Nitrogen Or Plural Sulfurs Containing Patents (Class 568/36)
  • Publication number: 20150087833
    Abstract: An alkyl phenyl sulfide derivative represented by the general formula [I] or an agriculturally acceptable salt thereof, and a pest control agent containing the derivative or the salt as an active ingredient. [in the above formula, R1 is, for example, a C1˜C6 alkyl group which is mono- or poly-substituted with halogen atom; R2 is, for example, a halogen atom or a C1˜C6 alkyl group; R3 is, for example, a hydrogen atom or a halogen atom; and R4 is, for example, a hydrogen atom or a C1˜C12 alkyl group.] The derivative or the salt has an excellent pest control effect.
    Type: Application
    Filed: April 11, 2013
    Publication date: March 26, 2015
    Applicants: IHARA CHEMICAL INDUSTRY CO., LTD., KUMIAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Kei Domon, Keiji Toriyabe, Yutaka Ogawa, Junichiro Bessho, Kei Kawamoto, Akira Watanabe, Masaaki Komatsu, Takeshi Matsuda, Seisuke Ito
  • Publication number: 20150005527
    Abstract: The present invention relates to a process for the asymmetric oxidation of nucleophilic organic compounds, particularly metal-free, with peroxide compounds in the presence of a chiral Brønsted acid catalyst. In one detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral imidodiphosphate catalyst. In another detail, the present invention relates to a process for enantioselective sulfoxidation of thiocompounds with peroxide compounds in the presence of a chiral phosphoric acid catalyst.
    Type: Application
    Filed: January 8, 2013
    Publication date: January 1, 2015
    Applicant: STUDIENGESELLSCHAFT KOHLE MBH
    Inventors: Benjamin List, Ilija Coric, Saihu Liao
  • Patent number: 8647780
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, 0, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FXI0)N—(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.
    Type: Grant
    Filed: March 7, 2011
    Date of Patent: February 11, 2014
    Assignee: Acep Inc.
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Publication number: 20130193382
    Abstract: The present invention relates to compounds of the formula (I) and to the use thereof in electronic devices. The invention furthermore relates to electronic devices, preferably organic electroluminescent devices (OLEDs), comprising one or more com-pounds of the formula (I). The invention again furthermore relates to the preparation of compounds of the formula (I) and to formulations comprising one or more compounds of the formula (I).
    Type: Application
    Filed: September 6, 2011
    Publication date: August 1, 2013
    Applicant: MERCK PATENT GmbH
    Inventors: Arne Buesing, Thomas Eberle, Irina Martynova, Teresa Mujica-Fernaud
  • Publication number: 20120220802
    Abstract: Aniline derivatives represented by formula (8) and formula (9): The aniline derivatives can be used as insecticides.
    Type: Application
    Filed: March 13, 2012
    Publication date: August 30, 2012
    Applicant: MITSUI CHEMICALS, INC.
    Inventors: Kei Yoshida, Takeo Wakita, Hiroyuki Katsuta, Akiyoshi Kai, Yutaka Chiba, Kiyoshi Takahashi, Hiroko Kato, Nobuyuki Kawahara, Michikazu Nomura, Hidenori Daido, Junji Maki, Shinichi Banba, Atsuko Kawahara
  • Publication number: 20120149940
    Abstract: 1,5-Dithiaocta-2,7-diene-5-oxide-1-yl (DODOyl) compounds and derivatives thereof, referred to collectively as DODOyl-derived compounds (DDCs), and chiral enantiomers and derivatives thereof, are described, which are integrin modulators that modulate integrin-mediated functions and/or processes. Pharmaceutical compositions containing integrin modulators and chiral enantiomers thereof, and methods for using integrin modulators and chiral enantiomers thereof are further described.
    Type: Application
    Filed: February 13, 2012
    Publication date: June 14, 2012
    Inventors: John B. Davidson, Ali S. Turgiev
  • Patent number: 8193121
    Abstract: 2-(3-Alkylthiobenzoyl)cyclohexanediones of the formula (I) are described as herbicides. In this formula (I), X, Y, R1 to R8 represent radicals such as hydrogen, organic radicals such as alkyl and alkoxy.
    Type: Grant
    Filed: July 27, 2010
    Date of Patent: June 5, 2012
    Assignee: Bayer Cropscience AG
    Inventors: Hartmut Ahrens, Andreas Almsick, Jan Dittgen, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Stefan Lehr, Dieter Feucht
  • Publication number: 20120021902
    Abstract: (4-Trifluoromethyl-3-thiobenzoyl)cyclohexanediones and use thereof as herbicides A description is given of (4-trifluoromethyl-3-thiobenzoyl)cyclohexanediones of the formula (I) and of their use as herbicides. In this formula (I), X, R1, R2, R3, and R4 are radicals such as hydrogen and organic radicals such as alkyl. A and Z are oxygen or alkylene.
    Type: Application
    Filed: July 19, 2011
    Publication date: January 26, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut AHRENS, Andreas VAN ALMSICK, Elmar GATZWEILER, Dieter FEUCHT, Isolde HÄUSER-HAHN, Stefan LEHR, Christopher Hugh ROSINGER
  • Patent number: 8058313
    Abstract: ?,?-Unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides of Formula I: wherein R1, R2, M1, M2, L, E1, E2, Q1, Q2 and n are as defined herein, are useful as anti-angiogenesis agents, as agents for treatment of age related senile dementia, and as antiproliferative agents including, for example, as anticancer agents.
    Type: Grant
    Filed: June 23, 2005
    Date of Patent: November 15, 2011
    Assignee: Temple University—Of The Commonwealth System of Higher Education
    Inventors: E. Premkumar Reddy, M. V. Ramana Reddy
  • Patent number: 8043786
    Abstract: The invention provides novel acid generators which are unproblematic in combustibility and accumulation inside the human body and can generate acids having high acidities and high boiling points and exhibiting properly short diffusion lengths in resist coating films and which permit the formation of resist patterns excellent smoothness with little dependence on the denseness of a mask pattern; sulfonic acids generated from the acid generators; sulfonyl halides useful as raw material in the synthesis of the acid generators; and radiation-sensitive resin compositions containing the acid generators. The acid generators have structures represented by the general formula (I), wherein R1 is a monovalent substituent such as alkoxycarbonyl, alkylsulfonyl, or alkoxysulfonyl; R2 to R4 are each hydrogen or alkyl; k is an integer of 0 or above; and n is an integer of 0 to 5.
    Type: Grant
    Filed: February 20, 2004
    Date of Patent: October 25, 2011
    Assignee: JSR Corporation
    Inventors: Satoshi Ebata, Yong Wang, Isao Nishimura
  • Patent number: 8017656
    Abstract: A compound given by the formula (I): has an excellent controlling activity against noxious arthropods.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: September 13, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiroyuki Miyazaki
  • Patent number: 7947831
    Abstract: Polymers grafted with a compound of formula I, wherein the general symbols are as defined within, have outstanding stability against oxidative, thermal, dynamic, light-induced and/or ozone-induced degradation.
    Type: Grant
    Filed: September 19, 2006
    Date of Patent: May 24, 2011
    Assignee: BASF SE Ludwigshafen
    Inventors: Hans-Rudolf Meier, Gerrit Knobloch, Pierre Rota-Graziosi, Samuel Evans, Paul Dubs, Michèle Gerster
  • Patent number: 7901812
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX1O)N?(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: March 8, 2011
    Assignees: ACEP Inc., Centre National de la Recherche Scientifique, Universite de Montreal
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Publication number: 20110053779
    Abstract: 2-(3-Alkylthiobenzoyl)cyclohexanediones of the formula (I) are described as herbicides. In this formula (I), X, Y, R1 to R8 represent radicals such as hydrogen, organic radicals such as alkyl and alkoxy.
    Type: Application
    Filed: July 27, 2010
    Publication date: March 3, 2011
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Hartmut AHRENS, Andreas VAN ALMSICK, Jan DITTGEN, Christopher Hugh ROSINGER, Isolde HÄEUSER-HAHN, Stefan LEHR, Dieter FEUCHT
  • Publication number: 20100099917
    Abstract: 1,5-Dithiaocta-2,7-diene-5-oxide-1-yl(DODOyl) compounds and derivatives thereof, referred to collectively as DODOyl-derived compounds (DDCs), and chiral enantiomers and derivatives thereof, are described, which are integrin modulators that modulate integrin-mediated functions and/or processes. Pharmaceutical compositions containing integrin modulators and chiral enantiomers thereof, and methods for using integrin modulators and chiral enantiomers thereof are further described.
    Type: Application
    Filed: June 5, 2009
    Publication date: April 22, 2010
    Inventors: John B. Davidson, Ali S. Turgiev
  • Patent number: 7417059
    Abstract: The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of diseases such as, cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, and septic shock.
    Type: Grant
    Filed: March 31, 2005
    Date of Patent: August 26, 2008
    Assignee: Takeda Pharmacetical Company Limited
    Inventors: Norikazu Tamura, Takashi Ichikawa, Masayuki Ii
  • Patent number: 7378194
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX1O)N?(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: May 27, 2008
    Assignees: ACEP, Inc., Centre de la Recherche Scientifique, Universite de Montreal
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Patent number: 7355081
    Abstract: The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: April 8, 2008
    Assignees: The University of North Carolina at Chapel Hill, The University of Rochester Medical Center, Androscience Corporation
    Inventors: Kuo-Hsiung Lee, Li Lin, Charles C-Y Shih, Ching-Yuan Su, Junko Ishida, Hironori Ohtsu, Hui-Kang Wang, Hideji Itokawa, Chawnshang Chang
  • Patent number: 7345188
    Abstract: The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetate is prepared in high yield and purity by the reaction of a haloacetate with the reaction product of thiourea and benzhydrol. The reaction employing the haloacetate is conducted in a solvent comprising an organic solvent such as methanol having dissolved therein an organic base or an inorganic basic salt such as sodium bicarbonate. The resulting benzhydrylthioacetate can be amidated and then oxidized to provide the pharmaceutical grade modafinil in high yield and purity.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: March 18, 2008
    Assignee: Mallinckrodt Inc.
    Inventor: Sidney Liang
  • Patent number: 7338958
    Abstract: This invention relates to pyrimidine derivatives of general formula I in which Q, R1, R2, R3, R4, R5, X, and m have the meanings that are contained in the description, as inhibitors of cyclin-dependent kinases and VEGF-receptor tyrosine kinases, their production as well as their use as medications for treatment of various diseases.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: March 4, 2008
    Assignee: Schering AG
    Inventors: Ulrich Luecking, Gerhard Siemeister, Martin Krueger, Rolf Jautelat
  • Patent number: 6927309
    Abstract: The invention aims at providing novel sulfur compounds, molecular compounds containing the same as the component compound, and so on. The above aim is achieved by using sulfur compounds of the general formula (I) wherein Rs are each independently hydrogen, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted aryl, chloro, or bromo; m is an integer of 0, 1, or 2; and Z is a group represented by any of the general formulae (II) to (V) (wherein R and m are each as defined above; W is hydrogen or C1-6 alkyl; and Y is a direct bond, C1-3 alkylene, or phenylene).
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: August 9, 2005
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Ryu Sato, Hiroshi Suzuki
  • Patent number: 6841304
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX1O)N?(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: January 11, 2005
    Assignees: ACEP, Inc., Centre National de la Recherche Scientifique, Universite de Montreal
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Patent number: 6692893
    Abstract: Onium salts of arylsulfonyloxynaphthalenesulfonate anions with iodonium or sulfonium cations are novel. A chemically amplified resist composition comprising the onium salt as a photoacid generator is suited for microfabrication, especially by deep UV lithography because of many advantages including improved resolution, improved focal latitude, minimized line width variation or shape degradation even on long-term PED, minimized debris after coating, development and peeling, and improved pattern profile after development.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: February 17, 2004
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Youichi Ohsawa, Jun Watanabe, Takeshi Nagata, Jun Hatakeyama
  • Patent number: 6608233
    Abstract: The present invention relates to a process for producing a bis(4-hydroxy-3-nitrophenyl) compounds, characterized by nitrating a bis(4-hydroxyphenyl) compound wherein two phenyl groups are bonded to each other directly or through an electron-donating bridging group, sulfoxide group, sulfone group or carbonyl group in an inert solvent using nitric acid under the condition of substantially free from any other acid. According to the process, the target compounds reduced in the content of trinitrates can be produced in high yield and further recrystallizing the compound easily gives in high yield a high-purity products suitable for use as a raw material of producing a heat-resistant polymer and so on because the content of a trinitro-substitued compound in that compound is low.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: August 19, 2003
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Eiichi Tanaka, Masaki Fujimoto
  • Patent number: 6489511
    Abstract: Disclosed is a process for forming an azomethine compound, comprising: (a) reacting a compound “A” having an active methylene group or methine group with an arylprimaryamine compound “B”; (b) in the presence of a base and an oxidizing agent and in a solvent medium containing a ketone compound having the formula R1C(O)R2 wherein R1 and R2 are independently C1-C4 alkyl groups; (c) at a temperature low enough to provide a yield of the azomethine product of at least 50 mole % based on compound A.
    Type: Grant
    Filed: August 16, 2001
    Date of Patent: December 3, 2002
    Assignee: Eastman Kodak Company
    Inventor: Garry D. Jones
  • Patent number: 6486351
    Abstract: The invention concerns a method for the condensation of aromatic derivative(s) or a sulphinic derivative by a perhalogenated, advantageously perfluorinated, carbon atom. Said method is characterized in that it consists in subjecting said sulphinic derivative and said aromatic derivative to the action of a strong acid whereof the pKa is not more that 0. The invention is applicable to organic synthesis.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: November 26, 2002
    Assignee: Rhodia Chimie
    Inventors: Laurent Saint-Jalmes, Marc Tordeux, Claude Wakselman
  • Publication number: 20020068765
    Abstract: This invention describes the new benzocycloheptenes of general formula I 1
    Type: Application
    Filed: July 19, 1999
    Publication date: June 6, 2002
    Inventors: ROLF BOHLMANN, JORG KROLL, HERMANN KUENZER, CHRISTA HEGELE-HARTUNG, MONIKA LESSL, ROSEMARIE LICHTNER, YUKISHIGE NISHINO
  • Publication number: 20020055045
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX1O)N−(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalised, and can be used, inter alia, as electrolyte.
    Type: Application
    Filed: November 9, 2001
    Publication date: May 9, 2002
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Patent number: 6365301
    Abstract: The invention concerns novel ionic compounds with low melting point whereof the onium type cation having at least a heteroatom such as N, O, S or P bearing the positive charge and whereof the anion includes, wholly or partially, at least an ion imidide such as (FX1O)N−(OX2F) wherein X1 and X2 are identical or different and comprise SO or PF, and their use as solvent in electrochemical devices. Said composition comprises a salt wherein the anionic charge is delocalized, and can be used, inter alia, as electrolyte.
    Type: Grant
    Filed: September 7, 1999
    Date of Patent: April 2, 2002
    Assignees: ACEP, Inc., Centre National de la Recherche Scientifique, Universite de Montreal
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Nathalie Ravet
  • Patent number: 6350545
    Abstract: Novel sulfonylinide and sulfonylmethide compounds are described which are useful as conductive salts. Also described is the use of the above compounds in salt form in battery electrolytes, particular salts having mixed perfluorocaron and hydrocarbon groups or having all hydrocarbon groups. The above salts are less expensive to produce and still exhibit excellent conductivity and low corrosivity.
    Type: Grant
    Filed: August 25, 1998
    Date of Patent: February 26, 2002
    Assignee: 3M Innovative Properties Company
    Inventors: Alan David Fanta, Phat tan Pham, Steven Joseph Hamrock
  • Publication number: 20020009650
    Abstract: The invention concerns ionic compounds in which the anionic load has been delocalized. A compound disclosed by the invention is comprised of an amide or one of its salts, including an anionic portion combined with at least one cationic portion M+m in sufficient numbers to ensure overall electronic neutrality; the compound is further comprised of M as a hydroxonium, a nitrosonium NO+, an ammonium —NH4+, a metallic cation with the valence m, an organic cation with the valence m, or an organometallic cation with the valence m. The anionic portion matches the formula RF—SOx—N−Z, wherein RF is a perfluorinated group, x is 1 or 2, and Z is an electroattractive substituent. The compounds can be used notably for ionic conducting materials, electronic conducting materials, colorants, and the catalysis of various chemical reactions.
    Type: Application
    Filed: May 16, 2001
    Publication date: January 24, 2002
    Inventors: Christophe Michot, Michel Armand, Michel Gauthier, Yves Choquette
  • Patent number: 5902905
    Abstract: There is provided a method for producing arylvinylsulfone of the formula: ##STR1## wherein, R.sup.1 and R.sup.2 denote each independently a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group,a nitro group, an amino group, a lower alkylamino group anda lower di(alkylamino) group,which comprises reacting .beta.-haloethylarylsulfone of the formula: ##STR2## wherein, R.sup.1 and R.sup.2 are as defined above and X denotes a halogen atom, with an alkali metal carbonate or an alkali metal hydrogencarbonate in the presence of a catalytic amount of an amine or its inorganic acid salt or a quaternary ammonium salt.
    Type: Grant
    Filed: November 12, 1997
    Date of Patent: May 11, 1999
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Shinzo Seko, Akio Kurihara, Isao Kurimoto
  • Patent number: 5789413
    Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: August 4, 1998
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Cameron Black, Erich Grimm, Serge Leger, Greg Hughes, Petpiboon Prasit, Zhaoyin Wang
  • Patent number: 5717083
    Abstract: Compounds are provided having structure (I), wherein the L groups are backbone segments, the Y and T groups are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds and wherein the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidation step or during a coupling step.
    Type: Grant
    Filed: August 19, 1996
    Date of Patent: February 10, 1998
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip Dan Cook, Oscar Acevedo, Normand Hebert
  • Patent number: 5675039
    Abstract: Disclosed are bis-meta-benzotrifluoride compounds having the general formula ##STR1## where each A is independently selected from the group consisting of NO.sub.2, NH.sub.2, and NH.sub.3.sup.+ Z.sup.-, Z.sup.- is an anion and B is selected from the group consisting of O, CO, S, SO, and SO.sub.2. The diamine compounds are useful as monomers in making polyimides, polyamide-imides, and polyamides.
    Type: Grant
    Filed: April 15, 1996
    Date of Patent: October 7, 1997
    Inventors: Jeffrey S. Stults, Henry C. Lin, Robert A. Buchanan
  • Patent number: 5659087
    Abstract: The present invention is directed to new diarylvinyl sulfoxides.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 19, 1997
    Assignee: Eli Lilly and Company
    Inventors: James A. Aikins, Tony Y. Zhang
  • Patent number: 5637684
    Abstract: Compounds are provided having the structure: ##STR1## wherein the L groups are spanner or linker units, the Y and T group are functional groups for interacting with target molecules of interest, the X groups are oxygen or sulfur and the E groups are H, conjugate groups or intermediate groups used during the synthesis of the compounds are prepared using H phosphonate type chemistry wherein the functional groups are added during an oxidization step.
    Type: Grant
    Filed: February 23, 1994
    Date of Patent: June 10, 1997
    Assignee: ISIS Pharmaceuticals, Inc.
    Inventors: Phillip D. Cook, Oscar Acevedo, Normand Hebert
  • Patent number: 5633409
    Abstract: Trifluoromethanesulfonic and p-toluenesulfonic acid bis- or tris(p-tert-butoxyphenyl)sulfonium salts are novel. They are prepared from bis(p-tert-butoxyphenyl)sulfoxide which is also novel. A chemically amplified positive resist composition which contains the sulfonium salt as a photo-acid generator is highly sensitive to deep-UV rays, electron beams and X-rays, can be developed with alkaline aqueous solution to form a pattern, and is thus suitable for use in a fine patterning technique.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: May 27, 1997
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Satoshi Watanabe, Youichi Ohsawa, Toshinobu Ishihara, Kazumasa Maruyama, Yoshihumi Takeda, Junji Shimada, Fujio Yagihashi, Katsuya Takemura
  • Patent number: 5446134
    Abstract: Bis(perfluorosulphonyl)methanes, process for preparing same and uses thereof. The compounds of the invention are based on the formula (1/nM)+[(R.sub.F SO.sub.2).sub.2 CY].sup.- in which Y denotes an electron-attracting group chosen from --C.dbd.N and RZ groupings in which Z denotes a carbonyl grouping, sulphonyl grouping or a phosphonyl grouping and R denotes an organic monovalent grouping, M denotes a metal having valency n or an organic group capable of existing in the cationic form, R.sub.F denotes a perfluoroalkyl or perfluoroaryl grouping. Said compounds are especially useful in the production of electrochemical devices.
    Type: Grant
    Filed: July 8, 1993
    Date of Patent: August 29, 1995
    Assignees: Centre National de la Recherche Scientifique, Hydro Quebec
    Inventors: Michel Armand, Djamila Benrabah, Jean-Yves Sanchez
  • Patent number: 5399773
    Abstract: Nitrophenyl alkyl ethers can be advantageously prepared by reacting a nitrophenol with an alkyl halide in water as the reaction medium in such a manner that the nitrophenol is laid before with the water and the alkyl halide and a hydrogen halide-binding compound are then added simultaneously.
    Type: Grant
    Filed: June 5, 1992
    Date of Patent: March 21, 1995
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernhard Beitzke, Robert Weitz
  • Patent number: 5393776
    Abstract: This invention relates to structurally novel acyclic tocotrienol analogs, which are useful for cholesterol/lipid lowering in cases of hypercholesterolemia and hyperlipidemia, and for atherosclerosis. Also provided are pharmaceutical compositions and a method of use employing those compositions.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: February 28, 1995
    Assignee: Bristol-Myers Squibb Company
    Inventor: Bradley C. Pearce
  • Patent number: 5300633
    Abstract: Azo compounds of the formula D.sup.o --N.dbd.N--K.sup.o, in which D.sup.o is a radical of the formula (2), (2a) or (2b) ##STR1## in which Y is a substituent which can be eliminated by alkali to form the vinyl group, X is chlorine or bromine and R is hydrogen, lower alkyl, phenyl or halogen, and K.sup.o is the radical of a coupling component or another radical which contains azo groups, K.sup.o containing a group of the formula --N(R.sup.o)--Z, in which R.sup.o is hydrogen or lower alkyl and Z is a radical of the formula ##STR2## in which A is halogen or cyanoamido, R.sup.20 is hydrogen or lower alkyl, and R.sup.21 has one of the meanings given for R.sup.20, or is an optionally methyl-substituted cycloalkylene radical, or is a phenyl radical, or in which R.sup.20 and R.sup.21, together with the nitrogen atom and if appropriate one or two further hetero groups, can form a 5- or 6-membered heterocyclic radical.
    Type: Grant
    Filed: May 8, 1992
    Date of Patent: April 5, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jorg Dannheim, Werner H. Russ
  • Patent number: 5296635
    Abstract: A preparation process of a bis(3-nitrophenoxy) compound represented by the formula: ##STR1## wherein X is a direct bond, divalent hydrocarbon having from 1 to 10 carbon atoms or a divalent group selected from --C(CF.sub.3).sub.2, --CO--, --S--, --SO--, SO.sub.2 --or --O--, which comprises reacting 4,4'-bisphenol with m-dinitrobenzene in the presence of an alkali metal carbonate or alkali metal hydrogen carbonate having a particle size of 250 .mu.m or less while removing generated water from the reaction system during the reaction. In one embodiment of the process, the reaction is carried out while simultaneously adding 4,4'-bisphenol and m-dinitrobenzene to a reaction vessel which was previously charged with the base and an aprotic polar solvent.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: March 22, 1994
    Assignee: Mitsui Toatsu Chemicals, Inc.
    Inventors: Motohiro Kase, Hitoshi Nakayama, Masaru Wada, Teruyuki Nagata, Akihiro Yamaguchi
  • Patent number: 5288742
    Abstract: The invention concerns .alpha.,.alpha.-dialkylbenzyl derivatives of the formula I ##STR1## wherein Ar.sup.1 is phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one or two nitrogen heteroatoms and optionally containing a further heteroatom selected from nitrogen, oxygen and sulphur;A.sup.1 is a direct link to X.sup.1 or is (1-3C)alkylene;X.sup.1 is oxy, thio, sulphinyl or sulphonyl;the phenylene group may optionally bear one or two substituents R.sup.3 ;each of R.sup.1 and R.sup.2, which may be the same or different, is (1-4C)alkyl, (2-4C)alkenyl, (2-4C)alkynyl, fluoro-(1-4C)alkyl, phenyl or phenyl-(1-4C)alkyl, provided that both of R.sup.1 and R.sup.2 are not methyl or fluoromethyl; andQ is cyano, amino, nitro, formyl, (1-4C)alkoxy, thiazolyl or (2-4C)alkanoyl;or a pharmaceutically-acceptable salt thereof;processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
    Type: Grant
    Filed: March 18, 1992
    Date of Patent: February 22, 1994
    Assignees: Imperial Chemical Industries PLC, ICI Pharma
    Inventors: Philip N. Edwards, David Waterson
  • Patent number: 5214069
    Abstract: The invention concerns a compound of the formula I, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl;A.sup.1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo(3-6C)alkylene;Ar.sup.2 is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; wherein R.sup.2 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or substituted (1-4C)alkyl; and whereinR.sup.3 is hydroxy-(1-4C)alkyl, mercapto-(1-4C)alkyl, (1-4C)alkoxy-(1-4C)alkyl, (3-4C)alkenyloxy-(1-4C)alkyl, (3-4C)alkynyloxy-(1-4C)alkyl, (1-4C)alkoxy-(2-4C)alkoxy-(1-4C)alkyl, (1-4C)alkylthio-(1-4C)alkyl, (1-4C)alkylsulphinyl-(1-4C)alkyl, (1-4C)alkylsulphonyl-(1-4C)alkyl, (1-4C)alkoxycarbonyl-(1-4C)alkyl, (2-4C)alkanoyl-(1-4C)alkyl, (2-4C)alkanoyloxy-(1-4C)alkyl or cyano-(1-4C)alkyl; or R.sup.
    Type: Grant
    Filed: January 23, 1992
    Date of Patent: May 25, 1993
    Assignees: Imperial Chemical Industries PLC, ICI Pharma
    Inventor: Jean-Marc M. M. Girodeau
  • Patent number: 5214070
    Abstract: The invention concerns a diaryl ether cycloalkane of the formula I, or a pharmaceutically-acceptable salt thereof, ##STR1## wherein Ar.sup.1 is optionally substituted phenyl or naphthyl; X.sup.1 is oxy, thio, sulphinyl or sulphonyl;Ar.sup.2 is optionally substituted phenylene, or a 6-membered heterocyclene moiety containing up to three nitrogen atoms;R.sup.1 is (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; andR.sup.2 and R.sup.3 together form a (3-6C)alkylene group which defines an optionally substituted ring having 4 to 7 ring atoms.The invention also concerns processes for the manufacture of a diaryl ether cycloalkane of the formula I, or a pharmaceutically-acceptable salt thereof, and pharmaceutical compositions containing said cycloalkane. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.
    Type: Grant
    Filed: August 21, 1991
    Date of Patent: May 25, 1993
    Assignees: Imperial Chemical Industries PLC, ICI Pharma
    Inventors: Thomas G. C. Bird, Philip N. Edwards
  • Patent number: 5167846
    Abstract: Sulfoxides of bisthiomethylated and tristhiomethylated phenols of formulae I and II ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.18 alkyl, cyclohexyl or C.sub.7 -C.sub.9 phenylalkyl,R.sub.2 and R.sub.3 are each independently of the other hydrogen or methyl,R.sub.4 is C.sub.4 -C.sub.18 alkyl, phenyl, C.sub.7 -C.sub.9 phenylalkyl, C.sub.1 -C.sub.4 alkyl-substituted phenyl,hydroxyethyl or a radical --(CH.sub.2).sub.r COOR.sub.5, wherein r is 1 or 2 and R.sub.5 is C.sub.1 -C.sub.18 alkyl,Z is sulfur ##STR2## wherein R.sub.2 and R.sub.3 are as defined above, or are a direct bond, and n, m and p are each independently of one another 0 or 1, and mixtures thereof with the corresponding non-oxidized compounds, are suitable stabilizers for materials which are sensitive to oxidative, thermal and/or light-induced degradation.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: December 1, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans-Rudolf Meier, Rita Pitteloud
  • Patent number: 5152922
    Abstract: Novel 1,4-distyrylbenzene compounds of the formula ##STR1## and mixtures thereof with compounds of the formulae ##STR2## and/or ##STR3## in which R.sub.1 is C.sub.1 -C.sub.4 -alkyl or phenyl, R.sub.2 is cyano, COOC.sub.1 -C.sub.4 -alkyl or chlorine and R.sub.3 is hydrogen or chlorine, agents for the fluorescent brightening of polyester fibers and a process for the preparation of the compounds of the formula 1 or mixtures thereof with compounds of the formulae 2 and/or 3 and also novel aldehydes which can be isolated as intermediates.
    Type: Grant
    Filed: March 15, 1991
    Date of Patent: October 6, 1992
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans R. Meyer, Leonardo Guglielmetti
  • Patent number: 5152826
    Abstract: An herbicide compound of the formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n -- wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl;R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms;R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.3 and R.sup.4 together are oxo;R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl;R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; orR.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms;R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n --wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.
    Type: Grant
    Filed: October 16, 1991
    Date of Patent: October 6, 1992
    Assignee: Imperial Chemical Industries PLC
    Inventor: Christopher G. Knudsen
  • Patent number: 5116869
    Abstract: 2-Substituted-2-cyclopentenones represented by the formula (I): ##STR1## wherein A is a hydroxyl group or ##STR2## and B is a hydrogen atom or A and B are bonded together to form one bonding arm;R.sup.1 represents a substituted or unsubstituted hydrocarbon group having 1 to 10 carbon atoms;R.sup.2 represents a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms;R.sup.3 represents a substituted or unsubstituted aliphatic hydrocarbon group having 1 to 10 carbon atoms; wherein,when R.sup.3 is a single bond bonded to the cyclopentene skeleton, X represents a hydrogen atom, a hydroxyl group or a protected hydroxyl group; andwhen R.sup.3 is a double bond bonded to the pentene skeleton, X represents a bonding arm constituting a part of said double bond; andm and n independently represent 0, 1 or 2.
    Type: Grant
    Filed: September 3, 1991
    Date of Patent: May 26, 1992
    Assignee: Teijin Limited
    Inventors: Satoshi Sugiura, Atsuo Hazato, Toru Minoshima, Yoshinori Kato, Yasuko Koshihara, Seizi Kurozumi