, Tsuyoshi Nakamura
  • Publication number: 20090325972
    Abstract: Disclosed herein are a novel cinnamaldehyde compound represented by Chemical Formula 1 or pharmaceutically acceptable salts thereof. The cinnamaldehyde compound has improved solubility in water and has inhibitory effects on the growth of cancer cells because it induces cell cycle arrest and cell death. Also disclosed are a method of preparing the cinnamaldehyde compound and an anticancer composition including the compound of Chemical Formula 1.
    Type: Application
    Filed: August 28, 2008
    Publication date: December 31, 2009
    Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
    Inventors: Byoung Mog KWON, Dong Cho HAN, Hye Nan KIM, Young Min HAN, Dae Seop SHIN, Yeong Rim Kang
  • Publication number: 20090306016
    Abstract: Disclosed are compounds of formula R—X—Y that may be used to inhibit the action of fatty acid amide hydrolase (FAAH). Inhibition of fatty acid amide hydrolase (FAAH) will slow the normal degradation and inactivation of endogenous cannabinoid ligands by FAAH hydrolysis and allow higher levels of those endogenous cannabinergic ligands to remain present. These higher levels of endocannabinoid ligands provide increased stimulation of the cannabinoid CB1i and CB2 receptors and produce physiological effects related to the activation of the cannabinoid receptors. They will also enhance the effects of other exogenous cannabinergic ligands and allow them to produce their effects at lower concentrations as compared to systems in which fatty acid amide hydrolase (FAAH) action is hot inhibited. Thus, a compound that inhibits the inactivation of endogenous cannabinoid ligands by fatty acid amide hydrolase (FAAH) may increase the levels of endocannabinoids and, thus, enhance the activation of cannabinoid receptors.
    Type: Application
    Filed: July 27, 2007
    Publication date: December 10, 2009
    Inventors: Alexandros Makriyannis, Spyridon P. Nikas, Shakiru O. Alapafuja, Vidyanand G. Shukla
  • Patent number: 7619120
    Abstract: The present invention is to provide methods for producing highly pure 4,4?-dihydroxydiphenyl sulfone monoethers advantageously in industrial production. In a process for producing a compound represented by Formula (I) (wherein, R1 and R2 are each independently halogen, alkyl having 1 to 8 carbons or alkenyl having 2 to 8 carbons; m and n are each independently 0 or an integer of 1 to 4; and R3 is alkyl having 1 to 8 carbons, alkenyl having 2 to 8 carbons, cycloalkyl having 3 to 8 carbons or optionally substituted aralkyl), (1) a pH adjustment is carried out twice or more in the purification process, (2) an excessive amount of alkyl halide used is removed, (3) a solvent, such as water, containing 0.05 ppm or less of iron components is used, (4) tanks with corrosion-resistant layers over the inner walls are used, (6) a chelating agent is added, and (7) a means of drying with mechanical stir is applied.
    Type: Grant
    Filed: September 27, 2004
    Date of Patent: November 17, 2009
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Kiyoshi Katsuura, Tomoya Hidaka, Yutaka Takashina, Yasuo Ohnuki
  • Publication number: 20090176995
    Abstract: Disclosed are soluble diarylmethanofullerene derivatives that are effective as acceptors for organic thin-film solar batteries. They help to constitute effective organic thin-film solar batteries.
    Type: Application
    Filed: November 28, 2008
    Publication date: July 9, 2009
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY
    Inventors: Takeshi Toru, Norio Shibata, Shuichi Nakamura, Tetsuo Soga, Yasuhiko Hayashi, Surya Prakash Singh
  • Publication number: 20080318923
    Abstract: It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.
    Type: Application
    Filed: January 30, 2006
    Publication date: December 25, 2008
    Applicant: TAISHO PHARMACEUTICAL CO., LTD.
    Inventors: Yoshinori Sekiguchi, Takeshi Kuwada, Masato Hayashi, Dai Nozawa, Yuri Amada, Tsuyoshi Shibata, Shuji Yamamoto, Hiroshi Ohta, Taketoshi Okubo, Takeshi Koami
  • Publication number: 20080290022
    Abstract: The invention relates to the preparation of a crosslinked polymeric film bearing ionic groupings. The process consists in extruding a material comprising at least one prepolymer, in polymerizing said material after extrusion, and in subjecting the extruded material to a chemical reaction for grafting ionic groupings. The prepolymer comprises repeating units each comprising at least one aromatic group GA and at least one functional group GF; it bears at least one group GP which is polymerizable thermally at a temperature greater than the extrusion temperature, or photochemically, and also at least one reactive group GR which allows the grafting of ionic groupings. The films are useful as a membrane for fuel cells or electrodialysis, as an electrolyte of a lithium battery, of a supercapacitor or of an electrochromic device, or as an ion exchange membrane.
    Type: Application
    Filed: November 21, 2006
    Publication date: November 27, 2008
    Inventors: Jean-Yves Sanchez, Cristina Iojoiu, Regis Mercier, Nadia El Kissi, France Chabert, Jeremie Salomon
  • Patent number: 7419623
    Abstract: An electrochemical device and a proton conducting medium for use in an electrochemical device having a proton conducting electrolyte comprising the formula: HaMbQ.nH2O where H is a proton, M is a cation, Q is the fluoroborate or fluoroheteroborate anion, n ranges from 0.01 to 1000, a ranges from 0.01 to 2 and b ranges from 0 to 2, a and b are chosen to render the formula electrically neutral, and when b is greater than 0, the ratio of b to a is less than 100 to 1.
    Type: Grant
    Filed: August 3, 2004
    Date of Patent: September 2, 2008
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Sergei Vladimirovich Ivanov, William Jack Casteel, Jr., Guido Peter Pez
  • Publication number: 20080200702
    Abstract: The present invention relates to an improved process for the preparation of Coenzyme Q. Coenzyme Q10 or CoQ10 has the chemical name 2-[(all-trans)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl]-5,6-dimethoxy-3-methyl-1,4-benzoquinone and has the formula I. The invention also provides new intermediates useful for the preparation of CoQ10 and processes for their preparation.
    Type: Application
    Filed: June 21, 2006
    Publication date: August 21, 2008
    Applicant: NICHOLAS PIRAMAL INDIA LIMITED
    Inventors: Palanivelu Gurumurthy, Suneel Manohar Babu Chennamsettyl, Vaithyanathan Visweswaran
  • Patent number: 7332621
    Abstract: The present invention relates to a process for preparing Tamsulosin, an anti-benign prostatic hyperplasia drug, which comprises converting o-ethoxyphenoxyethanol to a corresponding sulfonate, and reacting the sulfonate with (R)-(?)-5-(2-aminopropyl)-2-methoxybenzenesulfonamide by condensation to produce Tamsulosin.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: February 19, 2008
    Assignee: Scinopharm Taiwan Ktd.
    Inventor: Meihua Xie
  • Patent number: 7241924
    Abstract: A process for producing 4-isopropoxy-4?-hydroxydiphenyl sulfone useful as the developer for leuco dyes to be used in thermosensible papers, which is excellent in productivity, economical efficiency and safety and permits the production of the compounds from constantly available raw materials. This process is improved in productivity and economical efficiency as compared with those of the prior art both by shortening the production time by the use of an isopropyl iodide, which is more reactive than isopropyl bromide which have been used in the prior art.
    Type: Grant
    Filed: May 28, 2003
    Date of Patent: July 10, 2007
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Syuichiro Sanpei, Masayuki Hanzawa, Yasuyuki Suzuki, Minoru Kaeriyama, Tomoya Hidaka, Toru Kawabe
  • Patent number: 7189880
    Abstract: A process for producing 2,4?-dihydroxydiphenylsulfone which comprises separating 4,4?-dihydroxydiphenylsulfone by crystallization from a mixture containing 4,4?-dihydroxydiphenylsulfone, 2,4?-dihydroxydiphenylsulfone, phenolsulfonic acid and phenol which is obtained by dehydration of phenol and sulfuric acid or phenolsulfonic acid to obtain a mixture having a content of 2,4?-dihydroxydiphenylsulfone greater than the content of 4,4?-dihydroxydiphenylsulfone, crystallizing 2,4?-dihydroxydiphenylsulfone by adjusting the composition of the solvent of the obtained mixture so that the ratio of the amounts by weight of phenol to water is 10:90 to 90:10, and separating 2,4?-dihydroxydiphenylsulfone by filtration; and a process as described above in which the filtrate obtained by the filtration is used as the raw material for the hydration.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: March 13, 2007
    Assignee: Nicca Chemical Co., Ltd.
    Inventors: Gou Yoshino, Yuichi Tomoda, Norihiro Taniguchi, Kazuaki Igarashi, Takeo Hasegawa
  • Patent number: 7053123
    Abstract: (E)-Styryl benzylsulfones useful as antiproliferative agents, including, for example, anticancer agents, are provided according to formula I: wherein: R1 is selected from the group consisting of halogen, C1–C6 alkoxy, nitro, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2–C6 alkoxy); and R2 and R3 are independently selected from the group consisting of halogen, C1–C6 alkoxy, C1–C6 alkyl, nitro, cyano, hydroxyl, phosphonato, amino, sulfamyl, carboxy, acetoxy, and dimethylamino (C2–C6 alkoxy); provided: R1 may not be halogen when R2 and R3 are both halogen; R2 may not be 2-halogen when R3 is 4-halogen; or a pharmaceutically acceptable salt thereof; or formula II: wherein: R4 is selected from the group consisting of C1–C6 alkoxy, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2–C6 alkoxy); R6 is selected from the group consisting of nitro, hydrogen, phosphonato, amino, sulfamyl, carboxy, acetoxy and dimethylamino (C2–C6 alkoxy); and R7 is selected from the group consistin
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: May 30, 2006
    Assignee: Temple University-of the Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Patent number: 6974886
    Abstract: The present invention provides a process for producing dihydroxydiphenylsulfone wherein trihydroxytriphenylsulfone and coloring impurities are effectively removed without altering the isomeric composition of dihydroxydiphenylsulfone. In particular, the present invention provides a process for producing dihydroxydiphenylsulfone comprising the steps of dissolveing or suspending in an aqueous solvent crude dihydroxydiphenylsulfone containing trihydroxytriphenylsulfone, adjusting the pH to 5–7, optionally cooling, and separating the crystalline dihydroxydiphenylsulfone thus precipitated.
    Type: Grant
    Filed: April 24, 2003
    Date of Patent: December 13, 2005
    Assignee: Konishi Chemical Ind. Co., Ltd.
    Inventors: Fumio Oi, Norio Yanase, Takayuki Kitahara, Nobuyuki Nate