Plural Alicyclic Rings Containing Patents (Class 568/367)
  • Patent number: 9012391
    Abstract: Described are spiroalkyl- and -alkenylketones and esters thereof, a method for their production and fragrance compositions comprising them.
    Type: Grant
    Filed: June 9, 2008
    Date of Patent: April 21, 2015
    Assignee: Givaudan SA
    Inventors: Thierry Granier, Nicolas Anorga, Markus Gautschi, Bernadette Bourdin Trunz
  • Patent number: 9000224
    Abstract: The present invention relates to a process for the preparation of pillar[5]quinone and further relates to an easy-to-operate and chromatography-free process for the preparation of crystalline pillar[5]quinone by the oxone/iodobenzene-mediated oxidative de-aromatization of readily available 1,4-dimethoxypillar[5]arenes in good yields.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: April 7, 2015
    Assignee: Council of Scientific & Industrial Research
    Inventors: Jessy Sanjayan Gangadhar, Ishwara Shivakumar Kilingaru
  • Publication number: 20140378360
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: September 12, 2014
    Publication date: December 25, 2014
    Inventors: Hugo Robert Germain DENUTTE, Johan SMETS, An PINTENS, Koen VAN AKEN, Freek Annie Camiel VRIELYNCK
  • Patent number: 8858829
    Abstract: The present invention intends to provide a novel cyclohexane compound that can form a liquid crystal composition of which response speed is improved when mixed with a nematic liquid crystal and the like and to provide a specified liquid crystal composition in which a novel cyclohexane compound is mixed. The novel cyclohexane compound is represented by the following formula (1). (In the formula (1), R1 and R2 represent the same or different R, ROCO or RCOO, and the R represents an alkyl group. The alkyl group may have an unsaturated bond, and, in the group, —CH2— may be substituted with —O—, —CO— or —COO—, and a part of or an entirety of hydrogen atoms may be substituted with a halogen atom or a cyano group. X and Y each independently represents a halogen atom or a hydrogen atom and does not simultaneously represent a hydrogen atom. Further, alternatively, X represents an oxygen atom and Y represents a direct bond to the oxygen atom.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: October 14, 2014
    Assignees: Organo Science Co., Ltd., Chiracol Co., Ltd.
    Inventors: Kazuo Okamoto, Toshihiro Shibata
  • Patent number: 8846747
    Abstract: Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: September 30, 2014
    Assignees: University of Rochester, Southern Research Institute
    Inventors: David S. Goldfarb, Joseph A. Maddry, Lynn Rasmussen, Ellie Lucille White, Krister Wennerberg
  • Publication number: 20140221694
    Abstract: The invention describes previously undisclosed crystal forms of astaxanthin designated crystal form I and II. It has been surprisingly found that the two crystal forms of astaxanthin show an improved bioavailability, a relatively high solubility in specific organic solvents and an increased long-term stability. For example the new forms are stable in solid form for at least 90 days at a temperature of 20° C.-40° C. It was further found that the two crystal forms can be prepared from each other. Therefore the invention also relates to methods for preparing said crystal forms. In addition, the invention relates to administration forms (hereinafter also called “formulations”) comprising one of the two crystal forms according to the invention or mixtures thereof dissolved or suspended in oil or organic-solvent.
    Type: Application
    Filed: April 4, 2014
    Publication date: August 7, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Jingfei GUO, Matthew J. JONES, Christian SCHAEFER, Joachim ULRICH, Viviane VERLHAC-TRICHET
  • Publication number: 20140070145
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: November 14, 2013
    Publication date: March 13, 2014
    Applicant: NOVALED AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Patent number: 8642815
    Abstract: The present invention is directed to novel methods for production of 5-epi-?-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-?-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one from premnaspirodiene as starting material.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: February 4, 2014
    Assignee: Allylix, Inc.
    Inventors: Bryan N. Julien, David M. Wallace
  • Publication number: 20140024635
    Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: The Trustees of The University Of Pennsylvania
    Inventors: WILLIAM F. DeGRADO, JUN WANG
  • Patent number: 8624057
    Abstract: There is provided an isoprenoid according to the general formula (I) wherein R1 and R2 are independently selected from H and alkyl; and R3, R4, R5 and R6 are independently selected from groups of the general formula (II) and (III) wherein R7 and R8 each represent a group of general formula CO—R9, in which each R9 is independently selected from H, OH, alkyl and alkoxy groups, or R7 and/or R8 present in R3 and R4 and/or in R5 and R6 combine to form a group of the general formula (IV) wherein R10 is selected from OH and alkoxy; or salts thereof. The isoprenoids are of particular use in the preparation of liposomes, for use in the delivery of pharmaceutically active components to a subject human or animal.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 7, 2014
    Assignee: University of Plymouth
    Inventor: Steven John Rowland
  • Publication number: 20130317116
    Abstract: This invention provides an external skin preparation with high safety aimed at wrinkle improvement and wrinkle prevention. Specifically, the invention relates to an external skin preparation comprising, as an active ingredient, a carotenoid.
    Type: Application
    Filed: February 2, 2012
    Publication date: November 28, 2013
    Applicant: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Takashi Maoka, Takashi Ishibashi
  • Patent number: 8524952
    Abstract: A modified dimethylnaphthalene formaldehyde resin obtained by modifying a polyfunctional dimethylnaphthalene formaldehyde resin having a constituent unit represented by the following general formula [1] in a molecule thereof with at least one member selected from the group consisting of a phenol represented by the following general formula [2], a naphthol represented by the following general formula [3] and a naphthol represented by the following general formula [4] provided that at least any of the naphthol represented by the general formula [3] or the naphthol represented by the general formula [4] must be included.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: September 3, 2013
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Seiji Kita, Masashi Ogiwara, Mitsuharu Kitamura, Dai Oguro, Gou Higashihara
  • Publication number: 20130137662
    Abstract: The present invention relates to the use canthaxanthin and/or 25-hydroxy vitamin D3 (25-OH D3) for improving reproductive performance of roosters. More particularly, the invention relates to the use of Canthaxanthin and/or 25-hydroxy canthaxanthin in the manufacture of a food or veterinary composition for improving reproductive performance of roosters.
    Type: Application
    Filed: December 7, 2010
    Publication date: May 30, 2013
    Inventor: Jose Maria Hernandez
  • Publication number: 20130122560
    Abstract: The present invention is directed to novel methods for production of 5-epi-?-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethylspiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. Provided are methods for production of premnaspirodiene from a terpene substrate, methods for production of 5-epi-?-vetivone from premnaspirodiene as starting material, and methods for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one from premnaspirodiene as starting material.
    Type: Application
    Filed: December 13, 2012
    Publication date: May 16, 2013
    Inventors: Bryan N. Julien, David M. Wallace
  • Publication number: 20130096175
    Abstract: Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-cyclohexanedione, 2-propanoyl-5-[4-fluorophenyl]-; 1,3-cyclohexanedione, 2-acetyl-5-[thien-2-yl]-; 1,3-cyclohexanedione, 2-acetyl-5-butyl-; and 1,3-cyclohexanedione, 2-propanoyl-5-[bicyclo[2.2.1]hept-2-en-5-yl]-. The compounds can be used to alter the lifespan of eukaryotic organisms and treat inflammation.
    Type: Application
    Filed: November 17, 2010
    Publication date: April 18, 2013
    Applicants: SOUTHERN RESEARCH INSTITUTE, UNIVERSITY OF ROCHESTER
    Inventors: David S. Goldfarb, Joseph A. Maddry, Lynn Rasmussen, Ellie Lucile White, Krister Wennerberg
  • Publication number: 20130092875
    Abstract: The present invention intends to provide a novel cyclohexane compound that can form a liquid crystal composition of which response speed is improved when mixed with a nematic liquid crystal and the like and to provide a specified liquid crystal composition in which a novel cyclohexane compound is mixed. The novel cyclohexane compound is represented by the following formula (1). (In the formula (1), R1 and R2 represent the same or different R, ROCO or RCOO, and the R represents an alkyl group. The alkyl group may have an unsaturated bond, and, in the group, —CH2— may be substituted with —O—, —CO— or —COO—, and a part of or an entirety of hydrogen atoms may be substituted with a halogen atom or a cyano group. X and Y each independently represents a halogen atom or a hydrogen atom and does not simultaneously represent a hydrogen atom. Further, alternatively, X represents an oxygen atom and Y represents a direct bond to the oxygen atom.
    Type: Application
    Filed: June 30, 2011
    Publication date: April 18, 2013
    Applicants: Chiracol Co., Ltd., Organo Science Co., Ltd.
    Inventors: Kazuo Okamoto, Toshihiro Shibata
  • Publication number: 20120329696
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: May 24, 2012
    Publication date: December 27, 2012
    Inventors: Hugo Robert Germain Denutte, Johan Smets, An Pintens, Jeanne Alfons Van Aken, Freek Annie Camiel Vrielynck
  • Publication number: 20120264820
    Abstract: A compound, pharmaceutical composition and method for the treatment of mammals wherein the active therapeutic agent is a compound having the structure: wherein: R1 is an electronegative substituent, R2 is R1 or alkyl, R3 is H or O-alkyl, R4 and R5 are the same or different and are alkyl and R6 is H or OH.
    Type: Application
    Filed: December 31, 2007
    Publication date: October 18, 2012
    Inventors: Kinfe Redda, Chavonda Janeebra Mills, Nelly Maleeva
  • Patent number: 8277903
    Abstract: The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to are methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: October 2, 2012
    Assignee: Academia Sinica
    Inventors: Tahsin J. Chow, Chung-Chih Wu, Ta-Hsien Chuang, Hsing-Hung Hsieh, Hsin-Hui Huang
  • Patent number: 8247615
    Abstract: The present invention is concerned with a process to convert xanthophyll esters derived from Capsicum sources to their free (non-esterified) forms. The present invention is concerned with a process for obtaining Capsicum derived xanthophylls that meet the finished product needs for purity, yield, ease of use, industrial compatibility and cost that are required to make product suitable for the nutritional supplement, food and beverage industries. The present invention is concerned with a process which yields from 60 to 80%, of xanthophyll materials and nearly quantitative recovery of all input xanthophylls, which xanthophylls are of high purity. The present invention concerns a method to obtain xanthophyll esters present almost exclusively in the trans form when isolated from the natural plant sources. The present invention concerns a process to re-convert cis product back to the more desired trans form.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: August 21, 2012
    Assignee: Kalamazoo Holdings, Inc.
    Inventors: Mark Reilly, Josh James Tuinstra, Lucas Chadwick, Mark Porter, James Barren, Gregory S. Reynhout
  • Publication number: 20120149886
    Abstract: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
    Type: Application
    Filed: April 10, 2009
    Publication date: June 14, 2012
    Applicant: MICROBIA, INC.
    Inventors: Richard B. Bailey, Kevin T. Madden, Joshua Trueheart, Reed Doten, Maria Mayorga, Joshua Griffin Dunn, Dan Dueppen
  • Patent number: 8124811
    Abstract: The present invention is directed to novel methods for production of 5-epi-?-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one, which are useful for their fragrant qualities. In one embodiment the present invention describes a method for production of 5-epi-?-vetivone by the use of premnaspirodiene as starting material. In another embodiment the present invention describes a method for production of 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one by the use of premnaspirodiene as starting material. In yet another embodiment the present invention describes a novel method for production of premnaspirodiene from a terpene substrate. Use of the fragrant components or any composition containing the component can be advantageously employed in the perfumery industry.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: February 28, 2012
    Assignee: Allylix, Inc.
    Inventors: Bryan N. Julien, David M. Wallace
  • Publication number: 20120029088
    Abstract: This invention provides a highly safe anti-anxiety composition that can be used for treatment or prevention of anxiety disorders. Such anti-anxiety composition comprises, as an active ingredient, a carotenoid.
    Type: Application
    Filed: July 21, 2011
    Publication date: February 2, 2012
    Applicant: JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Hideaki HARA, Atsushi OOYAGI, Takashi ISHIBASHI
  • Patent number: 8097761
    Abstract: A method for producing a composition containing carotenoid at a content of 80% or greater, characterized in performing extraction on a culture of a microorganism, a concentrate of the culture, or a dried substance thereof with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, lower dialkylketones and ethers; and then washing a precipitate, obtained by concentrating the extract solution, with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, hydrocarbon-based solvents and lower dialkylketones; and food, a pharmaceutical composition or a cosmetic substance comprising the carotenoid-containing composition.
    Type: Grant
    Filed: March 28, 2007
    Date of Patent: January 17, 2012
    Assignee: JX Nippon Oil & Energy Corporation
    Inventors: Tomoyuki Ishizaki, Satoru Ishikawa, Akira Tsubokura, Kazuaki Hirasawa
  • Publication number: 20110308556
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: June 22, 2011
    Publication date: December 22, 2011
    Inventors: Johan Smets, Hugo Robert Germain Denutte, An Pintens, Koen Van Aken, Freek Annie Camiel Vrielynck
  • Publication number: 20110309309
    Abstract: The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them.
    Type: Application
    Filed: July 8, 2011
    Publication date: December 22, 2011
    Applicant: NOVALED AG
    Inventors: Horst Hartmann, Olaf Zeika, Andrea Lux, Steffen Willmann
  • Publication number: 20110282083
    Abstract: The present invention is concerned with a process to convert xanthophyll esters derived from Capsicum sources to their free (non-esterified) forms. The present invention is concerned with a process for obtaining Capsicum derived xanthophylls that meet the finished product needs for purity, yield, ease of use, industrial compatibility and cost that are required to make product suitable for the nutritional supplement, food and beverage industries. The present invention is concerned with a process which yields from 60 to 80%, of xanthophyll materials and nearly quantitative recovery of all input xanthophylls, which xanthophylls are of high purity. The present invention concerns a method to obtain xanthophyll esters present almost exclusively in the trans form when isolated from the natural plant sources. The present invention concerns a process to re-convert cis product back to the more desired trans form.
    Type: Application
    Filed: May 14, 2010
    Publication date: November 17, 2011
    Applicant: KALAMAZOO HOLDINGS, INC.
    Inventors: Mark Reilly, Josh James Tuinstra, Lucas Chadwick, Mark Porter, James Barren, Gregory S. Reynhout
  • Publication number: 20110258732
    Abstract: The present invention relates to tomato plants that are resistant to pathogenic plants of the Orobanchaceae family, to methods for producing said plants and to the use thereof. The invention further relates to a method of controlling parasitic plants of the Orobanchaceae family, particularly O. aegyptiaca, in tomato crops and for securing tomato fruit production.
    Type: Application
    Filed: November 18, 2009
    Publication date: October 20, 2011
    Inventors: Joseph Hershenhorn, Evgenia Dor, Yoram Kapulnik, Samdar Goldar Weininger, Bruria Ben Dor
  • Publication number: 20110180010
    Abstract: The invention describes previously undisclosed crystal forms of astaxanthin designated crystal form I and II. It has been surprisingly found that the two crystal forms of astaxanthin show an improved bioavailability, a relatively high solubility in specific organic solvents and an increased long-term stability. For example the new forms are stable in solid form for at least 90 days at a temperature of 20° C.-40° C. It was further found that the two crystal forms can be prepared from each other. Therefore the invention also relates to methods for preparing said crystal forms. In addition, the invention relates to administration forms (hereinafter also called “formulations”) comprising one of the two crystal forms according to the invention or mixtures thereof dissolved or suspended in oil or organic-solvent.
    Type: Application
    Filed: June 2, 2009
    Publication date: July 28, 2011
    Inventors: Jingfei Guo, Matthew J. Jones, Christian Schaefer, Joachim Ulrich, Viviane Verlhactrichet
  • Patent number: 7977387
    Abstract: The invention provides novel compounds according to formula I relates to compounds with the general formula I said compounds being useful, e.g. in the treatment of inflammatory, ophthalmic diseases or cancer.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: July 12, 2011
    Assignee: Leo Pharma A/S
    Inventors: Erik Rytter Ottosen, Anne Marie Horneman, Xifu Liang, Søren Christian Schou, Sophie Elisabeth Havez, Thomas Peter Sabroe
  • Publication number: 20110092584
    Abstract: The present invention relates to cannabinoic quinone compounds, and especially to their medical use. In particular five cannabinoic quinones, designated HU-331, HU-336, HU-345, HU-395 and HU-396 are herein described as active agents in pharmaceutical compositions. Said compounds and compositions thereof are intended for the treatment of inflammatory, infectious, auto-immune and particularly hyperproliferative disorders. Thus, the compounds of the invention may be used as anti-tumor agents, or for the treatment of cancer. Furthermore, three of these compounds, HU-345, HU-395 and HU-396, are novel cannabinoic quinones and thus are also claimed herein.
    Type: Application
    Filed: January 14, 2005
    Publication date: April 21, 2011
    Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Raphael Mechoulam, Natalya M. Kogan, Ruth Rabinowitz, Michael Schlesinger
  • Publication number: 20110021843
    Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
    Type: Application
    Filed: October 13, 2010
    Publication date: January 27, 2011
    Applicant: MICROBIA, INC.
    Inventors: Richard Bailey, Kevin T. Madden, Joshua Trueheart
  • Publication number: 20110020316
    Abstract: Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.
    Type: Application
    Filed: July 21, 2010
    Publication date: January 27, 2011
    Applicant: U.S. Nutraceuticals, LLC d/b/a Valensa International
    Inventors: John A. Minatelli, W. Stephen Hill, Swati Sebastian Thomas, Lingan Rajendran, Rudi E. Moerck
  • Publication number: 20100292128
    Abstract: Described are spiroalkyl- and -alkenylketones and esters thereof, a method for their production and fragrance compositions comprising them.
    Type: Application
    Filed: June 9, 2008
    Publication date: November 18, 2010
    Applicant: Givaudan SA
    Inventors: Thierry Granier, Nicolas Anorga, Markus Gautschi, Bernadette Bourdin Trunz
  • Publication number: 20100183537
    Abstract: Compositions that provide health benefits and methods regarding same are presented. In an embodiment, the present invention provides a primary composition comprising at least one carotenoid-containing material, enriched in Z isomers of the carotenoid compound. For example, the carotenoid-containing material contains by weight a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof than of 13-Z isomer.
    Type: Application
    Filed: August 7, 2007
    Publication date: July 22, 2010
    Applicant: NESTEC S.A.
    Inventors: Karlheinz Bortlik, Pierre Lambelet, Myriam Richelle
  • Publication number: 20100174118
    Abstract: A method for producing a composition containing carotenoid at a content of 80% or greater, characterized in performing extraction on a culture of a microorganism, a concentrate of the culture, or a dried substance thereof with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, lower dialkylketones and ethers; and then washing a precipitate, obtained by concentrating the extract solution, with at least one selected from the group consisting of lower alcohols, water-containing lower alcohols, hydrocarbon-based solvents and lower dialkylketones; and food, a pharmaceutical composition or a cosmetic substance comprising the carotenoid-containing composition.
    Type: Application
    Filed: March 28, 2007
    Publication date: July 8, 2010
    Applicants: Asahi Kasei Pharma Corporation, Nippon Oil Corporation
    Inventors: Tomoyuki Ishizaki, Satoru Ishikawa, Akira Tsubokura, Kazuaki Hirazawa
  • Publication number: 20100152238
    Abstract: Novel cannabinoid-derived quinone derivatives (quinonoid derivatives) having a substituted hydroxyl group, pharmaceutical compositions comprising same and uses thereof as anti-proliferative agents, are provided.
    Type: Application
    Filed: March 5, 2008
    Publication date: June 17, 2010
    Applicant: Yissum Research Development Company of The Hebrew University of Jerusalem
    Inventors: Raphael Mechoulam, Natalya Kogan
  • Patent number: 7572939
    Abstract: A novel soluble pentacene (C22H14) precursor 6,13-dihydro-6,13-methanopentacene-15-one, a method for its production and intermediates therefor as well as pentacene films and coated surfaces. Thermolysis of the precursor at 150° C. to 350° C. induces an expulsion of carbon monoxide to generate pentacene in high yield. The high solubility of the precursor compound, as well as its production of non-contaminated pentacene, makes it an excellent material in the application of organic thin film transistors on surfaces.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: August 11, 2009
    Assignee: Academia Sinica
    Inventors: Tahsin J. Chow, Kew-Yu Chen, Jiunn-Jye Hwang
  • Patent number: 7547697
    Abstract: Compounds of formula (I): as well as pharmaceutically acceptable salts and esters thereof for use as pharmaceutical compositions.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: June 16, 2009
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Kurt Amrein, Daniel Hunziker, Bernd Kuhn, Werner Neidhart, Alexander V. Mayweg
  • Publication number: 20090069442
    Abstract: The present invention provides therapeutic agents for sensory disorders represented by the following formula (1): [wherein R1, R2, and R3 each represent a hydrogen atom or a methyl group, and X represents a linear or branched C10-C28 alkylene or alkenylene group]. The cyclohexenone long chain alcohol of the present invention improves hyperalgesia or hypoalgesia, and thus is useful as therapeutic agents for sensory disorders. Sensory disorders that can be prevented or treated by the present invention include chronic intractable pain, neurogenic pain, reduction of pain threshold caused by nerve injuries, hypesthesia or hyperesthesia caused by diabetes and nerve injuries, and the like.
    Type: Application
    Filed: January 18, 2006
    Publication date: March 12, 2009
    Inventors: Hirohito Shiomi, Yutaka Tamura, Bang Luu, Masashi Yamada, Keizou Koyama, Hiroto Suzuki
  • Publication number: 20080293975
    Abstract: The present invention provides a method for collecting xanthophylls, the method comprising an adsorption step of contacting a sample containing xanthophylls with a hydrophilic resin to allow the resin to adsorb the xanthophylls; and a desorption step of eluting the xanthophylls adsorbed to the resin with a polar solvent. Preferably, the method comprises a step of washing the resin between the adsorption step and the desorption step. As the resin, a hydrophilic, acrylic and/or methacrylic resin is preferably used.
    Type: Application
    Filed: February 21, 2006
    Publication date: November 27, 2008
    Applicant: YAMAHA HATSUDOKI KABUSHIKI KAISHA
    Inventors: Nagisa Murakami, Yumika Okada, Masaharu Ishikura
  • Publication number: 20080234521
    Abstract: Mixtures of specific crystal forms of astaxanthin and the individual crystal forms designated crystal Form I and II and disclosed together with methods for preparing said crystal Forms. Methods for preparing nutritional dosage forms including the disclosed astaxanthin crystal forms for the life science industry are also disclosed.
    Type: Application
    Filed: February 15, 2008
    Publication date: September 25, 2008
    Applicant: PHARES PHARMACEUTICAL RESEARCH N. V.
    Inventors: Steve LEIGH, Mathew Louis Steven Leigh, Peter Van Hoogevest
  • Publication number: 20080200478
    Abstract: This invention comprises antineoplastic curcumin derivatives and methods of preparation and use thereof. Particular reference is made to the following isomeric compounds wherein R1, R2, and R3 are selected from the group consisting of H, OH, OCH3, and COOH.
    Type: Application
    Filed: October 29, 2007
    Publication date: August 21, 2008
    Inventor: Byron C. Robinson
  • Patent number: 7138520
    Abstract: In part, the present invention is directed to coordination complexes comprising a therapeutic agent. In one aspect, the subject compositions comprise a platinum metal center and a covalently attached therapeutic agent.
    Type: Grant
    Filed: January 12, 2004
    Date of Patent: November 21, 2006
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Carmen M. Barnes, Ariel Haskel, Katie R. Barnes
  • Patent number: 6939479
    Abstract: Described herein are compounds of formula I wherein M1, M2 and M3 have the meanings recited in the disclosure, liquid crystalline mixtures and polymers containing them, and the use of the compounds of formula I, the liquid crystalline mixtures and the polymers containing them in optical and electrooptical devices like liquid crystal displays or projection systems, patterned films and optical elements like polarizers, retardation films, compensators, color filters, holographic elements or polarization beam splitters, for photoswitching, in anisotropic membranes for the permeation of gases or fluids, adhesives, synthetic resins with anisotropic mechanical properties, cosmetic or pharmaceutical compositions, UV absorbers and sunscreens, diagnostics or liquid crystal pigments, for decorative and security applications, in nonlinear optics, optical information storage or as dopants.
    Type: Grant
    Filed: April 5, 2002
    Date of Patent: September 6, 2005
    Assignee: Merck Patent GmbH
    Inventors: Louise Diane Farrand, Christopher Worrall, Owain Llyr Parri, Ian Victor Edward Hassall, Julian Frederick Samuel Vaughan-Spickers
  • Patent number: 6909021
    Abstract: The present invention provides a method for extracting carotenoids from green plant materials using supercritical fluid extraction. A first and second supercritical fluid extraction is performed on the green plant composition at two different pressures to obtain two extracts. The first extract includes substantial amounts of ?-carotene. The second extract may have a controlled concentration of ?-carotene, and includes substantial amounts of lutein.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: June 21, 2005
    Assignee: Alfalfa America, Inc.
    Inventor: Lance B. Crombie
  • Patent number: 6737552
    Abstract: The present invention provides a method for extracting carotenoids from green plant materials using supercritical fluid extraction. A first and second supercritical fluid extraction is performed on the green plant composition at two different pressures to obtain two extracts. The first extract includes substantial amounts of &bgr;-carotene. The second extract is substantially free of &bgr;-carotene, and includes substantial amounts of lutein.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: May 18, 2004
    Inventor: Lance B. Crombie
  • Patent number: 6639113
    Abstract: A process is described for preparing dry powders of one or more oxygenated carotenoids by a) dispersing one or more oxygenated carotenoids in an aqueous molecular dispersion or colloidal dispersion of a protecting colloid and b) converting the dispersion formed into a dry powder by removing the water and any solvents additionally used and drying, in the presence or absence of a coating material, which comprises using as protecting colloid in process step a) at least one partially hydrolyzed soybean protein having a degree of hydrolysis greater than 5%.
    Type: Grant
    Filed: December 17, 2001
    Date of Patent: October 28, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Frank Runge, Erik Lüddecke, Helmut Auweter, Angelika-Maria Pfeiffer, Willy Hinz
  • Publication number: 20030186939
    Abstract: A &ohgr;-cycloalkyl-prostaglandin E2 derivatives of the formula (I) 1
    Type: Application
    Filed: September 11, 2002
    Publication date: October 2, 2003
    Inventors: Kousuke Tani, Shuichi Ohuchida
  • Patent number: 6562782
    Abstract: The present invention related to an oligocycloalkanoid compound comprising formula (I) wherein m, n, and o are independently an integer from 0 to 2; A1 through A10 are independently a direct link, alkylene, alkylene-O—, carbonyl, oxygen, or sulfur; X and Y are independently hydrogen, hydroxy, alkyl, or in combination an electrophilic group; and R1 through R10 are independently hydrogen, hydroxy, alkyl, alkenyl, alkynyl, substituted or unsubstituted aryl, N-, S-, or O-heterocycles, fused or multi-ring aryl with or without hetero ring members, arylalkyl, arylalkenyl, arylalkynyl, alkylphenyl, alkenylphenyl, alkynylphenyl, alkoxy, alkenyloxy, alkynyloxy, substituted or unsubstituted aryloxy, substituted or unsubstituted arylalkoxy, alkylacyl, alkenylacyl, alkynylacyl, arylacyl, aroyl, alkylaroyl, aminoaroyl, aminoalkylacyl, aminoalkyl, aminoalkenyl, aminoalkynyl, amino, alkylamino, alkenylamino, alkynylamino, arylamino, dialkylamino, dialkenylamino, dialkynylamino, arylalkylamino, arylalk
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: May 13, 2003
    Assignee: University of Rochester
    Inventors: Benjamin L. Miller, Robert D. Hubbard