Oxy Containing Patents (Class 568/333)
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Patent number: 11919999Abstract: Provided are a method for preparing a polyetherketoneketone and a polyetherketoneketone prepared thereby, wherein, at the time of a polymerization reaction, nitrogen gas is blown into a liquid reaction medium while stirring, thereby quickly removing hydrochloric acid, which is a by-product generated during the reaction, and preventing aggregation of resin particles, thus suppressing the generation of scales.Type: GrantFiled: November 16, 2018Date of Patent: March 5, 2024Assignee: HANWHA CHEMICAL CORPORATIONInventors: Kwang Seok Jeong, Min Sung Kim, Jae Heon Kim, Ju Young Park, Cho Hee Ahn, Byeong Hyeon Lee, Sang Hyun Cho
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Patent number: 11621406Abstract: A display apparatus includes a substrate, a display arranged on the substrate and including a plurality of display elements, and an encapsulator arranged on the display and encapsulating the display. The encapsulator may include at least one inorganic film and at least one organic film, and the at least one organic film may include a matrix and an ultraviolet light absorbent dispersed in the matrix.Type: GrantFiled: May 28, 2020Date of Patent: April 4, 2023Assignee: Samsung Display Co., Ltd.Inventors: Wonmin Yun, Yisu Kim, Eungseok Park, Byoungduk Lee, Yoonhyeung Cho, Yongchan Ju
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Patent number: 11576774Abstract: The disclosure provides insertion tools and articles that facilitate entry of a medical device, such as a balloon catheter, into the body. In embodiments the insertion tools have an elongate hollow body (50) that is able to protect a portion of a medical device, such as a balloon of a balloon catheter, during an insertion procedure. In one embodiment the insertion tool has an elongate hollow body (131), a tapered distal end (135), and a locking mechanism (133) at the proximal end which can secure a portion of a balloon catheter. An opening at the distal end can allow passage of the balloon in a folded uninflated state.Type: GrantFiled: June 29, 2020Date of Patent: February 14, 2023Assignee: Surmodics, Inc.Inventors: Bruce M. Jelle, Joram Slager, Joseph S. McGonigle, Rick Murphy, Andrew G. Bach, Teryl L. Woodwick Sides, Ambereen Angamuthu, Sean Lundquist, Gary Opperman, Nathan A. Lockwood
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Patent number: 11069865Abstract: The invention provides a flexible display panel and a fabricating method thereof. The flexible display panel includes a flexible substrate, one or more layers of a laser absorbing layer disposed in the flexible substrate, and a display functional layer disposed on the flexible substrate, the laser absorbing layer containing a fluorine-containing aromatic organic compound as an ultraviolet light absorber. The fluorine-containing aromatic organic compound used the ultraviolet light absorbing agent has strong ultraviolet light absorbing ability, and is chemically stable, and can be stably present in a flexible substrate, thereby being capable of absorbing excess laser energy in the LLO process and preventing the excess laser energy in the LLO process from further carbonizing the display functional layer on the flexible substrate. Thus, the LLO process yield of the flexible display panel is effectively improved and the yield of the product is greatly improved as a result.Type: GrantFiled: December 19, 2018Date of Patent: July 20, 2021Assignee: Wuhan China Star Optoelectronics Semiconductor Display Technology Co., Ltd.Inventor: Tianfu Guo
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Patent number: 9169216Abstract: The present invention provides a method to prepare 5-substituted pyrimidines by reacting a 5-acylpyrimidine with a suitable nucleophile to afford a 5-methanolpyrimidine, such as flurprimidol.Type: GrantFiled: March 8, 2012Date of Patent: October 27, 2015Assignee: Regents of the University of MinnesotaInventors: Robert Vince, Ashish P. Vartak
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Publication number: 20150148441Abstract: The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally, there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety, a hydrolytic stable linker and two polymerisable functional groups are incorporated into the photoinitiator structure.Type: ApplicationFiled: May 14, 2013Publication date: May 28, 2015Inventors: Niels Joergen Madsen, Petr Sehnal, David George Anderson, Bo Rud Nielsen
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Publication number: 20150060728Abstract: Described is a reagent that enhances acid generation of a photoacid generator and a composition containing such a reagent.Type: ApplicationFiled: September 3, 2014Publication date: March 5, 2015Inventors: Satoshi Enomoto, Takashi Miyazawa
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Patent number: 8952200Abstract: The disclosed technology provides a liquid crystal oligomer, a synthesis composition, a preparation method thereof, and a liquid crystal material. The liquid crystal oligomer is represented by the following chemical formula, wherein substituent R is hydrogen or methyl. In addition to a higher glass transition temperature, good heat resistance, low viscosity and a self-crosslinkable group, the liquid crystal oligomer has thermal self-crosslinking and high thermal stability of thermosetting materials.Type: GrantFiled: April 13, 2012Date of Patent: February 10, 2015Assignees: Boe Technology Group Co., Ltd., Beijing Boe Display Technology Co., Ltd.Inventors: Wei Yan, Dan Wang
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Publication number: 20150010469Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer, stereoisomer or deuterated analogue thereof, wherein X, R, R1, R2, R3, R4, M1, M2, L1, L2, J1, J2, a1, a2, b1 and b2 are as defined herein, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.Type: ApplicationFiled: July 3, 2014Publication date: January 8, 2015Applicants: British Columbia Cancer Agency Branch, University of British ColumbiaInventors: Raymond John Andersen, Javier Garcia Fernandez, Marianne Dorothy Sadar
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Publication number: 20140336258Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.Type: ApplicationFiled: July 29, 2014Publication date: November 13, 2014Inventor: Menachem Shoham
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Publication number: 20140173972Abstract: A liquid fuel composition containing (a) a gasoline base fuel suitable for use in an internal combustion engine; and (b) one or more organic sunscreen compounds. The liquid fuel composition of the present invention provides benefits in terms of improved acceleration and/or power output of an internal combustion engine fuelled by said fuel as well as an increase in flame speed.Type: ApplicationFiled: December 19, 2013Publication date: June 26, 2014Applicant: SHELL OIL COMPANYInventors: Mark Lawrence BREWER, Michael William HOWE
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Publication number: 20140064053Abstract: A two-photon absorption material that can, thanks to a compound of, for example, the following formula (6), perform non-resonant two-photon absorption by light in the region shorter than 700 nm with high sensitivity and has sufficient recording/reproduction properties, a two-photon absorption recording material, a recording medium and a two-photon absorption compound usable therein are provided.Type: ApplicationFiled: November 11, 2013Publication date: March 6, 2014Applicant: FUJIFILM CorporationInventors: Hiroaki TSUYAMA, Masaharu AKIBA, Hidehiro MOCHIZUKI, Toshio SASAKI, Tatsuo MIKAMI
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Publication number: 20130338120Abstract: The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.Type: ApplicationFiled: June 14, 2013Publication date: December 19, 2013Inventor: Shengmin Sang
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Publication number: 20130231405Abstract: An aromatic perfluoroalkane monomer is provided that can be used for the manufacture of a polymer membrane for a PEM-type fuel cell. The perfluoroalkane monomer has a structure corresponding to a formula (I): Z1—Ar3—C(O)—Ar1—(CF2)n—Ar2—C(O)—Ar4—Z2??(I) in which: n is in a range from 1 to 20; Ar1, Ar2, Ar3, Ar4 which are identical or different, represent a substituted or unsubstituted phenylene group; and Z1 and Z2, which are identical or different, represent an electrophilic or nucleophilic polymerizable functional group.Type: ApplicationFiled: July 6, 2011Publication date: September 5, 2013Applicants: MICHELIN RECHERCHE ET TECHNIQUE S.A., COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELINInventor: Milan Fedurco
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Publication number: 20130217877Abstract: The present invention discloses novel aromatic ketone compounds with functional substiution groups at para- or meta positions which can be used as photo-initiators or effective components of photo-initiator mixtures for the photopolymerizations of ethylenically unsaturated systems. The preparation of these compounds is also disclosed.Type: ApplicationFiled: November 4, 2011Publication date: August 22, 2013Applicant: SHENZHEN UV-CHEMTECH CO., LTDInventors: Yongbo Zhang, Yanchao Wang, Yapeng Wang, Huaihai Song, Zhigang Wang
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Publication number: 20130201265Abstract: The ink composition of the invention is applied to a region to which a color ink composition has been applied. The ink composition contains a weather resistance enhancer, is substantially free from a colorant, and is applied to a recording medium to form a coating film exhibiting an integrated value of light transmittance of not more than 2000 for each nanometer at wavelengths of 320 nm to 360 nm and an integrated value of light transmittance of not less than 36000 for each nanometer at wavelengths of 380 nm to 780 nm.Type: ApplicationFiled: February 6, 2013Publication date: August 8, 2013Applicant: SEIKO EPSON CORPORATIONInventor: Seiko Epson Corporation
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Patent number: 8450495Abstract: A method of preparing novel [11C]-labeled benzophenone/bezoxazole analogues is provided. The present invention also provides novel [11C]-labeled benzophenone/bezoxazole analogues prepared from the GMP synthesis method. Kit claims for preparing novel [11C]-labeled benzophenone/bezoxazole analogues and a method of use thereof are also provided.Type: GrantFiled: September 11, 2012Date of Patent: May 28, 2013Assignee: GE Healthcare LimitedInventors: Farhad Karimi, Bengt Langstrom
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Publication number: 20130131182Abstract: The present invention relates to chemical total synthesis methods of six novel protein tyrosine phosphatase-1B (PTP1B) inhibitors and application of the inhibitors in the preparation of medicaments for treating type 2 diabetes mellitus (T2DM). The PTP1B inhibitors use one or more of the six compounds represented by the structural formulae 1, 2, 3, 4, 5 and 6, as active components. The compounds can enhance the sensitivity of an insulin receptor by inhibiting the activity of PTP1B, thereby having a favorable therapeutic effect on insulin-resistant T2DM.Type: ApplicationFiled: July 7, 2011Publication date: May 23, 2013Applicant: INSTITUTE OF OCEANOLOGY, CHINESE ACADEMY OF SCIENCESInventors: Dayong Shi, Shuju Guo, Xiao Fan, Weishen Lu, Yongchao Cui
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Publication number: 20130109758Abstract: This invention provides compounds having a structure of Formula (I). Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.Type: ApplicationFiled: January 6, 2011Publication date: May 2, 2013Applicants: THE UNIVERSITY OF BRITISH COLUMBIA, BRITISH COLUMBIA CANCER AGENCY BRANCHInventors: Marianne D. Sadar, Nasrin R. Mawji, Carmen Adriana Banuelos, Raymond J. Andersen, Javier Garcia Fernandez
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Patent number: 8389769Abstract: A polymerizable Type II photoinitiator according to Formula (I): wherein: A represents a Norrish Type II initiating group; L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-8 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 8 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: GrantFiled: May 28, 2009Date of Patent: March 5, 2013Assignee: Agfa Graphics NVInventors: Johan Loccufier, Jaymes Van Luppen
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Patent number: 8350090Abstract: The present invention provides novel processes of preparing racemic and optically active cyclopentenones of Formula I: The invention also provides novel cyclopentenones of formula I in racemic or optically active form.Type: GrantFiled: August 24, 2011Date of Patent: January 8, 2013Assignee: Chirogate International Inc.Inventors: Shih-Yi Wei, Wan-Chun Chang, Yu-Chih Yeh
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Publication number: 20130005984Abstract: A method of preparing novel [11C]-labeled benzophenone/bezoxazole analogues is provided. The present invention also provides novel [11C]-labeled benzophenone/bezoxazole analogues prepared from the GMP synthesis method. Kit claims for preparing novel [11C]-labeled benzophenone/bezoxazole analogues and a method of use thereof are also provided.Type: ApplicationFiled: September 11, 2012Publication date: January 3, 2013Applicant: GE HEALTHCARE LIMITEDInventors: FARHAD KARIMI, BENGT LANGSTROM
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Publication number: 20120330052Abstract: The present invention relates to a conjugated aromatic compound represented by the Formula (1) in claim 1 (in the formula, Ar1 represents a hydrogen atom or an aryl group optionally having a substituent; Ar2 and Ar3 each represent a hydrogen atom or an aryl group optionally having a substituent but at least one of Ar2 and Ar3 represents an aryl group optionally having a substituent; and A represents an aromatic hydrocarbon group) and relates to an optical material containing the conjugated aromatic compound. The conjugated aromatic compound and the optical material have characteristics of a high chromatic aberration correction function, high refractive-index dispersion characteristics (Abbe number (vd)) and high secondary dispersion characteristics (?g,F) (anomalous dispersion characteristics).Type: ApplicationFiled: March 14, 2011Publication date: December 27, 2012Applicant: CANON KABUSHIKI KAISHAInventor: Terunobu Saitoh
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Patent number: 8309770Abstract: A method of preparing novel [11C]-labeled benzophenone/bezoxazole analogues is provided. The present invention also provides novel [11C]-labeled benzophenone/bezoxazole analogues prepared from the GMP synthesis method. Kit claims for preparing novel [11C]-labeled benzophenone/bezoxazole analogues and a method of use thereof are also provided.Type: GrantFiled: May 21, 2007Date of Patent: November 13, 2012Assignee: GE Healthcare LimitedInventors: Farhad Karimi, Bengt Langstrom
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Publication number: 20120264980Abstract: The disclosed technology provides a liquid crystal oligomer, a synthesis composition, a preparation method thereof, and a liquid crystal material. The liquid crystal oligomer is represented by the following chemical formula, wherein substituent R is hydrogen or methyl. In addition to a higher glass transition temperature, good heat resistance, low viscosity and a self-crosslinkable group, the liquid crystal oligomer has thermal self-crosslinking and high thermal stability of thermosetting materials.Type: ApplicationFiled: April 13, 2012Publication date: October 18, 2012Applicants: BEIJING BOE DISPLAY TECHNOLOGY CO., LTD, BOE TECHNOLOGY GROUP CO., LTD.Inventors: Wei YAN, Dan WANG
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Publication number: 20110257112Abstract: The invention concerns compounds DLBS1425E2.2 and DLBS1425F1 isolated and identified from the extract of the plant Phaleria macrocarpa (Scheff.) Boerl. The invention also relates to the use of said compounds, either as a single active compound or in combination, in a pharmaceutical dosage form that has anti-proliferative activity of cancer cells, and its use relating to female related diseases. Formula (I).Type: ApplicationFiled: November 26, 2009Publication date: October 20, 2011Inventors: Asep Aripin, Poppy Firzani Arifin, Raymond R. Tjandrawinata
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Publication number: 20110140043Abstract: The present invention relates to the compounds of the formula (1) and to organic electronic devices in which these compounds are used as matrix material in the emitting layer and/or as hole-transport material and/or as electron-blocking or exciton-blocking material and/or as electron-transport material.Type: ApplicationFiled: June 19, 2009Publication date: June 16, 2011Applicant: MERCK PATENT GMBHInventors: Philipp Stoessel, Holger Heil, Dominik Joosten, Christof Pflumm, Anja Gerhard, Arne Buesing, Joachim Kaiser
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Patent number: 7943803Abstract: A clathrate compound containing a polymolecular host compound as a host compound and an agricultural chemical active ingredient having a saturated solubility in water at 25° C. of not less than 500 ppm as a guest compound.Type: GrantFiled: May 4, 2010Date of Patent: May 17, 2011Assignee: Nippon Soda Co., Ltd.Inventors: Natsuki Amanokura, Tetsuya Sahara, Hiroshi Suzuki, Yuichi Maekawa, Kiyoshi Katsuura, Yoshihiro Enomoto
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Publication number: 20110063388Abstract: A polymerizable Type II photoinitiator according to Formula (I): wherein: A represents a Norrish Type II initiating group; L represents a divalent linking group positioning the Norrish Type II initiating group A and the CR2R3-group in a 1-5 to a 1-8 position wherein position 1 is defined as the first atom in the aromatic or alicyclic ring of A to which L is covalently bonded and the position 5 to 8 is defined as the carbon atom of the CR2R3-group to which L is covalently bonded, with the proviso that L does not contain an amine. Radiation curable compositions and inks include the multifunctional Type II photoinitiator.Type: ApplicationFiled: May 28, 2009Publication date: March 17, 2011Applicant: AGFA GRAPHICS NVInventors: Johan Loccufier, Jaymes Van Luppen
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Publication number: 20100174042Abstract: Sulfonated polymers have excellent processability and methanol resistance.Type: ApplicationFiled: April 24, 2007Publication date: July 8, 2010Applicant: JSR CORPORATIONInventors: Yoshitaka Yamakawa, Yousuke Konno, Teruhiko Umehara
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Publication number: 20100137484Abstract: Disclosed is a compound having high optical anisotropy and high compatibility with a polymer resin, which is represented by Formula 1 and necessarily has at least one meta substituent. Also, a resin composition including the compound and a polymer resin, and an optical member including the resin composition are disclosed. Since the compound represented by Formula 1 is an anisotropic compound having high compatibility with a polymer resin and high optical anisotropy, in the case of an optical member obtained by using a polymer resin composition including the compound represented by Formula 1, there is no phase separation, and it is possible to achieve a required optical characteristic with only a small amount thereof.Type: ApplicationFiled: June 4, 2008Publication date: June 3, 2010Inventors: Jaeho Cheong, Minjin Ko, Kiyoul Lee, Bumgyu Chio, Myungsun Moon, Daeho Kang, YunBong Kim
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Patent number: 7709545Abstract: Benzophenone/thioxanthone derivatives useful as photoinitiators are provided as well as photopolymerizable compositions comprising the benzophenone/thioxanthone derivatives.Type: GrantFiled: December 5, 2007Date of Patent: May 4, 2010Assignee: The University of Southern MississippiInventors: Charles E. Hoyle, Sukhendu B. Hait, Mahmood Sabahi
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Publication number: 20100063298Abstract: A method of preparing novel [11C]-labeled benzophenone/bezoxazole analogues is provided. The present invention also provides novel [11C]-labeled benzophenone/bezoxazole analogues prepared from the GMP synthesis method. Kit claims for preparing novel [11C]-labeled benzophenone/bezoxazole analogues and a method of use thereof are also provided.Type: ApplicationFiled: May 21, 2007Publication date: March 11, 2010Inventors: Farhad Karimi, Bengt Langstrom
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Publication number: 20090275575Abstract: Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.Type: ApplicationFiled: September 21, 2007Publication date: November 5, 2009Applicant: CHONG KUN DANG PHARMACEUTICAL CORP.Inventors: Nam-Song Choi, Young-Mi Kim, Young-Hoon Kim, Jae-Kwang Lee, In-Taek Lim, Ho-Jin Choi, Hyun-Mo Yang, Seung-Kee Moon, Soo-Jin Kim, Hyun-Jung Yu, Jae-Su Shin, Young-Min Kwon, Sung-Sook Lee, Soon-Kil Ahn
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Patent number: 7586008Abstract: The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.Type: GrantFiled: July 9, 2008Date of Patent: September 8, 2009Assignee: Abraxis Bioscience, Inc.Inventors: Chunlin Tao, Cheng Zhi Yu, Neil P. Desai, Vuong Trieu
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Patent number: 7518021Abstract: Aromatic vinyl ether compounds represented by Formula (1) or by Formula (2) wherein each R and R? is a hydrogen atom or a group represented by Formula (3) and wherein the remaining variables are as defined in the specification, provided that at least one pR in Formula (1) and at least one uR in Formula (2) is a Formula (3) group. These aromatic vinyl ether compounds are useful as, e.g., curing agents for cationic polymerization.Type: GrantFiled: October 23, 2003Date of Patent: April 14, 2009Assignee: Daicel Chemical Industries, Ltd.Inventors: Takahiro Iwahama, Tatsuya Nakano
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Publication number: 20080275100Abstract: The invention provides para substituted dialkylphenol derivatives of propofol. The invention further provides pharmaceutical compositions comprising such analogs, methods for preparing such analogs, and methods of using such analogs to induce general anesthesia, sedation, and/or hypnotic or sleep effects in a patient.Type: ApplicationFiled: July 9, 2008Publication date: November 6, 2008Applicant: ABRAXIS BIOSCIENCE, INC.Inventors: Chunlin TAO, Cheng Zhi YU, Neil P. DESAI, Vuong TRIEU
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Patent number: 7439407Abstract: Fluorinated pentacene derivatives, for example, the novel compounds tetradecafluoropentacene, 5,6,7,12,13,14-hexafluoropentacene, 5,7,12,14-tetrafluoropentacene, and 6,13-difluoropentacene, and intermediates therefor are provided. And a method of producing fluorinated pentacene derivatives and intermediates therefor is also provided. Pentacene derivatives fluorinated at desired positions of the pentacene skeleton are obtained by introducing the oxo group, hydroxyl group, or alkoxyl group into the pentacene skeleton followed by fluorination with sulfur tetrafluoride and partial defluorination using a reducing agent.Type: GrantFiled: November 2, 2004Date of Patent: October 21, 2008Assignee: Kanto Denta Kogyo Co., Ltd.Inventors: Masafumi Kobayashi, Osamu Omae, Kimitaka Ohkubo, Yuan Gao
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Patent number: 7141688Abstract: The present invention is directed to novel fluorinated dye stabilizers having both high quenching efficiency and solubility in halogenated solvents. These dye stabilizers have shown a significantly effect on improving the dye fastness in hostile photooxidation conditions.Type: GrantFiled: October 14, 2003Date of Patent: November 28, 2006Assignee: SiPix Imaging, Inc.Inventors: Kai-Chia Feng, Ying-Syi Li, Jin Yang, HongMei Zang, Haiyan Gu, Sundaravel P. Ananthavel, Rong-Chang Liang
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Patent number: 7053249Abstract: ?-diketone fluorescent tags are disclosed, particularly those enabling the use of excitation energy in the near visible or visible spectrum. In some cases, these tags allow the use of cost-effective excitation devices such as LED's. The compounds form fluorescent chelates (complexes) with lanthanide (III) rare earth metal ions (such as Eu3+). The fluorescent complex may be included in a latex microparticle, such as a styrene latex particle. Ideally, the complex has an absorption maximum ? equal to or greater than 360 nm, and the compound is characterized by a pKa<9.0. Kits and methods for detecting target molecules (e.g. immunoassays) are also disclosed. Such methods and kits typically use a ligand for binding to the target molecule and a labeling agent attached to the ligand. The fluorescent complexes described above are at least part of the labeling agent.Type: GrantFiled: October 25, 2002Date of Patent: May 30, 2006Assignee: IDEXX Laboratories, Inc.Inventors: Yerramilli Murthy, Robert H. Suva
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Patent number: 6943194Abstract: A newly discovered antineoplastic compound denominated “phenstatin” is herein described as are synthetic methods for producing phenstatin and the active prodrug thereof. Phenstatin was converted to the sodium phosphate prodrug (3d) by a dibenzylphosphite phosphorylation and subsequent hydrogenolysis sequence 3b?3c?3d. Phenstatin (3b) was found to be a potent inhibitor of tubulin polymerization and the binding of colchicine to tubulin comparable to combretastatin A-4 (1b).Type: GrantFiled: January 9, 1999Date of Patent: September 13, 2005Assignee: Arizona Board of Regents, acting for and on behalf of Arizona State UniversityInventors: George R. Pettit, Brian Toki
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Patent number: 6924390Abstract: Compounds useful as surface coating agents, including compounds of the formula: wherein X1 comprises a first photoreactive species; X2 comprises a second photoreactive species; Y comprises a nonpolymeric core molecule comprising an aromatic group; and Z comprises at least one charged group. The Y core can include an aromatic group such as a benzene radical, the charged groups Z can be independently selected from the organic acids that include sulfonic acid, carboxylic acid, and phosphoric acid, and the photoreactive species of X1 and X2 can independently be aryl ketones, such as those selected from the group acetophenone, benzophenone, anthraquinone, anthrone, and anthrone-like heterocycles, and their substituted derivatives.Type: GrantFiled: July 14, 2003Date of Patent: August 2, 2005Assignee: SurModics, Inc.Inventor: Dale G. Swan
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Patent number: 6903238Abstract: This invention provides estrogen receptor modulators of formula I, having the structure R1, R2, and R3 are as defined in the specification, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 11, 2002Date of Patent: June 7, 2005Assignee: WyethInventors: Robert E. McDevitt, Folake O. Adebi, Heather A. Harris, James C. Keith, Jr., Leo M. Albert
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Patent number: 6900356Abstract: This invention relates to novel polyhydroxy curcumins of the formula (I), wherein R and R1 may be same or different and are selected from H, OH and OCH3. This invention also includes a process for synthesising the above polyhydroxy curcumins by reacting substituted aromatic alhehydes with a diketone in the presence of boron oxide, alkyl borate and a primary or secondary amine catalyst. If desired, the resulting compounds can be deprotected by known means. These compounds are used as anti-oxidants.Type: GrantFiled: April 18, 2001Date of Patent: May 31, 2005Assignee: Laila ImpexInventors: Ganga Raju Gokaraju, Venkata Subbaraju Gottumukkala, Venkateswarlu Somepalli
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Patent number: 6777578Abstract: The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective antineoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.Type: GrantFiled: April 24, 2003Date of Patent: August 17, 2004Assignee: Arizona Board of RegentsInventors: George R. Pettit, Matthew P. Grealish
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Publication number: 20040092754Abstract: The invention relates to a method for producing 2- and 2,5-substituted derivatives of 4-(trifluoromethyl)-phenol and 4-(2-trifluoromethyl)-phenyl)-2-tetrahydropyranyl) ether and to novel derivatives. Said method is characterised in that a compound of formula (2) 4-(trifluoromethylphenyl)-2-(tetrahydropyranyl) ether is reacted with an electrophile E-X or a combination of electrophiles E-X and E-Y in the presence of a base, X and Y having the meanings given in the description.Type: ApplicationFiled: June 30, 2003Publication date: May 13, 2004Inventors: Bernd Schafer, Herve Geneste
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Publication number: 20040082815Abstract: The invention relates to benzophenones of formula (I), in which the substituents have the following meanings: X represents halogen; R1 represents hydrogen, halogen, C1-C6 alkyl, halo-C1-C2 alkyl, C1-C4 alkoxy, oxyhalomethyl or nitro, and; R2 represents hydrogen, C1-C6 alkyl, benzyl, cyclohexylmethyl or C3-C6 alkenyl. The invention also relates to the production of these benzophenones and to their use as fungicides.Type: ApplicationFiled: September 3, 2003Publication date: April 29, 2004Inventors: Thomas Grote, Andreas Gypser, Joachim Rheinheimer, Ingo Rose, Peter Schafer, Frank Schieweck, Norbert Gotz, Karl Eicken, Eberhard Ammermann, Siegfried Strathmann, Gisela Lorenz, Reinhard Stierl
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Publication number: 20030220304Abstract: The benzophenone derivative of combretastatin A-1, designated “hydroxyphenstatin”, was synthesized by compiling a protected bromobenzene and a benzaldehyde to form a benzhydrol which was subsequently oxidized to the ketone. Hydroxyphenstatin was converted to a sodium phosphate prodrug by dibenzyl phosphite phosphorylation and subsequent benzyl cleavage: Hydroxyphenstatin and the prodrugs thereof were found to be a potent inhibitor of tubulin polymerization and to demonstrate surprisingly effective anti neoplastic activity against a series of human cancer cells and murine P388 lymphocytic leukemia cells.Type: ApplicationFiled: April 24, 2003Publication date: November 27, 2003Inventors: George R. Pettit, Matthew P Grealish
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Publication number: 20030187007Abstract: The present invention is directed in part towards methods of modulating the function of protein kinases with phenol- and hydroxynaphthalene-based compounds. The methods incorporate cells that express a protein kinase. In addition, the invention describes methods of preventing and treating protein kinase-related abnormal conditions in organisms with a compound identified by the invention. Furthermore, the invention pertains to phenol- and hydroxynaphthalene-based compounds and pharmaceutical compositions comprising these compounds.Type: ApplicationFiled: May 28, 2002Publication date: October 2, 2003Inventors: Sheldon Xiaodong Cao, Pierre-Yves Bounaud, Xiaohua Chen, Hyun-Ho Chung, Sunil Kumar KC, Changhee Min, Jae Young Yang, Melissa C. Long
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Patent number: 6613806Abstract: The invention relates to method for the enhancement of the activity and/or systemicity of fungicidal compositions containing at least one benzoylbenzene of formula I wherein R1 through R7, m and n are as defined in claim 1, with the aid of one or more adjuvants selected from the group consisting of (a) alkylpolyglycosides, alkenyl succinic acid derivatives, dialkyl sulfosuccinates, polyvinylpyrrolidones, perfluoroalkyl acids derivatives, perfluoro(C3-20)alkyl esters of carboxylic acids, and mixtures thereof; (b) alkoxylated alcohols, amines or acids; (c) water-immiscible polar aprotic solvents; and to the use of such a composition as a fungicide.Type: GrantFiled: January 18, 2000Date of Patent: September 2, 2003Assignee: BASF CorporationInventors: Michael Aven, Henry Van Tuyl Cotter